{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T08:34:10Z","timestamp":1793003650713,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Naunyn-Schmiedeberg's Arch Pharmacol"],"DOI":"10.1007\/s00210-026-06027-9","type":"journal-article","created":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:56:27Z","timestamp":1792806987000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacological interactions of carvedilol and curcumin nanomicelles in spontaneously hypertensive rats: a bliss and HSA analysis"],"prefix":"10.1007","author":[{"given":"Yanina Alejandra Santander","family":"Plantamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Allo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Riedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Sol","family":"Riesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Carranza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Donato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Garces","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Evelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezequiel","family":"Bernabeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Chiappetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Gorzalczany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"H\u00f6cht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,24]]},"reference":[{"issue":"1","key":"6027_CR1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.pharep.2013.08.006","volume":"66","author":"D Andrzejczak","year":"2014","unstructured":"Andrzejczak D, G\u00f3rska D (2014) The effects of celiprolol on serum concentrations of proinflammatory cytokines in hypertensive (SHR) and normotensive (WKY) rats. Pharmacol Rep 66(1):68\u201373. https:\/\/doi.org\/10.1016\/j.pharep.2013.08.006","journal-title":"Pharmacol Rep"},{"key":"6027_CR2","doi-asserted-by":"publisher","DOI":"10.15212\/CVIA.2025.0035","author":"L Askin","year":"2026","unstructured":"Askin L, Tanr\u0131verdi O, Kaya E, Poyraz F, Baris VO (2026) Integrative mechanisms of osteoprotegerin in cardiovascular pathophysiology. Cardiovasc Innov Appl. https:\/\/doi.org\/10.15212\/CVIA.2025.0035","journal-title":"Cardiovasc Innov Appl"},{"key":"6027_CR3","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0031-6997(25)00026-2","volume":"41","author":"MC Berenbaum","year":"1989","unstructured":"Berenbaum MC (1989) What is synergy? Pharmacol Rev 41:93\u2013141. https:\/\/doi.org\/10.1016\/S0031-6997(25)00026-2","journal-title":"Pharmacol Rev"},{"issue":"2","key":"6027_CR4","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3109\/10715762.2013.845294","volume":"48","author":"FM Bertera","year":"2014","unstructured":"Bertera FM, Santa-Cruz DM, Balestrasse KB, Gorzalczany SB, H\u00f6cht C, Taira CA, Polizio AH (2014) Tempol-nebivolol therapy potentiates hypotensive effect increasing NO bioavailability and signaling pathway. Free Radic Res 48(2):109\u2013118. https:\/\/doi.org\/10.3109\/10715762.2013.845294","journal-title":"Free Radic Res"},{"key":"6027_CR5","doi-asserted-by":"crossref","unstructured":"Borisy AA, Elliott PJ, Hurst NW, Lee MS, Leh\u00e1 J, Price ER, Serbedzija G, Zimmermann GR, Foley MA, Stockwell BR, Keith CT (2003) Systematic discovery of multicomponent therapeutics. In PNAS, 100(13). www.pnas.orgcgi10.1073pnas.1337088100","DOI":"10.1073\/pnas.1337088100"},{"issue":"10296","key":"6027_CR6","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0140-6736(21)00221-X","volume":"398","author":"S Brouwers","year":"2021","unstructured":"Brouwers S, Sudano I, Kokubo Y, Sulaica EM (2021) Arterial hypertension. Lancet 398(10296):249\u2013261. https:\/\/doi.org\/10.1016\/S0140-6736(21)00221-X","journal-title":"Lancet"},{"issue":"2","key":"6027_CR7","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/cjoc.202200406","volume":"41","author":"L