{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:22:08Z","timestamp":1791181328346,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,3,7]],"date-time":"2013-03-07T00:00:00Z","timestamp":1362614400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1007\/s00213-013-3028-6","type":"journal-article","created":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T00:34:05Z","timestamp":1362530045000},"page":"217-230","source":"Crossref","is-referenced-by-count":33,"title":["Effects of chronic social defeat stress on behavior and choline acetyltransferase, 78-kDa glucose-regulated protein, and CCAAT\/enhancer-binding protein (C\/EBP) homologous protein in adult mice"],"prefix":"10.1007","volume":"228","author":[{"given":"Tong","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Biao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma Shrestha","family":"Muna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarique Rajasaheb","family":"Bagalkot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Mei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Jung","family":"Chae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Chul","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,3,7]]},"reference":[{"key":"3028_CR1","unstructured":"American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. Washington, DC: American Psychiatric Association"},{"issue":"2","key":"3028_CR2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0306-4522(95)00056-O","volume":"67","author":"I Aubert","year":"1995","unstructured":"Aubert I, Rowe W, Meaney MJ, Gauthier S, Quirion R (1995) Cholinergic markers in aged cognitively impaired Long\u2013Evans rats. Neuroscience 67(2):277\u2013292","journal-title":"Neuroscience"},{"key":"3028_CR3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.vascn.2006.04.001","volume":"54","author":"V Bertaina-Anglade","year":"2006","unstructured":"Bertaina-Anglade V, Enjuanes E, Morillon D, Drieu la Rochelle C (2006) The object recognition task in rats and mice: a simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entity. J Pharmacol Toxicol Methods 54:99\u2013105","journal-title":"J Pharmacol Toxicol Methods"},{"key":"3028_CR4","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1126\/science.1120972","volume":"311","author":"O Berton","year":"2006","unstructured":"Berton O, McClung CA, Dileone RJ, Krishnan V, Renthal W, Russo SJ et al (2006) Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 311:864\u2013868","journal-title":"Science"},{"issue":"3","key":"3028_CR5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0893-133X(99)00091-3","volume":"22","author":"C Bown","year":"2000","unstructured":"Bown C, Wang JF, MacQueen G, Young LT (2000) Increased temporal cortex ER stress proteins in depressed subjects who died by suicide. Neuropsychopharmacology 22(3):327\u2013332","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"3028_CR6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neubiorev.2004.05.005","volume":"29","author":"B Buwalda","year":"2005","unstructured":"Buwalda B, Kole MH, Veenema AH, Huininga M, de Boer SF, Korte SM et al (2005) Long-term effects of social stress on brain and behavior: a focus on hippocampal functioning. Neurosci Biobehav Rev 29(1):83\u201397","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"3028_CR7","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1006\/nlme.1998.3857","volume":"70","author":"PJ Colombo","year":"1998","unstructured":"Colombo PJ, Gallagher M (1998) Individual differences in spatial memory and striatal ChAT activity among young and aged rats. Neurobiol Learn Mem 70(3):314\u2013327","journal-title":"Neurobiol Learn Mem"},{"key":"3028_CR8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","volume":"36","author":"R D\u2019Hooge","year":"2001","unstructured":"D\u2019Hooge R, De Deyn PP (2001) Applications of the Morris water maze in the study of learning and memory. Brain Res Brain Res Rev 36:60\u201390","journal-title":"Brain Res Brain Res Rev"},{"key":"3028_CR9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.pnpbp.2003.09.028","volume":"28","author":"W El Hage","year":"2004","unstructured":"El Hage W, Peronny S, Griebel G, Belzung C (2004) Impaired memory following predatory stress in mice is improved by fluoxetine. Prog Neuropsychopharmacol Biol Psychiatry 28:123\u2013128","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3028_CR10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","volume":"31","author":"A Ennaceur","year":"1988","unstructured":"Ennaceur A, Delacour J (1988) A new one-trial test for neurobiological studies of memory