{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:42:51Z","timestamp":1791142971160,"version":"4.1.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T00:00:00Z","timestamp":1219968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1007\/s00213-008-1306-5","type":"journal-article","created":{"date-parts":[[2008,8,28]],"date-time":"2008-08-28T10:17:39Z","timestamp":1219918659000},"page":"443-458","source":"Crossref","is-referenced-by-count":107,"title":["Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation"],"prefix":"10.1007","volume":"201","author":[{"given":"Baoman","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiquen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Nu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Hertz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,8,29]]},"reference":[{"key":"1306_CR1","doi-asserted-by":"crossref","first-page":"441S","DOI":"10.1002\/j.1550-8528.1995.tb00211.x","volume":"4","author":"M Baez","year":"1995","unstructured":"Baez M, Kursar JD, Helton LA, Wainscott DB, Nelson DL (1995) Molecular biology of serotonin receptors. Obes Res 4:441S\u2013447S","journal-title":"Obes Res"},{"key":"1306_CR2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00429-004-0380-7","volume":"208","author":"N Bhasin","year":"2004","unstructured":"Bhasin N, LaMantia AS, Lauder JM (2004) Opposing regulation of cell proliferation by retinoic acid and the serotonin2B receptor in the mouse frontonasal mass. Anat Embryol (Berl) 208:135\u2013143","journal-title":"Anat Embryol (Berl)"},{"key":"1306_CR3","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0893-133X(00)00116-0","volume":"23","author":"NR Bolo","year":"2000","unstructured":"Bolo NR, Hod\u00e9 Y, N\u00e9d\u00e9lec JF, Lain\u00e9 E, Wagner G, Macher JP (2000) Brain pharmacokinetics and tissue distribution in vivo of fluvoxamine and fluoxetine by fluorine magnetic resonance spectroscopy. Neuropsychopharmacol 23:428\u2013438","journal-title":"Neuropsychopharmacol"},{"key":"1306_CR4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ejphar.2005.03.013","volume":"513","author":"P Bonaventure","year":"2005","unstructured":"Bonaventure P, Nepomuceno D, Miller K, Chen J, Kuei C, Kamme F, Tran DT, Lovenberg TW, Liu C (2005) Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog. Eur J Pharmacol 513:181\u2013192","journal-title":"Eur J Pharmacol"},{"key":"1306_CR5","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1476-5381.1995.tb14977.x","volume":"115","author":"DW Bonhaus","year":"1995","unstructured":"Bonhaus DW, Bach C, DeSouza A, Salazar FH, Matsuoka BD, Zuppan P, Chan HW, Eglen RM (1995) The pharmacology and distribution of human 5-hydroxytryptamine2B (5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. Br J Pharmacol 115:622\u2013628","journal-title":"Br J Pharmacol"},{"key":"1306_CR6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"1306_CR7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0361-9230(95)00082-P","volume":"38","author":"Y Chen","year":"1995","unstructured":"Chen Y, Peng L, Zhang X, Stolzenburg JU, Hertz L (1995) Further evidence that fluoxetine interacts with a 5-HT2C receptor in glial cells. Brain Res Bull 38:153\u2013159","journal-title":"Brain Res Bull"},{"key":"1306_CR8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0014-5793(96)00695-3","volume":"391","author":"DS Choi","year":"1996","unstructured":"Choi DS, Maroteaux L (1996) Immunohistochemical localisation of the serotonin 5-HT2B receptor in mouse gut, cardiovascular system, and brain. FEBS Lett 391:45\u201351","journal-title":"FEBS Lett"},{"key":"1306_CR9","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1242\/dev.124.9.1745","volume":"124","author":"DS Choi","year":"1997","unstructured":"Choi DS, Ward SJ, Messaddeq N, Launay JM, Maroteaux L (1997) 5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardiac