{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T15:24:41Z","timestamp":1769959481239,"version":"3.49.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,11,12]],"date-time":"2010-11-12T00:00:00Z","timestamp":1289520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2010,11,12]],"date-time":"2010-11-12T00:00:00Z","timestamp":1289520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/s00213-010-2079-1","type":"journal-article","created":{"date-parts":[[2010,11,11]],"date-time":"2010-11-11T05:56:18Z","timestamp":1289454978000},"page":"729-736","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Risk for antipsychotic-induced extrapyramidal symptoms: influence of family history and genetic susceptibility"],"prefix":"10.1007","volume":"214","author":[{"given":"Meike","family":"Kasten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Br\u00fcggemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inke R.","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Doerry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Steinlechner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liv","family":"Wenzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Lohmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebekka","family":"Lencer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,11,12]]},"reference":[{"key":"2079_CR1","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.biopsych.2009.08.036","volume":"67","author":"K Aberg","year":"2010","unstructured":"Aberg K, Adkins DE, Bukszar J, Webb BT, Caroff SN, del Miller D et al (2010) Genomewide association study of movement-related adverse antipsychotic effects. Biol Psychiatry 67:279\u2013282","journal-title":"Biol Psychiatry"},{"key":"2079_CR2","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/YPG.0b013e3283328dcd","volume":"19","author":"I Al-Janabi","year":"2009","unstructured":"Al-Janabi I, Arranz MJ, Blakemore AI, Saiz PA, Susce MT, Glaser PE et al (2009) Association study of serotonergic gene variants with antipsychotic-induced adverse reactions. Psychiatr Genet 19:305\u2013311","journal-title":"Psychiatr Genet"},{"key":"2079_CR3","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00213-009-1627-z","volume":"206","author":"A Alkelai","year":"2009","unstructured":"Alkelai A, Greenbaum L, Rigbi A, Kanyas K, Lerer B (2009) Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients. Psychopharmacology (Berl) 206:491\u2013499","journal-title":"Psychopharmacology (Berl)"},{"key":"2079_CR4","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/sj.mp.4002009","volume":"12","author":"MJ Arranz","year":"2007","unstructured":"Arranz MJ, de Leon J (2007) Pharmacogenetics and pharmacogenomics of schizophrenia: a review of last decade of research. Mol Psychiatry 12:707\u2013747","journal-title":"Mol Psychiatry"},{"key":"2079_CR5","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994","unstructured":"American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric, Washington, DC","edition":"4"},{"key":"2079_CR6","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1001\/jama.1961.03040120016004","volume":"175","author":"FJ Ayd Jr","year":"1961","unstructured":"Ayd FJ Jr (1961) A survey of drug-induced extrapyramidal reactions. Jama 175:1054\u20131060","journal-title":"Jama"},{"key":"2079_CR7","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/sj.mp.4002142","volume":"13","author":"PR Bakker","year":"2008","unstructured":"Bakker PR, van Harten PN, van Os J (2008) Antipsychotic-induced tardive dyskinesia and polymorphic variations in COMT, DRD2, CYP1A2 and MnSOD genes: a meta-analysis of pharmacogenetic interactions. Mol Psychiatry 13:544\u2013556","journal-title":"Mol Psychiatry"},{"key":"2079_CR8","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1002\/1531-8257(199901)14:1<132::AID-MDS1022>3.0.CO;2-J","volume":"14","author":"A Brashear","year":"1999","unstructured":"Brashear A, Mulholland GK, Zheng QH, Farlow MR, Siemers ER, Hutchins GD (1999) PET imaging of the pre-synaptic dopamine uptake sites in rapid-onset dystonia\u2013parkinsonism (RDP). Mov Disord 14:132\u2013137","journal-title":"Mov Disord"},{"key":"2079_CR9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.neuron.2004.06.028","volume":"43","author":"P de Carvalho Aguiar","year":"2004","unstructured":"de Carvalho Aguiar P, Sweadner KJ, Penniston JT, Zaremba J, Liu L, Caton