{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:19:47Z","timestamp":1792153187315,"version":"4.4.0"},"reference-count":115,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T00:00:00Z","timestamp":1326240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1007\/s00213-011-2555-2","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T06:30:24Z","timestamp":1326177024000},"page":"155-169","source":"Crossref","is-referenced-by-count":258,"title":["Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters"],"prefix":"10.1007","volume":"221","author":[{"given":"Kieran J.","family":"Davey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhain M.","family":"O\u2019Mahony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Schellekens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orla","family":"O\u2019Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Bienenstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Cotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy G.","family":"Dinan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Cryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,1,11]]},"reference":[{"key":"2555_CR1","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.jpsychires.2008.01.004","volume":"42","author":"M Ader","year":"2008","unstructured":"Ader M, Garvey WT, Phillips LS, Nemeroff CB, Gharabawi G, Mahmoud R, Greenspan A, Berry SA, Musselman DL, Morein J, Zhu Y, Mao L, Bergman RN (2008) Ethnic heterogeneity in glucoregulatory function during treatment with atypical antipsychotics in patients with schizophrenia. J Psychiatr Res 42:1076\u201385","journal-title":"J Psychiatr Res"},{"key":"2555_CR2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1744-859X-7-12","volume":"7","author":"S Ahmer","year":"2008","unstructured":"Ahmer S, Khan RA, Iqbal SP (2008) Association between antipsychotics and weight gain among psychiatric outpatients in Pakistan: a retrospective cohort study. Ann Gen Psychiatry 7:12","journal-title":"Ann Gen Psychiatry"},{"key":"2555_CR3","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00115-006-2112-0","volume":"78","author":"W Aichhorn","year":"2007","unstructured":"Aichhorn W, Whitworth AB, Weiss EM, Hinterhuber H, Marksteiner J (2007) Differences between men and women in side effects of second-generation antipsychotics. Nervenarzt 78:45\u201352","journal-title":"Nervenarzt"},{"key":"2555_CR4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/oby.2006.6","volume":"14","author":"VL Albaugh","year":"2006","unstructured":"Albaugh VL, Henry CR, Bello NT, Hajnal A, Lynch SL, Halle B, Lynch CJ (2006) Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents. Obesity (Silver Spring) 14:36\u201351","journal-title":"Obesity (Silver Spring)"},{"key":"2555_CR5","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/mp.2010.33","volume":"16","author":"VL Albaugh","year":"2011","unstructured":"Albaugh VL, Judson JG, She P, Lang CH, Maresca KP, Joyal JL, Lynch CJ (2011) Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis. Mol Psychiatry 16:569\u2013581","journal-title":"Mol Psychiatry"},{"key":"2555_CR6","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","author":"SF Altschul","year":"1997","unstructured":"Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25:3389\u2013402","journal-title":"Nucleic Acids Res"},{"key":"2555_CR7","doi-asserted-by":"crossref","first-page":"15718","DOI":"10.1073\/pnas.0407076101","volume":"101","author":"F Backhed","year":"2004","unstructured":"Backhed F, Ding H, Wang T, Hooper LV, Koh GY, Nagy A, Semenkovich CF, Gordon JI (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 101:15718\u201315723","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2555_CR8","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1073\/pnas.0605374104","volume":"104","author":"F Backhed","year":"2007","unstructured":"Backhed F, Manchester JK, Semenkovich CF, Gordon JI (2007) Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A 104:979\u2013984","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2555_CR9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bbi.2010.10.023","volume":"25","author":"MT Bailey","year":"2011","unstructured":"Bailey MT, Dowd SE, Galley JD, Hufnagle AR, Allen RG, Lyte M (2011) Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation. Brain Behav Immun 25:397\u2013407","journal-title":"Brain Behav Immun"},{"key":"2555_CR10","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.4049\/jimmunol.168.10.5369","volume":"168","author":"M Bao","year":"2002","unstructured":"Bao M, Yang Y, Jun HS, Yoon JW (2002) Molecular mechanisms for gender differences in susceptibility to T cell-mediated autoimmune diabetes in nonobese diabetic mice. J Immunol 168:5369\u20135375","journal-title":"J Immunol"},{"key":"2555_CR11","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1177\/070674370204700805","volume":"47","author":"T Baptista","year":"2002","unstructured":"Baptista T, Beaulieu S (2002) Are leptin and cytokines involved in body weight gain during treatment with antipsychotic drugs? Can J Psychiatry 47:742\u20139","journal-title":"Can J Psychiatry"},{"key":"2555_CR12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4088\/JCP.v62n0404","volume":"62","author":"BR Basson","year":"2001","unstructured":"Basson BR, Kinon BJ, Taylor CC, Szymanski KA, Gilmore JA, Tollefson GD (2001) Factors influencing acute weight change in patients with schizophrenia treated with olanzapine, haloperidol, or risperidone. J Clin Psychiatry 62:231\u2013238","journal-title":"J Clin