{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:01:37Z","timestamp":1787320897009,"version":"build-2736575974"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2006,7,12]],"date-time":"2006-07-12T00:00:00Z","timestamp":1152662400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1007\/s00213-006-0465-5","type":"journal-article","created":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T06:00:47Z","timestamp":1152597647000},"page":"424-434","source":"Crossref","is-referenced-by-count":23,"title":["Behavioral effects of aminoadamantane class NMDA receptor antagonists on schedule-induced alcohol and self-administration of water in mice"],"prefix":"10.1007","volume":"187","author":[{"given":"Tobie","family":"Escher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanford B.","family":"Call","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles D.","family":"Blaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Mittleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,7,12]]},"reference":[{"key":"465_CR1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1530-0277.1982.tb04999.x","volume":"6","author":"RL Alkana","year":"1982","unstructured":"Alkana RL, Parker ES, Malcolm RD, Cohen HB, Birch H, Noble EP (1982) Interaction of apomorphine and amantadine with alcohol in men. Alcohol Clin Exp Res 6:403\u2013411","journal-title":"Alcohol Clin Exp Res"},{"key":"465_CR2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00213-003-1617-5","volume":"172","author":"A Bisaga","year":"2003","unstructured":"Bisaga A, Evans SM (2003) Acute effects of memantine in combination with alcohol in moderate drinkers. Psychopharmacology 172:16\u201324","journal-title":"Psychopharmacology"},{"key":"465_CR3","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0014-2999(89)90385-3","volume":"166","author":"J Bormann","year":"1989","unstructured":"Bormann J (1989) Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels. Eur J Pharmacol 166:591\u2013592","journal-title":"Eur J Pharmacol"},{"key":"465_CR4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0091-3057(03)00091-1","volume":"75","author":"J Boyce-Rustay","year":"2003","unstructured":"Boyce-Rustay J, Risinger FO (2003) Dopamine D3 receptor knockout mice and the motivational effects of alcohol. Pharmacol Biochem Behav 75:373\u2013379","journal-title":"Pharmacol Biochem Behav"},{"key":"465_CR5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/BF01277656","volume":"104","author":"AR Braun","year":"1997","unstructured":"Braun AR, Laruelle M, Mouradian MM (1997) Interactions between D1 and D2 dopamine receptor family agonists and antagonists: the effects of chronic exposure on behavior and receptor binding in rats and their clinical implications. J Neural Transm 104:341\u2013362","journal-title":"J Neural Transm"},{"key":"465_CR6","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1037\/h0077619","volume":"93","author":"LP Brett","year":"1979","unstructured":"Brett LP, Levine S (1979) Schedule-induced polydipsia suppresses pituitary-adrenal activity in rat. J Comp Physiol Psychol 93:946\u2013956","journal-title":"J Comp Physiol Psychol"},{"key":"465_CR7","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0031-9384(81)90003-2","volume":"26","author":"LP Brett","year":"1981","unstructured":"Brett LP, Levine S (1981) The pituitary-adrenal response to \u201cminimized\u201d schedule-induced drinking. Physiol Behav 26:152\u2013158","journal-title":"Physiol Behav"},{"key":"465_CR8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0014-2999(92)90288-F","volume":"229","author":"M Bubser","year":"1992","unstructured":"Bubser M, Keseberg U, Notz PK, Schmidt WJ (1992) Differential behavioural and neurochemical effects of competitive and non-competitive NMDA receptor antagonists in rats. Eur J Pharmacol 