{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T10:43:32Z","timestamp":1786790612235,"version":"build-2736575974"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T00:00:00Z","timestamp":1445990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1007\/s00213-015-4119-3","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T02:56:03Z","timestamp":1446000963000},"page":"469-484","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens"],"prefix":"10.1007","volume":"233","author":[{"given":"Magdalena","family":"Sustkova-Fiserova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Jerabek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Havlickova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Syslova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Kacer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,28]]},"reference":[{"key":"4119_CR1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.neuroscience.2011.06.001","volume":"192","author":"A Abizaid","year":"2011","unstructured":"Abizaid A, Mineur YS, Roth RH, Elsworth JD, Sleeman MW, Picciotto MR et al (2011) Reduced locomotor responses to cocaine in ghrelin-deficient mice. Neuroscience 192:500\u2013506","journal-title":"Neuroscience"},{"key":"4119_CR2","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1111\/j.1471-4159.1992.tb10033.x","volume":"58","author":"E Acquas","year":"1992","unstructured":"Acquas E, Di Chiara G (1992) Depression of mesolimbic dopamine transmission and sensitization to morphine during opiate abstinence. J Neurochem 58:1620\u20131625","journal-title":"J Neurochem"},{"issue":"Suppl 1","key":"4119_CR3","first-page":"S22","volume":"18","author":"JM Andersen","year":"2007","unstructured":"Andersen JM, Boix F, Billington C, Normann PT, Morland J (2007) Heroin, 6-MAM and morphine: locomotor activity and pharmacokinetic in mice. Behav Pharmacol 18(Suppl 1):S22\u201323","journal-title":"Behav Pharmacol"},{"issue":"43","key":"4119_CR4","doi-asserted-by":"crossref","first-page":"11052","DOI":"10.1523\/JNEUROSCI.2606-06.2006","volume":"26","author":"M Arnold","year":"2006","unstructured":"Arnold M, Mura A, Langahns W, Geary N (2006) Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in rat. J Neurosci 26(43):11052\u201311060","journal-title":"J Neurosci"},{"key":"4119_CR5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s002130100875","volume":"158","author":"C Cadoni","year":"2001","unstructured":"Cadoni C, Pisanu A, Solinas M, Acquas E, Di Chiara G (2001) Behavioral sensitization after repeated exposure to Delta 9-tetrahydrocannabinol and cross-sensitization with morphine. Psychopharmacology 158:259\u2013266","journal-title":"Psychopharmacology"},{"key":"4119_CR6","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1111\/j.1460-9568.2003.02961.x","volume":"18","author":"S Caille","year":"2003","unstructured":"Caille S, Parsons LH (2003) SR141716A reduces the reinforcing properties of heroin but not heroin-induced increases in nucleus accumbens dopamine in rats. Eur J Neurosci 18:3145\u20133149","journal-title":"Eur J Neurosci"},{"key":"4119_CR7","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/sj.npp.1300848","volume":"31","author":"S Caille","year":"2006","unstructured":"Caille S, Parsons LH (2006) Cannabinoid modulation of opiate reinforcement through the ventral striatopallidal pathway. Neuropsychopharmacology 31:804\u2013813","journal-title":"Neuropsychopharmacology"},{"issue":"14","key":"4119_CR8","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1523\/JNEUROSCI.4403-06.2007","volume":"27","author":"S Caille","year":"2007","unstructured":"Caille S, Alvarez-Jaimes L, Polis I, Stouffer DG, Parsons LH (2007) Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration. J Neurosci 27(14):3695\u20133702","journal-title":"J Neurosci"},{"key":"4119_CR9","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1079\/BJN20041256","volume":"92","author":"PD Cani","year":"2004","unstructured":"Cani