{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:49:00Z","timestamp":1791514140717,"version":"4.3.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"DOI":"10.1007\/s00210-026-05955-w","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:50:53Z","timestamp":1791510653000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Berberine inhibits gastric cancer progression by targeting canonical Wnt\/\u03b2-catenin signaling in AGS cells"],"prefix":"10.1007","author":[{"given":"Li","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"5955_CR1","doi-asserted-by":"crossref","unstructured":"Apurva, Chaudhary P, Bahuguna S (2026) Unravelling the diabetes-cancer nexus: an interlinking disease with risk factors, screening, management, treatments, and challenges. Curr Cancer Ther Rev","DOI":"10.2174\/0115733947414188251210123952"},{"key":"5955_CR2","doi-asserted-by":"publisher","DOI":"10.2174\/0113895575431891260131203159","author":"S Arfi","year":"2026","unstructured":"Arfi S, Srivastava N, Bakshi V, Sharma N (2026) Synergistic combinations of natural and synthetic agents: a novel therapeutic frontier in breast cancer management. Mini Rev Med Chem. https:\/\/doi.org\/10.2174\/0113895575431891260131203159","journal-title":"Mini Rev Med Chem"},{"key":"5955_CR3","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.70195","author":"H Baba","year":"2026","unstructured":"Baba H, Ishimoto T, Baba Y, Hayashi H, Iwatsuki M (2026) Advances in gastric cancer research: insights into carcinogenesis, the tumor microenvironment, metastasis, and factors influencing prognosis. Ann Gastroenterol Surg. https:\/\/doi.org\/10.1002\/ags3.70195","journal-title":"Ann Gastroenterol Surg"},{"key":"5955_CR4","doi-asserted-by":"crossref","unstructured":"Baghdasaryan I, Martirosyan D (2026) Berberis and Coptis species as sources of berberine in glucose-regulating teas and capsules: mechanisms, clinical evidence, and translational challenges. Bioact Mol Pharm 3(5):54\u201370","DOI":"10.31989\/bmp.v3i5.1974"},{"key":"5955_CR5","doi-asserted-by":"crossref","unstructured":"Bharathy Mariappan Ragupathi A, Dang CV, Zabransky DJ (2026) Wnt signaling and the tumor microenvironment: implications for cancer progression and therapeutics. Oncogene 1\u201311","DOI":"10.1038\/s41388-026-03731-x"},{"key":"5955_CR6","doi-asserted-by":"crossref","unstructured":"Choo J, Sargsyan A, Khachatryan V, Lonardi S, Pietrantonio F, Sundar R et al (2026) Advances in the management of metastatic gastric cancer: current strategies and emerging therapeutics. Nat Rev Clin Oncol 1\u201318","DOI":"10.1038\/s41571-026-01134-1"},{"key":"5955_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1604071","volume":"16","author":"K-Q Fan","year":"2025","unstructured":"Fan K-Q, Zhang L, Song F, Zhang Y-H, Chen T, Cheng X et al (2025) Pharmacological properties and therapeutic potential of berberine: a comprehensive review. Front Pharmacol 16:1604071","journal-title":"Front Pharmacol"},{"issue":"3","key":"5955_CR8","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3390\/biom13030483","volume":"13","author":"Y Gao","year":"2023","unstructured":"Gao Y, Chen N, Fu Z, Zhang Q (2023) Progress of Wnt signaling pathway in osteoporosis. Biomolecules 13(3):483","journal-title":"Biomolecules"},{"issue":"9","key":"5955_CR9","doi-asserted-by":"publisher","first-page":"4364","DOI":"10.3390\/ijms26094364","volume":"26","author":"S Ghafoor","year":"2025","unstructured":"Ghafoor S, Garcia E, Jay DJ, Persad S (2025) Molecular mechanisms regulating epithelial mesenchymal transition (EMT) to promote cancer progression. Int J Mol Sci 26(9):4364","journal-title":"Int J Mol Sci"},{"issue":"12","key":"5955_CR10","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.3390\/genes15121597","volume":"15","author":"S Iluta","year":"2024","unstructured":"Iluta S, Nistor M, Buruiana S, Dima D (2024) Wnt signaling pathway in tumor biology. Genes 15(12):1597","journal-title":"Genes"},{"key":"5955_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.762817","volume":"11","author":"SO Imodoye","year":"2021","unstructured":"Imodoye SO, Adedokun KA, Muhammed AO, Bello IO, Muhibi MA, Oduola T et al (2021) Understanding the complex milieu of epithelial-mesenchymal transition in cancer metastasis: new insight into the roles of transcription factors. Front Oncol 11:762817","journal-title":"Front Oncol"},{"key":"5955_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.624494","volume":"7","author":"M Javed Iqbal","year":"2021","unstructured":"Javed Iqbal M, Quispe C, Javed Z, Sadia H, Qadri QR, Raza S et al (2021) Nanotechnology-based strategies for berberine delivery system in cancer treatment: pulling strings to keep berberine in power. Front