{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:43:41Z","timestamp":1792273421696,"version":"4.4.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,10,30]],"date-time":"2008-10-30T00:00:00Z","timestamp":1225324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1007\/s00213-008-1370-x","type":"journal-article","created":{"date-parts":[[2008,10,28]],"date-time":"2008-10-28T22:42:15Z","timestamp":1225233735000},"page":"73-84","source":"Crossref","is-referenced-by-count":92,"title":["Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver"],"prefix":"10.1007","volume":"203","author":[{"given":"Johan","family":"Fern\u00f8","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audun O.","family":"Vik-Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Jassim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarte","family":"H\u00e5vik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjetil","family":"Berge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silje","family":"Skrede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oddrun A.","family":"Gudbrandsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Waage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niclas","family":"Lunder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sverre","family":"M\u00f8rk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf K.","family":"Berge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo A.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidar M.","family":"Steen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,10,30]]},"reference":[{"key":"1370_CR1","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1176\/ajp.156.11.1686","volume":"156","author":"DB Allison","year":"1999","unstructured":"Allison DB, Mentore JL, Heo M, Chandler LP, Cappelleri JC, Infante MC, Weiden PJ (1999) Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 156:1686\u20131696","journal-title":"Am J Psychiatry"},{"key":"1370_CR2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1056\/NEJM199307153290303","volume":"329","author":"JM Alvir","year":"1993","unstructured":"Alvir JM, Lieberman JA, Safferman AZ, Schwimmer JL, Schaaf JA (1993) Clozapine-induced agranulocytosis. Incidence and risk factors in the United States. N Engl J Med 329:162\u2013167","journal-title":"N Engl J Med"},{"key":"1370_CR3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/npp.1993.50","volume":"9","author":"RJ Baldessarini","year":"1993","unstructured":"Baldessarini RJ, Centorrino F, Flood JG, Volpicelli SA, Huston-Lyons D, Cohen BM (1993) Tissue concentrations of clozapine and its metabolites in the rat. Neuropsychopharmacology 9:117\u2013124","journal-title":"Neuropsychopharmacology"},{"issue":"Suppl 23","key":"1370_CR4","first-page":"45","volume":"62","author":"VS Basile","year":"2001","unstructured":"Basile VS, Masellis M, McIntyre RS, Meltzer HY, Lieberman JA, Kennedy JL (2001) Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzle. J Clin Psychiatry 62(Suppl 23):45\u201366","journal-title":"J Clin Psychiatry"},{"key":"1370_CR5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1055\/s-2004-832687","volume":"37","author":"P Baumann","year":"2004","unstructured":"Baumann P, Hiemke C, Ulrich S, Eckermann G, Gaertner I, Gerlach M, Kuss HJ, Laux G, Muller-Oerlinghausen B, Rao ML, Riederer P, Zernig G (2004) The AGNP-TDM expert group consensus guidelines: therapeutic drug monitoring in psychiatry. Pharmacopsychiatry 37:243\u2013265","journal-title":"Pharmacopsychiatry"},{"key":"1370_CR6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(00)80213-5","volume":"89","author":"MS Brown","year":"1997","unstructured":"Brown MS, Goldstein JL (1997) The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89:331\u2013340","journal-title":"Cell"},{"key":"1370_CR7","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00004714-199604000-00010","volume":"16","author":"MJ Byerly","year":"1996","unstructured":"Byerly MJ, DeVane CL (1996) Pharmacokinetics of clozapine and risperidone: a review of recent literature. J Clin Psychopharmacol 16:177\u2013187","journal-title":"J Clin Psychopharmacol"},{"key":"1370_CR8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cmet.2005.04.002","volume":"1","author":"MV Chakravarthy","year":"2005","unstructured":"Chakravarthy MV, Pan Z, Zhu Y, Tordjman K, Schneider JG, Coleman T, Turk J, Semenkovich CF (2005) \u201cNew\u201d hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab 1:309\u2013322","journal-title":"Cell