{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:16:12Z","timestamp":1786979772606,"version":"build-2736575974"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"18","license":[{"start":{"date-parts":[[2015,7,5]],"date-time":"2015-07-05T00:00:00Z","timestamp":1436054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1007\/s00213-015-4000-4","type":"journal-article","created":{"date-parts":[[2015,7,3]],"date-time":"2015-07-03T19:53:44Z","timestamp":1435953224000},"page":"3455-3467","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Modeling bipolar disorder in mice by increasing acetylcholine or dopamine: chronic lithium treats most, but not all features"],"prefix":"10.1007","volume":"232","author":[{"given":"Jordy","family":"van Enkhuizen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgane","family":"Milienne-Petiot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Geyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared W.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,7,5]]},"reference":[{"key":"4000_CR1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.biopsych.2011.01.018","volume":"70","author":"M Adida","year":"2011","unstructured":"Adida M, Jollant F, Clark L, Besnier N, Guillaume S, Kaladjian A, Mazzola-Pomietto P, Jeanningros R, Goodwin GM, Azorin JM, Courtet P (2011) Trait-related decision-making impairment in the three phases of bipolar disorder. Biol Psychiatry 70:357\u201365","journal-title":"Biol Psychiatry"},{"key":"4000_CR2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1399-5618.2011.00936.x","volume":"13","author":"A Anand","year":"2011","unstructured":"Anand A, Barkay G, Dzemidzic M, Albrecht D, Karne H, Zheng QH, Hutchins GD, Normandin MD, Yoder KK (2011) Striatal dopamine transporter availability in unmedicated bipolar disorder. Bipolar Disord 13:406\u201313","journal-title":"Bipolar Disord"},{"key":"4000_CR3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.cell.2007.11.041","volume":"132","author":"JM Beaulieu","year":"2008","unstructured":"Beaulieu JM, Marion S, Rodriguiz RM, Medvedev IO, Sotnikova TD, Ghisi V, Wetsel WC, Lefkowitz RJ, Gainetdinov RR, Caron MG (2008) A beta-arrestin 2 signaling complex mediates lithium action on behavior. Cell 132:125\u201336","journal-title":"Cell"},{"key":"4000_CR4","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2165\/00019053-200119050-00004","volume":"19","author":"CE Begley","year":"2001","unstructured":"Begley CE, Annegers JF, Swann AC, Lewis C, Coan S, Schnapp WB, Bryant-Comstock L (2001) The lifetime cost of bipolar disorder in the US: an estimate for new cases in 1998. Pharmacoeconomics 19:483\u201395","journal-title":"Pharmacoeconomics"},{"key":"4000_CR5","first-page":"239","volume":"4","author":"RH Belmaker","year":"2004","unstructured":"Belmaker RH, Bersudsky Y (2004) Bipolar disorder: mania and depression. Discov Med 4:239\u201345","journal-title":"Discov Med"},{"key":"4000_CR6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF01256470","volume":"64","author":"U Berggren","year":"1985","unstructured":"Berggren U (1985) Effects of chronic lithium treatment on brain monoamine metabolism and amphetamine-induced locomotor stimulation in rats. J Neural Transm 64:239\u201350","journal-title":"J Neural Transm"},{"key":"4000_CR7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/FBP.0b013e32801416ed","volume":"18","author":"Y Bersudsky","year":"2007","unstructured":"Bersudsky Y, Shaldubina A, Belmaker RH (2007) Lithium\u2019s effect in forced-swim test is blood level dependent but not dependent on weight loss. Behav Pharmacol 18:77\u201380","journal-title":"Behav Pharmacol"},{"key":"4000_CR8","unstructured":"Brambilla P, Perlini C, Bellani M, Tomelleri L, Ferro A, Cerruti S, Marinelli V, Rambaldelli G, Christodoulou T, Jogia J, Dima D, Tansella M, Balestrieri M, Frangou S (2012) Increased salience of gains versus decreased associative learning differentiate bipolar disorder from schizophrenia during incentive decision making. Psychological Medicine: 1\u201310"},{"key":"4000_CR9","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1601-183X.2011.00682.x","volume":"10","author":"A Can","year":"2011","unstructured":"Can A, Blackwell RA, Piantadosi SC, Dao DT, O'Donnell KC, Gould TD (2011) Antidepressant-like responses to lithium in genetically diverse mouse strains. Genes Brain Behav 10:434\u201343","journal-title":"Genes