{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:14:07Z","timestamp":1791245647025,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2009,1,27]],"date-time":"2009-01-27T00:00:00Z","timestamp":1233014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1007\/s00213-009-1472-0","type":"journal-article","created":{"date-parts":[[2009,1,25]],"date-time":"2009-01-25T22:20:33Z","timestamp":1232922033000},"page":"423-429","source":"Crossref","is-referenced-by-count":91,"title":["Abnormal pain response in pain-sensitive opiate addicts after prolonged abstinence predicts increased drug craving"],"prefix":"10.1007","volume":"204","author":[{"given":"Zhen-Yu","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,1,27]]},"reference":[{"key":"1472_CR1","first-page":"238","volume":"13","author":"Y Akvardar","year":"2002","unstructured":"Akvardar Y, Turkcan A, Cakmak D (2002) Is substance abuse among physicians a problem? Turk Psikiyatri Derg 13:238\u2013244","journal-title":"Turk Psikiyatri Derg"},{"key":"1472_CR2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.7326\/0003-4819-144-2-200601170-00010","volume":"144","author":"DP Alford","year":"2006","unstructured":"Alford DP, Compton P, Samet JH (2006) Acute pain management for patients receiving maintenance methadone or buprenorphine therapy. Ann Intern Med 144:127\u2013134","journal-title":"Ann Intern Med"},{"key":"1472_CR3","doi-asserted-by":"crossref","first-page":"9608","DOI":"10.1073\/pnas.95.16.9608","volume":"95","author":"C Bond","year":"1998","unstructured":"Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, Gong J, Schluger J, Strong JA, Leal SM, Tischfield JA, Kreek MJ, Yu L (1998) Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci U S A 95:9608\u20139613","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1472_CR4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.drugalcdep.2003.10.012","volume":"73","author":"B Brands","year":"2004","unstructured":"Brands B, Blake J, Sproule B, Gourlay D, Busto U (2004) Prescription opioid abuse in patients presenting for methadone maintenance treatment. Drug Alcohol Depend 73:199\u2013207","journal-title":"Drug Alcohol Depend"},{"key":"1472_CR5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuroimage.2005.03.041","volume":"27","author":"JC Brooks","year":"2005","unstructured":"Brooks JC, Zambreanu L, Godinez A, Craig AD, Tracey I (2005) Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging. Neuroimage 27:201\u2013209","journal-title":"Neuroimage"},{"key":"1472_CR6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jsat.2005.11.007","volume":"30","author":"DA Calsyn","year":"2006","unstructured":"Calsyn DA, Malcy JA, Saxon AJ (2006) Slow tapering from methadone maintenance in a program encouraging indefinite maintenance. J Subst Abuse Treat 30:159\u2013163","journal-title":"J Subst Abuse Treat"},{"key":"1472_CR7","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.1360-0443.1999.9433273.x","volume":"94","author":"BL Carter","year":"1999","unstructured":"Carter BL, Tiffany ST (1999) Meta-analysis of cue-reactivity in addiction research. Addiction 94:327\u2013340","journal-title":"Addiction"},{"key":"1472_CR8","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1523\/JNEUROSCI.21-11-04074.2001","volume":"21","author":"E Celerier","year":"2001","unstructured":"Celerier E, Laulin JP, Corcuff JB, Le Moal M, Simonnet G (2001) Progressive enhancement of delayed hyperalgesia induced by repeated heroin administration: a sensitization process. J Neurosci 21:4074\u20134080","journal-title":"J Neurosci"},{"key":"1472_CR9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0304-3959(89)90126-7","volume":"37","author":"AC Chen","year":"1989","unstructured":"Chen AC, Dworkin SF, Haug J, Gehrig J (1989) Human pain responsivity in a tonic pain model: psychological determinants. Pain 37:143\u2013160","journal-title":"Pain"},{"key":"1472_CR10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1176\/ajp.156.1.11","volume":"156","author":"AR Childress","year":"1999","unstructured":"Childress AR, Mozley PD, McElgin W, Fitzgerald J, Reivich M, O'Brien CP (1999) Limbic activation during cue-induced cocaine craving. Am J Psychiatry 156:11\u201318","journal-title":"Am J Psychiatry"},{"key":"1472_CR11","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/AJP.0b013e31816b2f43","volume":"24","author":"LF Chu","year":"2008","unstructured":"Chu LF, Angst MS, Clark D (2008) Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerations. Clin