{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:11:52Z","timestamp":1790784712641,"version":"4.1.0"},"reference-count":104,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,9,16]],"date-time":"2012-09-16T00:00:00Z","timestamp":1347753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1007\/s00213-012-2845-3","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T07:51:40Z","timestamp":1347695500000},"page":"579-594","source":"Crossref","is-referenced-by-count":49,"title":["Enhancement of social novelty discrimination by positive allosteric modulators at metabotropic glutamate 5 receptors: adolescent administration prevents adult-onset deficits induced by neonatal treatment with phencyclidine"],"prefix":"10.1007","volume":"225","author":[{"given":"Nicholas E.","family":"Clifton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nad\u00e8ge","family":"Morisot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Girardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Millan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Loiseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,9,16]]},"reference":[{"key":"2845_CR1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1749-6632.2010.05445.x","volume":"1191","author":"R Adolphs","year":"2010","unstructured":"Adolphs R (2010) What does the amygdala contribute to social cognition? Ann N Y Acad Sci 1191:42\u201361","journal-title":"Ann N Y Acad Sci"},{"key":"2845_CR2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neuropharm.2005.05.005","volume":"49","author":"S Alagarsamy","year":"2005","unstructured":"Alagarsamy S, Saugstad J, Warren L, Mansuy IM, Gereau RW, Conn PJ (2005) NMDA-induced potentiation of mGluR5 is mediated by activation of protein phosphatase 2B\/calcineurin. Neuropharmacology 49:135\u2013145","journal-title":"Neuropharmacology"},{"key":"2845_CR3","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/sj.cdd.4400678","volume":"7","author":"JW Allen","year":"2000","unstructured":"Allen JW, Knoblach SM, Faden AI (2000) Activation of group I metabotropic glutamate receptors reduces neuronal apoptosis but increases necrotic cell death in vitro. Cell Death Differ 7:470\u2013476","journal-title":"Cell Death Differ"},{"key":"2845_CR4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.biopsych.2010.03.004","volume":"68","author":"N Amitai","year":"2010","unstructured":"Amitai N, Markou A (2010) Disruption of performance in the five-choice serial reaction time task induced by administration of N-methyl-D-aspartate receptor antagonists: relevance to cognitive dysfunction in schizophrenia. Biol Psychiatry 68:5\u201316","journal-title":"Biol Psychiatry"},{"key":"2845_CR5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1001\/archgenpsychiatry.2009.192","volume":"67","author":"GP Amminger","year":"2010","unstructured":"Amminger GP, Sch\u00e4fer MR, Papageorgiou K, Klier CM, Cotton SM, Harrigan SM et al (2010) Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psychiatry 67:146\u2013154","journal-title":"Arch Gen Psychiatry"},{"key":"2845_CR6","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/sj.npp.1300394","volume":"29","author":"JD Andersen","year":"2004","unstructured":"Andersen JD, Pouzet B (2004) Spatial memory deficits induced by perinatal treatment of rats with PCP and reversal effect of D-serine. Neuropsychopharmacology 29:1080\u20131090","journal-title":"Neuropsychopharmacology"},{"key":"2845_CR7","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1523\/JNEUROSCI.20-21-07871.2000","volume":"20","author":"H Awad","year":"2000","unstructured":"Awad H, Hubert GW, Smith Y, Levey AI, Conn PJ (2000) Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus. J Neurosci 20:7871\u20137879","journal-title":"J Neurosci"},{"key":"2845_CR8","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/npp.2009.30","volume":"34","author":"JE Ayala","year":"2009","unstructured":"Ayala JE, Chen Y, Banko JL, Sheffler DJ, Williams R, Telk AN, Watson NL et al (2009) mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning. Neuropsychopharmacology 34:2057\u20132071","journal-title":"Neuropsychopharmacology"},{"key":"2845_CR9","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.bbr.2009.06.018","volume":"205","author":"PC Baier","year":"2009","unstructured":"Baier PC, Blume A, Koch J, Marx A, Fritzer G, Aldenhoff JB et al (2009) Early postnatal depletion of NMDA receptor development affects behaviour and NMDA receptor expression until later adulthood in rats\u2013a possible model for schizophrenia. Behav Brain Res 205:96\u2013101","journal-title":"Behav Brain Res"},{"key":"2845_CR10","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.neuroscience.2006.06.043","volume":"142","author":"D Balschun","year":"2006","unstructured":"Balschun D, Zuschratter W, Wetzel W (2006) Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory. Neuroscience 142:691\u2013702","journal-title":"Neuroscience"},{"key":"2845_CR11","doi-asserted-by":"crossref","first-page":"e9755","DOI":"10.1371\/journal.pone.0009755","volume":"5","author":"F