Brain Behav"},{"key":"4000_CR10","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/S0140-6736(11)60873-8","volume":"378","author":"A Cipriani","year":"2011","unstructured":"Cipriani A, Barbui C, Salanti G, Rendell J, Brown R, Stockton S, Purgato M, Spineli LM, Goodwin GM, Geddes JR (2011) Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis. Lancet 378:1306\u201315","journal-title":"Lancet"},{"key":"4000_CR11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.pbb.2005.04.006","volume":"81","author":"MG Clark","year":"2005","unstructured":"Clark MG, Sun W, Myers TM, Bansal R, Doctor BP, Saxena A (2005) Effects of physostigmine and human butyrylcholinesterase on acoustic startle reflex and prepulse inhibition in C57BL\/6J mice. Pharmacol Biochem Behav 81:497\u2013505","journal-title":"Pharmacol Biochem Behav"},{"key":"4000_CR12","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","volume":"29","author":"JF Cryan","year":"2005","unstructured":"Cryan JF, Mombereau C, Vassout A (2005) The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci Biobehav Rev 29:571\u2013625","journal-title":"Neurosci Biobehav Rev"},{"key":"4000_CR13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0028-3908(94)00121-8","volume":"34","author":"AR Dehpour","year":"1995","unstructured":"Dehpour AR, Farsam H, Azizabadi-Farahani M (1995) Inhibition of the morphine withdrawal syndrome and the development of physical dependence by lithium in mice. Neuropharmacology 34:115\u201321","journal-title":"Neuropharmacology"},{"key":"4000_CR14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1034\/j.1600-0773.2002.900206.x","volume":"90","author":"AR Dehpour","year":"2002","unstructured":"Dehpour AR, Sadr SS, Azizi MR, Namiranian K, Farahani M, Javidan AN (2002) Lithium inhibits the development of physical dependence to clonidine in mice. Pharmacol Toxicol 90:89\u201393","journal-title":"Pharmacol Toxicol"},{"key":"4000_CR15","unstructured":"DSM-V (2013) Diagnostic and statistical manual of mental health disorders: DSM-5 (5th ed.). American Psychiatric Publishing, American Psychiatric Publishing"},{"key":"4000_CR16","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1126\/science.1234152","volume":"340","author":"D Dulcis","year":"2013","unstructured":"Dulcis D, Jamshidi P, Leutgeb S, Spitzer NC (2013) Neurotransmitter switching in the adult brain regulates behavior. Science 340:449\u201353","journal-title":"Science"},{"key":"4000_CR17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF01300132","volume":"40","author":"R Dunstan","year":"1977","unstructured":"Dunstan R, Jackson DM (1977) The demonstration of a change in responsiveness of mice to physostigmine and atropine after withdrawal from long-term haloperidol pretreatment. J Neural Transm 40:181\u20139","journal-title":"J Neural Transm"},{"key":"4000_CR18","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1360-0443.1973.tb01264.x","volume":"68","author":"MK El-Yousef","year":"1973","unstructured":"El-Yousef MK, Janowsky DS, Davis JM, Rosenblatt JE (1973) Induction of severe depression by physostigmine in marihuana intoxicated individuals. Br J Addic Alcohol Other Drugs 68:321\u20135","journal-title":"Br J Addic Alcohol Other Drugs"},{"key":"4000_CR19","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.bbr.2012.10.051","volume":"243","author":"S Esumi","year":"2013","unstructured":"Esumi S, Sagara H, Nakamoto A, Kawasaki Y, Gomita Y, Sendo T (2013) Effect of GBR12909 on affective behavior: distinguishing motivational behavior from antidepressant-like and addiction-like behavior using the runway model of intracranial self-stimulation. Behav Brain Res 243:313\u201321","journal-title":"Behav Brain Res"},{"key":"4000_CR20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ejphar.2012.02.048","volume":"683","author":"PR Gard","year":"2012","unstructured":"Gard PR, Naylor C, Ali S, Partington C (2012) Blockade of pro-cognitive effects of angiotensin IV and physostigmine in mice by oxytocin antagonism. Eur J Pharmacol 683:155\u201360","journal-title":"Eur J Pharmacol"},{"key":"4000_CR21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1176\/appi.ajp.161.2.217","volume":"161","author":"JR Geddes","year":"2004","unstructured":"Geddes JR, Burgess S, Hawton K, Jamison K, Goodwin GM (2004) Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials. Am J Psychiatr 