{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:04:37Z","timestamp":1780412677168,"version":"3.54.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"14","license":[{"start":{"date-parts":[[2015,2,21]],"date-time":"2015-02-21T00:00:00Z","timestamp":1424476800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1007\/s00213-015-3884-3","type":"journal-article","created":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T01:46:48Z","timestamp":1424396808000},"page":"2463-2479","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Modafinil and its metabolites enhance the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model"],"prefix":"10.1007","volume":"232","author":[{"given":"Dorota","family":"Zolkowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Andres-Mach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Prisinzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarogniew J.","family":"Luszczki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,2,21]]},"reference":[{"key":"3884_CR1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.yebeh.2012.02.011","volume":"23","author":"E Artsy","year":"2012","unstructured":"Artsy E, McCarthy DC, Hurwitz S, Pavlova MK, Dworetzky BA, Lee JW (2012) Use of modafinil in patients with epilepsy. Epilepsy Behav 23:405\u2013408","journal-title":"Epilepsy Behav"},{"key":"3884_CR2","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/BF00965147","volume":"19","author":"MH Baf","year":"1994","unstructured":"Baf MH, Subhash MN, Lakshmana KM, Rao BS (1994a) Alterations in monoamine levels in discrete regions of rat brain after chronic administration of carbamazepine. Neurochem Res 19:1139\u20131143","journal-title":"Neurochem Res"},{"key":"3884_CR3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0197-0186(94)90130-9","volume":"24","author":"MH Baf","year":"1994","unstructured":"Baf MH, Subhash MN, Lakshmana KM, Rao BS (1994b) Sodium valproate induced alterations in monoamine levels in different regions of the rat brain. Neurochem Int 24:67\u201372","journal-title":"Neurochem Int"},{"key":"3884_CR4","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4088\/JCP.v67n0406","volume":"67","author":"JS Ballon","year":"2006","unstructured":"Ballon JS, Feifel D (2006) A systematic review of modafinil: potential clinical uses and mechanisms of action. J Clin Psychiatry 67:554\u2013566","journal-title":"J Clin Psychiatry"},{"key":"3884_CR5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000134913","volume":"3","author":"JR Boissier","year":"1960","unstructured":"Boissier JR, Tardy J, Diverres JC (1960) Une nouvelle methode simple pour explorer l\u2019action tranquilisante : le test de la cheminee. Med Exp (Basel) 3:81\u201384","journal-title":"Med Exp (Basel)"},{"key":"3884_CR6","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1014233102342","volume":"19","author":"M Cadart","year":"2002","unstructured":"Cadart M, Marchand S, Pariat C, Bouquet S, Couet W (2002) Ignoring pharmacokinetics may lead to isoboles misinterpretation: illustration with the norfloxacin-theophylline convulsant interaction in rats. Pharm Res 19:209\u2013214","journal-title":"Pharm Res"},{"key":"3884_CR7","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1023\/B:NERE.0000029559.20581.1a","volume":"29","author":"N Chatterjie","year":"2004","unstructured":"Chatterjie N, Stables JP, Wang H, Alexander GJ (2004) Anti-narcoleptic agent modafinil and its sulfone: a novel facile synthesis and potential anti-epileptic activity. Neurochem Res 29:1481\u20131486","journal-title":"Neurochem Res"},{"key":"3884_CR8","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.neuropharm.2007.06.017","volume":"53","author":"CR Chen","year":"2007","unstructured":"Chen CR, Qu WM, Qiu MH, Xu XH, Yao MH, Urade Y, Huang ZL (2007) Modafinil exerts a dose-dependent antiepileptic effect mediated by adrenergic alpha1 and histaminergic H1 receptors in mice. Neuropharmacology 53:534\u2013541","journal-title":"Neuropharmacology"},{"key":"3884_CR9","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0090-9556(24)15168-9","volume":"28","author":"L Cuttle","year":"2000","unstructured":"Cuttle L, Munns AJ, Hogg NA, Scott JR, Hooper WD, Dickinson RG, Gillam EM (2000) Phenytoin metabolism by human cytochrome P450: involvement of P450 3A and 2C forms in secondary