{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:19:41Z","timestamp":1790255981827,"version":"4.1.0"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1007\/s00213-009-1744-8","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T10:06:44Z","timestamp":1261044404000},"page":"443-454","source":"Crossref","is-referenced-by-count":68,"title":["GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior"],"prefix":"10.1007","volume":"208","author":[{"given":"Jared W.","family":"Young","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K. L.","family":"Goey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpi","family":"Minassian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin P.","family":"Paulus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Geyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,12,18]]},"reference":[{"key":"1744_CR1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbr.2004.08.015","volume":"158","author":"R Arban","year":"2005","unstructured":"Arban R, Maraia G, Brackenborough K, Winyard L, Wilson A, Gerrard P, Large C (2005) Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania. Behav Brain Res 158:123\u2013132","journal-title":"Behav Brain Res"},{"key":"1744_CR2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/hup.480","volume":"18","author":"SJ Asghar","year":"2003","unstructured":"Asghar SJ, Tanay VA, Baker GB, Greenshaw A, Silverstone PH (2003) Relationship of plasma amphetamine levels to physiological, subjective, cognitive and biochemical measures in healthy volunteers. Hum Psychopharmacol 18:291\u2013299","journal-title":"Hum Psychopharmacol"},{"key":"1744_CR3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0091-3057(87)90555-7","volume":"26","author":"PJ Bushnell","year":"1987","unstructured":"Bushnell PJ (1987) Effects of scopolamine on locomotor activity and metabolic rate in mice. Pharmacol Biochem Behav 26:195\u2013198","journal-title":"Pharmacol Biochem Behav"},{"key":"1744_CR4","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/sj.npp.1300966","volume":"31","author":"B Cagniard","year":"2006","unstructured":"Cagniard B, Balsam PD, Brunner D, Zhuang X (2006) Mice with chronically elevated dopamine exhibit enhanced motivation, but not learning, for a food reward. Neuropsychopharmacology 31:1362\u20131370","journal-title":"Neuropsychopharmacology"},{"key":"1744_CR5","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0278-5846(90)90023-A","volume":"14","author":"P Cappeliez","year":"1990","unstructured":"Cappeliez P, Moore E (1990) Effects of lithium on an amphetamine animal model of bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 14:347\u2013358","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"1744_CR6","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1002\/jps.2600620922","volume":"62","author":"AK Cho","year":"1973","unstructured":"Cho AK, Hodson BJ, Lindeke B, Miwa GT (1973) Application of quantitative GC\u2013mass spectrometry to study of pharmacokinetics of amphetamine and phentermine. J Pharmacol Sci 62:1491\u20131494","journal-title":"J Pharmacol Sci"},{"key":"1744_CR7","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.2042-7158.1979.tb13602.x","volume":"31","author":"C Collins","year":"1979","unstructured":"Collins C, Laird RI, Richards PT, Starmer GA, Weyrauch S (1979) Aspirin\u2013caffeine interaction in the rat. J Pharm Pharmacol 31:611\u2013614","journal-title":"J Pharm Pharmacol"},{"key":"1744_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/YCO.0b013e3280117733","volume":"20","author":"JF Cryan","year":"2007","unstructured":"Cryan JF, Slattery DA (2007) Animal models of mood disorders: recent developments. Curr Opin Psychiatry 20:1\u20137","journal-title":"Curr Opin Psychiatry"},{"key":"1744_CR9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.yebeh.2007.09.023","volume":"12","author":"D Dencker","year":"2008","unstructured":"Dencker D, Dias R, Pedersen ML, Husum H (2008) Effect of the new antiepileptic drug retigabine in a rodent model of mania. Epilepsy Behav 12:49\u201353","journal-title":"Epilepsy Behav"},{"key":"1744_CR10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0166-4328(89)80102-0","volume":"34","author":"D Eilam","year":"1989","unstructured":"Eilam D, Golani I (1989) Home base behavior