{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T23:13:06Z","timestamp":1762125186576,"version":"3.37.3"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T00:00:00Z","timestamp":1447200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1007\/s00213-015-4133-5","type":"journal-article","created":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T00:15:47Z","timestamp":1447200947000},"page":"599-613","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A novel acetylcholinesterase inhibitor and calcium channel blocker SCR-1693 improves A\u03b225\u201335-impaired mouse cognitive function"],"prefix":"10.1007","volume":"233","author":[{"given":"Zhengping","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenji","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaoyong","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoliang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aijing","family":"Bi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhimin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,11,11]]},"reference":[{"key":"4133_CR1","doi-asserted-by":"crossref","unstructured":"Anand R, Gill KD, Mahdi AA (2014) Therapeutics of Alzheimer\u2019s disease: past, present and future. Neuropharmacology 76 Pt A: 27\u201350. doi: 10.1016\/j.neuropharm.2013.07.004","DOI":"10.1016\/j.neuropharm.2013.07.004"},{"key":"4133_CR2","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.bbadis.2011.08.013","volume":"1812","author":"TS Anekonda","year":"2011","unstructured":"Anekonda TS, Quinn JF (2011) Calcium channel blocking as a therapeutic strategy for Alzheimer\u2019s disease: the case for isradipine. Biochim Biophys Acta 1812:1584\u201390. doi: 10.1016\/j.bbadis.2011.08.013","journal-title":"Biochim Biophys Acta"},{"key":"4133_CR3","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.nbd.2010.08.020","volume":"41","author":"TS Anekonda","year":"2011","unstructured":"Anekonda TS, Quinn JF, Harris C, Frahler K, Wadsworth TL, Woltjer RL (2011) L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer\u2019s disease. Neurobiol Dis 41:62\u201370. doi: 10.1016\/j.nbd.2010.08.020","journal-title":"Neurobiol Dis"},{"key":"4133_CR4","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.tins.2008.06.005","volume":"31","author":"I Bezprozvanny","year":"2008","unstructured":"Bezprozvanny I, Mattson MP (2008) Neuronal calcium mishandling and the pathogenesis of Alzheimer\u2019s disease. Trends Neurosci 31:454\u201363. doi: 10.1016\/j.tins.2008.06.005","journal-title":"Trends Neurosci"},{"key":"4133_CR5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(06)69113-7","volume":"368","author":"K Blennow","year":"2006","unstructured":"Blennow K, de Leon MJ, Zetterberg H (2006) Alzheimer\u2019s disease. Lancet 368:387\u2013403. doi: 10.1016\/s0140-6736(06)69113-7","journal-title":"Lancet"},{"key":"4133_CR6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0092-8674(94)90400-6","volume":"79","author":"R Bourtchuladze","year":"1994","unstructured":"Bourtchuladze R, Frenguelli B, Blendy J, Cioffi D, Schutz G, Silva AJ (1994) Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 79:59\u201368. doi: 10.1016\/0092-8674(94)90400-6","journal-title":"Cell"},{"key":"4133_CR7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1021\/jm7009364","volume":"51","author":"A Cavalli","year":"2008","unstructured":"Cavalli A, Bolognesi ML, Minarini A, Rosini M, Tumiatti V, Recanatini M, Melchiorre C (2008) Multi-target-directed ligands to combat neurodegenerative diseases. J Med Chem 51:347\u201372. doi: 10.1021\/jm7009364","journal-title":"J Med Chem"},{"key":"4133_CR8","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0896-6273(01)00516-5","volume":"32","author":"KT Chang","year":"2001","unstructured":"Chang KT, Berg DK (2001) Voltage-gated channels block