cells. Development 124:1745\u20131755","journal-title":"Development"},{"key":"1306_CR10","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/j.1471-4159.2006.04420.x","volume":"101","author":"DS Cowen","year":"2007","unstructured":"Cowen DS (2007) Serotonin and neuronal growth factors - a convergence of signaling pathways. J. Neurochem 101:1161\u20131171","journal-title":"J. Neurochem"},{"key":"1306_CR11","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/jnr.490350304","volume":"35","author":"DC Deecher","year":"1993","unstructured":"Deecher DC, Wilcox BD, Dave V, Rossman PA, Kimelberg HK (1993) Detection of 5-hydroxytryptamine2 receptors by radioligand binding, northern blot analysis, and Ca2+ responses in rat primary astrocyte cultures. J Neurosci Res 35:246\u2013256","journal-title":"J Neurosci Res"},{"key":"1306_CR12","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0028-3908(97)00042-7","volume":"6","author":"MS Duxon","year":"1997","unstructured":"Duxon MS, Kennett GA, Lightowler S, Blackburn TP, Fone KC (1997) Activation of 5-HT2B receptors in the medial amygdala causes anxiolysis in the social interaction test in the rat. Neuropharmacol 6:601\u2013608","journal-title":"Neuropharmacol"},{"key":"1306_CR13","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1128\/MCB.19.4.2594","volume":"19","author":"A Elkeles","year":"1999","unstructured":"Elkeles A, Juven-Gershon T, Israeli D, Wilder S, Zalcenstein A, Oren M (1999) The c-fos proto-oncogene is a target for transactivation by the p53 tumor suppressor. Mol Cell Biol 19:2594\u20132600","journal-title":"Mol Cell Biol"},{"key":"1306_CR14","doi-asserted-by":"crossref","first-page":"18623","DOI":"10.1074\/jbc.273.29.18623","volume":"273","author":"MF Favata","year":"1998","unstructured":"Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, Trzaskos JM (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273:18623\u201318632","journal-title":"J Biol Chem"},{"key":"1306_CR15","doi-asserted-by":"crossref","first-page":"26107","DOI":"10.1016\/S0021-9258(19)74287-2","volume":"268","author":"PB Gordon","year":"1993","unstructured":"Gordon PB, Holen I, Fosse M, R\u00f8tnes JS, Seglen PO (1993) Dependence of hepatocytic autophagy on intracellularly sequestered calcium. J Biol Chem 268:26107\u201326112","journal-title":"J Biol Chem"},{"key":"1306_CR16","doi-asserted-by":"crossref","first-page":"7152","DOI":"10.1021\/bi00146a017","volume":"31","author":"D Grobelny","year":"1992","unstructured":"Grobelny D, Poncz L, Galardy E (1992) Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochem 31:7152\u20137154","journal-title":"Biochem"},{"key":"1306_CR17","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1176\/appi.ajp.157.9.1506","volume":"157","author":"ME Henry","year":"2000","unstructured":"Henry ME, Moore CM, Kaufman MJ, Michelson D, Schmidt ME, Stoddard E, Vuckevic AJ, Berreira PJ, Cohen BM, Renshaw PF (2000) Brain kinetics of paroxetine and fluoxetine on the third day of placebo substitution: a fluorine MRS study. Am J Psychiatry 157:1506\u20131508","journal-title":"Am J Psychiatry"},{"key":"1306_CR18","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1038\/sj.npp.1300749","volume":"30","author":"ME Henry","year":"2005","unstructured":"Henry ME, Schmidt ME, Hennen J, Villafuerte RA, Butman ML, Tran P, Kerner LT, Cohen B, Renshaw PF (2005) A comparison of brain and serum pharmacokinetics of R-fluoxetine and racemic fluoxetine: a 19-F MRS study. Neuropsychopharmacol 30:1576\u20131583","journal-title":"Neuropsychopharmacol"},{"key":"1306_CR19","first-page":"603","volume-title":"Handbook of Neurochemistry Vol 8,","author":"L Hertz","year":"1985","unstructured":"Hertz L, Juurlink BHJ, Szuchet S (1985) Cell cultures. In: Lajtha A (ed) Handbook of Neurochemistry Vol 8,. 