{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:49:09Z","timestamp":1770821349760,"version":"3.50.1"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,10,26]],"date-time":"2013-10-26T00:00:00Z","timestamp":1382745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1007\/s00213-013-3304-5","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T06:51:26Z","timestamp":1382683886000},"page":"863-874","source":"Crossref","is-referenced-by-count":26,"title":["MDMA enhances hippocampal-dependent learning and memory under restrictive conditions, and modifies hippocampal spine density"],"prefix":"10.1007","volume":"231","author":[{"given":"S\u00f2nia","family":"Abad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Fole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"del Olmo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pubill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merc\u00e8","family":"Pall\u00e0s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e8lix","family":"Junyent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Camarasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Camins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Escubedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,10,26]]},"reference":[{"key":"3304_CR1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.biopsych.2005.09.006","volume":"59","author":"JA Able","year":"2006","unstructured":"Able JA, Gudelsky GA, Vorhees CV, Williams MT (2006) 3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory. Biol Psychiatry 59:1219\u20131226","journal-title":"Biol Psychiatry"},{"key":"3304_CR2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ijdevneu.2004.06.002","volume":"22","author":"SL Andersen","year":"2004","unstructured":"Andersen SL, Navalta CP (2004) Altering the course of neurodevelopment: a framework for understanding the enduring effects of psychotropic drugs. Int J Dev Neurosci 22:423\u2013440","journal-title":"Int J Dev Neurosci"},{"key":"3304_CR3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1369-1600.2010.00221.x","volume":"15","author":"F Angelucci","year":"2010","unstructured":"Angelucci F, Ricci V, Martinotti G, Palladino I, Spalletta G, Caltagirone C, Bria P (2010) Ecstasy (MDMA)-addicted subjects show increased serum levels of brain-derived neurotrophic factor, independently from a rise of drug-induced psychotic symptoms. Addict Biol 15:365\u2013367","journal-title":"Addict Biol"},{"key":"3304_CR4","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.neuropharm.2012.07.026","volume":"63","author":"JH Anneken","year":"2012","unstructured":"Anneken JH, Gudelsky GA (2012) MDMA produces a delayed and sustained increase in the extracellular concentration of glutamate in the rat hippocampus. Neuropharmacology 63:1022\u20131027","journal-title":"Neuropharmacology"},{"key":"3304_CR5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/neuro.01.1.1.010.2007","volume":"1","author":"JI Arellano","year":"2007","unstructured":"Arellano JI, Benavides-Piccione R, De Felipe J, Yuste R (2007) Ultrastructure of dendritic spines: correlation between synaptic and spine morphologies. Front Neurosci 1:131\u2013143","journal-title":"Front Neurosci"},{"key":"3304_CR6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.neulet.2009.12.031","volume":"469","author":"A Arias-Cavieres","year":"2010","unstructured":"Arias-Cavieres A, Rozas C, Reyes-Parada M, Barrera N, Pancetti F, Loyola S et al (2010) MDMA (\u201cecstasy\u201d) impairs learning in the Morris Water Maze and reduces hippocampal LTP in young rats. Neurosci Lett 469:375\u2013379","journal-title":"Neurosci Lett"},{"key":"3304_CR7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.neuroscience.2009.02.025","volume":"160","author":"KT Ball","year":"2009","unstructured":"Ball KT, Wellman CL, Fortenberry, Rebec GV (2009) Sensitizing regimens of (+\/\u2212)3,4-methylenedioxymethamphetamine (ecstasy) elicit enduring and differential structural alterations in the brain motive circuit of the rat. Neuroscience 160:264\u2013274","journal-title":"Neuroscience"},{"key":"3304_CR8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0091-3057(88)90155-4","volume":"29","author":"G Battaglia","year":"1988","unstructured":"Battaglia G, Yeh SY, De Souza EB (1988) MDMA-induced neurotoxicity: parameters of degeneration and recovery