{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:04:02Z","timestamp":1789023842882,"version":"build-2803163510"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"19","license":[{"start":{"date-parts":[[2015,8,2]],"date-time":"2015-08-02T00:00:00Z","timestamp":1438473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1007\/s00213-015-4015-x","type":"journal-article","created":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T01:12:18Z","timestamp":1438391538000},"page":"3623-3636","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Brain DNA damage and behavioral changes after repeated intermittent acute ethanol withdrawal by young rats"],"prefix":"10.1007","volume":"232","author":[{"given":"Priscila A.","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson H. Z.","family":"Poli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia D. M.","family":"Sperotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinara J.","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenifer","family":"Saffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio S.","family":"Nin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena M. T.","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,2]]},"reference":[{"key":"4015_CR1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF02244208","volume":"103","author":"HA Baldwin","year":"1991","unstructured":"Baldwin HA, Rassnick S, Rivier J, Koob GF, Britton KT (1991) CRF antagonist reverses the \u201canxiogenic\u201d response to ethanol withdrawal in the rat. Psychopharmacology 103:227\u2013232","journal-title":"Psychopharmacology"},{"key":"4015_CR2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/BF02246021","volume":"125","author":"HMT Barros","year":"1996","unstructured":"Barros HMT, Miczek KA (1996) Withdrawal from oral cocaine in rats: ultrasonic vocalizations and tactile startle. Psychopharmacology (Berl) 125:379\u2013384. doi: 10.1007\/BF02246021","journal-title":"Psychopharmacology (Berl)"},{"issue":"6","key":"4015_CR3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1600-0773.1994.tb01370.x","volume":"74","author":"HM Barros","year":"1994","unstructured":"Barros HM, Tannhauser SL, Tannhauser MA, Tannhauser M (1994) The effects of GABAergic drugs on grooming behaviour in the open field. Pharmacol Toxicol 74(6):339\u201344","journal-title":"Pharmacol Toxicol"},{"key":"4015_CR4","unstructured":"Becker HC, Hale RL (1993) Repeated episodes of ethanol withdrawal potentiate the severity of subsequent withdrawal seizures: an animal model of alcohol withdrawal \u201ckindling\u201d. Alcohol Clin Exp Res 17(1):94\u201398. doi: 10.1111\/j.1530-0277.1993.tb00731"},{"key":"4015_CR5","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1097\/01.ALC.0000148101.20547.0A","volume":"28","author":"RL Bell","year":"2004","unstructured":"Bell RL, Rodd ZA, Boutwell CL, Hsu CC, Lumeng L, Murphy JM, Li T-K, McBride WJ (2004) Effects of long-term episodic access to ethanol on the expression of an alcohol deprivation effect in low alcohol-consuming rats. Alcohol Clin Exp Res 28:1867\u20131874. doi: 10.1097\/01.ALC.0000148101.20547.0A","journal-title":"Alcohol Clin Exp Res"},{"issue":"1","key":"4015_CR6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.alcohol.2006.10.001","volume":"40","author":"RL Bell","year":"2006","unstructured":"Bell RL, Kimpel MW, Rodd ZA, Strother WN, Bai F, Peper CL, Mayfield RD, Lumeng L, Crabb DW, McBride WJ, Witzmann FA (2006) Protein expression changes in the nucleus accumbens and amygdala of inbred alcohol-preferring rats given either continuous or scheduled access to ethanol. Alcohol 40(1):3\u201317. doi: 10.1016\/j.alcohol.2006.10.001","journal-title":"Alcohol"},{"key":"4015_CR7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.alcohol.2008.03.130","volume":"42","author":"RL Bell","year":"2008","unstructured":"Bell RL, Rodd ZA, Schultz JA, Peper CL, Lumeng L, Murphy JM, McBride WJ (2008) Effects of short