{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:27:40Z","timestamp":1773289660849,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"24","license":[{"start":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T00:00:00Z","timestamp":1401321600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s00213-014-3624-0","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T12:25:29Z","timestamp":1401279929000},"page":"4703-4710","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A study of antioxidant activity in patients with schizophrenia taking atypical antipsychotics"],"prefix":"10.1007","volume":"231","author":[{"given":"Marilena","family":"Gilca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Piriu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corina","family":"Delia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liviu","family":"Iosif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeriu","family":"Atanasiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Stoian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,5,29]]},"reference":[{"key":"3624_CR1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4088\/JCP.v60n0402","volume":"60","author":"DB Allison","year":"1999","unstructured":"Allison DB, Fontaine KR, Heo M, Mentore JL, Cappelleri JC, Chandler LP et al (1999a) The distribution of body mass index among individuals with and without schizophrenia. J Clin Psychiatry 60:215\u2013220","journal-title":"J Clin Psychiatry"},{"key":"3624_CR2","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1176\/ajp.156.11.1686","volume":"156","author":"DB Allison","year":"1999","unstructured":"Allison DB, Mentore JL, Heo M, Chandler LP, Cappelleri JC, Infante MC et al (1999b) Antipsychotic-induced weight gain: a comprehensive research synthesis. Am J Psychiatry 156:1686\u20131696","journal-title":"Am J Psychiatry"},{"key":"3624_CR3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.amepre.2008.11.020","volume":"36","author":"DB Allison","year":"2009","unstructured":"Allison DB, Newcomer JW, Dunn AL, Blumenthal JA, Fabricatore AN, Daumit GL et al (2009) Obesity among those with mental disorders: a National Institute of Mental Health meeting report. Am J Prev Med 36:341\u2013350","journal-title":"Am J Prev Med"},{"key":"3624_CR4","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1161\/01.ATV.19.2.330","volume":"19","author":"A Ayub","year":"1999","unstructured":"Ayub A, Mackness MI, Arrol S, Mackness B, Patel J, Durrington PN (1999) Serum paraoxonase after myocardial infarction. Arterioscler Thromb Vasc Biol 19:330\u2013335","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"3624_CR5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/01.pra.0000388627.36781.6a","volume":"16","author":"MR Baig","year":"2010","unstructured":"Baig MR, Navaira E, Escamilla MA, Raventos H, Walss-Bass C (2010) Clozapine treatment causes oxidation of proteins involved in energy metabolism in lymphoblastoid cells: a possible mechanism for antipsychotic-induced metabolic alterations. J Psychiatr Pract 16(5):325\u2013333","journal-title":"J Psychiatr Pract"},{"key":"3624_CR6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2165\/00023210-200822060-00003","volume":"22","author":"T Baptista","year":"2008","unstructured":"Baptista T, ElFakih Y, Uzcategui E, Sandia I, Talamo E, Araujo de Baptist et al (2008) Pharmacological management of atypical antipsychotic-induced weight gain. CNS Drugs 22:477\u2013495","journal-title":"CNS Drugs"},{"key":"3624_CR7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/10715769800300171","volume":"29","author":"A Dalla Libera","year":"1998","unstructured":"Dalla Libera A, Scutari G, Boscolo R, Rigobello MP, Bindoli A (1998) Antioxidant properties of clozapine and related neuroleptics. Free Radic Res 29:151\u2013157","journal-title":"Free Radic Res"},{"key":"3624_CR8","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.ATV.21.4.473","volume":"21","author":"PN Durrington","year":"2001","unstructured":"Durrington PN, Mackness B, Mackness MI (2001) Paraoxonase and atherosclerosis. Arterioscler Thromb Vasc Biol 21:473\u2013480","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"3624_CR9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/07315724.2011.10719971","volume":"30","author":"A Esfahani","year":"2011","unstructured":"Esfahani A, Wong JMW, Truan J, Villa CR, Mirrahimi A, Srichaikul K et al (2011) Health effects of mixed fruit and vegetable concentrates: a systematic review of the clinical interventions. J Am Coll