Chen","year":"2023","unstructured":"Chen L, Jiang Z, Yang L, Fang Y, Lu S, Akakuru OU, Huang S, Li J, Ma S, Wu A (2023) HPDA\/Zn as a CREB inhibitor for ultrasound imaging and stabilization of atherosclerosis plaque\u2020. Chin J Chem 41(2):199\u2013206. https:\/\/doi.org\/10.1002\/cjoc.202200406","journal-title":"Chin J Chem"},{"key":"6027_CR8","doi-asserted-by":"crossref","unstructured":"Dandona P, Ghanim H, Brooks DP (2007) Antioxidant activity of carvedilol in cardiovascular disease. In J Hypertension 25. Lippincott Williams & Wilkins","DOI":"10.1097\/HJH.0b013e3280127948"},{"issue":"3","key":"6027_CR9","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1097\/HJH.0000000000002284","volume":"38","author":"JS Del Mauro","year":"2020","unstructured":"Del Mauro JS, Prince PD, Allo MA, Santander Plantamura Y, Morett\u00f3n MA, Gonz\u00e1lez GE, Bertera FM, Carranza A, Gorzalczany SB, Chiappetta DA, Morales C, Gelpi RJ, Taira CA, Polizio AH, Donato M, H\u00f6cht C (2020) Effects of third-generation \u03b2-blockers, atenolol or amlodipine on blood pressure variability and target organ damage in spontaneously hypertensive rats. J Hypertens 38(3):536\u2013545. https:\/\/doi.org\/10.1097\/HJH.0000000000002284","journal-title":"J Hypertens"},{"issue":"1","key":"6027_CR10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1586\/erc.11.166","volume":"10","author":"JJ DiNicolantonio","year":"2012","unstructured":"DiNicolantonio JJ, Hackam DG (2012) Carvedilol: a third-generation \u03b2-blocker should be a first-choice \u03b2-blocker. Expert Rev Cardiovasc Ther 10(1):13\u201325. https:\/\/doi.org\/10.1586\/erc.11.166","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"6027_CR11","doi-asserted-by":"publisher","unstructured":"Gonz\u00e1lez-Correa C, Mi\u00f1ano S, Mole\u00f3n J, Toral M, Robles-Vera I, S\u00e1nchez M, Jim\u00e9nez R, Olivares M, Mart\u00edn-Morales N, O\u2019Valle F, Guerra-Hern\u00e1ndez E, Romero M, G\u00f3mez-Guzm\u00e1n M, Duarte J (2025) The probiotic Limosilactobacillus fermentum CECT5716 enhances the antihypertensive response to hydrochlorothiazide in spontaneously hypertensive rats. Gut Microbes 17(1). https:\/\/doi.org\/10.1080\/19490976.2025.2586324","DOI":"10.1080\/19490976.2025.2586324"},{"key":"6027_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/biom16020286","author":"B Guo","year":"2026","unstructured":"Guo B, Fu Y, Wang M, Zhu L, He X (2026) STAT-mediated mitochondrial regulation in cardiovascular diseases: mechanistic insights and STAT3-focused therapeutic strategies. Biomolecules. https:\/\/doi.org\/10.3390\/biom16020286","journal-title":"Biomolecules"},{"issue":"4","key":"6027_CR13","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1161\/HYPERTENSIONAHA.117.07802","volume":"70","author":"TJ Guzik","year":"2017","unstructured":"Guzik TJ, Touyz RM (2017) Oxidative stress, inflammation, and vascular aging in hypertension. Hypertension 70(4):660\u2013667. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.117.07802","journal-title":"Hypertension"},{"issue":"2","key":"6027_CR14","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.abb.2008.01.028","volume":"476","author":"B Halliwell","year":"2008","unstructured":"Halliwell B (2008) Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Arch Biochem Biophys 476(2):107\u2013112. https:\/\/doi.org\/10.1016\/j.abb.2008.01.028","journal-title":"Arch Biochem Biophys"},{"key":"6027_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2019.07.003","author":"Y Han","year":"2019","unstructured":"Han Y, Sun HJ, Tong Y, Chen YZ, Ye C, Qiu Y, Zhang F, Chen AD, Qi XH, Chen Q, Li YH, Kang YM, Zhu GQ (2019) Curcumin attenuates migration of vascular smooth muscle cells via inhibiting NF\u03baB-mediated NLRP3 expression in spontaneously hypertensive rats. J Nutr Biochem. https:\/\/doi.org\/10.1016\/j.jnutbio.2019.07.003","journal-title":"J