229:75\u201382","journal-title":"Eur J Pharmacol"},{"key":"465_CR9","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.pbb.2004.09.012","volume":"79","author":"R Camarini","year":"2004","unstructured":"Camarini R, Hodge CW (2004) Ethanol preexposure increases ethanol self-administration in C57BL\/6J and DBA\/2J mice. Pharmacol Biochem Behav 79:623\u2013632","journal-title":"Pharmacol Biochem Behav"},{"key":"465_CR10","doi-asserted-by":"crossref","first-page":"16A","DOI":"10.1111\/j.1530-0277.2000.tb00005.x","volume":"24","author":"R Camarini","year":"2000","unstructured":"Camarini R, Mehmert KK, Hodge CW (2000) Effects of alcohol pre-exposure on alcohol self-administration in DBA\/2J and C57BL\/6 mice. Alcohol Clin Exp Res Suppl 24:16A","journal-title":"Alcohol Clin Exp Res Suppl"},{"key":"465_CR11","first-page":"107","volume":"46","author":"HW Clement","year":"1995","unstructured":"Clement HW, Grote C, Svensson L, Engel J, Zofel P, Wesemann W (1995) In vivo studies on the effects of memantine on dopamine metabolism in the striatum and n. accumbens of the rat. J Neural Transm Suppl 46:107\u2013115","journal-title":"J Neural Transm Suppl"},{"key":"465_CR12","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1126\/science.8209252","volume":"264","author":"JC Crabbe","year":"1994","unstructured":"Crabbe JC, Belknap JK, Buck KJ (1994) Genetic animal models of alcohol and drug abuse. Science 264:1715\u20131723","journal-title":"Science"},{"key":"465_CR13","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1530-0277.1995.tb01562.x","volume":"19","author":"RM Crum","year":"1995","unstructured":"Crum RM, Muntaner C, Eaton WW, Anthony JC (1995) Occupational stress and the risk of alcohol abuse and dependence. Alcohol Clin Ex Res 19:647\u2013655","journal-title":"Alcohol Clin Ex Res"},{"key":"465_CR14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0301-0082(99)00031-3","volume":"60","author":"A Dahchour","year":"2000","unstructured":"Dahchour A, De Witte P (2000) Ethanol and amino acids in the central nervous system: assessment of the pharmacological actions of acamprosate. Prog Neurobiol 60:343\u2013362","journal-title":"Prog Neurobiol"},{"key":"465_CR15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0925-4927(98)00016-X","volume":"82","author":"A Dahchour","year":"1998","unstructured":"Dahchour A, DeWitte P, Bolo N, Nedelec J-F, Muzet M, Durbin P, Macher JP (1998) Central effects of acamprosate: part 1. Acamprosate blocks the glutamate increase in the nucleus accumbens microdialysate in alcohol withdrawn rats. Psychiatry Res 82:107\u2013114","journal-title":"Psychiatry Res"},{"key":"465_CR16","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0893-133X(02)00308-1","volume":"27","author":"X Dai","year":"2002","unstructured":"Dai X, Thavundayil J, Gianoulakis C (2002) Response of the hypothalamic-pituitary-adrenal axis to stress in the absence and presence of ethanol in subjects at high and low risk of alcoholism. Neuropsychopharmacology 27:442\u2013452","journal-title":"Neuropsychopharmacology"},{"key":"465_CR17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0031-9384(88)90187-4","volume":"43","author":"R Dantzer","year":"1988","unstructured":"Dantzer R, Terlouw C, Mormede P, Le Moal M (1988) Schedule-induced polydipsia experience decreases plasma corticosterone levels but increases plasma prolactin levels. Physiol Behav 43:275\u2013279","journal-title":"Physiol Behav"},{"key":"465_CR18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0091-3057(94)90506-1","volume":"48","author":"W Danysz","year":"1994","unstructured":"Danysz W, Essmann U, Bresink I, Wilke R (1994) Glutamate antagonists have different effects on spontaneous locomotor activity in rats. Pharmacol Biochem Behav 48:111\u2013118","journal-title":"Pharmacol Biochem