2nd edn. Plenum Press, New York, pp 603\u2013661","edition":"2"},{"key":"1306_CR20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1006\/meth.1998.0686","volume":"16","author":"L Hertz","year":"1998","unstructured":"Hertz L, Peng L, Lai JC (1998) Functional studies in cultured astrocytes. Methods 16:293\u2013310","journal-title":"Methods"},{"key":"1306_CR21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0169-328X(98)00206-X","volume":"61","author":"WD Hirst","year":"1998","unstructured":"Hirst WD, Cheung NY, Rattray M, Price GW, Wilkin GP (1998) Cultured astrocytes express messenger RNA for multiple serotonin receptor subtypes, without functional coupling of 5-HT1 receptor subtypes to adenylyl cyclase. Mol Brain Res 61:90\u201399","journal-title":"Mol Brain Res"},{"key":"1306_CR22","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1124\/jpet.106.116558","volume":"321","author":"K Hisaoka","year":"2007","unstructured":"Hisaoka K, Takebayashi M, Tsuchioka M, Maeda N, Nakata Y, Yamawaki S (2007) Antidepressants increase glial cell line-derived neurotrophic factor production through monoamine-independent activation of protein tyrosine kinase and extracellular signal-regulated kinase in glial cells. J Pharmacol Exp Ther 321:148\u2013157","journal-title":"J Pharmacol Exp Ther"},{"key":"1306_CR23","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1002\/jnr.21455","volume":"85","author":"S Hitoshi","year":"2007","unstructured":"Hitoshi S, Maruta N, Higashi M, Kumar A, Kato N, Ikenaka K (2007) Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress. J Neurosci Res 85:3574\u20133585","journal-title":"J Neurosci Res"},{"key":"1306_CR24","doi-asserted-by":"crossref","first-page":"49795","DOI":"10.1074\/jbc.M404096200","volume":"279","author":"D Inoue","year":"2004","unstructured":"Inoue D, Kido S, Matsumoto T (2004) Transcriptional induction of FosB\/DeltaFosB gene by mechanical stress in osteoblasts. J Biol Chem 279:49795\u201349803","journal-title":"J Biol Chem"},{"key":"1306_CR25","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1161\/01.CIR.0000139856.20505.57","volume":"110","author":"F Jaffre","year":"2004","unstructured":"Jaffre F, Callebert J, Sarre A, Etienne N, Nebigil CG, Launay JM, Maroteaux L, Monassier L (2004) Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts. Circulation 110:969\u2013974","journal-title":"Circulation"},{"key":"1306_CR26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-2999(01)00775-0","volume":"414","author":"JC Jerman","year":"2001","unstructured":"Jerman JC, Brough SJ, Gager T, Wood M, Coldwell MC, Smart D, Middlemiss DN (2001) Pharmacological characterisation of human 5-HT2 receptor subtypes. Eur J Pharmacol 414:23\u201330","journal-title":"Eur J Pharmacol"},{"key":"1306_CR27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF00178722","volume":"354","author":"MP Johnson","year":"1996","unstructured":"Johnson MP, Siegel BW, Carr AA (1996) [3H]MDL 100,907: a novel selective 5-HT2A receptor ligand. Naunyn. Schmiedebergs. Arch Pharmacol 354:205\u2013209","journal-title":"Arch Pharmacol"},{"key":"1306_CR28","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0028-3908(97)00038-5","volume":"36","author":"GA Kennett","year":"1997","unstructured":"Kennett GA, Wood MD, Bright F, Trail B, Riley G, Holland V, Avenell KY, Stean T, Upton N, Bromidge S, Forbes IT, Brown AM, Middlemiss DN, Blackburn TP (1997) SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacol 36:609\u2013620","journal-title":"Neuropharmacol"},{"key":"1306_CR29","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0893-133X(02)00377-9","volume":"27","author":"S Koch","year":"2002","unstructured":"Koch S, Perry KW, Nelson DL, Conway RG, Threlkfeld PG, Bymaster FP (2002) R-fluoxetine increases extracellular DA, NE, as well as 5-HT in rat prefrontal cortex and hypothalamus: an in vivo microdialysis and receptor binding study. Neuropsychopharmacol 