{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:46:16Z","timestamp":1787957176969,"version":"build-2784847793"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"17","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s00213-014-3590-6","type":"journal-article","created":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T00:42:33Z","timestamp":1398818553000},"page":"3425-3436","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Adrenal steroid hormones and ethanol self-administration in male rhesus macaques"],"prefix":"10.1007","volume":"231","author":[{"given":"Christa M.","family":"Helms","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,5,1]]},"reference":[{"key":"3590_CR1","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0006-3223(96)00381-2","volume":"40","author":"B Adinoff","year":"1996","unstructured":"Adinoff B, Kiser JMC, Martin PR, Linnoila M (1996) Response of dehydroepiandrosterone to corticotropin-releasing hormone stimulation in alcohol-dependent subjects. Biol Psychiatry 40:1305\u20131307","journal-title":"Biol Psychiatry"},{"key":"3590_CR2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/01.ALC.0000158940.05529.0A","volume":"29","author":"B Adinoff","year":"2005","unstructured":"Adinoff B, Krebaum SR, Chandler PA, Ye W, Brown MB, Williams MJ (2005) Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent men, part 1: adrenocortical and pituitary glucocorticoid responsiveness. Alcohol Clin Exp Res 29:517\u2013527","journal-title":"Alcohol Clin Exp Res"},{"key":"3590_CR3","doi-asserted-by":"crossref","unstructured":"Ator NA, Grant KA, Purdy RH, Paul SM, Griffiths RR (1993) Drug discrimination analysis of endogenous neuroactive steroids in rats. Eur J Pharmacol 241:237\u2013243","DOI":"10.1016\/0014-2999(93)90208-Y"},{"key":"3590_CR4","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1210\/jcem.81.9.8784058","volume":"81","author":"E-E Baulieu","year":"1996","unstructured":"Baulieu E-E (1996) Dehydroepiandrosterone (DHEA): a fountain of youth? J Clin Endocrinol Metab 81:3147\u20133151","journal-title":"J Clin Endocrinol Metab"},{"key":"3590_CR5","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1210\/jcem-71-3-712","volume":"71","author":"JD Berman","year":"1990","unstructured":"Berman JD, Cook DM, Buchman M, Keith LD (1990) Diminished adrenocorticotropin response to insulin-induced hypoglycemia in nondepressed, actively drinking male alcoholics. J Clin Endocrinol Metab 71:712\u2013717","journal-title":"J Clin Endocrinol Metab"},{"key":"3590_CR6","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00213-011-2533-8","volume":"220","author":"J Besheer","year":"2012","unstructured":"Besheer J, Fisher KR, Grondin JJM, Cannady R, Hodge CW (2012) The effects of repeated corticosterone exposure on the interoceptive effects of alcohol in rats. Psychopharmacology 220:809\u2013822","journal-title":"Psychopharmacology"},{"key":"3590_CR7","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neuropharm.2013.04.036","volume":"72","author":"J Besheer","year":"2013","unstructured":"Besheer J, Fisher KR, Lindsay TG, Cannady R (2013) Transient increase in alcohol self-administration following a period of chronic exposure to corticosterone. Neuropharmacology 72:139\u2013147","journal-title":"Neuropharmacology"},{"key":"3590_CR8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0163-7258(90)90077-F","volume":"48","author":"G Biggio","year":"1990","unstructured":"Biggio G, Concas A, Corda MG, Girogi O, Sanna E, Serra M (1990) GABAergic and dopaminergic transmission in the rat cerebral cortex: effect of stress, anxiolytic and anxiogenic drugs. Pharmacol Ther 48:121\u2013142","journal-title":"Pharmacol Ther"},{"key":"3590_CR9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0006-8993(91)90761-J","volume":"561","author":"D Bitran","year":"1991","unstructured":"Bitran D, Hilvers RJ, Kellogg CK (1991) Anxiolytic effects of 3\u03b1-hydroxy-5\u03b1[\u03b2]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor. Brain Res 561:157\u2013161","journal-title":"Brain Res"},{"key":"3590_CR10","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/j.1471-4159.2009.06509.x","volume":"112","author":"KN Boyd","year":"2010","unstructured":"Boyd KN, Kumar S, O\u2019Buckley TK, Porcu P, Morrow AL (2010) Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis. J Neurochem 112:784\u2013796","journal-title":"J Neurochem"},{"key":"3590_CR11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00213-004-1986-4","volume":"178","author":"JH Broadbear","year":"2005","unstructured":"Broadbear JH, Winger G, Woods JH (2005) Self-administration of methohexital, midazolam and ethanol: effects on the pituitary-adrenal axis in rhesus monkeys. Psychopharmacology 178:83\u201391","journal-title":"Psychopharmacology"},{"key":"3590_CR12","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1172\/JCI106937","volume":"51","author":"RD Brown","year":"1972","unstructured":"Brown RD, Strott CA, Liddle GW (1972) Site of stimulation of aldosterone biosynthesis by angiotensin and potassium. J Clin Investig 51:1413\u20131418","journal-title":"J Clin Investig"},{"key":"3590_CR13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnint.2013.00102","volume":"7","author":"TR Butler","year":"2014","unstructured":"Butler TR, Ariwodola OJ, Weiner JL (2014) The impact of social isolation on HPA axis function, anxiety-like behaviors, and ethanol drinking. Front Integr Neurosci 7:1\u201311","journal-title":"Front Integr Neurosci"},{"key":"3590_CR14","doi-asserted-by":"crossref","first-page":"13284","DOI":"10.1073\/pnas.95.22.13284","volume":"95","author":"A Concas","year":"1998","unstructured":"Concas A, Mostallino MC, Porcu P, Follesa P, Barbaccia ML, Trabucchi M, Purdy RH, Grisenti P, Biggio G (1998) Role of brain allopregnanolone in the plasticity of gamma-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery. Proc Natl Acad Sci U S A 95:13284\u201313289","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3590_CR15","doi-asserted-by":"crossref","unstructured":"Cuzon Carlson VC, Seabold GK, Helms CM, Garg N, Odagiri M, Rau AR, Daunais J, Alvarez VA, Lovinger DM, Grant KA (2011) Synaptic and morphological neuroadaptations in the putamen associated with long-term, relapsing alcohol drinking in primates. Neuropsychopharmacology 36:2513\u20132528","DOI":"10.1038\/npp.2011.140"},{"key":"3590_CR16","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1365-2826.2008.01800.x","volume":"21","author":"PW Czoty","year":"2009","unstructured":"Czoty PW, Gould RW, Nader MA (2009) Relationship between social rank and cortisol and testosterone concentrations in male cynomolgus monkeys (Macaca fascicularis). J Neuroendocrinol 21:68\u201376","journal-title":"J Neuroendocrinol"},{"key":"3590_CR17","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.psyneuen.2007.01.004","volume":"32","author":"X Dai","year":"2007","unstructured":"Dai X, Thavundayil J, Santella S, Gianoulakis C (2007) Response of the HPA-axis to alcohol and stress as a function of alcohol dependence and family history of alcoholism. Psychoneuroendocrinology 32:293\u2013305","journal-title":"Psychoneuroendocrinology"},{"key":"3590_CR18","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/BF02247439","volume":"124","author":"KA Grant","year":"1996","unstructured":"Grant KA, Azarov A, Bowen CA, Mirkis S, Purdy RH (1996) Ethanol-like discriminative stimulus effects of the neurosteroid 3\u03b1-hydroxy-5\u03b1-pregnan-20-one in female Macaca fascicularis monkeys. Psychopharmacology 124:340\u2013346","journal-title":"Psychopharmacology"},{"key":"3590_CR19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s002130050211","volume":"130","author":"KA Grant","year":"1997","unstructured":"Grant KA, Azarov A, Shively CA, Purdy RH (1997) Discriminative stimulus effects of ethanol and 3\u03b1-hydroxy-5\u03b1-pregnan-20-one in relation to menstrual cycle phase in cynomolgus monkeys (Macaca fascicularis). Psychopharmacology 130:59\u201368","journal-title":"Psychopharmacology"},{"key":"3590_CR20","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1124\/jpet.108.137315","volume":"326","author":"KA Grant","year":"2008","unstructured":"Grant KA, Helms CM, Rogers LSM, Purdy RH (2008a) Neuroactive steroid stereospecificity of ethanol-like discriminative stimulus effects in monkeys. J Pharmacol Exp Ther 326:354\u2013361","journal-title":"J Pharmacol Exp Ther"},{"key":"3590_CR21","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1111\/j.1530-0277.2008.00765.x","volume":"32","author":"KA Grant","year":"2008","unstructured":"Grant KA, Leng X, Green