Behav"},{"key":"465_CR19","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0149-7634(96)00037-1","volume":"21","author":"W Danysz","year":"1997","unstructured":"Danysz W, Parsons CG, Kornhuber J, Schmidt W, Quack G (1997) Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents\u2014preclinical studies. Neurosci Biobehav Rev 21:455\u2013468","journal-title":"Neurosci Biobehav Rev"},{"key":"465_CR20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0306-4522(01)00047-1","volume":"104","author":"E Leonibus De","year":"2001","unstructured":"De Leonibus E, Mele A, Oliverio A, Pert A (2001) Locomotor activity induced by the non-competitive N-methyl-D-aspartate antagonist, MK-801: role of nucleus accumbens efferent pathways. Neuroscience 104:105\u2013116","journal-title":"Neuroscience"},{"key":"465_CR21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1126\/science.133.3447.195","volume":"133","author":"JL Falk","year":"1961","unstructured":"Falk JL (1961) Production of polydipsia in normal rats by an intermittent food schedule. Science 133:195\u2013196","journal-title":"Science"},{"key":"465_CR22","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0031-9384(71)90209-5","volume":"6","author":"JL Falk","year":"1971","unstructured":"Falk JL (1971) The nature and determinants of adjunctive behavior. Physiol Behav 6:577\u2013588","journal-title":"Physiol Behav"},{"key":"465_CR23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0006-8993(98)00129-2","volume":"792","author":"A Fisher","year":"1998","unstructured":"Fisher A, Biggs CS, Starr MS (1998) Differential effects of NMDA and non-NMDA antagonists on the activity of aromatic L-amino acid decarboxylase activity in the nigrostriatal dopamine pathway of the rat. Brain Res 792:126\u2013132","journal-title":"Brain Res"},{"key":"465_CR24","first-page":"165","volume":"3","author":"LW Fitzgerald","year":"1995","unstructured":"Fitzgerald LW, Nestler EJ (1995) Molecular and cellular adaptations in signal transduction pathways following ethanol exposure. Clin Neurosci 3:165\u2013173","journal-title":"Clin Neurosci"},{"key":"465_CR25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/med.20013","volume":"25","author":"WJ Geldenhuys","year":"2005","unstructured":"Geldenhuys WJ, Malan SF, Bloomquist JR, Marchand AP, Van der Schyf CJ (2005) Pharmacology and structure-activity relationships of bioactive polycyclic cage compounds: a focus on pentacycloundecane derivatives. Med Res Rev 25:21\u201348","journal-title":"Med Res Rev"},{"key":"465_CR26","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1128\/AAC.28.2.216","volume":"28","author":"FG Hayden","year":"1985","unstructured":"Hayden FG, Minocha A, Spyker DA, Hoffman HE (1985) Comparative single-dose pharmacokinetics of amantadine hydrochloride and rimantadine hydrochloride in young and elderly adults. Antimicrob Agents Chemother 28:216\u2013221","journal-title":"Antimicrob Agents Chemother"},{"key":"465_CR28","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/S0006-3223(01)01334-8","volume":"51","author":"CA Hernandez-Avila","year":"2002","unstructured":"Hernandez-Avila CA, Oncken C, Van Kirk J, Wand G, Kranzler HR (2002) Adrenocorticotropin and cortisol responses to a naloxone challenge and risk of alcoholism. Biol Psychiatry 51:652\u2013658","journal-title":"Biol Psychiatry"},{"key":"465_CR27","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s007020050201","volume":"106","author":"HB Hesselink","year":"1999","unstructured":"Hesselink HB, De-Boer AG, Breimer DD, Danysz W (1999) Dopamine release in the prefrontal cortex in response to memantine following sub-chronic NMDA receptor blockade with memantine: a microdialysis study in rats. J Neural Transm 106:803\u2013818","journal-title":"J Neural Transm"},{"key":"465_CR29","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1128\/AAC.32.11.1699","volume":"32","author":"HE