{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:41:56Z","timestamp":1791330116716,"version":"4.3.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"18","license":[{"start":{"date-parts":[[2014,7,20]],"date-time":"2014-07-20T00:00:00Z","timestamp":1405814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s00213-014-3664-5","type":"journal-article","created":{"date-parts":[[2014,7,19]],"date-time":"2014-07-19T01:22:37Z","timestamp":1405732957000},"page":"3663-3676","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":290,"title":["Ketamine administration in depressive disorders: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"231","author":[{"given":"Guillaume","family":"Fond","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson","family":"Loundou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corentin","family":"Rabu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Macgregor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Lan\u00e7on","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Brittner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Arthur","family":"Micoulaud-Franchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphaelle","family":"Richieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Courtet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mocrane","family":"Abbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Roger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Leboyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,20]]},"reference":[{"key":"3664_CR1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/YCT.0b013e31824f8296","volume":"28","author":"CG Abdallah","year":"2012","unstructured":"Abdallah CG, Fasula M, Kelmendi B, Sanacora G, Ostroff R (2012) Rapid antidepressant effect of ketamine in the electroconvulsive therapy setting. J ECT 28:157\u2013161","journal-title":"J ECT"},{"key":"3664_CR2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0006-3223(99)00230-9","volume":"47","author":"RM Berman","year":"2000","unstructured":"Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH (2000) Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 47:351\u2013354","journal-title":"Biol Psychiatry"},{"key":"3664_CR3","doi-asserted-by":"crossref","DOI":"10.1002\/9780470743386","volume-title":"Introduction to meta-analysis","author":"M Borenstein","year":"2009","unstructured":"Borenstein M, Hedges LV, Higgins JPT, Rothstein HR (2009) Introduction to meta-analysis. Wiley, Chichester"},{"key":"3664_CR4","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1192\/bjp.120.559.679","volume":"120","author":"CL Brewer","year":"1972","unstructured":"Brewer CL, Davidson JR, Hereward S (1972) Ketamine (\u201cKetalar\u201d): a safer anaesthetic for ECT. Br J Psychiatry 120:679\u2013680","journal-title":"Br J Psychiatry"},{"key":"3664_CR5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1399-5618.2007.00500.x","volume":"10","author":"JR Calabrese","year":"2008","unstructured":"Calabrese JR, Huffman RF, White RL, Edwards S, Thompson TR, Ascher JA, Monaghan ET, Leadbetter RA (2008) Lamotrigine in the acute treatment of bipolar depression: results of five double-blind, placebo-controlled clinical trials. Bipolar Disord 10:323\u2013333","journal-title":"Bipolar Disord"},{"key":"3664_CR6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/475027a","volume":"475","author":"PY Collins","year":"2011","unstructured":"Collins PY, Patel V, Joestl SS, March D, Insel TR, Daar AS, Scientific Advisory B, the Executive Committee of the Grand Challenges on Global Mental H, Anderson W, Dhansay MA, Phillips A, Shurin S, Walport M, Ewart W, Savill SJ, Bordin IA, Costello EJ, Durkin M, Fairburn C, Glass RI, Hall W, Huang Y, Hyman SE, Jamison K, Kaaya S, Kapur S, Kleinman A, Ogunniyi A, Otero-Ojeda A, Poo MM, Ravindranath V, Sahakian BJ, Saxena S, Singer PA, Stein DJ (2011) Grand challenges in global mental health. Nature 475:27\u201330","journal-title":"Nature"},{"key":"3664_CR7","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1176\/appi.ajp.2012.12020219","volume":"169","author":"C Cusin","year":"2012","unstructured":"Cusin C, Hilton GQ, Nierenberg AA, Fava M (2012) Long-term maintenance with intramuscular ketamine for treatment-resistant bipolar II depression. Am J Psychiatry 169:868\u2013869","journal-title":"Am J Psychiatry"},{"key":"3664_CR8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","volume":"7","author":"R DerSimonian","year":"1986","unstructured":"DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177\u2013188","journal-title":"Control Clin Trials"},{"key":"3664_CR9","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1001\/archgenpsychiatry.2010.90","volume":"67","author":"N Diazgranados","year":"2010","unstructured":"Diazgranados N, Ibrahim L, Brutsche NE, Newberg A, Kronstein