{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:47:26Z","timestamp":1783730846587,"version":"3.55.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T00:00:00Z","timestamp":1414713600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1007\/s00213-014-3785-x","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T05:02:15Z","timestamp":1414645335000},"page":"1527-1533","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Striatal dopamine D1 and D2 receptors are differentially regulated following buprenorphine or methadone treatment"],"prefix":"10.1007","volume":"232","author":[{"given":"St\u00e9phane","family":"Allouche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Le Marec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Coquerel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Noble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Marie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,10,31]]},"reference":[{"key":"3785_CR1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.pnpbp.2012.10.013","volume":"40","author":"S Allouche","year":"2013","unstructured":"Allouche S, Le Marec T, Noble F et al (2013) Different patterns of administration modulate propensity of methadone and buprenorphine to promote locomotor sensitization in mice. Prog Neuropsychopharmacol Biol Psychiatry 40:286\u2013291","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3785_CR2","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1046\/j.1471-4159.1995.65041636.x","volume":"65","author":"JR Arden","year":"1995","unstructured":"Arden JR, Segredo V, Wang Z et al (1995) Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged mu-opioid receptor expressed in HEK 293 cells. J Neurochem 65:1636\u20131645","journal-title":"J Neurochem"},{"key":"3785_CR3","first-page":"152","volume":"7","author":"JH Baik","year":"2013","unstructured":"Baik JH (2013) Dopamine signaling in reward-related behaviors. Front Neural Circ 7:152","journal-title":"Front Neural Circ"},{"key":"3785_CR4","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1124\/pr.110.002642","volume":"63","author":"JM Beaulieu","year":"2011","unstructured":"Beaulieu JM, Gainetdinov RR (2011) The physiology, signaling, and pharmacology of dopamine receptors. Pharmacol Rev 63:182\u2013217","journal-title":"Pharmacol Rev"},{"key":"3785_CR5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejphar.2013.04.015","volume":"711","author":"E Belkai","year":"2013","unstructured":"Belkai E, Crete D, Courtin C et al (2013) Comparison of the transcriptional responses induced by acute morphine, methadone and buprenorphine. Eur J Pharmacol 711:10\u201318","journal-title":"Eur J Pharmacol"},{"key":"3785_CR6","doi-asserted-by":"crossref","first-page":"18776","DOI":"10.1074\/jbc.M300525200","volume":"278","author":"SL Borgland","year":"2003","unstructured":"Borgland SL, Connor M, Osborne PB et al (2003) Opioid agonists have different efficacy profiles for G protein activation, rapid desensitization, and endocytosis of mu-opioid receptors. J Biol Chem 278:18776\u201318784","journal-title":"J Biol Chem"},{"key":"3785_CR7","doi-asserted-by":"crossref","first-page":"12655","DOI":"10.1523\/JNEUROSCI.3926-07.2007","volume":"27","author":"JM Bossert","year":"2007","unstructured":"Bossert JM, Poles GC, Wihbey KA et al (2007) Differential effects of blockade of dopamine D1-family receptors in nucleus accumbens core or shell on reinstatement of heroin seeking induced by contextual and discrete cues. J Neurosci 27:12655\u201312663","journal-title":"J Neurosci"},{"key":"3785_CR8","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1073\/pnas.86.6.1741","volume":"86","author":"G Charpak","year":"1989","unstructured":"Charpak G, Dominik W, Zaganidis N (1989) Optical imaging of the spatial distribution of beta-particles emerging from surfaces. Proc Natl Acad Sci U S A 86:1741\u20131745","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3785_CR9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0014-2999(99)00372-6","volume":"375","author":"G