{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:12:04Z","timestamp":1769155924336,"version":"3.49.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T00:00:00Z","timestamp":1376956800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1007\/s00213-013-3230-6","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T10:17:14Z","timestamp":1376907434000},"page":"231-242","source":"Crossref","is-referenced-by-count":11,"title":["Mining mouse behavior for patterns predicting psychiatric drug classification"],"prefix":"10.1007","volume":"231","author":[{"given":"Neri","family":"Kafkafi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl L.","family":"Mayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg I.","family":"Elmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,8,20]]},"reference":[{"key":"3230_CR1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nrd2217","volume":"6","author":"Y Agid","year":"2007","unstructured":"Agid Y, Buzs\u00e1ki G, Diamond DM, Frackowiak R, Giedd J, Girault JA, Grace A, Lambert JJ, Manji H, Mayberg H, Popoli M, Prochiantz A, Richter-Levin G, Somogyi P, Spedding M, Svenningsson P, Weinberger D (2007) How can drug discovery for psychiatric disorders be improved? Nat Rev Drug Discov 6:189\u2013201. doi: 10.1038\/nrd2217","journal-title":"Nat Rev Drug Discov"},{"key":"3230_CR2","doi-asserted-by":"crossref","unstructured":"Benjamini Y, Yekutieli D (2005) False discovery rate-adjusted multiple confidence intervals for selected parameters. J Am Stat Assoc 100:71. doi: 10.1198\/016214504000001907","DOI":"10.1198\/016214504000001907"},{"issue":"8","key":"3230_CR3","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.neubiorev.2010.04.004","volume":"34","author":"Y Benjamini","year":"2010","unstructured":"Benjamini Y, Lipkind D, Horev G, Fonio E, Kafkafi N, Golani I (2010) Ten ways to improve the quality of descriptions of whole-animal movement. Neurosci Biobehav Rev 34(8):1351\u20131365. doi: 10.1016\/j.neubiorev.2010.04.004","journal-title":"Neurosci Biobehav Rev"},{"key":"3230_CR4","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1476-5381.2009.00230.x","volume":"157","author":"D Braida","year":"2009","unstructured":"Braida D et al (2009) Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents. Br J Pharmacol 157:844\u2013853","journal-title":"Br J Pharmacol"},{"key":"3230_CR5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00213-002-1179-y","volume":"164","author":"DC Broom","year":"2002","unstructured":"Broom DC et al (2002) Convulsant activity of a non-peptidic delta-opioid receptor agonist is not required for its antidepressant-like effects in Sprague\u2013Dawley rats. Psychopharmacology (Berlin) 164:42\u201348","journal-title":"Psychopharmacology (Berlin)"},{"issue":"18 Suppl","key":"3230_CR6","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1016\/S1359-6446(02)02423-6","volume":"7","author":"D Brunner","year":"2002","unstructured":"Brunner D, Nestler E, Leahy E (2002) In need of high-throughput behavioral systems. Drug Discov Today 7(18 Suppl):S107\u2013S112. doi: 10.1016\/S1359-6446(02)02423-6","journal-title":"Drug Discov Today"},{"key":"3230_CR7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1124\/jpet.105.092304","volume":"316","author":"WA Carlezon Jr","year":"2006","unstructured":"Carlezon WA Jr et al (2006) Depressive-like effects of the kappa-opioid receptor agonist salvinorin A on behavior and neurochemistry in rats. J Pharmacol Exp Ther 316:440\u2013447","journal-title":"J Pharmacol Exp Ther"},{"key":"3230_CR8","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1038\/sj.npp.1301638","volume":"33","author":"PJ Conn","year":"2008","unstructured":"Conn PJ, Roth BL (2008) Opportunities and challenges of psychiatric drug discovery: roles for scientists in academic, industry, and government settings. Neuropsychopharmacology 33:2048\u20132060. doi: 10.1038\/sj.npp.1301638","journal-title":"Neuropsychopharmacology"},{"issue":"Suppl 3","key":"3230_CR9","first-page":"27","volume":"57","author":"W Coryell","year":"1996","unstructured":"Coryell W (1996) Psychotic depression. J Clin Psychiatry 57(Suppl 3):27\u201331, discussion 49","journal-title":"J Clin Psychiatry"},{"key":"3230_CR10","doi-asserted-by":"crossref","DOI":"10.1002\/0470119055","volume-title":"What's wrong with my mouse?: behavioral phenotyping of transgenic and knockout mice","author":"JN Crawley","year":"2007","unstructured":"Crawley JN (2007) What's wrong with my mouse?: behavioral phenotyping of transgenic and knockout mice, 2nd edn. Wiley, Chichester","edition":"2"},{"key":"3230_CR11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00213-005-0166-5","volume":"183","author":"JJ Crowley","year":"2005","unstructured":"Crowley JJ, Blendy JA, Lucki I (2005) Strain-dependent antidepressant-like effects of citalopram in the mouse tail suspension test. Psychopharmacology 183:257\u2013264. doi: 10.1007\/s00213-005-0166-5","journal-title":"Psychopharmacology"},{"key":"3230_CR12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0149-7634(01)00022-7","volume":"25","author":"D Drai","year":"2001","unstructured":"Drai D, Golani I (2001) SEE: a tool for the visualization and analysis of rodent exploratory behavior. Neurosci Biobehav Rev 25:409\u2013426. doi: 10.1016\/S0149-7634(01)00022-7","journal-title":"Neurosci Biobehav Rev"},{"key":"3230_CR13","first-page":"1189","volume":"43","author":"SL Dubovsky","year":"1992","unstructured":"Dubovsky SL, Thomas M (1992) Psychotic depression: advances in conceptualization and treatment. Hosp Community Psychiatry 43:1189\u20131198","journal-title":"Hosp Community Psychiatry"},{"issue":"1","key":"3230_CR14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0091-3057(86)90266-2","volume":"25","author":"MA Geyer","year":"1986","unstructured":"Geyer MA, Russo PV, Masten VL (1986) Multivariate assessment of locomotor behavior: pharmacological and behavioral analyses. Pharmacol Biochem Behav 25(1):277\u2013288","journal-title":"Pharmacol Biochem Behav"},{"key":"3230_CR15","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1126\/science.286.5439.531","volume":"286","author":"TR Golub","year":"1999","unstructured":"Golub TR et al (1999) Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286:531\u2013537. doi: 10.1126\/science.286.5439.531","journal-title":"Science"},{"key":"3230_CR16","doi-asserted-by":"crossref","first-page":"9608","DOI":"10.1073\/pnas.1632587100","volume":"100","author":"EC Gunther","year":"2003","unstructured":"Gunther EC, Stone DJ, Gerwien RW, Bento P, Melvyn PH (2003) Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro. Proc Natl Acad Sci U S A 100:9608\u20139613. doi: 10.1073\/pnas.1632587100","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3230_CR17","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.neubiorev.2010.04.002","volume":"34","author":"BL Henry","year":"2010","unstructured":"Henry BL, Minassian A, Young J, Paulus MP, Geyer MA, Perry W (2010) Cross-species assessments of motor and exploratory behavior related to bipolar disorder. Neurosci Biobehav Rev 34:1296\u20131306. doi: 10.1016\/j.neubiorev.2010.04.002","journal-title":"Neurosci Biobehav Rev"},{"issue":"7","key":"3230_CR18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1601-183X.2005.00126.x","volume":"4","author":"N Kafkafi","year":"2005","unstructured":"Kafkafi N, Elmer GI (2005a) Texture of locomotor path: a replicable characterization of a complex behavioral phenotype. Genes Brain Behav 4(7):431\u2013443. doi: 10.1111\/j.1601-183X.2005.00126.x","journal-title":"Genes Brain Behav"},{"issue":"2","key":"3230_CR19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.pbb.2004.11.004","volume":"80","author":"N Kafkafi","year":"2005","unstructured":"Kafkafi N, Elmer GI (2005b) Activity density in the open field: a measure for differentiating the effect of psychostimulants. Pharmacol Biochem Behav 80(2):239\u2013249. doi: 10.1016\/j.pbb.2004.11.004","journal-title":"Pharmacol Biochem Behav"},{"issue":"12","key":"3230_CR20","doi-asserted-by":"crossref","first-page":"4619","DOI":"10.1073\/pnas.0409554102","volume":"102","author":"N Kafkafi","year":"2005","unstructured":"Kafkafi N, Benjamini Y, Sakov A, Elmer GI, Golani I (2005) Genotype\u2013environment interactions in mouse behavior: a way out of the problem. Proc Natl Acad Sci U S A 102(12):4619\u20134624. doi: 10.1073\/pnas.0409554102","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"3230_CR21","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1037\/0735-7044.122.4.777","volume":"122","author":"N Kafkafi","year":"2008","unstructured":"Kafkafi N, Yekutieli D, Yarowsky P, Elmer GI (2008) Data mining in a behavioral test detects early symptoms in a model of amyotrophic lateral sclerosis. Behav Neurosci 122(4):777\u2013787. doi: 10.1037\/0735-7044.122.4.777","journal-title":"Behav Neurosci"},{"issue":"3","key":"3230_CR22","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/npp.2008.103","volume":"34","author":"N Kafkafi","year":"2009","unstructured":"Kafkafi N, Yekutieli D, Elmer GI (2009) A data mining approach to in vivo classification of psychopharmacological drugs. Neuropsychopharmacology 34(3):607\u2013623. doi: 10.1038\/npp.2008.103","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"3230_CR23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bbr.2004.05.030","volume":"156","author":"JI Koenig","year":"2005","unstructured":"Koenig