{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:54:45Z","timestamp":1789736085433,"version":"4.0.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s00213-011-2356-7","type":"journal-article","created":{"date-parts":[[2011,6,6]],"date-time":"2011-06-06T05:20:56Z","timestamp":1307337656000},"page":"621-634","source":"Crossref","is-referenced-by-count":24,"title":["Antidepressant-like properties of sarizotan in experimental Parkinsonism"],"prefix":"10.1007","volume":"218","author":[{"given":"Xiaoqun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Egeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Svenningsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,6,7]]},"reference":[{"key":"2356_CR1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/sj.npp.1300320","volume":"29","author":"M Banasr","year":"2004","unstructured":"Banasr M, Hery M, Printemps R, Daszuta A (2004) Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone. Neuropsychopharmacology 29:450\u2013460","journal-title":"Neuropsychopharmacology"},{"key":"2356_CR2","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/mds.20370","volume":"20","author":"W Bara-Jimenez","year":"2005","unstructured":"Bara-Jimenez W, Bibbiani F, Morris MJ, Dimitrova T, Sherzai A, Mouradian MM, Chase TN (2005) Effects of serotonin 5-HT1A agonist in advanced Parkinson's disease. Mov Disord 20:932\u2013936","journal-title":"Mov Disord"},{"key":"2356_CR3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00702-003-0094-7","volume":"111","author":"GD Bartoszyk","year":"2004","unstructured":"Bartoszyk GD, Van Amsterdam C, Greiner HE, Rautenberg W, Russ H, Seyfried CA (2004) Sarizotan, a serotonin 5-HT1A receptor agonist and dopamine receptor ligand. 1. Neurochemical profile. J Neural Transm 111:113\u2013126","journal-title":"J Neural Transm"},{"key":"2356_CR4","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1212\/WNL.57.10.1829","volume":"57","author":"F Bibbiani","year":"2001","unstructured":"Bibbiani F, Oh JD, Chase TN (2001) Serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models. Neurology 57:1829\u20131834","journal-title":"Neurology"},{"key":"2356_CR5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/FBP.0b013e3282f62cb2","volume":"19","author":"LA Bruins Slot","year":"2008","unstructured":"Bruins Slot LA, Bardin L, Auclair AL, Depoortere R, Newman-Tancredi A (2008) Effects of antipsychotics and reference monoaminergic ligands on marble burying behavior in mice. Behav Pharmacol 19:145\u2013152","journal-title":"Behav Pharmacol"},{"key":"2356_CR6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1474-4422(06)70373-8","volume":"5","author":"KR Chaudhuri","year":"2006","unstructured":"Chaudhuri KR, Healy DG, Schapira AH (2006) Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol 5:235\u2013245","journal-title":"Lancet Neurol"},{"key":"2356_CR7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0160-5402(91)90002-M","volume":"25","author":"E Ericson","year":"1991","unstructured":"Ericson E, Samuelsson J, Ahlenius S (1991) Photocell measurements of rat motor activity. A contribution to sensitivity and variation in behavioral observations. J Pharmacol Methods 25:111\u2013122","journal-title":"J Pharmacol Methods"},{"key":"2356_CR8","unstructured":"Gerlach M, Bartoszyk GD, Riederer P, Dean O, van den Buuse M (2011) Role of dopamine D(3) and serotonin 5-HT (1A) receptors in l-DOPA-induced dyskinesias and effects of sarizotan in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease. J Neural Transm. PMID:21253782"},{"key":"2356_CR9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/mds.21226","volume":"22","author":"CG Goetz","year":"2007","unstructured":"Goetz CG, Damier P, Hicking C, Laska E, Muller T, Olanow CW, Rascol O, Russ H (2007) Sarizotan as a treatment for dyskinesias in Parkinson's disease: a double-blind placebo-controlled trial. Mov Disord 22:179\u2013186","journal-title":"Mov Disord"},{"key":"2356_CR10","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nn1265","volume":"7","author":"GU Hoglinger","year":"2004","unstructured":"Hoglinger GU, Rizk P, Muriel MP, Duyckaerts C, Oertel WH, Caille I, Hirsch EC (2004) Dopamine depletion impairs precursor cell proliferation in Parkinson's disease. Nat Neurosci 7:726\u2013735","journal-title":"Nat Neurosci"},{"key":"2356_CR11","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1523\/JNEUROSCI.1120-05.2005","volume":"25","author":"TE Kippin","year":"2005","unstructured":"Kippin TE, Kapur S, van der Kooy D (2005) Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs. J Neurosci 25:5815\u20135823","journal-title":"J Neurosci"},{"key":"2356_CR12","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00008877-199711000-00010","volume":"8","author":"I Lucki","year":"1997","unstructured":"Lucki I (1997) The forced swimming test as a model for core and component behavioral effects of antidepressant drugs. Behav Pharmacol 8:523\u2013532","journal-title":"Behav Pharmacol"},{"key":"2356_CR13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.nbd.2004.01.007","volume":"16","author":"M