161:217\u201322","journal-title":"Am J Psychiatr"},{"key":"4000_CR22","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/sj.mp.4001159","volume":"7","author":"MA Geyer","year":"2002","unstructured":"Geyer MA, McIlwain KL, Paylor R (2002) Mouse genetic models for prepulse inhibition: an early review. Mol Psychiatry 7:1039\u201353","journal-title":"Mol Psychiatry"},{"key":"4000_CR23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0091-3057(86)90266-2","volume":"25","author":"MA Geyer","year":"1986","unstructured":"Geyer MA, Russo PV, Masten VL (1986) Multivariate assessment of locomotor behavior: pharmacological and behavioral analyses. Pharmacol Biochem Behav 25:277\u201388","journal-title":"Pharmacol Biochem Behav"},{"key":"4000_CR24","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbr.2008.12.032","volume":"200","author":"M Ghasemi","year":"2009","unstructured":"Ghasemi M, Sadeghipour H, Poorheidari G, Dehpour AR (2009) A role for nitrergic system in the antidepressant-like effects of chronic lithium treatment in the mouse forced swimming test. Behav Brain Res 200:76\u201382","journal-title":"Behav Brain Res"},{"key":"4000_CR25","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/sj.npp.1301254","volume":"32","author":"TD Gould","year":"2007","unstructured":"Gould TD, O'Donnell KC, Picchini AM, Manji HK (2007) Strain differences in lithium attenuation of d-amphetamine-induced hyperlocomotion: a mouse model for the genetics of clinical response to lithium. Neuropsychopharmacology 32:1321\u201333","journal-title":"Neuropsychopharmacology"},{"key":"4000_CR26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0166-4328(00)00318-1","volume":"118","author":"TJ Gould","year":"2001","unstructured":"Gould TJ, Keith RA, Bhat RV (2001) Differential sensitivity to lithium's reversal of amphetamine-induced open-field activity in two inbred strains of mice. Behav Brain Res 118:95\u2013105","journal-title":"Behav Brain Res"},{"issue":"Suppl 9","key":"4000_CR27","first-page":"3","volume":"67","author":"MF Green","year":"2006","unstructured":"Green MF (2006) Cognitive impairment and functional outcome in schizophrenia and bipolar disorder. J Clin Psychiatry 67(Suppl 9):3\u20138, discussion 36\u201342","journal-title":"J Clin Psychiatry"},{"key":"4000_CR28","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.biopsych.2013.04.004","volume":"74","author":"JO Hannestad","year":"2013","unstructured":"Hannestad JO, Cosgrove KP, DellaGioia NF, Perkins E, Bois F, Bhagwagar Z, Seibyl JP, McClure-Begley TD, Picciotto MR, Esterlis I (2013) Changes in the cholinergic system between bipolar depression and euthymia as measured with [123I]5IA single photon emission computed tomography. Biol Psychiatry 74:768\u201376","journal-title":"Biol Psychiatry"},{"key":"4000_CR29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0006-3223(91)90041-J","volume":"29","author":"G Hasey","year":"1991","unstructured":"Hasey G, Hanin I (1991) The cholinergic-adrenergic hypothesis of depression reexamined using clonidine, metoprolol, and physostigmine in an animal model. Biol Psychiatry 29:127\u201338","journal-title":"Biol Psychiatry"},{"key":"4000_CR30","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.jad.2013.05.020","volume":"150","author":"BL Henry","year":"2013","unstructured":"Henry BL, Minassian A, Patt VM, Hua J, Young JW, Geyer MA, Perry W (2013) Inhibitory deficits in euthymic bipolar disorder patients assessed in the human behavioral pattern monitor. J Affect Disord 150:948\u201354","journal-title":"J Affect Disord"},{"key":"4000_CR31","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.neubiorev.2010.04.002","volume":"34","author":"BL Henry","year":"2010","unstructured":"Henry BL, Minassian A, Young JW, Paulus MP, Geyer MA, Perry W (2010) Cross-species assessments of motor and exploratory behavior related to bipolar disorder. Neurosci Biobehav Rev 34:1296\u2013306","journal-title":"Neurosci Biobehav Rev"},{"key":"4000_CR32","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00006842-197405000-00008","volume":"36","author":"DS Janowsky","year":"1974","unstructured":"Janowsky DS, el-Yousef MK, Davis JM (1974) Acetylcholine and depression. Psychosom Med 36:248\u201357","journal-title":"Psychosom Med"},{"key":"4000_CR33","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0140-6736(72)93021-8","volume":"2","author":"DS