Bertaso","year":"2010","unstructured":"Bertaso F, Roussignol G, Worley P, Bockaert J, Fagni L, Ango F (2010) Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons. PLoS One 5:e9755","journal-title":"PLoS One"},{"key":"2845_CR12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev-neuro-060909-153138","volume":"35","author":"AL Bhakar","year":"2012","unstructured":"Bhakar AL, D\u00f6len G, Bear MF (2012) The pathophysiology of fragile X (and what it teaches us about synapses). Annu Rev Neurosci 35:417\u2013443","journal-title":"Annu Rev Neurosci"},{"key":"2845_CR13","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pbb.2008.06.009","volume":"91","author":"D Boulay","year":"2008","unstructured":"Boulay D, Pichat P, Dargazanli G, Estenne-Bouhtou G, Terranova JP, Rogacki N et al (2008) Characterization of SSR103800, a selective inhibitor of the glycine transporter-1 in models predictive of therapeutic activity in schizophrenia. Pharmacol Biochem Behav 91:47\u201358","journal-title":"Pharmacol Biochem Behav"},{"key":"2845_CR14","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/sj.mp.4001404","volume":"9","author":"SA Brody","year":"2004","unstructured":"Brody SA, Dulawa SC, Conquet F, Geyer MA (2004) Assessment of a prepulse inhibition deficit in a mutant mouse lacking mGlu5 receptors. Mol Psychiatry 9:35\u201341","journal-title":"Mol. Psychiatry"},{"key":"2845_CR15","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/glia.20783","volume":"57","author":"KR Byrnes","year":"2009","unstructured":"Byrnes KR, Stoica B, Loane DJ, Riccio A, Davis MI, Faden AI (2009) Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity. Glia 57:550\u2013560","journal-title":"Glia"},{"key":"2845_CR16","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1080\/10408440802026307","volume":"38","author":"EJ Calabrese","year":"2008","unstructured":"Calabrese EJ (2008) U-shaped dose response in behavioral pharmacology: historical foundations. Crit Rev Toxicol 38:591\u2013598","journal-title":"Crit Rev Toxicol"},{"key":"2845_CR17","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s00213-004-1827-5","volume":"175","author":"UC Campbell","year":"2004","unstructured":"Campbell UC, Lalwani K, Hernandez L, Kinney GG, Conn PJ, Bristow LJ (2004) The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats. Psychopharmacology 175:310\u2013318","journal-title":"Psychopharmacology"},{"key":"2845_CR18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00213-008-1103-1","volume":"198","author":"MH Chan","year":"2008","unstructured":"Chan MH, Chiu PH, Sou JH, Chen HH (2008) Attenuation of ketamine-evoked behavioral responses by mGluR5 positive modulators in mice. Psychopharmacology 198:141\u2013148","journal-title":"Psychopharmacology"},{"key":"2845_CR19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1423-0127-18-19","volume":"18","author":"HH Chen","year":"2011","unstructured":"Chen HH, Liao PF, Chan MH (2011) mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway. J Biomed Sci 18:19","journal-title":"J Biomed Sci"},{"key":"2845_CR20","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1124\/mol.106.032425","volume":"71","author":"Y Chen","year":"2007","unstructured":"Chen Y, Nong Y, Goudet C, Hemstapat K, de Paulis T, Pin JP et al (2007) Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Mol Pharmacol 71:1389\u20131398","journal-title":"Mol Pharmacol"},{"key":"2845_CR21","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.neulet.2005.10.072","volume":"394","author":"ES Choe","year":"2006","unstructured":"Choe ES, Shin EH, Wang JQ (2006) Regulation of phosphorylation of NMDA receptor NR1 subunits in the rat neostriatum by group I metabotropic glutamate receptors in vivo. Neurosci Lett 394:246\u2013251","journal-title":"Neurosci Lett"},{"key":"2845_CR22","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bbr.2008.03.032","volume":"191","author":"GR Christoffersen","year":"2008","unstructured":"Christoffersen GR, Simonyi A, Schachtman TR, Clausen B, Clement D, Bjerre VK et al (2008) MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in rats. Behav Brain Res 191:235\u2013245","journal-title":"Behav Brain Res"},{"key":"2845_CR23","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1038\/sj.npp.1300490","volume":"29","author":"Y Chudasama","year":"2004","unstructured":"Chudasama Y, Robbins TW (2004) Dopaminergic modulation of visual attention and working memory in the rodent prefrontal cortex. Neuropsychopharmacology 29:1628\u20131636","journal-title":"Neuropsychopharmacology"},{"key":"2845_CR24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0306-4522(01)00171-3","volume":"105","author":"B Clancy","year":"2001","unstructured":"Clancy B, Darlington RB, Finlay BL (2001) Translating developmental time across mammalian species. Neuroscience 105:7\u201317","journal-title":"Neuroscience"},{"key":"2845_CR25","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.3390\/molecules16032097","volume":"16","author":"RM Cleva","year":"2011","unstructured":"Cleva RM, Olive MF (2011) Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders. Molecules 16:2097\u20132106","journal-title":"Molecules"},{"key":"2845_CR26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/FBP.0b013e3282feb0ac","volume":"19","author":"JM Darrah","year":"2008","unstructured":"Darrah JM, Stefani MR, Moghaddam B (2008) Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm. Behav Pharmacol 19:225\u2013234","journal-title":"Behav Pharmacol"},{"key":"2845_CR27","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1038\/sj.npp.1300772","volume":"30","author":"R Depoort\u00e8re","year":"2005","unstructured":"Depoort\u00e8re R, Dargazanli G, Estenne-Bouhtou G, Coste A, Lanneau C, Desvignes C et al (2005) Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic. Neuropsychopharmacology 30:1963\u20131985","journal-title":"Neuropsychopharmacology"},{"key":"2845_CR28","doi-asserted-by":"crossref","first-page":"7751","DOI":"10.1073\/pnas.0307850101","volume":"101","author":"M Deng","year":"2004","unstructured":"Deng M, Wang H, Rosenberg PA, Volpe JJ, Jensen FE (2004) Role of metabotropic glutamate receptors in oligodendrocytes excitotoxicity and oxidative stress. Proc Natl Acad Sci USA 101:7751\u20137756","journal-title":"Proc Natl Acad Sci USA"},{"key":"2845_CR29","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1007\/s00406-011-0244-0","volume":"261","author":"B Derntl","year":"2011","unstructured":"Derntl B, Habel U (2011) Deficits in social cognition: a marker for psychiatric disorders? Eur Arch Psychiatry Clin Neurosci 261:S145\u2013S149","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"2845_CR30","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.pharmthera.2010.02.008","volume":"127","author":"G D\u00f6len","year":"2010","unstructured":"D\u00f6len G, Carpenter RL, Ocain TD, Bear MF (2010) Mechanism-based approaches to treating fragile X. Pharmacol Ther 127:78\u201393","journal-title":"Pharmacol Ther"},{"key":"2845_CR31","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.euroneuro.2008.12.002","volume":"19","author":"TM Bois du","year":"2009","unstructured":"du Bois TM, Deng C, Han M, Newell KA, Huang XF (2009) Excitatory and inhibitory neurotransmission is chronically altered following perinatal NMDA receptor blockade. Eur Neuropsychopharmacol 19:256\u2013265","journal-title":"Eur Neuropsychopharmacol"},{"key":"2845_CR32","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0031-9384(95)00053-L","volume":"58","author":"M Engelmann","year":"1995","unstructured":"Engelmann M, Wotjak CT, Landgraf R (1995) Social discrimination procedure: an alternative method to investigate juvenile recognition abilities in rats. Physiol Behav 58:315\u2013321","journal-title":"Physiol Behav"},{"key":"2845_CR33","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1006\/frne.2002.0229","volume":"23","author":"JN Ferguson","year":"2002","unstructured":"Ferguson JN, Young LJ, Insel TR (2002) The neuroendocrine basis of social recognition. Front Neuroendocrinol 23:200\u2013224","journal-title":"Front Neuroendocrinol"},{"key":"2845_CR34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.nlm.2010.11.009","volume":"95","author":"SW Fowler","year":"2010","unstructured":"Fowler SW, Ramsey AK, Walker JM, Serfozo P, Olive MF, Schachtman TR et al (2010) Functional interaction of mGlu5 and NMDA receptors in aversive learning in rats. Neurobiol Learn Mem 95:73\u201379","journal-title":"Neurobiol Learn Mem"},{"key":"2845_CR35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bbr.2003.12.026","volume":"153","author":"A Fredriksson","year":"2004","unstructured":"Fredriksson A, Archer T, Alm H, Gordh T, Eriksson P (2004) Neurofunctional deficits and potentiated apoptosis by neonatal NMDA antagonist administration. Behav Brain Res 153:367\u2013376","journal-title":"Behav Brain Res"},{"key":"2845_CR36","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1176\/ajp.152.2.208","volume":"152","author":"P Gorwood","year":"1995","unstructured":"Gorwood P, Leboyer M, Jay M, Payan C, Feingold J (1995) Gender and age at onset in schizophrenia: impact of family history. Am J Psychiatry 152:208\u2013212","journal-title":"Am J Psychiatry"},{"key":"2845_CR37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/syn.20164","volume":"57","author":"DS Gupta","year":"2005","unstructured":"Gupta DS, McCullumsmith RE, Beneyto M, Haroutunian V, Davis KL, Meador-Woodruff JH (2005) Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia. Synapse 57:123\u2013131","journal-title":"Synapse"},{"key":"2845_CR38","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00213-007-0742-y","volume":"192","author":"S Harich","year":"2007","unstructured":"Harich S, Gross G, Bespalov A (2007) Stimulation of the metabotropic glutamate 2\/3 receptor attenuates social novelty discrimination deficits induced by neonatal phencyclidine treatment. Psychopharmacology 192:511\u2013519","journal-title":"Psychopharmacology"},{"key":"2845_CR39","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1046\/j.1460-9568.2003.02902.x","volume":"18","author":"LW