M et al (2004) Mutations in the Na+\/K+-ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism. Neuron 43:169\u2013175","journal-title":"Neuron"},{"key":"2079_CR10","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1093\/brain\/awl355","volume":"130","author":"G Defazio","year":"2007","unstructured":"Defazio G, Berardelli A, Hallett M (2007) Do primary adult-onset focal dystonias share aetiological factors? Brain 130:1183\u20131193","journal-title":"Brain"},{"key":"2079_CR11","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3109\/10401230209147398","volume":"14","author":"J Gerlach","year":"2002","unstructured":"Gerlach J (2002) Improving outcome in schizophrenia: the potential importance of EPS and neuroleptic dysphoria. Ann Clin Psychiatry 14:47\u201357","journal-title":"Ann Clin Psychiatry"},{"key":"2079_CR12","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/S0140-6736(08)60486-9","volume":"371","author":"RS Kahn","year":"2008","unstructured":"Kahn RS, Fleischhacker WW, Boter H, Davidson M, Vergouwe Y, Keet IP et al (2008) Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial. Lancet 371:1085\u20131097","journal-title":"Lancet"},{"key":"2079_CR13","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4088\/JCP.v68n0110","volume":"68","author":"A Karow","year":"2007","unstructured":"Karow A, Czekalla J, Dittmann RW, Schacht A, Wagner T, Lambert M et al (2007) Association of subjective well-being, symptoms, and side effects with compliance after 12\u00a0months of treatment in schizophrenia. J Clin Psychiatry 68:75\u201380","journal-title":"J Clin Psychiatry"},{"key":"2079_CR14","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1093\/nar\/20.5.1164-a","volume":"20","author":"A Kazantsev","year":"1992","unstructured":"Kazantsev A, Yamaoka LH, Roses AD (1992) A dinucleotide repeat polymorphism in the human Na+, K+ ATPase, alpha subunit (ATP1A3) gene. Nucleic Acids Res 20:1164","journal-title":"Nucleic Acids Res"},{"key":"2079_CR15","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3109\/9781420019988.003","volume-title":"Handbook of dystonia","author":"C Klein","year":"2006","unstructured":"Klein C, Ozelius L, Breakefield XO (2006) Genetic evaluation in primary dystonia. In: Stacy M (ed) Handbook of dystonia. Taylor and Francis Group, New York, pp 21\u201344"},{"key":"2079_CR16","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.psychres.2007.08.002","volume":"161","author":"A Lafuente","year":"2008","unstructured":"Lafuente A, Bernardo M, Mas S, Crescenti A, Aparici M, Gasso P et al (2008) Polymorphism of dopamine D2 receptor (TaqIA, TaqIB, and-141\u00a0C Ins\/Del) and dopamine degradation enzyme (COMT G158A, A-278\u00a0G) genes and extrapyramidal symptoms in patients with schizophrenia and bipolar disorders. Psychiatry Res 161:131\u2013141","journal-title":"Psychiatry Res"},{"key":"2079_CR17","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1192\/bjp.185.6.465","volume":"185","author":"R Lencer","year":"2004","unstructured":"Lencer R, Eismann G, Kasten M, Kabakci K, Geithe V, Grimm J et al (2004) Family history of primary movement disorders as a predictor for neuroleptic-induced extrapyramidal symptoms. Br J Psychiatry 185:465\u2013471","journal-title":"Br J Psychiatry"},{"key":"2079_CR18","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1056\/NEJMoa051688","volume":"353","author":"JA Lieberman","year":"2005","unstructured":"Lieberman JA, Stroup TS, McEvoy JP, Swartz MS, Rosenheck RA, Perkins DO et al (2005) Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 353:1209\u20131223","journal-title":"N Engl J Med"},{"key":"2079_CR19","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0006-3223(97)00343-0","volume":"44","author":"L Mynett-Johnson","year":"1998","unstructured":"Mynett-Johnson L, Murphy V, McCormack J, Shields DC, Claffey E, Manley P et al (1998) Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3). Biol Psychiatry 44:47\u201351","journal-title":"Biol Psychiatry"},{"key":"2079_CR20","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1176\/ajp.145.11.1455","volume":"145","author":"HA Nasrallah","year":"1988","unstructured":"Nasrallah HA, Churchill CM, Hamdan-Allan GA (1988) Higher frequency of neuroleptic-induced dystonia in mania than in schizophrenia. Am J Psychiatry 145:1455\u20131456","journal-title":"Am J