deprivation and re-exposure intervals on the ethanol drinking behavior of selectively bred high alcohol-consuming rats. Alcohol 42:407\u2013416. doi: 10.1016\/j.alcohol.2008.03.130","journal-title":"Alcohol"},{"key":"4015_CR8","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.neuroscience.2006.07.013","volume":"142","author":"ME Bertotto","year":"2006","unstructured":"Bertotto ME, Bustos SG, Molina VA, Martijena ID (2006) Influence of ethanol withdrawal on fear memory: effect of D-cycloserine. Neuroscience 142:979\u2013990. doi: 10.1016\/j.neuroscience.2006.07.013","journal-title":"Neuroscience"},{"key":"4015_CR9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00702-002-0789-1","volume":"110","author":"S Bleich","year":"2003","unstructured":"Bleich S, Wilhelm J, Graesel E, Degner D, Sperling W, R\u00f6ssner V, Javaheripour K, Kornhuber J (2003) Apolipoprotein E epsilon 4 is associated with hippocampal volume reduction in females with alcoholism. J Neural Transm 110:401\u201311. doi: 10.1007\/s00702-002-0789-1","journal-title":"J Neural Transm"},{"key":"4015_CR10","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.alcohol.2010.11.007","volume":"45","author":"VT Bonassoli","year":"2011","unstructured":"Bonassoli VT, Milani H, de Oliveira RMW (2011) Ethanol withdrawal activates nitric oxide-producing neurons in anxiety-related brain areas. Alcohol 45:641\u2013652. doi: 10.1016\/j.alcohol.2010.11.007","journal-title":"Alcohol"},{"key":"4015_CR11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF00421386","volume":"46","author":"NW Bond","year":"1976","unstructured":"Bond NW, Di Giusto EL (1976) Effects of prenatal alcohol consumption on open-field behaviour and alcohol preference in rats. Psychopharmacologia (Berl) 46:163\u2013165","journal-title":"Psychopharmacologia (Berl)"},{"key":"4015_CR12","first-page":"1073","volume":"21","author":"PJ Brooks","year":"1997","unstructured":"Brooks PJ (1997) DNA damage, DNA repair, and alcohol toxicity\u2014a review. Alcohol Clin Exp Res 21:1073\u20131082","journal-title":"Alcohol Clin Exp Res"},{"key":"4015_CR13","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0197-0186(00)00051-6","volume":"37","author":"PJ Brooks","year":"2000","unstructured":"Brooks PJ (2000) Brain atrophy and neuronal loss in alcoholism: a role for DNA damage? Neurochem Int 37:403\u201312. doi: 10.1016\/S0197-0186(00)00051-6","journal-title":"Neurochem Int"},{"key":"4015_CR14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.alcohol.2011.09.027","volume":"46","author":"J Bustamante","year":"2012","unstructured":"Bustamante J, Karadayian AG, Lores-Arnaiz S, Cutrera RA (2012) Alterations of motor performance and brain cortex mitochondrial function during ethanol hangover. Alcohol 46:473\u2013479. doi: 10.1016\/j.alcohol.2011.09.027","journal-title":"Alcohol"},{"key":"4015_CR15","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.expneurol.2006.02.004","volume":"200","author":"A Cabral","year":"2006","unstructured":"Cabral A, Isoardi N, Salum C, Macedo CE, Nobre MJ, Molina VA, Brand\u00e3o ML (2006) Fear state induced by ethanol withdrawal may be due to the sensitization of the neural substrates of aversion in the dPAG. Exp Neurol 200:200\u2013208. doi: 10.1016\/j.expneurol.2006.02.004","journal-title":"Exp Neurol"},{"issue":"2","key":"4015_CR16","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/j.1530-0277.2010.01349.x","volume":"35","author":"CH Chen","year":"2011","unstructured":"Chen CH, Pan CH, Chen CC, Huang MC (2011) Increased oxidative DNA damage in patients with alcohol dependence and its correlation with alcohol withdrawal severity. Alcohol Clin Exp Res 35(2):338\u2013344. doi: 10.1111\/j.1530-0277.2010.01349.x","journal-title":"Alcohol Clin Exp Res"},{"issue":"2","key":"4015_CR17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.pbb.2007.12.002","volume":"89","author":"CS Chung","year":"2008","unstructured":"Chung CS, Wang J, Wehman M, Rhoads DE (2008) Severity of alcohol withdrawal symptoms depends on developmental stage of Long-Evans rats. Pharmacol Biochem Behav 89(2):137\u2013144. doi: 10.1016\/j.pbb.2007.12.002","journal-title":"Pharmacol Biochem Behav"},{"key":"4015_CR18","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s002130050889","volume":"142","author":"JC Cole","year":"1999","unstructured":"Cole JC, Littleton JM, Little HJ (1999) Effects of repeated ethanol administration in the plus maze: a simple model for conditioned abstinence behavior. Psychopharmacology 142:270\u2013279","journal-title":"Psychopharmacology"},{"key":"4015_CR19","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.pnpbp.2010.03.004","volume":"34","author":"AR Consiglio","year":"2010","unstructured":"Consiglio AR, Ramos AL, Henriques JA, Picada JN (2010) DNA brain damage after stress in rats. Prog Neuropsychopharmacol Biol Psychiatry 34:652\u2013656. doi: 10.1016\/j.pnpbp.2010.03.004","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"11","key":"4015_CR20","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1111\/j.1530-0277.2000.tb01973.x","volume":"24","author":"FT Crews","year":"2000","unstructured":"Crews FT, Braun CJ, Hoplight B, Switzer RC 3rd, Knapp DJ (2000) Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats. Alcohol Clin Exp Res 24(11):1712\u201323. doi: 10.1111\/j.1530-0277.2000.tb01973.x","journal-title":"Alcohol Clin Exp Res"},{"key":"4015_CR21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/1874473710801010003","volume":"1","author":"XS Deng","year":"2008","unstructured":"Deng XS, Deitrich RA (2008) Putative role of brain acetaldehyde in ethanol addiction. Curr Drug Abuse Rev 1:3\u20138. doi: 10.2174\/1874473710801010003","journal-title":"Curr Drug Abuse Rev"},{"issue":"9","key":"4015_CR22","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1111\/j.1530-0277.2007.00457.x","volume":"31","author":"TL Doremus-Fitzwater","year":"2007","unstructured":"Doremus-Fitzwater TL, Spear LP (2007) Developmental differences in acute ethanol withdrawal in adolescent and adult rats. Alcohol Exp Clin Res 31(9):1516\u20131527. doi: 10.1111\/j.1530-0277.2007.00457.x","journal-title":"Alcohol Exp Clin Res"},{"issue":"9","key":"4015_CR23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106945","volume":"9","author":"AK Fowler","year":"2014","unstructured":"Fowler AK, Thompson J, Chen L, Dagda M, Dertien J, Dossou KSS, Moaddel R, Bergeson SE, Kruman II (2014) Differential sensitivity of prefrontal cortex and hippocampus to alcohol-induced toxicity. PLoS One 9(9), e106945. doi: 10.1371\/journal.pone.0106945","journal-title":"PLoS One"},{"key":"4015_CR24","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.1021\/jf070440a","volume":"55","author":"L Guo","year":"2007","unstructured":"Guo L, Wang LH, Sun B, Yang JY, Zhao YQ, Dong YX, Spranger MI, Wu CF (2007) Direct in vivo evidence of protective effects of grape seed procyanidin fractions and other antioxidants against ethanol-induced oxidative DNA damage in mouse Brain Cells. J Agric Food Chem 55:5881\u20135891. doi: 10.1021\/jf070440a","journal-title":"J Agric Food Chem"},{"key":"4015_CR25","volume-title":"Free radicals in biology and medicine","author":"B Halliwell","year":"2005","unstructured":"Halliwell B, Gutteridge JMC (2005) Free radicals in biology and medicine, 4th edn. Oxford University Press, New York","edition":"4"},{"key":"4015_CR26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00005072-199802000-00001","volume":"57","author":"C Harper","year":"1998","unstructured":"Harper C (1998) The neuropathology of alcohol-specific brain damage, or does alcohol damage the brain? J Neuropathol Exp Neurol 57:101\u201310","journal-title":"J Neuropathol Exp Neurol"},{"issue":"2","key":"4015_CR27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/alcalc\/agn102","volume":"44","author":"C Harper","year":"2009","unstructured":"Harper C (2009) The neuropathology of alcohol-related