Harris","year":"2003","unstructured":"Harris LW, Sharp T, Gartlon J, Jones DNC, Harrison PJ (2003) Long-term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism. Eur J Neurosci 18:1706\u20131710","journal-title":"Eur J Neurosci"},{"key":"2845_CR40","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.tics.2010.12.005","volume":"15","author":"TF Heatherton","year":"2011","unstructured":"Heatherton TF, Wagner DD (2011) Cognitive neuroscience of self-regulation failure. Trends Cogn Sci 15:132\u2013139","journal-title":"Trends Cogn Sci"},{"key":"2845_CR41","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1038\/sj.npp.1300417","volume":"29","author":"H Homayoun","year":"2004","unstructured":"Homayoun H, Stefani MR, Adams BW, Tamagan GD, Moghaddam B (2004) Functional interaction between NMDA and mGlu5 Receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release. Neuropsychopharmacology 29:1259\u20131269","journal-title":"Neuropsychopharmacology"},{"key":"2845_CR42","doi-asserted-by":"crossref","unstructured":"Horio M, Fujita Y, Hashimoto K (2012) Therapeutic effects of metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice. Fundam Clin Pharmacol. doi: 10.1111\/j.1472-8206.2012.01045.x.","DOI":"10.1111\/j.1472-8206.2012.01045.x"},{"key":"2845_CR43","first-page":"4","volume":"47","author":"DC Javitt","year":"2010","unstructured":"Javitt DC (2010) Glutamatergic theories of schizophrenia. Isr J Psychiatry Relat Sci 47:4\u201316","journal-title":"Isr J Psychiatry Relat Sci"},{"key":"2845_CR44","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1124\/jpet.103.048702","volume":"306","author":"GG Kinney","year":"2003","unstructured":"Kinney GG, Burno M, Campbell UC, Hernandez LM, Rodriguez D, Bristow LJ et al (2003) Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents. J Pharmacol Exp Ther 306:116\u2013123","journal-title":"J Pharmacol Exp Ther"},{"key":"2845_CR45","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1124\/jpet.104.079244","volume":"313","author":"GG Kinney","year":"2005","unstructured":"Kinney GG, O\u2019Brien JA, Lemaire W, Burno M, Bickel DJ, Clements MK et al (2005) A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models. J Pharmacol Exp Ther 313:199\u2013206","journal-title":"J Pharmacol Exp Ther"},{"key":"2845_CR46","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1358\/dnp.2003.16.8.829350","volume":"16","author":"PM Lea","year":"2003","unstructured":"Lea PM, Faden AI (2003) Modulation of metabotropic glutamate receptors as potential treatment for acute and chronic neurodegenerative disorders. Drug news Perspect 16:513\u2013522","journal-title":"Drug news Perspect"},{"key":"2845_CR47","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.biopsych.2006.12.003","volume":"62","author":"L Lecourtier","year":"2007","unstructured":"Lecourtier L, Homayoun H, Tamagnan G, Moghaddam B (2007) Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex. Biol Psychiatry 62:739\u2013746","journal-title":"Biol Psychiatry"},{"key":"2845_CR48","first-page":"427","volume":"58","author":"B Legutko","year":"2006","unstructured":"Legutko B, Szewczyk B, Pomierny-Chamiolo L, Nowak G, Pilc A (2006) Effect of MPEP treatment on brain-derived neurotrophic factor gene expression. Pharmacol Rep 58:427\u2013430","journal-title":"Pharmacol Rep"},{"key":"2845_CR49","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4088\/JCP.08m04666yel","volume":"71","author":"Y Levkovitz","year":"2010","unstructured":"Levkovitz Y, Mendlovich S, Riwkes S, Braw Y, Levkovitch-Verbin H, Gal G et al (2010) A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia. J Clin Psychiatry 71:138\u2013149","journal-title":"J Clin Psychiatry"},{"key":"2845_CR50","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1093\/schbul\/sbr066","volume":"37","author":"TM Lincoln","year":"2011","unstructured":"Lincoln TM, Mehl S, Kesting ML, Rief W (2011) Negative symptoms and social cognition: identifying targets for psychological interventions. Schizophr Bull 37:S23\u2013S32","journal-title":"Schizophr Bull"},{"key":"2845_CR51","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.1021\/jm049400d","volume":"47","author":"CW Lindsley","year":"2004","unstructured":"Lindsley CW, Wisnoski DD, Leister WH, O\u2019Brien JA, Lemaire W, Williams DL et al (2004) Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1\u00a0H-pyrazol-5-yl)benzamides that potentiate receptor function in vivo. J Med Chem 47:5825\u20135828","journal-title":"J Med Chem"},{"key":"2845_CR52","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/npp.1993.44","volume":"9","author":"BK Lipska","year":"1993","unstructured":"Lipska BK, Jaskiw GE, Weinberger DR (1993) Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: a potential animal model of schizophrenia. Neuropsychopharmacology 9:67\u201375","journal-title":"Neuropsychopharmacology"},{"key":"2845_CR53","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF02246439","volume":"122","author":"BK Lipska","year":"1995","unstructured":"Lipska BK, Swerdlow NR, Geyer MA, Jaskiw GE, Braff