Metab"},{"key":"1370_CR9","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1146\/annurev.biochem.66.1.613","volume":"66","author":"TY Chang","year":"1997","unstructured":"Chang TY, Chang CC, Cheng D (1997) Acyl-coenzyme A:cholesterol acyltransferase. Annu Rev Biochem 66:613\u2013638","journal-title":"Annu Rev Biochem"},{"key":"1370_CR10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0006-3223(99)00029-3","volume":"46","author":"RR Conley","year":"1999","unstructured":"Conley RR, Tamminga CA, Kelly DL, Richardson CM (1999) Treatment-resistant schizophrenic patients respond to clozapine after olanzapine non-response. Biol Psychiatry 46:73\u201377","journal-title":"Biol Psychiatry"},{"key":"1370_CR11","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.2337\/diabetes.53.8.2153","volume":"53","author":"D Eberle","year":"2004","unstructured":"Eberle D, Clement K, Meyre D, Sahbatou M, Vaxillaire M, Le Gall A, Ferre P, Basdevant A, Froguel P, Foufelle F (2004) SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts. Diabetes 53:2153\u20132157","journal-title":"Diabetes"},{"key":"1370_CR12","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/sj.tpj.6500323","volume":"5","author":"J Ferno","year":"2005","unstructured":"Ferno J, Raeder MB, Vik-Mo AO, Skrede S, Glambek M, Tronstad KJ, Breilid H, Lovlie R, Berge RK, Stansberg C, Steen VM (2005) Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action? Pharmacogenomics J 5:298\u2013304","journal-title":"Pharmacogenomics J"},{"key":"1370_CR13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2202-7-69","volume":"7","author":"J Ferno","year":"2006","unstructured":"Ferno J, Skrede S, Vik-Mo AO, Havik B, Steen VM (2006) Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs. BMC Neurosci 7:69","journal-title":"BMC Neurosci"},{"key":"1370_CR14","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000100426","volume":"68","author":"P Ferre","year":"2007","unstructured":"Ferre P, Foufelle F (2007) SREBP-1c transcription factor and lipid homeostasis: clinical perspective. Horm Res 68:72\u201382","journal-title":"Horm Res"},{"key":"1370_CR15","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1056\/NEJMra035458","volume":"349","author":"R Freedman","year":"2003","unstructured":"Freedman R (2003) Schizophrenia. N Engl J Med 349:1738\u20131749","journal-title":"N Engl J Med"},{"key":"1370_CR16","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1176\/ajp.156.8.1270","volume":"156","author":"BD Gaulin","year":"1999","unstructured":"Gaulin BD, Markowitz JS, Caley CF, Nesbitt LA, Dufresne RL (1999) Clozapine-associated elevation in serum triglycerides. Am J Psychiatry 156:1270\u20131272","journal-title":"Am J Psychiatry"},{"key":"1370_CR17","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1093\/ajhp\/53.17.2079","volume":"53","author":"P Ghaeli","year":"1996","unstructured":"Ghaeli P, Dufresne RL (1996) Serum triglyceride levels in patients treated with clozapine. Am J Health Syst Pharm 53:2079\u20132081","journal-title":"Am J Health Syst Pharm"},{"key":"1370_CR18","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1592\/phco.19.13.1099.31586","volume":"19","author":"P Ghaeli","year":"1999","unstructured":"Ghaeli P, Dufresne RL (1999) Elevated serum triglycerides with clozapine resolved with risperidone in four patients. Pharmacotherapy 19:1099\u20131101","journal-title":"Pharmacotherapy"},{"key":"1370_CR19","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1176\/appi.ajp.158.9.1367","volume":"158","author":"DC Goff","year":"2001","unstructured":"Goff DC, Coyle JT (2001) The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. Am J Psychiatry 158:1367\u20131377","journal-title":"Am J Psychiatry"},{"key":"1370_CR20","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1176\/appi.ajp.157.6.975","volume":"157","author":"DC Henderson","year":"2000","unstructured":"Henderson DC, Cagliero E, Gray C, Nasrallah RA, Hayden DL, Schoenfeld DA, Goff DC (2000) Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: a five-year naturalistic study. Am J Psychiatry 157:975\u2013981","journal-title":"Am J Psychiatry"},{"key":"1370_CR21","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1172\/JCI2961","volume":"101","author":"JD Horton","year":"1998","unstructured":"Horton JD, Shimomura I, Brown MS, Hammer RE, Goldstein JL, Shimano H (1998) Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J Clin Invest 101:2331\u20132339","journal-title":"J Clin Invest"},{"key":"1370_CR22","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","volume":"109","author":"JD