metabolism and drug-protein adduct formation. Drug Metab Dispos: Biol Fate Chem 28:945\u2013950","journal-title":"Drug Metab Dispos: Biol Fate Chem"},{"key":"3884_CR10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0014-2999(90)90591-S","volume":"180","author":"J Duteil","year":"1990","unstructured":"Duteil J, Rambert FA, Pessonnier J, Hermant JF, Gombert R, Assous E (1990) Central alpha 1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals. Eur J Pharmacol 180:49\u201358","journal-title":"Eur J Pharmacol"},{"key":"3884_CR11","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S0006-3223(97)00353-3","volume":"42","author":"L Ferraro","year":"1997","unstructured":"Ferraro L, Antonelli T, O\u2019Connor WT, Tanganelli S, Rambert FA, Fuxe K (1997) Modafinil: an antinarcoleptic drug with a different neurochemical profile to d-amphetamine and dopamine uptake blockers. Biol Psychiatry 42:1181\u20131183","journal-title":"Biol Psychiatry"},{"key":"3884_CR12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0304-3940(98)00629-6","volume":"253","author":"L Ferraro","year":"1998","unstructured":"Ferraro L, Antonelli T, O\u2019Connor WT, Tanganelli S, Rambert FA, Fuxe K (1998) The effects of modafinil on striatal, pallidal and nigral GABA and glutamate release in the conscious rat: evidence for a preferential inhibition of striato-pallidal GABA transmission. Neurosci Lett 253:135\u2013138","journal-title":"Neurosci Lett"},{"key":"3884_CR13","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S0893-133X(98)00085-2","volume":"20","author":"L Ferraro","year":"1999","unstructured":"Ferraro L, Antonelli T, Tanganelli S, O\u2019Connor WT, Perez de la Mora M, Mendez-Franco J, Rambert FA, Fuxe K (1999) The vigilance promoting drug modafinil increases extracellular glutamate levels in the medial preoptic area and the posterior hypothalamus of the conscious rat: prevention by local GABAA receptor blockade. Neuropsychopharmacol: Off Publ Am Coll Neuropsychopharmacol 20:346\u2013356","journal-title":"Neuropsychopharmacol: Off Publ Am Coll Neuropsychopharmacol"},{"key":"3884_CR14","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/S0028-3908(00)00019-8","volume":"39","author":"L Ferraro","year":"2000","unstructured":"Ferraro L, Fuxe K, Tanganelli S, Fernandez M, Rambert FA, Antonelli T (2000) Amplification of cortical serotonin release: a further neurochemical action of the vigilance-promoting drug modafinil. Neuropharmacology 39:1974\u20131983","journal-title":"Neuropharmacology"},{"key":"3884_CR15","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/sleep\/30.11.1405","volume":"30","author":"E Garcia-Rill","year":"2007","unstructured":"Garcia-Rill E, Heister DS, Ye M, Charlesworth A, Hayar A (2007) Electrical coupling: novel mechanism for sleep-wake control. Sleep 30:1405\u20131414","journal-title":"Sleep"},{"key":"3884_CR16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0304-3940(03)00006-5","volume":"339","author":"T Ishizuka","year":"2003","unstructured":"Ishizuka T, Sakamoto Y, Sakurai T, Yamatodani A (2003) Modafinil increases histamine release in the anterior hypothalamus of rats. Neurosci Lett 339:143\u2013146","journal-title":"Neurosci Lett"},{"key":"3884_CR17","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1528-1157.1998.tb01155.x","volume":"39","author":"SE Krahl","year":"1998","unstructured":"Krahl SE, Clark KB, Smith DC, Browning RA (1998) Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation. Epilepsia 39:709\u2013714","journal-title":"Epilepsia"},{"key":"3884_CR18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-3565(25)03549-9","volume":"96","author":"JT Litchfield Jr","year":"1949","unstructured":"Litchfield JT Jr, Wilcoxon F (1949) A simplified method of evaluating dose-effect experiments. J Pharmacol Exp Ther 96:99\u2013113","journal-title":"J Pharmacol Exp Ther"},{"key":"3884_CR19","first-page":"61","volume":"11","author":"W Loscher","year":"1996","unstructured":"Loscher W, Wauquier A (1996) Use of animal models in developing guiding principles for polypharmacy in epilepsy. Epilepsy Res Suppl 11:61\u201365","journal-title":"Epilepsy Res Suppl"},{"key":"3884_CR20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0920-1211(91)90075-Q","volume":"8","author":"W L\u00f6scher","year":"1991","unstructured":"L\u00f6scher