{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T04:48:12Z","timestamp":1768798092648,"version":"3.49.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"13","license":[{"start":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:00:00Z","timestamp":1491350400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100009670","name":"NARSAD","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"crossref"}]},{"name":"RPF Roche"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1007\/s00213-017-4611-z","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T08:10:16Z","timestamp":1491379816000},"page":"2047-2062","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A schizophrenia relevant 5-Choice Serial Reaction Time Task for mice assessing broad monitoring, distractibility and impulsivity"],"prefix":"10.1007","volume":"234","author":[{"given":"Huiping","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Guadagna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maddalena","family":"Mereu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariasole","family":"Ciampoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Pruzzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Ballard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Papaleo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,4,5]]},"reference":[{"key":"4611_CR1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.pbb.2008.08.025","volume":"93","author":"N Amitai","year":"2009","unstructured":"Amitai N, Markou A (2009) Increased impulsivity and disrupted attention induced by repeated phencyclidine are not attenuated by chronic quetiapine treatment. Pharmacol Biochem Behav 93:248\u2013257","journal-title":"Pharmacol Biochem Behav"},{"key":"4611_CR2","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1037\/a0024722","volume":"125","author":"N Amitai","year":"2011","unstructured":"Amitai N, Markou A (2011) Comparative effects of different test day challenges on performance in the 5-choice serial reaction time task. Behav Neurosci 125:764\u2013774","journal-title":"Behav Neurosci"},{"key":"4611_CR3","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00213-007-0808-x","volume":"193","author":"N Amitai","year":"2007","unstructured":"Amitai N, Semenova S, Markou A (2007) Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats. Psychopharmacology 193:521\u2013537","journal-title":"Psychopharmacology"},{"key":"4611_CR4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.ajp.2013.09.002","volume":"6","author":"M Amr","year":"2013","unstructured":"Amr M, Volpe FM (2013) Relationship between anhedonia and impulsivity in schizophrenia, major depression and schizoaffective disorder. Asian J Psychiatr 6:577\u2013580","journal-title":"Asian J Psychiatr"},{"key":"4611_CR5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s00213-002-1385-7","volume":"167","author":"C Balducci","year":"2003","unstructured":"Balducci C, Nurra M, Pietropoli A, Samanin R, Carli M (2003) Reversal of visual attention dysfunction after AMPA lesions of the nucleus basalis magnocellularis (NBM) by the cholinesterase inhibitor donepezil and by a 5-HT1A receptor antagonist WAY 100635. Psychopharmacology 167:28\u201336","journal-title":"Psychopharmacology"},{"key":"4611_CR6","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1093\/cercor\/11.11.1056","volume":"11","author":"A Barbelivien","year":"2001","unstructured":"Barbelivien A, Ruotsalainen S, Sirvio J (2001) Metabolic alterations in the prefrontal and cingulate cortices are related to behavioral deficits in a rodent model of attention-deficit hyperactivity disorder. Cereb Cortex 11:1056\u20131063","journal-title":"Cereb Cortex"},{"key":"4611_CR7","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nprot.2008.41","volume":"3","author":"A Bari","year":"2008","unstructured":"Bari A, Dalley JW, Robbins TW (2008) The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats. Nat Protoc 3:759\u2013767","journal-title":"Nat Protoc"},{"key":"4611_CR8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbr.2012.07.028","volume":"235","author":"DW Bayless","year":"2012","unstructured":"Bayless DW, Darling JS, Stout WJ, Daniel JM (2012) Sex differences in attentional processes in adult rats as measured by performance on the 5-choice serial reaction time task. Behav Brain Res 235:48\u201354","journal-title":"Behav Brain Res"},{"key":"4611_CR9","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1037\/h0043220","volume":"20","author":"LH Beck","year":"1956","unstructured":"Beck LH, Bransome ED Jr, Mirsky AF, Rosvold HE, Sarason I (1956) A continuous performance test of brain damage. J Consult Psychol 20:343\u2013350","journal-title":"J Consult Psychol"},{"key":"4611_CR10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0022-3956(94)90012-4","volume":"28","author":"L Bowen","year":"1994","unstructured":"Bowen L, Wallace CJ, Glynn SM, Nuechterlein KH, Lutzker JR, Kuehnel TG (1994) Schizophrenic individuals\u2019 cognitive functioning and performance in interpersonal interactions and skills training procedures. J Psychiatr Res 28:289\u2013301","journal-title":"J Psychiatr Res"},{"key":"4611_CR11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbr.2012.01.046","volume":"230","author":"CL Burton","year":"2012","unstructured":"Burton CL, Fletcher PJ (2012) Age and sex differences in impulsive action in rats: the role of dopamine and glutamate. Behav Brain Res 230:21\u201333","journal-title":"Behav Brain Res"},{"key":"4611_CR12","unstructured":"Bushnell PJ (2001) Assessing attention in rats. In: Buccafusco JJ (ed) Methods of behavior analysis in neuroscience. CRC Press, Boca Raton, pp 111\u2013122"},{"key":"4611_CR13","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00213-010-2066-6","volume":"214","author":"M Carli","year":"2011","unstructured":"Carli M, Calcagno E, Mainini E, Arnt J, Invernizzi RW (2011a) Sertindole restores attentional performance and suppresses glutamate release induced by the NMDA receptor antagonist CPP. Psychopharmacology 214:625\u2013637","journal-title":"Psychopharmacology"},{"key":"4611_CR14","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00213-010-2065-7","volume":"214","author":"M Carli","year":"2011","unstructured":"Carli M, Calcagno E, Mainolfi P, Mainini E, Invernizzi RW (2011b) Effects of aripiprazole, olanzapine, and haloperidol in a model of cognitive deficit of schizophrenia in rats: relationship with glutamate release in the medial prefrontal cortex. Psychopharmacology 214:639\u2013652","journal-title":"Psychopharmacology"},{"key":"4611_CR15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0166-4328(83)90138-9","volume":"9","author":"M Carli","year":"1983","unstructured":"Carli M, Robbins TW, Evenden JL, Everitt BJ (1983) Effects of lesions to ascending noradrenergic neurones on performance of a 5-choice serial reaction task in rats; implications for theories of dorsal noradrenergic bundle function based on selective attention and arousal. Behav Brain Res 9:361\u2013380","journal-title":"Behav Brain Res"},{"key":"4611_CR16","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/schbul\/sbm081","volume":"33","author":"CS Carter","year":"2007","unstructured":"Carter CS, Barch DM (2007) Cognitive neuroscience-based approaches to measuring and improving treatment effects on cognition in schizophrenia: the CNTRICS initiative. Schizophr Bull 33:1131\u20131137","journal-title":"Schizophr Bull"},{"key":"4611_CR17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.biopsych.2008.03.020","volume":"64","author":"CS Carter","year":"2008","unstructured":"Carter CS, Barch DM, Buchanan RW, Bullmore E, Krystal JH, Cohen J, Geyer M, Green M, Nuechterlein KH, Robbins T, Silverstein S, Smith EE, Strauss M, Wykes T, Heinssen R (2008) Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative. Biol Psychiatry 64:4\u201310","journal-title":"Biol Psychiatry"},{"key":"4611_CR18","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/01.wco.0000247613.28859.77","volume":"19","author":"SR Chamberlain","year":"2006","unstructured":"Chamberlain SR, Muller U, Robbins TW, Sahakian BJ (2006) Neuropharmacological modulation of cognition. Curr Opin Neurol 19:607\u2013612","journal-title":"Curr Opin Neurol"},{"key":"4611_CR19","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbr.2003.09.020","volume":"146","author":"Y Chudasama","year":"2003","unstructured":"Chudasama Y, Passetti F, Rhodes SE, Lopian D, Desai A, Robbins TW (2003) Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity. Behav Brain Res 146:105\u2013119","journal-title":"Behav Brain Res"},{"key":"4611_CR20","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.neubiorev.2004.09.006","volume":"28","author":"JW Dalley","year":"2004","unstructured":"Dalley JW, Cardinal RN, Robbins TW (2004) Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates. Neurosci Biobehav Rev 28:771\u2013784","journal-title":"Neurosci Biobehav Rev"},{"key":"4611_CR21","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neuron.2011.01.020","volume":"69","author":"JW Dalley","year":"2011","unstructured":"Dalley JW, Everitt Barry J, Robbins Trevor W (2011) Impulsivity, compulsivity, and top-down cognitive control. Neuron 69:680\u2013694","journal-title":"Neuron"},{"key":"4611_CR22","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1126\/science.1137073","volume":"315","author":"JW Dalley","year":"2007","unstructured":"Dalley JW, Fryer TD, Brichard L, Robinson ES, Theobald DE, Laane K, Pena Y, Murphy ER, Shah Y, Probst K, Abakumova I, Aigbirhio FI, Richards HK, Hong Y, Baron JC, Everitt BJ, Robbins TW (2007) Nucleus accumbens D2\/3 receptors predict trait impulsivity and cocaine reinforcement. Science 315:1267\u20131270","journal-title":"Science"},{"key":"4611_CR23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00213-002-1215-y","volume":"164","author":"JW Dalley","year":"2002","unstructured":"Dalley JW, Theobald DE, Pereira EA, Li PM, Robbins TW (2002) Specific abnormalities in serotonin release in the prefrontal cortex of isolation-reared rats measured during behavioural performance of a task assessing visuospatial attention and impulsivity. Psychopharmacology 164:329\u2013340","journal-title":"Psychopharmacology"},{"key":"4611_CR24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.yfrne.2014.03.003","volume":"35","author":"W Davies","year":"2014","unstructured":"Davies W (2014) Sex differences in attention deficit hyperactivity disorder: candidate genetic and endocrine mechanisms. Front Neuroendocrinol 35:331\u2013346","journal-title":"Front Neuroendocrinol"},{"key":"4611_CR25","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.biopsych.2009.01.001","volume":"66","author":"W Davies","year":"2009","unstructured":"Davies W, Humby T, Kong W, Otter T, Burgoyne PS, Wilkinson LS (2009) Converging pharmacological and genetic evidence indicates a role for steroid sulfatase in attention. Biol Psychiatry 66:360\u2013367","journal-title":"Biol Psychiatry"},{"key":"4611_CR26","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1038\/npp.2014.115","volume":"39","author":"W Davies","year":"2014","unstructured":"Davies W, Humby T, Trent S, Eddy JB, Ojarikre OA, Wilkinson LS (2014) Genetic and pharmacological modulation of the steroid sulfatase axis improves response control; comparison with drugs used in ADHD. Neuropsychopharmacology 39:2622\u20132632","journal-title":"Neuropsychopharmacology"},{"key":"4611_CR27","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.physbeh.2006.08.009","volume":"89","author":"NM Bruin de","year":"2006","unstructured":"de Bruin NM, Fransen F, Duytschaever H, Grantham C, Megens AA (2006) Attentional performance of (C57BL\/6Jx129Sv)F2 mice in the five-choice serial reaction time task. Physiol Behav 89:692\u2013703","journal-title":"Physiol Behav"},{"key":"4611_CR28","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1037\/a0013712","volume":"22","author":"E Demeter","year":"2008","unstructured":"Demeter E, Sarter M, Lustig C (2008) Rats and humans paying attention: cross-species task development for translational research. Neuropsychology 22:787\u2013799","journal-title":"Neuropsychology"},{"key":"4611_CR29","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neubiorev.2009.07.003","volume":"34","author":"DM Eagle","year":"2010","unstructured":"Eagle DM, Baunez C (2010) Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition. Neurosci Biobehav Rev 34:50\u201372","journal-title":"Neurosci Biobehav Rev"},{"key":"4611_CR30","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000013877","volume":"5","author":"C Escera","year":"2000","unstructured":"Escera C, Alho K, Schroger E, Winkler I (2000) Involuntary attention and distractibility as evaluated with event-related brain potentials. Audiol Neurootol 5:151\u2013166","journal-title":"Audiol Neurootol"},{"key":"4611_CR31","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.brainres.2009.02.070","volume":"1273","author":"C Fassbender","year":"2009","unstructured":"Fassbender C, Zhang H, Buzy WM, Cortes CR, Mizuiri D, Beckett L, Schweitzer JB (2009) A lack of default network suppression is linked to increased distractibility in ADHD. Brain Res 1273:114\u2013128","journal-title":"Brain Res"},{"key":"4611_CR32","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1749-6632.1992.tb22843.x","volume":"658","author":"JM Ford","year":"1992","unstructured":"Ford JM, Pfefferbaum A, Roth W (1992) P3 and Schizophreniaa. Ann N Y Acad Sci 658:146\u2013162","journal-title":"Ann N Y Acad Sci"},{"key":"4611_CR33","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1037\/0735-7044.118.2.290","volume":"118","author":"MH Gendle","year":"2004","unstructured":"Gendle MH, White TL, Strawderman M, Mactutus CF, Booze RM, Levitsky DA, Strupp BJ (2004) Enduring effects of prenatal cocaine exposure on selective attention and reactivity to errors: evidence from an animal model. Behav Neurosci 118:290\u2013297","journal-title":"Behav Neurosci"},{"key":"4611_CR34","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/arclin\/acw016","volume":"31","author":"D Gmehlin","year":"2016","unstructured":"Gmehlin D, Fuermaier AB, Walther S, Tucha L, Koerts J, Lange KW, Tucha O, Weisbrod M, Aschenbrenner S (2016) Attentional lapses of adults with attention deficit hyperactivity disorder in tasks of sustained attention. Arch Clin Neuropsychol 31:343\u2013357","journal-title":"Arch Clin Neuropsychol"},{"key":"4611_CR35","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/00005053-200209000-00010","volume":"190","author":"JM