Psychiatry"},{"key":"2555_CR13","first-page":"4","volume":"17","author":"JP Bastard","year":"2006","unstructured":"Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B (2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17:4\u201312","journal-title":"Eur Cytokine Netw"},{"key":"2555_CR14","first-page":"529","volume":"37","author":"I Beierle","year":"1999","unstructured":"Beierle I, Meibohm B, Derendorf H (1999) Gender differences in pharmacokinetics and pharmacodynamics. Int J Clin Pharmacol Ther 37:529\u2013547","journal-title":"Int J Clin Pharmacol Ther"},{"key":"2555_CR15","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/JCP.0b013e318166c4f7","volume":"28","author":"AB Birkenaes","year":"2008","unstructured":"Birkenaes AB, Birkeland KI, Engh JA, Faerden A, Jonsdottir H, Ringen PA, Friis S, Opjordsmoen S, Andreassen OA (2008) Dyslipidemia independent of body mass in antipsychotic-treated patients under real-life conditions. J Clin Psychopharmacol 28:132\u20137","journal-title":"J Clin Psychopharmacol"},{"key":"2555_CR16","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.2337\/diacare.14.12.1132","volume":"14","author":"P Bjorntorp","year":"1991","unstructured":"Bjorntorp P (1991) Metabolic implications of body-fat distribution. Diabetes Care 14:1132\u20131143","journal-title":"Diabetes Care"},{"key":"2555_CR17","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.tips.2010.07.002","volume":"31","author":"HN Boyda","year":"2010","unstructured":"Boyda HN, Tse L, Procyshyn RM, Honer WG, Barr AM (2010) Preclinical models of antipsychotic drug-induced metabolic side effects. Trends Pharmacol Sci 31:484\u2013497","journal-title":"Trends Pharmacol Sci"},{"key":"2555_CR18","doi-asserted-by":"crossref","unstructured":"Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF (2011) Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci USA 108(38):16050\u201316055","DOI":"10.1073\/pnas.1102999108"},{"key":"2555_CR19","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1007\/s00125-007-0791-0","volume":"50","author":"PD Cani","year":"2007","unstructured":"Cani PD, Neyrinck AM, Fava F, Knauf C, Burcelin RG, Tuohy KM, Gibson GR, Delzenne NM (2007) Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 50:2374\u20132383","journal-title":"Diabetologia"},{"key":"2555_CR20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-3956(96)00055-6","volume":"31","author":"JG Cannon","year":"1997","unstructured":"Cannon JG, Pierre BAS (1997) Gender differences in host defense mechanisms. J Psychiatr Res 31:99\u2013113","journal-title":"J Psychiatr Res"},{"key":"2555_CR21","first-page":"1039","volume":"148","author":"L Chedid","year":"1954","unstructured":"Chedid L (1954) *Actions Comparees De La Promethazine, De La Chlorpromazine Et De La Cortisone Chez La Souris Recevant Des Doses Mortelles Dune Endotoxine Bacterienne. Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales 148:1039\u20131043","journal-title":"Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales"},{"key":"2555_CR22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.schres.2008.06.006","volume":"104","author":"AF Chintoh","year":"2008","unstructured":"Chintoh AF, Mann SW, Lam TK, Giacca A, Remington G (2008) Insulin resistance following continuous, chronic olanzapine treatment: an animal model. Schizophr Res 104:23\u201330","journal-title":"Schizophr Res"},{"key":"2555_CR23","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.lfs.2007.08.009","volume":"81","author":"S Choi","year":"2007","unstructured":"Choi S, DiSilvio B, Unangst J, Fernstrom JD (2007) Effect of chronic infusion of olanzapine and clozapine on food intake and body weight gain in male and female rats. Life Sci 81:1024\u201330","journal-title":"Life Sci"},{"key":"2555_CR24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2165\/11589060-000000000-00000","volume":"31","author":"L Citrome","year":"2011","unstructured":"Citrome L, Holt RIG, Walker DJ, Hoffmann VP (2011) Weight gain and changes in metabolic variables following olanzapine treatment in schizophrenia and bipolar disorder. Clin Drug Invest 31:455\u2013482. doi: 10.2165\/11589060-000000000-00000","journal-title":"Clin Drug Invest"},{"key":"2555_CR25","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/JCP.0b013e3181a289cb","volume":"29","author":"L Citrome","year":"2009","unstructured":"Citrome L, Stauffer VL, Chen L, Kinon BJ, Kurtz DL, Jacobson JG, Bergstrom RF (2009) Olanzapine plasma concentrations after treatment with 10, 20, and 40\u00a0mg\/d in patients with schizophrenia: an analysis of correlations with efficacy, weight gain, and prolactin concentration. J Clin Psychopharmacol 29:278\u2013283","journal-title":"J Clin Psychopharmacol"},{"key":"2555_CR26","doi-asserted-by":"crossref","unstructured":"Claesson MJ, O\u2019Sullivan O, Wang Q, Nikkila J, Marchesi JR, Smidt H, de Vos WM, Ross RP, O\u2019Toole PW (2009) Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine. 4:e6669","DOI":"10.1371\/journal.pone.0006669"},{"key":"2555_CR27","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nm.2087","volume":"16","author":"TB Clarke","year":"2010","unstructured":"Clarke TB, Davis KM, Lysenko ES, Zhou AY, Yu YM, Weiser JN (2010) Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med 16:228\u2013U137","journal-title":"Nat Med"},{"key":"2555_CR28","doi-asserted-by":"crossref","first-page":"765","DOI":"10.4088\/JCP.09ac05255","volume":"70","author":"D Cohen","year":"2009","unstructured":"Cohen D, Correll CU (2009) Second-generation antipsychotic-associated diabetes mellitus and diabetic ketoacidosis: