{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T13:44:19Z","timestamp":1786801459169,"version":"build-2736575974"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2005,1,29]],"date-time":"2005-01-29T00:00:00Z","timestamp":1106956800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2005,6]]},"DOI":"10.1007\/s00213-004-2134-x","type":"journal-article","created":{"date-parts":[[2005,1,28]],"date-time":"2005-01-28T12:37:23Z","timestamp":1106915843000},"page":"150-158","source":"Crossref","is-referenced-by-count":19,"title":["Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919)"],"prefix":"10.1007","volume":"180","author":[{"given":"Anke","family":"Post","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Ohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osborne F. X.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth B.","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"R\u00fccker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Welt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Holsboer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Sillaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,1,29]]},"reference":[{"key":"2134_CR1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1096\/fasebj.14.5.779","volume":"14","author":"OFX Almeida","year":"2000","unstructured":"Almeida OFX, Cond\u00e9 GL, Crochemore C, Demeneix BA, Fischer D, Hassan AHS, Meyer M, Holsboer F, Michaelidis TM (2000) Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB 14:779\u2013789","journal-title":"FASEB"},{"key":"2134_CR2","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/S0006-2952(02)00882-1","volume":"63","author":"P Bartholom\u00e4","year":"2002","unstructured":"Bartholom\u00e4 P, Erlandsson N, Kaufmann K, Rossler OG, Baumann B, Wirth T, Giehl KM, Thiel G (2002) Neuronal cell death induced by antidepressants: lack of correlation with Egr-1, NF-kappa B and extracellular signal-regulated protein kinase activation. Biochem Pharmacol 63:1507\u20131516","journal-title":"Biochem Pharmacol"},{"key":"2134_CR3","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1097\/00001756-199804200-00048","volume":"20","author":"N Birbaumer","year":"1998","unstructured":"Birbaumer N, Grodd W, Diedrich O, Klose U, Erb M, Lotze M, Schneider F, Weiss U, Flor H (1998) fMRI reveals amygdala activation to human faces in social phobics. NeuroReport 20:1223\u20131226","journal-title":"NeuroReport"},{"key":"2134_CR4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s002130000468","volume":"151","author":"L Bjartmar","year":"2000","unstructured":"Bjartmar L, Johansson IM, Marcusson J, Ross SB, Seckl JR, Olsson T (2000) Selective effects on NGFI-A, MR, GR and NGFI-B hippocampal mRNA expression after chronic treatment with different subclasses of antidepressants in the rat. Psychopharmacology (Berl) 151:7\u201312","journal-title":"Psychopharmacology (Berl)"},{"key":"2134_CR5","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1172\/JCI115086","volume":"87","author":"LS Brady","year":"1991","unstructured":"Brady LS, Whitfield HJ Jr, Fox RJ, Gold PW, Herkenham M (1991) Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications. J Clin Invest 87:831\u2013837","journal-title":"J Clin Invest"},{"key":"2134_CR6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0006-8993(92)90459-M","volume":"572","author":"LS Brady","year":"1992","unstructured":"Brady LS, Gold PW, Herkenham M, Lynn AB, Whitfield HJ Jr (1992) The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications. Brain Res 572:117\u2013125","journal-title":"Brain Res"},{"key":"2134_CR7","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/00006842-199909000-00004","volume":"61","author":"G Chen","year":"1999","unstructured":"Chen G, Hasanat KA, Bebchuk JM, Moore GJ, Glitz D, Manji HK (1999) Regulation of signal transduction pathways and gene expression by mood stabilizers and antidepressants. Psychosom Med 61:599\u2013617","journal-title":"Psychosom Med"},{"key":"2134_CR8","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1038\/sj.onc.1204547","volume":"20","author":"MJ Coldwell","year":"2001","unstructured":"Coldwell MJ, deSchoolmeester ML, Fraser GA, Pickering BM, Packham G, Willis AE (2001) The p36 isoform of BAG-1 is translated by internal ribosome entry following heat shock. Oncogene 20:4095\u20134100","journal-title":"Oncogene"},{"key":"2134_CR9","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1046\/j.1523-1755.2000.00960.x","volume":"57","author":"A