DL, Weinberger DR (1995) Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine. Psychopharmacology 122:35\u201343","journal-title":"Psychopharmacology"},{"key":"2845_CR54","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1124\/jpet.108.136580","volume":"327","author":"F Liu","year":"2008","unstructured":"Liu F, Grauer S, Kelley C, Navarra R, Graf R, Zhang G et al (2008) ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J Pharm Exp Ther 327:827\u2013839","journal-title":"J Pharm Exp Ther"},{"key":"2845_CR55","first-page":"S83","volume":"20","author":"F Loiseau","year":"2009","unstructured":"Loiseau F, Watson D, Girardon S, Fone K, Millan MJ (2009) Blockade of D3 but not D2 receptors improves novel object recognition and social novelty discrimination in rats. Behav Pharmacol 20:S83","journal-title":"Behav Pharmacol"},{"key":"2845_CR56","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1523\/JNEUROSCI.17-13-05196.1997","volume":"17","author":"YM Lu","year":"1997","unstructured":"Lu YM, Jia Z, Janus C, Henderson JT, Gerlai R, Wojtowicz JM et al (1997) Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci 17:5196\u20135205","journal-title":"J Neurosci"},{"key":"2845_CR57","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/j.1471-4159.2006.04103.x","volume":"99","author":"K Luyt","year":"2006","unstructured":"Luyt K, V\u00e1radi A, Durant CF, Moln\u00e1r E (2006) Oligodendroglial metabotropic glutamate receptors are developmentally regulated and involved in the prevention of apoptosis. J Neurochem 99:641\u2013656","journal-title":"J Neurochem"},{"key":"2845_CR58","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1093\/cercor\/bhi047","volume":"15","author":"D Manahan-Vaughan","year":"2005","unstructured":"Manahan-Vaughan D, Braunewell KH (2005) The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity. Cereb Cortex 15:1703\u20131713","journal-title":"Cereb Cortex"},{"key":"2845_CR59","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1001\/archpsyc.59.10.921","volume":"59","author":"PD McGorry","year":"2002","unstructured":"McGorry PD, Yung AR, Phillips LJ, Yuen HP, Francey S, Cosgrave EM et al (2002) Randomized controlled trial of interventions designed to reduce the risk of progression to first-episode psychosis in a clinical sample with subthreshold symptoms. Arch Gen Psychiatry 59:921\u2013928","journal-title":"Arch Gen Psychiatry"},{"key":"2845_CR60","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00213-009-1754-6","volume":"208","author":"U Meyer","year":"2010","unstructured":"Meyer U, Knuesel I, Nyffeler M, Feldon J (2010) Chronic clozapine treatment improves prenatal infection-induced working memory deficits without influencing adult hippocampal neurogenesis. Psychopharmacology 208:531\u2013543","journal-title":"Psychopharmacology"},{"key":"2845_CR61","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00213-005-2199-1","volume":"179","author":"MJ Millan","year":"2005","unstructured":"Millan MJ (2005) N-Methyl-D-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives. Psychopharmacology 179:30\u201353","journal-title":"Psychopharmacology"},{"key":"2845_CR62","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrd3628","volume":"11","author":"MJ Millan","year":"2012","unstructured":"Millan MJ, Agid Y, Br\u00fcne M, Bullmore ET, Carter CS, Clayton NS et al (2012) Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov 11:141\u2013168","journal-title":"Nat Rev Drug Discov"},{"key":"2845_CR63","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1046\/j.1460-9568.2000.00189.x","volume":"12","author":"B Monti","year":"2000","unstructured":"Monti B, Contestabile A (2000) Blockade of the NMDA receptor increases developmental apoptotic elimination of granule neurons and activates caspases in the rat cerebellum. Eur J Neurosci 12:3117\u20133123","journal-title":"Eur J Neurosci"},{"key":"2845_CR64","first-page":"15","volume":"506","author":"N Morisot","year":"2010","unstructured":"Morisot N, Girardon S, Millan MJ, Loiseau F (2010) The metabotropic mGlu5 receptor positive allosteric modulator, CDPPB, enhances social discrimination in a developmental model of schizophrenia, neonatal phencyclidine-treated rats. 40th annual meeting Society for Neurosciences 506:15","journal-title":"40th annual meeting Society for Neurosciences"},{"key":"2845_CR65","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.neuint.2007.06.019","volume":"51","author":"A Mouri","year":"2007","unstructured":"Mouri A, Noda Y, Enomoto T, Nabeshima T (2007) Phencyclidine animal models of schizophrenia: approaches from abnormality of glutamatergic neurotransmission and neurodevelopment. Neurochem Int 51:173\u2013184","journal-title":"Neurochem Int"},{"key":"2845_CR66","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1111\/j.1471-4159.2004.02451.x","volume":"89","author":"VA Movsesyan","year":"2004","unstructured":"Movsesyan VA, Stoica BA, Faden AI (2004) MGluR5 activation reduces beta-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor. J Neurochem 89:1528\u20131536","journal-title":"J