27:949\u2013959","journal-title":"Neuropsychopharmacol"},{"key":"1306_CR30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/A:1014862808126","volume":"27","author":"EK Kong","year":"2002","unstructured":"Kong EK, Peng L, Chen Y, Yu AC, Hertz L (2002) Up-regulation of 5-HT2B receptor density and receptor-mediated glycogenolysis in mouse astrocytes by long-term fluoxetine administration. Neurochem Res 27:113\u2013120","journal-title":"Neurochem Res"},{"key":"1306_CR31","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0026-895X(25)09676-2","volume":"46","author":"JD Kursar","year":"1994","unstructured":"Kursar JD, Nelson DL, Wainscott DB, Baez M (1994) Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor. Mol Pharmacol 46:227\u2013234","journal-title":"Mol Pharmacol"},{"key":"1306_CR32","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1126\/science.7892601","volume":"267","author":"A Levitzki","year":"1995","unstructured":"Levitzki A, Gazit A (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267:1782\u20131788","journal-title":"Science"},{"key":"1306_CR33","doi-asserted-by":"crossref","unstructured":"Li B, Du T, Li H, Gu L, Zhang H, Huang J, Hertz L, Peng L (2008) Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons. Br J Pharmacol 154:191\u2013203","DOI":"10.1038\/bjp.2008.58"},{"key":"1306_CR34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cardiores.2006.08.003","volume":"72","author":"YJ Liang","year":"2006","unstructured":"Liang YJ, Lai LP, Wang BW, Juang SJ, Chang CM, Leu JG, Shyu KG (2006) Mechanical stress enhances serotonin 2B receptor modulating brain natriuretic peptide through nuclear factor-\u03baB in cardiomyocytes. Cardiovascular Res 72:303\u2013312","journal-title":"Cardiovascular Res"},{"key":"1306_CR35","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1093\/carcin\/21.12.2211","volume":"21","author":"AE Marjou","year":"2000","unstructured":"Marjou AE, Delouv\u00e9e A, Thiery JP, Radvanyi F (2000) Involvement of epidermal growth factor receptor in chemically induced mouse bladder tumour progression. Carcinogenesis 21:2211\u20132218","journal-title":"Carcinogenesis"},{"key":"1306_CR36","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1600-0447.1989.tb10307.x","volume":"79","author":"B M\u00e5rtensson","year":"1989","unstructured":"M\u00e5rtensson B, Nyberg S, Toresson G, Brodin E, Bertilsson L (1989) Fluoxetine treatment of depression. Clinical effects, drug concentrations and monoamine metabolites and N-terminally extended substance P in cerebrospinal fluid. Acta Psychiatr Scand 79:586\u2013596","journal-title":"Acta Psychiatr Scand"},{"key":"1306_CR37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-0186(91)90113-R","volume":"19","author":"E Meier","year":"1991","unstructured":"Meier E, Hertz L, Schousboe A (1991) Neurotransmitters as developmental signals. Neurochem Int 19:1\u201315","journal-title":"Neurochem Int"},{"key":"1306_CR38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1385\/JMN:24:2:207","volume":"4","author":"G Mercier","year":"2004","unstructured":"Mercier G, Lennon AM, Renouf B, Dessouroux A, Ramauge M, Courtin F, Pierre M (2004) MAP kinase activation by fluoxetine and its relation to gene expression in cultured rat astrocytes. J Mol Neurosci 4:207\u2013216","journal-title":"J Mol Neurosci"},{"key":"1306_CR39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0169-328X(96)00058-7","volume":"41","author":"A Merzak","year":"1996","unstructured":"Merzak A, Koochekpour S, Fillion MP, Fillion G, Pilkington GJ (1996) Expression of serotonin receptors in human fetal astrocytes and glioma cell lines: a possible role in glioma cell proliferation and migration. Mol Brain Res 41:1\u20137","journal-title":"Mol Brain Res"},{"key":"1306_CR40","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1176\/appi.ajp.161.5.826","volume":"161","author":"JH