mechanisms, predictors, and screening need. J Clin Psychiatry 70:765\u20136","journal-title":"J Clin Psychiatry"},{"key":"2555_CR29","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.pnpbp.2007.09.012","volume":"32","author":"GD Cooper","year":"2008","unstructured":"Cooper GD, Harrold JA, Halford JCG, Goudie AJ (2008) Chronic clozapine treatment in female rats does not induce weight gain or metabolic abnormalities but enhances adiposity: implications for animal models of antipsychotic-induced weight gain. Prog Neuropsychopharmacology Biol Psychiatry 32:428\u2013436","journal-title":"Prog Neuropsychopharmacology Biol Psychiatry"},{"key":"2555_CR30","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s00213-005-2224-4","volume":"181","author":"GD Cooper","year":"2005","unstructured":"Cooper GD, Pickavance LC, Wilding JP, Halford JC, Goudie AJ (2005) A parametric analysis of olanzapine-induced weight gain in female rats. Psychopharmacology (Berl) 181:80\u20139","journal-title":"Psychopharmacology (Berl)"},{"key":"2555_CR31","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1001\/jama.2009.1549","volume":"302","author":"CU Correll","year":"2009","unstructured":"Correll CU, Manu P, Olshanskiy V, Napolitano B, Kane JM, Malhotra AK (2009) Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents. JAMA 302:1765\u201373","journal-title":"JAMA"},{"key":"2555_CR32","doi-asserted-by":"crossref","unstructured":"Cryan JF, O\u2019Mahony SM (2011) The microbiome-gut-brain axis: from bowel to behavior. Neurogastroenterology and Motility 23(3):187\u2013192","DOI":"10.1111\/j.1365-2982.2010.01664.x"},{"key":"2555_CR33","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.2337\/diabetes.50.8.1714","volume":"50","author":"DE Cummings","year":"2001","unstructured":"Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS (2001) A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50:1714\u20131719","journal-title":"Diabetes"},{"key":"2555_CR34","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0899-9007(01)00672-4","volume":"17","author":"UN Das","year":"2001","unstructured":"Das UN (2001) Is obesity an inflammatory condition? Nutrition 17:953\u2013966","journal-title":"Nutrition"},{"key":"2555_CR35","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1365-2710.2006.00784.x","volume":"31","author":"IR Oliveira De","year":"2006","unstructured":"De Oliveira IR, Juruena MF (2006) Treatment of psychosis: 30\u00a0years of progress. J Clin Pharm Ther 31:523\u2013534","journal-title":"J Clin Pharm Ther"},{"key":"2555_CR36","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.3945\/ajcn.2008.26546","volume":"88","author":"EW Demerath","year":"2008","unstructured":"Demerath EW, Reed D, Rogers N, Sun SS, Lee M, Choh AC, Couch W, Czerwinski SA, Chumlea WC, Siervogel RM, Towne B (2008) Visceral adiposity and its anatomical distribution as predictors of the metabolic syndrome and cardiometabolic risk factor levels. Am J Clin Nutr 88:1263\u201371","journal-title":"Am J Clin Nutr"},{"key":"2555_CR37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pnpbp.2009.11.009","volume":"34","author":"C Deng","year":"2010","unstructured":"Deng C, Weston-Green K, Huang XF (2010) The role of histaminergic H1 and H3 receptors in food intake: a mechanism for atypical antipsychotic-induced weight gain? Prog Neuropsychopharmacol Biol Psychiatry 34:1\u20134","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2555_CR38","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/j.1525-1497.2004.40126.x","volume":"19","author":"WR Farwell","year":"2004","unstructured":"Farwell WR, Stump TE, Wang J, Tafesse E, L'Italien G, Tierney WM (2004) Weight gain and new onset diabetes associated with olanzapine and risperidone. J Gen Intern Med 19:1200\u20135","journal-title":"J Gen Intern Med"},{"key":"2555_CR39","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00213-005-0131-3","volume":"182","author":"M Fell","year":"2005","unstructured":"Fell M, Neill J, Rao C, Marshall K (2005) Effects of sub-chronic antipsychotic drug treatment on body weight and reproductive function in juvenile female rats. Psychopharmacology 182:499\u2013507","journal-title":"Psychopharmacology"},{"key":"2555_CR40","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2202-7-69","volume":"7","author":"J Ferno","year":"2006","unstructured":"Ferno J, Skrede S, Vik-Mo AO, Havik B, Steen VM (2006) Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs. BMC Neurosci 7:69","journal-title":"BMC Neurosci"},{"key":"2555_CR41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2741\/3675","volume":"16","author":"J Ferno","year":"2011","unstructured":"Ferno J, Skrede S, Vik-Mo AO, Jassim G, Le Hellard S, Steen VM (2011) Lipogenic effects of psychotropic drugs: focus on the SREBP system. Front Biosci (Landmark) 16:49\u201360","journal-title":"Front Biosci (Landmark)"},{"key":"2555_CR42","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00213-008-1370-x","volume":"203","author":"J Ferno","year":"2009","unstructured":"Ferno J, Vik-Mo AO, Jassim G, Havik B, Berge K, Skrede S, Gudbrandsen OA, Waage J, Lunder N, Mork S, Berge RK, Jorgensen HA, Steen VM (2009) Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver. Psychopharmacology (Berl) 203:73\u201384","journal-title":"Psychopharmacology (Berl)"},{"key":"2555_CR43","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000100426","volume":"68","author":"P Ferre","year":"2007","unstructured":"Ferre P, Foufelle F (2007) SREBP-1c transcription factor and lipid homeostasis: clinical perspective. Horm Res 