nicotinic regulation of CREB phosphorylation and gene expression in neurons. Neuron 32:855\u2013865","journal-title":"Neuron"},{"key":"4133_CR9","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/jnr.22345","volume":"88","author":"L Chen","year":"2010","unstructured":"Chen L, Wang H, Zhang Z, Li Z, He D, Sokabe M, Chen L (2010) DMXB (GTS-21) ameliorates the cognitive deficits in beta amyloid(25-35(\u2212) ) injected mice through preventing the dysfunction of alpha7 nicotinic receptor. J Neurosci Res 88:1784\u201394. doi: 10.1002\/jnr.22345","journal-title":"J Neurosci Res"},{"key":"4133_CR10","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1080\/10286020.2013.821982","volume":"15","author":"TY Chi","year":"2013","unstructured":"Chi TY, Wang LH, Ji XF, Shen L, Zou LB (2013) Protective effect of xanthoceraside against beta-amyloid-induced neurotoxicity in neuroblastoma SH-SY5Y cells. J Asian Nat Prod Res 15:1013\u201322. doi: 10.1080\/10286020.2013.821982","journal-title":"J Asian Nat Prod Res"},{"key":"4133_CR11","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2174\/1570159X11311030006","volume":"11","author":"M Colovic","year":"2013","unstructured":"Colovic M, Krstic D, Lazarevic-Pasti T, Bondzic A, Vasic V (2013) Acetylcholinesterase inhibitors: pharmacology and toxicology. Curr Neuropharmacol 11:315\u2013335","journal-title":"Curr Neuropharmacol"},{"key":"4133_CR12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/clpt.2013.205","volume":"95","author":"J Cummings","year":"2014","unstructured":"Cummings J, Zhong K (2014) Biomarker-driven therapeutic management of Alzheimer\u2019s disease: establishing the foundations. Clin Pharmacol Ther 95:67\u201377. doi: 10.1038\/clpt.2013.205","journal-title":"Clin Pharmacol Ther"},{"key":"4133_CR13","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/alzrt215","volume":"5","author":"D Cutuli","year":"2013","unstructured":"Cutuli D, De Bartolo P, Caporali P, Tartaglione AM, Oddi D, D\u2019Amato FR, Nobili A, D\u2019Amelio M, Petrosini L (2013) Neuroprotective effects of donepezil against cholinergic depletion. Alzheimers Res Ther 5:50. doi: 10.1186\/alzrt215","journal-title":"Alzheimers Res Ther"},{"key":"4133_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(96)00922-3","volume":"319","author":"S Delobette","year":"1997","unstructured":"Delobette S, Privat A, Maurice T (1997) In vitro aggregation facilities beta-amyloid peptide-(25\u201335)-induced amnesia in the rat. Eur J Pharmacol 319:1\u20134","journal-title":"Eur J Pharmacol"},{"key":"4133_CR15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejphar.2010.03.029","volume":"637","author":"J Deng","year":"2010","unstructured":"Deng J, Shen C, Wang YJ, Zhang M, Li J, Xu ZQ, Gao CY, Fang CQ, Zhou HD (2010) Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25\u201335 in rats. Eur J Pharmacol 637:83\u20138. doi: 10.1016\/j.ejphar.2010.03.029","journal-title":"Eur J Pharmacol"},{"key":"4133_CR16","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1042\/bj0550170","volume":"55","author":"M Dixon","year":"1953","unstructured":"Dixon M (1953) The determination of enzyme inhibitor constants. Biochem J 55:170\u2013171","journal-title":"Biochem J"},{"key":"4133_CR17","doi-asserted-by":"crossref","first-page":"913792","DOI":"10.1155\/2013\/913792","volume":"2013","author":"B Dominguez Mancera","year":"2013","unstructured":"Dominguez Mancera B, Monjaraz Guzman E, Flores-Hernandez JL, Barrientos Morales M, Martinez Hernandez JM, Hernandez Beltran A, Cervantes Acosta P (2013) Potassium current is not affected by long-term exposure to ghrelin or GHRP-6 in somatotropes GC cells. J Biophys 2013:913792. doi: 10.1155\/2013\/913792","journal-title":"J Biophys"},{"key":"4133_CR18","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1159\/000051272","volume":"12","author":"RS