P, Khalife S, Kammerer WA, Quezado Z, Luckenbaugh DA, Salvadore G, Machado-Vieira R, Manji HK, Zarate CA Jr (2010) A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression. Arch Gen Psychiatry 67:793\u2013802","journal-title":"Arch Gen Psychiatry"},{"key":"3664_CR10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.psychres.2013.12.008","volume":"215","author":"M Ghasemi","year":"2014","unstructured":"Ghasemi M, Kazemi MH, Yoosefi A, Ghasemi A, Paragomi P, Amini H, Afzali MH (2014) Rapid antidepressant effects of repeated doses of ketamine compared with electroconvulsive therapy in hospitalized patients with major depressive disorder. Psychiatry Res 215:355\u2013361","journal-title":"Psychiatry Res"},{"key":"3664_CR11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1192\/bjp.122.1.123-a","volume":"122","author":"CD Green","year":"1973","unstructured":"Green CD (1973) Ketamine as an anaesthetic for ECT. Br J Psychiatry 122:123\u2013124","journal-title":"Br J Psychiatry"},{"key":"3664_CR12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1212\/01.wnl.0000342200.58823.6a","volume":"72","author":"RA Gross","year":"2009","unstructured":"Gross RA, Johnston KC (2009) Levels of evidence: taking neurology to the next level. Neurology 72:8\u201310","journal-title":"Neurology"},{"key":"3664_CR13","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4103\/0019-5545.111461","volume":"55","author":"C Harihar","year":"2013","unstructured":"Harihar C, Dasari P, Srinivas JS (2013) Intramuscular ketamine in acute depression: a report on two cases. Indian J Psychiatry 55:186\u2013188","journal-title":"Indian J Psychiatry"},{"key":"3664_CR14","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JP Higgins","year":"2003","unstructured":"Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557\u2013560","journal-title":"BMJ"},{"key":"3664_CR15","unstructured":"Higgins JPT, Altman DG, Sterne JAC (2011) Assessing risk of bias in included studies. In J. P. T. Higgins, & S. Green (Eds.), Cochrane handbook for systematic reviews of interventions version 5.1.0 (updated March 2011). The Cochrane Collaboration"},{"key":"3664_CR16","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/YCT.0b013e318283b7e9","volume":"29","author":"K Jarventausta","year":"2013","unstructured":"Jarventausta K, Chrapek W, Kampman O, Tuohimaa K, Bjorkqvist M, Hakkinen H, Yli-Hankala A, Leinonen E (2013) Effects of S-ketamine as an anesthetic adjuvant to propofol on treatment response to electroconvulsive therapy in treatment-resistant depression: a randomized pilot study. J ECT 29:158\u2013161","journal-title":"J ECT"},{"issue":"Suppl 1","key":"3664_CR17","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1097\/00005344-200110001-00009","volume":"38","author":"H Kitagawa","year":"2001","unstructured":"Kitagawa H, Yamazaki T, Akiyama T, Mori H, Sunagawa K (2001) Effects of ketamine on in vivo cardiac sympathetic nerve endings. J Cardiovasc Pharmacol 38(Suppl 1):S39\u2013S42","journal-title":"J Cardiovasc Pharmacol"},{"key":"3664_CR18","doi-asserted-by":"crossref","unstructured":"Kranaster L, Hoyer C, Janke C, Sartorius A (2011) Preliminary evaluation of clinical outcome and safety of ketamine as an anesthetic for electroconvulsive therapy in schizophrenia. World J Biol Psychiatry","DOI":"10.3109\/15622975.2011.647833"},{"key":"3664_CR19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1176\/appi.neuropsych.15.1.27","volume":"15","author":"AD Krystal","year":"2003","unstructured":"Krystal AD, Weiner RD, Dean MD, Lindahl VH, Tramontozzi LA 3rd, Falcone G, Coffey CE (2003) Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT. J Neuropsychiatry Clin Neurosci 15:27\u201334","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"3664_CR20","doi-asserted-by":"crossref","unstructured":"Kudoh A, Takahira Y, Katagai H, Takazawa T (2002) Small-dose ketamine improves the postoperative state of depressed patients. Anesth Analg 95:114\u2013118","DOI":"10.1097\/00000539-200207000-00020"},{"key":"3664_CR21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jad.2012.04.032","volume":"142","author":"CK Loo","year":"2012","unstructured":"Loo CK, Katalinic N, Garfield JB, Sainsbury K, Hadzi-Pavlovic D, Mac-Pherson R (2012) Neuropsychological and mood effects of ketamine in electroconvulsive therapy: a randomised controlled trial. J Affect Disord 142:233\u2013240","journal-title":"J Affect Disord"},{"key":"3664_CR22","first-page":"719","volume":"22","author":"N Mantel","year":"1959","unstructured":"Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719\u2013748","journal-title":"J Natl Cancer Inst"},{"key":"3664_CR23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00124509-200606000-00005","volume":"22","author":"WW McDaniel","year":"2006","unstructured":"McDaniel WW, Sahota AK, Vyas