Horton","year":"2002","unstructured":"Horton JD, Goldstein JL, Brown MS (2002) SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109:1125\u20131131","journal-title":"J Clin Invest"},{"key":"1370_CR23","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1210\/me.2002-0191","volume":"17","author":"T Ide","year":"2003","unstructured":"Ide T, Shimano H, Yoshikawa T, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Nakakuki M, Yatoh S, Iizuka Y, Tomita S, Ohashi K, Takahashi A, Sone H, Gotoda T, Osuga J, Ishibashi S, Yamada N (2003) Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. Mol Endocrinol 17:1255\u20131267","journal-title":"Mol Endocrinol"},{"key":"1370_CR24","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1093\/jn\/135.11.2503","volume":"135","author":"DB Jump","year":"2005","unstructured":"Jump DB, Botolin D, Wang Y, Xu J, Christian B, Demeure O (2005) Fatty acid regulation of hepatic gene transcription. J Nutr 135:2503\u20132506","journal-title":"J Nutr"},{"key":"1370_CR25","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/sj.mp.4002000","volume":"12","author":"R Kaddurah-Daouk","year":"2007","unstructured":"Kaddurah-Daouk R, McEvoy J, Baillie RA, Lee D, Yao JK, Doraiswamy PM, Krishnan KR (2007) Metabolomic mapping of atypical antipsychotic effects in schizophrenia. Mol Psychiatry 12:934\u2013945","journal-title":"Mol Psychiatry"},{"key":"1370_CR26","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1001\/archpsyc.1988.01800330013001","volume":"45","author":"J Kane","year":"1988","unstructured":"Kane J, Honigfeld G, Singer J, Meltzer H (1988) Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch Gen Psychiatry 45:789\u2013796","journal-title":"Arch Gen Psychiatry"},{"key":"1370_CR27","doi-asserted-by":"crossref","first-page":"23908","DOI":"10.1074\/jbc.M403145200","volume":"279","author":"HR Kast-Woelbern","year":"2004","unstructured":"Kast-Woelbern HR, Dana SL, Cesario RM, Sun L, de Grandpre LY, Brooks ME, Osburn DL, Reifel-Miller A, Klausing K, Leibowitz MD (2004) Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome proliferator-activated receptor gamma and sterol regulatory element-binding protein in the regulation of adipogenesis. J Biol Chem 279:23908\u201323915","journal-title":"J Biol Chem"},{"key":"1370_CR28","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1073\/pnas.0611417104","volume":"104","author":"SF Kim","year":"2007","unstructured":"Kim SF, Huang AS, Snowman AM, Teuscher C, Snyder SH (2007) From the Cover: antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase. Proc Natl Acad Sci U S A 104:3456\u20133459","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1370_CR29","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/sj.npp.1300027","volume":"28","author":"WK Kroeze","year":"2003","unstructured":"Kroeze WK, Hufeisen SJ, Popadak BA, Renock SM, Steinberg S, Ernsberger P, Jayathilake K, Meltzer HY, Roth BL (2003) H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28:519\u2013526","journal-title":"Neuropsychopharmacology"},{"key":"1370_CR30","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1176\/ajp.2006.163.7.1273","volume":"163","author":"JS Lamberti","year":"2006","unstructured":"Lamberti JS, Olson D, Crilly JF, Olivares T, Williams GC, Tu X, Tang W, Wiener K, Dvorin S, Dietz MB (2006) Prevalence of the metabolic syndrome among patients receiving clozapine. Am J Psychiatry 163:1273\u20131276","journal-title":"Am J Psychiatry"},{"key":"1370_CR31","doi-asserted-by":"crossref","unstructured":"Le Hellard S, Theisen FM, Haberhausen M, Raeder MB, Ferno J, Gebhardt S, Hinney A, Remschmidt H, Krieg JC, Mehler-Wex C, Nothen MM, Hebebrand J, Steen VM (2008) Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects? Mol Psychiatry. doi: 10.1038\/sj.mp.4002133 (originally published online Jan. 15, 2008).","DOI":"10.1038\/sj.mp.4002133"},{"key":"1370_CR32","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00213-006-0433-0","volume":"187","author":"J Minet-Ringuet","year":"2006","unstructured":"Minet-Ringuet J, Even PC, Lacroix M, Tome D, de Beaurepaire R (2006) A model for antipsychotic-induced obesity in the male rat. Psychopharmacology (Berl) 187:447\u2013454","journal-title":"Psychopharmacology (Berl)"},{"key":"1370_CR33","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/sj.mp.4001948","volume":"12","author":"J Minet-Ringuet","year":"2007","unstructured":"Minet-Ringuet J, Even PC, Valet P, Carpene C, Visentin V, Prevot D, Daviaud D, Quignard-Boulange A, Tome D, de