{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T04:10:24Z","timestamp":1743912624105,"version":"3.40.3"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,7,24]],"date-time":"2012-07-24T00:00:00Z","timestamp":1343088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1007\/s00213-012-2802-1","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T11:46:34Z","timestamp":1343043994000},"page":"141-150","source":"Crossref","is-referenced-by-count":2,"title":["Residual dopamine receptor desensitization following either high- or low-dose sub-chronic prior exposure to the atypical anti-psychotic drug olanzapine"],"prefix":"10.1007","volume":"225","author":[{"given":"Fl\u00e1via Regina Cruz","family":"Dias","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liana Wermelinger","family":"de Matos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de F\u00e1tima","family":"dos Santos Sampaio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Carey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marinete Pinheiro","family":"Carrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,7,24]]},"reference":[{"key":"2802_CR1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/B978-0-08-017922-3.50120-9","volume-title":"Frontiers in catecholamine research","author":"GK Aghajanian","year":"1973","unstructured":"Aghajanian GK, Bunney BS (1973) Central dopaminergic neurons: neurophysiological identification and responses to drugs. In: Usdin E, Snyder SH (eds) Frontiers in catecholamine research. Pergamon, New York, pp 643\u2013648"},{"key":"2802_CR2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.pbb.2007.01.002","volume":"86","author":"E Bloise","year":"2007","unstructured":"Bloise E, Carey RJ, Carrera MP (2007) Behavioral sensitization produced by a single administration of apomorphine: implications for the role of Pavlovian conditioning in the mediation of context-specific sensitization. Pharmacol Biochem Behav 86:449\u2013457","journal-title":"Pharmacol Biochem Behav"},{"key":"2802_CR3","first-page":"1299","volume":"13","author":"A Bortolozzi","year":"2010","unstructured":"Bortolozzi A, Masana M, Diaz-Mataix L, Cortes R, Scorza MC, Gingrich JA, Toth M, Artigas F (2010) Dopamine release induced by atypical antipsychotics in prefrontal cortex requires 5-HT(1A) receptors but not 5-HT(2A) receptors. Int J Neuropharmacol 13:1299\u20131314","journal-title":"Int J Neuropharmacol"},{"key":"2802_CR4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.bbr.2009.06.001","volume":"204","author":"PQ Braga","year":"2009","unstructured":"Braga PQ, Dias FR, Carey RJ, Carrera MP (2009a) Behavioral sensitization to dopaminergic inhibitory and stimulatory effects induced by low vs. high dose apomorphine treatments: an unconventional dose and response reversal sensitization challenge test reveals sensitization mechanisms. Behav Brain Res 204:169\u2013174","journal-title":"Behav Brain Res"},{"key":"2802_CR5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.pbb.2009.04.019","volume":"93","author":"PQ Braga","year":"2009","unstructured":"Braga PQ, Dias FR, Carey RJ, Carrera MP (2009b) Low dose apomorphine induces context-specific sensitization of hypolocomotion without conditioning: support for a new state dependent retrieval hypothesis of drug conditioning and sensitization. Pharmacol Biochem Behav 93:128\u2013133","journal-title":"Pharmacol Biochem Behav"},{"key":"2802_CR6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-8993(91)91399-L","volume":"568","author":"RJ Carey","year":"1991","unstructured":"Carey RJ (1991) Chronic l-dopa treatment in the unilateral 6-OHDA rat: evidence for behavioral sensitization and biochemical tolerance. Brain Res 568:205\u2013214","journal-title":"Brain Res"},{"key":"2802_CR7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/BF00449122","volume":"76","author":"RJ Carey","year":"1982","unstructured":"Carey RJ, De Veaugh-Geiss J (1982) Chronic benzotropine and haloperidol administration induces behaviorally equivalent pharmacological hypersensitivities separately but not in combination. Psychopharmacology 76:341\u2013345","journal-title":"Psychopharmacology"},{"key":"2802_CR8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0166-4328(97)00126-5","volume":"92","author":"RJ Carey","year":"1998","unstructured":"Carey RJ, Gui J (1998) Cocaine conditioning and cocaine sensitization: what is the relationship? Behav Brain Res 92:67\u201376","journal-title":"Behav Brain Res"},{"key":"2802_CR9","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.brainres.2004.05.091","volume":"1019","author":"RJ Carey","year":"2004","unstructured":"Carey RJ, DePalma G, Damianopoulos E, Hopkins A, Shanahan A, M\u00fcller CP, Huston JP (2004) Dopaminergic and serotonergic autoreceptor stimulation effects are equivalent and additive in the suppression of spontaneous and cocaine induced locomotor activity. Brain Res 1019:134\u2013143","journal-title":"Brain Res"},{"key":"2802_CR10","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0149-7634(94)90004-3","volume":"18","author":"A Cerbone","year":"1994","unstructured":"Cerbone A, Sadile AG (1994) Behavioral habituation to spatial novelty: interference and noninterference studies. Neurosci Biobehav Rev 18:497\u2013518","journal-title":"Neurosci Biobehav Rev"},{"key":"2802_CR11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.pbb.2010.04.004","volume":"96","author":"CL Danna","year":"2010","unstructured":"Danna CL, Elmer GI (2010) Disruption of conditioned reward association by typical and atypical antipsychotics. Pharmacol Biochem Behav 96:40\u201347","journal-title":"Pharmacol Biochem Behav"},{"key":"2802_CR12","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.pbb.2010.05.025","volume":"96","author":"LW Matos de","year":"2010","unstructured":"de Matos LW, Carey RJ, Carrera MP (2010) Apomorphine conditioning and sensitization: the paired\/unpaired treatment order as a new major determinant of drug conditioned and sensitization effects. Pharmacol Biochem Behav 96:317\u2013324","journal-title":"Pharmacol Biochem Behav"},{"key":"2802_CR13","volume-title":"Tardive dyskinesia and related involuntary movement disorders","author":"J Veaugh-Geiss De","year":"1982","unstructured":"De Veaugh-Geiss J (1982) Tardive dyskinesia and related involuntary movement disorders. John Wright PSG, Boston"},{"key":"2802_CR14","first-page":"1289","volume":"17","author":"J Veaugh-Geiss De","year":"1982","unstructured":"De Veaugh-Geiss J, Carey RJ (1982) Differential liabilities of haloperidol and thioridazine for inducing apomorphine hypersensitivity. Biol Psychiat 17:1289\u20131301","journal-title":"Biol Psychiat"},{"key":"2802_CR15","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/267270a0","volume":"267","author":"G Chiara Di","year":"1977","unstructured":"Di Chiara G, Porceddu ML, Fratta W, Gessa GL (1977) Postsynaptic receptors are not essential for dopaminergic feedback regulation. Nature 267:270\u2013272","journal-title":"Nature"},{"key":"2802_CR16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00213-009-1768-0","volume":"209","author":"FR Dias","year":"2010","unstructured":"Dias FR, Carey RJ, Carrera MP (2010) Apomorphine-induced context-specific behavioural sensitization is prevented by the D1 antagonist SCH-23390 but potentiated and uncoupled from contextual cues by the D2 antagonist sulpiride. Psychopharmacology 209:137\u2013151","journal-title":"Psychopharmacology"},{"key":"2802_CR17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbr.2011.12.042","volume":"229","author":"FR Dias","year":"2012","unstructured":"Dias FR, de Matos LW, Sampaio MD, Carey RJ, Carrera MP (2012) Opposite effects of low versus high dose haloperidol treatments on spontaneous