Meyer","year":"2004","unstructured":"Meyer JH, Wilson AA, Sagrati S, Hussey D, Carella A, Potter WZ, Ginovart N, Spencer EP, Cheok A, Houle S (2004) Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study. Am J Psychiatry 161:826\u2013835","journal-title":"Am J Psychiatry"},{"key":"1306_CR41","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S1050-1738(01)00135-9","volume":"11","author":"CG Nebigil","year":"2001","unstructured":"Nebigil CG, Maroteaux L (2001) A novel role for serotonin in heart. Trends Cardiovasc Med 11:329\u2013335","journal-title":"Trends Cardiovasc Med"},{"key":"1306_CR42","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1073\/pnas.050282397","volume":"97","author":"CG Nebigil","year":"2000","unstructured":"Nebigil CG, Launay JM, Hickel P, Tournois C, Maroteaux L (2000) 5-Hydroxytryptamine 2B receptor regulates cell-cycle progression: cross-talk with tyrosine kinase pathways. Proc Natl Acad Sci U S A 97:2591\u20132596","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1306_CR43","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1073\/pnas.94.5.2036","volume":"94","author":"YG Ni","year":"1997","unstructured":"Ni YG, Miledi R (1997) Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac). Proc Natl Acad Sci USA 94:2036\u20132040","journal-title":"Proc Natl Acad Sci USA"},{"key":"1306_CR44","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/BF02246453","volume":"126","author":"EP P\u00e4lvim\u00e4ki","year":"1996","unstructured":"P\u00e4lvim\u00e4ki EP, Roth BL, Majasuo H, Leaks A, Kuoppam\u00e4ki M, Syv\u00e4lahti E, Hietala J (1996) Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2C receptor. Psychopharmacol 126:234\u2013240","journal-title":"Psychopharmacol"},{"key":"1306_CR45","first-page":"503","volume-title":"Non-neuronal cells of the nervous system: function and dysfunction","author":"L Peng","year":"2004","unstructured":"Peng L (2004) Transactivation in astrocytes as a novel mechanism of neuroprotection. In: Hertz L (ed) Non-neuronal cells of the nervous system: function and dysfunction. Elsevier, Amsterdam, pp 503\u2013518"},{"key":"1306_CR46","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1038\/sj.onc.1204184","volume":"20","author":"KL Pierce","year":"2001","unstructured":"Pierce KL, Luttrell LM, Lefkowitz RJ (2001) New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene 20:1532\u20131539","journal-title":"Oncogene"},{"key":"1306_CR47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/sj.bjp.0702751","volume":"128","author":"RH Porter","year":"1999","unstructured":"Porter RH, Benwell KR, Lamb H, Malcolm CS, Allen NH, Revell DF, Adams DR, Sheardown MJ (1999) Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells. Br J Pharmacol 128:13\u201320","journal-title":"Br J Pharmacol"},{"key":"1306_CR48","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1677\/erc.0.0080011","volume":"8","author":"N Prenzel","year":"2001","unstructured":"Prenzel N, Fischer OM, Streit S, Hart S, Ullrich A (2001) The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocr Relat Cancer 8:11\u201331","journal-title":"Endocr Relat Cancer"},{"key":"1306_CR49","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1056\/NEJMp068265","volume":"356","author":"BL Roth","year":"2007","unstructured":"Roth BL (2007) Drugs and valvular heart disease. N Engl Med 356:6\u20139","journal-title":"N Engl Med"},{"key":"1306_CR50","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0163-7258(98)00019-9","volume":"79","author":"BL Roth","year":"1998","unstructured":"Roth BL, Willins DL, Kristiansen K, Kroeze WK (1998) 5-Hydroxytryptamine2-family receptors (5-hydroxytryptamine2A, 5-hydroxytryptamine2B, 5-hydroxytryptamine2C): where structure meets function. Pharmacol Ther 79:231\u2013257","journal-title":"Pharmacol