Gold","year":"2002","unstructured":"Gold JM, Thaker GK (2002) Current progress in schizophrenia research: cognitive phenotypes of schizophrenia: attention. J Nerv Ment Dis 190:638\u2013639","journal-title":"J Nerv Ment Dis"},{"key":"4611_CR36","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1093\/schbul\/sbu015","volume":"40","author":"BE Gray","year":"2014","unstructured":"Gray BE, Hahn B, Robinson B, Harvey A, Leonard CJ, Luck SJ, Gold JM (2014) Relationships between divided attention and working memory impairment in people with schizophrenia. Schizophr Bull 40:1462\u20131471","journal-title":"Schizophr Bull"},{"key":"4611_CR37","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.bbr.2006.02.002","volume":"169","author":"B Greco","year":"2006","unstructured":"Greco B, Carli M (2006) Reduced attention and increased impulsivity in mice lacking NPY Y2 receptors: relation to anxiolytic-like phenotype. Behav Brain Res 169:325\u2013334","journal-title":"Behav Brain Res"},{"key":"4611_CR38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.schres.2004.09.009","volume":"72","author":"MF Green","year":"2004","unstructured":"Green MF, Kern RS, Heaton RK (2004) Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS. Schizophr Res 72:41\u201351","journal-title":"Schizophr Res"},{"key":"4611_CR39","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1001\/archpsyc.1990.01810140071010","volume":"47","author":"C Grillon","year":"1990","unstructured":"Grillon C, Courchesne E, Ameli R, Geyer MA, Braff DL (1990) Increased distractibility in schizophrenic patients. Electrophysiologic and behavioral evidence. Arch Gen Psychiatry 47:171\u2013179","journal-title":"Arch Gen Psychiatry"},{"key":"4611_CR40","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0165-1781(01)00250-5","volume":"102","author":"A Gut-Fayand","year":"2001","unstructured":"Gut-Fayand A, Dervaux A, Olie JP, Loo H, Poirier MF, Krebs MO (2001) Substance abuse and suicidality in schizophrenia: a common risk factor linked to impulsivity. Psychiatry Res 102:65\u201372","journal-title":"Psychiatry Res"},{"key":"4611_CR41","doi-asserted-by":"crossref","unstructured":"Hahn B, Harvey AN, Gold JM, Fischer BA, Keller WR, Ross TJ, Stein EA (2016) Hyperdeactivation of the default mode network in people with schizophrenia when focusing attention in space. Schizophr Bull 28","DOI":"10.1093\/schbul\/sbw019"},{"key":"4611_CR42","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1037\/a0023938","volume":"121","author":"B Hahn","year":"2012","unstructured":"Hahn B, Robinson BM, Harvey AN, Kaiser ST, Leonard CJ, Luck SJ, Gold JM (2012) Visuospatial attention in schizophrenia: deficits in broad monitoring. J Abnorm Psychol 121:119\u2013128","journal-title":"J Abnorm Psychol"},{"key":"4611_CR43","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.neuroimage.2006.04.177","volume":"32","author":"B Hahn","year":"2006","unstructured":"Hahn B, Ross TJ, Stein EA (2006) Neuroanatomical dissociation between bottom-up and top-down processes of visuospatial selective attention. NeuroImage 32:842\u2013853","journal-title":"NeuroImage"},{"key":"4611_CR44","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00213-002-1005-6","volume":"162","author":"B Hahn","year":"2002","unstructured":"Hahn B, Shoaib M, Stolerman IP (2002) Nicotine-induced enhancement of attention in the five-choice serial reaction time task: the influence of task demands. Psychopharmacology 162:129\u2013137","journal-title":"Psychopharmacology"},{"key":"4611_CR45","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S0893-133X(02)00348-2","volume":"27","author":"B Hahn","year":"2002","unstructured":"Hahn B, Stolerman IP (2002) Nicotine-induced attentional enhancement in rats: effects of chronic exposure to nicotine. Neuropsychopharmacology 27:712\u2013722","journal-title":"Neuropsychopharmacology"},{"key":"4611_CR46","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s002130050410","volume":"133","author":"AA Harrison","year":"1997","unstructured":"Harrison AA, Everitt BJ, Robbins TW (1997) Central 5-HT depletion enhances impulsive responding without affecting the accuracy of attentional performance: interactions with dopaminergic mechanisms. Psychopharmacology 133:329\u2013342","journal-title":"Psychopharmacology"},{"key":"4611_CR47","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1001\/archpsyc.58.1.24","volume":"58","author":"RK Heaton","year":"2001","unstructured":"Heaton RK, Gladsjo JA, Palmer BW, Kuck J, Marcotte TD, Jeste DV (2001) Stability and course of neuropsychological deficits in schizophrenia. Arch Gen Psychiatry 58:24\u201332","journal-title":"Arch Gen Psychiatry"},{"key":"4611_CR48","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1126\/science.308.5728.1574","volume":"308","author":"C Holden","year":"2005","unstructured":"Holden C (2005) Sex and the suffering