W, Fassbender CP, Nolting B (1991) The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. II. Maximal electroshock seizure models. Epilepsy Res 8:79\u201394","journal-title":"Epilepsy Res"},{"key":"3884_CR21","first-page":"782","volume":"57","author":"JJ Luszczki","year":"2005","unstructured":"Luszczki JJ, Czuczwar SJ (2005) How significant is the difference between drug doses influencing the threshold for electroconvulsions? Pharmacol Rep: PR 57:782\u2013786","journal-title":"Pharmacol Rep: PR"},{"key":"3884_CR22","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.pnpbp.2006.11.020","volume":"31","author":"JJ Luszczki","year":"2007","unstructured":"Luszczki JJ, Czuczwar SJ (2007) Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy. Prog Neuro-Psychopharmacol Biol Psychiatry 31:529\u2013538","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"3884_CR23","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0091-3057(03)00081-9","volume":"75","author":"J Luszczki","year":"2003","unstructured":"Luszczki J, Swiader M, Czuczwar M, Kis J, Czuczwar SJ (2003a) Interactions of tiagabine with some antiepileptics in the maximal electroshock in mice. Pharmacol Biochem Behav 75:319\u2013327","journal-title":"Pharmacol Biochem Behav"},{"key":"3884_CR24","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1038\/sj.npp.1300243","volume":"28","author":"JJ Luszczki","year":"2003","unstructured":"Luszczki JJ, Swiader M, Parada-Turska J, Czuczwar SJ (2003b) Tiagabine synergistically interacts with gabapentin in the electroconvulsive threshold test in mice. Neuropsychopharmacol : Off Publ Am Coll Neuropsychopharmacol 28:1817\u20131830","journal-title":"Neuropsychopharmacol : Off Publ Am Coll Neuropsychopharmacol"},{"key":"3884_CR25","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/sj.npp.1300602","volume":"30","author":"JJ Luszczki","year":"2005","unstructured":"Luszczki JJ, Wojcik-Cwikla J, Andres MM, Czuczwar SJ (2005) Pharmacological and behavioral characteristics of interactions between vigabatrin and conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. Neuropsychopharmacol : Off Publ Am Coll Neuropsychopharmacol 30:958\u2013973","journal-title":"Neuropsychopharmacol : Off Publ Am Coll Neuropsychopharmacol"},{"key":"3884_CR26","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ejphar.2008.11.049","volume":"602","author":"JJ Luszczki","year":"2009","unstructured":"Luszczki JJ, Antkiewicz-Michaluk L, Czuczwar SJ (2009a) Isobolographic analysis of interactions between 1-methyl-1,2,3,4-tetrahydroisoquinoline and four conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model. Eur J Pharmacol 602:298\u2013305","journal-title":"Eur J Pharmacol"},{"key":"3884_CR27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neures.2009.03.010","volume":"64","author":"JJ Luszczki","year":"2009","unstructured":"Luszczki JJ, Kocharov SL, Czuczwar SJ (2009b) N-(anilinomethyl)-p-isopropoxyphenylsuccinimide potentiates the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock-induced seizure model. Neurosci Res 64:267\u2013272","journal-title":"Neurosci Res"},{"key":"3884_CR28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ejphar.2010.08.017","volume":"648","author":"JJ Luszczki","year":"2010","unstructured":"Luszczki JJ, Cioczek JD, Kocharov SL, Andres-Mach M, Kominek M, Zolkowska D (2010a) Effects of three N-(carboxyanilinomethyl) derivatives of p-isopropoxyphenylsuccinimide on the anticonvulsant action of carbamazepine, phenobarbital, phenytoin and valproate in the mouse maximal electroshock-induced seizure model. Eur J Pharmacol 648:74\u201379","journal-title":"Eur J Pharmacol"},{"key":"3884_CR29","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S1734-1140(10)70257-7","volume":"62","author":"JJ Luszczki","year":"2010","unstructured":"Luszczki JJ, Kocharov SL, Czuczwar SJ (2010b) Effect of p-isopropoxyphenylsuccinimide monohydrate on the anticonvulsant action of carbamazepine, phenobarbital, phenytoin and valproate in the mouse maximal electroshock-induced seizure model. Pharmacol Rep: PR 62:194\u2013202","journal-title":"Pharmacol Rep: PR"},{"key":"3884_CR30","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S1734-1140(13)71500-7","volume":"65","author":"JJ Luszczki","year":"2013","unstructured":"Luszczki JJ, Prystupa A, Andres-Mach M, Marzeda