Janowsky","year":"1972","unstructured":"Janowsky DS, el-Yousef MK, Davis JM, Sekerke HJ (1972) A cholinergic-adrenergic hypothesis of mania and depression. Lancet 2:632\u20135","journal-title":"Lancet"},{"key":"4000_CR34","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1471-4159.1979.tb05179.x","volume":"33","author":"R Jope","year":"1979","unstructured":"Jope R (1979) Effects of lithium treatment in vitro and in vivo on acetylcholine metabolism in rat brain. J Neurochem 33:487\u201395","journal-title":"J Neurochem"},{"key":"4000_CR35","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/0014-4886(86)90200-1","volume":"93","author":"RS Jope","year":"1986","unstructured":"Jope RS, Morrisett RA (1986) Neurochemical consequences of status epilepticus induced in rats by coadministration of lithium and pilocarpine. Exp Neurol 93:404\u201314","journal-title":"Exp Neurol"},{"key":"4000_CR36","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jpsychires.2012.11.018","volume":"47","author":"S Kohl","year":"2013","unstructured":"Kohl S, Heekeren K, Klosterkotter J, Kuhn J (2013) Prepulse inhibition in psychiatric disorders\u2014apart from schizophrenia. J Psychiatr Res 47:445\u201352","journal-title":"J Psychiatr Res"},{"key":"4000_CR37","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejphar.2012.11.041","volume":"699","author":"P Kwek","year":"2013","unstructured":"Kwek P, van den Buuse M (2013) Modafinil disrupts prepulse inhibition in mice: strain differences and involvement of dopaminergic and serotonergic activation. Eur J Pharmacol 699:132\u201340","journal-title":"Eur J Pharmacol"},{"key":"4000_CR38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0006-3223(85)90132-5","volume":"20","author":"B Lerer","year":"1985","unstructured":"Lerer B (1985) Studies on the role of brain cholinergic systems in the therapeutic mechanisms and adverse effects of ECT and lithium. Biol Psychiatry 20:20\u201340","journal-title":"Biol Psychiatry"},{"key":"4000_CR39","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.bbr.2010.05.027","volume":"214","author":"M Loos","year":"2010","unstructured":"Loos M, Staal J, Schoffelmeer AN, Smit AB, Spijker S, Pattij T (2010) Inhibitory control and response latency differences between C57BL\/6J and DBA\/2J mice in a Go\/No-Go and 5-choice serial reaction time task and strain-specific responsivity to amphetamine. Behav Brain Res 214:216\u201324","journal-title":"Behav Brain Res"},{"key":"4000_CR40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.pnpbp.2003.10.015","volume":"28","author":"R Machado-Vieira","year":"2004","unstructured":"Machado-Vieira R, Kapczinski F, Soares JC (2004) Perspectives for the development of animal models of bipolar disorder. Prog Neuro-Psychopharmacol Biol Psychiatry 28:209\u201324","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"4000_CR41","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/0004867412437346","volume":"46","author":"GS Malhi","year":"2012","unstructured":"Malhi GS, Tanious M, Das P, Berk M (2012) The science and practice of lithium therapy. Aust N Z J Psychiatry 46:192\u2013211","journal-title":"Aust N Z J Psychiatry"},{"key":"4000_CR42","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1242\/dmm.001628","volume":"2","author":"O Malkesman","year":"2009","unstructured":"Malkesman O, Austin DR, Chen G, Manji HK (2009) Reverse translational strategies for developing animal models of bipolar disorder. Dis Model Mech 2:238\u201345","journal-title":"Dis Model Mech"},{"key":"4000_CR43","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archgenpsychiatry.2011.12","volume":"68","author":"KR Merikangas","year":"2011","unstructured":"Merikangas KR, Jin R, He JP, Kessler RC, Lee S, Sampson NA, Viana MC, Andrade LH, Hu C, Karam EG, Ladea M, Medina-Mora ME, Ono Y, Posada-Villa J, Sagar R, Wells JE, Zarkov Z (2011) Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch Gen Psychiatry 68:241\u201351","journal-title":"Arch Gen Psychiatry"},{"key":"4000_CR44","volume":"6","author":"A Minassian","year":"2011","unstructured":"Minassian A, Henry BL, Young JW, Masten V, Geyer MA, Perry W (2011) Repeated assessment of exploration and novelty seeking in the human behavioral pattern monitor in bipolar disorder patients and healthy individuals. Public Library of Science One 6, e24185","journal-title":"Public Library of Science