Doody","year":"2001","unstructured":"Doody RS, Dunn JK, Clark CM, Farlow M, Foster NL, Liao T, Gonzales N, Lai E, Massman P (2001) Chronic donepezil treatment is associated with slowed cognitive decline in Alzheimer\u2019s disease. Dement Geriatr Cogn Disord 12:295\u2013300","journal-title":"Dement Geriatr Cogn Disord"},{"key":"4133_CR19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"G Ellman","year":"1961","unstructured":"Ellman G, Courtney K, Andres VJ, Feather-Stone R (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88\u201395","journal-title":"Biochem Pharmacol"},{"key":"4133_CR20","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1523\/JNEUROSCI.0604-06.2006","volume":"26","author":"T Engel","year":"2006","unstructured":"Engel T, Hernandez F, Avila J, Lucas JJ (2006) Full reversal of Alzheimer\u2019s disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3. J Neurosci Off J Soc Neurosci 26:5083\u201390. doi: 10.1523\/JNEUROSCI.0604-06.2006","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"4133_CR21","doi-asserted-by":"crossref","first-page":"9626","DOI":"10.1523\/JNEUROSCI.0482-13.2013","volume":"33","author":"CP Figueiredo","year":"2013","unstructured":"Figueiredo CP, Clarke JR, Ledo JH, Ribeiro FC, Costa CV, Melo HM, Mota-Sales AP, Saraiva LM, Klein WL, Sebollela A, De Felice FG, Ferreira ST (2013) Memantine rescues transient cognitive impairment caused by high-molecular-weight abeta oligomers but not the persistent impairment induced by low-molecular-weight oligomers. J Neurosci Off J Soc Neurosci 33:9626\u201334. doi: 10.1523\/JNEUROSCI.0482-13.2013","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"4133_CR22","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1152\/jn.00992.2002","volume":"89","author":"DB Freir","year":"2003","unstructured":"Freir DB, Costello DA, Herron CE (2003) A beta 25-35-induced depression of long-term potentiation in area CA1 in vivo and in vitro is attenuated by verapamil. J Neurophysiol 89:3061\u20139. doi: 10.1152\/jn.00992.2002","journal-title":"J Neurophysiol"},{"key":"4133_CR23","first-page":"389","volume":"2014","author":"MA Gandini","year":"2014","unstructured":"Gandini MA, Sandoval A, Felix R (2014) Whole-cell patch-clamp recordings of Ca2+ currents from isolated neonatal mouse dorsal root ganglion (DRG) neurons. Cold Spring Harb Protoc 2014:389\u201395. doi: 10.1101\/pdb.prot073205","journal-title":"Cold Spring Harb Protoc"},{"key":"4133_CR24","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1177\/0269881110391832","volume":"25","author":"GE Ginani","year":"2011","unstructured":"Ginani GE, Tufik S, Bueno OF, Pradella-Hallinan M, Rusted J, Pompeia S (2011) Acute effects of donepezil in healthy young adults underline the fractionation of executive functioning. J Psychopharmacol 25:1508\u201316. doi: 10.1177\/0269881110391832","journal-title":"J Psychopharmacol"},{"key":"4133_CR25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1124\/dmd.110.035964","volume":"39","author":"CW Goh","year":"2011","unstructured":"Goh CW, Aw CC, Lee JH, Chen CP, Browne ER (2011) Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats. Drug Metab Dispos Biol Fate Chem 39:402\u201311. doi: 10.1124\/dmd.110.035964","journal-title":"Drug Metab Dispos Biol Fate Chem"},{"issue":"Suppl 2","key":"4133_CR26","doi-asserted-by":"crossref","first-page":"S269","DOI":"10.3233\/JAD-2012-111664","volume":"30","author":"WV Goodison","year":"2012","unstructured":"Goodison WV, Frisardi V, Kehoe PG (2012) Calcium channel blockers and Alzheimer\u2019s disease: potential relevance in treatment strategies of metabolic syndrome. J Alzheimers Dis JAD 30(Suppl 2):S269\u201382. doi: 10.3233\/JAD-2012-111664","journal-title":"J. Alzheimers Dis