{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:13:43Z","timestamp":1791357223451,"version":"4.3.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T00:00:00Z","timestamp":1488844800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s00213-017-4573-1","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T00:36:33Z","timestamp":1488846993000},"page":"1703-1711","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical profile of suvorexant for the treatment of insomnia over 3\u00a0months in women and men: subgroup analysis of pooled phase-3 data"],"prefix":"10.1007","volume":"234","author":[{"given":"W. Joseph","family":"Herring","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duane B.","family":"Snavely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Hutzelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Matzura-Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth M.","family":"Benca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Krystal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Lines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Michelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"4573_CR1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2000","unstructured":"American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association, Washington","edition":"4"},{"key":"4573_CR2","doi-asserted-by":"crossref","first-page":"10980","DOI":"10.1073\/pnas.1524484113","volume":"113","author":"DB Boivin","year":"2016","unstructured":"Boivin DB, Shechter A, Boudreau P, Begum EA, Ng Ying-Kin NM (2016) Diurnal and circadian variation of sleep and alertness in men vs. naturally cycling women. Proc Natl Acad Sci U S A 113:10980\u201310985","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4573_CR3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.biopsych.2007.03.001","volume":"62","author":"KP Cosgrove","year":"2007","unstructured":"Cosgrove KP, Mazure CM, Staley JK (2007) Evolving knowledge of sex differences in brain structure, function, and chemistry. Biol Psychiatry 62:847\u2013855","journal-title":"Biol Psychiatry"},{"key":"4573_CR4","doi-asserted-by":"crossref","first-page":"5320","DOI":"10.1021\/jm100541c","volume":"53","author":"CD Cox","year":"2010","unstructured":"Cox CD, Breslin MJ, Whitman DB, Schreier JD, McGaughey GB, Bogusky MJ, Roecker AJ, Mercer SP, Bednar RA, Lemaire W, Bruno JG, Reiss DR, Harrell CM, Murphy KL, Garson SL, Doran SM, Prueksaritanont T, Anderson WB, Tang C, Roller S, Cabalu TD, Cui D, Hartman GD, Young SD, Koblan KS, Winrow CJ, Renger JJ, Coleman PJ (2010) Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H \u22121,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia. J Med Chem 53:5320\u20135332","journal-title":"J Med Chem"},{"key":"4573_CR5","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1177\/0269881109105788","volume":"24","author":"DJ Dijk","year":"2010","unstructured":"Dijk DJ, James LM, Peters S, Walsh JK, Deacon S (2010) Sex differences and the effect of gaboxadol and zolpidem on EEG power spectra in NREM and REM sleep. J Psychopharmacol 24:1613\u20131618","journal-title":"J Psychopharmacol"},{"key":"4573_CR6","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1056\/NEJMp1307972","volume":"369","author":"RH Farkas","year":"2013","unstructured":"Farkas RH, Unger EF, Temple R (2013) Zolpidem and driving impairment\u2014identifying persons at risk. N Engl J Med 369:689\u2013691","journal-title":"N Engl J Med"},{"key":"4573_CR7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.phrs.2006.11.001","volume":"55","author":"F Franconi","year":"2007","unstructured":"Franconi F, Brunelleschi S, Steardo L, Cuomo V (2007) Gender differences in drug responses. Pharmacol Res 55:81\u201395","journal-title":"Pharmacol Res"},{"key":"4573_CR8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1146\/annurev.pharmtox.44.101802.121453","volume":"44","author":"M Gandhi","year":"2004","unstructured":"Gandhi M, Aweeka F, Greenblatt RM, Blaschke TF (2004) Sex differences in pharmacokinetics and pharmacodynamics. Annu Rev Pharmacol Toxicol 44:499\u2013523","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"4573_CR9","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1212\/WNL.0b013e31827688ee","volume":"79","author":"WJ Herring","year":"2012","unstructured":"Herring WJ, Snyder E, Budd K, Hutzelmann J, Snavely D, Liu K, Lines C, Roth T, Michelson D (2012) Orexin receptor antagonism for treatment of insomnia: a randomized clinical trial of suvorexant. Neurology 79:2265\u20132274","journal-title":"Neurology"},{"key":"4573_CR10","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.biopsych.2014.10.003","volume":"79","author":"WJ Herring","year":"2016","unstructured":"Herring WJ, Connor KM, Ivgy-May N, Snyder E, Liu K, Snavely DB, Krystal AD, Walsh JK, Benca RM, Rosenberg R, Sangal RB, Budd K, Hutzelmann J, Leibensperger H, Froman S, Lines C, Roth T, Michelson D (2016) Suvorexant in patients with insomnia: results from two 3-month randomized controlled clinical trials. Biol Psychiatry 79:136\u2013148","journal-title":"Biol Psychiatry"},{"key":"4573_CR11","unstructured":"Jacobson R (2014) Psychotropic drugs affect men and women differently. Scientific American Mind July 1 2014. http:\/\/www.scientificamerican.com\/article\/psychotropic-drugs-affect-men-and-women-differently\/ Accessed November 18, 2016."