{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T21:30:14Z","timestamp":1772659814723,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,8,30]],"date-time":"2012-08-30T00:00:00Z","timestamp":1346284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1007\/s00213-012-2841-7","type":"journal-article","created":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T08:11:35Z","timestamp":1346227895000},"page":"543-551","source":"Crossref","is-referenced-by-count":38,"title":["Galantamine increases hippocampal insulin-like growth factor 2 expression via \u03b17 nicotinic acetylcholine receptors in mice"],"prefix":"10.1007","volume":"225","author":[{"given":"Yuki","family":"Kita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Ago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Takano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asako","family":"Fukada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Takuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,8,30]]},"reference":[{"key":"2841_CR1","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1038\/emboj.2011.293","volume":"30","author":"RC Agis-Balboa","year":"2011","unstructured":"Agis-Balboa RC, Arcos-Diaz D, Wittnam J, Govindarajan N, Blom K, Burkhardt S, Haladyniak U, Agbemenyah HY, Zovoilis A, Salinas-Riester G, Opitz L, Sananbenesi F, Fischer A (2011) A hippocampal insulin-growth factor 2 pathway regulates the extinction of fear memories. EMBO J 30:4071\u20134083","journal-title":"EMBO J"},{"key":"2841_CR2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1254\/jphs.11R01CR","volume":"116","author":"Y Ago","year":"2011","unstructured":"Ago Y, Koda K, Takuma K, Matsuda T (2011) Pharmacological aspects of the acetylcholinesterase inhibitor galantamine. J Pharmacol Sci 116:6\u201317","journal-title":"J Pharmacol Sci"},{"key":"2841_CR3","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.neuropharm.2011.10.004","volume":"62","author":"Y Ago","year":"2012","unstructured":"Ago Y, Tanaka T, Kita Y, Tokumoto H, Takuma K, Matsuda T (2012) Lithium attenuates methamphetamine-induced hyperlocomotion and behavioral sensitization via modulation of prefrontal monoamine release. Neuropharmacology 62:1634\u20131639","journal-title":"Neuropharmacology"},{"key":"2841_CR4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0165-3806(02)00277-8","volume":"134","author":"MF Anderson","year":"2002","unstructured":"Anderson MF, Aberg MA, Nilsson M, Eriksson PS (2002) Insulin-like growth factor-I and neurogenesis in the adult mammalian brain. Brain Res Dev Brain Res 134:115\u2013122","journal-title":"Brain Res Dev Brain Res"},{"key":"2841_CR5","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.neuropharm.2011.07.033","volume":"61","author":"H Autio","year":"2011","unstructured":"Autio H, M\u00e4tlik K, Rantam\u00e4ki T, Lindemann L, Hoener MC, Chao M, Arum\u00e4e U, Castr\u00e9n E (2011) Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus. Neuropharmacology 61:1291\u20131296","journal-title":"Neuropharmacology"},{"key":"2841_CR6","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0306-4522(97)00323-0","volume":"83","author":"N Belluardo","year":"1998","unstructured":"Belluardo N, Blum M, Mudo G, Andbjer B, Fuxe K (1998) Acute intermittent nicotine treatment produces regional increases of basic fibroblast growth factor messenger RNA and protein in the tel- and diencephalon of the rat. Neuroscience 83:723\u2013740","journal-title":"Neuroscience"},{"key":"2841_CR7","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0169-328X(99)00266-1","volume":"74","author":"N Belluardo","year":"1999","unstructured":"Belluardo N, Mud\u00f2 G, Blum M, Cheng Q, Caniglia G, Dell\u2019Albani P, Fuxe K (1999) The nicotinic acetylcholine receptor agonist (\u00b1)-epibatidine increases FGF-2 mRNA and protein levels in the rat brain. Brain Res Mol Brain Res 74:98\u2013110","journal-title":"Brain Res Mol Brain Res"},{"key":"2841_CR8","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1523\/JNEUROSCI.4248-11.2012","volume":"32","author":"O Bracko","year":"2012","unstructured":"Bracko O, Singer T, Aigner S, Knobloch M, Winner B, Ray J, Clemenson GD Jr, Suh H, Couillard-Despres S, Aigner L, Gage FH, Jessberger S (2012) Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis. J Neurosci 32:3376\u20133387","journal-title":"J Neurosci"},{"key":"2841_CR9","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.tibs.2009.07.003","volume":"34","author":"J Brown","year":"2009","unstructured":"Brown J, Jones EY, Forbes BE (2009) Keeping IGF-II under control: lessons from the IGF-II\u2013IGF2R crystal structure. Trends Biochem Sci 34:612\u2013619","journal-title":"Trends Biochem Sci"},{"key":"2841_CR10","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/ng1395","volume":"36","author":"L Cao","year":"2004","unstructured":"Cao L, Jiao X, Zuzga DS, Liu Y, Fong DM, Young D, During MJ (2004) VEGF links hippocampal activity with neurogenesis, learning and memory. Nat Genet 36:827\u2013835","journal-title":"Nat Genet"},{"key":"2841_CR11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cytogfr.2008.01.005","volume":"19","author":"W Chao","year":"2008","unstructured":"Chao W, D\u2019Amore PA (2008) IGF2: epigenetic regulation and role in development and disease. Cytokine Growth Factor Rev 19:111\u2013120","journal-title":"Cytokine Growth Factor Rev"},{"key":"2841_CR12","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nature09667","volume":"469","author":"DY Chen","year":"2011","unstructured":"Chen DY, Stern SA, Garcia-Osta A, Saunier-Rebori B, Pollonini G, Bambah-Mukku D, Blitzer RD, Alberini CM (2011) A critical role for IGF-II in memory consolidation and enhancement. Nature 469:491\u2013497","journal-title":"Nature"},{"key":"2841_CR13","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/nature00819","volume":"417","author":"M Const\u00e2ncia","year":"2002","unstructured":"Const\u00e2ncia M, Hemberger M, Hughes J, Dean W, Ferguson-Smith A, Fundele R, Stewart F, Kelsey G, Fowden A, Sibley C, Reik W (2002) Placental-specific IGF-II is a major modulator of placental and fetal growth. Nature 417:945\u2013948","journal-title":"Nature"},{"key":"2841_CR14","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/sj.npp.1300761","volume":"30","author":"JG Csernansky","year":"2005","unstructured":"Csernansky JG, Martin M, Shah R, Bertchume A, Colvin J, Dong H (2005) Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice. Neuropsychopharmacology 30:2135\u20132143","journal-title":"Neuropsychopharmacology"},{"key":"2841_CR15","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1124\/mol.64.5.1217","volume":"64","author":"FA Dajas-Bailador","year":"2003","unstructured":"Dajas-Bailador FA, Heimala K, Wonnacott S (2003) The allosteric potentiation of nicotinic acetylcholine receptors by galantamine is transduced into cellular responses in neurons: Ca2+ signals and neurotransmitter release. Mol Pharmacol 64:1217\u20131226","journal-title":"Mol Pharmacol"},{"key":"2841_CR16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1017\/S1461145706007103","volume":"10","author":"B Cara Di","year":"2007","unstructured":"Di Cara B, Panayi F, Gobert A, Dekeyne A, Sicard D, De Groote L, Millan MJ (2007) Activation of dopamine D1 receptors enhances cholinergic transmission and social cognition: a parallel dialysis and behavioural study in rats. Int J Neuropsychopharmacol 10:383\u2013399","journal-title":"Int J Neuropsychopharmacol"},{"key":"2841_CR17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.nbd.2006.11.015","volume":"26","author":"H Frielingsdorf","year":"2007","unstructured":"Frielingsdorf H, Simpson DR, Thal LJ, Pizzo DP (2007) Nerve growth factor promotes survival of new neurons in the adult hippocampus. Neurobiol Dis 26:47\u201355","journal-title":"Neurobiol Dis"},{"issue":"Suppl 3","key":"2841_CR18","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000091503","volume":"65","author":"C Gicquel","year":"2006","unstructured":"Gicquel C, Le Bouc Y (2006) Hormonal regulation of fetal growth. Horm Res 65(Suppl 3):28\u201333","journal-title":"Horm Res"},{"key":"2841_CR19","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/hipo.20812","volume":"21","author":"FJ Gil-Bea","year":"2011","unstructured":"Gil-Bea FJ, Solas M, Mateos L, Winblad B, Ram\u00edrez MJ, Cedazo-M\u00ednguez A (2011) Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF downregulation. Hippocampus 