Beaurepaire R (2007) Alterations of lipid metabolism and gene expression in rat adipocytes during chronic olanzapine treatment. Mol Psychiatry 12:562\u2013571","journal-title":"Mol Psychiatry"},{"key":"1370_CR34","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.mp.4001556","volume":"10","author":"S Miyamoto","year":"2005","unstructured":"Miyamoto S, Duncan GE, Marx CE, Lieberman JA (2005) Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol Psychiatry 10:79\u2013104","journal-title":"Mol Psychiatry"},{"key":"1370_CR35","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0091-3057(03)00042-X","volume":"75","author":"B Pouzet","year":"2003","unstructured":"Pouzet B, Mow T, Kreilgaard M, Velschow S (2003) Chronic treatment with antipsychotics in rats as a model for antipsychotic-induced weight gain in human. Pharmacol Biochem Behav 75:133\u2013140","journal-title":"Pharmacol Biochem Behav"},{"key":"1370_CR36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0378-4274(85)90094-3","volume":"25","author":"SC Price","year":"1985","unstructured":"Price SC, Hall DE, Hinton RH (1985) Lipid accumulation in the livers of chlorpromazine-treated rats does not induce peroxisome proliferation. Toxicol Lett 25:11\u201317","journal-title":"Toxicol Lett"},{"key":"1370_CR37","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/01.HYP.0000161995.64192.2b","volume":"45","author":"NR Qi","year":"2005","unstructured":"Qi NR, Wang J, Zidek V, Landa V, Mlejnek P, Kazdova L, Pravenec M, Kurtz TW (2005) A new transgenic rat model of hepatic steatosis and the metabolic syndrome. Hypertension 45:1004\u20131011","journal-title":"Hypertension"},{"key":"1370_CR38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11010-006-9160-4","volume":"289","author":"MB Raeder","year":"2006","unstructured":"Raeder MB, Ferno J, Vik-Mo AO, Steen VM (2006) SREBP Activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: relevance for metabolic side-effects? Mol Cell Biochem 289:167\u2013173","journal-title":"Mol Cell Biochem"},{"key":"1370_CR39","doi-asserted-by":"crossref","first-page":"26839","DOI":"10.1155\/2007\/26839","volume":"2007","author":"M Rakhshandehroo","year":"2007","unstructured":"Rakhshandehroo M, Sanderson LM, Matilainen M, Stienstra R, Carlberg C, de Groot PJ, Muller M, Kersten S (2007) Comprehensive analysis of pparalpha-dependent regulation of hepatic lipid metabolism by expression profiling. PPAR Res 2007:26839","journal-title":"PPAR Res"},{"key":"1370_CR40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/1359786806066040","volume":"20","author":"GP Reynolds","year":"2006","unstructured":"Reynolds GP, Hill MJ, Kirk SL (2006) The 5-HT2C receptor and antipsychoticinduced weight gain\u2013mechanisms and genetics. J Psychopharmacol 20:15\u201318","journal-title":"J Psychopharmacol"},{"key":"1370_CR41","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nrd1346","volume":"3","author":"BL Roth","year":"2004","unstructured":"Roth BL, Sheffler DJ, Kroeze WK (2004) Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nat Rev Drug Discov 3:353\u2013359","journal-title":"Nat Rev Drug Discov"},{"key":"1370_CR42","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1172\/JCI119248","volume":"99","author":"H Shimano","year":"1997","unstructured":"Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL (1997) Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest 99:846\u2013854","journal-title":"J Clin Invest"},{"key":"1370_CR43","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1172\/JCI119247","volume":"99","author":"I Shimomura","year":"1997","unstructured":"Shimomura I, Shimano H, Horton JD, Goldstein JL, Brown MS (1997) Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J Clin Invest 99:838\u2013845","journal-title":"J Clin Invest"},{"key":"1370_CR44","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1101\/gad.12.20.3182","volume":"12","author":"I Shimomura","year":"1998","unstructured":"Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, Goldstein JL, Brown MS (1998) Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev 12:3182\u20133194","journal-title":"Genes Dev"},{"key":"1370_CR45","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1056\/NEJMra043590","volume":"353","author":"AI Shulman","year":"2005","unstructured":"Shulman AI, Mangelsdorf DJ (2005) Retinoid x receptor heterodimers in the metabolic syndrome. N Engl J Med 353:604\u201315","journal-title":"N Engl J Med"},{"key":"1370_CR46","first-page":"245","volume":"21","author":"B