of brain serotonin neurons. Pharmacol Biochem Behav 29:269\u2013274","journal-title":"Pharmacol Biochem Behav"},{"key":"3304_CR9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/BF03033301","volume":"6","author":"RJ Beninger","year":"2004","unstructured":"Beninger RJ, Gerdjikov T (2004) The role of signaling molecules in reward-related incentive learning. Neurotox Res 6:91\u2013104","journal-title":"Neurotox Res"},{"key":"3304_CR10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/00207458909002151","volume":"48","author":"R Brandeis","year":"1989","unstructured":"Brandeis R, Brandys Y, Yehuda S (1989) The use of the Morris Water Maze in the study of memory and learning. Int J Neurosci 48:29\u201369","journal-title":"Int J Neurosci"},{"key":"3304_CR11","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.neubiorev.2011.04.013","volume":"35","author":"HC Brenhouse","year":"2011","unstructured":"Brenhouse HC, Andersen SL (2011) Developmental trajectories during adolescence in males and females: a cross-species understanding of underlying brain changes. Neurosci Biobehav Rev 35:1687\u20131703","journal-title":"Neurosci Biobehav Rev"},{"key":"3304_CR12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1101\/lm.1650110","volume":"17","author":"NJ Broadbent","year":"2009","unstructured":"Broadbent NJ, Gaskin S, Squire LR, Clark RE (2009) Object recognition memory and the rodent hippocampus. Learn Mem 17:5\u201311","journal-title":"Learn Mem"},{"key":"3304_CR13","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1523\/JNEUROSCI.21-09-03228.2001","volume":"21","author":"HW Broening","year":"2001","unstructured":"Broening HW, Morford LL, Inman-Wood SL, Fukumura M, Vorhees CV (2001) 3,4-Methylenedioxymethamphetamine (ecstasy)-induced learning and memory impairments depend on the age of exposure during early development. J Neurosci 21:3228\u20133235","journal-title":"J Neurosci"},{"key":"3304_CR14","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejphar.2008.05.014","volume":"589","author":"J Camarasa","year":"2008","unstructured":"Camarasa J, Marim\u00f3n JM, Rodrigo T, Escubedo E, Pubill D (2008) Memantine prevents the cognitive impairment induced by 3,4-methylenedioxymethamphetamine in rats. Eur J Pharmacol 589:132\u2013139","journal-title":"Eur J Pharmacol"},{"key":"3304_CR15","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.neuropharm.2006.05.032","volume":"51","author":"C Chipana","year":"2006","unstructured":"Chipana C, Camarasa J, Pubill D, Escubedo E (2006) Protection against MDMA-induced dopaminergic neurotoxicity in mice by methyllycaconitine: involvement of nicotinic receptors. Neuropharmacology 51:885\u2013895","journal-title":"Neuropharmacology"},{"key":"3304_CR16","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/syn.20166","volume":"57","author":"MA Cohen","year":"2005","unstructured":"Cohen MA, Skelton MR, Schaefer TL, Gudelsky GA, Vorhees CV, Williams MT (2005) Learning and memory after neonatal exposure to 3,4-methylenedioxymethamphetamine (ecstasy) in rats: interaction with exposure in adulthood. Synapse 57:148\u2013159","journal-title":"Synapse"},{"key":"3304_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.beproc.2005.09.007","volume":"71","author":"RA Colorado","year":"2006","unstructured":"Colorado RA, Shumake J, Conejo NM, Gonzalez-Pardo H, Gonzalez-Lima F (2006) Effects of maternal separation, early handling, and standard facility rearing on orienting and impulsive behavior of adolescent rat. Behav Process 71:1\u201358","journal-title":"Behav Process"},{"key":"3304_CR18","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","volume":"36","author":"R D\u2019Hooge","year":"2001","unstructured":"D\u2019Hooge R, De Deyn PP (2001) Applications of the Morris water maze in the study of learning and memory. Brain Res Rev 36:60\u201390","journal-title":"Brain Res Rev"},{"key":"3304_CR19","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.pbb.2010.05.005","volume":"9","author":"TL Doremus-Fitzwater","year":"2010","unstructured":"Doremus-Fitzwater TL, Spear LP (2010) Age-related differences in amphetamine sensitization: effects of prior drug or stress history on stimulant sensitization in juvenile and adult rats. Pharmacol Biochem Behav 9:198\u2013205","journal-title":"Pharmacol Biochem