68:72\u201382","journal-title":"Horm Res"},{"key":"2555_CR44","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrmicro1817","volume":"6","author":"HJ Flint","year":"2008","unstructured":"Flint HJ, Bayer EA, Rincon MT, Lamed R, White BA (2008) Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis. Nat Rev Microbiol 6:121\u2013131","journal-title":"Nat Rev Microbiol"},{"key":"2555_CR45","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1038\/oby.2010.6","volume":"18","author":"RJ Fountaine","year":"2010","unstructured":"Fountaine RJ, Taylor AE, Mancuso JP, Greenway FL, Byerley LO, Smith SR, Most MM, Fryburg DA (2010) Increased food intake and energy expenditure following administration of olanzapine to healthy men. Obesity 18:1646\u20131651","journal-title":"Obesity"},{"key":"2555_CR46","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1538\/expanim.57.489","volume":"57","author":"S Fushuku","year":"2008","unstructured":"Fushuku S, Fukuda K (2008) Gender difference in the composition of fecal flora in laboratory mice, as detected by denaturing gradient gel electrophoresis (DGGE). Exp Anim 57:489\u2013493","journal-title":"Exp Anim"},{"key":"2555_CR47","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jpsychires.2008.11.001","volume":"43","author":"S Gebhardt","year":"2009","unstructured":"Gebhardt S, Haberhausen M, Heinzel-Gutenbrunner M, Gebhardt N, Remschmidt H, Krieg J-C, Hebebrand J, Theisen FM (2009) Antipsychotic-induced body weight gain: predictors and a systematic categorization of the long-term weight course. J Psychiatr Res 43:620\u2013626","journal-title":"J Psychiatr Res"},{"key":"2555_CR48","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1365-2265.2004.01993.x","volume":"60","author":"Y Greenman","year":"2004","unstructured":"Greenman Y, Golani N, Gilad S, Yaron M, Limor R, Stern N (2004) Ghrelin secretion is modulated in a nutrient- and gender-specific manner. Clin Endocrinol 60:382\u2013388","journal-title":"Clin Endocrinol"},{"key":"2555_CR49","doi-asserted-by":"crossref","unstructured":"Haack S, Seeringer A, Th\u00c3\u00bcrmann PA, Becker T, Kirchheiner J (2009) Sex-specific differences in side effects of psychotropic drugs: genes or gender?, pp 1511\u20131526","DOI":"10.2217\/pgs.09.102"},{"key":"2555_CR50","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.schres.2006.03.020","volume":"84","author":"H Hakko","year":"2006","unstructured":"Hakko H, Komulainen MT, Koponen H, Saari K, Laitinen J, J\u00e4rvelin M-R, Lindeman S (2006) Are females at special risk of obesity if they become psychotic? The longitudinal Northern Finland 1966 Birth Cohort Study. Schizophr Res 84:15\u201319","journal-title":"Schizophr Res"},{"key":"2555_CR51","doi-asserted-by":"crossref","first-page":"222","DOI":"10.2165\/00003495-199550020-00003","volume":"50","author":"RZ Harris","year":"1995","unstructured":"Harris RZ, Benet LZ, Schwartz JB (1995) Gender effects in pharmacokinetics and pharmacodynamics. Drugs 50:222\u2013239","journal-title":"Drugs"},{"key":"2555_CR52","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev.nutr.22.011602.092259","volume":"22","author":"LV Hooper","year":"2002","unstructured":"Hooper LV, Midtvedt T, Gordon JI (2002) How host\u2013microbial interactions shape the nutrient environment of the mammalian intestine. Annu Rev Nutr 22:283\u2013307","journal-title":"Annu Rev Nutr"},{"key":"2555_CR53","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1101\/gr.5969107","volume":"17","author":"D Huson","year":"2007","unstructured":"Huson D, Auch A, Qi J, Schuster S (2007a) MEGAN analysis of metagenomic data. Genome Res 17:377\u2013386","journal-title":"Genome Res"},{"key":"2555_CR54","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1101\/gr.5969107","volume":"17","author":"DH Huson","year":"2007","unstructured":"Huson DH, Auch AF, Qi J, Schuster SC (2007b) MEGAN analysis of metagenomic data. Genome Res 17:377\u201386","journal-title":"Genome Res"},{"key":"2555_CR55","unstructured":"Jassim G, Skrede S, V\u00c3\u00a1zquez M, Wergedal H, Vik-Mo A, Lunder N, Di\u00c3\u00a9guez C, Vidal-Puig A, Berge R, L\u00c3\u00b3pez M, Steen V, Fern\u00c3\u00b8 J (2011) Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat. Psychopharmacology: 1\u201312"},{"key":"2555_CR56","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1093\/ajcn\/87.3.534","volume":"87","author":"M Kalliomaki","year":"2008","unstructured":"Kalliomaki M, Collado MC, Salminen S, Isolauri E (2008) Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr 87:534\u2013538","journal-title":"Am J Clin Nutr"},{"key":"2555_CR57","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1124\/jpet.102.046987","volume":"305","author":"S Kapur","year":"2003","unstructured":"Kapur S, Vanderspek SC, Brownlee BA, Nobrega JN (2003) Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy. J Pharmacol Exp Ther 305:625\u2013631","journal-title":"J Pharmacol Exp Ther"},{"key":"2555_CR58","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/sj.ijo.0803259","volume":"30","author":"CS Kim","year":"2006","unstructured":"Kim CS, Park HS, Kawada T, Kim JH, Lim D, Hubbard NE, Kwon BS, Erickson KL, Yu R (2006) Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters. Int J Obes 30:1347\u20131355","journal-title":"Int J Obes"},{"key":"2555_CR59","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jpsychires.2009.11.007","volume":"44","author":"SH Kim","year":"2010","unstructured":"Kim SH, Nikolics L, Abbasi F, Lamendola C, Link J, Reaven GM, Lindley S (2010) Relationship between body mass index and insulin resistance in