HL, Szeliga KT, Rogers LSM, Gonzales SW (2008b) Drinking typography established by scheduled induction predicts chronic heavy drinking in a monkey model of ethanol self-administration. Alcohol Clin Exp Res 32:1824\u20131838","journal-title":"Alcohol Clin Exp Res"},{"key":"3590_CR22","first-page":"407","volume-title":"Neurobiology of alcohol dependence","author":"KA Grant","year":"2014","unstructured":"Grant KA, Ferguson B, Helms CM, McClintick M (2014) Drinking to dependence risk factors in nonhuman primates. In: Changhai C, Noronha A, Harris A, Crabbe J (eds) Neurobiology of alcohol dependence. Elsevier, Oxford, pp 407\u2013424"},{"key":"3590_CR23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/978-1-4615-4871-3_41","volume":"449","author":"E Grazzini","year":"1998","unstructured":"Grazzini E, Boccara G, Joubert D, Trueba M, Durroux T, Guillon G, Gallo-Payet N, Chouinard L, Payet MD, Serradeil Le Gal C (1998) Vasopressin regulates adrenal functions by acting through different vasopressin receptor subtypes. Adv Exp Med Biol 449:325\u2013334","journal-title":"Adv Exp Med Biol"},{"key":"3590_CR24","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0026-0495(85)90090-3","volume":"34","author":"GT Griffing","year":"1985","unstructured":"Griffing GT, Allen J, Pratt H, Melby JC (1985) Discordance of plasma DHEA-S, DHEA, and cortisol responses with various ACTH regimens. Metabolism 34:631\u2013636","journal-title":"Metabolism"},{"key":"3590_CR25","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00213-005-0124-2","volume":"186","author":"C Grillon","year":"2006","unstructured":"Grillon C, Pine DS, Baas JMP, Lawley M, Ellis V, Charney DS (2006) Cortisol and DHEA-S are associated with startle potentiation during aversive conditioning in humans. Psychopharmacology 186:434\u2013441","journal-title":"Psychopharmacology"},{"key":"3590_CR26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-1781(99)00099-2","volume":"89","author":"A Heinz","year":"1999","unstructured":"Heinz A, Weingartner H, George D, Hommer D, Wolkowitz OM, Linnoila M (1999) Severity of depression in abstinent alcoholics is associated with monoamine metabolites and dehydroepiandrosterone-sulfate concentrations. Psychiatry Res 89:97\u2013106","journal-title":"Psychiatry Res"},{"key":"3590_CR28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00213-012-2707-z","volume":"224","author":"CM Helms","year":"2012","unstructured":"Helms CM, McClintick M, Grant KA (2012a) Social rank, chronic ethanol self-administration and hypothalamic-pituitary-adrenal axis response in monkeys. Psychopharmacology 224:133\u2013143","journal-title":"Psychopharmacology"},{"key":"3590_CR29","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/j.1530-0277.2011.01685.x","volume":"36","author":"CM Helms","year":"2012","unstructured":"Helms CM, Messaoudi I, Freeman WM, Vrana KE, Grant KA (2012b) A longitudinal analysis of circulating stress-related proteins and chronic ethanol self-administration in cynomolgus macaques. Alcohol Clin Exp Res 36:995\u20131003","journal-title":"Alcohol Clin Exp Res"},{"key":"3590_CR30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2012.00010","volume":"3","author":"CM Helms","year":"2012","unstructured":"Helms CM, Rossi DJ, Grant KA (2012c) Neurosteroid influences on sensitivity to ethanol. Front Endocrinol 3:1\u201319","journal-title":"Front Endocrinol"},{"key":"3590_CR27","doi-asserted-by":"crossref","unstructured":"Helms CM, Gonzales S, Green HL, Szeliga KT, Rogers LSM, Grant KA (2013) Diurnal pituitary-adrenal activity during schedule-induced polydipsia of water and ethanol in cynomolgus monkeys (Macaca fascicularis). Psychopharmacology 228:541\u2013549","DOI":"10.1007\/s00213-013-3052-6"},{"key":"3590_CR31","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1007\/s00213-013-3417-x","volume":"231","author":"CM Helms","year":"2014","unstructured":"Helms CM, Shaw J, Rau A, Stull C, Gonzales SW, Grant KA (2014) The effects of age at the onset of drinking to intoxication and chronic ethanol self-administration in male rhesus macaques. Psychopharmacology 231:1853\u20131861","journal-title":"Psychopharmacology"},{"key":"3590_CR32","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1177\/0269881109106955","volume":"24","author":"N