Neurochem"},{"key":"2845_CR67","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1248\/bpb.32.1576","volume":"32","author":"A Nakatani-Pawlak","year":"2009","unstructured":"Nakatani-Pawlak A, Yamaguchi K, Tatsumi Y, Mizoguchi H, Yoneda Y (2009) Neonatal phencyclidine treatment in mice induces behavioral, histological and neurochemical abnormalities in adulthood. Biol Pharm Bull 32:1576\u20131583","journal-title":"Biol Pharm Bull"},{"key":"2845_CR68","doi-asserted-by":"crossref","unstructured":"Neyman S, Manahan-Vaughan D (2008) Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro. Eur J Neurosci 27:1345\u20131352","DOI":"10.1111\/j.1460-9568.2008.06109.x"},{"key":"2845_CR69","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.neuropharm.2010.10.022","volume":"60","author":"F Nicoletti","year":"2010","unstructured":"Nicoletti F, Bockaert J, Collingridge GL, Conn PJ, Ferraguti F, Schoepp DD et al (2010) Metabotropic glutamate receptors: from the workbench to the bedside. Neuropharmacology 60:1017\u20131041","journal-title":"Neuropharmacology"},{"key":"2845_CR70","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.pharmtox.011008.145533","volume":"50","author":"CM Niswender","year":"2010","unstructured":"Niswender CM, Conn PJ (2010) Metabotropic glutamate receptors: physiology, pharmacology, and disease. Annu Rev Pharmacol Toxicol 50:295\u2013322","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2845_CR71","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.biopsych.2005.07.031","volume":"59","author":"K Ozawa","year":"2006","unstructured":"Ozawa K, Hashimoto K, Kishimoto T, Shimizu E, Ishikura H, Iyo M (2006) Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia. Biol Psychiatry 59:546\u2013554","journal-title":"Biol Psychiatry"},{"key":"2845_CR72","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1101\/lm.8.2.96","volume":"8","author":"MG Packard","year":"2001","unstructured":"Packard MG, Vecchioli SF, Schroeder JP, Gasbarri A (2001) Task-dependent role for dorsal striatum metabotropic glutamate receptors in memory. Learn Mem 8:96\u2013103","journal-title":"Learn Mem"},{"key":"2845_CR73","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.neuint.2006.01.020","volume":"49","author":"G Page","year":"2006","unstructured":"Page G, Khidir FA, Pain S, Barrier L, Fauconneau B, Guillard O et al (2006) Group I metabotropic glutamate receptors activate the p70S6 kinase via both mammalian target of rapamycin (mTOR) and extracellular signal-regulated kinase (ERK 1\/2) signaling pathways in rat striatal and hippocampal synaptoneurosomes. Neurochem Int 49:413\u2013421","journal-title":"Neurochem Int"},{"key":"2845_CR74","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/S0028-3908(97)00181-0","volume":"36","author":"MJ Palmer","year":"1997","unstructured":"Palmer MJ, Irving AJ, Seabrook GR, Jane DE, Collingridge GL (1997) The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus. Neuropharmacology 36:1517\u20131532","journal-title":"Neuropharmacology"},{"key":"2845_CR75","unstructured":"Paxinos G, Watson C (1997) The Rat Brain in Stereotaxic Coordinates, 3rd edn. Academic Press, San Diego, p 402"},{"key":"2845_CR76","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/sj.npp.1301188","volume":"32","author":"P Pichat","year":"2007","unstructured":"Pichat P, Bergis OE, Terranova JP, Urani A, Duarte C, Santucci V et al (2007) SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology 32:17\u201334","journal-title":"Neuropsychopharmacology"},{"key":"2845_CR77","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.biopsych.2009.07.005","volume":"66","author":"Y Piontkewitz","year":"2009","unstructured":"Piontkewitz Y, Assaf Y, Weiner I (2009) Clozapine administration in adolescence prevents postpubertal emergence of brain structural pathology in an animal model of schizophrenia. Biol Psychiatry 66:1038\u20131046","journal-title":"Biol Psychiatry"},{"key":"2845_CR78","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/schbul\/sbq040","volume":"37","author":"Y Piontkewitz","year":"2010","unstructured":"Piontkewitz Y, Arad M, Weiner I (2010) Risperidone administered during asymptomatic period of adolescence prevents the emergence of brain structural pathology and behavioral abnormalities in an animal model of schizophrenia. Schizophr Bull 37:1257\u20131269","journal-title":"Schizophr Bull"},{"key":"2845_CR79","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.neuropharm.2007.05.023","volume":"53","author":"D Quarta","year":"2007","unstructured":"Quarta D, Naylor CG, Morris HV, Patel S, Genn RF, Stolerman IP (2007) Different effects of ionotropic and metabotropic glutamate receptor antagonists on attention and the attentional properties of nicotine. Neuropharmacology 53:421\u2013430","journal-title":"Neuropharmacology"},{"key":"2845_CR80","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00213-006-0584-z","volume":"190","author":"BA Rasmussen","year":"2007","unstructured":"Rasmussen BA, O\u2019Neil J, Manaye KF, Perry DC, Tizabi Y (2007) Long-term effects of developmental PCP administration on sensorimotor gating in male and female rats. Psychopharmacology 190:43\u201349","journal-title":"Psychopharmacology"},{"key":"2845_CR81","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/sj.npp.1301163","volume":"31","author":"NM Richtand","year":"2006","unstructured":"Richtand NM, Taylor B, Welge JA, Ahlbrand R, Ostrander MM, Burr J et al (2006) Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesions. Neuropsychopharmacology 31:77\u201389","journal-title":"Neuropsychopharmacology"},{"key":"2845_CR82","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1126\/stke.15pe6","volume":"1","author":"JA Ronesi","year":"2008","unstructured":"Ronesi JA, Huber KM (2008) Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse. Sci Signal 1:e6","journal-title":"Sci Signal"},{"key":"2845_CR83","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejphar.2010.02.057","volume":"639","author":"H Rosenbrock","year":"2010","unstructured":"Rosenbrock H, Kramer G, Hobson S, Koros E, Grundl M, Grauert M et al (2010) Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator. Eur J Pharmacol 639:40\u201346","journal-title":"Eur J Pharmacol"},{"key":"2845_CR84","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pbb.2009.12.002","volume":"95","author":"C Schlumberger","year":"2010","unstructured":"Schlumberger C, Pietraszek M, Gravius A, Danysz W (2010) Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia. Pharmacol Biochem Behav 95:23\u201330","journal-title":"Pharmacol Biochem Behav"},{"key":"2845_CR85","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bbr.2008.12.012","volume":"199","author":"T Secher","year":"2009","unstructured":"Secher T, Berezin V, Bock E, Glenthoj B (2009) Effect of an NCAM mimetic FGL on impairments in spatial learning and memory after neonatal phencyclidine treatments in rats. Behav Brain Res 199:288\u2013297","journal-title":"Behav Brain Res"},{"key":"2845_CR86","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3940(93)90227-C","volume":"163","author":"R Shigemoto","year":"1993","unstructured":"Shigemoto R, Nomura S, Ohishi H, Sugihara H, Nakanishi S, Mizuno N (1993) Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci Lett 163:53\u201357","journal-title":"Neurosci Lett"},{"key":"2845_CR87","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejphar.2009.12.039","volume":"639","author":"A Simonyi","year":"2010","unstructured":"Simonyi A, Schachtman TR, Christoffersen GRJ (2010) Metabotropic glutamate receptor subtype 5 antagonism in learning and memory. Eur J Pharmacol 639:17\u201325","journal-title":"Eur J Pharmacol"},{"key":"2845_CR88","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0169-328X(96)00051-4","volume":"40","author":"R Sircar","year":"1996","unstructured":"Sircar R, Follesa P, Ticku MK (1996) Postnatal phencyclidine treatment differentially regulates N-methyl-D-aspartate receptor subunit mRNA expression in developing rat cerebral cortex. Mol Brain Res 40:214\u2013220","journal-title":"Mol Brain Res"},{"key":"2845_CR89","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0736-5748(03)00026-1","volume":"21","author":"R Sircar","year":"2003","unstructured":"Sircar R (2003) Postnatal phencyclidine-induced deficit in adult water maze performance is associated with N-methyl-D-aspartate receptor upregulation. Int J Devl Neurosci 21:159\u2013167","journal-title":"Int J Devl Neurosci"},{"key":"2845_CR90","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.biopsych.2004.11.031","volume":"57","author":"MR Stefani","year":"2005","unstructured":"Stefani MR, Moghaddam B (2005) Transient N-methyl-D-aspartate receptor blockade in early development causes lasting cognitive deficits relevant to schizophrenia. Biol Psychiatry 57:433\u2013436","journal-title":"Biol Psychiatry"},{"key":"2845_CR91","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejphar.2010.01.028","volume":"639","author":"MR Stefani","year":"2010","unstructured":"Stefani MR, Moghaddam B (2010) Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockade. Eur J Pharmacol 639:26\u201332","journal-title":"Eur J Pharmacol"},{"key":"2845_CR92","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1471-4159.2006.04106.x","volume":"99","author":"M Takahashi","year":"2006","unstructured":"Takahashi M, Kakita A, Futamura T, Watanabe Y, Mizuno M, Sakimura K et al (2006) Sustained brain-derived neurotrophic factor up-regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine: comparison with adult treatment. J Neurochem 99:770\u2013780","journal-title":"J Neurochem"},{"key":"2845_CR93","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s00213-005-2268-5","volume":"181","author":"JP Terranova","year":"2005","unstructured":"Terranova JP, Chabot C, Barnouin MC, Perrault G, Depoortere R, Griebel G et al (2005) SSR181507, a dopamine D(2) receptor antagonist and 5-HT(1A) receptor agonist, alleviates disturbances of novelty discrimination in a social context in rats, a putative model of selective attention deficit. Psychopharmacology 