21:999\u20131009","journal-title":"Hippocampus"},{"key":"2841_CR20","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1124\/mol.64.4.865","volume":"64","author":"AA Jensen","year":"2003","unstructured":"Jensen AA, Mikkelsen I, Fr\u00f8lund B, Br\u00e4uner-Osborne EF, Krogsgaard-Larsen P (2003) Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors. Mol Pharmacol 64:865\u2013875","journal-title":"Mol Pharmacol"},{"key":"2841_CR21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.brainres.2006.02.081","volume":"1085","author":"K Jin","year":"2006","unstructured":"Jin K, Xie L, Mao XO, Greenberg DA (2006) Alzheimer\u2019s disease drugs promote neurogenesis. Brain Res 1085:183\u2013188","journal-title":"Brain Res"},{"key":"2841_CR22","first-page":"1","volume":"18","author":"S Kataoka","year":"2012","unstructured":"Kataoka S, Takuma K, Hara Y, Maeda Y, Ago Y, Matsuda T (2011) Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid. Int J Neuropsychopharmacol Nov. 18:1\u201313 PMID: 22093185","journal-title":"Int J Neuropsychopharmacol"},{"key":"2841_CR23","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0169-328X(00)00246-1","volume":"85","author":"PJ Kenny","year":"2000","unstructured":"Kenny PJ, File SE, Rattray M (2000) Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus. Brain Res Mol Brain Res 85:234\u2013238","journal-title":"Brain Res Mol Brain Res"},{"key":"2841_CR24","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.bbrc.2004.10.132","volume":"325","author":"T Kihara","year":"2004","unstructured":"Kihara T, Sawada H, Nakamizo T, Kanki R, Yamashita H, Maelicke A, Shimohama S (2004) Galantamine modulates nicotinic receptor and blocks A\u03b2-enhanced glutamate toxicity. Biochem Biophys Res Commun 325:976\u2013982","journal-title":"Biochem Biophys Res Commun"},{"key":"2841_CR25","doi-asserted-by":"crossref","unstructured":"Koda K, Ago Y, Kawasaki T, Hashimoto H, Baba A, Matsuda T (2008) Galantamine and donepezil differently affect isolation rearing-induced deficits of prepulse inhibition in mice. Psychopharmacology Berl 196:293\u2013301","DOI":"10.1007\/s00213-007-0962-1"},{"key":"2841_CR26","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/j.1476-5381.2010.01080.x","volume":"162","author":"K Koda","year":"2011","unstructured":"Koda K, Ago Y, Yano K, Nishimura M, Kobayashi H, Fukada A, Takuma K, Matsuda T (2011) Involvement of decreased muscarinic receptor function in prepulse inhibition deficits in mice reared in social isolation. Br J Pharmacol 162:763\u2013772","journal-title":"Br J Pharmacol"},{"key":"2841_CR27","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1046\/j.1471-4159.2002.01085.x","volume":"82","author":"J Lee","year":"2002","unstructured":"Lee J, Duan W, Mattson MP (2002) Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem 82:1367\u20131375","journal-title":"J Neurochem"},{"key":"2841_CR28","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.neuron.2011.01.023","volume":"69","author":"MK Lehtinen","year":"2011","unstructured":"Lehtinen MK, Zappaterra MW, Chen X, Yang YJ, Hill AD, Lun M, Maynard T, Gonzalez D, Kim S, Ye P, D\u2019Ercole AJ, Wong ET, LaMantia AS, Walsh CA (2011) The cerebrospinal fluid provides a proliferative niche for neural progenitor cells. Neuron 69:893\u2013905","journal-title":"Neuron"},{"key":"2841_CR29","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/1073858408331371","volume":"15","author":"M Llorens-Mart\u00edn","year":"2009","unstructured":"Llorens-Mart\u00edn M, Torres-Alem\u00e1n I, Trejo JL (2009) Mechanisms mediating brain plasticity: IGF1 and adult hippocampal neurogenesis. Neuroscientist 15:134\u2013148","journal-title":"Neuroscientist"},{"key":"2841_CR30","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0166-4328(00)00214-X","volume":"113","author":"A Maelicke","year":"2000","unstructured":"Maelicke A, Schrattenholz A, Samochocki M, Radina M, Albuquerque EX (2000) Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer\u2019s disease. Behav Brain Res 113:199\u2013206","journal-title":"Behav Brain Res"},{"key":"2841_CR31","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0006-3223(00)01109-4","volume":"49","author":"A Maelicke","year":"2001","unstructured":"Maelicke A, Samochocki M, Jostock R, Fehrenbacher