Behav"},{"key":"3304_CR20","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/nn1579","volume":"11","author":"BJ Everitt","year":"2005","unstructured":"Everitt BJ, Robbins TW (2005) Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 11:1481\u20131489","journal-title":"Nat Neurosci"},{"key":"3304_CR21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.nlm.2011.02.012","volume":"95","author":"A Fole","year":"2011","unstructured":"Fole A, Gonz\u00e1lez-Mart\u00edn C, Huarte C, Alguacil LF, Ambrosio E, Del Olmo N (2011) Effects of chronic cocaine administration on spatial learning and hippocampal spine density in two genetically different strains of rats. Neurobiol Learn Mem 95:491\u2013497","journal-title":"Neurobiol Learn Mem"},{"key":"3304_CR22","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.taap.2010.01.014","volume":"244","author":"S Garcia-Rat\u00e9s","year":"2010","unstructured":"Garcia-Rat\u00e9s S, Camarasa J, S\u00e1nchez-Garc\u00eda AI, Gand\u00eda L, Escubedo E, Pubill D (2010) The effects of 3,4-methylenedioxymethamphetamine (MDMA) on nicotinic receptors: intracellular calcium increase, calpain\/caspase 3 activation, and functional upregulation. Toxicol Appl Pharmacol 244:344\u2013353","journal-title":"Toxicol Appl Pharmacol"},{"key":"3304_CR23","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1124\/pr.55.3.3","volume":"55","author":"AR Green","year":"2003","unstructured":"Green AR, Mechan AO, Elliott JM, O\u2019Shea E, Colado MI (2003) The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, \u201cecstasy\u201d). Pharmacol Rev 55:463\u2013508","journal-title":"Pharmacol Rev"},{"key":"3304_CR24","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1002\/cne.23048","volume":"520","author":"AM Hemmerle","year":"2012","unstructured":"Hemmerle AM, Dickerson JW, Herring NR, Schaefer TL, Vorhees CV, Williams MT et al (2012) (\u00b1)3,4-Methylenedioxymethamphetamine (\u201cecstasy\u201d) treatment modulates expression of neurotrophins and their receptors in multiple regions of adult rat brain. J Comp Neurol 520:2459\u20132474","journal-title":"J Comp Neurol"},{"key":"3304_CR25","doi-asserted-by":"crossref","first-page":"19571","DOI":"10.1073\/pnas.0709311104","volume":"104","author":"J Hongpaisan","year":"2007","unstructured":"Hongpaisan J, Alkon DL (2007) A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC. Proc Natl Acad Sci U S A 104:19571\u201319576","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3304_CR26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.nbd.2013.03.012","volume":"55","author":"J Hongpaisan","year":"2013","unstructured":"Hongpaisan J, Xu C, Sen A, Nelson TJ, Alkon DL (2013) PKC activation during training restores mushroom spine synapses and memory in the aged rat. Neurobiol Dis 55:44\u201362","journal-title":"Neurobiol Dis"},{"key":"3304_CR27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1177\/0269881109102787","volume":"23","author":"P\u00d8 Johansen","year":"2009","unstructured":"Johansen P\u00d8, Krebs TS (2009) How could MDMA (ecstasy) help anxiety disorders? A neurobiological rationale. J Psychopharmacol 23:389\u2013391","journal-title":"J Psychopharmacol"},{"key":"3304_CR28","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrn1517","volume":"5","author":"E Kim","year":"2004","unstructured":"Kim E, Sheng M (2004) PDZ domain proteins of synapses. Nat Rev Neurosci 5:771\u2013781","journal-title":"Nat Rev Neurosci"},{"key":"3304_CR29","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/13178","volume":"2","author":"SA Kirov","year":"1999","unstructured":"Kirov SA, Harris KM (1999) Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated. Nat Neurosci 2:878\u2013883","journal-title":"Nat Neurosci"},{"key":"3304_CR30","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/BF02244610","volume":"3","author":"MG Kolta","year":"1990","unstructured":"Kolta MG, Scalzo FM, Ali SF, Holson RR (1990) Ontogeny of the enhanced behavioral response to amphetamine in amphetamine-pretreated rat. Psychopharmacology (Berlin) 3:377\u2013382","journal-title":"Psychopharmacology (Berlin)"},{"key":"3304_CR31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0893-133X(97)00026-2","volume":"17","author":"HK Kramer","year":"1997","unstructured":"Kramer HK, Poblete JC, Azmitia EC (1997) Activation of protein kinase C (PKC) by 3,4-methylenedioxymethamphetamine (MDMA) occurs through the