E, Florek-Luszczki M (2013) Ivabradine (a hyperpolarization activated cyclic nucleotide-gated channel blocker) elevates the threshold for maximal electroshock-induced tonic seizures in mice. Pharmacol Rep: PR 65:1407\u20131414","journal-title":"Pharmacol Rep: PR"},{"key":"3884_CR31","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/BF00969688","volume":"20","author":"MH Meshkibaf","year":"1995","unstructured":"Meshkibaf MH, Subhash MN, Lakshmana KM, Rao BS (1995) Effect of chronic administration of phenytoin on regional monoamine levels in rat brain. Neurochem Res 20:773\u2013778","journal-title":"Neurochem Res"},{"key":"3884_CR32","first-page":"233","volume":"1","author":"OA Meyer","year":"1979","unstructured":"Meyer OA, Tilson HA, Byrd WC, Riley MT (1979) A method for the routine assessment of fore- and hindlimb grip strength of rats and mice. Neurobehav Toxicol 1:233\u2013236","journal-title":"Neurobehav Toxicol"},{"key":"3884_CR33","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/sj.npp.1301534","volume":"33","author":"MJ Minzenberg","year":"2008","unstructured":"Minzenberg MJ, Carter CS (2008) Modafinil: a review of neurochemical actions and effects on cognition. Neuropsychopharmacol : Off Publ Am Coll Neuropsychopharmacol 33:1477\u20131502","journal-title":"Neuropsychopharmacol : Off Publ Am Coll Neuropsychopharmacol"},{"key":"3884_CR34","volume-title":"Jasper\u2019s basic mechanisms of the epilepsies","author":"JV Nadler","year":"2012","unstructured":"Nadler JV (2012) Plasticity of glutamate synaptic mechanisms. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV (eds) Jasper\u2019s basic mechanisms of the epilepsies. National Center for Biotechnology Information, US"},{"key":"3884_CR35","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.pbb.2010.03.006","volume":"95","author":"NE Paterson","year":"2010","unstructured":"Paterson NE, Fedolak A, Olivier B, Hanania T, Ghavami A, Caldarone B (2010) Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents. Pharmacol Biochem Behav 95:449\u2013456","journal-title":"Pharmacol Biochem Behav"},{"key":"3884_CR36","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1001\/jamainternmed.2013.2807","volume":"173","author":"RA Pe\u00f1aloza","year":"2013","unstructured":"Pe\u00f1aloza RA, Sarkar U, Claman DM, Omachi TA (2013) Trends in on-label and off-label modafinil use in a nationally representative sample. JAMA Intern Med 173:704\u2013706","journal-title":"JAMA Intern Med"},{"key":"3884_CR37","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1034\/j.1601-183X.2002.10205.x","volume":"1","author":"J Podhorna","year":"2002","unstructured":"Podhorna J, Brown RE (2002) Strain differences in activity and emotionality do not account for differences in learning and memory performance between C57BL\/6 and DBA\/2 mice. Genes Brain Behav 1:96\u2013110","journal-title":"Genes Brain Behav"},{"key":"3884_CR38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2165\/00003088-200342020-00002","volume":"42","author":"P Robertson Jr","year":"2003","unstructured":"Robertson P Jr, Hellriegel ET (2003) Clinical pharmacokinetic profile of modafinil. Clin Pharmacokinet 42:123\u2013137","journal-title":"Clin Pharmacokinet"},{"key":"3884_CR39","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0893-133X(99)00072-X","volume":"22","author":"SA Sands","year":"2000","unstructured":"Sands SA, Guerra V, Morilak DA (2000) Changes in tyrosine hydroxylase mRNA expression in the rat locus coeruleus following acute or chronic treatment with valproic acid. Neuropsychopharmacol : Off Publ Am Coll Neuropsychopharmacol 22:27\u201335","journal-title":"Neuropsychopharmacol : Off Publ Am Coll Neuropsychopharmacol"},{"key":"3884_CR40","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1258\/la.2008.008098","volume":"43","author":"H Shang","year":"2009","unstructured":"Shang H, Wei H, Yue B, Xu P, Huang H (2009) Microsatellite analysis in two populations of Kunming mice. Lab Anim 43:34\u201340","journal-title":"Lab Anim"},{"key":"3884_CR41","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0924-977X(95)80011-P","volume":"5","author":"P Simon","year":"1995","unstructured":"Simon P, Hemet C, Ramassamy C, Costentin J (1995) Non-amphetaminic mechanism of stimulant locomotor effect of modafinil in mice. Eur Neuropsychopharmacol 