PD, Montoya ML, Neyrinck AM, Delzenne NM, Lambert DM (2004) Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716 (rimonabant) and oleoylethanolamide. Br J Nutr 92:757\u2013761","journal-title":"Br J Nutr"},{"key":"4119_CR10","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s002130050518","volume":"135","author":"F Chaperon","year":"1998","unstructured":"Chaperon F, Soubrie P, Puech AJ, Thiebot MH (1998) Involvement of central cannabinoid (CB1) receptors in the establishment of place conditioning in rats. Psychopharmacol (Berl) 135:324\u2013332","journal-title":"Psychopharmacol (Berl)"},{"issue":"6","key":"4119_CR11","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1111\/j.1369-1600.2011.00339.x","volume":"17","author":"PS Clifford","year":"2012","unstructured":"Clifford PS, Rodriguez J, Schul D, Hughes S, Kniffin T, Hart N, Eitan S, Brunel L, Fehrentz JA, Martinez J, Wellman PJ (2012) Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptors. Addict Biol 17(6):956\u2013963","journal-title":"Addict Biol"},{"issue":"1","key":"4119_CR12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00213-012-2810-1","volume":"225","author":"TM D\u2019Cunha","year":"2013","unstructured":"D\u2019Cunha TM, Sedki F, Macri J, Casola C, Shalev U (2013) The effects of chronic food restriction on cue-induced heroin seeking in abstinent male rats. Psychopharmacology 225(1):241\u2013250","journal-title":"Psychopharmacology"},{"key":"4119_CR13","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1046\/j.1460-9568.1998.00368.x","volume":"10","author":"TJ Vries De","year":"1998","unstructured":"De Vries TJ, Schoffelmeer AN, Binnekade R, Mulder AH, Vanderschuren LJ (1998) Drug-induced reinstatement of heroin- and cocaine-seeking behaviour following long-term extinction is associated with expression of behavioural sensitization. Eur J Neurosci 10:3565\u20133571","journal-title":"Eur J Neurosci"},{"key":"4119_CR14","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s00213-003-1422-1","volume":"168","author":"TJ Vries De","year":"2003","unstructured":"De Vries TJ, Homberg JR, Binnekade R, Raaso H, Schoffelmeer AN (2003) Cannabinoid modulation of the reinforcing and motivational properties of heroin and heroin-associated cues in rats. Psychopharmacol (Berl) 168:164\u2013169","journal-title":"Psychopharmacol (Berl)"},{"key":"4119_CR15","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1126\/science.1470919","volume":"258","author":"WA Devane","year":"1992","unstructured":"Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258:1946\u20131949","journal-title":"Science"},{"key":"4119_CR16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0166-4328(02)00286-3","volume":"137","author":"G Chiara Di","year":"2002","unstructured":"Di Chiara G (2002) Nucleus accumbens shell and core dopamine: differential role in behavior and addiction. Behav Brain Res 137:75\u2013114","journal-title":"Behav Brain Res"},{"key":"4119_CR17","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1073\/pnas.85.14.5274","volume":"85","author":"G Chiara Di","year":"1988","unstructured":"Di Chiara G, Imperato I (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci U S A 85:5274\u20135278","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4119_CR18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/MOL.0b013e32803dbdec","volume":"18","author":"V Marzo Di","year":"2007","unstructured":"Di Marzo V, Petrosino S (2007) Endocannabinoids and the regulation of their levels in health and disease. Curr Opin Lipidol 18:29\u2013140","journal-title":"Curr Opin Lipidol"},{"key":"4119_CR19","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/372686a0","volume":"372","author":"V Marzo Di","year":"1994","unstructured":"Di Marzo V, Fontana A, Cadas H, Schinelli S, Cimino G, Schwartz JC, Piomelli D (1994) Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 