One"},{"key":"4000_CR45","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1073\/pnas.1219731110","volume":"110","author":"YS Mineur","year":"2013","unstructured":"Mineur YS, Obayemi A, Wigestrand MB, Fote GM, Calarco CA, Li AM, Picciotto MR (2013) Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior. Proc Natl Acad Sci U S A 110:3573\u20138","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4000_CR46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-5618.2009.00786.x","volume":"12","author":"DM Novick","year":"2010","unstructured":"Novick DM, Swartz HA, Frank E (2010) Suicide attempts in bipolar I and bipolar II disorder: a review and meta-analysis of the evidence. Bipolar Disord 12:1\u20139","journal-title":"Bipolar Disord"},{"key":"4000_CR47","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1001\/archpsyc.58.9.844","volume":"58","author":"U Osby","year":"2001","unstructured":"Osby U, Brandt L, Correia N, Ekbom A, Sparen P (2001) Excess mortality in bipolar and unipolar disorder in Sweden. Arch Gen Psychiatry 58:844\u201350","journal-title":"Arch Gen Psychiatry"},{"key":"4000_CR48","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0149-7634(05)80230-1","volume":"17","author":"DH Overstreet","year":"1993","unstructured":"Overstreet DH (1993) The Flinders sensitive line rats: a genetic animal model of depression. Neurosci Biobehav Rev 17:51\u201368","journal-title":"Neurosci Biobehav Rev"},{"key":"4000_CR49","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/BF02244547","volume":"104","author":"MP Paulus","year":"1991","unstructured":"Paulus MP, Geyer MA (1991) A temporal and spatial scaling hypothesis for the behavioral effects of psychostimulants. Psychopharmacology (Berl) 104:6\u201316","journal-title":"Psychopharmacology (Berl)"},{"key":"4000_CR50","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0165-0327(03)00157-5","volume":"81","author":"W Perry","year":"2004","unstructured":"Perry W, Minassian A, Feifel D (2004) Prepulse inhibition in patients with non-psychotic major depressive disorder. J Affect Disord 81:179\u201384","journal-title":"J Affect Disord"},{"key":"4000_CR51","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0006-3223(01)01184-2","volume":"50","author":"W Perry","year":"2001","unstructured":"Perry W, Minassian A, Feifel D, Braff DL (2001) Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania. Biol Psychiatry 50:418\u201324","journal-title":"Biol Psychiatry"},{"key":"4000_CR52","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.psychres.2010.04.032","volume":"178","author":"W Perry","year":"2010","unstructured":"Perry W, Minassian A, Henry B, Kincaid M, Young JW, Geyer MA (2010) Quantifying over-activity in bipolar and schizophrenia patients in a human open field paradigm. Psychiatry Res 178:84\u201391","journal-title":"Psychiatry Res"},{"key":"4000_CR53","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1001\/archgenpsychiatry.2009.58","volume":"66","author":"W Perry","year":"2009","unstructured":"Perry W, Minassian A, Paulus MP, Young JW, Kincaid MJ, Ferguson EJ, Henry BL, Zhuang X, Masten VL, Sharp RF, Geyer MA (2009) A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men. Arch Gen Psychiatry 66:1072\u201380","journal-title":"Arch Gen Psychiatry"},{"key":"4000_CR54","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00213-004-2048-7","volume":"177","author":"B Petit-Demouliere","year":"2005","unstructured":"Petit-Demouliere B, Chenu F, Bourin M (2005) Forced swimming test in mice: a review of antidepressant activity. Psychopharmacology 177:245\u201355","journal-title":"Psychopharmacology"},{"key":"4000_CR55","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jad.2006.01.022","volume":"92","author":"BB Quednow","year":"2006","unstructured":"Quednow BB, Westheide J, Kuhn KU, Werner P, Maier W, Hawellek B, Wagner M (2006) Normal prepulse inhibition and habituation of acoustic startle response in suicidal depressive patients without psychotic symptoms. J Affect Disord 92:299\u2013303","journal-title":"J Affect Disord"},{"key":"4000_CR56","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jad.2011.08.017","volume":"136","author":"JS Rao","year":"2012","unstructured":"Rao JS, Kellom M, Reese EA, Rapoport SI, Kim HW (2012) Dysregulated glutamate and dopamine transporters in postmortem frontal cortex from bipolar and schizophrenic patients. J Affect Disord 136:63\u201371","journal-title":"J