{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:11:20Z","timestamp":1782587480043,"version":"3.54.5"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"18","license":[{"start":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T00:00:00Z","timestamp":1433894400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s00213-015-3979-x","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T17:42:21Z","timestamp":1433958141000},"page":"3319-3325","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Glutamatergic markers, age, intellectual functioning and psychosis in 22q11 deletion syndrome"],"prefix":"10.1007","volume":"232","author":[{"given":"Laurens J. M.","family":"Evers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Therese A. M. J.","family":"van Amelsvoort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap A.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariken","family":"de Koning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Drukker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopold M. G.","family":"Curfs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,10]]},"reference":[{"key":"3979_CR1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/0006-3223(88)90052-2","volume":"23","author":"G Alfredsson","year":"1988","unstructured":"Alfredsson G, Wiesel FA, Tylec A (1988) Relationships between glutamate and monoamine metabolites in cerebrospinal fluid and serum in healthy volunteers. Biol Psychiatry 23:689\u2013697","journal-title":"Biol Psychiatry"},{"key":"3979_CR2","doi-asserted-by":"crossref","unstructured":"Blau N, Duran M, Gibson KM (2008) Laboratory Guide to the Methods in Biochemical Genetics. Springer-Verlag, Berlin, Heidelberg","DOI":"10.1007\/978-3-540-76698-8"},{"key":"3979_CR3","doi-asserted-by":"crossref","first-page":"S33","DOI":"10.1002\/gps.933","volume":"18","author":"S Bleich","year":"2003","unstructured":"Bleich S, Romer K, Wiltfang J, Kornhuber J (2003) Glutamate and the glutamate receptor system: a target for drug action. Int J Geriatr Psychiatry 18:S33\u2013S40","journal-title":"Int J Geriatr Psychiatry"},{"key":"3979_CR4","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1002\/ajmg.a.33665","volume":"152a","author":"J Booij","year":"2010","unstructured":"Booij J, van Amelsvoort T, Boot E (2010) Co-occurrence of early-onset Parkinson disease and 22q11.2 deletion syndrome: potential role for dopamine transporter imaging. Am J Med Genet A 152a:2937\u20132938","journal-title":"Am J Med Genet A"},{"key":"3979_CR5","volume-title":"Response to clozapine in a clinically identifiable subtype of schizophrenia","author":"NJ Butcher","year":"2015","unstructured":"Butcher NJ, Fung WL, Fitzpatrick L, Guna A, Andrade DM, Lang AE, Chow EW, Bassett AS (2015) Response to clozapine in a clinically identifiable subtype of schizophrenia. J Psychiatry, Br"},{"key":"3979_CR6","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1001\/jamaneurol.2013.3646","volume":"70","author":"NJ Butcher","year":"2013","unstructured":"Butcher NJ, Kiehl TR, Hazrati LN, Chow EW, Rogaeva E, Lang AE, Bassett AS (2013) Association between early-onset Parkinson disease and 22q11.2 deletion syndrome: identification of a novel genetic form of Parkinson disease and its clinical implications. JAMA Neurol 70:1359\u20131366","journal-title":"JAMA Neurol"},{"key":"3979_CR7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.ne.11.030188.000425","volume":"11","author":"CW Cotman","year":"1988","unstructured":"Cotman CW, Monaghan DT, Ganong AH (1988) Excitatory amino acid neurotransmission: NMDA receptors and Hebb-type synaptic plasticity. Annu Rev Neurosci 11:61\u201380","journal-title":"Annu Rev Neurosci"},{"key":"3979_CR8","doi-asserted-by":"crossref","first-page":"e21685","DOI":"10.1371\/journal.pone.0021685","volume":"6","author":"F Silva Alves da","year":"2011","unstructured":"da Silva Alves F, Boot E, Schmitz N, Nederveen A, Vorstman J, Lavini C, Pouwels PJ, de Haan L, Linszen D, van Amelsvoort T (2011) Proton magnetic resonance spectroscopy in 22q11 deletion syndrome. PLoS One 6:e21685","journal-title":"PLoS One"},{"key":"3979_CR9","doi-asserted-by":"crossref","unstructured":"De Luca V, Viggiano E, Messina G, Viggiano A, Borlido C, Viggiano A, Monda M (2008) Peripheral