patients treated with second generation antipsychotic agents. J Psychiatr Res 44:493\u2013498","journal-title":"J Psychiatr Res"},{"key":"2555_CR60","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1097\/jcp.0b013e31815a8872","volume":"27","author":"M Kluge","year":"2007","unstructured":"Kluge M, Schuld A, Himmerich H, Dalal M, Schacht A, Wehmeier PM, Hinze-Selch D, Kraus T, Dittmann RW, Pollmacher T (2007) Clozapine and olanzapine are associated with food craving and binge eating\u2014results from a randomized double-blind study. J Clin Psychopharmacol 27:662\u2013666","journal-title":"J Clin Psychopharmacol"},{"key":"2555_CR61","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.psyneuen.2008.08.016","volume":"34","author":"M Kluge","year":"2009","unstructured":"Kluge M, Schuld A, Schacht A, Himmerich H, Dalal MA, Wehmeier PM, Hinze-Selch D, Kraus T, Dittmann RW, Pollm\u00e4cher T (2009) Effects of clozapine and olanzapine on cytokine systems are closely linked to weight gain and drug-induced fever. Psychoneuroendocrinology 34:118\u2013128","journal-title":"Psychoneuroendocrinology"},{"key":"2555_CR62","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/oby.2001.95","volume":"9","author":"M Kolehmainen","year":"2001","unstructured":"Kolehmainen M, Vidal H, Alhava E, Uusitupa MIJ (2001) Sterol regulatory element binding protein 1c (SREBP-1c) expression in human obesity. Obes Res 9:706\u2013712","journal-title":"Obes Res"},{"key":"2555_CR63","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/sj.npp.1300027","volume":"28","author":"WK Kroeze","year":"2003","unstructured":"Kroeze WK, Hufeisen SJ, Popadak BA, Renock SM, Steinberg S, Ernsberger P, Jayathilake K, Meltzer HY, Roth BL (2003) H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28:519\u2013526","journal-title":"Neuropsychopharmacology"},{"key":"2555_CR64","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1210\/en.2007-1321","volume":"149","author":"DD Lam","year":"2008","unstructured":"Lam DD, Przydzial MJ, Ridley SH, Yeo GS, Rochford JJ, O'Rahilly S, Heisler LK (2008) Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors. Endocrinology 149:1323\u20138","journal-title":"Endocrinology"},{"key":"2555_CR65","first-page":"10","volume":"5","author":"N Larsen","year":"2010","unstructured":"Larsen N, Vogensen FK, van den Berg FWJ, Nielsen DS, Andreasen AS, Pedersen BK, Abu Al-Soud W, Sorensen SJ, Hansen LH, Jakobsen M (2010) Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One 5:10","journal-title":"PLoS One"},{"key":"2555_CR66","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00210-010-0597-3","volume":"383","author":"E Lauressergues","year":"2010","unstructured":"Lauressergues E, Martin F, Helleboid A, Bouchaert E, Cussac D, Bordet R, Hum D, Luc G, Majd Z, Staels B, Duriez P (2010) Overweight induced by chronic risperidone exposure is correlated with overexpression of the SREBP-1c and FAS genes in mouse liver. Naunyn Schmiedebergs Arch Pharmacol 383:423\u2013436","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2555_CR67","doi-asserted-by":"crossref","first-page":"864","DOI":"10.4088\/JCP.v65n0620","volume":"65","author":"E Lee","year":"2004","unstructured":"Lee E, Leung CM, Wong E (2004) Atypical antipsychotics and weight gain in Chinese patients: a comparison of olanzapine and risperidone. J Clin Psychiatry 65:864\u20136","journal-title":"J Clin Psychiatry"},{"key":"2555_CR68","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1073\/pnas.0504978102","volume":"102","author":"RE Ley","year":"2005","unstructured":"Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI (2005) Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A 102:11070\u201311075","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2555_CR69","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1365-2265.2007.02768.x","volume":"66","author":"J Makovey","year":"2007","unstructured":"Makovey J, Naganathan V, Seibel M, Sambrook P (2007) Gender differences in plasma ghrelin and its relations to body composition and bone\u2014an opposite-sex twin study. Clin Endocrinol 66:530\u2013537","journal-title":"Clin Endocrinol"},{"key":"2555_CR70","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.2337\/diabetes.53.9.2250","volume":"53","author":"T Masaki","year":"2004","unstructured":"Masaki T, Chiba S, Yasuda T, Noguchi H, Kakuma T, Watanabe T, Sakata T, Yoshimatsu H (2004) Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity. Diabetes 53:2250\u201360","journal-title":"Diabetes"},{"key":"2555_CR71","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2133\/dmpk.20.368","volume":"20","author":"A Matsui-Sakata","year":"2005","unstructured":"Matsui-Sakata A, Ohtani H, Sawada Y (2005) Receptor occupancy-based analysis of the contributions of various receptors to antipsychotics-induced weight gain and diabetes mellitus. Drug Metab Pharmacokinet 20:368\u201378","journal-title":"Drug Metab Pharmacokinet"},{"key":"2555_CR72","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0920-9964(01)00326-7","volume":"59","author":"HY Meltzer","year":"2003","unstructured":"Meltzer HY, Perry E, Jayathilake K (2003) Clozapine-induced weight gain predicts improvement in psychopathology. Schizophr Res 59:19\u201327","journal-title":"Schizophr Res"},{"key":"2555_CR73","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.appet.2006.01.008","volume":"46","author":"J Minet-Ringuet","year":"2006","unstructured":"Minet-Ringuet J, Even PC, Goubern M, Tome D, de Beaurepaire R (2006) Long term treatment with olanzapine mixed with the food in male rats