Crocoll","year":"2000","unstructured":"Crocoll A, Schneikert J, Hubner S, Martin E, Cato AC (2000) BAG-1M: a potential specificity determinant of corticosteroid receptor action. Kidney Int 57:1265\u20131269","journal-title":"Kidney Int"},{"key":"2134_CR10","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1073\/pnas.97.8.3919","volume":"97","author":"K Bosscher De","year":"2000","unstructured":"De Bosscher K, Vanden Berghe W, Vermeulen L, Plaisance S, Boone E, Haegeman G (2000) Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell. Proc Natl Acad Sci U S A 97:3919\u20133924","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2134_CR11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1210\/mend.15.2.0591","volume":"15","author":"K Bosscher De","year":"2001","unstructured":"De Bosscher K, Vanden Berghe W, Haegeman G (2001) Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators. Mol Endocrinol 15:219\u2013227","journal-title":"Mol Endocrinol"},{"key":"2134_CR12","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1210\/endo.143.3.8678","volume":"143","author":"EG Santos Dos","year":"2002","unstructured":"Dos Santos EG, Dieudonne MN, Pecquery R, Le Moal V, Giudicelli Y, Lacasa D (2002) Rapid nongenomic E2 effects on p42\/p44 MAPK, activator protein-1, and cAMP response element binding protein in rat white adipocytes. Endocrinology 143:930\u2013940","journal-title":"Endocrinology"},{"key":"2134_CR13","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0079-6123(00)26027-5","volume":"126","author":"WC Drevets","year":"2000","unstructured":"Drevets WC (2000) Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression. Prog Brain Res 126:413\u2013431","journal-title":"Prog Brain Res"},{"key":"2134_CR14","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1124\/jpet.102.042788","volume":"304","author":"DA Gutman","year":"2003","unstructured":"Gutman DA, Owens MJ, Skelton KH, Thrivikraman KV, Nemeroff CB (2003) The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress. J Pharmacol Exp Ther 304:874\u2013880","journal-title":"J Pharmacol Exp Ther"},{"key":"2134_CR15","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1054\/npep.2001.0851","volume":"35","author":"J Harro","year":"2001","unstructured":"Harro J, Tonissaar M, Eller M (2001) The effects of CRA 1000, a non-peptide antagonist of corticotropin-releasing factor receptor type 1, on adaptive behaviour in the rat. Neuropeptides 35:100\u2013109","journal-title":"Neuropeptides"},{"key":"2134_CR16","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0893-133X(02)00299-3","volume":"27","author":"SC Heinrichs","year":"2002","unstructured":"Heinrichs SC, De Souza EB, Schulteis G, Lapsansky JL, Grigoriadis DE (2002) Brain penetrance, receptor occupancy and antistress in vivo efficacy of a small molecule corticotropin releasing factor type I receptor selective antagonist. Neuropsychopharmacology 27:194\u2013202","journal-title":"Neuropsychopharmacology"},{"key":"2134_CR17","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1038\/sj.onc.1204388","volume":"30","author":"P Herrlich","year":"2001","unstructured":"Herrlich P (2001) Cross-talk between glucocorticoid receptor and AP-1. Oncogene 30:2465\u20132475","journal-title":"Oncogene"},{"key":"2134_CR18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0022-3956(98)90056-5","volume":"33","author":"F Holsboer","year":"1999","unstructured":"Holsboer F (1999) The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. J Psychiatr Res 33:181\u2013214","journal-title":"J Psychiatr Res"},{"key":"2134_CR19","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0893-133X(00)00159-7","volume":"23","author":"F Holsboer","year":"2000","unstructured":"Holsboer F (2000) The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23:477\u2013501","journal-title":"Neuropsychopharmacology"},{"key":"2134_CR20","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1210\/edrv-17-2-187","volume":"17","author":"F Holsboer","year":"1996","unstructured":"Holsboer F, Barden N (1996) Antidepressants and hypothalamic\u2013pituitary\u2013adrenocortical regulation. Endocr Rev 17:187\u2013205","journal-title":"Endocr Rev"},{"key":"2134_CR21","doi-asserted-by":"crossref","first-page":"34134","DOI":"10.1074\/jbc.274.48.34134","volume":"274","author":"KC Kanelakis","year":"1999","unstructured":"Kanelakis KC, Morishima Y, Dittmar KD, Galigniana MD, Takayama S, Reed JC, Pratt WB (1999) Differential effects of the hsp70-binding protein BAG-1 on glucocorticoid receptor folding by the