Hoffman","year":"1988","unstructured":"Hoffman HE, Gaylord JC, Blasecki JW, Shalaby LM, Whitney CC (1988) Pharmacokinetics and metabolism of rimantadine hydrochloride in mice and dogs. Antimicrob Agents Chemother 32:1699\u20131704","journal-title":"Antimicrob Agents Chemother"},{"key":"465_CR30","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/S0014-2999(96)00670-X","volume":"314","author":"SM Holter","year":"1996","unstructured":"Holter SM, Danysz W, Spanagel R (1996) Evidence for alcohol anti-craving properties of memantine. Eur J Pharmacol 314:R1\u20132","journal-title":"Eur J Pharmacol"},{"key":"465_CR31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1055\/s-2007-979191","volume":"32","author":"TJ Huber","year":"1999","unstructured":"Huber TJ, Dietrich DE, Emrich HM (1999) Possible use of amandine in depression. Pharmacopsychiatry 32:47\u201355","journal-title":"Pharmacopsychiatry"},{"key":"465_CR32","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0006-3223(96)00047-9","volume":"41","author":"J Kornhuber","year":"1997","unstructured":"Kornhuber J, Weller M (1997) Psychotogenicity and N-methyl-D-aspartate receptor antagonism: implications for neuroprotective pharmacotherapy. Biol Psychiatry 41:135\u2013144","journal-title":"Biol Psychiatry"},{"key":"465_CR33","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0922-4106(91)90113-V","volume":"206","author":"J Kornhuber","year":"1991","unstructured":"Kornhuber J, Bormann J, Hubers M, Rusche K, Riederer P (1991) Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor gated ion channel: a human postmortem brain study. Eur J Pharmacol 206:297\u2013300","journal-title":"Eur J Pharmacol"},{"key":"465_CR34","first-page":"91","volume":"43","author":"J Kornhuber","year":"1994","unstructured":"Kornhuber J, Weller M, Schoppmeyer K, Riederer P (1994) Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties. J Neural Transm Suppl 43:91\u2013104","journal-title":"J Neural Transm Suppl"},{"key":"465_CR35","first-page":"47","volume":"53","author":"J Kotlinska","year":"2001","unstructured":"Kotlinska J (2001) NMDA antagonists inhibit the development of alcohol dependence in rats. Pol J Pharmacol 53:47\u201350","journal-title":"Pol J Pharmacol"},{"key":"465_CR36","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1176\/ajp.147.6.685","volume":"147","author":"MG Kushner","year":"1990","unstructured":"Kushner MG, Sher KJ, Beitman BD (1990) The relation between alcohol problems and the anxiety disorders. Am J Psychiatry 147:685\u2013695","journal-title":"Am J Psychiatry"},{"key":"465_CR37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.15288\/jsa.1997.58.341","volume":"58","author":"J Langenbucher","year":"1997","unstructured":"Langenbucher J, Chung T, Morgenstern J, Labouvie E, Nathan PE, Bavly L (1997) Physiological alcohol dependence as a \u201cspecifier\u201d of risk for medical problems and relapse liability in DSM-IV. J Stud Alcohol 58:341\u2013350","journal-title":"J Stud Alcohol"},{"key":"465_CR38","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0006-8993(93)90672-A","volume":"630","author":"A Le","year":"1993","unstructured":"Le A, Poulos CX, Quan B, Chow S (1993) The effects of selective blockade of delta and mu opiate receptors on alcohol consumption by C57BL\/6 mice in a restricted access paradigm. Brain Res 630:330\u2013332","journal-title":"Brain Res"},{"key":"465_CR39","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1037\/0735-7044.103.3.621","volume":"103","author":"R Levine","year":"1989","unstructured":"Levine R, Levine S (1989) Role of the pituitary-adrenal hormones in the acquisition of schedule-induced polydipsia. Behav Neurosci 103:621\u201337","journal-title":"Behav Neurosci"},{"key":"465_CR40","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.3233\/JAD-2004-6S610","volume":"6","author":"SA