stimulation of serotonin receptors and transporter. Neuropsychopharmacology 17:117\u2013129","journal-title":"Neuropsychopharmacology"},{"key":"3304_CR32","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1177\/0269881112472566","volume":"2","author":"F Leri","year":"2013","unstructured":"Leri F, Nahas E, Henderson K, Limebeer CL, Parker LA, White NM (2013) Effects of post-training heroin and d-amphetamine on consolidation of win-stay learning and fear conditioning. J Psychopharmacol 2:292\u2013301","journal-title":"J Psychopharmacol"},{"key":"3304_CR33","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1523\/JNEUROSCI.23-02-00659.2003","volume":"23","author":"B Leuner","year":"2003","unstructured":"Leuner B, Falduto J, Shors TJ (2003) Associative memory formation increases the observation of dendritic spines in the hippocampus. J Neurosci 23:659\u2013665","journal-title":"J Neurosci"},{"key":"3304_CR34","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0031-9384(97)00442-3","volume":"63","author":"BA McMillen","year":"1998","unstructured":"McMillen BA, Means LW, Matthews JN (1998) Comparison of the alcohol-preferring P rat to the Wistar rat in behavioral tests of impulsivity and anxiety. Physiol Behav 63:371\u2013375","journal-title":"Physiol Behav"},{"key":"3304_CR35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s002130100900","volume":"159","author":"AO Mechan","year":"2002","unstructured":"Mechan AO, Moran PM, Elliott M, Young AJ, Joseph MH, Green R (2002) A study of the effect of a single neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; \u201cecstasy\u201d) on the subsequent long-term behavior of rats in the plus maze and open field. Psychopharmacology (Berlin) 159:167\u2013175","journal-title":"Psychopharmacology (Berlin)"},{"key":"3304_CR36","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1177\/0269881110378371","volume":"25","author":"MC Mithoefer","year":"2011","unstructured":"Mithoefer MC, Wagner MT, Mithoefer AT, Jerome L, Doblin R (2011) The safety and efficacy of \u00b13,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study. J Psychopharmacol 25:439\u2013452","journal-title":"J Psychopharmacol"},{"key":"3304_CR37","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1177\/0269881112456611","volume":"27","author":"MC Mithoefer","year":"2013","unstructured":"Mithoefer MC, Wagner MT, Mithoefer AT, Jerome L, Martin SF, Yazar-Klosinski B et al (2013) Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study. J Psychopharmacol 27:28\u201339","journal-title":"J Psychopharmacol"},{"key":"3304_CR38","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ijdevneu.2012.01.006","volume":"30","author":"MD Moenk","year":"2012","unstructured":"Moenk MD, Matuszewich L (2012) Juvenile but not adult methamphetamine exposure improves performance in the Morris Water Maze in male rats. Int J Dev Neurosci 30:325\u2013331","journal-title":"Int J Dev Neurosci"},{"key":"3304_CR39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.euroneuro.2010.07.007","volume":"21","author":"R Morini","year":"2011","unstructured":"Morini R, Mlinar B, Baccini G, Corradetti R (2011) Enhanced hippocampal long-term potentiation following repeated MDMA treatment in Dark-Agouti rats. Eur Neuropsychopharmacol 21:80\u201391","journal-title":"Eur Neuropsychopharmacol"},{"key":"3304_CR40","doi-asserted-by":"crossref","first-page":"12673","DOI":"10.1073\/pnas.91.26.12673","volume":"91","author":"MB Moser","year":"1994","unstructured":"Moser MB, Trommald M, Andersen P (1994) An increase in dendritic spine density on hippocampal CA1 pyramidal cells following spatial learning in adult rats suggests the formation of new synapses. Proc Natl Acad Sci U S A 91:12673\u201312675","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3304_CR41","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s00213-005-0271-5","volume":"184","author":"SG Nair","year":"2006","unstructured":"Nair SG, Gudelsky GA (2006) 3,4-Methylenedioxymethamphetamine enhances the release of acetylcholine in the prefrontal cortex and dorsal hippocampus of the rat. Psychopharmacology (Berlin) 184:182\u2013189","journal-title":"Psychopharmacology (Berlin)"},{"key":"3304_CR42","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0278-5846(00)00179-2","volume":"25","author":"ED O\u2019Loinsigh","year":"2001","unstructured":"O\u2019Loinsigh