amino Acid levels in schizophrenia and antipsychotic treatment. Psychiatry Investig 5(4):203\u2013208","DOI":"10.4306\/pi.2008.5.4.203"},{"key":"3979_CR10","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1016\/j.ridd.2013.06.001","volume":"34","author":"SN Duijff","year":"2013","unstructured":"Duijff SN, Klaassen PW, Swanenburg de Veye HF, Beemer FA, Sinnema G, Vorstman JA (2013) Cognitive and behavioral trajectories in 22q11DS from childhood into adolescence: a prospective 6-year follow-up study. Res Dev Disabil 34:2937\u20132945","journal-title":"Res Dev Disabil"},{"key":"3979_CR11","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1017\/S1461145714000376","volume":"17","author":"LJ Evers","year":"2014","unstructured":"Evers LJ, Curfs LM, Bakker JA, Boot E, da Silva AF, Abeling N, Bierau J, Drukker M, van Amelsvoort TA (2014a) Serotonergic, noradrenergic and dopaminergic markers are related to cognitive function in adults with 22q11 deletion syndrome. Int J Neuropsychopharmacol 17:1159\u20131165","journal-title":"Int J Neuropsychopharmacol"},{"key":"3979_CR12","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/jir.12117","volume":"58","author":"LJ Evers","year":"2014","unstructured":"Evers LJ, van Amelsvoort TA, Candel MJ, Boer H, Engelen JJ, Curfs LM (2014b) Psychopathology in adults with 22q11 deletion syndrome and moderate and severe intellectual disability. J Intellect Disabil Res 58:915\u2013925","journal-title":"J Intellect Disabil Res"},{"key":"3979_CR13","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0006-3223(01)01321-X","volume":"51","author":"DC Goff","year":"2002","unstructured":"Goff DC, Hennen J, Lyoo IK, Tsai G, Wald LL, Evins AE, Yurgelun Todd DA, Renshaw PF (2002) Modulation of brain and serum glutamatergic concentrations following a switch from conventional neuroleptics to olanzapine. Biol Psychiatry 51:493\u2013497","journal-title":"Biol Psychiatry"},{"key":"3979_CR14","doi-asserted-by":"crossref","unstructured":"Goldstein ME, Anderson VM, Pillai A, Kydd RR, Russell BR (2015) Glutamatergic Neurometabolites in Clozapine-Responsive and -Resistant Schizophrenia. Int J Neuropsychopharmacol","DOI":"10.1093\/ijnp\/pyu117"},{"key":"3979_CR15","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1023\/A:1026773005303","volume":"23","author":"BK Goodman","year":"2000","unstructured":"Goodman BK, Rutberg J, Lin WW, Pulver AE, Thomas GH (2000) Hyperprolinaemia in patients with deletion (22)(q11.2) syndrome. J Inherit Metab Dis 23:847\u2013848","journal-title":"J Inherit Metab Dis"},{"key":"3979_CR16","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1002\/jmri.24123","volume":"38","author":"S Hadel","year":"2013","unstructured":"Hadel S, Wirth C, Rapp M, Gallinat J, Schubert F (2013) Effects of age and sex on the concentrations of glutamate and glutamine in the human brain. J Magn Reson Imaging 38:1480\u20131487","journal-title":"J Magn Reson Imaging"},{"key":"3979_CR17","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/mp.2013.92","volume":"18","author":"N Hiroi","year":"2013","unstructured":"Hiroi N, Takahashi T, Hishimoto A, Izumi T, Boku S, Hiramoto T (2013) Copy number variation at 22q11.2: from rare variants to common mechanisms of developmental neuropsychiatric disorders. Mol Psychiatry 18:1153\u20131165","journal-title":"Mol Psychiatry"},{"key":"3979_CR18","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.schres.2007.09.025","volume":"98","author":"ML Hoogendoorn","year":"2008","unstructured":"Hoogendoorn ML, Vorstman JA, Jalali GR, Selten JP, Sinke RJ, Emanuel BS, Kahn RS (2008) Prevalence of 22q11.2 deletions in 311 Dutch patients with schizophrenia. Schizophr Res 98:84\u201388","journal-title":"Schizophr Res"},{"key":"3979_CR19","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/sj.mp.4001597","volume":"10","author":"H Jacquet","year":"2005","unstructured":"Jacquet H, Demily C, Houy E, Hecketsweiler B, Bou J, Raux G, Lerond J, Allio G, Haouzir S, Tillaux A, Bellegou C, Fouldrin G, Delamillieure P, Menard JF, Dollfus S, D\u2019Amato T, Petit M, Thibaut F, Frebourg T, Campion D (2005) Hyperprolinemia is a risk factor for schizoaffective disorder. Mol Psychiatry 10:479\u2013485","journal-title":"Mol