J Pain 24:479\u2013496","journal-title":"Clin J Pain"},{"key":"1472_CR12","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/0885-3924(94)90203-8","volume":"9","author":"MA Compton","year":"1994","unstructured":"Compton MA (1994) Cold-pressor pain tolerance in opiate and cocaine abusers: correlates of drug type and use status. J Pain Symptom Manage 9:462\u2013473","journal-title":"J Pain Symptom Manage"},{"key":"1472_CR13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0885-3924(00)00191-3","volume":"20","author":"P Compton","year":"2000","unstructured":"Compton P, Charuvastra VC, Kintaudi K, Ling W (2000) Pain responses in methadone-maintained opioid abusers. J Pain Symptom Manage 20:237\u2013245","journal-title":"J Pain Symptom Manage"},{"key":"1472_CR14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0376-8716(00)00200-3","volume":"63","author":"P Compton","year":"2001","unstructured":"Compton P, Charuvastra VC, Ling W (2001) Pain intolerance in opioid-maintained former opiate addicts: effect of long-acting maintenance agent. Drug Alcohol Depend 63:139\u2013146","journal-title":"Drug Alcohol Depend"},{"key":"1472_CR15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1526-4637.2006.00224.x","volume":"9","author":"RA Cruciani","year":"2008","unstructured":"Cruciani RA, Esteban S, Seewald RM, Altilio T, Bookbinder M, Sheu R, Portenoy RK (2008) MMTP patients with chronic pain switching to pain management clinics. A problem or an acceptable practice? Pain Med 9:359\u2013364","journal-title":"Pain Med"},{"key":"1472_CR16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/01616412.2000.11740676","volume":"22","author":"KD Davis","year":"2000","unstructured":"Davis KD (2000) The neural circuitry of pain as explored with functional MRI. Neurol Res 22:313\u2013317","journal-title":"Neurol Res"},{"key":"1472_CR17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0304-3959(00)00391-2","volume":"90","author":"M Doverty","year":"2001","unstructured":"Doverty M, White JM, Somogyi AA, Bochner F, Ali R, Ling W (2001) Hyperalgesic responses in methadone maintenance patients. Pain 90:91\u201396","journal-title":"Pain"},{"key":"1472_CR18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3171\/jns.1962.19.2.0089","volume":"19","author":"EL Foltz","year":"1962","unstructured":"Foltz EL, White LE Jr (1962) Pain \u201crelief\u201d by frontal cingulumotomy. J Neurosurg 19:89\u2013100","journal-title":"J Neurosurg"},{"key":"1472_CR19","first-page":"353","volume":"6","author":"EL Foltz","year":"1968","unstructured":"Foltz EL, White LE (1968) The role of rostral cingulumotomy in \u201cpain\u201d relief. Int J Neurol 6:353\u201373","journal-title":"Int J Neurol"},{"key":"1472_CR20","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.psyneuen.2005.05.002","volume":"30","author":"HC Fox","year":"2005","unstructured":"Fox HC, Talih M, Malison R, Anderson GM, Kreek MJ, Sinha R (2005) Frequency of recent cocaine and alcohol use affects drug craving and associated responses to stress and drug-related cues. Psychoneuroendocrinology 30:880\u2013891","journal-title":"Psychoneuroendocrinology"},{"key":"1472_CR21","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1530-0277.2006.00320.x","volume":"31","author":"HC Fox","year":"2007","unstructured":"Fox HC, Bergquist KL, Hong KI, Sinha R (2007) Stress-induced and alcohol cue-induced craving in recently abstinent alcohol-dependent individuals. Alcohol Clin Exp Res 31:395\u2013403","journal-title":"Alcohol Clin Exp Res"},{"key":"1472_CR22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/35084134","volume":"412","author":"JW Grimm","year":"2001","unstructured":"Grimm JW, Hope BT, Wise RA, Shaham Y (2001) Neuroadaptation. Incubation of cocaine craving after withdrawal. Nature 412:141\u2013142","journal-title":"Nature"},{"key":"1472_CR23","doi-asserted-by":"crossref","first-page":"392","DOI":"10.3181\/00379727-162-40689","volume":"162","author":"A Ho","year":"1979","unstructured":"Ho A, Dole VP (1979) Pain perception in drug-free and in methadone-maintained human ex-addicts. Proc Soc Exp Biol Med 162:392\u2013395","journal-title":"Proc Soc Exp Biol Med"},{"key":"1472_CR24","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/neurosurgery\/21.CN_suppl_1.334","volume":"21","author":"RW Hurt","year":"1974","unstructured":"Hurt RW, Ballantine HT Jr (1974) Stereotactic anterior cingulate lesions for persistent pain: a report on 68 cases. Clin Neurosurg 21:334\u2013351","journal-title":"Clin