in rats. I: behavioral data. Behav Brain Res 31:47\u201359","journal-title":"Behav Brain Res"},{"key":"3028_CR11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/(SICI)1098-2795(199912)54:4<326::AID-MRD2>3.0.CO;2-3","volume":"54","author":"NC Fontanier-Razzaq","year":"1999","unstructured":"Fontanier-Razzaq NC, Hay SM, Rees WD (1999) Upregulation of CHOP-10 (gadd153) expression in the mouse blastocyst as a response to stress. Mol Reprod Dev 54:326\u2013332","journal-title":"Mol Reprod Dev"},{"key":"3028_CR12","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/0006-8993(78)90267-6","volume":"152","author":"Z Gottesfeld","year":"1978","unstructured":"Gottesfeld Z, Kvet\u0148ansk\u0177 KIJ, Jacobowitz DM (1978) Effects of repeated immobilization stress on glutamate decarboxylase and choline acetyltransferase in discrete brain regions. Brain Res 152:374\u2013378","journal-title":"Brain Res"},{"issue":"9","key":"3028_CR13","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/0024-3205(77)90437-4","volume":"20","author":"D Haubrich","year":"1977","unstructured":"Haubrich D, Chippendale T (1977) Regulation of acetylcholine synthesis in nervous tissue. Life Sci 20(9):1465\u20131478","journal-title":"Life Sci"},{"key":"3028_CR14","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4236\/pp.2011.21002","volume":"2","author":"M Ishisaka","year":"2011","unstructured":"Ishisaka M, Kudo T, Shimazawa M, Kakefuda K, Oyagi A, Hyakkoku K et al (2011) Restraint-induced expression of endoplasmic reticulum stress-related genes in the mouse brain. Pharmacology & Pharmacy 2:10\u201316","journal-title":"Pharmacology & Pharmacy"},{"issue":"4265","key":"3028_CR15","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1126\/science.982031","volume":"194","author":"D Jenden","year":"1976","unstructured":"Jenden D, Jope R, Weiler M (1976) Regulation of acetylcholine synthesis: does cytoplasmic acetylcholine control high affinity choline uptake? Science 194(4265):635\u2013637","journal-title":"Science"},{"key":"3028_CR16","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.ps.36.020185.002531","volume":"36","author":"RC Kessler","year":"1985","unstructured":"Kessler RC, Price RH, Wortman CB (1985) Social factors in psychopathology: stress, social support, and coping processes. Annu Rev Psychol 36:531\u2013572","journal-title":"Annu Rev Psychol"},{"key":"3028_CR17","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.bbi.2006.11.001","volume":"21","author":"SG Kinsey","year":"2007","unstructured":"Kinsey SG, Bailey MT, Sheridan JF, Padgett DA, Avitsur R (2007) Repeated social defeat causes increased anxiety-like behavior and alters splenocyte function in C57BL\/6 and CD-1 mice. Brain Behav Immun 21:458\u2013466","journal-title":"Brain Behav Immun"},{"key":"3028_CR18","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cell.2007.09.018","volume":"131","author":"V Krishnan","year":"2007","unstructured":"Krishnan V, Han MH, Graham DL, Berton O, Renthal W, Russo SJ et al (2007) Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131:391\u2013404","journal-title":"Cell"},{"issue":"8","key":"3028_CR19","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0968-0004(01)01908-9","volume":"26","author":"AS Lee","year":"2001","unstructured":"Lee AS (2001) The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem Sci 26(8):504\u2013510","journal-title":"Trends Biochem Sci"},{"key":"3028_CR20","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.neubiorev.2005.03.014","volume":"29","author":"E Malatynska","year":"2005","unstructured":"Malatynska E, Knapp RJ (2005) Dominant\u2013submissive behavior as model of mania and depression. Neurosci Biobehav Rev 29:715\u2013737","journal-title":"Neurosci Biobehav Rev"},{"key":"3028_CR21","first-page":"844","volume":"5","author":"S Maren","year":"2004","unstructured":"Maren S, Quirk GJ (2004) Neuronal signaling of fear memory. Nature 5:844\u2013852","journal-title":"Nature"},{"key":"3028_CR22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/excr.2001.5248","volume":"267","author":"EV Maytin","year":"2001","unstructured":"Maytin EV, Ubeda M, Lin JC, Habener JF (2001) Stress-inducible transcription factor CHOP\/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms. Exp Cell Res 267:193\u2013204","journal-title":"Exp Cell Res"},{"key":"3028_CR23","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/j.1471-4159.2004.02952.x","volume":"92","author":"N Naidoo","year":"2005","unstructured":"Naidoo N, Giang W, Galante RJ, Pack AI (2005) Sleep deprivation induces the unfolded protein response in mouse cerebral cortex. J