Psychiatry"},{"key":"2079_CR21","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.4088\/JCP.v63n1206","volume":"63","author":"DO Perkins","year":"2002","unstructured":"Perkins DO (2002) Predictors of noncompliance in patients with schizophrenia. J Clin Psychiatry 63:1121\u20131128","journal-title":"J Clin Psychiatry"},{"key":"2079_CR22","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/ajmg.1322","volume":"105","author":"RA Philibert","year":"2001","unstructured":"Philibert RA, Cheung D, Welsh N, Damschroder-Williams P, Thiel B, Ginns EI et al (2001) Absence of a significant linkage between Na(+), K(+)-ATPase subunit (ATP1A3 and ATP1B3) genotypes and bipolar affective disorder in the old-order Amish. Am J Med Genet 105:291\u2013294","journal-title":"Am J Med Genet"},{"key":"2079_CR23","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1212\/WNL.55.7.991","volume":"55","author":"SJ Pittock","year":"2000","unstructured":"Pittock SJ, Joyce C, O\u2019Keane V, Hugle B, Hardiman MO, Brett F et al (2000) Rapid-onset dystonia\u2013parkinsonism: a clinical and genetic analysis of a new kindred. Neurology 55:991\u2013995","journal-title":"Neurology"},{"key":"2079_CR24","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0920-9964(00)00008-6","volume":"47","author":"TN Srinivasan","year":"2001","unstructured":"Srinivasan TN, Thara R, Padmavathi R, McCreadie RG (2001) Relationship of extrapyramidal symptoms to age at onset and drug treatment in middle-aged and elderly schizophrenic patients. Schizophr Res 47:69\u201375","journal-title":"Schizophr Res"},{"key":"2079_CR25","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1176\/ajp.132.5.532","volume":"132","author":"C Swett Jr","year":"1975","unstructured":"Swett C Jr (1975) Drug-induced dystonia. Am J Psychiatry 132:532\u2013534","journal-title":"Am J Psychiatry"},{"issue":"Suppl 7","key":"2079_CR26","doi-asserted-by":"publisher","first-page":"S28","DOI":"10.1002\/mds.10575","volume":"18","author":"E Tolosa","year":"2003","unstructured":"Tolosa E, Coelho M, Gallardo M (2003) DAT imaging in drug-induced and psychogenic parkinsonism. Mov Disord 18(Suppl 7):S28\u2013S33","journal-title":"Mov Disord"},{"key":"2079_CR27","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1093\/brain\/124.6.1077","volume":"124","author":"P Vuilleumier","year":"2001","unstructured":"Vuilleumier P, Chicherio C, Assal F, Schwartz S, Slosman D, Landis T (2001) Functional neuroanatomical correlates of hysterical sensorimotor loss. Brain 124:1077\u20131090","journal-title":"Brain"},{"key":"2079_CR28","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/00131746-200701000-00003","volume":"13","author":"PJ Weiden","year":"2007","unstructured":"Weiden PJ (2007) EPS profiles: the atypical antipsychotics are not all the same. J Psychiatr Pract 13:13\u201324","journal-title":"J Psychiatr Pract"},{"key":"2079_CR29","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1080\/13554790802613033","volume":"15","author":"MS Won","year":"2008","unstructured":"Won MS, Mikos A, Hurd M, Fernandez H, Eskin T, Romrell J et al (2008) Tardive parkinsonism in a bipolar patient: post-mortem examination supports a physiological rather than pathological dysfunction. Neurocase 15:66\u201369","journal-title":"Neurocase"},{"issue":"9","key":"2079_CR30","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1038\/sj.mp.4002023","volume":"12","author":"CC Zai","year":"2007","unstructured":"Zai CC, De Luca V, Hwang RW, Voineskos A, M\u00fcller DJ, Remington G et al (2007) Meta-analysis of two dopamine D2 receptor gene polymorphisms with tardive dyskinesia in schizophrenia patients. Mol Psychiatry 12(9):794\u2013795","journal-title":"Mol Psychiatry"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-010-2079-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-010-2079-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-010-2079-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-010-2079-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T05:52:59Z","timestamp":1736920379000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-010-2079-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,12]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["2079"],"URL":"https:\/\/doi.org\/10.1007\/s00213-010-2079-1","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,12]]},"assertion":[{"value":"26 July 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}