372:686\u2013691","journal-title":"Nature"},{"key":"4119_CR20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0014-5793(96)00891-5","volume":"393","author":"CC Felder","year":"1996","unstructured":"Felder CC, Nielsen A, Briley EM, Palkovits M, Priller J, Axelrod J et al (1996) Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat. FEBS Lett 393:231\u2013235","journal-title":"FEBS Lett"},{"key":"4119_CR21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s002130050866","volume":"142","author":"M Fiserova","year":"1999","unstructured":"Fiserova M, Consolo S, Krsiak M (1999) Chronic morphine induces long-lasting changes in acetylcholine release in rat nucleus accumbens core and shell: an in vivo microdialysis study. Psychopharmacology 142:85\u201394","journal-title":"Psychopharmacology"},{"key":"4119_CR22","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1152\/physrev.00004.2003","volume":"83","author":"TF Freund","year":"2003","unstructured":"Freund TF, Katona I, Piomelli D (2003) Role of endogenous cannabinoids in synaptic signaling. Physiol Rev 83:1017\u20131066","journal-title":"Physiol Rev"},{"key":"4119_CR23","doi-asserted-by":"crossref","first-page":"633","DOI":"10.2174\/156800705774933069","volume":"4","author":"E Fride","year":"2005","unstructured":"Fride E (2005) Endocannabinoids in the central nervous system: from neuronal networks to behavior. Curr Drug Targets CNS Neurol Disord 4:633\u2013642","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"key":"4119_CR24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.drugalcdep.2011.01.010","volume":"117","author":"E Jerlhag","year":"2011","unstructured":"Jerlhag E, Engel JA (2011) Ghrelin receptor antagonism attenuates nicotine-induced locomotor stimulation, accumbal dopamine release and conditioned place preference in mice. Drug Alcohol Depend 117:126\u2013131","journal-title":"Drug Alcohol Depend"},{"key":"4119_CR25","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00213-010-1907-7","volume":"211","author":"E Jerlhag","year":"2010","unstructured":"Jerlhag E, Egecioglu E, Dickson SL, Engel JA (2010) Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference. Psychopharmacol (Berl) 211:415\u2013422","journal-title":"Psychopharmacol (Berl)"},{"key":"4119_CR26","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.alcohol.2010.10.002","volume":"45","author":"E Jerlhag","year":"2011","unstructured":"Jerlhag E, Landgren S, Egecioglu E, Dickson SL, Engel JA (2011) The alcohol-induced locomotor stimulation and accumbal dopamine release is suppressed in ghrelin knockout mice. Alcohol 45:341\u2013347","journal-title":"Alcohol"},{"issue":"23","key":"4119_CR27","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1523\/JNEUROSCI.0951-05.2005","volume":"25","author":"Z Justinova","year":"2008","unstructured":"Justinova Z, Solinas M, Tanda G, Redhi GH, Goldberg SR (2008) The endogenous cannabinoid anandamide and its synthetic analog R(+)-methanandamide are intravenously self-administered by squirrel monkeys. J Neurosci 25(23):5645\u20135650","journal-title":"J Neurosci"},{"key":"4119_CR28","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","volume":"402","author":"M Kojima","year":"1999","unstructured":"Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656\u2013660","journal-title":"Nature"},{"issue":"3","key":"4119_CR29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001797","volume":"3","author":"B Kola","year":"2008","unstructured":"Kola B, Farkas I, Christ-Crain M, Wittmann G, Lolli F et al (2008) The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. PLoS ONE 3(3), e1797. doi: 10.1371\/journal.pone.0001797","journal-title":"PLoS ONE"},{"issue":"1","key":"4119_CR30","first-page":"137","volume":"55","author":"SJ Konturek","year":"2004","unstructured":"Konturek SJ, Konturek JW, Pawlik T et al (2004) Brain-gut axis and its role in the control of food intake. J Physiol Pharmacol 55(1):137\u2013154","journal-title":"J Physiol