A, Ludwig J, Albuquerque EX, Zerlin M (2001) Allosteric sensitization of nicotinic receptors by galantamine, a new treatment strategy for Alzheimer\u2019s disease. Biol Psychiatry 49:279\u2013288","journal-title":"Biol Psychiatry"},{"key":"2841_CR32","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00702-006-0561-z","volume":"114","author":"G Mudo","year":"2007","unstructured":"Mudo G, Belluardo N, Fuxe K (2007) Nicotinic receptor agonists as neuroprotective\/neurotrophic drugs. Progress in molecular mechanisms. J Neural Transm 114:135\u2013147","journal-title":"J Neural Transm"},{"key":"2841_CR33","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1017\/S1461145710000222","volume":"13","author":"Y Noda","year":"2010","unstructured":"Noda Y, Mouri A, Ando Y, Waki Y, Yamada SN, Yoshimi A, Yamada K, Ozaki N, Wang D, Nabeshima T (2010) Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1\/2 systems. Int J Neuropsychopharmacol 13:1343\u20131354","journal-title":"Int J Neuropsychopharmacol"},{"key":"2841_CR34","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1111\/j.1460-9568.2006.05059.x","volume":"24","author":"C Rossi","year":"2006","unstructured":"Rossi C, Angelucci A, Costantin L, Braschi C, Mazzantini M, Babbini F, Fabbri ME, Tessarollo L, Maffei L, Berardi N, Caleo M (2006) Brain-derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment. Eur J Neurosci 24:1850\u20131856","journal-title":"Eur J Neurosci"},{"key":"2841_CR35","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1124\/jpet.102.045773","volume":"305","author":"M Samochocki","year":"2003","unstructured":"Samochocki M, H\u00f6ffle A, Fehrenbacher A, Jostock R, Ludwig J, Christner C, Radina M, Zerlin M, Ullmer C, Pereira EF, L\u00fcbbert H, Albuquerque EX, Maelicke A (2003) Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J Pharmacol Exp Ther 305:1024\u20131036","journal-title":"J Pharmacol Exp Ther"},{"key":"2841_CR36","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1124\/mol.61.5.1222","volume":"61","author":"MD Santos","year":"2002","unstructured":"Santos MD, Alkondon M, Pereira EF, Aracava Y, Eisenberg HM, Maelicke A, Albuquerque EX (2002) The nicotinic allosteric potentiating ligand galantamine facilitates synaptic transmission in the mammalian central nervous system. Mol Pharmacol 61:1222\u20131234","journal-title":"Mol Pharmacol"},{"key":"2841_CR37","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1750-3639.2004.tb00060.x","volume":"14","author":"A Sch\u00e4nzer","year":"2004","unstructured":"Sch\u00e4nzer A, Wachs FP, Wilhelm D, Acker T, Cooper-Kuhn C, Beck H, Winkler J, Aigner L, Plate KH, Kuhn HG (2004) Direct stimulation of adult neural stem cells in vitro and neurogenesis in vivo by vascular endothelial growth factor. Brain Pathol 14:237\u2013248","journal-title":"Brain Pathol"},{"key":"2841_CR38","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/sj.npp.1301087","volume":"32","author":"B Schilstr\u00f6m","year":"2007","unstructured":"Schilstr\u00f6m B, Ivanov VB, Wiker C, Svensson TH (2007) Galantamine enhances dopaminergic neurotransmission in vivo via allosteric potentiation of nicotinic acetylcholine receptors. Neuropsychopharmacology 32:43\u201353","journal-title":"Neuropsychopharmacology"},{"key":"2841_CR39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0026-895X(25)08675-4","volume":"49","author":"A Schrattenholz","year":"1996","unstructured":"Schrattenholz A, Pereira EF, Roth U, Weber KH, Albuquerque EX, Maelicke A (1996) Agonist responses of neuronal nicotinic acetylcholine receptors are potentiated by a novel class of allosterically acting ligands. Mol Pharmacol 49:1\u20136","journal-title":"Mol Pharmacol"},{"key":"2841_CR40","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1124\/jpet.103.063586","volume":"309","author":"BM Sharp","year":"2004","unstructured":"Sharp BM, Yatsula M, Fu Y (2004) Effects of galantamine, a nicotinic allosteric potentiating ligand, on nicotine-induced catecholamine release in hippocampus and nucleus accumbens of rats. J Pharmacol Exp Ther 309:1116\u20131123","journal-title":"J Pharmacol Exp Ther"},{"key":"2841_CR41","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.neulet.2004.04.067","volume":"365","author":"M