181:134\u2013144","journal-title":"Psychopharmacology"},{"key":"2845_CR94","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.brainres.2010.07.013","volume":"1352","author":"T Uehara","year":"2010","unstructured":"Uehara T, Sumiyoshi T, Seo T, Matsuoka T, Itoh H, Suzuki M et al (2010) Neonatal exposure to MK-801, an N-methyl-D-aspartate receptor antagonist, enhances methamphetamine-induced locomotion and disrupts sensorimotor gating in pre-and postpubertal rats. Brain Res 1352:223\u2013230","journal-title":"Brain Res"},{"key":"2845_CR95","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.neuropharm.2009.07.022","volume":"57","author":"JM Uslaner","year":"2009","unstructured":"Uslaner JM, Parmentier-Batteur S, Flick RB, Surles NO, Lam JSH, McNaughton CH et al (2009) Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus. Neuropharmacology 57:531\u2013538","journal-title":"Neuropharmacology"},{"key":"2845_CR96","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ejphar.2009.11.067","volume":"639","author":"K Vales","year":"2010","unstructured":"Vales K, Svoboda J, Benkovicova K, Bubenikova-Valesova V, Stuchlik A (2010) The difference in effect of mGlu2\/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801. Eur J Pharmacol 639:91\u201398","journal-title":"Eur J Pharmacol"},{"key":"2845_CR97","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.pbb.2010.01.010","volume":"95","author":"JD Vardigan","year":"2010","unstructured":"Vardigan JD, Huszar SL, McNaughton CH, Hutson PH, Uslaner JM (2010) MK-801 produces a deficit in sucrose preference that is reversed by clozapine, D-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: relevance to negative symptoms associated with schizophrenia? Pharmacol Biochem Behav 95:223\u2013229","journal-title":"Pharmacol Biochem Behav"},{"key":"2845_CR98","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neulet.2009.10.020","volume":"467","author":"K Viwatpinyo","year":"2009","unstructured":"Viwatpinyo K, Chongthammakun S (2009) Activation of group I metabotropic glutamate receptors leads to brain-derived neurotrophic factor expression in rat C6 cells. Neurosci Lett 467:127\u2013130","journal-title":"Neurosci Lett"},{"key":"2845_CR99","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0306-4522(01)00384-0","volume":"107","author":"C Wang","year":"2001","unstructured":"Wang C, McInnis J, Ross-Sanchez M, Shinnick-Gallagher P, Wiley JL, Johnson KM (2001) Long-term behavioral and neurodegenerative effects of perinatal phencyclidine administration: implications for schizophrenia. Neuroscience 107:535\u2013550","journal-title":"Neuroscience"},{"key":"2845_CR100","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/npp.2011.254","volume":"37","author":"DJG Watson","year":"2012","unstructured":"Watson DJG, Loiseau F, Millan MJ, Marsden CA, Fone KCF (2012) Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex. Neuropsychopharmacology 37:770\u2013786","journal-title":"Neuropsychopharmacology"},{"key":"2845_CR101","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nature11208","volume":"486","author":"H Won","year":"2012","unstructured":"Won H, Lee HR, Gee HY, Mah W, Kim JI, Lee J et al (2012) Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function. Nature 486:261\u2013265","journal-title":"Nature"},{"key":"2845_CR102","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/npp.2011.12","volume":"36","author":"D Xi","year":"2011","unstructured":"Xi D, Li YC, Snyder MA, Gao RY, Adelman AE, Zhang W et al (2011) Group II metabotropic glutamate receptor agonist ameliorates MK801-induced dysfunction of NMDA receptor via the Akt\/GSK-3\u03b2 pathway in adult rat prefrontal cortex. Neuropsychopharmacology 36:1260\u20131274","journal-title":"Neuropsychopharmacology"},{"key":"2845_CR103","doi-asserted-by":"crossref","unstructured":"Zoghbi HY, Bear MF (2012) Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. Cold Spring Harb Perspect Biol 4: pii: a009886.","DOI":"10.1101\/cshperspect.a009886"},{"key":"2845_CR104","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1038\/sj.npp.1300248","volume":"28","author":"L Zuckerman","year":"2003","unstructured":"Zuckerman L, Rehavi M, Nachman R, Weiner I (2003) Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophrenia. Neuropsychopharmacology 28:1778\u20131789","journal-title":"Neuropsychopharmacology"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-012-2845-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-012-2845-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-012-2845-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T19:57:24Z","timestamp":1562183844000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-012-2845-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,16]]},"references-count":104,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["2845"],"URL":"https:\/\/doi.org\/10.1007\/s00213-012-2845-3","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717956701.793485429","asserted-by":"object"}]},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,16]]}}}