Pharmacol"},{"issue":"1","key":"4119_CR31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0091-3057(85)90492-7","volume":"22","author":"WB Mackey","year":"1985","unstructured":"Mackey WB, Van der Kooy D (1985) Neuroleptics block the positive reinforcing effects of amphetamine but not of morphine measured by place conditioning. Pharmacol Biochem Behav 22(1):101\u2013105","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"4119_CR32","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1369-1600.2011.00396.x","volume":"17","author":"T Maric","year":"2012","unstructured":"Maric T, Sedki F, Ronfard B, Chafetz D, Shalev U (2012) A limited role for ghrelin in heroin self-administration and food deprivation induced reinstatement of heroin seeking in rats. Addict Biol 17(3):613\u2013622","journal-title":"Addict Biol"},{"key":"4119_CR33","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-2952(95)00109-D","volume":"50","author":"R Mechoulam","year":"1995","unstructured":"Mechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR, Gopher A, Almog S, Martin BR, Compton DR (1995) Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 50:83\u201390","journal-title":"Biochem Pharmacol"},{"key":"4119_CR34","doi-asserted-by":"crossref","first-page":"5790","DOI":"10.1021\/jm0704550","volume":"50","author":"A Moulin","year":"2007","unstructured":"Moulin A, Demange L, Berge G, Gagne D, Ryan J et al (2007) Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations. J Med Chem 50:5790\u20135806","journal-title":"J Med Chem"},{"issue":"3","key":"4119_CR35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0024-3205(86)90309-7","volume":"38","author":"RF Mucha","year":"1986","unstructured":"Mucha RF, Herz A (1986) Preference conditioning produced by opioid active and inactive isomers of levorphanol and morphine in rat. Life Sci 38(3):241\u2013249","journal-title":"Life Sci"},{"key":"4119_CR36","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1523\/JNEUROSCI.21-14-05344.2001","volume":"21","author":"M Navarro","year":"2001","unstructured":"Navarro M, Carrera MN, Fratta W, Valverde O, Cossu G, Fattore L, Chowen JA, Gomez R, Del Arco I, Villanua MA, Maldonado R, Koob GF, De Fonseca FR (2001) Functional interaction between opioid and cannabinoid receptors in drug self-administration. J Neurosci 21:5344\u20135350","journal-title":"J Neurosci"},{"key":"4119_CR37","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1194\/jlr.M400377-JLR200","volume":"46","author":"S Patel","year":"2005","unstructured":"Patel S, Carrier EJ, Ho WS, Rademacher DJ, Cunningham S, Reddy DS, Falck JR, Cravatt BF, Hillard CJ (2005) The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity. J Lipid Res 46:342\u2013349","journal-title":"J Lipid Res"},{"key":"4119_CR38","unstructured":"Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates. Sixth edition, Elsevier"},{"key":"4119_CR39","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrn1247","volume":"4","author":"D Piomelli","year":"2003","unstructured":"Piomelli D (2003) The molecular logic of endocannabinoid signalling. Nat Rev Neurosci 4:873\u2013884","journal-title":"Nat Rev Neurosci"},{"key":"4119_CR40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1527-3458.2006.00021.x","volume":"12","author":"D Piomelli","year":"2006","unstructured":"Piomelli D, Tarzia G, Duranti A, Tontini A, Mor M, Compton TR et al (2006) Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). CNS Drug Rev 12:21\u201338","journal-title":"CNS Drug Rev"},{"key":"4119_CR41","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1016\/S0014-2999(01)01056-1","volume":"421","author":"FE Pontieri","year":"2001","unstructured":"Pontieri FE, Monnazzi P, Scontrini A, Buttarelli FR, Patacchioli FR (2001a) Behavioral sensitization to heroin by cannabinoid pretreatment in the rat. Eur J Pharmacol 421:R1\u2013R3","journal-title":"Eur J Pharmacol"},{"key":"4119_CR42","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0006-8993(01)02158-8","volume":"898","author":"FE