Chiara Di","year":"1999","unstructured":"Di Chiara G (1999) Drug addiction as dopamine-dependent associative learning disorder. Eur J Pharmacol 375:13\u201330","journal-title":"Eur J Pharmacol"},{"key":"3785_CR10","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/emboj.2011.400","volume":"31","author":"PF Durieux","year":"2012","unstructured":"Durieux PF, Schiffmann SN, de Kerchove D et al (2012) Differential regulation of motor control and response to dopaminergic drugs by D1R and D2R neurons in distinct dorsal striatum subregions. EMBO J 31:640\u2013653","journal-title":"EMBO J"},{"key":"3785_CR11","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0896-6273(01)00517-7","volume":"32","author":"AK Finn","year":"2001","unstructured":"Finn AK, Whistler JL (2001) Endocytosis of the mu opioid receptor reduces tolerance and a cellular hallmark of opiate withdrawal. Neuron 32:829\u2013839","journal-title":"Neuron"},{"key":"3785_CR12","volume-title":"The mouse brain in stereotaxic coordinates","author":"KBJ Franklin","year":"1997","unstructured":"Franklin KBJ, Paxinos G (1997) The mouse brain in stereotaxic coordinates. Academic, San Diego"},{"key":"3785_CR13","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1080\/10826080902810251","volume":"44","author":"G Gerra","year":"2009","unstructured":"Gerra G, Maremmani I, Capovani B et al (2009) Long-acting opioid-agonists in the treatment of heroin addiction: why should we call them substitution? Subst Use Misuse 44:663\u2013671","journal-title":"Subst Use Misuse"},{"key":"3785_CR14","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/ar.22457","volume":"295","author":"H Hou","year":"2012","unstructured":"Hou H, Tian M, Zhang H (2012) Positron emission tomography molecular imaging of dopaminergic system in drug addiction. Anat Rec (Hoboken) 295:722\u2013733","journal-title":"Anat Rec (Hoboken)"},{"key":"3785_CR15","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0022-3565(24)29586-0","volume":"297","author":"P Huang","year":"2001","unstructured":"Huang P, Kehner GB, Cowan A et al (2001) Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist. J Pharmacol Exp Ther 297:688\u2013695","journal-title":"J Pharmacol Exp Ther"},{"key":"3785_CR16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0014-2999(94)00779-7","volume":"275","author":"M Jeziorski","year":"1995","unstructured":"Jeziorski M, White FJ (1995) Dopamine receptor antagonists prevent expression, but not development, of morphine sensitization. Eur J Pharmacol 275:235\u2013244","journal-title":"Eur J Pharmacol"},{"key":"3785_CR17","doi-asserted-by":"crossref","first-page":"19021","DOI":"10.1074\/jbc.271.32.19021","volume":"271","author":"DE Keith","year":"1996","unstructured":"Keith DE, Murray SR, Zaki PA et al (1996) Morphine activates opioid receptors without causing their rapid internalization. J Biol Chem 271:19021\u201319024","journal-title":"J Biol Chem"},{"key":"3785_CR18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00213-011-2223-6","volume":"216","author":"T Marec Le","year":"2011","unstructured":"Le Marec T, Marie-Claire C, Noble F et al (2011) Chronic and intermittent morphine treatment differently regulates opioid and dopamine systems: a role in locomotor sensitization. Psychopharmacology (Berl) 216:297\u2013303","journal-title":"Psychopharmacology (Berl)"},{"key":"3785_CR19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0022-3565(25)32504-8","volume":"217","author":"GS Ling","year":"1981","unstructured":"Ling GS, Umans JG, Inturrisi CE (1981) Methadone: radioimmunoassay and pharmacokinetics in the rat. J Pharmacol Exp Ther 217:147\u2013151","journal-title":"J Pharmacol Exp Ther"},{"key":"3785_CR20","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1001\/jama.2010.1427","volume":"304","author":"W Ling","year":"2010","unstructured":"Ling W, Casadonte P, Bigelow G et al (2010) Buprenorphine implants for treatment of opioid dependence: a randomized controlled trial. JAMA 