and apomorphine induced motor behavior: Evidence that at a very low dose haloperidol acts as an indirect dopamine agonist. Behav Brain Res 229:153\u2013159","journal-title":"Behav Brain Res"},{"key":"2802_CR18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pbb.2010.05.029","volume":"97","author":"SS Evers","year":"2010","unstructured":"Evers SS, Calcagnoli F, van Dijk G, Scheurink AJ (2010) Olanzapine causes hypothermia, inactivity, a deranged feeding pattern and weight gain in female Wistar rats. Pharmacol Biochem Behav 97:163\u2013169","journal-title":"Pharmacol Biochem Behav"},{"key":"2802_CR19","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1177\/0897190011426556","volume":"24","author":"JH Friedman","year":"2011","unstructured":"Friedman JH (2011) Atypical antipsychotic drugs in the treatment of Parkinson's disease. J Pharm Pract 24:534\u2013540","journal-title":"J Pharm Pract"},{"key":"2802_CR20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0197-0186(96)00093-9","volume":"30","author":"N Huang","year":"1997","unstructured":"Huang N, Ase AR, Hebert C, van Gelder NM, Reader TA (1997) Effects of chronic neuroleptic treatments on dopamine D1 and D2 receptors: homogenate binding and autoradiographic studies. Neurochem Int 30:277\u2013290","journal-title":"Neurochem Int"},{"key":"2802_CR21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.psychres.2010.02.009","volume":"177","author":"F Iasevoli","year":"2010","unstructured":"Iasevoli F, Flore G, Cicale M, Muscettola G, de Bartolomeis A (2010) Haloperidol induces higsher Homerla expression than resperidone, olanzapine and sulpiride in striatal subregions. Psychiatry Res 177:255\u2013260","journal-title":"Psychiatry Res"},{"key":"2802_CR22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/syn.1035","volume":"40","author":"JN Joyce","year":"2001","unstructured":"Joyce JN (2001) D2 but not D3 receptors are elevated after 9 or 11 months chronic haloperidol treatment: influence of withdrawal period. Synapse 40:137\u2013144","journal-title":"Synapse"},{"key":"2802_CR23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00008877-200205000-00002","volume":"13","author":"S Keller","year":"2002","unstructured":"Keller S, Delius JD, Acerbo MJ (2002) Apomorphine sensitization: evoking conditions, context dependence, effect persistence and conditioned nature. Behav Pharmacol 13:189\u2013201","journal-title":"Behav Pharmacol"},{"key":"2802_CR24","first-page":"46","volume":"212","author":"M Li","year":"2010","unstructured":"Li M, Sun T, Zhang C, Hu G (2010) Distinct neural mechanisms underlying acute and repeated administration of antipsychotic drugs in rat avoidance conditioning. Psychopharmacology 212:46\u201357","journal-title":"Psychopharmacology"},{"key":"2802_CR25","doi-asserted-by":"crossref","first-page":"502","DOI":"10.2174\/138161210790361416","volume":"16","author":"X Lopez-Gil","year":"2010","unstructured":"Lopez-Gil X, Artigas F, Adell A (2010) Unraveling monoamine receptors involved in the action of typical and atypical antipsychotics on glutamatergic and serotonergic transmission in prefrontal cortex. Curr Pharma Des 16:502\u2013515","journal-title":"Curr Pharma Des"},{"key":"2802_CR26","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1037\/0735-7044.103.6.1311","volume":"103","author":"BA Mattingly","year":"1989","unstructured":"Mattingly BA, Gotsick JE (1989) Conditioning and experiential factors affecting the development of sensitization to apomorphine. Behav Neurosci 103:1311\u20131317","journal-title":"Behav Neurosci"},{"key":"2802_CR27","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/BF02244370","volume":"105","author":"BA Mattingly","year":"1991","unstructured":"Mattingly BA, Rowlett JK, Graff JT, Hatton BJ (1991) Effects of selective D1 and D2 dopamine antagonists on the development of behavioral sensitization