Neurochem 92:1150\u20131157","journal-title":"J Neurochem"},{"key":"3028_CR24","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.biopsych.2005.09.018","volume":"59","author":"EJ Nestler","year":"2006","unstructured":"Nestler EJ, Carlezon WA (2006) The mesolimbic dopamine reward circuit in depression. Biol Psychiatry 59:1151\u20131159","journal-title":"Biol Psychiatry"},{"key":"3028_CR25","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1046\/j.1440-1827.1999.00977.x","volume":"49","author":"Y Oda","year":"1999","unstructured":"Oda Y (1999) Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system. Pathol Int 49:921\u2013937","journal-title":"Pathol Int"},{"key":"3028_CR26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4196\/kjpp.2010.14.6.371","volume":"14","author":"HJ Park","year":"2010","unstructured":"Park HJ, Shim HS, Kim KS, Lee HL, Hahm DH, Shim I (2010) Effects of glycyrrhizae radix on repeated restraint stress-induced neurochemical and behavioral responses. Korean J Physiol Pharmacol 14:371\u2013376","journal-title":"Korean J Physiol Pharmacol"},{"issue":"1","key":"3028_CR27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bbr.2010.07.014","volume":"216","author":"M Razzoli","year":"2010","unstructured":"Razzoli M, Carboni L, Andreoli M, Ballottari A, Arban R (2010) Different susceptibility to social stress of BalbC and C57BL6\/J mice. Behav Brain Res 216(1):100\u2013108","journal-title":"Behav Brain Res"},{"issue":"12","key":"3028_CR28","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/mp.2010.34","volume":"15","author":"RJ Schloesser","year":"2010","unstructured":"Schloesser RJ, Lehmann M, Martinowich K, Manji HK, Herkenham M (2010) Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress. Mol Psychiatry 15(12):1152\u20131163","journal-title":"Mol Psychiatry"},{"key":"3028_CR29","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nn1659","volume":"9","author":"NM Tsankova","year":"2006","unstructured":"Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ (2006) Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 9:519\u2013525","journal-title":"Nat Neurosci"},{"key":"3028_CR30","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0166-4328(00)00300-4","volume":"117","author":"JC Frijtag von","year":"2000","unstructured":"von Frijtag JC, Reijmers LG, van der Harst JE, Leus IE, Van den BR, Spruijt BM (2000) Defeat followed by individual hosing results in long-term impaired reward- and cognition-related behaviors in rats. Behav Brain Res 117:137\u2013146","journal-title":"Behav Brain Res"},{"key":"3028_CR31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF01930471","volume":"48","author":"ZZ Wahba","year":"1992","unstructured":"Wahba ZZ, Soliman KFA (1992) Effect of stress on choline acetyltransferase activity of the brain and the adrenal of the rat. Experientia 48:265\u2013268","journal-title":"Experientia"},{"key":"3028_CR32","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/0278-5846(90)90073-P","volume":"14","author":"AP West","year":"1990","unstructured":"West AP (1990) Neurobehavioral studies of forced swimming: the role of learning and memory in the forced swim test. Prog Neuropsychopharmacol Biol Psychiatry 14:863\u2013877","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3028_CR33","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1046\/j.1471-4159.1994.62051653.x","volume":"62","author":"D Wu","year":"1994","unstructured":"Wu D, Hersh LB (1994) Choline acetyltransferase: celebrating its fiftieth year. J Neurochem 62:1653\u20131663","journal-title":"J Neurochem"},{"issue":"3","key":"3028_CR34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1017\/S1461145710000945","volume":"14","author":"T Yu","year":"2011","unstructured":"Yu T, Guo M, Garza J, Rendon S, Sun XL, Zhang W et al (2011) Cognitive and neural correlates of depression-like behavior in socially defeated mice: an animal model of depression with cognitive dysfunction. Int J Neuropsychopharmacol 14(3):303\u2013317","journal-title":"Int J Neuropsychopharmacol"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-013-3028-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-013-3028-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-013-3028-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T16:12:46Z","timestamp":1558627966000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-013-3028-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,7]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["3028"],"URL":"https:\/\/doi.org\/10.1007\/s00213-013-3028-6","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,7]]}}}