Nutr Biochem"},{"key":"6027_CR16","doi-asserted-by":"publisher","unstructured":"Hu JJ, Feng SY, Wu L, He SY, Chen XF, Li GH, Min Y, Xu HL, Sun QS, Xie S, Jian-Liu, Chen F, Liu KX, Deng F (2026) Chac1 deficiency confers sepsis resistance by enriching gut microbiota-derived indole-3-carboxylic acid to drive macrophage metabolic shifts. J Adv Res. https:\/\/doi.org\/10.1016\/j.jare.2026.04.065","DOI":"10.1016\/j.jare.2026.04.065"},{"key":"6027_CR17","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000158419.98675.d7","author":"TW Kurtz","year":"2005","unstructured":"Kurtz TW, Griffin KA, Bidani AK, Davisson RL, Hall JE (2005) Recommendations for blood pressure measurement in humans and experimental animals. Arterioscler Thromb Vasc Biol. https:\/\/doi.org\/10.1161\/01.atv.0000158419.98675.d7","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"6027_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155635","author":"Z Lan","year":"2024","unstructured":"Lan Z, Tan F, He J, Liu J, Lu M, Hu Z, Zhuo Y, Liu JJ, Tang X, Jiang Z, Lian A, Chen Y, Huang Y (2024) Curcumin-primed olfactory mucosa-derived mesenchymal stem cells mitigate cerebral ischemia\/reperfusion injury-induced neuronal PANoptosis by modulating microglial polarization. Phytomedicine. https:\/\/doi.org\/10.1016\/j.phymed.2024.155635","journal-title":"Phytomedicine"},{"issue":"10","key":"6027_CR19","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1093\/ajh\/hpv017","volume":"28","author":"RM Lataro","year":"2015","unstructured":"Lataro RM, Silva CAA, Tef\u00e9-Silva C, Prado CM, Salgado HC (2015) Acetylcholinesterase inhibition attenuates the development of hypertension and inflammation in spontaneously hypertensive rats. Am J Hypertens 28(10):1201\u20131208. https:\/\/doi.org\/10.1093\/ajh\/hpv017","journal-title":"Am J Hypertens"},{"key":"6027_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01384","author":"S Lederer","year":"2019","unstructured":"Lederer S, Dijkstra TMH, Heskes T (2019) Additive dose response models: defining synergy. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2019.01384","journal-title":"Front Pharmacol"},{"key":"6027_CR21","doi-asserted-by":"publisher","unstructured":"Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz A-G, Ahn B-W, Shaltiel S, Stadtman ER (1990) Determination of carbonyl content in oxidatively modified proteins. In Methods in enzymology, Vol 186, pp 464\u2013478. https:\/\/doi.org\/10.1016\/0076-6879(90)86141-H","DOI":"10.1016\/0076-6879(90)86141-H"},{"key":"6027_CR22","doi-asserted-by":"publisher","first-page":"8345","DOI":"10.2147\/IJN.S219670","volume":"14","author":"WQ Li","year":"2019","unstructured":"Li WQ, Wu JY, Xiang DX, Luo SL, Hu XB, Tang TT, Sun TL, Liu XY (2019) Micelles loaded with puerarin and modified with triphenylphosphonium cation possess mitochondrial targeting and demonstrate enhanced protective effect against isoprenaline-induced H9c2 cells apoptosis. Int J Nanomedicine 14:8345\u20138360. https:\/\/doi.org\/10.2147\/IJN.S219670","journal-title":"Int J Nanomedicine"},{"key":"6027_CR23","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1577757","author":"H Li","year":"2025","unstructured":"Li H, Li F, Zhou Y, Xiang Z, Zhou B, Lan B, Ruan X (2025) The pharmacokinetics effects of the MCAO model on senkyunolide I in pseudo germ-free rats after oral co-administration of Chuanxiong and warfarin. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2025.1577757","journal-title":"Front Pharmacol"},{"key":"6027_CR24","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6085515","author":"MY Medina-Piza\u00f1o","year":"2022","unstructured":"Medina-Piza\u00f1o MY, Medina-Rosales MN, Mart\u00ednez-Hern\u00e1ndez SL, Aldaba-Muruato LR, Mac\u00cdas-P\u00e9rez JR, S\u00e1nchez-Alem\u00e1n E, Ventura-Ju\u00e1rez J, Mu\u00f1oz-Ortega MH (2022) Protective effect of curcumin against doxazosin- and carvedilol-induced oxidative stress in HepG2 cells. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2022\/6085515","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"6027_CR25","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","volume":"16","author":"KT Mills","year":"2020","unstructured":"Mills KT, Stefanescu A, He J (2020) The global epidemiology of hypertension. Nat Rev Nephrol 16(4):223\u2013237. https:\/\/doi.org\/10.1038\/s41581-019-0244-2","journal-title":"Nat Rev Nephrol"},{"key":"6027_CR26","doi-asserted-by":"publisher","unstructured":"Mirhafez SR, Farimani AR, Gholami A, Hooshmand E, Tavallaie S, Nobakht Gh FFM (2019) The effect of curcumin with piperine supplementation on pro-oxidant and antioxidant balance in patients with non-alcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial. Drug Metab Personalized Ther 34(2). https:\/\/doi.org\/10.1515\/dmpt-2018-0040","DOI":"10.1515\/dmpt-2018-0040"},{"issue":"3","key":"6027_CR27","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.cjca.2012.01.017","volume":"28","author":"AC Montezano","year":"2012","unstructured":"Montezano AC, Touyz RM (2012) Molecular mechanisms of hypertension-reactive oxygen species and antioxidants: a basic science update for the clinician. Can J Cardiol 28(3):288\u2013295. https:\/\/doi.org\/10.1016\/j.cjca.2012.01.017","journal-title":"Can J Cardiol"},{"issue":"9","key":"6027_CR28","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.recesp.2012.03.020","volume":"65","author":"P Morillas","year":"2012","unstructured":"Morillas P, De Andrade H, Castillo J, Quiles J, Bertomeu-Gonz\u00e1lez V, Cordero A, Taraz\u00f3n E, Rosell\u00f3 E, Portol\u00e9s M, Rivera M, Bertomeu-Mart\u00ednez V (2012) Inflamaci\u00f3n y apoptosis en la hipertensi\u00f3n arterial. Importancia de la extensi\u00f3n de la lesi\u00f3n de \u00f3rgano diana. Rev Esp Cardiol 65(9):819\u2013825. https:\/\/doi.org\/10.1016\/j.recesp.2012.03.020","journal-title":"Rev Esp Cardiol"},{"key":"6027_CR29","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2424907","author":"G Musso","year":"2024","unstructured":"Musso G, Alberto M, Mariano F, Cassader M, De Michieli F, Riva A, Petrangolini G, Togni S, Pinach S, Gambino R (2024) Impaired postprandial GLP-2 response enhances endotoxemia, systemic inflammation, and kidney injury in metabolic dysfunction-associated steatohepatitis (MASH): effect of phospholipid curcumin meriva. Gut Microbes. https:\/\/doi.org\/10.1080\/19490976.2024.2424907","journal-title":"Gut Microbes"},{"key":"6027_CR30","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1152\/ajpcell.00213.2006.-Aged","volume":"292","author":"A Navarro","year":"2007","unstructured":"Navarro A, Boveris A (2007) The mitochondrial energy transduction system and the aging process. Am J Physiol Cell Physiol 292:670\u2013686. https:\/\/doi.org\/10.1152\/ajpcell.00213.2006.-Aged","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"6027_CR31","doi-asserted-by":"publisher","first-page":"4821","DOI":"10.3892\/ol.2018.7988","volume":"15","author":"Z Pan","year":"2018","unstructured":"Pan Z, Zhuang J, Ji C, Cai Z, Liao W, Huang Z (2018) Curcumin inhibits hepatocellular carcinoma growth by targeting VEGF expression. Oncol Lett 15(4):4821\u20134826. https:\/\/doi.org\/10.3892\/ol.2018.7988","journal-title":"Oncol Lett"},{"key":"6027_CR32","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.70125","author":"L Parola","year":"2025","unstructured":"Parola L, Prince PD, Opezzo JAW, Riedel J, Allo M\u00c1, Santander Plantamura YA, Bin EP, Gonz\u00e1lez GE, Carranza A, Donato M, Chiappetta DA, Moretton MA, H\u00f6cht C (2025) Encapsulation of carvedilol in nanomicelles improves central hemodynamics and target organ damage protection in spontaneously hypertensive rats. Pharmacol Res