JAD"},{"key":"4133_CR27","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.neuron.2008.07.013","volume":"59","author":"KN Green","year":"2008","unstructured":"Green KN, LaFerla FM (2008) Linking calcium to Abeta and Alzheimer\u2019s disease. Neuron 59:190\u20134. doi: 10.1016\/j.neuron.2008.07.013","journal-title":"Neuron"},{"key":"4133_CR28","first-page":"24","volume":"110","author":"GA Jackson","year":"2014","unstructured":"Jackson GA (2014) Drug treatments for Alzheimer\u2019s disease. Nurs Times 110:24\u201326","journal-title":"Nurs Times"},{"key":"4133_CR29","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1517\/17425255.4.10.1363","volume":"4","author":"SA Jacobson","year":"2008","unstructured":"Jacobson SA, Sabbagh MN (2008) Donepezil: potential neuroprotective and disease-modifying effects. Expert Opin Drug Metab Toxicol 4:1363\u20131369","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"4133_CR30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/annonc\/mdp499","volume":"21","author":"S Jin","year":"2009","unstructured":"Jin S, Zhang QY, Kang XM, Wang JX, Zhao WH (2009) Daidzein induces MCF-7 breast cancer cell apoptosis via the mitochondrial pathway. Ann Oncol 21:263\u2013268. doi: 10.1093\/annonc\/mdp499","journal-title":"Ann Oncol"},{"key":"4133_CR31","doi-asserted-by":"crossref","first-page":"13541","DOI":"10.1074\/jbc.M008035200","volume":"276","author":"T Kihara","year":"2001","unstructured":"Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A (2001) Alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity. J Biol Chem 276:13541\u20136. doi: 10.1074\/jbc.M008035200","journal-title":"J Biol Chem"},{"key":"4133_CR32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.brainres.2005.04.014","volume":"1047","author":"M Kimura","year":"2005","unstructured":"Kimura M, Akasofu S, Ogura H, Sawada K (2005) Protective effect of donepezil against Abeta(1\u201340) neurotoxicity in rat septal neurons. Brain Res 1047:72\u201384. doi: 10.1016\/j.brainres.2005.04.014","journal-title":"Brain Res"},{"key":"4133_CR33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neuroscience.2006.11.060","volume":"145","author":"B Klementiev","year":"2007","unstructured":"Klementiev B, Novikova T, Novitskaya V, Walmod PS, Dmytriyeva O, Pakkenberg B, Berezin V, Bock E (2007) A neural cell adhesion molecule-derived peptide reduces neuropathological signs and cognitive impairment induced by Abeta25-35. Neuroscience 145:209\u201324. doi: 10.1016\/j.neuroscience.2006.11.060","journal-title":"Neuroscience"},{"key":"4133_CR34","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1113\/jphysiol.1993.sp019523","volume":"461","author":"P Kostyuk","year":"1993","unstructured":"Kostyuk P, Pronchuk N, Savchenko A, Verkhratsky A (1993) Calcium currents in aged rat dorsal root ganglion neurones. J Physiol 461:467\u2013483","journal-title":"J Physiol"},{"key":"4133_CR35","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejphar.2005.10.028","volume":"527","author":"T Kume","year":"2005","unstructured":"Kume T, Sugimoto M, Takada Y, Yamaguchi T, Yonezawa A, Katsuki H, Sugimoto H, Akaike A (2005) Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons. Eur J Pharmacol 527:77\u201385. doi: 10.1016\/j.ejphar.2005.10.028","journal-title":"Eur J Pharmacol"},{"key":"4133_CR36","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neulet.2010.10.042","volume":"487","author":"SH Kwon","year":"2011","unstructured":"Kwon SH, Lee HK, Kim JA, Hong SI, Kim SY, Jo TH, Park YI, Lee CK, Kim YB, Lee SY, Jang CG (2011) Neuroprotective effects of Eucommia ulmoides Oliv. Bark on amyloid beta(25\u201335)-induced learning and memory impairments in mice. Neurosci Lett 487:123\u20137. doi: 10.1016\/j.neulet.2010.10.042","journal-title":"Neurosci Lett"},{"key":"4133_CR37","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nrn960","volume":"3","author":"FM