Spivak","year":"1998","unstructured":"Spivak B, Roitman S, Vered Y, Mester R, Graff E, Talmon Y, Guy N, Gonen N, Weizman A (1998) Diminished suicidal and aggressive behavior, high plasma norepinephrine levels, and serum triglyceride levels in chronic neuroleptic-resistant schizophrenic patients maintained on clozapine. Clin Neuropharmacol 21:245\u2013250","journal-title":"Clin Neuropharmacol"},{"key":"1370_CR47","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1176\/appi.ajp.158.5.816","volume":"158","author":"FM Theisen","year":"2001","unstructured":"Theisen FM, Cichon S, Linden A, Martin M, Remschmidt H, Hebebrand J (2001) Clozapine and weight gain. Am J Psychiatry 158:816","journal-title":"Am J Psychiatry"},{"key":"1370_CR48","first-page":"779","volume":"16","author":"O Timar","year":"2000","unstructured":"Timar O, Sestier F, Levy E (2000) Metabolic syndrome X: a review. Can J Cardiol 16:779\u2013789","journal-title":"Can J Cardiol"},{"key":"1370_CR49","first-page":"741","volume":"14","author":"KA Tobin","year":"2000","unstructured":"Tobin KA, Steineger HH, Alberti S, Spydevold O, Auwerx J, Gustafsson JA, Nebb HI (2000) Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha. Mol Endocrinol 14:741\u2013752","journal-title":"Mol Endocrinol"},{"key":"1370_CR50","doi-asserted-by":"crossref","first-page":"26192","DOI":"10.1074\/jbc.270.44.26192","volume":"270","author":"PJ Uelmen","year":"1995","unstructured":"Uelmen PJ, Oka K, Sullivan M, Chang CC, Chang TY, Chan L (1995) Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro. J Biol Chem 270:26192\u201326201","journal-title":"J Biol Chem"},{"key":"1370_CR51","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/sj.npp.1301142","volume":"32","author":"HS Vestri","year":"2007","unstructured":"Vestri HS, Maianu L, Moellering DR, Garvey WT (2007) Atypical antipsychotic drugs directly impair insulin action in adipocytes: effects on glucose transport, lipogenesis, and antilipolysis. Neuropsychopharmacology 32:765\u2013772","journal-title":"Neuropsychopharmacology"},{"key":"1370_CR52","first-page":"679","volume":"11","author":"AO Vik-Mo","year":"2008","unstructured":"Vik-Mo AO, Birkenaes AB, Ferno J, Jonsdottir H, Andreassen OA, Steen VM (2008) Increased expression of lipid biosynthesis genes in peripheral blood cells of olanzapine-treated patients. Int J Neuropsychopharmacol 11:679\u2013684","journal-title":"Int J Neuropsychopharmacol"},{"key":"1370_CR53","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.psychres.2004.02.018","volume":"133","author":"PM Wehmeier","year":"2005","unstructured":"Wehmeier PM, Gebhardt S, Schmidtke J, Remschmidt H, Hebebrand J, Theisen FM (2005) Clozapine: weight gain in a pair of monozygotic twins concordant for schizophrenia and mild mental retardation. Psychiatry Res 133:273\u2013276","journal-title":"Psychiatry Res"},{"key":"1370_CR54","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1006\/abio.1999.4085","volume":"270","author":"J Winer","year":"1999","unstructured":"Winer J, Jung CK, Shackel I, Williams PM (1999) Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal Biochem 270:41\u201349","journal-title":"Anal Biochem"},{"key":"1370_CR55","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.phrs.2007.05.007","volume":"56","author":"LH Yang","year":"2007","unstructured":"Yang LH, Chen TM, Yu ST, Chen YH (2007) Olanzapine induces SREBP-1-related adipogenesis in 3T3-L1 cells. Pharmacol Res 56:202\u2013208","journal-title":"Pharmacol Res"},{"key":"1370_CR56","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1210\/me.2002-0190","volume":"17","author":"T Yoshikawa","year":"2003","unstructured":"Yoshikawa T, Ide T, Shimano H, Yahagi N, Amemiya-Kudo M, Matsuzaka T, Yatoh S, Kitamine T, Okazaki H, Tamura Y, Sekiya M, Takahashi A, Hasty AH, Sato R, Sone H, Osuga J, Ishibashi S, Yamada N (2003) Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling. Mol Endocrinol 17:1240\u20131254","journal-title":"Mol Endocrinol"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-008-1370-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-008-1370-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-008-1370-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T14:41:28Z","timestamp":1684593688000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-008-1370-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,30]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["1370"],"URL":"https:\/\/doi.org\/10.1007\/s00213-008-1370-x","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,30]]}}}