304:1576\u20131583","journal-title":"JAMA"},{"key":"3785_CR21","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2174\/1570159043359477","volume":"2","author":"K Lutfy","year":"2004","unstructured":"Lutfy K, Cowan A (2004) Buprenorphine: a unique drug with complex pharmacology. Curr Neuropharmacol 2:395\u2013402","journal-title":"Curr Neuropharmacol"},{"key":"3785_CR22","doi-asserted-by":"crossref","unstructured":"Mattick RP, Breen C, Kimber J, Davoli M (2014) Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence. Cochrane Database Syst Rev 2: CD002207","DOI":"10.1002\/14651858.CD002207.pub4"},{"key":"3785_CR23","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0028-3908(98)00089-6","volume":"37","author":"T May","year":"1998","unstructured":"May T, Juilfs F, Wolffgramm J (1998) Long-lasting effects of chronic mu-opioid intake on the signal transmission via dopamine D1 receptors in the limbic forebrain of drug deprived rats. Neuropharmacology 37:997\u20131006","journal-title":"Neuropharmacology"},{"key":"3785_CR24","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1124\/mol.110.066613","volume":"78","author":"J McPherson","year":"2010","unstructured":"McPherson J, Rivero G, Baptist M et al (2010) Mu-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization. Mol Pharmacol 78:756\u2013766","journal-title":"Mol Pharmacol"},{"key":"3785_CR25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/(SICI)1098-2396(199711)27:3<262::AID-SYN10>3.0.CO;2-W","volume":"27","author":"P Nestby","year":"1997","unstructured":"Nestby P, Schotte A, Janssen PF et al (1997) Striatal dopamine receptors in rats displaying long-term behavioural sensitization to morphine. Synapse 27:262\u2013265","journal-title":"Synapse"},{"key":"3785_CR26","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.1476-5381.2012.02075.x","volume":"167","author":"AA Pradhan","year":"2012","unstructured":"Pradhan AA, Smith ML, Kieffer BL et al (2012) Ligand-directed signalling within the opioid receptor family. Br J Pharmacol 167:960\u2013969","journal-title":"Br J Pharmacol"},{"key":"3785_CR27","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0026-895X(25)09932-8","volume":"45","author":"K Raynor","year":"1994","unstructured":"Raynor K, Kong H, Chen Y et al (1994) Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol 45:330\u2013334","journal-title":"Mol Pharmacol"},{"key":"3785_CR28","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1111\/add.12315","volume":"108","author":"RN Rosenthal","year":"2013","unstructured":"Rosenthal RN, Ling W, Casadonte P et al (2013) Buprenorphine implants for treatment of opioid dependence: randomized comparison to placebo and sublingual buprenorphine\/naloxone. Addiction 108:2141\u20132149","journal-title":"Addiction"},{"key":"3785_CR29","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1038\/npp.2010.134","volume":"35","author":"PE Rothwell","year":"2010","unstructured":"Rothwell PE, Gewirtz JC, Thomas MJ (2010) Episodic withdrawal promotes psychomotor sensitization to morphine. Neuropsychopharmacology 35:2579\u20132589","journal-title":"Neuropsychopharmacology"},{"key":"3785_CR30","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/sj.bjp.0706661","volume":"147","author":"Z Saidak","year":"2006","unstructured":"Saidak Z, Blake-Palmer K, Hay DL et al (2006) Differential activation of G-proteins by mu-opioid receptor agonists. Br J Pharmacol 147:671\u2013680","journal-title":"Br J Pharmacol"},{"key":"3785_CR31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1124\/mol.51.1.87","volume":"51","author":"DE Selley","year":"1997","unstructured":"Selley DE, Sim LJ, Xiao R et al (1997) Mu-opioid receptor-stimulated guanosine-5\u2032-O-(gamma-thio)-triphosphate binding in rat thalamus and cultured cell lines: signal transduction mechanisms underlying agonist efficacy. Mol Pharmacol 51:87\u201396","journal-title":"Mol Pharmacol"},{"key":"3785_CR32","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0278-5846(02)00265-8","volume":"26","author":"A