JI, Elmer GI, Shepard PD, Lee PR, Mayo C, Joy B, Hercher E, Brady DL (2005) Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia. Behav Brain Res 156(2):251\u2013261","journal-title":"Behav Brain Res"},{"key":"3230_CR24","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/nn.2647","volume":"13","author":"EJ Nestler","year":"2010","unstructured":"Nestler EJ, Hynan SE (2010) Animal models of neuropsychiatric disorders. Nat Neurosci 13:1161\u20131169. doi: 10.1038\/nn.2647","journal-title":"Nat Neurosci"},{"issue":"7","key":"3230_CR25","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrd2094","volume":"6","author":"MN Pangalos","year":"2007","unstructured":"Pangalos MN, Schechter LE, Hurko O (2007) Drug development for CNS disorders: strategies for balancing risk and reducing attrition. Nat Rev Drug Discov 6(7):521\u2013532. doi: 10.1038\/nrd2094","journal-title":"Nat Rev Drug Discov"},{"key":"3230_CR26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1517\/14728214.9.2.293","volume":"9","author":"CS Pataki","year":"2004","unstructured":"Pataki CS, Feinberg DT, McGough JJ (2004) New drugs for the treatment of attention-deficit\/hyperactivity disorder. Expert Opin Emerg Drugs 9:293\u2013302","journal-title":"Expert Opin Emerg Drugs"},{"key":"3230_CR27","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00213-004-2048-7","volume":"177","author":"B Petit-Demouliere","year":"2005","unstructured":"Petit-Demouliere B, Chenu F, Bourin M (2005) Forced swimming test in mice: a review of antidepressant activity. Psychopharmacology 177:245\u2013255. doi: 10.1007\/s00213-004-2048-7","journal-title":"Psychopharmacology"},{"key":"3230_CR28","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neuroscience.2011.03.026","volume":"182","author":"MN Quan","year":"2011","unstructured":"Quan MN, Zhang N, Wang YY, Zhang T, Yang Z (2011) Possible antidepressant effects and mechanisms of memantine in behaviors and synaptic plasticity of a depression rat model. Neuroscience 182:88\u201397","journal-title":"Neuroscience"},{"issue":"5963","key":"3230_CR29","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.1183090","volume":"327","author":"J Rihel","year":"2010","unstructured":"Rihel J et al (2010) Zebrafish behavioral profiling links drugs to biological targets and rest\/wake regulation. Science 327(5963):348\u2013351. doi: 10.1126\/science.1183090","journal-title":"Science"},{"key":"3230_CR30","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nrd3559","volume":"10","author":"DT Schopp","year":"2011","unstructured":"Schopp DT (2011) Where will new neuroscience therapies come from? Nat Rev Drug Discov 10:715\u2013716. doi: 10.1038\/nrd3559","journal-title":"Nat Rev Drug Discov"},{"key":"3230_CR31","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0304-3940(99)00627-8","volume":"273","author":"S Schreiber","year":"1999","unstructured":"Schreiber S, Backer MM, Pick CG (1999) The antinociceptive effect of venlafaxine in mice is mediated through opioid and adrenergic mechanisms. Neurosci Lett 273:85\u201388","journal-title":"Neurosci Lett"},{"key":"3230_CR32","volume-title":"Introduction to data mining. Classification: basic concepts, decision trees and model evaluation","author":"PN Tan","year":"2006","unstructured":"Tan PN, Steinbach M, Kumar V (2006) Introduction to data mining. Classification: basic concepts, decision trees and model evaluation. Addison\u2013Wesley, Boston"},{"key":"3230_CR33","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nn1225","volume":"7","author":"LH Tecott","year":"2004","unstructured":"Tecott LH, Nestler EJ (2004) Neurobehavioral assessment in the information age. Nat Neurosci 7:462\u2013466. doi: 10.1038\/nn1225","journal-title":"Nat Neurosci"},{"issue":"2","key":"3230_CR34","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000087097","volume":"52","author":"P Willner","year":"2005","unstructured":"Willner P (2005) Chronic mild stress (CMS) revisited: consistency and behavioural\u2013neurobiological concordance in the effects of CMS. Neuropsychobiology 52(2):90\u2013110. doi: 10.1159\/000087097","journal-title":"Neuropsychobiology"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-013-3230-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-013-3230-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-013-3230-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T16:36:29Z","timestamp":1558629389000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-013-3230-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,20]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["3230"],"URL":"https:\/\/doi.org\/10.1007\/s00213-013-3230-6","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,20]]}}}