Affect Disord"},{"key":"4000_CR57","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1038\/sj.npp.1301161","volume":"31","author":"VB Risbrough","year":"2006","unstructured":"Risbrough VB, Masten VL, Caldwell S, Paulus MP, Low MJ, Geyer MA (2006) Differential contributions of dopamine D1, D2, and D3 receptors to MDMA-induced effects on locomotor behavior patterns in mice. Neuropsychopharmacology 31:2349\u201358","journal-title":"Neuropsychopharmacology"},{"key":"4000_CR58","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0165-1781(81)90012-3","volume":"4","author":"SC Risch","year":"1981","unstructured":"Risch SC, Cohen RM, Janowsky DS, Kalin NH, Sitaram N, Gillin JC, Murphy DL (1981) Physostigmine induction of depressive symptomatology in normal human subjects. Psychiatry Res 4:89\u201394","journal-title":"Psychiatry Res"},{"key":"4000_CR59","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.1073\/pnas.0609625104","volume":"104","author":"K Roybal","year":"2007","unstructured":"Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA Jr, McClung CA (2007) Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A 104:6406\u201311","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4000_CR60","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1176\/appi.ajp.2012.11101546","volume":"169","author":"A Saricicek","year":"2012","unstructured":"Saricicek A, Esterlis I, Maloney KH, Mineur YS, Ruf BM, Muralidharan A, Chen JI, Cosgrove KP, Kerestes R, Ghose S, Tamminga CA, Pittman B, Bois F, Tamagnan G, Seibyl J, Picciotto MR, Staley JK, Bhagwagar Z (2012) Persistent beta2*-nicotinic acetylcholinergic receptor dysfunction in major depressive disorder. Am J Psychiatr 169:851\u20139","journal-title":"Am J Psychiatr"},{"key":"4000_CR61","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbr.2010.01.022","volume":"209","author":"G Sarkisyan","year":"2010","unstructured":"Sarkisyan G, Roberts AJ, Hedlund PB (2010) The 5-HT(7) receptor as a mediator and modulator of antidepressant-like behavior. Behav Brain Res 209:99\u2013108","journal-title":"Behav Brain Res"},{"key":"4000_CR62","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s007020200035","volume":"109","author":"A Shaldubina","year":"2002","unstructured":"Shaldubina A, Einat H, Szechtman H, Shimon H, Belmaker RH (2002) Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder. J Neural Transm 109:433\u201340","journal-title":"J Neural Transm"},{"key":"4000_CR63","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.mehy.2011.10.005","volume":"78","author":"JA Sherman","year":"2012","unstructured":"Sherman JA (2012) Evolutionary origin of bipolar disorder-revised: EOBD-R. Med Hypotheses 78:113\u201322","journal-title":"Med Hypotheses"},{"key":"4000_CR64","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbr.2012.04.045","volume":"233","author":"S Tanaka","year":"2012","unstructured":"Tanaka S, Young JW, Halberstadt AL, Masten VL, Geyer MA (2012) Four factors underlying mouse behavior in an open field. Behav Brain Res 233:55\u201361","journal-title":"Behav Brain Res"},{"key":"4000_CR65","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1017\/S1461145712001198","volume":"16","author":"J Enkhuizen van","year":"2013","unstructured":"van Enkhuizen J, Geyer MA, Kooistra K, Young JW (2013a) Chronic valproate attenuates some, but not all, facets of mania-like behaviour in mice. Int J Neuropsychopharmacol 16:1021\u201331","journal-title":"Int J Neuropsychopharmacol"},{"key":"4000_CR66","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00213-012-2854-2","volume":"225","author":"J Enkhuizen van","year":"2013","unstructured":"van Enkhuizen J, Geyer MA, Young JW (2013b) Differential effects of dopamine transporter inhibitors in the rodent Iowa gambling task : relevance to mania. Psychopharmacology 225:661\u201374","journal-title":"Psychopharmacology"},{"key":"4000_CR67","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1038\/npp.2014.170","volume":"39","author":"J Enkhuizen van","year":"2014","unstructured":"van Enkhuizen J, Henry BL, Minassian A, Perry W, Milienne-Petiot M, Higa KK, Geyer MA, Young JW (2014a) Reduced dopamine transporter functioning induces high-reward risk-preference consistent with bipolar disorder. Neuropsychopharmacology 39:3112\u201322","journal-title":"Neuropsychopharmacology"},{"key":"4000_CR68","doi-asserted-by":"crossref","unstructured":"van