Lipton","year":"2004","unstructured":"Lipton SA (2004) Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer\u2019s disease and other neurologic disorders. J Alzheimers Dis 6:S61\u2013S74","journal-title":"J Alzheimers Dis"},{"key":"465_CR41","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/j.1360-0443.1995.tb01088.x","volume":"90","author":"J Littleton","year":"1995","unstructured":"Littleton J (1995) Acamprosate in alcohol dependence: how does it work? Addiction 90:1179\u20131188","journal-title":"Addiction"},{"key":"465_CR42","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S0022-3565(24)36659-5","volume":"281","author":"H Matsubayashi","year":"1997","unstructured":"Matsubayashi H, Swanson KL, Albuquerque EX (1997) Amantadine inhibits nicotinic acetylcholine receptor function in hippocampal neurons. J Pharmacol Exp Ther 281:834\u2013844","journal-title":"J Pharmacol Exp Ther"},{"key":"465_CR43","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s002130050491","volume":"135","author":"A Mele","year":"1998","unstructured":"Mele A, Wozniak KM, Hall FS, Pert A (1998) The role of striatal dopaminergic mechanisms in rotational behavior induced by phencyclidine and phencyclidine-like drugs. Psychopharmacology 135:107\u2013118","journal-title":"Psychopharmacology"},{"key":"465_CR44","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF00426387","volume":"82","author":"MK Menon","year":"1984","unstructured":"Menon MK, Vivonia CA, Haddox VG (1984) Evidence for presynaptic antagonism by amantadine of indirectly acting central stimulants. Psychopharmacology 82:89\u201392","journal-title":"Psychopharmacology"},{"key":"465_CR45","first-page":"333","volume":"20","author":"FS Messiha","year":"1977","unstructured":"Messiha FS (1977) Modification of the central depressant action of alcohol by amantadine hydrochloride in the mouse. Proc West Pharmacol Soc 20:333\u2013337","journal-title":"Proc West Pharmacol Soc"},{"key":"465_CR46","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0091-3057(78)90390-8","volume":"8","author":"FS Messiha","year":"1978","unstructured":"Messiha FS (1978) Antagonism of alcohol-evoked responses by amantadine: a possible clinical application. Pharmacol Biochem Behav 8:573\u2013577","journal-title":"Pharmacol Biochem Behav"},{"key":"465_CR47","first-page":"583","volume":"60","author":"S Micuda","year":"2004","unstructured":"Micuda S, Mundlova L, Anzenbacherova E, Anzenbacher P, Chladek J, Fuksa L, Martinkova J (2004) Inhibitory effects of memantine on human cytochrome P450 activities: prediction of in vivo drug interactions. Eur J Pharmacol 60:583\u2013589","journal-title":"Eur J Pharmacol"},{"key":"465_CR48","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1530-0277.1995.tb01485.x","volume":"19","author":"Y Mirovsky","year":"1995","unstructured":"Mirovsky Y, Yu YL, Wagner GC, Sekowski A, Goldberg M, Fisher H (1995) Novel synergistic treatment of ethanol withdrawal seizures in rats with dopamine and serotonin agonists. Alcohol Clin Exp Res 19:160\u2013163","journal-title":"Alcohol Clin Exp Res"},{"key":"465_CR49","first-page":"638","volume":"271","author":"G Mittleman","year":"1994","unstructured":"Mittleman G, Rosner AL, Schaub CL (1994) Polydipsia and dopamine: behavioral effects of dopamine D1 and D2 receptor agonists and antagonists. J Pharmacol Exp Ther 271:638\u2013650","journal-title":"J Pharmacol Exp Ther"},{"key":"465_CR50","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/j.1530-0277.2003.tb04416.x","volume":"27","author":"G Mittleman","year":"2003","unstructured":"Mittleman G, Van Brunt CL, Matthews DB (2003) Schedule-induced alcohol self-administration in DBA\/2J and C57BL\/6J mice. Alcohol Clin Exp Res 27:918\u2013925","journal-title":"Alcohol Clin Exp