Psychiatry"},{"key":"3979_CR20","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1093\/hmg\/11.19.2243","volume":"11","author":"H Jacquet","year":"2002","unstructured":"Jacquet H, Raux G, Thibaut F, Hecketsweiler B, Houy E, Demilly C, Haouzir S, Allio G, Fouldrin G, Drouin V, Bou J, Petit M, Campion D, Frebourg T (2002) PRODH mutations and hyperprolinemia in a subset of schizophrenic patients. Hum Mol Genet 11:2243\u20132249","journal-title":"Hum Mol Genet"},{"key":"3979_CR21","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.neurobiolaging.2004.07.001","volume":"26","author":"LG Kaiser","year":"2005","unstructured":"Kaiser LG, Schuff N, Cashdollar N, Weiner MW (2005) Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T. Neurobiol Aging 26:665\u2013672","journal-title":"Neurobiol Aging"},{"key":"3979_CR22","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1192\/bjp.bp.113.132308","volume":"204","author":"J Kambeitz","year":"2014","unstructured":"Kambeitz J, Abi Dargham A, Kapur S, Howes OD (2014) Alterations in cortical and extrastriatal subcortical dopamine function in schizophrenia: systematic review and meta-analysis of imaging studies. Br J Psychiatry 204:420\u2013429","journal-title":"Br J Psychiatry"},{"key":"3979_CR23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/cercor\/bhn066","volume":"19","author":"TR Kiehl","year":"2009","unstructured":"Kiehl TR, Chow EW, Mikulis DJ, George SR, Bassett AS (2009) Neuropathologic features in adults with 22q11.2 deletion syndrome. Cereb Cortex 19:153\u2013164","journal-title":"Cereb Cortex"},{"key":"3979_CR24","volume-title":"Handboek psychodiagnostiek en beperkte begaafdheid","author":"DW Kraijer","year":"2006","unstructured":"Kraijer DW, Plas JJ (2006) Handboek psychodiagnostiek en beperkte begaafdheid, 4th edn. Harcourt Assesment B.V, Amsterdam","edition":"4"},{"key":"3979_CR25","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00424-010-0809-1","volume":"460","author":"A Lau","year":"2010","unstructured":"Lau A, Tymianski M (2010) Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch 460:525\u2013542","journal-title":"Pflugers Arch"},{"key":"3979_CR26","doi-asserted-by":"crossref","first-page":"e25882","DOI":"10.1371\/journal.pone.0025882","volume":"6","author":"MJ Magnee","year":"2011","unstructured":"Magnee MJ, Lamme VA, de Sain-van der Velden MG, Vorstman JA, Kemner C (2011) Proline and COMT status affect visual connectivity in children with 22q11.2 deletion syndrome. PLoS One 6:e25882","journal-title":"PLoS One"},{"key":"3979_CR27","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.euroneuro.2012.11.003","volume":"23","author":"A Marsman","year":"2013","unstructured":"Marsman A, Mandl RC, van den Heuvel MP, Boer VO, Wijnen JP, Klomp DW, Luijten PR, Hilleke EH (2013) Glutamate changes in healthy young adulthood. Eur Neuropsychopharmacol 23:1484\u20131490","journal-title":"Eur Neuropsychopharmacol"},{"key":"3979_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MD.0b013e3182060469","volume":"90","author":"DM McDonald McGinn","year":"2011","unstructured":"McDonald McGinn DM, Sullivan KE (2011) Chromosome 22q11.2 deletion syndrome (DiGeorge syndrome\/velocardiofacial syndrome). Medicine (Baltimore) 90:1\u201318","journal-title":"Medicine (Baltimore)"},{"key":"3979_CR29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejphar.2012.10.032","volume":"698","author":"A Mehta","year":"2013","unstructured":"Mehta A, Prabhakar M, Kumar P, Deshmukh R, Sharma PL (2013) Excitotoxicity: bridge to various triggers in neurodegenerative disorders. Eur J Pharmacol 698:6\u201318","journal-title":"Eur J Pharmacol"},{"key":"3979_CR30","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0079-6123(08)62693-X","volume":"85","author":"F Mora","year":"1990","unstructured":"Mora F, Cobo M (1990) The neurobiological basis of prefrontal cortex self-stimulation: a review and an integrative hypothesis. Prog Brain Res 85:419\u2013431","journal-title":"Prog Brain Res"},{"key":"3979_CR31","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1055\/s-0031-1295479","volume":"42","author":"T Mori","year":"2011","unstructured":"Mori T, Mori K, Fujii E, Toda Y, Miyazaki M, Harada M, Kagami S (2011) Neuroradiological and neurofunctional examinations for patients with 22q11.2 deletion. Neuropediatrics 