brain damage. Alcohol Alcohol 44(2):136\u2013140. doi: 10.1093\/alcalc\/agn102","journal-title":"Alcohol Alcohol"},{"key":"4015_CR28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.coph.2004.06.011","volume":"5","author":"C Harper","year":"2005","unstructured":"Harper C, Matsumoto I (2005) Ethanol and brain damage. Curr Opin Pharmacol 5:73\u20138. doi: 10.1016\/j.coph.2004.06.011","journal-title":"Curr Opin Pharmacol"},{"key":"4015_CR29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0378-4274(96)03847-7","volume":"90","author":"A Hartmann","year":"1997","unstructured":"Hartmann A, Speit G (1997) The contribution of cytotoxicity to DNA-effects in the single cell gel test (comet assay). Toxicol Lett 90:183\u2013188. doi: 10.1016\/S0378-4274(96)03847-7","journal-title":"Toxicol Lett"},{"issue":"1","key":"4015_CR30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/mutage\/18.1.45","volume":"18","author":"A Hartmann","year":"2003","unstructured":"Hartmann A, Agurell E, Beevers C, Brendler-Schwaab S, Burlinson B, Clay P, Collins A, Smith A, Speit G, Thybaud V, Tice RR (2003) Recommendations for conducting the in vivo alkaline comet assay. Mutagenesis 18(1):45\u201351. doi: 10.1093\/mutage\/18.1.45","journal-title":"Mutagenesis"},{"issue":"1","key":"4015_CR31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/neu.20208","volume":"66","author":"MB Heaton","year":"2006","unstructured":"Heaton MB, Paiva M, Madorsky I, Siler-Marsiglio K, Shaw G (2006) Effect of bax deletion on ethanol sensitivity in the neonatal rat cerebellum. J Neurobiol 66(1):95\u2013101. doi: 10.1002\/neu.20208","journal-title":"J Neurobiol"},{"key":"4015_CR32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yfrne.2007.04.001","volume":"28","author":"M Jo\u00ebls","year":"2007","unstructured":"Jo\u00ebls M, Karst H, Krugers HJ, Lucassen PJ (2007) Chronic stress: implications for neuronal morphology, function and neurogenesis. Front Neuroendocrinol 28:72\u201396. doi: 10.1016\/j.yfrne.2007.04.001","journal-title":"Front Neuroendocrinol"},{"key":"4015_CR33","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/jat.1550","volume":"30","author":"V Kaefer","year":"2010","unstructured":"Kaefer V, Semedo JG, Kahl VFS, Borowsky RGV, Gianesini J, Kist TBL, Pereira P, Picada JN (2010) DNA damage in brain cells and behavioral deficits in mice after treatment with high doses of amantadine. J Appl Toxicol 30:745\u2013753. doi: 10.1002\/jat.1550","journal-title":"J Appl Toxicol"},{"key":"4015_CR34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jneumeth.2004.10.001","volume":"143","author":"AV Kalueff","year":"2005","unstructured":"Kalueff AV, Tuohimaa P (2005) The grooming analysis algorithm discriminates between different levels of anxiety in rats: potential utility for neurobehavioural stress research. J Neurosci Methods 143:169\u2013177. doi: 10.1016\/j.jneumeth.2004.10.001","journal-title":"J Neurosci Methods"},{"key":"4015_CR35","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.bbr.2013.07.011","volume":"253","author":"AG Karadayian","year":"2013","unstructured":"Karadayian AG, Busso MJ, Feleder C, Cutrera RA (2013) Alterations in affective behavior during the time course of alcohol hangover. Behav Brain Res 253:128\u2013138. doi: 10.1016\/j.bbr.2013.07.011","journal-title":"Behav Brain Res"},{"issue":"3","key":"4015_CR36","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1530-0277.2011.01634.x","volume":"36","author":"RW Logan","year":"2012","unstructured":"Logan RW, McCulley WD, Seggio JA, Rosenwasser AM (2012) Effects of withdrawal from chronic intermittent ethanol vapor on the level and circadian periodicity of running-wheel activity in C57BL\/6J and C3H\/HeJ mice. Alcohol Clin Exp Res 36(3):467\u2013476. doi: 10.1111\/j.1530-0277.2011.01634.x","journal-title":"Alcohol Clin Exp Res"},{"key":"4015_CR37","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1590\/S0100-879X1997000900009","volume":"30","author":"MS