{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:44:35Z","timestamp":1789764275617,"version":"4.0.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1007\/s00213-008-1068-0","type":"journal-article","created":{"date-parts":[[2008,5,31]],"date-time":"2008-05-31T00:10:34Z","timestamp":1212192634000},"page":"29-36","source":"Crossref","is-referenced-by-count":36,"title":["The effects of modafinil on mood and cognition in Huntington\u2019s disease"],"prefix":"10.1007","volume":"199","author":[{"given":"Andrew D.","family":"Blackwell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole S.","family":"Paterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor W.","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Sahakian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,6,1]]},"reference":[{"key":"1068_CR1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.ne.09.030186.002041","volume":"9","author":"GE Alexander","year":"1986","unstructured":"Alexander GE, DeLong MR, Strick PL (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9:357\u2013381","journal-title":"Annu Rev Neurosci"},{"key":"1068_CR2","first-page":"197","volume":"96","author":"KE Anderson","year":"2005","unstructured":"Anderson KE, Marshall FJ (2005) Behavioral symptoms associated with Huntington\u2019s disease. Adv Neurol 96:197\u2013208 Review","journal-title":"Adv Neurol"},{"issue":"12","key":"1068_CR3","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/S0006-3223(03)00609-7","volume":"54","author":"AR Aron","year":"2003","unstructured":"Aron AR, Dowson JH, Sahakian BJ, Robbins TW (2003) Methylphenidate improves response inhibition in adults with attention-deficit\/hyperactivity disorder. Biol Psychiatry 54(12):1465\u20131468","journal-title":"Biol Psychiatry"},{"key":"1068_CR4","first-page":"117","volume-title":"Handbook of neuropsychology, vol. 7","author":"A Bechara","year":"2002","unstructured":"Bechara A, Tranel D, Damasio AR (2002) The somatic marker hypothesis and decision-making. In: Grafman J (ed) Handbook of neuropsychology, vol. 7. 2nd edn. Elsevier Science BV, Amsterdam, pp 117\u2013143","edition":"2"},{"key":"1068_CR5","volume-title":"Beck depression inventory manual","author":"AT Beck","year":"1987","unstructured":"Beck AT, Steer RA (1987) Beck depression inventory manual. Psychological Corporation, San Antonio, TX"},{"key":"1068_CR6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.2044-8341.1974.tb02285.x","volume":"47","author":"A Bond","year":"1974","unstructured":"Bond A, Lader M (1974) The use of analogue scales in rating subjective feelings. Br J Med Psychol 47:211\u2013218","journal-title":"Br J Med Psychol"},{"issue":"4","key":"1068_CR7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0092-8674(00)81973-X","volume":"98","author":"RM Chemelli","year":"1999","unstructured":"Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB, Yanagisawa M (1999) Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98(4):437\u2013451","journal-title":"Cell"},{"issue":"2","key":"1068_CR8","first-page":"215","volume":"47","author":"A Ciarmiello","year":"2006","unstructured":"Ciarmiello A, Cannella M, Lastoria S, Simonelli M, Frati L, Rubinsztein DC, Squitieri F (2006) Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington\u2019s disease. J Nucl Med 47(2):215\u2013222","journal-title":"J Nucl Med"},{"issue":"4","key":"1068_CR9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00213-002-1080-8","volume":"161","author":"V Deroche-Gamonet","year":"2002","unstructured":"Deroche-Gamonet V, Darnaudery M, Bruins-Slot L, Piat F, Le Moal M, Piazza PV (2002) Study of the addictive potential of modafinil in na\u00efve and cocaine-experienced rats. Psychopharmacology 161(4):387\u2013395","journal-title":"Psychopharmacology"},{"issue":"11\u201312","key":"1068_CR10","first-page":"1329","volume":"27","author":"JJ Downes","year":"1987","unstructured":"Downes JJ, Roberts AC, Sahakian BJ, Evenden JL, Morris RG, Robbins TW (1987) Impaired extra-dimensional shift performance in medicated and unmedicated Parkinson\u2019s disease: evidence for a specific attentional dysfunction. Neuropsychologia 27(11\u201312):1329\u20131343","journal-title":"Neuropsychologia"},{"issue":"2","key":"1068_CR11","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s002130050284","volume":"131","author":"R