brain. Science 308:1574\u20131574","journal-title":"Science"},{"key":"4611_CR49","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0006-3223(02)01311-2","volume":"52","author":"MJ Hoptman","year":"2002","unstructured":"Hoptman MJ, Volavka J, Johnson G, Weiss E, Bilder RM, Lim KO (2002) Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: a preliminary study. Biol Psychiatry 52:9\u201314","journal-title":"Biol Psychiatry"},{"key":"4611_CR50","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1046\/j.1460-9568.1999.00701.x","volume":"11","author":"T Humby","year":"1999","unstructured":"Humby T, Laird FM, Davies W, Wilkinson LS (1999) Visuospatial attentional functioning in mice: interactions between cholinergic manipulations and genotype. Eur J Neurosci 11:2813\u20132823","journal-title":"Eur J Neurosci"},{"key":"4611_CR51","doi-asserted-by":"publisher","unstructured":"Ilott NE, Schneider T, Mill J, Schalkwyk L, Brolese G, Bizarro L, Stolerman IP, Dempster E, Asherson P (2014) Long-term effects of gestational nicotine exposure and food-restriction on gene expression in the striatum of adolescent rats. PLoS One 9(2):e88896. doi:\n10.1371\/journal.pone.0088896","DOI":"10.1371\/journal.pone.0088896"},{"key":"4611_CR52","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0166-4328(01)00181-4","volume":"123","author":"WL Inglis","year":"2001","unstructured":"Inglis WL, Olmstead MC, Robbins TW (2001) Selective deficits in attentional performance on the 5-choice serial reaction time task following pedunculopontine tegmental nucleus lesions. Behav Brain Res 123:117\u2013131","journal-title":"Behav Brain Res"},{"key":"4611_CR53","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/adb.12119","volume":"20","author":"C Irimia","year":"2015","unstructured":"Irimia C, Wiskerke J, Natividad LA, Polis IY, de Vries TJ, Pattij T, Parsons LH (2015) Increased impulsivity in rats as a result of repeated cycles of alcohol intoxication and abstinence. Addict Biol 20:263\u2013274","journal-title":"Addict Biol"},{"key":"4611_CR54","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1037\/0735-7044.117.1.76","volume":"117","author":"JD Jentsch","year":"2003","unstructured":"Jentsch JD, Taylor JR (2003) Sex-related differences in spatial divided attention and motor impulsivity in rats. Behav Neurosci 117:76\u201383","journal-title":"Behav Neurosci"},{"key":"4611_CR55","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.bcp.2010.12.028","volume":"81","author":"JF Keeler","year":"2011","unstructured":"Keeler JF, Robbins TW (2011) Translating cognition from animals to humans. Biochem Pharmacol 81:1356\u20131366","journal-title":"Biochem Pharmacol"},{"key":"4611_CR56","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s11920-002-0072-z","volume":"4","author":"LC Klein","year":"2002","unstructured":"Klein LC, Corwin EJ (2002) Seeing the unexpected: how sex differences in stress responses may provide a new perspective on the manifestation of psychiatric disorders. Current Psychiatry Reports 4:441\u2013448","journal-title":"Current Psychiatry Reports"},{"key":"4611_CR57","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/dev.20543","volume":"53","author":"WA Koss","year":"2011","unstructured":"Koss WA, Franklin AD, Juraska JM (2011) Delayed alternation in adolescent and adult male and female rats. Dev Psychobiol 53:724\u2013731","journal-title":"Dev Psychobiol"},{"key":"4611_CR58","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1038\/sj.npp.1300208","volume":"28","author":"G Le Pen","year":"2003","unstructured":"Le Pen G, Grottick AJ, Higgins GA, Moreau JL (2003) Phencyclidine exacerbates attentional deficits in a neurodevelopmental rat model of schizophrenia. Neuropsychopharmacology 28:1799\u20131809","journal-title":"Neuropsychopharmacology"},{"key":"4611_CR59","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pnpbp.2013.04.008","volume":"45","author":"TY Lee","year":"2013","unstructured":"Lee TY, Kim SN, Jang JH, Shim G, Jung WH, Shin NY, Kwon JS (2013) Neural correlate of impulsivity in subjects at ultra-high risk for psychosis. Prog Neuro-Psychopharmacol Biol Psychiatry 45:165\u2013169","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"4611_CR60","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1046\/j.1460-9568.2003.02745.x","volume":"18","author":"O Lehmann","year":"2003","unstructured":"Lehmann O, Grottick AJ, Cassel JC, Higgins GA (2003) A double dissociation between serial reaction time and radial maze performance in rats subjected to 192 IgG-saporin lesions of the nucleus basalis and\/or the septal region. Eur J Neurosci 18:651\u2013666","journal-title":"Eur J Neurosci"},{"key":"4611_CR61","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3109\/00016489109138418","volume":"111","author":"HS Li","year":"1991","unstructured":"Li HS, Borg E (1991) Age-related loss of