Perspect. https:\/\/doi.org\/10.1002\/prp2.70125","journal-title":"Pharmacol Res Perspect"},{"issue":"3","key":"6027_CR33","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.prp.2003.12.008","volume":"200","author":"LMM Pereira","year":"2004","unstructured":"Pereira LMM, Bezerra DG, Mandarim-de-Lacerda CA (2004) Aortic wall remodeling in rats with nitric oxide deficiency treated by enalapril or verapamil. Pathol Res Pract 200(3):211\u2013217. https:\/\/doi.org\/10.1016\/j.prp.2003.12.008","journal-title":"Pathol Res Pract"},{"issue":"4","key":"6027_CR34","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1093\/ajh\/hpu181","volume":"28","author":"RKE Poortvliet","year":"2015","unstructured":"Poortvliet RKE, Lloyd SM, Ford I, Sattar N, De Craen AJM, Wijsman LW, Mooijaart SP, Westendorp RGJ, Jukema JW, Ruijter WD, Gussekloo J, Stott DJ (2015) Biological correlates of blood pressure variability in elderly at high risk of cardiovascular disease. Am J Hypertens 28(4):469\u2013479. https:\/\/doi.org\/10.1093\/ajh\/hpu181","journal-title":"Am J Hypertens"},{"key":"6027_CR35","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1152\/ajpgi.90428.2008.-Human","volume":"296","author":"P Rafiee","year":"2009","unstructured":"Rafiee P, Nelson VM, Manley S, Wellner M, Floer M, Binion DG, Shaker R (2009) Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-B. Am J Physiol Gastrointest Liver Physiol 296:388\u2013398. https:\/\/doi.org\/10.1152\/ajpgi.90428.2008.-Human","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"5","key":"6027_CR36","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1161\/01.HYP.37.5.1199","volume":"37","author":"JF Reckelhoff","year":"2001","unstructured":"Reckelhoff JF (2001) Gender differences in the regulation of blood pressure. Hypertension 37(5):1199\u20131208. https:\/\/doi.org\/10.1161\/01.HYP.37.5.1199","journal-title":"Hypertension"},{"key":"6027_CR37","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-03537-2","author":"YA Santander Plantamura","year":"2024","unstructured":"Santander Plantamura YA, Allo M, Riedel J, Fuentes P, Riesco AS, Bernabeu E, Garc\u00e9s M, Evelson P, Gorzalczany S, Carranza A, H\u00f6cht C, Chiappetta D (2024) Development of a new micellar formulation of carvedilol and curcumin to enhance blood pressure reduction in a spontaneously hypertensive rat model. Naunyn Schmiedebergs Arch Pharmacol. https:\/\/doi.org\/10.1007\/s00210-024-03537-2","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"5","key":"6027_CR38","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/S0894-7317(89)80014-8","volume":"2","author":"NB Schiller","year":"1989","unstructured":"Schiller NB, Shah PM, Crawford M, DeMaria A, Devereux R, Feigenbaum H, Gutgesell H, Reichek N, Sahn D, Schnittger I, Silverman NH, Tajik AJ (1989) Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. J Am Soc Echocardiogr 2(5):358\u2013367. https:\/\/doi.org\/10.1016\/S0894-7317(89)80014-8","journal-title":"J Am Soc Echocardiogr"},{"issue":"2","key":"6027_CR39","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.hermed.2015.03.001","volume":"5","author":"A Siviero","year":"2015","unstructured":"Siviero A, Gallo E, Maggini V, Gori L, Mugelli A, Firenzuoli F, Vannacci A (2015) Curcumin, a golden spice with a low bioavailability. J Herb Med 5(2):57\u201370. https:\/\/doi.org\/10.1016\/j.hermed.2015.03.001","journal-title":"J Herb Med"},{"issue":"1","key":"6027_CR40","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1177\/1074248417725058","volume":"23","author":"M Skrzypiec-Spring","year":"2018","unstructured":"Skrzypiec-Spring M, Haczkiewicz K, Sapa A, Piasecki T, Kwiatkowska J, Ceremuga I, Wozniak M, Biczysko W, Kobierzycki C, Dziegiel P, Podhorska-Okolow M, Szelag A (2018) Carvedilol inhibits matrix metalloproteinase-2 activation in experimental autoimmune myocarditis: possibilities of cardioprotective application. J Cardiovasc Pharmacol Ther 23(1):89\u201397. https:\/\/doi.org\/10.1177\/1074248417725058","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"6027_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173690","author":"TL Sun","year":"2021","unstructured":"Sun TL, Li WQ, Tong XL, Liu XY, Zhou WH (2021) Xanthohumol attenuates isoprenaline-induced cardiac hypertrophy and fibrosis through regulating PTEN\/AKT\/mTOR pathway. Eur J Pharmacol. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173690","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"6027_CR42","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.coph.2012.12.002","volume":"13","author":"PM Vanhoutte","year":"2013","unstructured":"Vanhoutte PM, Gao Y (2013) Beta blockers, nitric oxide, and cardiovascular disease. Curr Opin Pharmacol 13(2):265\u2013273. https:\/\/doi.org\/10.1016\/j.coph.2012.12.002","journal-title":"Curr Opin Pharmacol"},{"key":"6027_CR43","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202200554","author":"Y Wang","year":"2023","unstructured":"Wang Y, Zhai W, Zhang H, Cheng S, Li J (2023) Injectable polyzwitterionic lubricant for complete prevention of cardiac adhesion. Macromol Biosci. https:\/\/doi.org\/10.1002\/mabi.202200554","journal-title":"Macromol Biosci"},{"key":"6027_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110525","author":"A Xu","year":"2020","unstructured":"Xu A, Deng F, Chen Y, Kong Y, Pan L, Liao Q, Rao Z, Xie L, Yao C, Li S, Zeng X, Zhu X, Liu H, Gao N, Xue L, Chen F, Xu G, Wei D, Zhou X, Li Z, Sheng X (2020) NF-\u03baB pathway activation during endothelial-to-mesenchymal transition in a rat model of doxorubicin-induced cardiotoxicity. Biomed Pharmacother. https:\/\/doi.org\/10.1016\/j.biopha.2020.110525","journal-title":"Biomed Pharmacother"},{"key":"6027_CR45","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.csbj.2015.09.001","volume":"13","author":"B Yadav","year":"2015","unstructured":"Yadav B, Wennerberg K, Aittokallio T, Tang J (2015) Searching for drug synergy in complex dose-response landscapes using an interaction potency model. Comput Struct Biotechnol J 13:504\u2013513. https:\/\/doi.org\/10.1016\/j.csbj.2015.09.001","journal-title":"Comput Struct Biotechnol J"},{"key":"6027_CR46","first-page":"105","volume":"39","author":"K Yagi","year":"1968","unstructured":"Yagi K, Nishigaki I, Ohama H (1968) A simple fluorometric assay for lipoperoxide in blood plasma. Vitamins 39:105","journal-title":"Vitamins"},{"key":"6027_CR47","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2531210","author":"X Zhang","year":"2025","unstructured":"Zhang X, Cui Q, Yin L, Zhu J, Mao Y, Yin R, Shao H, Wang W, Sun X, Zhang Z, Gu C, Zhang M, Zhang R, Lu H, Cai Z, Li H, Yang Z (2025) Ginger-derived vesicle-like nanoparticles loaded with curcumin to alleviate ionizing radiation-induced intestinal damage via gut microbiota regulation. Gut Microbes. https:\/\/doi.org\/10.1080\/19490976.2025.2531210","journal-title":"Gut Microbes"}],"container-title":["Naunyn-Schmiedeberg's Archives of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-06027-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-06027-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00210-026-06027-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T08:01:55Z","timestamp":1793001715000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00210-026-06027-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,24]]},"references-count":47,"alternative-id":["6027"],"URL":"https:\/\/doi.org\/10.1007\/s00210-026-06027-9","relation":{},"ISSN":["0028-1298","1432-1912"],"issn-type":[{"value":"0028-1298","type":"print"},{"value":"1432-1912","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,24]]},"assertion":[{"value":"28 August 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}