LaFerla","year":"2002","unstructured":"LaFerla FM (2002) Calcium dyshomeostasis and intracellular signalling in Alzheimer\u2019s disease. Nat Rev Neurosci 3:862\u201372. doi: 10.1038\/nrn960","journal-title":"Nat Rev Neurosci"},{"key":"4133_CR38","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1038\/npp.2013.70","volume":"38","author":"V Lahmy","year":"2013","unstructured":"Lahmy V, Meunier J, Malmstrom S, Naert G, Givalois L, Kim SH, Villard V, Vamvakides A, Maurice T (2013) Blockade of Tau hyperphosphorylation and Abeta(1)(\u2212)(4)(2) generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and sigma(1) receptor agonist, in a nontransgenic mouse model of Alzheimer\u2019s disease. Neuropsychopharmacology 38:1706\u201323. doi: 10.1038\/npp.2013.70","journal-title":"Neuropsychopharmacology"},{"key":"4133_CR39","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00213-011-2386-1","volume":"219","author":"P Lu","year":"2012","unstructured":"Lu P, Mamiya T, Lu L, Mouri A, Ikejima T, Kim HC, Zou LB, Nabeshima T (2012) Xanthoceraside attenuates amyloid beta peptide(2)(5)(\u2212)(3)(5)-induced learning and memory impairments in mice. Psychopharmacology 219:181\u201390. doi: 10.1007\/s00213-011-2386-1","journal-title":"Psychopharmacology"},{"key":"4133_CR40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0006-2952(93)90342-T","volume":"46","author":"S Madden","year":"1993","unstructured":"Madden S, Woolf TF, Pool WF, Park BK (1993) An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro. Biochem Pharmacol 46:13\u201320. doi: 10.1016\/0006-2952(93)90342-t","journal-title":"Biochem Pharmacol"},{"key":"4133_CR41","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/340554a0","volume":"340","author":"RC Malenka","year":"1989","unstructured":"Malenka RC, Kauer JA, Perkel DJ, Mauk MD, Kelly PT, Nicoll RA, Waxham MN (1989) An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation. Nature 340:554\u20137. doi: 10.1038\/340554a0","journal-title":"Nature"},{"key":"4133_CR42","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1021\/jm801292b","volume":"52","author":"J Marco-Contelles","year":"2009","unstructured":"Marco-Contelles J, R\u00edos Cdl RRL, Samadi A, Bartolini M, Andrisano V, Huertas O, Barril X, Luque F, Rodr\u00edguez-Franco M, L\u00f3pez B, L\u00f3pez M, Garc\u00eda A, Carreiras M, Villarroya M (2009) Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer\u2019s disease. J Med Chem 52:2724\u201332","journal-title":"J Med Chem"},{"key":"4133_CR43","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0006-8993(95)01032-7","volume":"706","author":"T Maurice","year":"1996","unstructured":"Maurice T, Lockhart BP, Privat A (1996) Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction. Brain Res 706:181\u201393","journal-title":"Brain Res"},{"key":"4133_CR44","first-page":"728983","volume":"2012","author":"M Mehta","year":"2012","unstructured":"Mehta M, Adem A, Sabbagh M (2012) New acetylcholinesterase inhibitors for Alzheimer\u2019s disease. Int J Alzheimers Dis 2012:728983. doi: 10.1155\/2012\/728983","journal-title":"Int J Alzheimers Dis"},{"key":"4133_CR45","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/sj.bjp.0706927","volume":"149","author":"J Meunier","year":"2006","unstructured":"Meunier J, Ieni J, Maurice T (2006) The anti-amnesic and neuroprotective effects of donepezil against amyloid beta 25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor. Br J Pharmacol 149:998\u20131012. doi: 10.1038\/sj.bjp.0706927","journal-title":"Br J Pharmacol"},{"key":"4133_CR46","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1046\/j.1471-4159.2001.00478.x","volume":"78","author":"M Nakajima","year":"2001","unstructured":"Nakajima M, Miura M, Aosaki T, Shirasawa A (2001) Deficiency of presenilin-1 increases calcium-dependent vulnerability of neurons to oxidative stress in vitro. J Neurochem 78:807\u2013814","journal-title":"J Neurochem"},{"key":"4133_CR47","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2119\/molmed.2010.00180","volume":"17","author":"D Paris","year":"2011","unstructured":"Paris D, Bachmeier C, Patel N, Quadros A, Volmar CH, Laporte V, Ganey J, Beaulieu-Abdelahad D, Ait-Ghezala G, Crawford F, Mullan MJ (2011) Selective antihypertensive dihydropyridines lower Abeta accumulation by targeting both the production and the clearance of Abeta across the blood-brain barrier. Mol Med 17:149\u201362. doi: 10.2119\/molmed.2010.00180","journal-title":"Mol Med"},{"key":"4133_CR48","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2174\/156720509787602861","volume":"6","author":"G Pepeu","year":"2009","unstructured":"Pepeu G, Giovannini M (2009) Cholinesterase inhibitors and beyond. Curr Alzheimer Res 6:86\u201396. doi: 10.2174\/156720509787602861","journal-title":"Curr Alzheimer Res"},{"key":"4133_CR49","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.taap.2013.10.014","volume":"274","author":"A Petzer","year":"2014","unstructured":"Petzer A, Harvey BH, Petzer JP (2014) The interactions of azure B, a metabolite of methylene blue, with acetylcholinesterase and butyrylcholinesterase. Toxicol Appl Pharmacol 274:488\u201393. doi: 10.1016\/j.taap.2013.10.014","journal-title":"Toxicol Appl Pharmacol"},{"key":"4133_CR50","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1046\/j.1471-4159.2003.02227.x","volume":"88","author":"N Pierrot","year":"2004","unstructured":"Pierrot N, Ghisdal P, Caumont A-S, Octave J-N (2004) Intraneuronal amyloid-\u03b21-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death. J Neurochem 88:1140\u20131150. doi: 10.1046\/j.1471-4159.2003.02227.x","journal-title":"J Neurochem"},{"key":"4133_CR51","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bcp.2014.01.011","volume":"88","author":"D Puzzo","year":"2014","unstructured":"Puzzo D, Lee L, Palmeri A, Calabrese G, Arancio O (2014) Behavioral assays with mouse models of Alzheimer\u2019s disease: practical considerations and guidelines. Biochem Pharmacol 88:450\u201367. doi: 10.1016\/j.bcp.2014.01.011","journal-title":"Biochem Pharmacol"},{"key":"4133_CR52","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","volume":"362","author":"HW Querfurth","year":"2010","unstructured":"Querfurth HW, LaFerla FM (2010) Alzheimer\u2019s disease. N Engl J Med 362:329\u201344. doi: 10.1056\/NEJMra0909142","journal-title":"N Engl J Med"},{"key":"4133_CR53","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11064-009-0047-0","volume":"35","author":"M Racaniello","year":"2010","unstructured":"Racaniello M, Cardinale A, Mollinari C, D\u2019Antuono M, De Chiara G, Tancredi V, Merlo D (2010) Phosphorylation changes of CaMKII, ERK1\/2, PKB\/Akt kinases and CREB activation during early long-term potentiation at Schaffer collateral-CA1 mouse hippocampal synapses. Neurochem Res 35:239\u201346. doi: 10.1007\/s11064-009-0047-0","journal-title":"Neurochem Res"},{"key":"4133_CR54","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1471-4159.2011.07447.x","volume":"119","author":"LC Reese","year":"2011","unstructured":"Reese LC, Laezza F, Woltjer R, Taglialatela G (2011) Dysregulated phosphorylation of Ca(2+)\/calmodulin-dependent protein kinase II-alpha in the hippocampus of subjects with mild cognitive impairment and Alzheimer\u2019s disease. J Neurochem 119:791\u2013804. doi: 10.1111\/j.1471-4159.2011.07447.x","journal-title":"J Neurochem"},{"key":"4133_CR55","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0006-8993(93)91300-H","volume":"603","author":"E Reuveny","year":"1993","unstructured":"Reuveny E, Narahashi T (1993) Two types of high voltage-activated calcium channels in SH-SY5Y human neuroblastoma cells. Brain Res 603:64\u201373. doi: 10.1016\/0006-8993(93)91300-h","journal-title":"Brain Res"},{"key":"4133_CR56","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neulet.2009.10.029","volume":"467","author":"CJ Ruan","year":"2009","unstructured":"Ruan CJ, Si JY, Zhang L, Chen DH, Du GH, Su L (2009) Protective effect of stilbenes containing extract-fraction from Cajanus cajan L. on Abeta (25\u201335)-induced cognitive deficits in mice. Neurosci Lett 467:159\u201363. doi: 10.1016\/j.neulet.2009.10.029","journal-title":"Neurosci Lett"},{"key":"4133_CR57","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1517\/14656566.8.7.1011","volume":"8","author":"B Seltzer","year":"2007","unstructured":"Seltzer B (2007) Donepezil: an update. Expert Opin Pharmacother 8:1011\u20131023","journal-title":"Expert Opin Pharmacother"},{"key":"4133_CR58","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/35086072","volume":"2","author":"DH Small","year":"2001","unstructured":"Small DH, Mok SS, Bornstein JC (2001) Alzheimer\u2019s disease and A\u03b2 toxicity: from top to bottom. Nat Rev Neurosci 2:595\u2013598","journal-title":"Nat Rev Neurosci"},{"key":"4133_CR59","doi-asserted-by":"crossref","first-page":"e59293","DOI":"10.1371\/journal.pone.0059293","volume":"8","author":"SR Sousa","year":"2013","unstructured":"Sousa SR, Vetter I, Ragnarsson L, Lewis RJ (2013) Expression and pharmacology of endogenous Cav channels in SH-SY5Y human neuroblastoma cells. PLoS One 8:e59293. doi: 10.1371\/journal.pone.0059293","journal-title":"PLoS One"},{"key":"4133_CR60","doi-asserted-by":"crossref","first-page":"6642","DOI":"10.1523\/JNEUROSCI.6008-11.2012","volume":"32","author":"RI Stanika","year":"2012","unstructured":"Stanika RI, Villanueva I, Kazanina G, Andrews SB, Pivovarova NB (2012) Comparative impact of voltage-gated calcium channels and NMDA receptors on mitochondria-mediated neuronal injury. J Neurosci Off J Soc Neurosci 32:6642\u201350. doi: 10.1523\/JNEUROSCI.6008-11.2012","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"4133_CR61","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0361-9230(03)00118-7","volume":"61","author":"MY Stepanichev","year":"2003","unstructured":"Stepanichev MY, Moiseeva YV, Lazareva NA, Onufriev MV, Gulyaeva NV (2003) Single intracerebroventricular administration of amyloid-beta (25\u201335) peptide induces impairment in short-term rather than long-term memory in rats. Brain Res Bull 61:197\u2013205. doi: 10.1016\/s0361-9230(03)00118-7","journal-title":"Brain Res Bull"},{"key":"4133_CR62","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.physbeh.2003.11.003","volume":"80","author":"MY Stepanichev","year":"2004","unstructured":"Stepanichev MY, Zdobnova IM, Zarubenko II, Moiseeva YV, Lazareva NA, Onufriev MV, Gulyaeva NV (2004) Amyloid-\u03b2(25\u201335)-induced memory impairments correlate with cell loss in rat hippocampus. Physiol Behav 80:647\u2013655. doi: 10.1016\/j.physbeh.2003.11.003","journal-title":"Physiol Behav"},{"key":"4133_CR63","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2174\/0929867003375191","volume":"7","author":"H Sugimoto","year":"2000","unstructured":"Sugimoto H, Yamanishi Y, Iimura Y, Kawakami Y (2000) Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors. Curr Med Chem 7:303\u2013339","journal-title":"Curr Med Chem"},{"key":"4133_CR64","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuropharm.2015.05.020","volume":"97","author":"C Wang","year":"2015","unstructured":"Wang C, Chen T, Li G, Zhou L, Sha S, Chen L (2015) Simvastatin prevents beta-amyloid-impaired neurogenesis in hippocampal dentate gyrus through alpha7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate. Neuropharmacology 