Res"},{"key":"465_CR51","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0006-8993(94)90821-4","volume":"662","author":"K Mizoguchi","year":"1994","unstructured":"Mizoguchi K, Yokoo H, Yoshida M, Tanaka T, Tanaka M (1994) Amantadine increases the extracellular dopamine levels in the striatum by re-uptake inhibition and by N-methyl-D-aspartate antagonism. Brain Res 662:255\u2013258","journal-title":"Brain Res"},{"key":"465_CR52","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1055\/s-2007-979603","volume":"28","author":"WE Muller","year":"1995","unstructured":"Muller WE, Mutschler E, Riederer P (1995) Noncompetitive NMDA receptor antagonists with fast open-channel blocking kinetics and strong voltage-dependency as potential therapeutic agents for Alzheimer\u2019s dementia. Pharmacopsychiatry 28:113\u2013124","journal-title":"Pharmacopsychiatry"},{"key":"465_CR53","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1600-0773.1984.tb02032.x","volume":"55","author":"E Nuotto","year":"1984","unstructured":"Nuotto E, Mattila MJ (1984) Failure of amantadine and bromocriptine to counteract alcoholic inebriation in man. Acta Pharm Toxicol 55:168\u2013173","journal-title":"Acta Pharm Toxicol"},{"key":"465_CR54","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0014-2999(00)00573-2","volume":"403","author":"G Page","year":"2000","unstructured":"Page G, Peeters M, Maloteaux JM, Hermans E (2000) Increased dopamine uptake in striatal synaptosomes after treatment of rats with amantadine. Eur J Pharmacol 403:75\u201380","journal-title":"Eur J Pharmacol"},{"key":"465_CR55","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/0028-3908(95)00092-K","volume":"34","author":"CG Parsons","year":"1995","unstructured":"Parsons CG, Quack G, Bresink I, Baran L, Przegalinski E, Kostowski W, Krzascik P, Hartmann S, Danysz W (1995) Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo. Neuropharmacology 34:1239\u20131258","journal-title":"Neuropharmacology"},{"key":"465_CR56","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0028-3908(99)00019-2","volume":"38","author":"CG Parsons","year":"1999","unstructured":"Parsons CG, Danysz W, Quack G (1999) Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist\u2014a review of preclinical data. Neuropharmacology 38:735\u2013767","journal-title":"Neuropharmacology"},{"key":"465_CR57","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0006-8993(02)02961-X","volume":"949","author":"M Peeters","year":"2002","unstructured":"Peeters M, Page G, Maloteaux JM, Hermans E (2002) Hypersensitivity of dopamine transmission in the rat striatum after treatment with the NMDA receptor antagonist amantadine. Brain Res 949:32\u201341","journal-title":"Brain Res"},{"key":"465_CR58","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0304-3940(03)00398-7","volume":"343","author":"M Peeters","year":"2003","unstructured":"Peeters M, Maloteaux J-M, Hermans E (2003) Distinct effects of amantadine and memantine on dopaminergic transmission in the rat striatum. Neurosci Lett 343:205\u2013209","journal-title":"Neurosci Lett"},{"key":"465_CR59","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.clpt.2005.10.005","volume":"79","author":"A Periclou","year":"2006","unstructured":"Periclou A, Ventura D, Rao N, Abromowitz W (2006) Pharmacokinetic study of memantine in healthy and renally impaired subjects. Clin Pharmacol Ther 79:134\u2013143","journal-title":"Clin Pharmacol Ther"},{"key":"465_CR60","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0014-2999(98)00442-7","volume":"354","author":"J Piasecki","year":"1998","unstructured":"Piasecki J, Koros E, Dyr W, Kostowski W, Danysz W, Bienkowski P (1998) Alcohol-reinforced behavior in rats: effects of uncompetitive NMDA receptor antagonist, memantine. Eur J Pharmacol 354:135\u2013143","journal-title":"Eur J