{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:40:09Z","timestamp":1791218409695,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,8,18]],"date-time":"2009-08-18T00:00:00Z","timestamp":1250553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1007\/s00213-009-1639-8","type":"journal-article","created":{"date-parts":[[2009,8,17]],"date-time":"2009-08-17T06:29:29Z","timestamp":1250490569000},"page":"119-125","source":"Crossref","is-referenced-by-count":78,"title":["Olanzapine-induced weight gain in the rat: role of 5-HT2C and histamine H1 receptors"],"prefix":"10.1007","volume":"207","author":[{"given":"Shona L.","family":"Kirk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Glazebrook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Grayson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna C.","family":"Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin P.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,8,18]]},"reference":[{"key":"1639_CR1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/oby.2006.6","volume":"14","author":"VL Albaugh","year":"2006","unstructured":"Albaugh VL, Henry CR, Bello NT, Hajnal A, Lynch SL, Halle B, Lynch CJ (2006) Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents. Obesity (Silver Spring) 14:36\u201351","journal-title":"Obesity (Silver Spring)"},{"key":"1639_CR2","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1176\/ajp.156.11.1686","volume":"156","author":"DB Allison","year":"1999","unstructured":"Allison DB, Mentore JL, Heo M, Chandler LP, Cappelleri JC, Infante MC, Weiden PJ (1999) Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 156:1686\u20131696","journal-title":"Am J Psychiatry"},{"key":"1639_CR3","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0091-3057(87)90340-6","volume":"27","author":"T Baptista","year":"1987","unstructured":"Baptista T, Parada M, Hernandez L (1987) Long term administration of some antipsychotic drugs increases body weight and feeding in rats. Are D2 dopamine receptors involved? Pharmacol Biochem Behav 27:399\u2013405","journal-title":"Pharmacol Biochem Behav"},{"key":"1639_CR4","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1124\/jpet.106.104448","volume":"319","author":"KA Berg","year":"2006","unstructured":"Berg KA, Navailles S, Sanchez TA, Silva YM, Wood MD, Spampinato U, Clarke WP (2006) Differential effects of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxyl]-5-pyridyl]carbamoyl]-6-trifluoromethylindone (SB 243213) on 5-hydroxytryptamine(2C) receptor-mediated responses. J Pharmacol Exp Ther 319:260\u2013268","journal-title":"J Pharmacol Exp Ther"},{"key":"1639_CR5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0028-3908(97)00049-X","volume":"36","author":"DW Bonhaus","year":"1997","unstructured":"Bonhaus DW, Weinhardt KK, Taylor M, DeSouza A, McNeeley PM, Szczepanski K, Fontana DJ, Trinh J, Rocha CL, Dawson MW, Flippin LA, Eglen RM (1997) RS-102221: a novel high affinity and selective, 5-HT2C receptor antagonist. Neuropharmacology 36:621\u2013629","journal-title":"Neuropharmacology"},{"key":"1639_CR6","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s002130000504","volume":"152","author":"PG Clifton","year":"2000","unstructured":"Clifton PG, Lee MD, Dourish CT (2000) Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist and d-fenfluramine on feeding patterns in the rat. Psychopharmacology (Berl) 152:256\u2013267","journal-title":"Psychopharmacology (Berl)"},{"key":"1639_CR7","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.neuropharm.2006.01.006","volume":"50","author":"SJ Cooper","year":"2006","unstructured":"Cooper SJ, Al-Naser HA (2006) Dopaminergic control of food choice: contrasting effects of SKF 38393 and quinpirole on high-palatability food preference in the rat. Neuropharmacology 50:953\u2013963","journal-title":"Neuropharmacology"},{"key":"1639_CR8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s00213-005-2224-4","volume":"181","author":"GD Cooper","year":"2005","unstructured":"Cooper GD, Pickavance LC, Wilding JP, Halford JC, Goudie AJ (2005) A parametric analysis