Neurosurg"},{"key":"1472_CR25","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1016\/j.addbeh.2007.04.025","volume":"32","author":"SD LaRowe","year":"2007","unstructured":"LaRowe SD, Saladin ME, Carpenter MJ, Upadhyaya HP (2007) Reactivity to nicotine cues over repeated cue reactivity sessions. Addict Behav 32:2888\u20132899","journal-title":"Addict Behav"},{"key":"1472_CR26","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0306-4522(98)00652-6","volume":"89","author":"JP Laulin","year":"1999","unstructured":"Laulin JP, Celerier E, Larcher A, Le Moal M, Simonnet G (1999) Opiate tolerance to daily heroin administration: an apparent phenomenon associated with enhanced pain sensitivity. Neuroscience 89:631\u2013636","journal-title":"Neuroscience"},{"key":"1472_CR27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1360-0443.1997.tb03648.x","volume":"92","author":"M Lehofer","year":"1997","unstructured":"Lehofer M, Liebmann PM, Moser M, Legl T, Pernhaupt G, Schauenstein K, Zapotoczky HG (1997) Decreased nociceptive sensitivity: a biological risk marker for opiate dependence? Addiction 92:163\u2013166","journal-title":"Addiction"},{"key":"1472_CR28","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0140-6736(94)91697-7","volume":"344","author":"PM Liebman","year":"1994","unstructured":"Liebman PM, Lehofer M, Schonauer-Cejpek M, Legl T, Pernhaupt G, Moser M, Schauenstein K (1994) Pain sensitivity in former opioid addicts. Lancet 344:1031\u20131032","journal-title":"Lancet"},{"key":"1472_CR29","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/S0006-3223(97)00337-5","volume":"42","author":"PM Liebmann","year":"1997","unstructured":"Liebmann PM, Lehofer M, Moser M, Hoehn-Saric R, Legl T, Pernhaupt G, Schauenstein K (1997) Persistent analgesia in former opiate addicts is resistant to blockade of endogenous opioids. Biol Psychiatry 42:962\u2013964","journal-title":"Biol Psychiatry"},{"key":"1472_CR30","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1523\/JNEUROSCI.14-04-02301.1994","volume":"14","author":"J Mao","year":"1994","unstructured":"Mao J, Price DD, Mayer DJ (1994) Thermal hyperalgesia in association with the development of morphine tolerance in rats: roles of excitatory amino acid receptors and protein kinase C. J Neurosci 14:2301\u20132312","journal-title":"J Neurosci"},{"key":"1472_CR31","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.2044-8260.1965.tb00467.x","volume":"4","author":"JE Martin","year":"1965","unstructured":"Martin JE, Inglis J (1965) Pain tolerance and narcotic addiction. Br J Soc Clin Psychol 4:224\u2013229","journal-title":"Br J Soc Clin Psychol"},{"key":"1472_CR32","doi-asserted-by":"crossref","first-page":"7744","DOI":"10.1073\/pnas.96.14.7744","volume":"96","author":"JS Mogil","year":"1999","unstructured":"Mogil JS (1999) The genetic mediation of individual differences in sensitivity to pain and its inhibition. Proc Natl Acad Sci U S A 96:7744\u20137751","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1472_CR33","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1073\/pnas.93.7.3048","volume":"93","author":"JS Mogil","year":"1996","unstructured":"Mogil JS, Sternberg WF, Marek P, Sadowski B, Belknap JK, Liebeskind JC (1996) The genetics of pain and pain inhibition. Proc Natl Acad Sci U S A 93:3048\u20133055","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1472_CR34","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1530-0277.2006.00019.x","volume":"30","author":"W Ooteman","year":"2006","unstructured":"Ooteman W, Koeter MW, Vserheul R, Schippers GM, van den Brink W (2006) Measuring craving: an attempt to connect subjective craving with cue reactivity. Alcohol Clin Exp Res 30:57\u201369","journal-title":"Alcohol Clin Exp Res"},{"key":"1472_CR35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0304-3959(83)90126-4","volume":"17","author":"DD Price","year":"1983","unstructured":"Price DD, McGrath PA, Rafii A, Buckingham B (1983) The validation of visual analogue scales as ratio scale measures for chronic and experimental pain. Pain 17:45\u201356","journal-title":"Pain"},{"key":"1472_CR36","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.drugalcdep.2005.09.007","volume":"82","author":"D Pud","year":"2006","unstructured":"Pud D, Cohen D, Lawental E, Eisenberg E (2006) Opioids and abnormal pain perception: New evidence from a study of chronic opioid addicts and healthy subjects. Drug Alcohol Depend 82:218\u2013223","journal-title":"Drug