5:509\u2013514","journal-title":"Eur Neuropsychopharmacol"},{"key":"3884_CR42","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4088\/JCP.v67n0120","volume":"67","author":"JM Swanson","year":"2006","unstructured":"Swanson JM, Greenhill LL, Lopez FA, Sedillo A, Earl CQ, Jiang JG, Biederman J (2006) Modafinil film-coated tablets in children and adolescents with attention-deficit\/hyperactivity disorder: results of a randomized, double-blind, placebo-controlled, fixed-dose study followed by abrupt discontinuation. J Clin Psychiatry 67:137\u2013147","journal-title":"J Clin Psychiatry"},{"key":"3884_CR43","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0022-3565(25)05100-6","volume":"106","author":"EA Swinyard","year":"1952","unstructured":"Swinyard EA, Brown WC, Goodman LS (1952) Comparative assays of antiepileptic drugs in mice and rats. J Pharmacol Exp Ther 106:319\u2013330","journal-title":"J Pharmacol Exp Ther"},{"key":"3884_CR44","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0165-3806(01)00213-9","volume":"129","author":"P Szot","year":"2001","unstructured":"Szot P, Weinshenker D, Rho JM, Storey TW, Schwartzkroin PA (2001) Norepinephrine is required for the anticonvulsant effect of the ketogenic diet. Brain Res Dev Brain Res 129:211\u2013214","journal-title":"Brain Res Dev Brain Res"},{"key":"3884_CR45","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/321864a0","volume":"321","author":"P Venault","year":"1986","unstructured":"Venault P, Chapouthier G, de Carvalho LP, Simiand J, Morre M, Dodd RH, Rossier J (1986) Benzodiazepine impairs and beta-carboline enhances performance in learning and memory tasks. Nature 321:864\u2013866","journal-title":"Nature"},{"key":"3884_CR46","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1001\/jama.2009.351","volume":"301","author":"ND Volkow","year":"2009","unstructured":"Volkow ND, Fowler JS, Logan J, Alexoff D, Zhu W, Telang F, Wang GJ, Jayne M, Hooker JM, Wong C, Hubbard B, Carter P, Warner D, King P, Shea C, Xu Y, Muench L, Apelskog-Torres K (2009) Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. JAMA 301:1148\u20131154","journal-title":"JAMA"},{"key":"3884_CR47","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0091-3057(85)90024-3","volume":"23","author":"SB Waller","year":"1985","unstructured":"Waller SB, Buterbaugh GG (1985) Convulsive thresholds and severity and the anticonvulsant effect of phenobarbital and phenytoin in adult rats administered 6-hydroxydopamine or 5,7-dihydroxytryptamine during postnatal development. Pharmacol Biochem Behav 23:473\u2013478","journal-title":"Pharmacol Biochem Behav"},{"key":"3884_CR48","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0163-7258(02)00218-8","volume":"94","author":"D Weinshenker","year":"2002","unstructured":"Weinshenker D, Szot P (2002) The role of catecholamines in seizure susceptibility: new results using genetically engineered mice. Pharmacol Ther 94:213\u2013233","journal-title":"Pharmacol Ther"},{"key":"3884_CR49","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S1734-1140(09)70128-8","volume":"61","author":"A Zadrozniak","year":"2009","unstructured":"Zadrozniak A, Wojda E, Wlaz A, Luszczki JJ (2009) Characterization of acute adverse-effect profiles of selected antiepileptic drugs in the grip-strength test in mice. Pharmacol Rep: PR 61:737\u2013742","journal-title":"Pharmacol Rep: PR"},{"key":"3884_CR50","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1124\/jpet.108.146142","volume":"329","author":"D Zolkowska","year":"2009","unstructured":"Zolkowska D, Jain R, Rothman RB, Partilla JS, Roth BL, Setola V, Prisinzano TE, Baumann MH (2009) Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. J Pharmacol Exp Ther 329:738\u2013746","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-015-3884-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-015-3884-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-015-3884-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T19:50:50Z","timestamp":1747684250000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-015-3884-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,21]]},"references-count":50,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["3884"],"URL":"https:\/\/doi.org\/10.1007\/s00213-015-3884-3","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,21]]}}}