of rats (Rattus norvegicus) exploring a novel environment. Behav Brain Res 34:199\u2013211","journal-title":"Behav Brain Res"},{"key":"1744_CR11","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s10519-006-9093-4","volume":"37","author":"H Einat","year":"2006","unstructured":"Einat H (2006a) Establishment of a battery of simple models for facets of bipolar disorder: a practical approach to achieve increased validity, better screening and possible insights into endophenotypes of disease. Behav Genet 37:244\u2013255","journal-title":"Behav Genet"},{"key":"1744_CR12","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1177\/0269881106060241","volume":"20","author":"H Einat","year":"2006","unstructured":"Einat H (2006b) Modelling facets of mania\u2014new directions related to the notion of endophenotypes. J Psychopharmacol 20:714\u2013722","journal-title":"J Psychopharmacol"},{"key":"1744_CR13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF00421184","volume":"44","author":"SE File","year":"1975","unstructured":"File SE, Wardill AG (1975) Validity of head-dipping as a measure of exploration in a modified hole-board. Psychopharmacologia 44:53\u201359","journal-title":"Psychopharmacologia"},{"key":"1744_CR14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0091-3057(79)90292-2","volume":"11","author":"JS Fink","year":"1979","unstructured":"Fink JS, Smith GP (1979) Abnormal pattern of amphetamine locomotion after 6-OHDA lesion of anteromedial caudate. Pharmacol Biochem Behav 11:23\u201330","journal-title":"Pharmacol Biochem Behav"},{"key":"1744_CR15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0300-483X(88)90029-7","volume":"49","author":"RE Fitzgerald","year":"1988","unstructured":"Fitzgerald RE, Berres M, Schaeppi U (1988) Validation of a photobeam system for assessment of motor activity in rats. Toxicology 49:433\u2013439","journal-title":"Toxicology"},{"key":"1744_CR16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0165-0173(82)90006-6","volume":"257","author":"C Flicker","year":"1982","unstructured":"Flicker C, Geyer MA (1982) Behavior during hippocampal microinfusions. I. Norepinephrine and diversive exploration. Brain Res 257:79\u2013103","journal-title":"Brain Res"},{"key":"1744_CR17","first-page":"326","volume":"31","author":"BN Frey","year":"2006","unstructured":"Frey BN, Valvassori SS, Reus GZ, Martins MR, Petronilho FC, Bardini K, Dal-Pizzol F, Kapczinski F, Quevedo J (2006) Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania. J Psychiatry Neurosci 31:326\u2013332","journal-title":"J Psychiatry Neurosci"},{"key":"1744_CR18","volume-title":"Testing and evaluating drugs of abuse","author":"MA Geyer","year":"1990","unstructured":"Geyer MA (1990) Approaches to the characterization of drug effects on locomotor activity in rodents. In: Adler MW, Cowan A (eds) Testing and evaluating drugs of abuse. Wiley-Liss, New York"},{"key":"1744_CR19","first-page":"445","volume-title":"Neuropsychopharmacology: the fifth generation of progress","author":"MA Geyer","year":"2002","unstructured":"Geyer MA, Markou A (2002) The role of preclinical models in the development of psychotropic drugs. In: Davis KL, Charney D, Coyle JT, Nemeroff C (eds) Neuropsychopharmacology: the fifth generation of progress. Lippincott Williams & Wilkins, Philadelphia, pp 445\u2013455"},{"key":"1744_CR20","first-page":"253","volume-title":"Measuring movement and locomotion: from invertebrates to humans","author":"MA Geyer","year":"1996","unstructured":"Geyer MA, Paulus M (1996) Multivariate analyses of locomotor and investigatory behavior in rodents. In: Ossenkopp KP, Kavaliers M, Sanberg PR (eds) Measuring movement and locomotion: from invertebrates to humans. Landes, Austin, pp 253\u2013271"},{"key":"1744_CR21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0091-3057(86)90266-2","volume":"25","author":"MA Geyer","year":"1986","unstructured":"Geyer MA, Russo PV, Masten VL (1986) Multivariate assessment of locomotor behavior: pharmacological and behavioral analyses. Pharmacol Biochem Behav 25:277\u2013288","journal-title":"Pharmacol Biochem Behav"},{"key":"1744_CR22","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0022-3565(25)13399-5","volume":"247","author":"LH Gold","year":"1988","unstructured":"Gold LH, Koob