induces body fat deposition with no increase in body weight and no thermogenic alteration. Appetite 46:254\u201362","journal-title":"Appetite"},{"key":"2555_CR74","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1128\/AEM.72.2.1027-1033.2006","volume":"72","author":"S Mueller","year":"2006","unstructured":"Mueller S, Saunier K, Hanisch C, Norin E, Alm L, Midtvedt T, Cresci A, Silvi S, Orpianesi C, Verdenelli MC, Clavel T, Koebnick C, Zunft HJF, Dore J, Blaut M (2006) Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study. Appl Environ Microbiol 72:1027\u20131033","journal-title":"Appl Environ Microbiol"},{"key":"2555_CR75","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.psyneuen.2004.05.008","volume":"30","author":"M Murashita","year":"2005","unstructured":"Murashita M, Kusumi I, Inoue T, Takahashi Y, Hosoda H, Kangawa K, Koyama T (2005) Olanzapine increases plasma ghrelin level in patients with schizophrenia. Psychoneuroendocrinology 30:106\u2013110","journal-title":"Psychoneuroendocrinology"},{"key":"2555_CR76","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1136\/gut.2010.215665","volume":"59","author":"EF Murphy","year":"2010","unstructured":"Murphy EF, Cotter PD, Healy S, Marques TM, O'Sullivan O, Fouhy F, Clarke SF, O'Toole PW, Quigley EM, Stanton C, Ross PR, O'Doherty RM, Shanahan F (2010) Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models. Gut 59:1635\u20131642","journal-title":"Gut"},{"issue":"Suppl 1","key":"2555_CR77","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0306-4530(02)00114-2","volume":"28","author":"H Nasrallah","year":"2003","unstructured":"Nasrallah H (2003) A review of the effect of atypical antipsychotics on weight. Psychoneuroendocrinology 28(Suppl 1):83\u201396","journal-title":"Psychoneuroendocrinology"},{"key":"2555_CR78","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.clinthera.2004.12.003","volume":"26","author":"JW Newcomer","year":"2004","unstructured":"Newcomer JW (2004) Metabolic risk during antipsychotic treatment. Clin Ther 26:1936\u201346","journal-title":"Clin Ther"},{"issue":"Suppl 1","key":"2555_CR79","first-page":"1","volume":"19","author":"JW Newcomer","year":"2005","unstructured":"Newcomer JW (2005) Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review. CNS Drugs 19(Suppl 1):1\u201393","journal-title":"CNS Drugs"},{"key":"2555_CR80","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.diabet.2008.03.003","volume":"34","author":"P Oriot","year":"2008","unstructured":"Oriot P, Feys JL, Mertens de Wilmars S, Misson A, Ayache L, Fagnart O, Gruson D, Luts A, Jamart J, Hermans MP, Buysschaert M (2008) Insulin sensitivity, adjusted beta-cell function and adiponectinaemia among lean drug-naive schizophrenic patients treated with atypical antipsychotic drugs: a nine-month prospective study. Diabetes Metab 34:490\u20136","journal-title":"Diabetes Metab"},{"key":"2555_CR81","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.schres.2009.03.025","volume":"111","author":"JK Patel","year":"2009","unstructured":"Patel JK, Buckley PF, Woolson S, Hamer RM, McEvoy JP, Perkins DO, Lieberman JA, Investigators C (2009) Metabolic profiles of second-generation antipsychotics in early psychosis: findings from the CAFE study. Schizophr Res 111:9\u201316","journal-title":"Schizophr Res"},{"key":"2555_CR82","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.schres.2008.09.028","volume":"107","author":"R Perez-Iglesias","year":"2009","unstructured":"Perez-Iglesias R, Mata I, Pelayo-Teran JM, Amado JA, Garcia-Unzueta MT, Berja A, Martinez-Garcia O, Vazquez-Barquero JL, Crespo-Facorro B (2009) Glucose and lipid disturbances after 1\u00a0year of antipsychotic treatment in a drug-naive population. Schizophr Res 107:115\u201321","journal-title":"Schizophr Res"},{"key":"2555_CR83","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0091-3057(03)00042-X","volume":"75","author":"B Pouzet","year":"2003","unstructured":"Pouzet B, Mow T, Kreilgaard M, Velschow S (2003) Chronic treatment with antipsychotics in rats as a model for antipsychotic-induced weight gain in human. Pharmacol Biochem Behav 75:133\u201340","journal-title":"Pharmacol Biochem Behav"},{"key":"2555_CR84","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1001\/jama.286.3.327","volume":"286","author":"AD Pradhan","year":"2001","unstructured":"Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM (2001) C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286:327\u2013334","journal-title":"JAMA"},{"key":"2555_CR85","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11010-006-9160-4","volume":"289","author":"MB Raeder","year":"2006","unstructured":"Raeder MB, Ferno J, Vik-Mo AO, Steen VM (2006) SREBP activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: relevance for metabolic side-effects? Mol Cell Biochem 289:167\u2013173","journal-title":"Mol Cell Biochem"},{"key":"2555_CR86","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/sj.npp.1301093","volume":"32","author":"MA Raskind","year":"2007","unstructured":"Raskind MA, Burke BL, Crites NJ, Tapp AM, Rasmussen DD (2007) Olanzapine-induced weight gain and increased visceral adiposity is blocked by melatonin replacement therapy in rats. Neuropsychopharmacology 32:284\u20138","journal-title":"Neuropsychopharmacology"},{"key":"2555_CR87","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/1359786806066040","volume":"20","author":"GP Reynolds","year":"2006","unstructured":"Reynolds GP, Hill MJ, Kirk SL (2006) The 5-HT2C receptor and antipsychotic-induced weight gain\u2014mechanisms and