Pontieri","year":"2001","unstructured":"Pontieri FE, Monnazzi P, Scontrini A, Buttarelli FR, Patacchioli FR (2001b) Behavioral sensitization to WIN55212.2 in rats pretreated with heroin. Brain Res 898:178\u2013180","journal-title":"Brain Res"},{"key":"4119_CR43","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuint.2008.12.006","volume":"54","author":"D Quarta","year":"2009","unstructured":"Quarta D, Di Francesco C, Melotto S, Mangiarini L, Heidbreder C, Gael Hedou G (2009) Systemic administration of ghrelin increases extracellular dopamine in the shell but not the core subdivision of the nucleus accumbens. Neurochem Int 54:89\u201394","journal-title":"Neurochem Int"},{"key":"4119_CR44","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/0091-3057(95)02078-0","volume":"53","author":"P Rada","year":"1996","unstructured":"Rada P, Mark GP, Taylor KM, Hoebel BG (1996) Morphine and naloxone, i.p. or locally, affect extracellular acetylcholine in the accumbens and prefrontal cortex. Pharmacol Biochem Behav 53:809\u2013816","journal-title":"Pharmacol Biochem Behav"},{"issue":"7","key":"4119_CR45","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1523\/JNEUROSCI.10-07-02308.1990","volume":"10","author":"K Rasmussen","year":"1990","unstructured":"Rasmussen K, Beitner.Johnson DB, Krystal JH, Aghajanian GK, Nestler EJ (1990) Opiate withdrawal and rat locus coeruleus: behavioral, electrophysiological and biochemical corelates. J Neurosci 10(7):2308\u20132317","journal-title":"J Neurosci"},{"key":"4119_CR46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.psych.54.101601.145237","volume":"54","author":"TE Robinson","year":"2003","unstructured":"Robinson TE, Berridge KC (2003) Addiction. Annu Rev Psychol 54:25\u201353","journal-title":"Annu Rev Psychol"},{"key":"4119_CR47","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.brainres.2004.08.027","volume":"1026","author":"ME Singh","year":"2004","unstructured":"Singh ME, Verty AN, McGregor IS, Mallet PE (2004) A cannabinoid receptor antagonist attenuates conditioned place preference but not behavioural sensitization to morphine. Brain Res 1026:244\u2013253","journal-title":"Brain Res"},{"issue":"8","key":"4119_CR48","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.neuropharm.2005.07.008","volume":"49","author":"ME Singh","year":"2005","unstructured":"Singh ME, McGregor IS, Mallet PE (2005) Repeated exposure to Delta (9)-tetrahydrocannabinol alters heroin-induced locomotor sensitisation and Fos-immunoreactivity. Neuropharmacology 49(8):1189\u20131200","journal-title":"Neuropharmacology"},{"key":"4119_CR49","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1124\/jpet.102.047928","volume":"306","author":"M Solinas","year":"2003","unstructured":"Solinas M, Panlilio LV, Antoniou K, Pappas LA, Goldberg SR (2003) The cannabinoid CB1 antagonist N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide (SR-141716A) differentially alters the reinforcing effects of heroin under continuous reinforcement, fixed ratio, and progressive ratio schedules of drug self-administration in rats. J Pharmacol Exp Ther 306:93\u2013102","journal-title":"J Pharmacol Exp Ther"},{"key":"4119_CR50","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1038\/sj.npp.1300754","volume":"30","author":"M Solinas","year":"2005","unstructured":"Solinas M, Panlilio LV, Tanda G, Makriyannis A, Matthews SA, Goldberg SR (2005) Cannabinoid agonist but not inhibition of endogenous cannabinoid transport or metabolism enhance the reinforcing efficacy of heroin in rats. Neuropsychopharmacology 30:2046\u20132057","journal-title":"Neuropsychopharmacology"},{"key":"4119_CR51","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/bjp.2008.130","volume":"154","author":"M Solinas","year":"2008","unstructured":"Solinas M, Goldberg SR, Piomelli D (2008) The endocannabinoid system in brain reward processes. Br J Pharmacol 154:369\u2013383","journal-title":"Br