Alcohol Depend"},{"key":"1472_CR37","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.pbb.2008.08.023","volume":"91","author":"ZY Ren","year":"2009","unstructured":"Ren ZY, Zhang XL, Liu Y, Zhao LY, Shi J, Bao Y, Zhang XY, Kosten TR, Lu L (2009) Diurnal variation in cue-induced responses among protracted abstinent heroin users. Pharmacol Biochem Behav 91:468\u2013472","journal-title":"Pharmacol Biochem Behav"},{"key":"1472_CR38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.pbb.2007.04.010","volume":"87","author":"J Shi","year":"2007","unstructured":"Shi J, Zhao LY, Epstein DH, Zhang XL, Lu L (2007) Long-term methadone maintenance reduces protracted symptoms of heroin abstinence and cue-induced craving in Chinese heroin abusers. Pharmacol Biochem Behav 87:141\u2013145","journal-title":"Pharmacol Biochem Behav"},{"key":"1472_CR39","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.1093535","volume":"303","author":"T Singer","year":"2004","unstructured":"Singer T, Seymour B, O'Doherty J, Kaube H, Dolan RJ, Frith CD (2004) Empathy for pain involves the affective but not sensory components of pain. Science 303:1157\u20131162","journal-title":"Science"},{"key":"1472_CR40","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s00213-003-1525-8","volume":"170","author":"R Sinha","year":"2003","unstructured":"Sinha R, Talih M, Malison R, Cooney N, Anderson GM, Kreek MJ (2003) Hypothalamic\u2013pituitary\u2013adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states. Psychopharmacology (Berl) 170:62\u201372","journal-title":"Psychopharmacology (Berl)"},{"key":"1472_CR41","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.2003220","volume":"251","author":"JD Talbot","year":"1991","unstructured":"Talbot JD, Marrett S, Evans AC, Meyer E, Bushnell MC, Duncan GH (1991) Multiple representations of pain in human cerebral cortex. Science 251:1355\u20131358","journal-title":"Science"},{"key":"1472_CR42","volume-title":"Pain and behavioral medicine: theory, research, and a clinical guide","author":"D Turk","year":"1983","unstructured":"Turk D, Meichenbaum D, Genest M (1983) Pain and behavioral medicine: theory, research, and a clinical guide. Guildford Press, New York, USA"},{"key":"1472_CR43","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.addbeh.2004.02.040","volume":"29","author":"HP Upadhyaya","year":"2004","unstructured":"Upadhyaya HP, Drobes DJ, Thomas SE (2004) Reactivity to smoking cues in adolescent cigarette smokers. Addict Behav 29:849\u2013856","journal-title":"Addict Behav"},{"key":"1472_CR44","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1046\/j.1360-0443.2003.00465.x","volume":"98","author":"AJ Waters","year":"2003","unstructured":"Waters AJ, Shiffman S, Bradley BP, Mogg K (2003) Attentional shifts to smoking cues in smokers. Addiction 98:1409\u20131417","journal-title":"Addiction"},{"key":"1472_CR45","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0376-8716(97)00098-7","volume":"48","author":"A Weinstein","year":"1997","unstructured":"Weinstein A, Wilson S, Bailey J, Myles J, Nutt D (1997) Imagery of craving in opiate addicts undergoing detoxification. Drug Alcohol Depend 48:25\u201331","journal-title":"Drug Alcohol Depend"},{"key":"1472_CR46","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.addbeh.2004.06.007","volume":"29","author":"JM White","year":"2004","unstructured":"White JM (2004) Pleasure into pain: the consequences of long-term opioid use. Addict Behav 29:1311\u20131324","journal-title":"Addict Behav"},{"key":"1472_CR47","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.pbb.2007.01.008","volume":"86","author":"J Yu","year":"2007","unstructured":"Yu J, Zhang S, Epstein DH, Fang Y, Shi J, Qin H, Yao S, Le Foll B, Lu L (2007) Gender and stimulus difference in cue-induced responses in abstinent heroin users. Pharmacol Biochem Behav 86:485\u2013492","journal-title":"Pharmacol Biochem Behav"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-009-1472-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-009-1472-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-009-1472-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T16:06:56Z","timestamp":1558627616000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-009-1472-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,27]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["1472"],"URL":"https:\/\/doi.org\/10.1007\/s00213-009-1472-0","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,27]]}}}