Maciera","year":"1997","unstructured":"Maciera MS, Almeida WG, Silva EA, Schenberg LC, Nakamura-Palacios EM (1997) Alcohol dependence induced in rats by semivoluntary intermittent intake. Braz J Med Biol Res 30:1107\u20131111","journal-title":"Braz J Med Biol Res"},{"issue":"5","key":"4015_CR38","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/NEN.0b013e31816ff780","volume":"67","author":"LJ Martin","year":"2008","unstructured":"Martin LJ (2008) DNA damage and repair: relevance to mechanisms of neurodegeneration. J Neuropathol Exp Neurol 67(5):377\u2013387. doi: 10.1097\/NEN.0b013e31816ff780","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"4015_CR39","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/alcalc\/agh226","volume":"41","author":"A McKinney","year":"2006","unstructured":"McKinney A, Coyle K (2006) Alcohol hangover effects on measures of affect the morning after a normal night\u2019s drinking. Alcohol Alcohol 41(1):54\u201360. doi: 10.1093\/alcalc\/agh226","journal-title":"Alcohol Alcohol"},{"issue":"12","key":"4015_CR40","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1111\/j.1530-0277.2006.00248.x","volume":"30","author":"RI Melendez","year":"2006","unstructured":"Melendez RI, Middaugh LD, Kalivas PW (2006) Development of an alcohol deprivation and escalation effect in C57BL\/6J mice. Alcohol Clin Exp Res 30(12):2017\u20132025. doi: 10.1111\/j.1530-0277.2006.00248.x","journal-title":"Alcohol Clin Exp Res"},{"key":"4015_CR41","doi-asserted-by":"crossref","unstructured":"Montoliu C, Vall\u00e9s S, Renau-Piqueras J, Guerri C (1994) Ethanol-induced oxygen radical formation and lipid peroxidation in rat brain: effect of chronic alcohol consumption. J Neurochem 63(5):1855\u20131862","DOI":"10.1046\/j.1471-4159.1994.63051855.x"},{"key":"4015_CR42","first-page":"95","volume":"684","author":"MS Nin","year":"2012","unstructured":"Nin MS, Couto-Pereira NS, Souza MF, Azeredo LA, Ferri MK, Dalpr\u00e1 WL, Gomez R, Barros HMT (2012) Anxiolytic effect of clonazepam in female rats: grooming microstructure and elevated plus maze tests. Behav Pharmacol 684:95\u2013101. doi: 10.1016\/j.ejphar.2012.03.038","journal-title":"Behav Pharmacol"},{"key":"4015_CR43","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","volume":"14","author":"S Pellow","year":"1985","unstructured":"Pellow S, Chopin P, File SE, Briley M (1985) Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14:149\u2013167. doi: 10.1016\/0165-0270(85)90031-7","journal-title":"J Neurosci Methods"},{"key":"4015_CR44","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00213-012-2866-y","volume":"225","author":"R Penning","year":"2013","unstructured":"Penning R, McKinney A, Bus LD, Olivier B, Slot K, Verster JC (2013) Measurement of alcohol hangover severity: development of the Alcohol Hangover Severity Scale (AHSS). Psychopharmacology 225:803\u2013810. doi: 10.1007\/s00213-012-2866-y","journal-title":"Psychopharmacology"},{"key":"4015_CR45","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00213-011-2483-1","volume":"220","author":"SD Philibin","year":"2012","unstructured":"Philibin SD, Cameron AJ, Schlumbohm JP, Metten P, Crabbe JC (2012) Ethanol withdrawal-induced motor impairment in mice. Psychopharmacology 220:367\u2013378. doi: 10.1007\/s00213-011-2483-1","journal-title":"Psychopharmacology"},{"key":"4015_CR46","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1369-1600.2008.00140.x","volume":"14","author":"ZA Rodd","year":"2009","unstructured":"Rodd ZA, Bell RL, Kuc KA, Murphy JM, Lumeng L, McBride WJ (2009) Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of high-alcohol-drinking (HAD) rats. Addict Biol 14:152\u2013164. doi: 10.1111\/j.1369-1600.2008.00140.x","journal-title":"Addict Biol"},{"key":"4015_CR47","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1369-1600.2012.00481.x","volume":"18","author":"AM Rosenwasser","year":"2012","unstructured":"Rosenwasser AM, Fixaris MC, Crabbe