Nutr 30:285\u2013294","journal-title":"J Am Coll Nutr"},{"issue":"5","key":"3624_CR10","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/01.jcp.0000177668.42640.fe","volume":"25","author":"K Fehsel","year":"2005","unstructured":"Fehsel K, Loeffler S, Krieger K, Henning U, Agelink M, Kolb-Bachofen V et al (2005) Clozapine induces oxidative stress and proapoptotic gene expression in neutrophils of schizophrenic patients. J Clin Psychopharmacol 25(5):419\u2013426","journal-title":"J Clin Psychopharmacol"},{"key":"3624_CR11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1192\/bjp.174.3.273b","volume":"174","author":"MB First","year":"1999","unstructured":"First MB, Pincus HA (1999) Definitions of schizophrenia. Br J Psychiatry 174:273","journal-title":"Br J Psychiatry"},{"key":"3624_CR12","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1194\/jlr.D600045-JLR200","volume":"48","author":"L Gaidukov","year":"2007","unstructured":"Gaidukov L, Tawfik DS (2007) The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity. J Lipid Res 48:1637\u20131646","journal-title":"J Lipid Res"},{"key":"3624_CR13","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.pnpbp.2005.11.009","volume":"30","author":"CS Gama","year":"2006","unstructured":"Gama CS, Salvador M, Andreazza AC, Kapczinski F, Silva B (2006) Elevated serum superoxide dismutase and thiobarbituric acid reactive substances in schizophrenia: a study of patients treated with haloperidol or clozapine. Prog Neuropsychopharmacol Biol Psychiatry 30:512\u2013515","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3624_CR14","first-page":"391","volume":"30","author":"L Haagen","year":"1992","unstructured":"Haagen L, Brock A (1992) A new automated method for phenotyping arylesterase (EC 3.1.1.2) based upon inhibition of enzymatic hydrolysis of 4-nitrophenyl acetate by phenyl acetate. Eur J Clin Chem Clin Biochem 30:391\u2013395","journal-title":"Eur J Clin Chem Clin Biochem"},{"issue":"1","key":"3624_CR15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1001\/archpsyc.62.1.19","volume":"62","author":"DC Henderson","year":"2005","unstructured":"Henderson DC, Cagliero E, Copeland PM, Borba CP, Evins E, Hayden D, Weber MT, Anderson EJ, Allison DB, Daley TB, Schoenfeld D, Goff DC (2005) Glucose metabolism in patients with schizophrenia treated with atypical antipsychotic agents: a frequently sampled intravenous glucose tolerance test and minimal model analysis. Arch Gen Psychiatry 62(1):19\u201328","journal-title":"Arch Gen Psychiatry"},{"key":"3624_CR16","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1161\/01.ATV.20.11.2441","volume":"20","author":"GP Jarvik","year":"2000","unstructured":"Jarvik GP, Rozek LS, Brophy VH, Hatsukami TS, Richter RJ, Schellenberg GD et al (2000) Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype. Arterioscler Thromb Vasc Biol 20:2441\u20132447","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"3624_CR17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0009-8981(90)90162-L","volume":"188","author":"H Kawai","year":"1990","unstructured":"Kawai H, Sakamoto F, Inoue Y (1990) Improved specific assay for serum arylesterase using a water-soluble substrate. Clin Chim Acta 188:177\u2013182","journal-title":"Clin Chim Acta"},{"key":"3624_CR18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/07315724.2011.10719976","volume":"30","author":"P Koncsos","year":"2011","unstructured":"Koncsos P, Seres I, Harangi M, P\u00e1ll D, J\u00f3zsa L, Bajnok L et al (2011) Favorable effect of short-term lifestyle intervention on human paraoxonase-1 activity and adipokine levels in childhood obesity. J Am Coll Nutr 30:333\u2013339","journal-title":"J Am Coll Nutr"},{"issue":"9","key":"3624_CR19","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1161\/hq0901.094247","volume":"21","author":"B Mackness","year":"2001","unstructured":"Mackness B, Davies GK, Turkie W, Lee E, Roberts DH, Hill E et al (2001) Paraoxonase status in coronary heart disease: are activity and concentration more important than genotype? Arterioscler Thromb Vasc Biol 21(9):1451\u20131457","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"3624_CR20","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1161\/01.CIR.0000070954.00271.13","volume":"107","author":"B Mackness","year":"2003","unstructured":"Mackness B, Durrington P, McElduff P, Yarnell J, Azam N, Watt M et al (2003) Low paraoxonase activity predicts coronary events in the Caerphilly Prospective Study. Circulation 