GF, Geyer MA (1988) Stimulant and hallucinogenic behavioral profiles of 3, 4-methylenedioxymethamphetamine and N-ethyl-3, 4-methylenedioxyamphetamine in rats. J Pharmacol Exp Ther 247:547\u2013555","journal-title":"J Pharmacol Exp Ther"},{"key":"1744_CR23","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.neubiorev.2007.05.007","volume":"31","author":"TD Gould","year":"2007","unstructured":"Gould TD, Einat H (2007) Animal models of bipolar disorder and mood stabilizer efficacy: a critical need for improvement. Neurosci Biobehav Rev 31:825\u2013831","journal-title":"Neurosci Biobehav Rev"},{"key":"1744_CR24","doi-asserted-by":"crossref","unstructured":"Gould TD, O\u2019Donnell KC, Picchini AM, Manji HK (2007) Strain differences in lithium attenuation of d-amphetamine-induced hyperlocomotion: a mouse model for the genetics of clinical response to lithium. Neuropsychopharmacology 32:1321\u20131333","DOI":"10.1038\/sj.npp.1301254"},{"key":"1744_CR25","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0166-4328(00)00318-1","volume":"118","author":"TJ Gould","year":"2001","unstructured":"Gould TJ, Keith RA, Bhat RV (2001) Differential sensitivity to lithium's reversal of amphetamine-induced open-field activity in two inbred strains of mice. Behav Brain Res 118:95\u2013105","journal-title":"Behav Brain Res"},{"key":"1744_CR26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/1096-8628(2001)9999:9999<::AID-AJMG1161>3.0.CO;2-8","volume":"105","author":"TA Greenwood","year":"2001","unstructured":"Greenwood TA, Alexander M, Keck PE, McElroy S, Sadovnick AD, Remick RA, Kelsoe JR (2001) Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder. Am J Med Genet 105:145\u2013151","journal-title":"Am J Med Genet"},{"key":"1744_CR27","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/sj.mp.4001764","volume":"11","author":"TA Greenwood","year":"2006","unstructured":"Greenwood TA, Schork NJ, Eskin E, Kelsoe JR (2006) Identification of additional variants within the human dopamine transporter gene provides further evidence for an association with bipolar disorder in two independent samples. Mol Psychiatry 11:125\u2013133, 115","journal-title":"Mol Psychiatry"},{"key":"1744_CR28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.brainres.2007.03.009","volume":"1151","author":"JM Gulley","year":"2007","unstructured":"Gulley JM, Everett CV, Zahniser NR (2007) Inbred Lewis and Fischer 344 rat strains differ not only in novelty- and amphetamine-induced behaviors, but also in dopamine transporter activity in vivo. Brain Res 1151:32\u201345","journal-title":"Brain Res"},{"key":"1744_CR29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2210-6-6","volume":"6","author":"DD Han","year":"2006","unstructured":"Han DD, Gu HH (2006) Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs. BMC Pharmacol 6:6","journal-title":"BMC Pharmacol"},{"key":"1744_CR30","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0014-2999(84)90483-7","volume":"103","author":"RE Heikkila","year":"1984","unstructured":"Heikkila RE, Manzino L (1984) Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors of dopamine uptake. Eur J Pharmacol 103:241\u2013248","journal-title":"Eur J Pharmacol"},{"key":"1744_CR31","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0006-2952(76)90348-8","volume":"25","author":"JC Holmes","year":"1976","unstructured":"Holmes JC, Rutledge CO (1976) Effects of the d- and l-isomers of amphetamine on uptake, release and catabolism of norepinephrine, dopamine and 5-hydroxytryptamine in several regions of rat brain. Biochem Pharmacol 25:447\u2013451","journal-title":"Biochem Pharmacol"},{"key":"1744_CR32","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/sj.mp.4001730","volume":"10","author":"S Horschitz","year":"2005","unstructured":"Horschitz S, Hummerich R, Lau T, Rietschel M, Schloss P (2005) A dopamine transporter mutation associated with bipolar affective disorder causes inhibition of transporter cell surface expression. Mol Psychiatry 10:1104\u20131109","journal-title":"Mol Psychiatry"},{"key":"1744_CR33","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/jps.2600821120","volume":"82","author":"SH Ingwersen","year":"1993","unstructured":"Ingwersen SH, Snelo S, Mant TGK, Edwards D (1993) Nonlinear multiple-dose pharmacokinetics