Ther"},{"key":"1306_CR51","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1161\/01.CIR.102.23.2836","volume":"102","author":"RB Rothman","year":"2000","unstructured":"Rothman RB, Baumann MH, Savage JE, Rauser L, McBride A, Hufeisen SJ, Roth BL (2000) Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation 102:2836\u20132841","journal-title":"Circulation"},{"key":"1306_CR52","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1023\/A:1006986824213","volume":"19","author":"C S\u00e1nchez","year":"1999","unstructured":"S\u00e1nchez C, Hyttel J (1999) Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding. Cell Mol Neurobiol 19:467\u2013489","journal-title":"Cell Mol Neurobiol"},{"key":"1306_CR53","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0197-0186(99)00134-5","volume":"36","author":"N Sand\u00e9n","year":"2000","unstructured":"Sand\u00e9n N, Thorlin T, Blomstrand F, Persson PA, Hansson E (2000) 5-Hydroxytryptamine2B receptors stimulate Ca2+ increases in cultured astrocytes from three different brain regions. Neurochem Int 36:427\u2013434","journal-title":"Neurochem Int"},{"key":"1306_CR54","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0014-2999(92)90819-P","volume":"223","author":"CJ Schmidt","year":"1992","unstructured":"Schmidt CJ, Fadayel GM, Sullivan CK, Taylor VL (1992) 5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue,3,4-methylenedioxymethamphetamine. Eur J Pharmacol 223:65\u201374","journal-title":"Eur J Pharmacol"},{"key":"1306_CR55","doi-asserted-by":"crossref","first-page":"15771","DOI":"10.1016\/S0021-9258(18)98476-0","volume":"266","author":"D Toullec","year":"1991","unstructured":"Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F et al (1991) The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266:15771\u201315781","journal-title":"J Biol Chem"},{"key":"1306_CR56","first-page":"43","volume":"5","author":"DT Wong","year":"1991","unstructured":"Wong DT, Threlkeld PG, Robertson DW (1991) Affinities of fluoxetine, its enantiomers, and other inhibitors of serotonin uptake for subtypes of serotonin receptors. Neuropsychopharmacol 5:43\u201347","journal-title":"Neuropsychopharmacol"},{"issue":"suppl","key":"1306_CR57","first-page":"102P","volume":"110","author":"MD Wood","year":"1993","unstructured":"Wood MD, Glen A, Blackburn TP, Lee JA, Sutiphong JA, Kumar C, Carey J, Robinson J (1993) (\u2212)-Fluoxetine has high affinity for the cloned rat and human 5-HT1C receptor and the human 5-HT2 receptor. Br J Pharmacol 110(suppl):102P","journal-title":"Br J Pharmacol"},{"key":"1306_CR58","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.neuropharm.2006.10.014","volume":"52","author":"A Zazpe","year":"2007","unstructured":"Zazpe A, Artaiz I, Labeaga L, Lucero ML, Orjales A (2007) Reversal of learned helplessness by selective serotonin reuptake inhibitors in rats is not dependent on 5-HT availability. Neuropharmacol 52:975\u2013984","journal-title":"Neuropharmacol"},{"key":"1306_CR59","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1097\/00001756-199309000-00006","volume":"4","author":"X Zhang","year":"1993","unstructured":"Zhang X, Peng L, Chen Y, Hertz L (1993) Stimulation of glycogenolysis in astrocytes by fluoxetine, an antidepressant acting like 5-HT. Neuroreport 4:1235\u20131238","journal-title":"Neuroreport"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-008-1306-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-008-1306-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-008-1306-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T13:31:03Z","timestamp":1738330263000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-008-1306-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,29]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["1306"],"URL":"https:\/\/doi.org\/10.1007\/s00213-008-1306-5","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,29]]}}}