auditory sensitivity in two mouse genotypes. Acta Otolaryngol 111:827\u2013834","journal-title":"Acta Otolaryngol"},{"key":"4611_CR62","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/schbul\/sbr065","volume":"38","author":"SJ Luck","year":"2012","unstructured":"Luck SJ, Ford JM, Sarter M, Lustig C (2012) CNTRICS final biomarker selection: control of attention. Schizophr Bull 38:53\u201361","journal-title":"Schizophr Bull"},{"key":"4611_CR63","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/BF02246109","volume":"117","author":"J McGaughy","year":"1995","unstructured":"McGaughy J, Sarter M (1995) Behavioral vigilance in rats: task validation and effects of age, amphetamine, and benzodiazepine receptor ligands. Psychopharmacology 117:340\u2013357","journal-title":"Psychopharmacology"},{"key":"4611_CR64","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00406-013-0445-9","volume":"264","author":"T Melcher","year":"2014","unstructured":"Melcher T, Wolter S, Falck S, Wild E, Wild F, Gruber E, Falkai P, Gruber O (2014) Common and disease-specific dysfunctions of brain systems underlying attentional and executive control in schizophrenia and bipolar disorder. Eur Arch Psychiatry Clin Neurosci 264:517\u2013532","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"4611_CR65","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrd3628","volume":"11","author":"MJ Millan","year":"2012","unstructured":"Millan MJ, Agid Y, Brune M, Bullmore ET, Carter CS, Clayton NS, Connor R, Davis S, Deakin B, DeRubeis RJ, Dubois B, Geyer MA, Goodwin GM, Gorwood P, Jay TM, Joels M, Mansuy IM, Meyer-Lindenberg A, Murphy D, Rolls E, Saletu B, Spedding M, Sweeney J, Whittington M, Young LJ (2012) Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov 11:141\u2013168","journal-title":"Nat Rev Drug Discov"},{"key":"4611_CR66","first-page":"375","volume-title":"The use of psychoactive drugs as a neuropsychological tool in studies of attention in man. Drugs and behavior","author":"A Mirsky","year":"1960","unstructured":"Mirsky A, Rosvold H (1960) The use of psychoactive drugs as a neuropsychological tool in studies of attention in man. Drugs and behavior. Wiley, New York, pp 375\u2013392"},{"key":"4611_CR67","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1037\/0735-7044.120.6.1367","volume":"120","author":"J Moon","year":"2006","unstructured":"Moon J, Beaudin AE, Verosky S, Driscoll LL, Weiskopf M, Levitsky DA, Crnic LS, Strupp BJ (2006) Attentional dysfunction, impulsivity, and resistance to change in a mouse model of fragile X syndrome. Behav Neurosci 120:1367\u20131379","journal-title":"Behav Neurosci"},{"key":"4611_CR68","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/cercor\/6.3.470","volume":"6","author":"JL Muir","year":"1996","unstructured":"Muir JL, Everitt BJ, Robbins TW (1996) The cerebral cortex of the rat and visual attentional function: dissociable effects of mediofrontal, cingulate, anterior dorsolateral, and parietal cortex lesions on a five-choice serial reaction time task. Cereb Cortex 6:470\u2013481","journal-title":"Cereb Cortex"},{"key":"4611_CR69","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00213-004-2068-3","volume":"179","author":"ER Murphy","year":"2005","unstructured":"Murphy ER, Dalley JW, Robbins TW (2005) Local glutamate receptor antagonism in the rat prefrontal cortex disrupts response inhibition in a visuospatial attentional task. Psychopharmacology 179:99\u2013107","journal-title":"Psychopharmacology"},{"key":"4611_CR70","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pnpbp.2007.06.017","volume":"32","author":"R Navarra","year":"2008","unstructured":"Navarra R, Graf R, Huang Y, Logue S, Comery T, Hughes Z, Day M (2008) Effects of atomoxetine and methylphenidate on attention and impulsivity in the 5-choice serial reaction time test. Prog Neuro-Psychopharmacol Biol Psychiatry 32:34\u201341","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"4611_CR71","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/nn.2647","volume":"13","author":"EJ Nestler","year":"2010","unstructured":"Nestler EJ, Hyman SE (2010) Animal models of neuropsychiatric disorders. Nat Neurosci 13:1161\u20131169","journal-title":"Nat Neurosci"},{"key":"4611_CR72","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1176\/appi.ajp.2007.07010042","volume":"165","author":"KH Nuechterlein","year":"2008","unstructured":"Nuechterlein KH, Green MF, Kern RS, Baade LE, Barch DM, Cohen JD, Essock S, Fenton WS, Frese FJ 3rd, Gold JM, Goldberg T, Heaton RK, Keefe RS, Kraemer H, Mesholam-Gately R, Seidman LJ, Stover E, Weinberger DR, Young AS, Zalcman S, Marder SR (2008) The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity. Am J Psychiatry 165:203\u2013213","journal-title":"Am J Psychiatry"},{"key":"4611_CR73","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/schbul\/sbn158","volume":"35","author":"KH