Pharmacol"},{"key":"465_CR61","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0149-7634(81)90003-8","volume":"5","author":"LA Pohorecky","year":"1981","unstructured":"Pohorecky LA (1981) The interaction of alcohol and stress. A review. Neurosci Biobehav Rev 5:209\u2013229","journal-title":"Neurosci Biobehav Rev"},{"key":"465_CR62","first-page":"97","volume":"46","author":"G Quack","year":"1995","unstructured":"Quack G, Hesselink M, Danysz H, Spanagel R (1995) Microdialysis studies with amantadine and memantine on pharmacokinetics and effects on dopamine turnover. J Neural Transm Suppl 46:97\u2013105","journal-title":"J Neural Transm Suppl"},{"key":"465_CR63","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1530-0277.1998.tb04311.x","volume":"22","author":"FO Risinger","year":"1998","unstructured":"Risinger FO, Brown MM, Doan AM, Oakes RA (1998) Mouse strain differences in oral operant ethanol reinforcement under continuous access conditions. Alcohol Clin Exp Res 22:677\u2013684","journal-title":"Alcohol Clin Exp Res"},{"key":"465_CR64","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0165-6147(93)90005-5","volume":"14","author":"MA Rogawski","year":"1993","unstructured":"Rogawski MA (1993) Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines. Trends Pharmacol Sci 14:325\u2013331","journal-title":"Trends Pharmacol Sci"},{"key":"465_CR65","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0031-9384(79)90159-8","volume":"23","author":"TJ Roper","year":"1979","unstructured":"Roper TJ, Nieto J (1979) Schedule-induced drinking and other behavior in the rat, as a function of body weight deficit. Physiol Behav 23:673\u2013678","journal-title":"Physiol Behav"},{"key":"465_CR66","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0149-7634(96)00044-9","volume":"21","author":"WJ Schmidt","year":"1997","unstructured":"Schmidt WJ, Kretschmer BD (1997) Behavioural pharmacology of glutamate receptors in the basal ganglia. Neurosci Biobehav Rev 21:381\u2013392","journal-title":"Neurosci Biobehav Rev"},{"key":"465_CR67","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.brainresbull.2005.12.001","volume":"69","author":"E Shearman","year":"2006","unstructured":"Shearman E, Rossi S, Szasz B, Juranyi Z, Fallon S, Pomara N, Sershen H, Lajtha A (2006) Changes in cerebral neurotransmitters and metabolites induced by acute donepezil and memantine administrations: a microdialysis study. Brain Res Bull 69:204\u2013213","journal-title":"Brain Res Bull"},{"key":"465_CR68","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/S0022-3565(24)36510-3","volume":"280","author":"KL Shelton","year":"1997","unstructured":"Shelton KL, Balster RL (1997) Effects of \u03b3-aminobutyric acid agonists and N-Methyl-D-aspartate antagonists on a multiple schedule of alcohol and saccharin self-administration in rats. J Pharmacol Exp Ther 280:1250\u20131260","journal-title":"J Pharmacol Exp Ther"},{"key":"465_CR69","first-page":"1214","volume":"283","author":"CT Smothers","year":"1997","unstructured":"Smothers CT, Mrotek JJ, Lovinger DM (1997) Chronic ethanol exposure leads to a selective enhancement of N-methyl-D-aspartate receptor function in cultured hippocampal neurons. J Pharmacol Exp Ther 283:1214\u20131222","journal-title":"J Pharmacol Exp Ther"},{"key":"465_CR70","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0165-6147(97)89800-8","volume":"18","author":"R Spanagel","year":"1997","unstructured":"Spanagel R, Zieglgansberger W (1997) Anti-craving compounds for alcohol: new pharmacological tools to study addictive processes. Trends Pharmacol Sci 18:54\u201359","journal-title":"Trends Pharmacol Sci"},{"key":"465_CR71","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-2999(94)90023-X","volume":"262","author":"R Spanagel","year":"1994","unstructured":"Spanagel R, Eilbacher