Elliott","year":"1997","unstructured":"Elliott R, Sahakian BJ, Matthews K, Bannerjea A, Rimmer J, Robbins TW (1997) Effects of methylphenidate on spatial working memory and planning in healthy young adults. Psychopharmacology 131(2):196\u2013206","journal-title":"Psychopharmacology"},{"issue":"2","key":"1068_CR12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s002130050926","volume":"143","author":"J Evenden","year":"1999","unstructured":"Evenden J (1999) The pharmacology of impulsive behaviour in rats V: the effects of drugs on responding under a discrimination task using unreliable visual stimuli. Psychopharmacology 143(2):111\u2013122","journal-title":"Psychopharmacology"},{"key":"1068_CR13","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S0006-3223(97)00353-3","volume":"42","author":"L Ferraro","year":"1997","unstructured":"Ferraro L, Antonelli T, O\u2019Connor WT, Tanganelli S, Rambert FA, Fuxe K (1997) Modafinil: an antinarcoleptic drug with a different neurochemical profile to damphetamine and dopamine uptake blockers. Biol Psychiatry 42:1181\u20131183","journal-title":"Biol Psychiatry"},{"issue":"12","key":"1068_CR14","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1212\/01.WNL.0000098878.47789.BD","volume":"61","author":"AK Ho","year":"2003","unstructured":"Ho AK, Sahakian BJ, Brown RG, Barker RA, Hodges JR, Ane MN, Snowden J, Thompson J, Esmonde T, Gentry R, Moore JW, Bodner T, NEST-HD Consortium (2003) Profile of cognitive progression in early Huntington\u2019s disease. Neurology 61(12):1702\u20131706","journal-title":"Neurology"},{"key":"1068_CR15","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/mds.870110204","volume":"11","author":"Huntington Study Group","year":"1996","unstructured":"Huntington Study Group (1996) The unified Huntington\u2019s disease rating scale: reliability and consistency. Mov Disord 11:136\u2013142","journal-title":"Mov Disord"},{"issue":"2","key":"1068_CR16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0304-3940(03)00006-5","volume":"339","author":"T Ishizuka","year":"2003","unstructured":"Ishizuka T, Sakamoto Y, Sakurai T, Yamatodani A (2003) Modafinil increases histamine release in the anterior hypothalamus of rats. Neurosci Lett 339(2):143\u2013146","journal-title":"Neurosci Lett"},{"issue":"Pt 7","key":"1068_CR17","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/brain\/121.7.1329","volume":"121","author":"AD Lawrence","year":"1998","unstructured":"Lawrence AD, Hodges JR, Rosser AE, Kershaw A, ffrench-Constant C, Rubinsztein DC, Robbins TW, Sahakian BJ (1998a) Evidence for specific cognitive deficits in preclinical Huntington\u2019s disease. Brain 121(Pt 7):1329\u20131341","journal-title":"Brain"},{"issue":"Pt7","key":"1068_CR18","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/brain\/121.7.1343","volume":"121","author":"AD Lawrence","year":"1998","unstructured":"Lawrence AD, Weeks RA, Brooks DJ, Andrews TC, Watkins LH, Harding AE, Robbins TW, Sahakian BJ (1998b) The relationship between striatal dopamine receptor binding and cognitive performance in Huntington\u2019s disease. Brain 121(Pt7):1343\u20131355","journal-title":"Brain"},{"key":"1068_CR19","first-page":"189","volume-title":"Inhibitory processes in attention, memory and language","author":"GD Logan","year":"1994","unstructured":"Logan GD (1994) On the ability to inhibit thought and action. In: Dagenbach D, Carr TH (eds) Inhibitory processes in attention, memory and language. Academic, San Diego, pp 189\u2013239"},{"issue":"4","key":"1068_CR20","first-page":"303","volume":"1","author":"RS Marin","year":"1996","unstructured":"Marin RS (1996) Apathy, concept, syndrome, neural mechanisms and treatment. Clinical Neuropsychiatry 1(4):303\u2013314","journal-title":"Clinical Neuropsychiatry"},{"issue":"2","key":"1068_CR21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0165-1781(91)90040-V","volume":"38","author":"RS Marin","year":"1991","unstructured":"Marin RS, Biedrzycki RC, Firinciogullari S (1991) Reliability and validity of the apathy evaluation scale. Psychiatry Res 38(2):143\u2013162","journal-title":"Psychiatry Res"},{"key":"1068_CR22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s002130051102","volume":"146","author":"MA Mehta","year":"1999","unstructured":"Mehta MA, Sahakian BJ, McKenna PJ, Robbins TW (1999) Systemic sulpiride in young adult