Hlavacova","year":"2010","unstructured":"Hlavacova N, Bakos J, Jezova D (2010) Eplerenone, a selective mineralocorticoid receptor blocker, exerts anxiolytic effects accompanied by changes in stress hormone release. J Psychopharmacol 24:779\u2013786","journal-title":"J Psychopharmacol"},{"key":"3590_CR33","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2265.1995.tb02033.x","volume":"43","author":"WJ Inder","year":"1995","unstructured":"Inder WJ, Joyce PR, Ellis MJ, Evans MJ, Livesey JH, Donald RA (1995) The effects of alcoholism on the hypothalamic-pituitary-adrenal axis: interaction with endogenous opioid peptides. Clin Endocrinol 43:283\u2013290","journal-title":"Clin Endocrinol"},{"key":"3590_CR34","first-page":"1461","volume":"85","author":"KS Kanik","year":"2000","unstructured":"Kanik KS, Chrousos GP, Schumacher HR, Crane ML, Yarboro CH, Wilder RL (2000) Adrenocorticotropin, glucocorticoid, and androgen secretion in patients with new onset synovitis\/rheumatoid arthritis: relations with indices of inflammation. J Clin Endocrinol Metab 85:1461\u20131466","journal-title":"J Clin Endocrinol Metab"},{"key":"3590_CR35","doi-asserted-by":"crossref","unstructured":"Klok MD, Alt SR Irurzun Lafitte AJM, Turner JD, Lakke EAJF, Huitinga I, Muller CP, Zitman FG, de Kloet ER, DeRijk RH (2011) Decreased expression of mineralocorticoid receptor mRNA and its splice variants in postmortem brain regions of patients with major depressive disorder. J Psychiatric Res 45:871\u2013878","DOI":"10.1016\/j.jpsychires.2010.12.002"},{"key":"3590_CR36","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/npp.2013.259","volume":"39","author":"CD Kroenke","year":"2014","unstructured":"Kroenke CD, Rohlfing T, Park B, Sullivan EV, Pfefferbaum A, Grant KA (2014) Monkeys that voluntarily and chronically drink alcohol damage their brains: a longitudinal MRI study. Neuropsychopharmacology 39:823\u2013830","journal-title":"Neuropsychopharmacology"},{"key":"3590_CR37","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/j.1369-1600.2011.00344.x","volume":"16","author":"J Li","year":"2011","unstructured":"Li J, Bian W, Dave V, Ye J-H (2011) Blockade of GABAA receptors in the paraventricular nucleus of the hypothalamus attenuates voluntary ethanol intake and activates the hypothalamic-pituitary-adrenocortical axis. Addict Biol 16:600\u2013614","journal-title":"Addict Biol"},{"key":"3590_CR38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.yfrne.2008.11.002","volume":"30","author":"N Maninger","year":"2009","unstructured":"Maninger N, Wolkowitz OM, Reus VI, Epel ES, Mellon SH (2009) Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS). Front Neuroendocrinol 30:65\u201391","journal-title":"Front Neuroendocrinol"},{"key":"3590_CR39","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1530-0277.2008.00830.x","volume":"33","author":"BA McCool","year":"2009","unstructured":"McCool BA, Chappell AM (2009) Early social isolation in male Long-Evans rats alters both appetitive and consummatory behaviors expressed during operant ethanol self-administration. Alcohol Clin Exp Res 33:273\u2013282","journal-title":"Alcohol Clin Exp Res"},{"key":"3590_CR40","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/00006842-196607000-00037","volume":"28","author":"JH Mendelson","year":"1966","unstructured":"Mendelson JH, Stein S (1966) Serum cortisol levels in alcoholic and nonalcoholic subjects during experimentally induced ethanol intoxication. Psychosom Med 28:616\u2013626","journal-title":"Psychosom Med"},{"key":"3590_CR41","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0091-3057(81)90047-2","volume":"15","author":"MM Nieminen","year":"1981","unstructured":"Nieminen MM, Fyhrquist F, Linkola J, Tikkanen I, Tontti K (1981) Renin-aldosterone axis in ethanol intoxication. Pharmacol Biochem Behav 15:879\u2013882","journal-title":"Pharmacol Biochem Behav"},{"key":"3590_CR42","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1172\/JCI119261","volume":"99","author":"VK Patchev","year":"1997","unstructured":"Patchev VK, Montkowski A, Rouskova D, Koranyi L, Holsboer F, Almeida OFX (1997) Neonatal treatment of rats with the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) abolishes the behavioral and neuroendocrine consequences of adverse early life events. J Clin Investig 