B, Wilke R (1994) Memantine-induced dopamine release in the prefrontal cortex and striatum of the rat\u2014a pharmacokinetic microdialysis study. Eur J Pharmacol 262:21\u201326","journal-title":"Eur J Pharmacol"},{"key":"465_CR72","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF02252961","volume":"9","author":"MS Starr","year":"1995","unstructured":"Starr MS, Starr BS (1995) Locomotor effects of amantadine in the mouse are not those of a typical glutamate antagonist. J Neural Transm Parkinson\u2019s Dis Dement Sect 9:31\u201343","journal-title":"J Neural Transm Parkinson\u2019s Dis Dement Sect"},{"key":"465_CR73","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF01271551","volume":"101","author":"A Svensson","year":"1995","unstructured":"Svensson A, Carlsson ML, Carlsson A (1995) Crucial role of the accumbens nucleus in the neurotransmitter interactions regulating motor control in mice. J Neural Transm Gen Sect 101:127\u2013148","journal-title":"J Neural Transm Gen Sect"},{"key":"465_CR74","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0741-8329(86)90054-6","volume":"3","author":"M Tang","year":"1986","unstructured":"Tang M, Falk JL (1986) Alcohol polydipsic choice: effects of alternative fluid polydipsic history. Alcohol 3:361\u2013365","journal-title":"Alcohol"},{"key":"465_CR75","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF00427328","volume":"85","author":"A Tazi","year":"1986","unstructured":"Tazi A, Dantzer R, Mormede P, LeMoal M (1986) Effects of naloxone, \u03b2-endorphin and ACTH on acquisition of schedule-induced polydipsia. Psychopharmacology 85:87\u201391","journal-title":"Psychopharmacology"},{"key":"465_CR76","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/j.1530-0277.2001.tb02327.x","volume":"25","author":"G Wand","year":"2001","unstructured":"Wand G, McCaul ME, Gotjen D, Reynolds J, Lee S (2001) Confirmation that offspring from families with alcohol-dependent individuals have greater hypothalamic-pituitary-adrenal axis activation induced by naloxone compared with offspring without a family history of alcohol dependence. Alcohol Clin Exp Res 25:1134\u20131139","journal-title":"Alcohol Clin Exp Res"},{"key":"465_CR77","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0091-3057(02)00780-3","volume":"73","author":"MJ Wayner","year":"2002","unstructured":"Wayner MJ (2002) Craving for alcohol in the rat: adjunctive behavior and the lateral hypothalamus. Pharmacol Biochem Behav 73:27\u201343","journal-title":"Pharmacol Biochem Behav"},{"key":"465_CR78","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0926-6917(95)00028-3","volume":"293","author":"GL Wenk","year":"1995","unstructured":"Wenk GL, Danysz W, Mobley SL (1995) MK-801, memantine and amantadine show neuroprotective activity in the nucleus basalis magnocellularis. Eur J Pharmacol 293:267\u2013270","journal-title":"Eur J Pharmacol"},{"key":"465_CR79","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0031-9384(92)90334-X","volume":"52","author":"SL Williams","year":"1992","unstructured":"Williams SL, Tang M, Falk JL (1992) Prior exposure to a running wheel and scheduled food attenuates polydipsia acquisition. Physiol Behav 52:481\u2013483","journal-title":"Physiol Behav"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-006-0465-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-006-0465-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-006-0465-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T16:26:12Z","timestamp":1736439972000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-006-0465-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,12]]},"references-count":79,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["465"],"URL":"https:\/\/doi.org\/10.1007\/s00213-006-0465-5","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,12]]}}}