42:215\u2013221","journal-title":"Neuropediatrics"},{"key":"3979_CR32","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1001\/archpsyc.56.10.940","volume":"56","author":"KC Murphy","year":"1999","unstructured":"Murphy KC, Jones LA, Owen MJ (1999) High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psychiatry 56:940\u2013945","journal-title":"Arch Gen Psychiatry"},{"key":"3979_CR33","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/nrn916","volume":"3","author":"M Nedergaard","year":"2002","unstructured":"Nedergaard M, Takano T, Hansen AJ (2002) Beyond the role of glutamate as a neurotransmitter. Nat Rev Neurosci 3:748\u2013755","journal-title":"Nat Rev Neurosci"},{"key":"3979_CR34","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.schres.2013.12.013","volume":"152","author":"EM Poels","year":"2014","unstructured":"Poels EM, Kegeles LS, Kantrowitz JT, Javitt DC, Lieberman JA, Abi Dargham A, Girgis RR (2014) Glutamatergic abnormalities in schizophrenia: a review of proton MRS findings. Schizophr Res 152:325\u2013332","journal-title":"Schizophr Res"},{"issue":"Pt 4","key":"3979_CR35","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1046\/j.1365-2788.1998.00146.x","volume":"42","author":"H Prosser","year":"1998","unstructured":"Prosser H, Moss S, Costello H, Simpson N, Patel P, Rowe S (1998) Reliability and validity of the Mini PAS-ADD for assessing psychiatric disorders in adults with intellectual disability. J Intellect Disabil Res 42(Pt 4):264\u2013272","journal-title":"J Intellect Disabil Res"},{"key":"3979_CR36","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/hmg\/ddl443","volume":"16","author":"G Raux","year":"2007","unstructured":"Raux G, Bumsel E, Hecketsweiler B, van Amelsvoort T, Zinkstok J, Manouvrier-Hanu S, Fantini C, Breviere GM, Di Rosa G, Pustorino G, Vogels A, Swillen A, Legallic S, Bou J, Opolczynski G, Drouin-Garraud V, Lemarchand M, Philip N, Gerard-Desplanches A, Carlier M, Philippe A, Nolen MC, Heron D, Sarda P, Lacombe D, Coizet C, Alembik Y, Layet V, Afenjar A, Hannequin D, Demily C, Petit M, Thibaut F, Frebourg T, Campion D (2007) Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome. Hum Mol Genet 16:83\u201391","journal-title":"Hum Mol Genet"},{"key":"3979_CR37","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.mri.2007.06.007","volume":"26","author":"N Sailasuta","year":"2008","unstructured":"Sailasuta N, Ernst T, Chang L (2008) Regional variations and the effects of age and gender on glutamate concentrations in the human brain. Magn Reson Imaging 26:667\u2013675","journal-title":"Magn Reson Imaging"},{"key":"3979_CR38","doi-asserted-by":"crossref","unstructured":"Schneider M, Debbane M, Bassett AS, Chow EW, Fung WL, van den Bree MB, Owen M, Murphy KC, Niarchou M, Kates WR, Antshel KM, Fremont W, McDonald McGinn DM, Gur RE, Zackai EH, Vorstman J, Duijff SN, Klaassen PW, Swillen A, Gothelf D, Green T, Weizman A, Van Amelsvoort T, Evers L, Boot E, Shashi V, Hooper SR, Bearden CE, Jalbrzikowski M, Armando M, Vicari S, Murphy DG, Ousley O, Campbell LE, Simon TJ, Eliez S (2014) Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the international consortium on brain and behavior in 22q11.2 deletion syndrome. Am J Psychiatry 171(6):627\u2013639","DOI":"10.1176\/appi.ajp.2013.13070864"},{"key":"3979_CR39","volume-title":"Vineland Screener 0\u20136 jaar","author":"E Scholte","year":"2008","unstructured":"Scholte E, Duijn VG, Dijkxhoorn Y, Noens I, van Berckelaer-Onnes IA (2008) Vineland Screener 0\u20136 jaar. PITS, Leiden"},{"issue":"Suppl 20","key":"3979_CR40","first-page":"22","volume":"59","author":"DV Sheehan","year":"1998","unstructured":"Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59(Suppl 20):22\u201333, quiz 34\u201357","journal-title":"J Clin Psychiatry"},{"key":"3979_CR41","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1016\/j.neuroimage.2009.10.031","volume":"49","author":"Y Shirayama","year":"2010","unstructured":"Shirayama Y, Obata T, Matsuzawa D, Nonaka H, Kanazawa Y, Yoshitome E, Ikehira H, Hashimoto K, Iyo M (2010) Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: a preliminary study. Neuroimage 49:2783\u20132790","journal-title":"Neuroimage"},{"key":"3979_CR42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000364828","volume":"70","author":"J