{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:10:24Z","timestamp":1791220224398,"version":"4.1.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2005,10,18]],"date-time":"2005-10-18T00:00:00Z","timestamp":1129593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1007\/s00213-005-0186-1","type":"journal-article","created":{"date-parts":[[2005,10,17]],"date-time":"2005-10-17T14:17:22Z","timestamp":1129558642000},"page":"481-485","source":"Crossref","is-referenced-by-count":43,"title":["3\u03b1,5\u03b1-THP: a potential plasma neurosteroid biomarker in Alzheimer's disease and perhaps non-Alzheimer's dementia"],"prefix":"10.1007","volume":"186","author":[{"given":"Charles D.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Wekstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Markesbery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl A.","family":"Frye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,10,18]]},"reference":[{"key":"186_CR1","doi-asserted-by":"crossref","first-page":"63\u201365","DOI":"10.1385\/JMN:24:1:063","volume":"24","author":"EE Baulieu","year":"2004","unstructured":"Baulieu EE, Robel P, Fellous A, Duchossoy Y, Fontaine-Lenoir V, David S (2004) MAPREG: toward a novel approach of neuroprotection and treatment of Alzheimer's disease. J Mol Neurosci 24:63\u201365","journal-title":"J Mol Neurosci"},{"key":"186_CR2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pnpbp.2004.11.001","volume":"29","author":"BO Dubrovsky","year":"2005","unstructured":"Dubrovsky BO (2005) Steroids, neuroactive steroids and neurosteroids in psychopathology. Prog Neuropsychopharmacol Biol Psychiatry 29:169\u2013192","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"186_CR3","first-page":"164","volume":"271","author":"DA Finn","year":"1994","unstructured":"Finn DA, Gee KW (1994) The estrus cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid. J Pharmacol Exp Ther 271:164\u2013170","journal-title":"J Pharmacol Exp Ther"},{"key":"186_CR4","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0278-5846(00)00124-X","volume":"24","author":"C Frank","year":"2000","unstructured":"Frank C, Sagratella S (2000) Neuroprotective effects of allopregnenolone on hippocampal irreversible neurotoxicity in vitro. Prog Neuropsychopharmacol Biol Psychiatry 24:1117\u20131126","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"186_CR5","doi-asserted-by":"crossref","first-page":"550","DOI":"10.3758\/BF03332014","volume":"8","author":"CA Frye","year":"2000","unstructured":"Frye CA, Lacey EH (2000) Progestins influence performance on cognitive tasks independent of changes in affective behavior. Psychobiology 8:550\u2013563","journal-title":"Psychobiology"},{"key":"186_CR6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1365-2826.1998.00202.x","volume":"10","author":"CA Frye","year":"1998","unstructured":"Frye CA, Scalise TJ, Bayon LE (1998) Finasteride blocks the reduction in ictal activity produced by exogenous estrous cyclicity. J Neuroendocrinol 10:291\u2013296","journal-title":"J Neuroendocrinol"},{"key":"186_CR7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/nlme.1995.1046","volume":"64","author":"CA Frye","year":"1995","unstructured":"Frye CA, Sturgis JD (1995) Neurosteroids affect spatial\/reference, working, and long-term memory of female rats. Neurobiol Learn Mem 64:83\u201396","journal-title":"Neurobiol Learn Mem"},{"key":"186_CR8","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/ana.10508","volume":"53","author":"AG Herzog","year":"2003","unstructured":"Herzog AG, Frye CA (2003) Seizure exacerbation associated with inhibition of progesterone metabolism. Ann Neurol 53:390\u2013391","journal-title":"Ann Neurol"},{"key":"186_CR9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0165-0173(01)00112-6","volume":"37","author":"T Maurice","year":"2001","unstructured":"Maurice T, Urani A, Phan VL, Romieu P (2001) The interaction between neuroactive steroids and the sigma1 receptor function: behavioral consequences and therapeutic opportunities. Brain Res Brain Res Rev 37:116\u2013132","journal-title":"Brain Res Brain Res Rev"},{"key":"186_CR10","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.pbb.2004.04.021","volume":"78","author":"ME Rhodes","year":"2004","unstructured":"Rhodes ME, McCormick CM, Frye CA (2004) 3alpha,5alpha-THP mediates progestins' effects to protect against adrenalectomy-induced cell death in the dentate gyrus of female and male rats. Pharmacol Biochem Behav 78:505\u2013512","journal-title":"Pharmacol Biochem Behav"},{"key":"186_CR11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.pneurobio.2003.09.004","volume":"71","author":"M Schumacher","year":"2003","unstructured":"Schumacher M, Weill-Engerer S, Liere P, Robert F, Franklin RJ, Garcia-Segura LM, Lambert JJ, Mayo W, Melcangi RC, Parducz A, Suter U, Carelli C, Baulieu EE, Akwa Y (2003) Steroid hormones and neurosteroids in normal and pathological aging of the nervous system. Prog Neurobiol 71:3\u201329","journal-title":"Prog Neurobiol"},{"key":"186_CR12","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1530\/eje.0.1450669","volume":"145","author":"B Stoffel-Wagner","year":"2001","unstructured":"Stoffel-Wagner B (2001) Neurosteroid metabolism in the human brain. Eur J Endocrinol 145:669\u2013679","journal-title":"Eur J Endocrinol"},{"key":"186_CR13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3940(00)01078-8","volume":"286","author":"SJ Twist","year":"2000","unstructured":"Twist SJ, Taylor GA, Weddell A, Weightman DR, Edwardson JA, Morris CM (2000) Brain oestradiol and testosterone levels in Alzheimer's disease. Neurosci Lett 286:1\u20134","journal-title":"Neurosci Lett"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-005-0186-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-005-0186-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-005-0186-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T03:43:46Z","timestamp":1683258226000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-005-0186-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,18]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["186"],"URL":"https:\/\/doi.org\/10.1007\/s00213-005-0186-1","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,18]]}}}