hsp90-based chaperone machinery. J Biol Chem 274:34134\u201334140","journal-title":"J Biol Chem"},{"key":"2134_CR22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1046\/j.0953-816X.2000.01383.x","volume":"13","author":"ME Keck","year":"2001","unstructured":"Keck ME, Welt T, Wigger A, Renner U, Engelmann M, Holsboer F, Landgraf R (2001) The anxiolytic effect of the CRH(1) receptor antagonist R121919 depends on innate emotionality in rats. Eur J Neurosci 13:373\u2013380","journal-title":"Eur J Neurosci"},{"key":"2134_CR23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0014-2999(96)00337-8","volume":"309","author":"J Lundkvist","year":"1996","unstructured":"Lundkvist J, Chai Z, Teheranian R, Hasanvan H, Bartfai T, Jenck F, Widmer U, Moreau JL (1996) A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity. Eur J Pharmacol 309:195\u2013200","journal-title":"Eur J Pharmacol"},{"key":"2134_CR24","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1210\/mend.13.10.0351","volume":"13","author":"SP Malkoski","year":"1999","unstructured":"Malkoski SP, Dorin RI (1999) Composite glucocorticoid regulation at a functionally defined negative glucocorticoid response element of the human corticotropin-releasing hormone gene. Mol Endocrinol 13:1629\u20131644","journal-title":"Mol Endocrinol"},{"key":"2134_CR25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0303-7207(96)04004-X","volume":"127","author":"SP Malkoski","year":"1997","unstructured":"Malkoski SP, Handanos CM, Dorin RI (1997) Localization of a negative glucocorticoid response element of the human corticotropin releasing hormone gene. Mol Cell Endocrinol 127:189\u2013199","journal-title":"Mol Cell Endocrinol"},{"key":"2134_CR26","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/nn943","volume":"5","author":"CB Nemeroff","year":"2002","unstructured":"Nemeroff CB, Owens MJ (2002) Treatment of mood disorders. Nat Neurosci 5:1068\u20131070","journal-title":"Nat Neurosci"},{"key":"2134_CR27","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1126\/science.6334362","volume":"226","author":"CB Nemeroff","year":"1984","unstructured":"Nemeroff CB, Widerlov E, Bissette G, Walleus H, Karlsson I, Eklund K, Kilts CD, Loosen PT, Vale W (1984) Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 226:1342\u20131344","journal-title":"Science"},{"key":"2134_CR28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","volume":"34","author":"EJ Nestler","year":"2002","unstructured":"Nestler EJ, Barrot M, DiLeone RJ, Eisch AJ, Gold SJ, Monteggia LM (2002) Neurobiology of depression. Neuron 34:13\u201325","journal-title":"Neuron"},{"key":"2134_CR29","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1210\/mend.15.7.0659","volume":"15","author":"M Nishi","year":"2001","unstructured":"Nishi M, Ogawa H, Ito T, Matsuda KI, Kawata M (2001) Dynamic changes in subcellular localization of mineralocorticoid receptor in living cells: in comparison with glucocorticoid receptor using dual-color labeling with green fluorescent protein spectral variants. Mol Endocrinol 15:1077\u20131092","journal-title":"Mol Endocrinol"},{"key":"2134_CR30","first-page":"5","volume":"81","author":"F Ohl","year":"1998","unstructured":"Ohl F, Oitzl MS, Fuchs E (1998) Assessing cognitive functions in tree shrews: visuo-spatial and spatial testing in the home cage. J Neurosci Methods 81:5\u201340","journal-title":"J Neurosci Methods"},{"key":"2134_CR31","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1037\/0735-7044.115.2.429","volume":"115","author":"F Ohl","year":"2001","unstructured":"Ohl F, Toschi N, Wigger A, Henniger MSH, Landgraf R (2001a) Ethological analysis of the dimensions of emotionality in an animal model of inborn hyperanxiety. Behav Neurosci 115:429\u2013436","journal-title":"Behav Neurosci"},{"key":"2134_CR32","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3758\/BF03195393","volume":"33","author":"F Ohl","year":"2001","unstructured":"Ohl F, Holsboer F, Landgraf R (2001b) The modified hole board as differential screen for behavior in rodents. Behav Res Meth Instrum Comput 33:392\u2013397","journal-title":"Behav Res Meth Instrum Comput"},{"key":"2134_CR33","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1046\/j.1460-9568.2003.02436.x","volume":"17","author":"F Ohl","year":"2003","unstructured":"Ohl F, Roedel A, Binder E, Holsboer F (2003) Impact of high and low anxiety on cognitive performance in a modified hole board test in C57BL\/6 and DBA\/2 mice. Eur J Neurosci 17:128\u2013136","journal-title":"Eur J