},{"key":"4573_CR12","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1089\/jwh.2014.4816","volume":"23","author":"MP Mallampalli","year":"2014","unstructured":"Mallampalli MP, Carter CL (2014) Exploring sex and gender differences in sleep health: a Society for Women's Health Research report. J Women's Health (Larchmt) 23:553\u2013562","journal-title":"J Women's Health (Larchmt)"},{"key":"4573_CR13","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S1474-4422(14)70053-5","volume":"13","author":"D Michelson","year":"2014","unstructured":"Michelson D, Snyder E, Paradis E, Chengan-Liu M, Snavely DB, Hutzelmann J, Walsh JK, Krystal AD, Benca RM, Cohn M, Lines C, Roth T, Herring WJ (2014) Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial. Lancet Neurol 13:461\u2013471","journal-title":"Lancet Neurol"},{"key":"4573_CR14","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s40263-012-0036-8","volume":"27","author":"M Mieda","year":"2013","unstructured":"Mieda M, Sakurai T (2013) Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status. CNS Drugs 27:83\u201390","journal-title":"CNS Drugs"},{"key":"4573_CR15","doi-asserted-by":"crossref","first-page":"16107","DOI":"10.1523\/JNEUROSCI.4175-11.2011","volume":"31","author":"JA Mong","year":"2011","unstructured":"Mong JA, Baker FC, Mahoney MM, Paul KN, Schwartz MD, Semba K, Silver R (2011) Sleep, rhythms, and the endocrine brain: influence of sex and gonadal hormones. J Neurosci 31:16107\u201316116","journal-title":"J Neurosci"},{"key":"4573_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17241\/smr.2013.4.1.1","volume":"4","author":"S Nowakowski","year":"2013","unstructured":"Nowakowski S, Meers J, Heimbach E (2013) Sleep and women's health. Sleep Med Res 4:1\u201322","journal-title":"Sleep Med Res"},{"key":"4573_CR17","doi-asserted-by":"crossref","first-page":"30","DOI":"10.5664\/jcsm.27707","volume":"6","author":"T Roth","year":"2010","unstructured":"Roth T, Lines C, Vandormael K, Ceesay P, Anderson D, Snavely D (2010) Effect of gaboxadol on patient-reported measures of sleep and waking function in patients with primary insomnia: results from two randomized, controlled, 3-month studies. J Clin Sleep Med 6:30\u201339","journal-title":"J Clin Sleep Med"},{"key":"4573_CR18","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1007\/s13311-012-0148-3","volume":"9","author":"T Roehrs","year":"2012","unstructured":"Roehrs T, Roth T (2012) Insomnia pharmacotherapy. Neurotherapeutics 9:728\u2013738","journal-title":"Neurotherapeutics"},{"key":"4573_CR19","doi-asserted-by":"crossref","unstructured":"Sun H, Kennedy WP, Wilbraham D, Lewis N, Calder N, Li X, Ma J, Yee KL, Ermlich S, Mangin E, Lines C, Rosen L, Chodakewitz J, Murphy GM (2013) Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men. Sleep 36:259\u2013267","DOI":"10.5665\/sleep.2386"},{"key":"4573_CR20","doi-asserted-by":"crossref","unstructured":"Svetnik V, Snyder ES, Ma J, Tao P, Lines C, Herring WJ (2017) EEG spectral analysis of NREM sleep in a large sample of patients with insomnia and good sleepers: effects of age, sex and part of the night. J Sleep Res 26:92\u2013104","DOI":"10.1111\/jsr.12448"},{"key":"4573_CR21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3109\/01677063.2011.566953","volume":"25","author":"CJ Winrow","year":"2011","unstructured":"Winrow CJ, Gotter AL, Cox CD, Doran SM, Tannenbaum PL, Breslin MJ, Garson SL, Fox SV, Harrell CM, Stevens J, Reiss DR, Cui D, Coleman PJ, Renger JJ (2011) Promotion of sleep by suvorexant-a novel dual orexin receptor antagonist. J Neurogenet 25:52\u201361","journal-title":"J Neurogenet"},{"key":"4573_CR22","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/bph.12261","volume":"171","author":"CJ Winrow","year":"2014","unstructured":"Winrow CJ, Renger JJ (2014) Discovery and development of orexin receptor antagonists as therapeutics for insomnia. Br J Pharmacol 171:283\u2013293","journal-title":"Br J Pharmacol"},{"key":"4573_CR23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/sleep\/29.1.85","volume":"29","author":"B Zhang","year":"2006","unstructured":"Zhang B, Wing YK (2006) Sex differences in insomnia: a meta-analysis. Sleep 29:85\u201393","journal-title":"Sleep"},{"key":"4573_CR24","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s00228-008-0494-6","volume":"64","author":"Y Zopf","year":"2008","unstructured":"Zopf Y, Rabe C, Neubert A, Gassmann KG, Rascher W, Hahn EG, Brune K, Dormann H (2008) Women encounter ADRs more often than do men. Eur J Clin Pharmacol 64:999\u20131004","journal-title":"Eur J Clin Pharmacol"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-017-4573-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-017-4573-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-017-4573-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T12:21:57Z","timestamp":1601727717000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-017-4573-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,7]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["4573"],"URL":"https:\/\/doi.org\/10.1007\/s00213-017-4573-1","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,7]]}}}