of the dopamine reuptake inhibitor vanoxerine. J Pharmaceu Sci 82:1164\u20131166","journal-title":"J Pharmaceu Sci"},{"key":"1744_CR34","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.pbb.2009.03.003","volume":"92","author":"MP Kelly","year":"2009","unstructured":"Kelly MP, Logue SF, Dwyer JM, Beyer CE, Majchrowski H, Cai Z, Liu Z, Adedoyin A, Rosenzweig-Lipson S, Comery TA (2009) The supra-additive hyperactivity caused by an amphetamine\u2013chlordiazepoxide mixture exhibits an inverted-U dose response: negative implications for the use of a model in screening for mood stabilizers. Pharmacol Biochem Behav 92:649\u2013654","journal-title":"Pharmacol Biochem Behav"},{"key":"1744_CR35","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/(SICI)1096-8628(19961122)67:6<533::AID-AJMG4>3.0.CO;2-I","volume":"67","author":"JR Kelsoe","year":"1996","unstructured":"Kelsoe JR, Sadovnick AD, Kristbjarnarson H, Bergesch P, Mroczkowski-Parker Z, Drennan M, Rapaport MH, Flodman P, Spence MA, Remick RA (1996) Possible locus for bipolar disorder near the dopamine transporter on chromosome 5. Am J Med Genet 67:533\u2013540","journal-title":"Am J Med Genet"},{"key":"1744_CR36","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/S0028-3908(99)00252-X","volume":"39","author":"JH Kim","year":"2000","unstructured":"Kim JH, Beeler JA, Vezina P (2000) Group II, but not group I, metabotropic glutamate receptors in the rat nucleus accumbens contribute to amphetamine-induced locomotion. Neuropharmacology 39:1692\u20131699","journal-title":"Neuropharmacology"},{"key":"1744_CR37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1460-9568.1997.tb01351.x","volume":"9","author":"V Kitchigina","year":"1997","unstructured":"Kitchigina V, Vankov A, Harley C, Sara SJ (1997) Novelty-elicited, noradrenaline-dependent enhancement of excitability in the dentate gyrus. Eur J NeuroSci 9:41\u201347","journal-title":"Eur J NeuroSci"},{"key":"1744_CR38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.pbb.2006.07.007","volume":"85","author":"CL Kliethermes","year":"2006","unstructured":"Kliethermes CL, Crabbe JC (2006) Pharmacological and genetic influences on hole-board behaviors in mice. Pharmacol Biochem Behav 85:57\u201365","journal-title":"Pharmacol Biochem Behav"},{"key":"1744_CR39","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00432136","volume":"68","author":"L Kokkinidis","year":"1980","unstructured":"Kokkinidis L, Zacharko RM (1980) Intracranial self-stimulation in mice using a modified hole-board task: effects of d-amphetamine. Psychopharmacology (Berl) 68:169\u2013171","journal-title":"Psychopharmacology (Berl)"},{"key":"1744_CR40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1055\/s-0028-1094442","volume":"8","author":"SK Kulkarni","year":"1975","unstructured":"Kulkarni SK, Dandiya PC (1975) Influence of chemical stimulation of central dopaminergic system on the open field behaviour of rats. Pharmakopsychiatr Neuropsychopharmakol 8:45\u201350","journal-title":"Pharmakopsychiatr Neuropsychopharmakol"},{"key":"1744_CR41","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0091-3057(87)90177-8","volume":"26","author":"RG Lister","year":"1987","unstructured":"Lister RG, File SE (1987) The effect of chlordiazepoxide on the habituation of exploration: interactions with the benzodiazepine antagonist RO 15-1788. Pharmacol Biochem Behav 26:631\u2013634","journal-title":"Pharmacol Biochem Behav"},{"key":"1744_CR42","first-page":"136","volume":"2","author":"HK Manji","year":"2003","unstructured":"Manji HK, Quiroz JA, Payne JL, Singh J, Lopes BP, Viegas JS, Zarate CA (2003) The underlying neurobiology of bipolar disorder. World Psychiatry 2:136\u2013146","journal-title":"World Psychiatry"},{"key":"1744_CR43","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1037\/0735-7044.117.3.621","volume":"117","author":"AA Mansour","year":"2003","unstructured":"Mansour AA, Babstock DM, Penney JH, Martin GM, McLean JH, Harley CW (2003) Novel objects in a holeboard probe the role of the locus coeruleus in curiosity: support for two modes of attention in the rat. Behav Neurosci 117:621\u2013631","journal-title":"Behav Neurosci"},{"key":"1744_CR44","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0091-3057(84)80067-2","volume":"21","author":"CJ Meliska","year":"1984","unstructured":"Meliska CJ, Loke WH (1984) Caffeine and nicotine: differential effects on ambulation, rearing and wheelrunning. Pharmacol Biochem Behav 21:871\u2013875","journal-title":"Pharmacol Biochem Behav"},{"key":"1744_CR45","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1001\/archpsyc.64.5.543","volume":"64","author":"KR Merikangas","year":"2007","unstructured":"Merikangas KR, Akiskal HS, Angst J, Greenberg PE, Hirschfeld RM, Petukhova M, Kessler RC (2007) Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry 64:543\u2013552","journal-title":"Arch Gen Psychiatry"},{"key":"1744_CR46","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.biopsych.2006.03.057","volume":"60","author":"HA Mitchell","year":"2006","unstructured":"Mitchell HA, Ahern TH, Liles LC, Javors MA, Weinshenker D (2006) The effects of norepinephrine transporter inactivation on locomotor activity in mice. Biol Psychiatry 60:1046\u20131052","journal-title":"Biol Psychiatry"},{"key":"1744_CR47","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/0278-5846(91)90018-V","volume":"15","author":"MP Paulus","year":"1991","unstructured":"Paulus MP, Geyer MA (1991) A scaling approach to find order parameters quantifying the effects of dopaminergic agents on unconditioned motor activity in rats. Prog Neuropsychopharmacol Biol Psychiatry 15:903\u2013919","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"1744_CR48","first-page":"15","volume":"7","author":"MP Paulus","year":"1992","unstructured":"Paulus MP, Geyer MA (1992) The effects of MDMA and other methylenedioxy-substituted phenylalkylamines on the structure of rat locomotor activity. Neuropsychopharmacology 7:15\u201331","journal-title":"Neuropsychopharmacology"},{"key":"1744_CR49","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0166-4328(05)80262-1","volume":"53","author":"MP Paulus","year":"1993","unstructured":"Paulus MP, Geyer MA (1993) Three independent factors characterize spontaneous rat motor activity. Behav Brain Res 53:11\u201320","journal-title":"Behav Brain Res"},{"key":"1744_CR50","volume-title":"Measuring movement and locomotion: from invertebrate animals to humans","author":"M Paulus","year":"1996","unstructured":"Paulus M, Geyer MA (1996) Assessing the organization of motor behavior: new approaches based on the behavior of complex physical systems. In: Ossenkopp KP, Kavaliers M, Sanberg PR (eds) Measuring movement and locomotion: from invertebrate animals to humans. Chapman & Hall, New York"},{"key":"1744_CR51","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0006-8993(99)01137-3","volume":"835","author":"MP Paulus","year":"1999","unstructured":"Paulus MP, Dulawa SC, Ralph RJ, Geyer MA (1999) Behavioral organization is independent of locomotor activity in 129 and C57 mouse strains. Brain Res 835:27\u201336","journal-title":"Brain Res"},{"issue":"10","key":"1744_CR52","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1001\/archgenpsychiatry.2009.58","volume":"66","author":"W Perry","year":"2009","unstructured":"Perry W, Minassian A, Paulus MP, Young JW, Kincaid MJ, Ferguson EJ, Henry BL, Masten VL, Sharp RF, Geyer MA (2009) A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men. Arch Gen Psychiatry 66(10):1045\u20131054","journal-title":"Arch Gen Psychiatry"},{"key":"1744_CR53","first-page":"241","volume":"1","author":"A Preti","year":"2000","unstructured":"Preti A (2000) Vanoxerine national institute on drug abuse. Curr Op in Invest Drugs 1:241\u2013251","journal-title":"Curr Op in Invest Drugs"},{"key":"1744_CR54","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0006-3223(02)01489-0","volume":"53","author":"RJ Ralph-Williams","year":"2003","unstructured":"Ralph-Williams RJ, Paulus MP, Zhuang X, Hen R, Geyer MA (2003) Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system. Biol Psychiatry 53:352\u2013359","journal-title":"Biol Psychiatry"},{"key":"1744_CR55","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1038\/sj.npp.1301161","volume":"31","author":"VB Risbrough","year":"2006","unstructured":"Risbrough VB, Masten VL, Caldwell S, Paulus MP, Low MJ, Geyer MA (2006) Differential contributions of dopamine D(1), D(2), and D(3) receptors to MDMA-induced effects on locomotor behavior patterns in mice. Neuropsychopharmacology 