JC, Brooks PC, Ascheid S (2012) Escalation of intake under intermittent ethanol access in diverse mouse genotypes. Addict Biol 18:496\u2013507. doi: 10.1111\/j.1369-1600.2012.00481.x","journal-title":"Addict Biol"},{"key":"4015_CR48","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s00213-008-1409-z","volume":"203","author":"D Rylkova","year":"2009","unstructured":"Rylkova D, Shah HP, Small E, Bruijnzeel AW (2009) Deficit in brain reward function and acute and protracted anxiety-like behavior after discontinuation of a chronic alcohol liquid diet in rats. Psychopharmacology 203:629\u2013640. doi: 10.1007\/s00213-008-1409-z","journal-title":"Psychopharmacology"},{"key":"4015_CR49","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1369-1600.2006.00012.x","volume":"11","author":"C Sanchis-Segura","year":"2006","unstructured":"Sanchis-Segura C, Spanagel R (2006) Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addict Biol 11:2\u201338. doi: 10.1111\/j.1355-6215.2006.00012.x","journal-title":"Addict Biol"},{"issue":"6","key":"4015_CR50","first-page":"624","volume":"4","author":"P Sengupta","year":"2013","unstructured":"Sengupta P (2013) The laboratory rat: relating its age with human\u2019s. Int J Prev Med 4(6):624\u2013630","journal-title":"Int J Prev Med"},{"issue":"10","key":"4015_CR51","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/j.1530-0277.2008.00753.x","volume":"32","author":"JA Simms","year":"2008","unstructured":"Simms JA, Steensland P, Medina B, Abernathy KE, Chandler LJ, Wise R, Bartlett SE (2008) Intermittent access to 20% ethanol induces high ethanol consumption in Long\u2013Evans and Wistar rats. Alcohol Clin Exp Res 32(10):1816\u20131823. doi: 10.1111\/j.1530-0277.2008.00753.x","journal-title":"Alcohol Clin Exp Res"},{"key":"4015_CR52","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","volume":"175","author":"NP Singh","year":"1988","unstructured":"Singh NP, McCoy MT, Tice RR, Schneider EL (1988) A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res 175:184\u2013191. doi: 10.1016\/0014-4827(88)90265-0","journal-title":"Exp Cell Res"},{"key":"4015_CR53","doi-asserted-by":"crossref","unstructured":"Smith AW, Nealey KA, Wright JW, Walker BM (2011) Plasticity associated with escalated operant ethanol self-administration during acute withdrawal in ethanol-dependent rats requires intact matrix metalloproteinase systems. Neurobiol Learn Mem 96:199\u2013206","DOI":"10.1016\/j.nlm.2011.04.011"},{"issue":"4","key":"4015_CR54","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S1521-6918(03)00031-3","volume":"17","author":"R Spanagel","year":"2003","unstructured":"Spanagel R (2003) Alcohol addiction research: from animal models to clinics. Best Pract Res Clin Gastroenterol 17(4):507\u2013518. doi: 10.1053\/ybega.2003.389","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"2","key":"4015_CR55","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/alcalc\/34.2.231","volume":"34","author":"R Spanagel","year":"1999","unstructured":"Spanagel R, Holter SM (1999) Long-term alcohol self-administration with repeated alcohol deprivation phases: an animal model of alcoholism? Alcohol Alcohol 34(2):231\u2013243. doi: 10.1093\/alcalc\/34.2.231","journal-title":"Alcohol Alcohol"},{"issue":"8","key":"4015_CR56","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/acer.12101","volume":"37","author":"L Tampier","year":"2013","unstructured":"Tampier L, Quintanilla ME, Karahanian E, Rivera-Meza M, Herrera-Marschitz M, Israel Y (2013) The alcohol deprivation effect: marked inhibition by anticatalase gene administration into the ventral tegmental area in rats. Alcohol Clin Exp Res 37(8):1278\u20131285. doi: 10.1111\/acer.12101","journal-title":"Alcohol Clin Exp Res"},{"key":"4015_CR57","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.pbb.2012.04.011","volume":"102","author":"GR Villas Boas","year":"2012","unstructured":"Villas Boas GR, Zamboni CG, Peretti MC, Correia