Lundblad","year":"2004","unstructured":"Lundblad M, Picconi B, Lindgren H, Cenci MA (2004) A model of l-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: relation to motor and cellular parameters of nigrostriatal function. Neurobiol Dis 16:110\u2013123","journal-title":"Neurobiol Dis"},{"key":"2356_CR14","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000","volume":"20","author":"JE Malberg","year":"2000","unstructured":"Malberg JE, Eisch AJ, Nestler EJ, Duman RS (2000) Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 20:9104\u20139110","journal-title":"J Neurosci"},{"key":"2356_CR15","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2165\/00023210-200721090-00002","volume":"21","author":"SS Newton","year":"2007","unstructured":"Newton SS, Duman RS (2007) Neurogenic actions of atypical antipsychotic drugs and therapeutic implications. CNS Drugs 21:715\u2013725","journal-title":"CNS Drugs"},{"key":"2356_CR16","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s00415-009-5353-6","volume":"257","author":"S P\u00e5lhagen","year":"2010","unstructured":"P\u00e5lhagen S, Qi H, M\u00e5rtensson B, W\u00e5linder J, Gran\u00e9rus AK, Svenningsson P (2010) Monoamines, BDNF, IL-6 and corticosterone in CSF in patients with Parkinson's disease and major depression. J Neurol 257:524\u2013532","journal-title":"J Neurol"},{"key":"2356_CR17","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","volume":"266","author":"RD Porsolt","year":"1977","unstructured":"Porsolt RD, Le Pichon M, Jalfre M (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266:730\u2013732","journal-title":"Nature"},{"key":"2356_CR18","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0006-8993(02)03477-7","volume":"955","author":"JJ Radley","year":"2002","unstructured":"Radley JJ, Jacobs BL (2002) 5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus. Brain Res 955:264\u2013267","journal-title":"Brain Res"},{"key":"2356_CR19","doi-asserted-by":"crossref","first-page":"14476","DOI":"10.1073\/pnas.95.24.14476","volume":"95","author":"S Ramboz","year":"1998","unstructured":"Ramboz S, Oosting R, Amara DA, Kung HF, Blier P, Mendelsohn M, Mann JJ, Brunner D, Hen R (1998) Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc Natl Acad Sci USA 95:14476\u201314481","journal-title":"Proc Natl Acad Sci USA"},{"key":"2356_CR20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/mds.21803","volume":"23","author":"JS Reijnders","year":"2008","unstructured":"Reijnders JS, Ehrt U, Weber WE, Aarsland D, Leentjens AF (2008) A systematic review of prevalence studies of depression in Parkinson's disease. Mov Disord 23:183\u2013189, quiz 313","journal-title":"Mov Disord"},{"key":"2356_CR21","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/nn1969","volume":"10","author":"A Sahay","year":"2007","unstructured":"Sahay A, Hen R (2007) Adult hippocampal neurogenesis in depression. Nat Neurosci 10:1110\u20131115","journal-title":"Nat Neurosci"},{"key":"2356_CR22","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","volume":"301","author":"L Santarelli","year":"2003","unstructured":"Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805\u2013809","journal-title":"Science"},{"key":"2356_CR23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pneurobio.2009.01.009","volume":"88","author":"J Savitz","year":"2009","unstructured":"Savitz J, Lucki I, Drevets WC (2009) 5-HT(1A) receptor function in major depressive disorder. Prog Neurobiol 88:17\u201331","journal-title":"Prog Neurobiol"},{"key":"2356_CR24","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","volume":"182","author":"T Scholzen","year":"2000","unstructured":"Scholzen T, Gerdes J (2000) The Ki-67 protein: from the known and the unknown. J Cell Physiol 182:311\u2013322","journal-title":"J Cell Physiol"},{"key":"2356_CR25","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1523\/JNEUROSCI.3574-07.2008","volume":"28","author":"P Yang","year":"2008","unstructured":"Yang P, Arnold SA, Habas A, Hetman M, Hagg T (2008) Ciliary neurotrophic factor mediates dopamine D2 receptor-induced CNS neurogenesis in adult mice. J Neurosci 28:2231\u20132241","journal-title":"J Neurosci"},{"key":"2356_CR26","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1073\/pnas.0711839105","volume":"105","author":"X Zhang","year":"2008","unstructured":"Zhang X, Andren PE, Greengard P, Svenningsson P (2008) Evidence for a role of the 5-HT1B receptor and its adaptor protein, p11, in l-DOPA treatment of an animal model of Parkinsonism. Proc Natl Acad Sci USA 105:2163\u20132168","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s00213-011-2356-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T12:35:34Z","timestamp":1560256534000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-011-2356-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,7]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["2356"],"URL":"https:\/\/doi.org\/10.1007\/s00213-011-2356-7","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,7]]}}}