Neurosci"},{"key":"2134_CR34","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1046\/j.1365-2826.1999.00405.x","volume":"11","author":"G Okugawa","year":"1999","unstructured":"Okugawa G, Omori K, Suzukawa J, Fujiseki Y, Kinoshita T, Inagaki C (1999) Long-term treatment with antidepressants increases glucocorticoid receptor binding and gene expression in cultured rat hippocampal neurones. J Neuroendocrinol 11:887\u2013895","journal-title":"J Neuroendocrinol"},{"key":"2134_CR35","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0304-3940(03)00261-1","volume":"22","author":"M Okuyama-Tamura","year":"2003","unstructured":"Okuyama-Tamura M, Mikuni M, Kojima I (2003) Modulation of the human glucocorticoid receptor function by antidepressive compounds. Neurosci Lett 22:206\u2013210","journal-title":"Neurosci Lett"},{"key":"2134_CR36","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1038\/sj.npp.1300267","volume":"28","author":"A Oshima","year":"2003","unstructured":"Oshima A, Flachskamm C, Reul JM, Holsboer F, Linthorst AC (2003) Altered serotonergic neurotransmission but normal hypothalamic\u2013pituitary\u2013adrenocortical axis activity in mice chronically treated with the corticotropin-releasing hormone receptor type 1 antagonist NBI 30775. Neuropsychopharmacology 28:2148\u20132159","journal-title":"Neuropsychopharmacology"},{"key":"2134_CR37","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0006-3223(00)01088-X","volume":"49","author":"CM Pariante","year":"2001","unstructured":"Pariante CM, Miller AH (2001) Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol Psychiatry 49:391\u2013404","journal-title":"Biol Psychiatry"},{"key":"2134_CR38","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1124\/mol.52.4.571","volume":"52","author":"CM Pariante","year":"1997","unstructured":"Pariante CM, Pearce BD, Pisell TL, Owens MJ, Miller AH (1997) Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine. Mol Pharmacol 52:571\u2013581","journal-title":"Mol Pharmacol"},{"key":"2134_CR39","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/sj.bjp.0704368","volume":"134","author":"CM Pariante","year":"2001","unstructured":"Pariante CM, Makoff A, Lovestone S, Feroli S, Heyden A, Miller AH, Kerwin RW (2001) Antidepressants enhance glucocorticoid receptor function in vitro by modulating the membrane steroid transporters. Br J Pharmacol 134:1335\u20131343","journal-title":"Br J Pharmacol"},{"key":"2134_CR40","doi-asserted-by":"crossref","unstructured":"Peeters PJ, Gohlmann HW, Van Den Wyngaert I, Swagemakers SM, Bijnens L, Kass SU, Steckler T (2004) Transcriptional response to corticotropin-releasing factor in AtT-20 cells. Mol Pharmacol 22","DOI":"10.1124\/mol.104.000950"},{"key":"2134_CR41","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0169-328X(89)90031-4","volume":"6","author":"MC Pepin","year":"1989","unstructured":"Pepin MC, Beaulieu S, Barden N (1989) Antidepressants regulate glucocorticoid receptor messenger RNA concentrations in primary neuronal cultures. Mol Brain Res 6:77\u201383","journal-title":"Mol Brain Res"},{"key":"2134_CR42","doi-asserted-by":"crossref","first-page":"8236","DOI":"10.1523\/JNEUROSCI.18-20-08236.1998","volume":"15","author":"A Post","year":"1998","unstructured":"Post A, Holsboer F, Behl C (1998) Induction of NF-\u03baB activity during haloperidol-induced oxidative toxicity in clonal hippocampal cells: suppression of NF-\u03baB and neuroprotection by antioxidants. J Neurosci 15:8236\u20138246","journal-title":"J Neurosci"},{"key":"2134_CR43","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1046\/j.0953-816X.2000.01352.x","volume":"12","author":"A Post","year":"2000","unstructured":"Post A, Crochemore C, Uhr M, Holsboer F, Behl C (2000) Differential induction of NF-\u03baB activity and neural cell death by antidepressants in vitro. Eur J Neurosci 12:4331\u20134337","journal-title":"Eur J Neurosci"},{"key":"2134_CR44","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0893-133X(01)00364-5","volume":"26","author":"A Post","year":"2002","unstructured":"Post A, R\u00fccker M, Ohl F, Uhr M, Holsboer F, Almeida OFX, Michaelidis TM (2002) Mechanisms underlying the protective potential of \u03b1-tocopherol (vitamin E) against haloperidol-associated neurotoxicity. Neuropsychopharmacology 26:397\u2013407","journal-title":"Neuropsychopharmacology"},{"key":"2134_CR45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0304-3940(93)90297-X","volume":"161","author":"E Przegalinski","year":"1993","unstructured":"Przegalinski