99:962\u2013966","journal-title":"J Clin Investig"},{"key":"3590_CR43","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00213-005-0231-0","volume":"186","author":"A Pierucci-Lagha","year":"2006","unstructured":"Pierucci-Lagha A, Covault J, Feinn R, Khisti RT, Morrow AL, Marx CE, Shampine AL, Marx CE, Shampine LJ, Kranzler JR (2006) Subjective effects and changes in steroid hormone concentrations in humans following acute consumption of ethanol. Psychopharmacology 186:451\u2013461","journal-title":"Psychopharmacology"},{"key":"3590_CR44","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.euroneuro.2010.07.006","volume":"21","author":"MG Pisu","year":"2011","unstructured":"Pisu MG, Mostallino MC, Dore R, Maciocco E, Secci PP, Serra M (2011) Effects of voluntary ethanol consumption on emotional state and stress responsiveness in socially isolated rats. Eur Neuropsychopharmacol 21:414\u2013425","journal-title":"Eur Neuropsychopharmacol"},{"key":"3590_CR45","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00213-005-0132-2","volume":"186","author":"P Porcu","year":"2006","unstructured":"Porcu P, Grant KA, Green HL, Rogers LSM, Morrow AL (2006) Hypothalamic-pituitary-adrenal axis and ethanol modulation of deoxycorticosterone levels in cynomolgus monkeys. Psychopharmacology 186:293\u2013301","journal-title":"Psychopharmacology"},{"key":"3590_CR46","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.psyneuen.2007.11.003","volume":"33","author":"P Porcu","year":"2008","unstructured":"Porcu P, O\u2019Buckley TK, Morrow AL, Adinoff B (2008) Differential hypothalamic-pituitary-adrenal activation of the neuroactive steroids pregnenolone sulfate and deoxycorticosterone in healthy controls and alcohol-dependent subjects. Psychoneuroendocrinology 33:214\u2013226","journal-title":"Psychoneuroendocrinology"},{"key":"3590_CR47","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1530-0277.2009.01123.x","volume":"34","author":"P Porcu","year":"2010","unstructured":"Porcu P, O\u2019Buckley TK, Alward SE, Song SC, Grant KA, de Wit H, Morrow AL (2010) Differential effects of ethanol on serum GABAergic 3\u03b1,5\u03b1\/3\u03b1,5\u03b2 neuroactive steroids in mice, rats, cynomolgus monkeys and humans. Alcohol Clin Exp Res 34:432\u2013442","journal-title":"Alcohol Clin Exp Res"},{"key":"3590_CR48","doi-asserted-by":"crossref","first-page":"e18405","DOI":"10.1371\/journal.pone.0018405","volume":"6","author":"P Porcu","year":"2011","unstructured":"Porcu P, O'Buckley TK, Song SC, Harenza JL, Lu L, Wang X, Williams RW, Miles MF, Morrow A (2011) Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation. PLoS ONE 6:e18405","journal-title":"PLoS ONE"},{"key":"3590_CR49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/neuro.08.040.2009","volume":"3","author":"AD Radant","year":"2009","unstructured":"Radant AD, Dobie DJ, Peskind ER, Murburg MM, Petrie EC, Kanter ED, Raskind MA, Wilkinson CW (2009) Adrenocortical responsiveness to infusions of physiological doses of ACTH is not altered in posttraumatic stress disorder. Front Behav Neurosci 3:1\u20138","journal-title":"Front Behav Neurosci"},{"key":"3590_CR50","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0022-3565(25)21776-1","volume":"229","author":"C Rivier","year":"1984","unstructured":"Rivier C, Bruhn T, Vale W (1984) Effect of ethanol on the hypothalamic-pituitary-adrenal axis in the rat: role of corticotropin-releasing factor (CRF). J Pharmacol Exp Ther 229:127\u2013131","journal-title":"J Pharmacol Exp Ther"},{"key":"3590_CR51","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s002130051050","volume":"145","author":"JK Rowlett","year":"1999","unstructured":"Rowlett JK, Winger G, Carter RB, Wood PL, Woods JH, Woolverton WL (1999) Reinforcing and discriminative stimulus effects of the neuroactive steroids pregnanolone and Co 8-7071 in rhesus monkeys. Psychopharmacology 145:205\u2013212","journal-title":"Psychopharmacology"},{"key":"3590_CR52","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.psyneuen.2011.03.002","volume":"36","author":"ML Schwandt","year":"2011","unstructured":"Schwandt ML, Lindell SG, Higley JD, Suomi SJ, Heilig M, Barr CS (2011) OPRM1 gene variation influences hypothalamic-pituitary-adrenal axis function in response to a variety of stressors in rhesus macaques. Psychoneuroendocrinology 