to apomorphine. Psychopharmacology 105:501\u2013507","journal-title":"Psychopharmacology"},{"key":"2802_CR28","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0091-3057(00)00471-8","volume":"68","author":"BA Mattingly","year":"2001","unstructured":"Mattingly BA, Caudill A, Abel M (2001) Differential effects of 7-OH-DPAT on the development of behavioral sensitization to apomorphine and cocaine. Pharmacol Biochem Behav 68:417\u2013426","journal-title":"Pharmacol Biochem Behav"},{"key":"2802_CR29","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1038\/npp.2010.50","volume":"35","author":"PN McCormick","year":"2010","unstructured":"McCormick PN, Kapur S, Graff-Guerrero A, Raymond R, Nobrega JN, Wilson AA (2010) The antipsychotics olanzapine, risperidone, clozapine and haloperidol are D2-selective ex vivo but not in vitro. Neurpsychopharmacology 35:1826\u20131835","journal-title":"Neurpsychopharmacology"},{"key":"2802_CR30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.coph.2011.02.007","volume":"11","author":"HY Meltzer","year":"2011","unstructured":"Meltzer HY, Massey BW (2011) The role of serotonin receptors in the action of atypical antipsychotic drugs. Curr Opin Pharmacol 11:59\u201367","journal-title":"Curr Opin Pharmacol"},{"key":"2802_CR31","first-page":"617","volume":"81","author":"J Muench","year":"2010","unstructured":"Muench J, Hamer AM (2010) Adverse effects of antipsychotic medications. Am Fam Physician 81:617\u2013622","journal-title":"Am Fam Physician"},{"key":"2802_CR32","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0031-9384(97)00462-9","volume":"63","author":"AG Nasello","year":"1998","unstructured":"Nasello AG, Machado C, Bastos JF (1998) Felicio LF (1998) Sudden darkness induces a high activity-low anxiety state in male and female rats. Physiol Behav 63:451\u2013454","journal-title":"Physiol Behav"},{"key":"2802_CR33","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00001756-199107000-00002","volume":"2","author":"M Rodriguiez","year":"1991","unstructured":"Rodriguiez M, Castro M (1991) Apomorphine lower dopamine synthesis for up to 48 h: implications for drug sensitization. NeuroReport 2:365\u2013368","journal-title":"NeuroReport"},{"key":"2802_CR34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0091-3057(96)00397-8","volume":"57","author":"JK Rowlett","year":"1997","unstructured":"Rowlett JK, Mattingly BA, Bardos MT (1997) Locomotor activity and dopamine synthesis following 1 and 15 days of withdrawal from repeated apomorpohine treatments. Pharmacol Biochem Behav 57:11\u201318","journal-title":"Pharmacol Biochem Behav"},{"key":"2802_CR35","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0022-3565(25)23998-2","volume":"271","author":"U Schr\u00f6der","year":"1994","unstructured":"Schr\u00f6der U, Schr\u00f6der H, Augustin W, Sabel BA (1994) Haloperidol-induced behavioral supersensitivity is increased by monosialoganglioside treatment in rats without affecting spiroperidol-binding. J Pharmacol Exp Ther 271:1193\u20131196","journal-title":"J Pharmacol Exp Ther"},{"key":"2802_CR36","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/BF00435275","volume":"76","author":"TF Seeger","year":"1982","unstructured":"Seeger TF, Thal L, Gardner EL (1982) Behavioral and biochemical aspects of neuroleptic-induced dopaminergic supersensitivity: studies with chronic clozapine and haloperidol. Psychopharmacology 76:182\u2013187","journal-title":"Psychopharmacology"},{"key":"2802_CR37","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3371\/CSRP.4.1.5","volume":"4","author":"P Seeman","year":"2010","unstructured":"Seeman P (2010) Dopamine D2 receptors as treatment targets in schizophrenia. Clin Schizophr Relat Psychoses 4:56\u201373","journal-title":"Clin Schizophr Relat Psychoses"},{"key":"2802_CR38","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/syn.20303","volume":"60","author":"P