31:2349\u20132358","journal-title":"Neuropsychopharmacology"},{"key":"1744_CR56","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0166-4328(99)00072-8","volume":"105","author":"DC Rogers","year":"1999","unstructured":"Rogers DC, Jones DN, Nelson PR, Jones CM, Quilter CA, Robinson TL, Hagan JJ (1999) Use of SHIRPA and discriminant analysis to characterise marked differences in the behavioural phenotype of six inbred mouse strains. Behav Brain Res 105:207\u2013217","journal-title":"Behav Brain Res"},{"key":"1744_CR57","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1196\/annals.1369.064","volume":"1074","author":"RB Rothman","year":"2006","unstructured":"Rothman RB, Baumann MH (2006) Balance between dopamine and serotonin release modulates behavioral effects of amphetamine-type drugs. Ann N Y Acad Sci 1074:245\u2013260","journal-title":"Ann N Y Acad Sci"},{"key":"1744_CR58","doi-asserted-by":"crossref","unstructured":"Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA Jr, McClung CA (2007) Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci USA 104:6406\u20136411","DOI":"10.1073\/pnas.0609625104"},{"key":"1744_CR59","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1038\/2111312a0","volume":"211","author":"R Rushton","year":"1966","unstructured":"Rushton R, Steinberg H (1966) Combined effects of chlordiazepoxide and dexamphetamine on activity of rats in an unfamiliar environment. Nature 211:1312\u20131313","journal-title":"Nature"},{"key":"1744_CR60","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0926-6410(95)90007-1","volume":"2","author":"SJ Sara","year":"1995","unstructured":"Sara SJ, Dyon-Laurent C, Herve A (1995) Novelty seeking behavior in the rat is dependent upon the integrity of the noradrenergic system. Brain Res Cogn Brain Res 2:181\u2013187","journal-title":"Brain Res Cogn Brain Res"},{"key":"1744_CR61","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0091-3057(80)90195-1","volume":"12","author":"GR Sessions","year":"1980","unstructured":"Sessions GR, Meyerhoff JL, Kant GJ, Koob GF (1980) Effects of lesions of the ventral medial tegmentum on locomotor activity, biogenic amines and responses to amphetamine in rats. Pharmacol Biochem Behav 12:603\u2013608","journal-title":"Pharmacol Biochem Behav"},{"key":"1744_CR62","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1034\/j.1399-5618.2001.030104.x","volume":"3","author":"A Shaldivin","year":"2001","unstructured":"Shaldivin A, Kaptsan A, Belmaker RH, Einat H, Grisaru N (2001) Transcranial magnetic stimulation in an amphetamine hyperactivity model of mania. Bipolar Disord 3:30\u201334","journal-title":"Bipolar Disord"},{"key":"1744_CR63","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0165-1781(98)00037-7","volume":"79","author":"PH Silverstone","year":"1998","unstructured":"Silverstone PH, Pukhovsky A, Rotzinger S (1998) Lithium does not attenuate the effects of D-amphetamine in healthy volunteers. Psychiatry Res 79:219\u2013226","journal-title":"Psychiatry Res"},{"key":"1744_CR64","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0306-4522(85)90143-5","volume":"14","author":"H Szechtman","year":"1985","unstructured":"Szechtman H, Ornstein K, Teitelbaum P, Golani I (1985) The morphogenesis of stereotyped behavior induced by the dopamine receptor agonist apomorphine in the laboratory rat. Neuroscience 14:783\u2013798","journal-title":"Neuroscience"},{"key":"1744_CR65","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.physbeh.2004.10.017","volume":"84","author":"X Tang","year":"2005","unstructured":"Tang X, Sanford LD (2005) Home cage activity and activity-based measures of anxiety in 129P3\/J, 129X1\/SvJ and C57BL\/6J mice. Physiol Behav 84:105\u2013115","journal-title":"Physiol Behav"},{"key":"1744_CR66","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/BF00518190","volume":"91","author":"AL Vale","year":"1987","unstructured":"Vale AL, Ratcliffe F (1987) Effect of lithium administration on rat brain 5-hydroxyindole levels in a possible animal model for mania. Psychopharmacology (Berl) 91:352\u2013355","journal-title":"Psychopharmacology (Berl)"},{"key":"1744_CR67","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0022-3565(25)24140-4","volume":"248","author":"M Buuse van den","year":"1989","unstructured":"van