genetics. J Psychopharmacol 20:15\u20138","journal-title":"J Psychopharmacol"},{"key":"2555_CR88","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1016\/S0140-6736(02)08913-4","volume":"359","author":"GP Reynolds","year":"2002","unstructured":"Reynolds GP, Zhang ZJ, Zhang XB (2002) Association of antipsychotic drug-induced weight gain with a 5-HT2C receptor gene polymorphism. Lancet 359:2086\u20137","journal-title":"Lancet"},{"key":"2555_CR89","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ygcen.2005.01.009","volume":"142","author":"LG Riley","year":"2005","unstructured":"Riley LG, Fox BK, Kaiya H, Hirano T, Grau EG (2005) Long-term treatment of ghrelin stimulates feeding, fat deposition, and alters the GH\/IGF-I axis in the tilapia, Oreochromis mossambicus. Gen Comp Endocrinol 142:234\u2013240","journal-title":"Gen Comp Endocrinol"},{"key":"2555_CR90","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S1566-2772(03)00021-5","volume":"3","author":"BL Roth","year":"2003","unstructured":"Roth BL, Sheffler D, Potkin SG (2003) Atypical antipsychotic drug actions: unitary or multiple mechanisms for \"atypicality\"? Clin Neurosci Res 3:108\u2013117","journal-title":"Clin Neurosci Res"},{"key":"2555_CR91","doi-asserted-by":"crossref","first-page":"45777","DOI":"10.1074\/jbc.M301977200","volume":"278","author":"V Rotter","year":"2003","unstructured":"Rotter V, Nagaev I, Smith U (2003) Interleukin-6 (IL-6) induces insulin resistance in 3\u00a0T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 278:45777\u201345784","journal-title":"J Biol Chem"},{"key":"2555_CR92","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neuropharm.2009.06.024","volume":"58","author":"H Schellekens","year":"2010","unstructured":"Schellekens H, Dinan TG, Cryan JF (2010) Lean mean fat reducing \"ghrelin\" machine: hypothalamic ghrelin and ghrelin receptors as therapeutic targets in obesity. Neuropharmacology 58:2\u201316","journal-title":"Neuropharmacology"},{"key":"2555_CR93","doi-asserted-by":"crossref","unstructured":"Schloss PD, Westcott SL, Ryabin T, Hall JR, Hartmann M, Hollister EB, Lesniewski RA, Oakley BB, Parks DH, Robinson CJ, Sahl JW, Stres B, Thallinger GG, Van Horn DJ, Weber CF (2009) Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities. Appl Environ Microbiol 75(23):7537\u20137541","DOI":"10.1128\/AEM.01541-09"},{"key":"2555_CR94","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1176\/appi.ajp.161.8.1324","volume":"161","author":"MV Seeman","year":"2004","unstructured":"Seeman MV (2004) Gender differences in the prescribing of antipsychotic drugs. Am J Psychiatry 161:1324\u20131333","journal-title":"Am J Psychiatry"},{"key":"2555_CR95","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/schbul\/sbm141","volume":"34","author":"O Sentissi","year":"2008","unstructured":"Sentissi O, Epelbaum J, Olie J-P, Poirier M-F (2008) Leptin and ghrelin levels in patients with schizophrenia during different antipsychotics treatment: a review. Schizophr Bull 34:1189\u20131199","journal-title":"Schizophr Bull"},{"key":"2555_CR96","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.bbr.2010.08.046","volume":"216","author":"M Shobo","year":"2011","unstructured":"Shobo M, Yamada H, Mihara T, Kondo Y, Irie M, Harada K, Ni K, Matsuoka N, Kayama Y (2011) Two models for weight gain and hyperphagia as side effects of atypical antipsychotics in male rats: validation with olanzapine and ziprasidone. Behav Brain Res 216:561\u2013568","journal-title":"Behav Brain Res"},{"key":"2555_CR97","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1358\/mf.2005.27.5.908643","volume":"27","author":"JS Silvestre","year":"2005","unstructured":"Silvestre JS, Prous J (2005) Research on adverse drug events. I. Muscarinic M3 receptor binding affinity could predict the risk of antipsychotics to induce type 2 diabetes. Methods Find Exp Clin Pharmacol 27:289\u2013304","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"2555_CR98","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.eurpsy.2009.01.001","volume":"24","author":"FC Starrenburg","year":"2009","unstructured":"Starrenburg FC, Bogers JP (2009) How can antipsychotics cause diabetes mellitus? Insights based on receptor-binding profiles, humoral factors and transporter proteins. Eur Psychiatry 24:164\u201370","journal-title":"Eur Psychiatry"},{"key":"2555_CR99","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1210\/jc.2002-020135","volume":"87","author":"M Straczkowski","year":"2002","unstructured":"Straczkowski M, Dzienis-Straczkowska S, Stepien A, Kowalska I, Szelachowska M, Kinalska I (2002) Plasma interleukin-8 concentrations are increased in obese subjects and related to fat mass and tumor necrosis factor-{alpha} system. J Clin Endocrinol Metab 87:4602\u20134606","journal-title":"J Clin Endocrinol Metab"},{"key":"2555_CR100","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.pnpbp.2008.12.006","volume":"33","author":"H Sugino","year":"2009","unstructured":"Sugino H, Futamura T, Mitsumoto Y, Maeda K, Marunaka Y (2009) Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharide-treated mice. Prog Neuropsychopharmacol Biol Psychiatry 33:303\u2013307","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2555_CR101","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/026988110201600111","volume":"16","author":"Z Thornton-Jones","year":"2002","unstructured":"Thornton-Jones Z, Neill JC, Reynolds GP (2002) The atypical antipsychotic olanzapine enhances ingestive behaviour in the rat: a preliminary study. J Psychopharmacol 16:35\u201337","journal-title":"J