Mol Biosci 7:624494","journal-title":"Front Mol Biosci"},{"key":"5955_CR13","doi-asserted-by":"publisher","first-page":"1791005","DOI":"10.3389\/fphar.2026.1791005","volume":"17","author":"S Li","year":"2026","unstructured":"Li S, Jiao M, Ma C, Song Y, Chang L, Huo B (2026) Potential roles of plant metabolites and Traditional Chinese Medicine formulas in regulating glycolysis-OXPHOS plasticity in gastric precancerous lesions and gastric cancer: a critical appraisal of the evidence. Front Pharmacol 17:1791005","journal-title":"Front Pharmacol"},{"key":"5955_CR14","doi-asserted-by":"publisher","DOI":"10.2174\/0115680266431904251126065242","author":"G Lyu","year":"2026","unstructured":"Lyu G, Zhang Y, Li D (2026) Wnt signaling in tumorigenesis: from molecular mechanisms to precision therapeutic targets. Curr Top Med Chem. https:\/\/doi.org\/10.2174\/0115680266431904251126065242","journal-title":"Curr Top Med Chem"},{"key":"5955_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-026-04311-5","author":"M Moghbeli","year":"2026","unstructured":"Moghbeli M (2026) C-MYC as a key effector of WNT, PI3K\/AKT, MAPK, and TGF-\u03b2 signaling pathways in regulation of epithelial-mesenchymal transition during tumor metastasis. Cancer Cell Int. https:\/\/doi.org\/10.1186\/s12935-026-04311-5","journal-title":"Cancer Cell Int"},{"issue":"4","key":"5955_CR16","doi-asserted-by":"publisher","first-page":"947","DOI":"10.3390\/biomedicines14040947","volume":"14","author":"ED Muntean","year":"2026","unstructured":"Muntean ED, Laz\u0103r D-C, Pah A-M, Banciu C, Chiriac S-D, Boant\u0103 ID et al (2026) Synergistic interactions between medicinal plant bioactive and standard chemotherapy in gastric cancer: preclinical evidence and translational pitfalls. Biomedicines 14(4):947","journal-title":"Biomedicines"},{"issue":"4","key":"5955_CR17","doi-asserted-by":"publisher","DOI":"10.3390\/ph19040613","volume":"19","author":"Y \u00d6zalp","year":"2026","unstructured":"\u00d6zalp Y, Alloush T, Serak\u0131nc\u0131 N, Kartal M (2026) Berberine as a multifunctional adjuvant in cancer therapy: mechanistic insights, nanotechnological strategies, and translational challenges. Pharmaceuticals (Basel) 19(4):613","journal-title":"Pharmaceuticals (Basel)"},{"key":"5955_CR18","doi-asserted-by":"crossref","unstructured":"Or C-HR, Huang C-W, Chang C-C, Lai Y-C, Chen Y-J, Chang C-C (2020) Obatoclax, a pan-BCL-2 inhibitor, downregulates survivin to induce apoptosis in human colorectal carcinoma cells via suppressing WNT\/\u03b2-catenin signaling. Int J Mol Sci 21(5):1773","DOI":"10.3390\/ijms21051773"},{"key":"5955_CR19","doi-asserted-by":"publisher","first-page":"1808500","DOI":"10.3389\/fcell.2026.1808500","volume":"14","author":"R Prabhakaran","year":"2026","unstructured":"Prabhakaran R, Muthu R, Mahendran K, Thamarai R, Subramanian V, Revathi S et al (2026) Epigenetic regulation of the \u03b2-catenin pathway in cadmium-induced colorectal cancer progression and chemoresistance. Front Cell Dev Biol 14:1808500","journal-title":"Front Cell Dev Biol"},{"key":"5955_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2026.1741800","volume":"13","author":"C Psvv","year":"2026","unstructured":"Psvv C, Sunil S, Thuyyath N, Kokkanti RR, Lavudi K (2026) Mitochondrial metabolism in cancer stem cells (CSCs): molecular and diagnostic implications. Front Mol Biosci 13:1741800","journal-title":"Front Mol Biosci"},{"key":"5955_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2026.1820481","volume":"17","author":"PS Ramalingam","year":"2026","unstructured":"Ramalingam PS, Ilma B, Hussain MS, Jakhmola V, Fatima R, Rana AJ et al (2026) The central role of EMT in tumor progression: mechanistic drivers, biomarker discovery, and therapeutic horizons. Front Pharmacol 17:1820481","journal-title":"Front Pharmacol"},{"key":"5955_CR22","doi-asserted-by":"publisher","DOI":"10.2174\/0113895575415295250922074231","author":"A Saha","year":"2025","unstructured":"Saha A, Sarkar P, Mukherjee D, Bhadra K (2025) Targeting chemical-induced hepatocellular carcinoma: ameliorative potential of natural compounds with focus on beta-carbolines. Mini-Rev Med Chem. https:\/\/doi.org\/10.2174\/0113895575415295250922074231","journal-title":"Mini-Rev Med Chem"},{"issue":"1","key":"5955_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines14010215","volume":"14","author":"AK Sah","year":"2026","unstructured":"Sah AK, Das J, Umarovich AI, Agarwal S, Prabhakar PK, Vashishtha A et al (2026) Targeting cancer stem cells with phytochemicals: molecular mechanisms and therapeutic potential. Biomedicines 14(1):215","journal-title":"Biomedicines"},{"key":"5955_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1633699","volume":"15","author":"R