den Buuse M, de Jong W (1989) Differential effects of dopaminergic drugs on open-field behavior of spontaneously hypertensive rats and normotensive Wistar-Kyoto rats. J Pharmacol Exp Ther 248:1189\u20131196","journal-title":"J Pharmacol Exp Ther"},{"key":"1744_CR68","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0006-3223(00)00978-1","volume":"48","author":"MP Vawter","year":"2000","unstructured":"Vawter MP, Freed WJ, Kleinman JE (2000) Neuropathology of bipolar disorder. Biol Psychiatry 48:486\u2013504","journal-title":"Biol Psychiatry"},{"key":"1744_CR69","doi-asserted-by":"crossref","unstructured":"Yates JW, Meij JT, Sullivan JR, Richtand NM, Yu L (2007) Bimodal effect of amphetamine on C57BL\/6 mice. Neurosci. Lett. 427:66\u201370","DOI":"10.1016\/j.neulet.2007.09.011"},{"key":"1744_CR70","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0006-3223(94)91201-7","volume":"35","author":"LT Young","year":"1994","unstructured":"Young LT, Warsh JJ, Kish SJ, Shannak K, Hornykeiwicz O (1994) Reduced brain 5-HT and elevated NE turnover and metabolites in bipolar affective disorder. Biol Psychiatry 35:121\u2013127","journal-title":"Biol Psychiatry"},{"key":"1744_CR71","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/sj.npp.1300393","volume":"29","author":"JW Young","year":"2004","unstructured":"Young JW, Finlayson K, Spratt C, Marston HM, Crawford N, Kelly JS, Sharkey J (2004) Nicotine improves sustained attention in mice: evidence for involvement of the alpha7 nicotinic acetylcholine receptor. Neuropsychopharmacology 29:891\u2013900","journal-title":"Neuropsychopharmacology"},{"key":"1744_CR72","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.neuropharm.2006.09.006","volume":"52","author":"JW Young","year":"2007","unstructured":"Young JW, Kerr LE, Kelly JS, Marston HM, Spratt C, Finlayson K, Sharkey J (2007a) The odour span task: a novel paradigm for assessing working memory in mice. Neuropharmacology 52:634\u2013645","journal-title":"Neuropharmacology"},{"key":"1744_CR73","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.neubiorev.2007.05.009","volume":"31","author":"JW Young","year":"2007","unstructured":"Young JW, Minassian A, Paulus MP, Geyer MA, Perry W (2007b) A reverse-translational approach to bipolar disorder: rodent and human studies in the behavioral pattern monitor. Neurosci Biobehav Rev 31:882\u2013896","journal-title":"Neurosci Biobehav Rev"},{"key":"1744_CR74","doi-asserted-by":"crossref","first-page":"e4227","DOI":"10.1371\/journal.pone.0004227","volume":"4","author":"JW Young","year":"2009","unstructured":"Young JW, Light GA, Marston HM, Sharp R, Geyer MA (2009a) The 5-choice continuous performance test: evidence for a translational test of vigilance for mice. PLoS ONE 4:e4227","journal-title":"PLoS ONE"},{"key":"1744_CR75","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pharmthera.2009.02.004","volume":"122","author":"JW Young","year":"2009","unstructured":"Young JW, Powell SB, Risbrough V, Marston HM, Geyer MA (2009b) Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia. Pharmacol Ther 122:150\u2013202","journal-title":"Pharmacol Ther"},{"key":"1744_CR76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(01)02090-X","volume":"899","author":"SS Zalcman","year":"2001","unstructured":"Zalcman SS (2001) Interleukin-2 potentiates novelty- and GBR 12909-induced exploratory activity. Brain Res 899:1\u20139","journal-title":"Brain Res"},{"key":"1744_CR77","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1073\/pnas.98.4.1982","volume":"98","author":"X Zhuang","year":"2001","unstructured":"Zhuang X, Oosting RS, Jones SR, Gainetdinov RR, Miller GW, Caron MG, Hen R (2001) Hyperactivity and impaired response habituation in hyperdopaminergic mice. Proc Natl Acad Sci USA 98:1982\u20131987","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s00213-009-1744-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T21:45:59Z","timestamp":1739483159000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-009-1744-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,18]]},"references-count":77,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["1744"],"URL":"https:\/\/doi.org\/10.1007\/s00213-009-1744-8","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,18]]}}}