Sobrado","year":"2004","unstructured":"Sobrado M, Roda JM, L\u00f3pez MG, Egea J, Garc\u00eda AG (2004) Galantamine and memantine produce different degrees of neuroprotection in rat hippocampal slices subjected to oxygen-glucose deprivation. Neurosci Lett 365:132\u2013136","journal-title":"Neurosci Lett"},{"key":"2841_CR42","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.neuropharm.2006.04.007","volume":"51","author":"Y Takada-Takatori","year":"2006","unstructured":"Takada-Takatori Y, Kume T, Sugimoto M, Katsuki H, Sugimoto H, Akaike A (2006) Acetylcholinesterase inhibitors used in treatment of Alzheimer\u2019s disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade. Neuropharmacology 51:474\u2013486","journal-title":"Neuropharmacology"},{"key":"2841_CR43","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neulet.2009.07.024","volume":"462","author":"K Tanaka","year":"2009","unstructured":"Tanaka K, Yagi T, Shimakoshi R, Azuma K, Nanba T, Ogo H, Tamura A, Asanuma M (2009) Effects of galantamine on L-NAME-induced behavioral impairment in Y-maze task in mice. Neurosci Lett 462:235\u2013238","journal-title":"Neurosci Lett"},{"key":"2841_CR44","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1517\/13543784.16.12.1987","volume":"16","author":"M Villarroya","year":"2007","unstructured":"Villarroya M, Garc\u00eda AG, Marco-Contelles J, L\u00f3pez MG (2007) An update on the pharmacology of galantamine. Expert Opin Investig Drugs 16:1987\u20131998","journal-title":"Expert Opin Investig Drugs"},{"key":"2841_CR45","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1017\/S1461145710000921","volume":"14","author":"ML Wadenberg","year":"2011","unstructured":"Wadenberg ML, Fj\u00e4llstr\u00f6m AK, Federley M, Persson P, Stenqvist P (2011) Effects of adjunct galantamine to risperidone, or haloperidol, in animal models of antipsychotic activity and extrapyramidal side-effect liability: involvement of the cholinergic muscarinic receptor. Int J Neuropsychopharmacol 14:644\u2013654","journal-title":"Int J Neuropsychopharmacol"},{"key":"2841_CR46","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/sj.npp.1301256","volume":"32","author":"D Wang","year":"2007","unstructured":"Wang D, Noda Y, Zhou Y, Mouri A, Mizoguchi H, Nitta A, Chen W, Nabeshima T (2007) The allosteric potentiation of nicotinic acetylcholine receptors by galantamine ameliorates the cognitive dysfunction in beta amyloid25\u201335 i.c.v.-injected mice: involvement of dopaminergic systems. Neuropsychopharmacology 32:1261\u20131271","journal-title":"Neuropsychopharmacology"},{"key":"2841_CR47","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1021\/jm0602413","volume":"49","author":"DG Wishka","year":"2006","unstructured":"Wishka DG, Walker DP, Yates KM, Reitz SC, Jia S, Myers JK, Olson KL, Jacobsen EJ, Wolfe ML, Groppi VE, Hanchar AJ, Thornburgh BA, Cortes-Burgos LA, Wong EH, Staton BA, Raub TJ, Higdon NR, Wall TM, Hurst RS, Walters RR, Hoffmann WE, Hajos M, Franklin S, Carey G, Gold LH, Cook KK, Sands SB, Zhao SX, Soglia JR, Kalgutkar AS, Arneric SP, Rogers BN (2006) Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the \u03b17 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure\u2013activity relationship. J Med Chem 49:4425\u20134436","journal-title":"J Med Chem"},{"key":"2841_CR48","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/j.1476-5381.2008.00037.x","volume":"156","author":"K Yano","year":"2009","unstructured":"Yano K, Koda K, Ago Y, Kobayashi H, Kawasaki T, Takuma K, Matsuda T (2009) Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice. Br J Pharmacol 156:173\u2013180","journal-title":"Br J Pharmacol"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-012-2841-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-012-2841-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-012-2841-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T12:19:42Z","timestamp":1744028382000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-012-2841-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,30]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["2841"],"URL":"https:\/\/doi.org\/10.1007\/s00213-012-2841-7","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,30]]}}}