107:2775\u20132779","journal-title":"Circulation"},{"key":"3624_CR21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/13510002.1996.11747044","volume":"2","author":"NJ Miller","year":"1996","unstructured":"Miller NJ, Rice-Evans C (1996) Spectrophotometric determination of antioxidant activity. Redox Rep 2:161\u2013171","journal-title":"Redox Rep"},{"key":"3624_CR22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1177\/000456329703400113","volume":"34","author":"NJ Miller","year":"1997","unstructured":"Miller NJ, Johnston JD, Collis CS, Rice-Evans C (1997) Serum total antioxidant activity after myocardial infarction. Ann Clin Biochem 34:85\u201390","journal-title":"Ann Clin Biochem"},{"key":"3624_CR23","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1172\/JCI119369","volume":"99","author":"M Navab","year":"1997","unstructured":"Navab M, Hama-Levy S, Van Lenten BJ, Fonarow GC, Cardinez CJ, Castellani LW et al (1997) Mildly oxidized LDL induces an increased apolipoprotein J\/paraoxonase ratio. J Clin Invest 99:2005\u20132019","journal-title":"J Clin Invest"},{"key":"3624_CR24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1590\/S1807-59322008000500014","volume":"63","author":"A Ozenoglu","year":"2008","unstructured":"Ozenoglu A, Balci H, Ugurlu S, Caglar E, Uzun H, Sarkis C et al (2008) The relationships of leptin, adiponectin levels and paraoxonase activity with metabolic and cardiovascular risk factors in females treated with psychiatric drugs. Clinics (Sao Paulo) 63:651\u2013660","journal-title":"Clinics (Sao Paulo)"},{"key":"3624_CR25","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000045489","volume":"83","author":"G Paragh","year":"1999","unstructured":"Paragh G, Asztalos L, Seres I, Balogh Z, Locsey L, Karpati I et al (1999) Serum paraoxonase activity changes in uremic and kidney-transplanted patients. Nephron 83:126\u2013131","journal-title":"Nephron"},{"key":"3624_CR26","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jpsychires.2006.01.011","volume":"41","author":"A Pillai","year":"2007","unstructured":"Pillai A, Parikh V, Terry AV, Mahadik SP (2007) Long-term antipsychotic treatments and crossover studies in rats: differential effects of typical and atypical agents on the expression of antioxidant enzymes and membrane lipid peroxidation in rat brain. J Psychiatr Res 41:372\u2013386","journal-title":"J Psychiatr Res"},{"key":"3624_CR27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.atherosclerosis.2010.08.076","volume":"214","author":"LP Precourt","year":"2011","unstructured":"Precourt LP, Amre D, Denis MC, Lavoie JC, Delvin E, Seidman E et al (2011) The three-gene paraoxonase family: physiologic roles, actions and regulation. Atherosclerosis 214:20\u201336","journal-title":"Atherosclerosis"},{"key":"3624_CR28","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/thorax.55.3.189","volume":"55","author":"I Rahman","year":"2000","unstructured":"Rahman I, Swarskaa E, Henry M, Stolk I, MacNee W (2000) Is there any relationship between plasma antioxidant capacity and lung function in smokers and in patients with chronic obstructive pulmonary disease? Thorax 55:189\u2013193","journal-title":"Thorax"},{"key":"3624_CR29","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1093\/jn\/131.10.3012","volume":"132","author":"M Rantala","year":"2002","unstructured":"Rantala M, Silaste ML, Tuominen A, Kaikkonen J, Salonen JT, Alfthan G et al (2002) Dietary modifications and gene polymorphisms alter serum paraoxonase activity in healthy women. J Nutr 132:3012\u20133017","journal-title":"J Nutr"},{"key":"3624_CR30","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","volume":"26","author":"R Re","year":"1999","unstructured":"Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C (1999) Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26:1231\u20131237","journal-title":"Free Radic Biol Med"},{"key":"3624_CR31","first-page":"Unit4","volume":"Chapter 4","author":"RJ Richter","year":"2004","unstructured":"Richter RJ, Jampsa RL, Jarvik GP, Costa LG, Furlong CE (2004) Determination of paraoxonase 1 status and genotypes at specific polymorphic sites. Curr Protoc Toxicol Chapter 4:Unit4","journal-title":"Curr Protoc Toxicol"},{"key":"3624_CR32","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0013-7006(05)82412-1","volume":"31","author":"O Ruetsch","year":"2005","unstructured":"Ruetsch O, Viala A, Bardou H, Martin P, Vacheron MN (2005) Psychotropic drugs induced weight gain: a review of the literature concerning epidemiological data, mechanisms and management. Enc\u00e9phale 