of olanzapine-induced weight gain in female rats. Psychopharmacology (Berl) 181:80\u201389","journal-title":"Psychopharmacology (Berl)"},{"key":"1639_CR9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1177\/0269881106069637","volume":"21","author":"GD Cooper","year":"2007","unstructured":"Cooper GD, Pickavance LC, Wilding JP, Harrold JA, Halford G, Goudie AJ (2007) Effects of olanzapine in male rats: enhanced adiposity in the absence of hyperphagia, weight gain or metabolic abnormalities. J Psychopharmacol 21:405\u2013413","journal-title":"J Psychopharmacol"},{"key":"1639_CR10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/FBP.0b013e3282f62c66","volume":"19","author":"N Davoodi","year":"2008","unstructured":"Davoodi N, Kalinichev M, Clifton PG (2008) Comparative effects of olanzapine and ziprasidone on hypophagia induced by enhanced histamine neurotransmission in the rat. Behav Pharmacol 19:121\u2013128","journal-title":"Behav Pharmacol"},{"key":"1639_CR11","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1177\/0269881104042613","volume":"18","author":"MJ Fell","year":"2004","unstructured":"Fell MJ, Marshall KM, Williams J, Neill JC (2004a) Effects of the atypical antipsychotic olanzapine on reproductive function and weight gain in female rats. J Psychopharmacol 18:149\u2013155","journal-title":"J Psychopharmacol"},{"key":"1639_CR12","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.euroneuro.2003.12.001","volume":"14","author":"MJ Fell","year":"2004","unstructured":"Fell MJ, Neill JC, Marshall KM (2004b) Effects of the classical antipsychotic haloperidol and atypical antipsychotic risperidone on weight gain, the oestrous cycle and uterine weight in female rats. Eur Neuropsychopharmacol 14:385\u2013392","journal-title":"Eur Neuropsychopharmacol"},{"key":"1639_CR13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00213-007-0833-9","volume":"194","author":"MJ Fell","year":"2007","unstructured":"Fell MJ, Anjum N, Dickinson K, Marshall KM, Peltola LM, Vickers S, Cheetham S, Neill JC (2007) The distinct effects of subchronic antipsychotic drug treatment on macronutrient selection, body weight, adiposity, and metabolism in female rats. Psychopharmacology (Berl) 194:221\u2013231","journal-title":"Psychopharmacology (Berl)"},{"key":"1639_CR14","first-page":"R605","volume":"256","author":"K Fukagawa","year":"1989","unstructured":"Fukagawa K, Sakata T, Shiraishi T, Yoshimatsu H, Fujimoto K, Ookuma K, Wada H (1989) Neuronal histamine modulates feeding behavior through H1-receptor in rat hypothalamus. Am J Physiol 256:R605\u2013611","journal-title":"Am J Physiol"},{"key":"1639_CR15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0361-9230(85)90006-1","volume":"15","author":"DB Gilbert","year":"1985","unstructured":"Gilbert DB, Cooper SJ (1985) Analysis of dopamine D1 and D2 receptor involvement in d- and l-amphetamine-induced anorexia in rats. Brain Res Bull 15:385\u2013389","journal-title":"Brain Res Bull"},{"key":"1639_CR16","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.psyneuen.2008.01.018","volume":"33","author":"M Han","year":"2008","unstructured":"Han M, Deng C, Burne TH, Newell KA, Huang XF (2008) Short- and long-term effects of antipsychotic drug treatment on weight gain and H1 receptor expression. Psychoneuroendocrinology 33:569\u2013580","journal-title":"Psychoneuroendocrinology"},{"key":"1639_CR17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0091-3057(03)00221-1","volume":"76","author":"AW Hartfield","year":"2003","unstructured":"Hartfield AW, Moore NA, Clifton PG (2003) Serotonergic and histaminergic mechanisms involved in intralipid drinking? Pharmacol Biochem Behav 76:251\u2013258","journal-title":"Pharmacol Biochem Behav"},{"key":"1639_CR18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00213-004-2019-z","volume":"178","author":"A Hayashi","year":"2005","unstructured":"Hayashi A, Suzuki M, Sasamata M, Miyata K (2005) Agonist diversity in 5-HT(2C) receptor-mediated weight control in rats. Psychopharmacology (Berl) 178:241\u2013249","journal-title":"Psychopharmacology (Berl)"},{"key":"1639_CR19","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0031-9384(88)90324-1","volume":"44","author":"L Hernandez","year":"1988","unstructured":"Hernandez L, Hoebel BG (1988) Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens. Physiol Behav 44:599\u2013606","journal-title":"Physiol Behav"},{"key":"1639_CR20","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0022-3565(24)38891-3","volume":"295","author":"K Herrick-Davis","year":"2000","unstructured":"Herrick-Davis K, Grinde E, Teitler M (2000) Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors. J Pharmacol Exp Ther 295:226\u2013232","journal-title":"J Pharmacol Exp Ther"},{"key":"1639_CR21","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/sj.bjp.0701311","volume":"121","author":"HC Jackson","year":"1997","unstructured":"Jackson HC, Bearham MC, Hutchins LJ, Mazurkiewicz SE, Needham AM, Heal DJ (1997) Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenaline reuptake inhibitor, sibutramine, in the rat. Br J Pharmacol 121:1613\u20131618","journal-title":"Br J Pharmacol"},{"key":"1639_CR22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/s00213-005-0081-9","volume":"182","author":"M Kalinichev","year":"2005","unstructured":"Kalinichev M, Rourke C, Daniels AJ, Grizzle MK, Britt CS, Ignar DM, Jones DN (2005) Characterisation of olanzapine-induced weight gain and effect of aripiprazole vs olanzapine on body weight and prolactin secretion in female rats. Psychopharmacology (Berl) 182:220\u2013231","journal-title":"Psychopharmacology (Berl)"},{"key":"1639_CR23","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0028-3908(97)00038-5","volume":"36","author":"GA Kennett","year":"1997","unstructured":"Kennett GA, Wood MD, Bright F, Trail B, Riley G, Holland V, Avenell KY, Stean T, Upton N, Bromidge S, Forbes IT, Brown AM, Middlemiss DN, Blackburn TP (1997) SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 36:609\u2013620","journal-title":"Neuropharmacology"},{"key":"1639_CR24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ejphar.2004.10.015","volume":"505","author":"SL Kirk","year":"2004","unstructured":"Kirk SL, Neill JC, Jones DN, Reynolds GP (2004) Ziprasidone suppresses olanzapine-induced increases in ingestive behaviour in the rat. Eur J Pharmacol 505:253\u2013254","journal-title":"Eur J Pharmacol"},{"key":"1639_CR25","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/sj.npp.1300027","volume":"28","author":"WK Kroeze","year":"2003","unstructured":"Kroeze WK, Hufeisen SJ, Popadak BA, Renock SM, Steinberg S, Ernsberger P, Jayathilake K, Meltzer HY, Roth BL (2003) H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28:519\u2013526","journal-title":"Neuropsychopharmacology"},{"key":"1639_CR26","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0091-3057(97)00465-6","volume":"59","author":"A Lecklin","year":"1998","unstructured":"Lecklin A, Tuomisto L (1998) The blockade of H1 receptors attenuates the suppression of feeding and diuresis induced by inhibition of histamine catabolism. Pharmacol Biochem Behav 59:753\u2013758","journal-title":"Pharmacol Biochem Behav"},{"key":"1639_CR27","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0091-3057(95)00187-5","volume":"53","author":"P Martel","year":"1996","unstructured":"Martel P, Fantino M (1996) Mesolimbic dopaminergic system activity as a function of food reward: a microdialysis study. Pharmacol Biochem Behav 53:221\u2013226","journal-title":"Pharmacol Biochem Behav"},{"key":"1639_CR28","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2133\/dmpk.20.368","volume":"20","author":"A Matsui-Sakata","year":"2005","unstructured":"Matsui-Sakata A, Ohtani H, Sawada Y (2005) Receptor occupancy-based analysis of the contributions of various receptors to antipsychotics-induced weight gain and diabetes mellitus. Drug Metab Pharmacokinet 20:368\u2013378","journal-title":"Drug Metab Pharmacokinet"},{"key":"1639_CR29","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.appet.2006.01.008","volume":"46","author":"J Minet-Ringuet","year":"2006","unstructured":"Minet-Ringuet J, Even PC, Goubern