Seeman","year":"2006","unstructured":"Seeman P, Schwarz J, Chen JF, Szechtman HP, Perreault M, McKnight GS, Roder JC, Quirion R, Boksa P, Srivastava LK, Hanai K, Weinshenker D, Sumiyoshi T (2006) Psychosis pathways converge via D2 high dopamine receptors. Synapse 60:319\u2013346","journal-title":"Synapse"},{"key":"2802_CR39","doi-asserted-by":"crossref","first-page":"516","DOI":"10.2174\/138920010791636202","volume":"11","author":"JJ Sheehan","year":"2010","unstructured":"Sheehan JJ, Sliwa JK, Amatniek JC, Grinspan A, Canuso CM (2010) Atypical antipsychotic metabolism and excretion. Curr Drug Metab 11:516\u2013525","journal-title":"Curr Drug Metab"},{"key":"2802_CR40","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.482929","volume":"206","author":"LR Skirboll","year":"1979","unstructured":"Skirboll LR, Grace AA, Bunney BS (1979) Dopamine auto- and postsynaptic receptors: electrophysiological evidence for differential sensitivity to dopamine agonists. Science 206:80\u201382","journal-title":"Science"},{"key":"2802_CR41","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1440-1819.2009.01982.x","volume":"63","author":"H Tuppurainen","year":"2009","unstructured":"Tuppurainen H, Kuikka JT, Vilnamaki H, Husso M, Tilhonen J (2009) Dopamine D2\/3 receptor binding potential and occupancy in midbrain and temporal cortex by haloperidol, olanzapine and clozapine. Psychiatry Clin Neurosci 63:529\u2013537","journal-title":"Psychiatry Clin Neurosci"},{"key":"2802_CR42","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/JCP.0b013e3181d2ef6f","volume":"30","author":"S Walther","year":"2010","unstructured":"Walther S, Hum H, Razavi N, Koschorke P, Wopfner A, Muller TJ, Strik W (2010) Higher motor activity in Schizophrenia patients treated with olanzapine vs. risperidone. J Clin Psychopharmacol 30:181\u2013184","journal-title":"J Clin Psychopharmacol"},{"key":"2802_CR43","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/npp.2010.195","volume":"36","author":"PN Yaday","year":"2011","unstructured":"Yaday PN, Abas AI, Fairrell MS, Setola V, Sciaky N, Huang XP, Crawford LK, Piel DA, Keiser MJ, Irwin JJ, Shoichet BK, Deneris ES, Gingrich J, Beck SG, Roth BL (2011) The presynaptic component of the serotonergic system is required for clozapine's efficacy. Neuropsychopharmacology 36:638\u2013651","journal-title":"Neuropsychopharmacology"},{"key":"2802_CR44","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF01250708","volume":"86","author":"KA Young","year":"1991","unstructured":"Young KA, Zavodny R, Hicks PB (1991) Subchronic buspirone, mesulergine, and ICS 205-930 lack effects on D1 and D2 dopamine binding in the rat striatum during chronic haloperidol treatment. J Neural Transm Gen Sect 86:223\u2013228","journal-title":"J Neural Transm Gen Sect"},{"key":"2802_CR45","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2165\/00002512-200825080-00004","volume":"25","author":"LB Zahodne","year":"2008","unstructured":"Zahodne LB, Fernandez HH (2008) Pathophysiology and treatment of psychosis in Parkinson's disease: a review. Drugs Aging 25:665\u2013682","journal-title":"Drugs Aging"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-012-2802-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-012-2802-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-012-2802-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T07:26:30Z","timestamp":1743837990000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-012-2802-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,24]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["2802"],"URL":"https:\/\/doi.org\/10.1007\/s00213-012-2802-1","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"type":"print","value":"0033-3158"},{"type":"electronic","value":"1432-2072"}],"subject":[],"published":{"date-parts":[[2012,7,24]]}}}