31:507\u2013516","journal-title":"Enc\u00e9phale"},{"key":"3624_CR33","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1176\/appi.neuropsych.17.2.227","volume":"17","author":"S Stefan Kropp","year":"2005","unstructured":"Stefan Kropp S, Kern V, Lange K, Degner D, Hajak G, Kornhuber J et al (2005) Oxidative stress during treatment with first- and second-generation antipsychotics. J Neuropsychiatry Clin Neurosci 17:227\u2013231","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"3624_CR34","first-page":"1545","volume":"9","author":"C \u00dcnsal","year":"2013","unstructured":"\u00dcnsal C, Albayrak Y, Albayrak N, Kuloglu M, Hashimoto K (2013) Reduced serum paraoxonase 1 (PON1) activity in patients with schizophrenia treated with olanzapine but not quetiapine. Neuropsychiatr Dis Treat 9:1545\u20131552","journal-title":"Neuropsychiatr Dis Treat"},{"key":"3624_CR35","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.2337\/diacare.24.9.1608","volume":"24","author":"J Valabhji","year":"2001","unstructured":"Valabhji J, Mccoll AJ, Richmond W, Schachter M, Rubens MB, Elkeles RS (2001) Total antioxidant status and coronary artery calcification in type 1 diabetes. Diabetes Care 24:1608\u20131613","journal-title":"Diabetes Care"},{"key":"3624_CR36","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(12)60312-2","volume":"380","author":"BF Voight","year":"2012","unstructured":"Voight BF, Peloso GM, Orho-Melander M, Frikke-Schmidt R, Barbalic M, Jensen MK et al (2012) Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet 380:572\u2013580","journal-title":"Lancet"},{"issue":"8","key":"3624_CR37","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1017\/S1461145708008882","volume":"11","author":"C Walss-Bass","year":"2008","unstructured":"Walss-Bass C, Weintraub ST, Hatch J, Mintz J, Chaudhuri AR (2008) Clozapine causes oxidation of proteins involved in energy metabolism: a possible mechanism for antipsychotic-induced metabolic alterations. Int J Neuropsychopharmacol 11(8):1097\u20131104","journal-title":"Int J Neuropsychopharmacol"},{"key":"3624_CR38","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1001\/archpsyc.1990.01810180089012","volume":"47","author":"JK Wing","year":"1990","unstructured":"Wing JK, Babor T, Brugha T, Burke J, Cooper JE, Giel R et al (1990) SCAN. Schedules for clinical assessment in neuropsychiatry. Arch Gen Psychiatry 47:589\u2013593","journal-title":"Arch Gen Psychiatry"},{"key":"3624_CR39","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/gepi.20191","volume":"31","author":"DA Winnier","year":"2007","unstructured":"Winnier DA, Rainwater DL, Cole SA, Williams JT, Dyer TD, Blangero J et al (2007) Sex-specific QTL effects on variation in paraoxonase 1 (PON1) activity in Mexican Americans. Genet Epidemiol 31:66\u201374","journal-title":"Genet Epidemiol"},{"key":"3624_CR40","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.schres.2005.10.011","volume":"81","author":"XY Zhang","year":"2006","unstructured":"Zhang XY, Tan YL, Cao LY, Wu GY, Xu Q, Shen Y et al (2006) Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics. Schizophr Res 81:291\u2013300","journal-title":"Schizophr Res"},{"issue":"5\u20136","key":"3624_CR41","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.neuropharm.2011.12.014","volume":"62","author":"XY Zhang","year":"2012","unstructured":"Zhang XY, Zhou DF, Shen YC, Zhang PY, Zhang WF, Liang J et al (2012) Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia. Neuropharmacology 62(5\u20136):1928\u20131934","journal-title":"Neuropharmacology"},{"key":"3624_CR42","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1007\/s00213-013-3410-4","volume":"231","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, Chen M, Chen J, Wu Z, Yu S, Fang Y, Zhang C (2014) Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype. Psychopharmacology (Berlin) 231:2211\u20132218","journal-title":"Psychopharmacology (Berlin)"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-014-3624-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-014-3624-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-014-3624-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T18:51:57Z","timestamp":1689274317000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-014-3624-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,29]]},"references-count":42,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["3624"],"URL":"https:\/\/doi.org\/10.1007\/s00213-014-3624-0","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,29]]}}}