M, Tom\u00e9 D, de Beaurepaire R (2006) Long term treatment with olanzapine mixed with the food in male rats induces body fat deposition with no increase in body weight and no thermogenic alteration. Appetite 46:254\u2013262","journal-title":"Appetite"},{"key":"1639_CR30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0022-3565(24)29304-6","volume":"299","author":"L Rauser","year":"2001","unstructured":"Rauser L, Savage JE, Meltzer HY, Roth BL (2001) Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor. J Pharmacol Exp Ther 299:83\u201389","journal-title":"J Pharmacol Exp Ther"},{"key":"1639_CR31","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1177\/026988110401800303","volume":"18","author":"GP Reynolds","year":"2004","unstructured":"Reynolds GP (2004) Receptor mechanisms in the treatment of schizophrenia. J Psychopharmacol 18:340\u2013345","journal-title":"J Psychopharmacol"},{"key":"1639_CR32","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0006-8993(88)91423-0","volume":"441","author":"T Sakata","year":"1988","unstructured":"Sakata T, Ookuma K, Fukagawa K, Fujimoto K, Yoshimatsu H, Shiraishi T, Wada H (1988) Blockade of the histamine H1-receptor in the rat ventromedial hypothalamus and feeding elicitation. Brain Res 441:403\u2013407","journal-title":"Brain Res"},{"key":"1639_CR33","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF02245606","volume":"124","author":"A Schotte","year":"1996","unstructured":"Schotte A, Janssen PF, Gommeren W, Luyten WH, Van Gompel P, Lesage AS, De Loore K, Leysen JE (1996) Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl) 124:57\u201373","journal-title":"Psychopharmacology (Berl)"},{"key":"1639_CR34","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1177\/0269881107081519","volume":"22","author":"S Snigdha","year":"2008","unstructured":"Snigdha S, Thumbi C, Reynolds GP, Neill JC (2008) Ziprasidone and aripiprazole attenuate olanzapine-induced hyperphagia in rats. J Psychopharmacol 22:567\u201371","journal-title":"J Psychopharmacol"},{"key":"1639_CR35","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0140-6736(00)03643-6","volume":"357","author":"GJ Wang","year":"2001","unstructured":"Wang GJ, Volkow ND, Logan J, Pappas NR, Wong CT, Zhu W, Netusil N, Fowler JS (2001) Brain dopamine and obesity. Lancet 357:354\u2013357","journal-title":"Lancet"},{"key":"1639_CR36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2165\/00002018-200124010-00005","volume":"24","author":"T Wetterling","year":"2001","unstructured":"Wetterling T (2001) Bodyweight gain with atypical antipsychotics. A comparative review. Drug Saf 24:59\u201373","journal-title":"Drug Saf"},{"key":"1639_CR37","doi-asserted-by":"crossref","first-page":"358","DOI":"10.4088\/JCP.v60n0602","volume":"60","author":"DA Wirshing","year":"1999","unstructured":"Wirshing DA, Wirshing WC, Kysar L, Berisford MA, Goldstein D, Pashdag J, Mintz J, Marder SR (1999) Novel antipsychotics: comparison of weight gain liabilities. J Clin Psychiatry 60:358\u2013363","journal-title":"J Clin Psychiatry"},{"key":"1639_CR38","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0028-3908(01)00054-5","volume":"41","author":"MD Wood","year":"2001","unstructured":"Wood MD, Reavill C, Trail B, Wilson A, Stean T, Kennett GA, Lightowler S, Blackburn TP, Thomas D, Gager TL, Riley G, Holland V, Bromidge SM, Forbes IT, Middlemiss DN (2001) SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety. Neuropharmacology 41:186\u2013199","journal-title":"Neuropharmacology"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-009-1639-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-009-1639-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-009-1639-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T19:28:17Z","timestamp":1739302097000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-009-1639-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8,18]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["1639"],"URL":"https:\/\/doi.org\/10.1007\/s00213-009-1639-8","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8,18]]}}}