volunteers simulates the profile of cognitive deficits in Parkinson\u2019s disease. Psychopharmacology (Berl) 146:162\u2013174","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"1068_CR23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1523\/JNEUROSCI.3842-04.2005","volume":"25","author":"AJ Morton","year":"2005","unstructured":"Morton AJ, Wood NI, Hastings MH, Hurelbrink C, Barker RA, Maywood ES (2005) Disintegration of the sleep\u2013wake cycle and circadian timing in Huntington\u2019s disease. J Neurosci 25(1):157\u2013163","journal-title":"J Neurosci"},{"key":"1068_CR24","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1017\/S0033291799001233","volume":"29","author":"FC Murphy","year":"1999","unstructured":"Murphy FC, Sahakian BJ, Rubinsztein JS, Michael A, Rogers RD, Robbins TW, Paykel ES (1999) Emotional bias and inhibitory control processes in mania and depression. Psychol Med 29:1307\u20131321","journal-title":"Psychol Med"},{"key":"1068_CR25","volume-title":"National adult reading test manual","author":"H Nelson","year":"1982","unstructured":"Nelson H (1982) National adult reading test manual. Windsor NFER-Nelson, UK"},{"key":"1068_CR26","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/0028-3932(90)90137-D","volume":"28","author":"AM Owen","year":"1990","unstructured":"Owen AM, Downes JJ, Sahakian BJ, Polkey CE, Robbins TW (1990) Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologia 28:1021\u20131034","journal-title":"Neuropsychologia"},{"key":"1068_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0028-3932(94)00098-A","volume":"33","author":"AM Owen","year":"1995","unstructured":"Owen AM, Sahakian BJ, Semple J, Polkey CE, Robbins TW (1995) Visuo-spatial short term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man. Neuropsychologia 33:1\u201324","journal-title":"Neuropsychologia"},{"issue":"pt5","key":"1068_CR28","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/brain\/awg119","volume":"126","author":"N Pavese","year":"2003","unstructured":"Pavese N, Andrews TC, Brooks DH, Ho AK, Rosser AE, Barker RA, Robbins TW, Sahakian BJ, Dunnett SB, Piccini P (2003) Progressive striatal and cortical dopamine receptor dysfunction in Huntington\u2019s disease: a PET study. Brain 126(pt5):1127\u20131135","journal-title":"Brain"},{"issue":"1","key":"1068_CR29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/hmg\/ddi004","volume":"14","author":"A Petersen","year":"2005","unstructured":"Petersen A, Gil J, Maat-Schieman ML, Bjorkqvist M, Tanila H, Araujo IM, Smith R, Popovic N, Wierup N, Norlen P, Li JY, Roos RA, Sundler F, Mulder H, Brundin P (2005) Orexin loss in Huntington\u2019s disease. Hum Mol Genet 14(1):39\u201347","journal-title":"Hum Mol Genet"},{"issue":"9","key":"1068_CR30","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/mds.20979","volume":"21","author":"HD Rosas","year":"2006","unstructured":"Rosas HD, Tuch DS, Hevelone ND, Zaleta AK, Vangel M, Hersch SM, Salat DH (2006) Diffusion tensor imaging in presymptomatic and early Huntington\u2019s disease: selective white matter pathology and its relationship to clinical measures. Mov Disord 21(9):1317\u20131325","journal-title":"Mov Disord"},{"issue":"22","key":"1068_CR31","doi-asserted-by":"crossref","first-page":"8620","DOI":"10.1523\/JNEUROSCI.20-22-08620.2000","volume":"20","author":"TE Scammel","year":"2000","unstructured":"Scammel TE, Estabrooke IV, McCarthy MT, Chemelli RM, Yanagisawa M, Miller MS, Saper CB (2000) Hypothalamic arousal regions are activated during modafinil-induced wakefulness. J Neurosci 20(22):8620\u20138628","journal-title":"J Neurosci"},{"issue":"4","key":"1068_CR32","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1089\/cap.2000.10.311","volume":"10","author":"FB Taylor","year":"2000","unstructured":"Taylor FB, Russo J (2000) Efficacy of modafinil compared to dextoamphetamine for the treatment of attention deficit hyperactivity disorder in adults. J Child Adolesc Psychopharmacol 10(4):311\u2013320 Winter","journal-title":"J Child Adolesc Psychopharmacol"},{"issue":"3","key":"1068_CR33","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s00213-002-1250-8","volume":"165","author":"DC Turner","year":"2003","unstructured":"Turner DC, Robbins TW, Clark L, Aron AR, Dowson J, Sahakian BJ (2003a) Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology 165(3):260\u2013269","journal-title":"Psychopharmacology"},{"issue":"4","key":"1068_CR34","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00213-003-1457-3","volume":"168","author":"DC Turner","year":"2003","unstructured":"Turner DC, Robbins TW, Clark L, Aron AR, Dowson J, Sahakian BJ (2003b) Relative lack of cognitive effects of methylphenidate in elderly male volunteers. Psychopharmacology (Berl) 168(4):455\u2013464","journal-title":"Psychopharmacology (Berl)"},{"issue":"10","key":"1068_CR35","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.biopsych.2004.02.008","volume":"55","author":"DC Turner","year":"2004","unstructured":"Turner DC, Clark L, Dowson J, Robbins TW, Sahakian BJ (2004a) Modafinil improves cognition and response inhibition in adult attention-deficit-hyperactivity disorder. Biol Psychiatry 55(10):1031\u20131040","journal-title":"Biol Psychiatry"},{"issue":"7","key":"1068_CR36","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/sj.npp.1300457","volume":"29","author":"DC Turner","year":"2004","unstructured":"Turner DC, Clark L, Pomarol-Clotet E, McKenna P, Robbins TW, Sahakian BJ (2004b) Modafinil improves cognition and attentional set shifting in patients with chronic schizophrenia. Neuropsychopharmacology 29(7):1363\u20131373","journal-title":"Neuropsychopharmacology"},{"key":"1068_CR37","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1037\/0022-3514.54.6.1063","volume":"54","author":"D Watson","year":"1988","unstructured":"Watson D, Clark LA, Tellegen A (1988) Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol 54:1063\u20131070","journal-title":"J Pers Soc Psychol"},{"key":"1068_CR38","volume-title":"Wechsler adult intelligence scale\u2014revised","author":"D Wechsler","year":"1981","unstructured":"Wechsler D (1981) Wechsler adult intelligence scale\u2014revised. The Psychological Corporation, New York"},{"key":"1068_CR39","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/arclin\/17.6.547","volume":"17","author":"K Werheid","year":"2002","unstructured":"Werheid K, Hoppe C, Th\u00f6ne A, M\u00fcller U, M\u00fcngersdorf M, Von Cramon DY (2002) The adaptive digit ordering test: clinical application, reliability and validity of a verbal working memory test. Arch Clin Neuropsychol 17:547\u2013565","journal-title":"Arch Clin Neuropsychol"},{"issue":"4","key":"1068_CR40","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.neuroscience.2004.10.005","volume":"130","author":"JT Willie","year":"2005","unstructured":"Willie JT, Renthal W, Chemelli RM, Miller MS, Scammell TE, Yanagisawa M, Sinton CM (2005) Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates. Neuroscience 130(4):983\u2013995","journal-title":"Neuroscience"},{"issue":"4","key":"1068_CR41","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.neuroscience.2005.02.003","volume":"132","author":"JP Wisor","year":"2005","unstructured":"Wisor JP, Eriksson KS (2005) Dopaminergic\u2013adrenergic interactions in the wake promoting mechanism of modafinil. Neuroscience 132(4):1027\u20131034","journal-title":"Neuroscience"},{"issue":"5","key":"1068_CR42","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1523\/JNEUROSCI.21-05-01787.2001","volume":"21","author":"JP Wisor","year":"2001","unstructured":"Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM (2001) Dopaninergic role in stimulant-induced wakefulness. J Neurosci 21(5):1787\u20131794","journal-title":"J Neurosci"},{"key":"1068_CR43","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/j.1552-4604.1998.tb04425.x","volume":"38","author":"YN Wong","year":"1998","unstructured":"Wong YN, King SP, Laughton WB, McCormick GC, Grebow PE (1998) Single-dose pharmacokinetics of modafinil and methylphenidate given alone or in combination in healthy male volunteers. J Clin Pharmacol 38:276\u2013282","journal-title":"J Clin Pharmacol"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-008-1068-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-008-1068-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-008-1068-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T16:06:35Z","timestamp":1558627595000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-008-1068-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["1068"],"URL":"https:\/\/doi.org\/10.1007\/s00213-008-1068-0","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,1]]}}}