Enkhuizen J, Janowsky DS, Olivier B, Minassian A, Perry W, Young JW, Geyer MA (2014b) The catecholaminergic-cholinergic balance hypothesis of bipolar disorder revisited. Eur J Pharmacol","DOI":"10.1016\/j.ejphar.2014.05.063"},{"key":"4000_CR69","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ejphar.2014.05.063","volume":"753","author":"J Enkhuizen van","year":"2015","unstructured":"van Enkhuizen J, Janowsky DS, Olivier B, Minassian A, Perry W, Young JW, Geyer MA (2015) The catecholaminergic-cholinergic balance hypothesis of bipolar disorder revisited. Eur J Pharmacol 753:114\u201326","journal-title":"Eur J Pharmacol"},{"key":"4000_CR70","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbr.2013.04.023","volume":"249","author":"J Enkhuizen van","year":"2013","unstructured":"van Enkhuizen J, Minassian A, Young JW (2013c) Further evidence for ClockDelta19 mice as a model for bipolar disorder mania using cross-species tests of exploration and sensorimotor gating. Behav Brain Res 249:44\u201354","journal-title":"Behav Brain Res"},{"key":"4000_CR71","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.psychres.2012.11.021","volume":"209","author":"RB Varela","year":"2013","unstructured":"Varela RB, Valvassori SS, Lopes-Borges J, Fraga DB, Resende WR, Arent CO, Zugno AI, Quevedo J (2013) Evaluation of acetylcholinesterase in an animal model of mania induced by D-amphetamine. Psychiatry Res 209:229\u201334","journal-title":"Psychiatry Res"},{"key":"4000_CR72","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejphar.2015.03.019","volume":"759","author":"JW Young","year":"2015","unstructured":"Young JW, Dulcis D (2015) Investigating the mechanism(s) underlying switching between states in bipolar disorder. Eur J Pharmacol 759:151\u2013162","journal-title":"Eur J Pharmacol"},{"key":"4000_CR73","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.biopsych.2009.12.015","volume":"67","author":"JW Young","year":"2010","unstructured":"Young JW, Geyer MA (2010) Action of modafinil\u2014increased motivation via the dopamine transporter inhibition and D1 receptors? Biol Psychiatry 67:784\u20137","journal-title":"Biol Psychiatry"},{"key":"4000_CR74","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00213-009-1744-8","volume":"208","author":"JW Young","year":"2010","unstructured":"Young JW, Goey AK, Minassian A, Perry W, Paulus MP, Geyer MA (2010a) GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior. Psychopharmacology (Berlin) 208:443\u201354","journal-title":"Psychopharmacology (Berlin)"},{"key":"4000_CR75","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.pbb.2010.03.014","volume":"96","author":"JW Young","year":"2010","unstructured":"Young JW, Goey AK, Minassian A, Perry W, Paulus MP, Geyer MA (2010b) The mania-like exploratory profile in genetic dopamine transporter mouse models is diminished in a familiar environment and reinstated by subthreshold psychostimulant administration. Pharmacol Biochem Behav 96:7\u201315","journal-title":"Pharmacol Biochem Behav"},{"key":"4000_CR76","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1111\/j.1476-5381.2011.01318.x","volume":"164","author":"JW Young","year":"2011","unstructured":"Young JW, Henry BL, Geyer MA (2011a) Predictive animal models of mania: hits, misses and future directions. Br J Pharmacol 164:1263\u201384","journal-title":"Br J Pharmacol"},{"key":"4000_CR77","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1177\/0269881111400646","volume":"25","author":"JW Young","year":"2011","unstructured":"Young JW, van Enkhuizen J, Winstanley CA, Geyer MA (2011b) Increased risk-taking behavior in dopamine transporter knockdown mice: further support for a mouse model of mania. J Psychopharmacol 25:934\u201343","journal-title":"J Psychopharmacol"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-015-4000-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-015-4000-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-015-4000-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T19:50:07Z","timestamp":1566935407000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-015-4000-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,5]]},"references-count":77,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["4000"],"URL":"https:\/\/doi.org\/10.1007\/s00213-015-4000-4","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,5]]}}}