E, Budziszewska B (1993) The effect of long-term treatment with antidepressant drugs on the hippocampal mineralocorticoid and glucocorticoid receptors in rats. Neurosci Lett 161:215\u2013218","journal-title":"Neurosci Lett"},{"key":"2134_CR46","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1471-4892(01)00117-5","volume":"2","author":"JM Reul","year":"2002","unstructured":"Reul JM, Holsboer F (2002) Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol 2:23\u201333","journal-title":"Curr Opin Pharmacol"},{"key":"2134_CR47","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1210\/endo.133.1.8391426","volume":"133","author":"JM Reul","year":"1993","unstructured":"Reul JM, Stec I, Soder M, Holsboer F (1993) Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic\u2013pituitary\u2013adrenocortical system. Endocrinology 133:312\u2013320","journal-title":"Endocrinology"},{"key":"2134_CR48","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1159\/000126788","volume":"60","author":"JM Reul","year":"1994","unstructured":"Reul JM, Labeur MS, Grigoriadis DE, De Souza EB, Holsboer F (1994) Hypothalamic\u2013pituitary\u2013adrenocortical axis changes in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide. Neuroendocrinology 60:509\u2013519","journal-title":"Neuroendocrinology"},{"key":"2134_CR49","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0014-2999(00)00677-4","volume":"405","author":"JM Reul","year":"2000","unstructured":"Reul JM, Gesing A, Droste S, Stec IS, Weber A, Bachmann C, Bilang-Bleuel A, Holsboer F, Linthorst AC (2000) The brain mineralocorticoid receptor: greedy for ligand, mysterious in function. Eur J Pharmacol 405:235\u2013249","journal-title":"Eur J Pharmacol"},{"key":"2134_CR50","doi-asserted-by":"crossref","first-page":"4926","DOI":"10.1074\/jbc.M212000200","volume":"278","author":"U Schmidt","year":"2003","unstructured":"Schmidt U, Wochnik GM, Rosenhagen MC, Young JC, Hartl FU, Holsboer F, Rein T (2003) Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor. J Biol Chem 278:4926\u20134931","journal-title":"J Biol Chem"},{"key":"2134_CR51","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1093\/nar\/17.15.6419","volume":"17","author":"E Schreiber","year":"1989","unstructured":"Schreiber E, Matthias P, M\u00fcller MM, Schaffner W (1989) Rapid detection of octamer binding proteins with mini-extracts, prepared from a small number of cells. Nucleic Acids Res 17:6419","journal-title":"Nucleic Acids Res"},{"key":"2134_CR52","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1159\/000126180","volume":"55","author":"JR Seckl","year":"1992","unstructured":"Seckl JR, Fink G (1992) Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo. Neuroendocrinology 55:621\u2013626","journal-title":"Neuroendocrinology"},{"key":"2134_CR53","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0278-5846(01)00286-X","volume":"26","author":"T Tamura","year":"2002","unstructured":"Tamura T, Morinobu S, Okamoto Y, Kagaya A, Yamawaki S (2002) The effects of antidepressant drug treatments on activator protein-1 binding activity in the rat brain. Prog Neuro-Psychopharmacol Biol Psychiatry 26:375\u2013381","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"2134_CR54","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/520","volume":"19","author":"P Timpl","year":"1998","unstructured":"Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JM, Stalla GK, Blanquet V, Steckler T, Holsboer F, Wurst W (1998) Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nat Genet 19:162\u2013166","journal-title":"Nat Genet"},{"key":"2134_CR55","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0022-3956(00)00016-9","volume":"34","author":"AW Zobel","year":"2000","unstructured":"Zobel AW, Nickel T, Kunzel HE, Ackl N, Sonntag A, Ising M, Holsboer F (2000) Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. J Psychiatr Res 34:171\u2013181","journal-title":"J Psychiatr Res"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-004-2134-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-004-2134-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-004-2134-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T20:01:25Z","timestamp":1558641685000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-004-2134-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,29]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["2134"],"URL":"https:\/\/doi.org\/10.1007\/s00213-004-2134-x","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1,29]]}}}