BV, Laguerta N, Hategan L, Oswald J (2006) Ketamine appears associated with better word recall than etomidate after a course of 6 electroconvulsive therapies. J ECT 22:103\u2013106","journal-title":"J ECT"},{"key":"3664_CR24","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","volume":"339","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 339:b2535","journal-title":"BMJ"},{"key":"3664_CR25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1360-0443.2011.03576.x","volume":"107","author":"CJ Morgan","year":"2011","unstructured":"Morgan CJ, Curran HV (2011) Ketamine use: a review. Addiction 107:27\u201338","journal-title":"Addiction"},{"key":"3664_CR26","doi-asserted-by":"crossref","unstructured":"Murrough JW, Iosifescu DV, Chang LC, Al Jurdi RK, Green CM, Perez AM, Iqbal S, Pillemer S, Foulkes A, Shah A, Charney DS, Mathew SJ (2013) Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. Am J Psychiatry","DOI":"10.1176\/appi.ajp.2013.13030392"},{"key":"3664_CR27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/YCT.0b013e3181c3b0aa","volume":"26","author":"N Okamoto","year":"2010","unstructured":"Okamoto N, Nakai T, Sakamoto K, Nagafusa Y, Higuchi T, Nishikawa T (2010) Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia. J ECT 26:223\u2013227","journal-title":"J ECT"},{"key":"3664_CR28","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1176\/appi.ajp.163.11.1905","volume":"163","author":"AJ Rush","year":"2006","unstructured":"Rush AJ, Trivedi MH, Wisniewski SR, Nierenberg AA, Stewart JW, Warden D, Niederehe G, Thase ME, Lavori PW, Lebowitz BD, McGrath PJ, Rosenbaum JF, Sackeim HA, Kupfer DJ, Luther J, Fava M (2006) Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry 163:1905\u20131917","journal-title":"Am J Psychiatry"},{"key":"3664_CR29","first-page":"287","volume":"34","author":"P Sos","year":"2013","unstructured":"Sos P, Klirova M, Novak T, Kohutova B, Horacek J, Palenicek T (2013) Relationship of ketamine\u2019s antidepressant and psychotomimetic effects in unipolar depression. Neuro Endocrinol Lett 34:287\u2013293","journal-title":"Neuro Endocrinol Lett"},{"issue":"Suppl 6","key":"3664_CR30","first-page":"16","volume":"67","author":"D Souery","year":"2006","unstructured":"Souery D, Papakostas GI, Trivedi MH (2006) Treatment-resistant depression. J Clin Psychiatry 67(Suppl 6):16\u201322","journal-title":"J Clin Psychiatry"},{"key":"3664_CR31","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pscychresns.2010.10.009","volume":"191","author":"GW Valentine","year":"2011","unstructured":"Valentine GW, Mason GF, Gomez R, Fasula M, Watzl J, Pittman B, Krystal JH, Sanacora G (2011) The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS. Psychiatry Res 191:122\u2013127","journal-title":"Psychiatry Res"},{"key":"3664_CR32","doi-asserted-by":"crossref","unstructured":"Vassos E, Collier DA, Fazel S (2013) Systematic meta-analyses and field synopsis of genetic association studies of violence and aggression. Mol Psychiatry","DOI":"10.1038\/mp.2013.31"},{"key":"3664_CR33","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/YCT.0b013e31824d1d02","volume":"28","author":"X Wang","year":"2012","unstructured":"Wang X, Chen Y, Zhou X, Liu F, Zhang T, Zhang C (2012) Effects of propofol and ketamine as combined anesthesia for electroconvulsive therapy in patients with depressive disorder. J ECT 28:128\u2013132","journal-title":"J ECT"},{"key":"3664_CR34","doi-asserted-by":"crossref","unstructured":"Zarate CA Jr, Brutsche NE, Ibrahim L, Franco-Chaves J, Diazgranados N, Cravchik A, Selter J, Marquardt CA, Liberty V, Luckenbaugh DA (2012) Replication of ketamine\u2019s antidepressant efficacy in bipolar depression: a randomized controlled add-on trial. Biol Psychiatry","DOI":"10.1016\/j.biopsych.2011.12.010"},{"key":"3664_CR35","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","volume":"63","author":"CA Zarate Jr","year":"2006","unstructured":"Zarate CA Jr, Singh JB, Carlson PJ, Brutsche NE, Ameli R, Luckenbaugh DA, Charney DS, Manji HK (2006) A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 63:856\u2013864","journal-title":"Arch Gen Psychiatry"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-014-3664-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-014-3664-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-014-3664-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T20:54:02Z","timestamp":1565643242000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-014-3664-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,20]]},"references-count":35,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["3664"],"URL":"https:\/\/doi.org\/10.1007\/s00213-014-3664-5","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718498368.793500048","asserted-by":"object"}]},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,20]]}}}