ED, Boland G, Kelly JP, O\u2019Boyle KM (2001) Behavioral, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat. Prog Neuropsychopharmacol Biol Psychiatry 25:621\u2013638","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3304_CR43","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-2999(78)90414-4","volume":"51","author":"RD Porsolt","year":"1978","unstructured":"Porsolt RD, Bertin A, Jalfre M (1978) \u201cBehavioral despair\u201d in rats and mice: strain differences and the effects of imipramine. Eur J Pharmacol 51:291\u2013294","journal-title":"Eur J Pharmacol"},{"key":"3304_CR44","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1258\/ebm.2012.012020","volume":"237","author":"D Preissmann","year":"2012","unstructured":"Preissmann D, Leuba G, Savary C, Vernay A, Kraftsik R, Riederer IM et al (2012) Increased postsynaptic density protein-95 expression in the frontal cortex of aged cognitively impaired rats. Exp Biol Med 237:1331\u20131340","journal-title":"Exp Biol Med"},{"key":"3304_CR45","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1007\/s00210-003-0747-y","volume":"367","author":"D Pubill","year":"2003","unstructured":"Pubill D, Canudas AM, Pallas M, Camins A, Camarasa J, Escubedo E (2003) Different glial response to methamphetamine- and methylenedioxymethamphetamine-induced neurotoxicity. Naunyn Schmiedebergs Arch Pharmacol 367:490\u2013499","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"3304_CR46","doi-asserted-by":"crossref","first-page":"8491","DOI":"10.1523\/JNEUROSCI.17-21-08491.1997","volume":"17","author":"TE Robinson","year":"1997","unstructured":"Robinson TE, Kolb B (1997) Persistent structural modifications in nucleus accumbens and prefrontal cortex neurons produced by previous experience with amphetamine. J Neurosci 17:8491\u20138497","journal-title":"J Neurosci"},{"key":"3304_CR47","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1046\/j.1460-9568.1999.00576.x","volume":"1","author":"TE Robinson","year":"1999","unstructured":"Robinson TE, Kolb B (1999) Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine. Eur J Neurosci 1:1598\u20131604","journal-title":"Eur J Neurosci"},{"key":"3304_CR48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuropharm.2004.06.025","volume":"47","author":"TE Robinson","year":"2004","unstructured":"Robinson TE, Kolb B (2004) Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology 47:33\u201346","journal-title":"Neuropharmacology"},{"key":"3304_CR49","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00213-010-1921-9","volume":"213","author":"R Rodsiri","year":"2011","unstructured":"Rodsiri R, Spicer C, Green AR, Marsden CA, Fone KC (2011) Acute concomitant effects of MDMA binge dosing on extracellular 5-HT, locomotion and body temperature and the long-term effect on novel object discrimination in rats. Psychopharmacology (Berlin) 213:365\u2013376","journal-title":"Psychopharmacology (Berlin)"},{"key":"3304_CR50","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1177\/026988110401800312","volume":"18","author":"V Sanchez","year":"2004","unstructured":"Sanchez V, O\u2019Shea E, Saadat KS, Elliott JM, Colado MI, Green AR (2004) Effect of repeated (\u2018binge\u2019) dosing of MDMA to rats housed at normal and high temperature on neurotoxic damage to cerebral 5-HT and dopamine neurons. J Psychopharmacol 18:412\u2013416","journal-title":"J Psychopharmacol"},{"key":"3304_CR51","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.brainres.2006.05.023","volume":"1101","author":"F Serres","year":"2006","unstructured":"Serres F, Carney SL (2006) Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor. Brain Res 1101:36\u201342","journal-title":"Brain Res"},{"key":"3304_CR52","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.nlm.2006.04.005","volume":"86","author":"NW Simon","year":"2006","unstructured":"Simon NW, Setlow B (2006) Post-training amphetamine administration enhances memory consolidation in appetitive Pavlovian conditioning: implications for drug addiction. Neurobiol Learn Mem 86:305\u2013310","journal-title":"Neurobiol Learn Mem"},{"key":"3304_CR53","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.neuropharm.2008.07.006","volume":"55","author":"MR Skelton","year":"2008","unstructured":"Skelton MR, Able JA, Grace CE, Herring NR, Schaefer TL, Gudelsky GA et al (2008) (+\/)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks. Neuropharmacology 55:1121\u20131130","journal-title":"Neuropharmacology"},{"key":"3304_CR54","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1017\/S1461145711000952","volume":"15","author":"MR Skelton","year":"2012","unstructured":"Skelton MR, Graham DL, Schaefer TL, Grace CE, Braun AA, Burns LN et al (2012) Distinct periods of developmental sensitivity to the effects of 3,4-(\u00b1)-methylenedioxymethamphetamine (MDMA) on behaviour and monoamines in rats. Int J Neuropsychopharmacol 15:811\u2013824","journal-title":"Int J Neuropsychopharmacol"},{"key":"3304_CR55","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nprot.2012.044","volume":"7","author":"DA Slattery","year":"2012","unstructured":"Slattery DA, Cryan JF (2012) Using the rat forced swim test to assess antidepressant-like activity in rodents. Nat Protoc 7:1009\u20131014","journal-title":"Nat Protoc"},{"key":"3304_CR56","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0031-9384(03)00092-1","volume":"79","author":"JE Sprague","year":"2003","unstructured":"Sprague JE, Preston AS, Leifheit M, Woodside B (2003) Hippocampal serotonergic damage induced by MDMA (ecstasy): effects on spatial learning. Physiol Behav 79:281\u2013287","journal-title":"Physiol Behav"},{"key":"3304_CR57","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1126\/science.1152864","volume":"319","author":"J Tanaka","year":"2008","unstructured":"Tanaka J, Horiike Y, Matsuzaki M, Miyazaki T, Ellis-Davies GC, Kasai H (2008) Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines. Science 319:1683\u20131687","journal-title":"Science"},{"key":"3304_CR58","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.physbeh.2008.12.013","volume":"96","author":"VB Thompson","year":"2009","unstructured":"Thompson VB, Heiman J, Chambers JB, Benoit SC, Buesing WR, Norman MK et al (2009) Long-term behavioral consequences of prenatal MDMA exposure. Physiol Behav 96:593\u2013601","journal-title":"Physiol Behav"},{"key":"3304_CR59","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0149-7634(03)00018-6","volume":"27","author":"E Tirelli","year":"2003","unstructured":"Tirelli E, Laviola G, Adriani W (2003) Ontogenesis of behavioral sensitization and conditioned place preference induced by psychostimulants in laboratory rodents. Neurosci Biobehav Rev 27:163\u2013178","journal-title":"Neurosci Biobehav Rev"},{"key":"3304_CR60","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000207499","volume":"31","author":"CV Vorhees","year":"2009","unstructured":"Vorhees CV, Schaefer TL, Skelton MR, Grace CE, Herring NR, Williams MT (2009) (+\/\u2212)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the Morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twenty. Dev Neurosci 31:107\u2013120","journal-title":"Dev Neurosci"},{"key":"3304_CR61","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/syn.20854","volume":"65","author":"CV Vorhees","year":"2011","unstructured":"Vorhees CV, He E, Skelton MR, Graham DL, Schaefer TL, Grace CE et al (2011) Comparison of (+)-methamphetamine, \u00b1\u2009\u2212\u2009methylenedioxymethamphetamine, (+)-amphetamine and\u2009\u00b1\u2009\u2212fenfluramine in rats on egocentric learning in the Cincinnati water maze. Synapse 65:368\u2013378","journal-title":"Synapse"},{"key":"3304_CR62","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.nlm.2009.02.001","volume":"92","author":"KA Wiig","year":"2009","unstructured":"Wiig KA, Whitlock JR, Epstein MH, Carpenter RL, Bear MF (2009) The levo enantiomer of amphetamine increases memory consolidation and gene expression in the hippocampus without producing locomotor stimulation. Neurobiol Learn Mem 92:106\u2013113","journal-title":"Neurobiol Learn Mem"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-013-3304-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-013-3304-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-013-3304-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T05:08:26Z","timestamp":1564549706000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-013-3304-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,26]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["3304"],"URL":"https:\/\/doi.org\/10.1007\/s00213-013-3304-5","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,26]]}}}