D, Rueda AVL, Camarini R, Brunialti-Godard AL, Boerngen-Lacerda R (2012) GABAB receptor agonist only reduces ethanol drinking in light-drinking mice. Pharmacol Biochem Behav 102:233\u2013240. doi: 10.1016\/j.pbb.2012.04.011","journal-title":"Pharmacol Biochem Behav"},{"issue":"5","key":"4015_CR58","volume":"7","author":"X Wang","year":"2012","unstructured":"Wang X, Ke Z, Chen G, Xu M, Bower KA, Frank JA, Zhang Z, Shi X, Luo J (2012) Cdc42-dependent activation of NADPH oxidase is involved in ethanol-induced neuronal oxidative stress. PLoS One 7(5), e38075. doi: 10.1371\/journal.pone.0038075","journal-title":"PLoS One"},{"key":"4015_CR59","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00213-012-2691-3","volume":"223","author":"AM Williams","year":"2012","unstructured":"Williams AM, Reis DJ, Powell AS, Neira LJ, Nealey KA, Ziegler CE, Kloss ND, Bilimoria JL, Smith CE, Walker BM (2012) The effect of intermittent alcohol vapor or pulsatile heroin on somatic and negative affective indices during spontaneous withdrawal in Wistar rats. Psychopharmacology 223:75\u201388. doi: 10.1007\/s00213-012-2691-3","journal-title":"Psychopharmacology"},{"key":"4015_CR60","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1383-5718(02)00070-0","volume":"518","author":"M Wojew\u00f3dzka","year":"2002","unstructured":"Wojew\u00f3dzka M, Buraczewska I, Kruszewski M (2002) A modified neutral comet assay: elimination of lysis at high temperature and validation of the assay with anti-single-stranded DNA antibody. Mutat Res 518:9\u201320, 10.1016\/S1383-5718(02)00070-0","journal-title":"Mutat Res"},{"issue":"10","key":"4015_CR61","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/sj.cdd.4401277","volume":"10","author":"C Young","year":"2003","unstructured":"Young C, Klocke BJ, Tenkova T, Choi J, Labruyere J, Qin YQ, Holtzman DM, Roth KA, Olney JW (2003) Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain. Cell Death Differ 10(10):1148\u201355. doi: 10.1038\/sj.cdd.4401277","journal-title":"Cell Death Differ"},{"key":"4015_CR62","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00213-013-3253-z","volume":"231","author":"NM Zahr","year":"2014","unstructured":"Zahr NM, Mayer D, Rohlfing T, Hsu O, Vinco S, Orduna J, Luong R, Bell RL, Sullivan EV, Pfefferbaum A (2014) Rat strain differences in brain structure and neurochemistry in response to binge alcohol. Psychopharmacology 231:429\u2013445. doi: 10.1007\/s00213-013-3253-z","journal-title":"Psychopharmacology"},{"issue":"1","key":"4015_CR63","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3109\/08958370902936931","volume":"22","author":"AC Zanchi","year":"2010","unstructured":"Zanchi AC, Saiki M, Saldiva PHN, Barros HMT, Rhoden CR (2010) Hippocampus lipid peroxidation induced by residual oil fly ash intranasal instillation versus habituation to the open field. Inhal Toxicol 22(1):84\u201388. doi: 10.1080\/08958370802009060","journal-title":"Inhal Toxicol"},{"issue":"11","key":"4015_CR64","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1111\/j.1530-0277.2007.00483.x","volume":"31","author":"Z Zhang","year":"2007","unstructured":"Zhang Z, Morse AC, Koob GF, Schulteis G (2007) Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats. Alcohol Clin Exp Res 31(11):1811\u20131819. doi: 10.1111\/j.1530-0277.2007.00483.x","journal-title":"Alcohol Clin Exp Res"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-015-4015-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-015-4015-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-015-4015-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T23:57:38Z","timestamp":1567036658000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-015-4015-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,2]]},"references-count":64,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["4015"],"URL":"https:\/\/doi.org\/10.1007\/s00213-015-4015-x","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,2]]}}}