J Pharmacol"},{"key":"4119_CR52","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1124\/pr.109.001933","volume":"63","author":"JD Steketee","year":"2011","unstructured":"Steketee JD, Kalivas PW (2011) Drug wanting: behavioral sensitization and relapse to drug-seeking behavior. Pharmacol Rev 63:348\u2013365","journal-title":"Pharmacol Rev"},{"key":"4119_CR53","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/bbrc.1995.2437","volume":"215","author":"T Sugiura","year":"1995","unstructured":"Sugiura T, Kondo S, Sukagawa A, Nakane S, Shinoda A, Itoh K, Yamashita A, Waku K (1995) 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun 215:89\u201397","journal-title":"Biochem Biophys Res Commun"},{"key":"4119_CR54","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.1007\/s00213-014-3466-9","volume":"231","author":"M Sustkova-Fiserova","year":"2014","unstructured":"Sustkova-Fiserova M, Jerabek P, Havlickova T, Kacer P, Krsiak M (2014) Ghrelin receptor antagonism attenuates morphine-induced accumbens dopamine release and behavioral stimulation in rats. Psychopharmacology 231:2899\u20132908","journal-title":"Psychopharmacology"},{"key":"4119_CR55","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1126\/science.276.5321.2048","volume":"276","author":"G Tanda","year":"1997","unstructured":"Tanda G, Pontieri FE, Di Chiara G (1997) Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism. Science 276:2048\u20132050","journal-title":"Science"},{"key":"4119_CR56","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/sj.bjp.0705968","volume":"143","author":"SA Tucci","year":"2004","unstructured":"Tucci SA, Rogers EK, Korbonits M, Kirkham TC (2004) The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin. Br J Pharmacol 143:520\u2013523","journal-title":"Br J Pharmacol"},{"key":"4119_CR57","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1111\/j.1460-9568.2004.03645.x","volume":"20","author":"D Vigano","year":"2004","unstructured":"Vigano D, Valenti M, Cascio MG, Di Marzo V, Parolaro D, Rubino T (2004) Changes in endocannabinoid levels in a rat model of behavioural sensitization to morphine. Eur J Neurosci 20:1849\u20131857","journal-title":"Eur J Neurosci"},{"issue":"1\u20133","key":"4119_CR58","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.regpep.2011.08.014","volume":"172","author":"PJ Wellman","year":"2011","unstructured":"Wellman PJ, Clifford PS, Rodriguez JA, Hughes S, Eitan S, Brunel L, Fehrentz JA, Martinez J (2011) Pharmacologic antagonism of ghrelin receptors attenuates development of nicotine induced locomotor sensitization in rats. Regul Pept 172(1\u20133):77\u201380","journal-title":"Regul Pept"},{"key":"4119_CR59","first-page":"171","volume":"7","author":"PJ Wellman","year":"2013","unstructured":"Wellman PJ, Clifford PS, Rodriguez JA (2013) Ghrelin and ghrelin receptor modulation of psychostimulant action. Trends Neurosci 7:171. doi: 10.3389\/fnins.2013.00171","journal-title":"Trends Neurosci"},{"issue":"5","key":"4119_CR60","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1021\/cn300036b","volume":"3","author":"J Wiskerke","year":"2012","unstructured":"Wiskerke J, Irimia C, Cravatt BF, De Vries TJ, Schoffelmeer AN, Pattij T, Parsons LH (2012) Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study. ACS Chem Neurosci 3(5):407\u201317","journal-title":"ACS Chem Neurosci"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-015-4119-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-015-4119-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-015-4119-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T21:44:28Z","timestamp":1567287868000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-015-4119-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,28]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["4119"],"URL":"https:\/\/doi.org\/10.1007\/s00213-015-4119-3","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,28]]}}}