Shi","year":"2025","unstructured":"Shi R, Cao Z, Li J, Ji R, Guo Z (2025) Targeting the Wnt\/\u03b2-catenin pathway and epithelial-mesenchymal transition in gastric cancer: mechanisms, therapeutic strategies, and clinical challenges. Front Oncol 15:1633699","journal-title":"Front Oncol"},{"key":"5955_CR25","first-page":"385","volume-title":"Exploring Herbal Synergies for Optimal Human Health","author":"S Sivaji","year":"2026","unstructured":"Sivaji S, Thangavelu S, Seetharaman B, Jayaraman L, Kaur J, Dhar SK (2026) Synergistic effects of multi-herbal and herb\u2013drug combinations and their molecular mechanisms of action and clinical relevance. Exploring Herbal Synergies for Optimal Human Health. CRC Press, pp 385\u2013410"},{"issue":"1","key":"5955_CR26","doi-asserted-by":"publisher","first-page":"6359088","DOI":"10.1155\/bmri\/6359088","volume":"2026","author":"M Sohel","year":"2026","unstructured":"Sohel M, Aktar S, Khatun S, Hamidu S, Nity NU, Kumar S et al (2026) A narrative review on unravelling bacterial-mediated carcinogenesis and possible alternative treatment strategies. Biomed Res Int 2026(1):6359088","journal-title":"Biomed Res Int"},{"issue":"10","key":"5955_CR27","doi-asserted-by":"publisher","first-page":"69","DOI":"10.53388\/TMR20250910001","volume":"11","author":"X Wei","year":"2026","unstructured":"Wei X, Yao J, Liang S (2026) Mechanisms of anticancer active molecules from traditional Chinese medicine and strategies for clinical application. Tradit Med Res 11(10):69","journal-title":"Tradit Med Res"},{"key":"5955_CR28","doi-asserted-by":"publisher","DOI":"10.1177\/09731296261436883","author":"Z Wu","year":"2026","unstructured":"Wu Z, Xie W (2026) Quercetin suppresses gastric cancer progression through inhibition of cell proliferation, migration, and tumor growth. Pharmacogn Mag. https:\/\/doi.org\/10.1177\/09731296261436883","journal-title":"Pharmacogn Mag"},{"issue":"1","key":"5955_CR29","first-page":"245","volume":"46","author":"Y Wu","year":"2026","unstructured":"Wu Y, Yinghui L, Heng L (2026) Molecular landscape of Berberine\u2019s therapeutic potential in gastrointestinal disorders. J Tradit Chin Med 46(1):245","journal-title":"J Tradit Chin Med"},{"key":"5955_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2026.157765","author":"G Xu","year":"2026","unstructured":"Xu G, Yang Q, Zhang S, Ma G, Wang Y, Huang Y et al (2026) Berberine promotes \u03b2-catenin ubiquitination and inhibits its nuclear translocation by targeting USP22 in colorectal cancers. Phytomedicine. https:\/\/doi.org\/10.1016\/j.phymed.2026.157765","journal-title":"Phytomedicine"},{"issue":"1","key":"5955_CR31","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41392-025-02342-4","volume":"11","author":"J Yang","year":"2026","unstructured":"Yang J, Wang S, Li X, Xu H, Sun T, Hu T et al (2026) Signaling pathways and targeted interventions for precancers. Signal Transduct Target Ther 11(1):9","journal-title":"Signal Transduct Target Ther"},{"key":"5955_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1560714","volume":"16","author":"S Zeng","year":"2025","unstructured":"Zeng S, Wang J, Shi Z, Zhao H, Gao J, Li J (2025) The Wnt\/\u03b2-catenin signaling pathway in colorectal cancer: mechanism and intervention of traditional Chinese medicine and chemical compound. Front Pharmacol 16:1560714","journal-title":"Front Pharmacol"},{"key":"5955_CR33","doi-asserted-by":"crossref","unstructured":"Zhang C, Yu Y, Dai S, Liu D, Zhou M, Zhang J et al (2026) Therapeutic regulation of the Wnt\/\u03b2-catenin pathway by traditional Chinese medicine: emerging strategies in atherosclerosis management","DOI":"10.22541\/au.177452357.77869690\/v1"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05955-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-05955-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-05955-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:50:55Z","timestamp":1791510655000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00210-026-05955-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,9]]},"references-count":33,"alternative-id":["5955"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-05955-w","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,9]]},"assertion":[{"value":"13 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was conducted in accordance with internationally accepted ethical standards for biomedical research. The experiments were performed exclusively using established cell lines. No human participants or animal subjects were involved, and therefore, ethical approval and informed consent were not required for this study.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}