Serrano","year":"2002","unstructured":"Serrano A, Aguilar MA, Manzanedo C et al (2002) Effects of DA D1 and D2 antagonists on the sensitisation to the motor effects of morphine in mice. Prog Neuropsychopharmacol Biol Psychiatry 26:1263\u20131271","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3785_CR33","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF02246022","volume":"125","author":"Y Shaham","year":"1996","unstructured":"Shaham Y, Stewart J (1996) Effects of opioid and dopamine receptor antagonists on relapse induced by stress and re-exposure to heroin in rats. Psychopharmacology (Berl) 125:385\u2013391","journal-title":"Psychopharmacology (Berl)"},{"key":"3785_CR34","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0361-9230(03)00077-7","volume":"61","author":"LT Tien","year":"2003","unstructured":"Tien LT, Park Y, Fan LW et al (2003) Increased dopamine D2 receptor binding and enhanced apomorphine-induced locomotor activity in mu-opioid receptor knockout mice. Brain Res Bull 61:109\u2013115","journal-title":"Brain Res Bull"},{"key":"3785_CR35","doi-asserted-by":"crossref","unstructured":"Ting AKR, van der Kooy D (2012) The neurobiology of opiate motivation. Cold Spring Harb Perspect Med 2","DOI":"10.1101\/cshperspect.a012096"},{"key":"3785_CR36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s002130050273","volume":"131","author":"LJ Vanderschuren","year":"1997","unstructured":"Vanderschuren LJ, Tjon GH, Nestby P et al (1997) Morphine-induced long-term sensitization to the locomotor effects of morphine and amphetamine depends on the temporal pattern of the pretreatment regimen. Psychopharmacology (Berl) 131:115\u2013122","journal-title":"Psychopharmacology (Berl)"},{"key":"3785_CR37","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0014-2999(91)90485-9","volume":"195","author":"H Wheeler-Aceto","year":"1991","unstructured":"Wheeler-Aceto H, Cowan A (1991) Buprenorphine and morphine cause antinociception by different transduction mechanisms. Eur J Pharmacol 195:411\u2013413","journal-title":"Eur J Pharmacol"},{"issue":"Suppl 1","key":"3785_CR38","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0091-3057(80)80033-5","volume":"13","author":"RA Wise","year":"1980","unstructured":"Wise RA (1980) Action of drugs of abuse on brain reward systems. Pharmacol Biochem Behav 13(Suppl 1):213\u2013223","journal-title":"Pharmacol Biochem Behav"},{"key":"3785_CR39","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1124\/jpet.104.082560","volume":"313","author":"A Yassen","year":"2005","unstructured":"Yassen A, Olofsen E, Dahan A et al (2005) Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics. J Pharmacol Exp Ther 313:1136\u20131149","journal-title":"J Pharmacol Exp Ther"},{"key":"3785_CR40","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.neuroscience.2006.07.008","volume":"142","author":"JH Yoo","year":"2006","unstructured":"Yoo JH, Yang EM, Cho JH et al (2006) Inhibitory effects of berberine against morphine-induced locomotor sensitization and analgesic tolerance in mice. Neuroscience 142:953\u2013961","journal-title":"Neuroscience"},{"key":"3785_CR41","first-page":"12","volume":"45","author":"S Yu","year":"2006","unstructured":"Yu S, Zhang X, Sun Y et al (2006) Pharmacokinetics of buprenorphine after intravenous administration in the mouse. J Am Assoc Lab Anim Sci 45:12\u201316","journal-title":"J Am Assoc Lab Anim Sci"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-014-3785-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-014-3785-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-014-3785-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T21:22:04Z","timestamp":1746480124000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-014-3785-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,31]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["3785"],"URL":"https:\/\/doi.org\/10.1007\/s00213-014-3785-x","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,31]]}}}