Psychopharmacol"},{"key":"2555_CR102","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1079\/BJN20041213","volume":"92","author":"P Trayhurn","year":"2004","unstructured":"Trayhurn P, Wood IS (2004) Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92:347\u2013355","journal-title":"Br J Nutr"},{"key":"2555_CR103","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1080\/15622970903079507","volume":"10","author":"T Treuer","year":"2009","unstructured":"Treuer T, Hoffmann VP, Chen AKP, Irimia V, Ocampo M, Wang G, Singh P, Holt S (2009) Factors associated with weight gain during olanzapine treatment in patients with schizophrenia or bipolar disorder: Results from a six-month prospective, multinational, observational study. World J Biol Psychiatry 10:729\u2013740","journal-title":"World J Biol Psychiatry"},{"key":"2555_CR104","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/153537020222700309","volume":"227","author":"K Tsuda","year":"2002","unstructured":"Tsuda K, Yoshimatsu H, Niijima A, Chiba S, Okeda T, Sakata T (2002) Hypothalamic histamine neurons activate lipolysis in rat adipose tissue. Exp Biol Med (Maywood) 227:208\u2013213","journal-title":"Exp Biol Med (Maywood)"},{"key":"2555_CR105","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.chom.2008.02.015","volume":"3","author":"PJ Turnbaugh","year":"2008","unstructured":"Turnbaugh PJ, Baeckhed F, Fulton L, Gordon JI (2008) Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3:213\u2013223","journal-title":"Cell Host Microbe"},{"key":"2555_CR106","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature07540","volume":"457","author":"PJ Turnbaugh","year":"2009","unstructured":"Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, Egholm M, Henrissat B, Heath AC, Knight R, Gordon JI (2009) A core gut microbiome in obese and lean twins. Nature 457:480\u2013U7","journal-title":"Nature"},{"key":"2555_CR107","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","volume":"444","author":"PJ Turnbaugh","year":"2006","unstructured":"Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444:1027\u20131031","journal-title":"Nature"},{"key":"2555_CR108","doi-asserted-by":"crossref","first-page":"e2527","DOI":"10.1371\/journal.pone.0002527","volume":"3","author":"T Urich","year":"2008","unstructured":"Urich T, Lanzen A, Qi J, Huson DH, Schleper C, Schuster SC (2008) Simultaneous assessment of soil microbial community structure and function through analysis of the meta-transcriptome. PLoS One 3:e2527","journal-title":"PLoS One"},{"key":"2555_CR109","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1080\/00048670903107609","volume":"43","author":"S Verma","year":"2009","unstructured":"Verma S, Liew A, Subramaniam M, Poon LY (2009) Effect of treatment on weight gain and metabolic abnormalities in patients with first-episode psychosis. Aust NZ J Psychiatry 43:812\u20137","journal-title":"Aust NZ J Psychiatry"},{"key":"2555_CR110","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00213-009-1593-5","volume":"206","author":"M Victoriano","year":"2009","unstructured":"Victoriano M, Hermier D, Even PC, Fromentin G, Huneau JF, Tome D, de Beaurepaire R (2009) Early perturbation in feeding behaviour and energy homeostasy in olanzapine-treated rats. Psychopharmacology (Berl) 206:167\u201376","journal-title":"Psychopharmacology (Berl)"},{"key":"2555_CR111","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.schres.2009.09.034","volume":"116","author":"K Weston-Green","year":"2011","unstructured":"Weston-Green K, Huang XF, Deng C (2011) Sensitivity of the female rat to olanzapine-induced weight gain\u2014far from the clinic? Schizophr Res 116:299\u2013300","journal-title":"Schizophr Res"},{"key":"2555_CR112","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1097\/01.ASN.0000141966.69934.21","volume":"15","author":"BE Wisse","year":"2004","unstructured":"Wisse BE (2004) The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol 15:2792\u2013800","journal-title":"J Am Soc Nephrol"},{"key":"2555_CR113","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","volume":"112","author":"HY Xu","year":"2003","unstructured":"Xu HY, Barnes GT, Yang Q, Tan Q, Yang DS, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821\u20131830","journal-title":"J Clin Invest"},{"key":"2555_CR114","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.phrs.2007.05.007","volume":"56","author":"LH Yang","year":"2007","unstructured":"Yang LH, Chen TM, Yu ST, Chen YH (2007) Olanzapine induces SREBP-1-related adipogenesis in 3\u00a0T3-L1 cells. Pharmacol Res 56:202\u2013208","journal-title":"Pharmacol Res"},{"key":"2555_CR115","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jss.2005.04.017","volume":"128","author":"Y Yokoyama","year":"2005","unstructured":"Yokoyama Y, Nimura Y, Nagino M, Bland KI, Chaudry IH (2005) Current understanding of gender dimorphism in hepatic pathophysiology. J Surg Res 128:147\u2013156","journal-title":"J Surg Res"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-011-2555-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-011-2555-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-011-2555-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T17:26:25Z","timestamp":1742318785000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-011-2555-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,11]]},"references-count":115,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["2555"],"URL":"https:\/\/doi.org\/10.1007\/s00213-011-2555-2","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,11]]}}}