36:1303\u20131311","journal-title":"Psychoneuroendocrinology"},{"key":"3590_CR53","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1046\/j.1471-4159.2000.0750732.x","volume":"75","author":"M Serra","year":"2000","unstructured":"Serra M, Pisu MG, Littera M, Papi G, Sanna E, Tuveri F, Usala L, Purdy RH, Biggio G (2000) Social isolation-induced decreases in both the abundance of neuroactive steroids and GABAA receptor function in rat brain. J Neurochem 75:732\u2013740","journal-title":"J Neurochem"},{"key":"3590_CR54","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/npp.2008.78","volume":"34","author":"R Sinha","year":"2009","unstructured":"Sinha R, Fox HC, Hong KA, Bergquist K, Bhagwagar Z, Siedlarz KM (2009) Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals. Neuropsychopharmacology 34:1198\u20131208","journal-title":"Neuropsychopharmacology"},{"key":"3590_CR55","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/s00213-002-1123-1","volume":"162","author":"RS Sinnott","year":"2002","unstructured":"Sinnott RS, Phillips TJ, Finn DA (2002) Alteration of voluntary ethanol and saccharin consumption by the neurosteroid allopregnanolone in mice. Psychopharmacology 162:438\u2013447","journal-title":"Psychopharmacology"},{"key":"3590_CR56","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.yhbeh.2007.12.004","volume":"53","author":"AR Tyrka","year":"2008","unstructured":"Tyrka AR, Wier LM, Price LH, Rikhye K, Ross NS, Anderson GM, Wilkinson CW, Carpenter LL (2008) Cortisol and ACTH responses to the DEX\/CRH test: influence of temperament. Horm Behav 53:518\u2013525","journal-title":"Horm Behav"},{"key":"3590_CR57","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1530\/JOE-11-0178","volume":"211","author":"GP Vinson","year":"2011","unstructured":"Vinson GP (2011) The mislabeling of deoxycorticosterone: making sense of corticosteroid structure and function. J Endocrinol 211:3\u201316","journal-title":"J Endocrinol"},{"key":"3590_CR58","doi-asserted-by":"crossref","unstructured":"Vivian JA, Green HL, Young JE, Majerksy LS, Thomas BW, Shively CA, Tobin JR, Nader MA, Grant KA (2001) Induction and maintenance of alcohol self-administration in cynomolgus monkeys (Macaca fascicularis): long-term characterization of sex and individual differences. Alcohol Clin Exp Res 25:1087\u20131097","DOI":"10.1111\/j.1530-0277.2001.tb02321.x"},{"key":"3590_CR59","first-page":"518","volume":"77","author":"C Waltman","year":"1993","unstructured":"Waltman C, Blevins LS Jr, Boyd G, Wand GS (1993) The effects of mild ethanol intoxication on the hypothalamic-pituitary-adrenal axis in nonalcoholic men. J Clin Endocrinol Metab 77:518\u2013522","journal-title":"J Clin Endocrinol Metab"},{"key":"3590_CR60","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1210\/jcem-72-6-1290","volume":"72","author":"GS Wand","year":"1991","unstructured":"Wand GS, Dobs AS (1991) Alterations in the hypothalamic-pituitary-adrenal axis in actively drinking alcoholics. J Clin Endocrinol Metab 72:1290\u20131295","journal-title":"J Clin Endocrinol Metab"},{"key":"3590_CR61","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/sj.bjp.0706911","volume":"149","author":"MD Womack","year":"2006","unstructured":"Womack MD, Pyner S, Barrett-Jolley R (2006) Inhibition by alpha-tetrahydrodeoxycorticosterone (THDOC) of pre-sympathetic parvocellular neurones in the paraventricular nucleus of rat hypothalamus. Br J Pharmacol 149:600\u2013607","journal-title":"Br J Pharmacol"}],"updated-by":[{"DOI":"10.1007\/s00213-014-3679-y","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000}}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-014-3590-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-014-3590-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-014-3590-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T16:25:32Z","timestamp":1746203132000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-014-3590-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,1]]},"references-count":61,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["3590"],"URL":"https:\/\/doi.org\/10.1007\/s00213-014-3590-6","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s00213-014-3679-y","asserted-by":"object"}]},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,1]]}}}