97:122\u2013132. doi: 10.1016\/j.neuropharm.2015.05.020","journal-title":"Neuropharmacology"},{"key":"4133_CR65","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3233\/JAD-140597","volume":"42","author":"Y Xia","year":"2014","unstructured":"Xia Y, Liu R, Chen R, Tian Q, Zeng K, Hu J, Liu X, Wang Q, Wang P, Wang XC, Wang JZ (2014) Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and neuropathologies in rats. J Alzheimers Dis JAD 42:1029\u201339. doi: 10.3233\/JAD-140597","journal-title":"J Alzheimers Dis JAD"},{"key":"4133_CR66","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF03020488","volume":"49","author":"M Yamakage","year":"2002","unstructured":"Yamakage M, Namiki A (2002) Calcium channels\u2014basic aspects of their structure, function and gene encoding; anesthetic action on the channels\u2014a review. Can J Anaesth 49:151\u2013164","journal-title":"Can J Anaesth"},{"key":"4133_CR67","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00213-011-2291-7","volume":"217","author":"MC Yang","year":"2011","unstructured":"Yang MC, Lung FW (2011) Neuroprotection of paliperidone on SH-SY5Y cells against beta-amyloid peptide(25\u201335), N-methyl-4-phenylpyridinium ion, and hydrogen peroxide-induced cell death. Psychopharmacology 217:397\u2013410. doi: 10.1007\/s00213-011-2291-7","journal-title":"Psychopharmacology"},{"key":"4133_CR68","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.neuropharm.2012.07.035","volume":"63","author":"R Yang","year":"2012","unstructured":"Yang R, Chen L, Wang H, Xu B, Tomimoto H, Chen L (2012) Anti-amnesic effect of neurosteroid PREGS in Abeta25-35-injected mice through sigma1 receptor- and alpha7nAChR-mediated neuroprotection. Neuropharmacology 63:1042\u201350. doi: 10.1016\/j.neuropharm.2012.07.035","journal-title":"Neuropharmacology"},{"key":"4133_CR69","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.pneurobio.2009.07.009","volume":"89","author":"JT Yu","year":"2009","unstructured":"Yu JT, Chang RC, Tan L (2009) Calcium dysregulation in Alzheimer\u2019s disease: from mechanisms to therapeutic opportunities. Prog Neurobiol 89:240\u201355. doi: 10.1016\/j.pneurobio.2009.07.009","journal-title":"Prog Neurobiol"},{"key":"4133_CR70","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/cns.12190","volume":"20","author":"WH Zhi","year":"2014","unstructured":"Zhi WH, Zeng YY, Lu ZH, Qu WJ, Chen WX, Chen L, Chen L (2014) Simvastatin exerts antiamnesic effect in Abeta25-35-injected mice. CNS Neurosci Ther 20:218\u201326. doi: 10.1111\/cns.12190","journal-title":"CNS Neurosci Ther"},{"key":"4133_CR71","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ajpath.2011.03.021","volume":"179","author":"C Zussy","year":"2011","unstructured":"Zussy C, Brureau A, Delair B, Marchal S, Keller E, Ixart G, Naert G, Meunier J, Chevallier N, Maurice T, Givalois L (2011) Time-course and regional analyses of the physiopathological changes induced after cerebral injection of an amyloid beta fragment in rats. Am J Pathol 179:315\u201334. doi: 10.1016\/j.ajpath.2011.03.021","journal-title":"Am J Pathol"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-015-4133-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-015-4133-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-015-4133-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T10:53:21Z","timestamp":1718189601000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-015-4133-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,11]]},"references-count":71,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["4133"],"URL":"https:\/\/doi.org\/10.1007\/s00213-015-4133-5","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"type":"print","value":"0033-3158"},{"type":"electronic","value":"1432-2072"}],"subject":[],"published":{"date-parts":[[2015,11,11]]}}}