Nuechterlein","year":"2009","unstructured":"Nuechterlein KH, Luck SJ, Lustig C, Sarter M (2009) CNTRICS final task selection: control of attention. Schizophr Bull 35:182\u2013196","journal-title":"Schizophr Bull"},{"key":"4611_CR74","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1037\/0021-843X.87.2.212","volume":"87","author":"TF Oltmanns","year":"1978","unstructured":"Oltmanns TF (1978) Selective attention in schizophrenic and manic psychoses: the effect of distraction on information processing. J Abnorm Psychol 87:212\u2013225","journal-title":"J Abnorm Psychol"},{"key":"4611_CR75","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1037\/h0076721","volume":"84","author":"TF Oltmanns","year":"1975","unstructured":"Oltmanns TF, Neale JM (1975) Schizophrenic performance when distractors are present: attentional deficit or differential task difficulty? J Abnorm Psychol 84:205\u2013209","journal-title":"J Abnorm Psychol"},{"key":"4611_CR76","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.avb.2012.11.014","volume":"18","author":"M Ouzir","year":"2013","unstructured":"Ouzir M (2013) Impulsivity in schizophrenia: a comprehensive update. Aggress Violent Behav 18:247\u2013254","journal-title":"Aggress Violent Behav"},{"key":"4611_CR77","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.neuropharm.2009.01.004","volume":"56","author":"TA Paine","year":"2009","unstructured":"Paine TA, Carlezon WA Jr (2009) Effects of antipsychotic drugs on MK-801-induced attentional and motivational deficits in rats. Neuropharmacology 56:788\u2013797","journal-title":"Neuropharmacology"},{"key":"4611_CR78","doi-asserted-by":"crossref","first-page":"20160","DOI":"10.1073\/pnas.1214397109","volume":"109","author":"F Papaleo","year":"2012","unstructured":"Papaleo F, Erickson L, Liu G, Chen J, Weinberger DR (2012) Effects of sex and COMT genotype on environmentally modulated cognitive control in mice. Proc Natl Acad Sci U S A 109:20160\u201320165","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4611_CR79","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbr.2006.02.019","volume":"170","author":"S Patel","year":"2006","unstructured":"Patel S, Stolerman IP, Asherson P, Sluyter F (2006) Attentional performance of C57BL\/6 and DBA\/2 mice in the 5-choice serial reaction time task. Behav Brain Res 170:197\u2013203","journal-title":"Behav Brain Res"},{"key":"4611_CR80","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/npp.2013.218","volume":"39","author":"LF Reddy","year":"2014","unstructured":"Reddy LF, Lee J, Davis MC, Altshuler L, Glahn DC, Miklowitz DJ, Green MF (2014) Impulsivity and risk taking in bipolar disorder and schizophrenia. Neuropsychopharmacology 39:456\u2013463","journal-title":"Neuropsychopharmacology"},{"key":"4611_CR81","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00213-002-1154-7","volume":"163","author":"TW Robbins","year":"2002","unstructured":"Robbins TW (2002) The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology 163:362\u2013380","journal-title":"Psychopharmacology"},{"key":"4611_CR82","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.tics.2011.11.009","volume":"16","author":"TW Robbins","year":"2012","unstructured":"Robbins TW, Gillan CM, Smith DG, de Wit S, Ersche KD (2012) Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry. Trends Cogn Sci 16:81\u201391","journal-title":"Trends Cogn Sci"},{"key":"4611_CR83","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1093\/cercor\/bhu053","volume":"25","author":"S Sannino","year":"2015","unstructured":"Sannino S, Gozzi A, Cerasa A, Piras F, Scheggia D, Manago F, Damiano M, Galbusera A, Erickson LC, De Pietri TD, Bifone A, Tsaftaris SA, Caltagirone C, Weinberger DR, Spalletta G, Papaleo F (2015) COMT genetic reduction produces sexually divergent effects on cortical anatomy and working memory in mice and humans. Cereb Cortex 25:2529\u20132541","journal-title":"Cereb Cortex"},{"key":"4611_CR84","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0926-6410(96)00018-3","volume":"3","author":"M Sarter","year":"1996","unstructured":"Sarter M, Bruno JP, Givens B, Moore H, McGaughy J, McMahon K (1996) Neuronal mechanisms mediating drug-induced cognition enhancement: cognitive activity as a necessary intervening variable. Brain Res Cogn Brain Res 3:329\u2013343","journal-title":"Brain Res Cogn Brain Res"},{"key":"4611_CR85","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0193-953X(02)00084-9","volume":"26","author":"T Sharma","year":"2003","unstructured":"Sharma T, Antonova L (2003) Cognitive function in schizophrenia. Deficits, functional consequences, and future treatment. Psychiatr Clin North Am 26:25\u201340","journal-title":"Psychiatr Clin North Am"},{"key":"4611_CR86","doi-asserted-by":"publisher","unstructured":"Smid HG, Martens S, de Witte MR, Bruggeman R (2013) Inflexible minds: impaired attention switching in recent-onset schizophrenia. PLoS One 8(10):e78062. doi:\n10.1371\/journal.pone.0078062","DOI":"10.1371\/journal.pone.0078062"},{"key":"4611_CR87","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.bbr.2011.08.025","volume":"225","author":"M St Peters","year":"2011","unstructured":"St Peters M, Cherian AK, Bradshaw M, Sarter M (2011) Sustained attention in mice: expanding the translational utility of the SAT by incorporating the Michigan Controlled Access Response Port (MICARP). Behav Brain Res 225:574\u2013583","journal-title":"Behav Brain Res"},{"key":"4611_CR88","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1289\/ehp.9263","volume":"115","author":"DE Stangle","year":"2007","unstructured":"Stangle DE, Smith DR, Beaudin SA, Strawderman MS, Levitsky DA, Strupp BJ (2007) Succimer chelation improves learning, attention, and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure. Environ Health Perspect 115:201\u2013209","journal-title":"Environ Health Perspect"},{"key":"4611_CR89","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pnpbp.2013.06.018","volume":"46","author":"A Sumich","year":"2013","unstructured":"Sumich A, Castro A, Anilkumar AP, Zachariah E, Kumari V (2013) Neurophysiological correlates of excitement in schizophrenia. Prog Neuro-Psychopharmacol Biol Psychiatry 46:132\u2013138","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"4611_CR90","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.biopsych.2013.05.013","volume":"75","author":"V Voon","year":"2014","unstructured":"Voon V, Irvine MA, Derbyshire K, Worbe Y, Lange I, Abbott S, Morein-Zamir S, Dudley R, Caprioli D, Harrison NA, Wood J, Dalley JW, Bullmore ET, Grant JE, Robbins TW (2014) Measuring \u201cwaiting\u201d impulsivity in substance addictions and binge eating disorder in a novel analogue of rodent serial reaction time task. Biol Psychiatry 75:148\u2013155","journal-title":"Biol Psychiatry"},{"key":"4611_CR91","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/978-3-211-73574-9_38","volume":"72","author":"S Walitza","year":"2007","unstructured":"Walitza S, Melfsen S, Herhaus G, Scheuerpflug P, Warnke A, Muller T, Lange KW, Gerlach M (2007) Association of Parkinson\u2019s disease with symptoms of attention deficit hyperactivity disorder in childhood. J Neural Transm Suppl 72:311\u2013315","journal-title":"J Neural Transm Suppl"},{"key":"4611_CR92","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/WCO.0b013e32835ee548","volume":"26","author":"DM Werling","year":"2013","unstructured":"Werling DM, Geschwind DH (2013) Sex differences in autism spectrum disorders. Curr Opin Neurol 26:146\u2013153","journal-title":"Curr Opin Neurol"},{"key":"4611_CR93","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0165-3806(95)00188-3","volume":"91","author":"JF Willott","year":"1996","unstructured":"Willott JF, Bross LS (1996) Morphological changes in the anteroventral cochlear nucleus that accompany sensorineural hearing loss in DBA\/2J and C57BL\/6J mice. Brain Res Dev Brain Res 91:218\u2013226","journal-title":"Brain Res Dev Brain Res"},{"key":"4611_CR94","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.pbb.2006.03.003","volume":"83","author":"CC Wrenn","year":"2006","unstructured":"Wrenn CC, Turchi JN, Schlosser S, Dreiling JL, Stephenson DA, Crawley JN (2006) Performance of galanin transgenic mice in the 5-choice serial reaction time attentional task. Pharmacol Biochem Behav 83:428\u2013440","journal-title":"Pharmacol Biochem Behav"},{"key":"4611_CR95","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/j.neubiorev.2012.10.002","volume":"37","author":"JW Young","year":"2013","unstructured":"Young JW, Jentsch JD, Bussey TJ, Wallace TL, Hutcheson DM (2013) Consideration of species differences in developing novel molecules as cognition enhancers. Neurosci Biobehav Rev 37:2181\u20132193","journal-title":"Neurosci Biobehav Rev"},{"key":"4611_CR96","doi-asserted-by":"publisher","unstructured":"Zvyagintsev M, Parisi C, Chechko N, Nikolaev AR, Mathiak K (2013) Attention and multisensory integration of emotions in schizophrenia. Front Hum Neurosci 7:674. doi:\n10.3389\/fnhum.2013.00674","DOI":"10.3389\/fnhum.2013.00674"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-017-4611-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-017-4611-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-017-4611-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,13]],"date-time":"2017-06-13T05:08:15Z","timestamp":1497330495000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-017-4611-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,5]]},"references-count":96,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["4611"],"URL":"https:\/\/doi.org\/10.1007\/s00213-017-4611-z","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,5]]}}}