Song","year":"2014","unstructured":"Song J, Viggiano A, Monda M, De Luca V (2014) Peripheral glutamate levels in schizophrenia: evidence from a meta-analysis. Neuropsychobiology 70:133\u2013141","journal-title":"Neuropsychobiology"},{"key":"3979_CR43","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/sj.mp.4001477","volume":"9","author":"A Sporn","year":"2004","unstructured":"Sporn A, Addington A, Reiss AL, Dean M, Gogtay N, Potocnik U, Greenstein D, Hallmayer J, Gochman P, Lenane M, Baker N, Tossell J, Rapoport JL (2004) 22q11 deletion syndrome in childhood onset schizophrenia: an update. Mol Psychiatry 9:225\u2013226","journal-title":"Mol Psychiatry"},{"key":"3979_CR44","volume-title":"Stata statistical software","author":"StataCorp","year":"2011","unstructured":"StataCorp (2011) Stata statistical software. StataCorparation, Texas"},{"key":"3979_CR45","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1177\/0269881106073126","volume":"21","author":"JM Stone","year":"2007","unstructured":"Stone JM, Morrison PD, Pilowsky LS (2007) Glutamate and dopamine dysregulation in schizophrenia\u2014a synthesis and selective review. J Psychopharmacol 21:440\u2013452","journal-title":"J Psychopharmacol"},{"key":"3979_CR46","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.cca.2007.02.011","volume":"380","author":"M Tomiya","year":"2007","unstructured":"Tomiya M, Fukushima T, Watanabe H, Fukami G, Fujisaki M, Iyo M, Hashimoto K, Mitsuhashi S, Toyo\u2019oka T (2007) Alterations in serum amino acid concentrations in male and female schizophrenic patients. Clin Chim Acta 380:186\u2013190","journal-title":"Clin Chim Acta"},{"key":"3979_CR47","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/npp.2008.132","volume":"34","author":"JA Vorstman","year":"2009","unstructured":"Vorstman JA, Turetsky BI, Sijmens Morcus ME, de Sain MG, Dorland B, Sprong M, Rappaport EF, Beemer FA, Emanuel BS, Kahn RS, van Engeland H, Kemner C (2009) Proline affects brain function in 22q11DS children with the low activity COMT 158 allele. Neuropsychopharmacology 34:739\u2013746","journal-title":"Neuropsychopharmacology"},{"key":"3979_CR48","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1471-244X-14-102","volume":"14","author":"S Warnez","year":"2014","unstructured":"Warnez S, Alessi Severini S (2014) Clozapine: a review of clinical practice guidelines and prescribing trends. BMC Psychiatry 14:102","journal-title":"BMC Psychiatry"},{"key":"3979_CR49","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cca.2009.06.023","volume":"407","author":"WA Waterval","year":"2009","unstructured":"Waterval WA, Scheijen JL, Ortmans Ploemen MM, Habets van der Poel CD, Bierau J (2009) Quantitative UPLC-MS\/MS analysis of underivatised amino acids in body fluids is a reliable tool for the diagnosis and follow-up of patients with inborn errors of metabolism. Clin Chim Acta 407:36\u201342","journal-title":"Clin Chim Acta"},{"key":"3979_CR50","volume-title":"Wechsler adult intelligence scale third edition","author":"D Wechsler","year":"1997","unstructured":"Wechsler D (1997) Wechsler adult intelligence scale third edition. The Psychological Corporation, San Antonio"},{"key":"3979_CR51","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ajmg.b.20168","volume":"129B","author":"GJ Wiehahn","year":"2004","unstructured":"Wiehahn GJ, Bosch GP, du Preez RR, Pretorius HW, Karayiorgou M, Roos JL (2004) Assessment of the frequency of the 22q11 deletion in Afrikaner schizophrenic patients. Am J Med Genet B Neuropsychiatr Genet 129B:20\u201322","journal-title":"Am J Med Genet B Neuropsychiatr Genet"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-015-3979-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-015-3979-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-015-3979-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T12:06:59Z","timestamp":1717934819000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-015-3979-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,10]]},"references-count":51,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["3979"],"URL":"https:\/\/doi.org\/10.1007\/s00213-015-3979-x","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,10]]}}}