{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:06:31Z","timestamp":1760425591019},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:00:00Z","timestamp":1511913600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s00213-017-4784-5","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T03:08:02Z","timestamp":1511924882000},"page":"681-693","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Change and dispersion of QT interval during treatment with quetiapine extended release versus aripiprazole in children and adolescents with first-episode psychosis: results from the TEA trial"],"prefix":"10.1007","volume":"235","author":[{"given":"Karsten Gjessing","family":"Jensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"G\u00e4rtner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph U.","family":"Correll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ditte","family":"Rud\u00e5","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dea Gowers","family":"Klauber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Stentebjerg-Olesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte","family":"Fagerlund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens Richardt","family":"Jepsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Fink-Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Juul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Katrine","family":"Pagsberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"4784_CR1","unstructured":"Alders M, Christiaans I (1993) Long QT syndrome. In: Pagon RA et al. (eds) GeneReviews(R). Seattle (WA),"},{"issue":"16","key":"4784_CR2","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1001\/jama.289.16.2120","volume":"289","author":"SM Al-Khatib","year":"2003","unstructured":"Al-Khatib SM, LaPointe NM, Kramer JM, Califf RM (2003) What clinicians should know about the QT interval. JAMA 289(16):2120\u20132127. https:\/\/doi.org\/10.1001\/jama.289.16.2120","journal-title":"JAMA"},{"key":"4784_CR3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2174\/157488610789869265","volume":"5","author":"PA Alvarez","year":"2010","unstructured":"Alvarez PA, Pahissa J (2010) QT alterations in psychopharmacology: proven candidates and suspects. Curr Drug Saf 5:97\u2013104","journal-title":"Curr Drug Saf"},{"key":"4784_CR4","first-page":"353","volume":"7","author":"H Bazett","year":"1920","unstructured":"Bazett H (1920) An analysis of the time-relations of electrocardiograms. Heart 7:353\u2013370","journal-title":"Heart"},{"issue":"1","key":"4784_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.psym.2012.11.001","volume":"54","author":"SR Beach","year":"2013","unstructured":"Beach SR, Celano CM, Noseworthy PA, Januzzi JL, Huffman JC (2013) QTc prolongation, torsades de pointes, and psychotropic medications. Psychosomatics 54(1):1\u201313. https:\/\/doi.org\/10.1016\/j.psym.2012.11.001","journal-title":"Psychosomatics"},{"issue":"7","key":"4784_CR6","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1007\/s00702-004-0153-8","volume":"111","author":"J Blair","year":"2004","unstructured":"Blair J, Taggart B, Martin A (2004) Electrocardiographic safety profile and monitoring guidelines in pediatric psychopharmacology. J Neural Transm 111(7):791\u2013815. https:\/\/doi.org\/10.1007\/s00702-004-0153-8","journal-title":"J Neural Transm"},{"issue":"Suppl 2","key":"4784_CR7","doi-asserted-by":"publisher","first-page":"S12","DOI":"10.1016\/S0924-9338(10)71701-6","volume":"25","author":"CU Correll","year":"2010","unstructured":"Correll CU (2010) From receptor pharmacology to improved outcomes: individualising the selection, dosing, and switching of antipsychotics. Eur Psychiatrty 25(Suppl 2):S12\u2013S21. https:\/\/doi.org\/10.1016\/S0924-9338(10)71701-6","journal-title":"Eur Psychiatrty"},{"issue":"16","key":"4784_CR8","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1001\/jama.2009.1549","volume":"302","author":"CU Correll","year":"2009","unstructured":"Correll CU, Manu P, Olshanskiy V, Napolitano B, Kane JM, Malhotra AK (2009) Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents. JAMA 302(16):1765\u20131773. https:\/\/doi.org\/10.1001\/jama.2009.1549","journal-title":"JAMA"},{"issue":"06","key":"4784_CR9","doi-asserted-by":"publisher","first-page":"854","DOI":"10.4088\/JCP.10m05990yel","volume":"72","author":"CU Correll","year":"2011","unstructured":"Correll CU, Lops JD, Figen V, Malhotra AK, Kane JM, Manu P (2011) QT interval duration and dispersion in children and adolescents treated with ziprasidone. J Clinl Psychiatry 72(06):854\u2013860. https:\/\/doi.org\/10.4088\/JCP.10m05990yel","journal-title":"J Clinl Psychiatry"},{"issue":"2","key":"4784_CR10","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2174\/1573403X12666160301120217","volume":"12","author":"LX Cubeddu","year":"2016","unstructured":"Cubeddu LX (2016) Drug-induced inhibition and trafficking disruption of ion channels: pathogenesis of QT abnormalities and drug-induced fatal arrhythmias. Curr Cardiol Rev 12(2):141\u2013154. https:\/\/doi.org\/10.2174\/1573403X12666160301120217","journal-title":"Curr Cardiol Rev"},{"key":"4784_CR11","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1046\/j.1365-2125.2003.01791.x","volume":"55","author":"M Desai","year":"2003","unstructured":"Desai M, Li L, Desta Z, Malik M, Flockhart D (2003) Variability of heart rate correction methods for the QT interval. Br J Clin Pharmacol 55:511\u2013517","journal-title":"Br J Clin Pharmacol"},{"key":"4784_CR12","first-page":"40","volume":"19","author":"D Elbe","year":"2010","unstructured":"Elbe D, Savage R (2010) How does this happen? Part I: mechanisms of adverse drug reactions associated with psychotropic medications. J Can Acad Child Adolesc Psychiatry 19:40\u201345","journal-title":"J Can Acad Child Adolesc Psychiatry"},{"key":"4784_CR13","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.euroneuro.2010.07.002","volume":"21","author":"D Fraguas","year":"2011","unstructured":"Fraguas D, Correll CU, Merchan-Naranjo J, Rapado-Castro M, Parellada M, Moreno C, Arango C (2011) Efficacy and safety of second-generation antipsychotics in children and adolescents with psychotic and bipolar spectrum disorders: comprehensive review of prospective head-to-head and placebo-controlled comparisons. Eur Neuropsychopharmacol 21:621\u2013645","journal-title":"Eur Neuropsychopharmacol"},{"key":"4784_CR14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.0954-6820.1920.tb18267.x","volume":"53","author":"L Fridericia","year":"1920","unstructured":"Fridericia L (1920) The duration of systole in the electrocardiogram of normal subjects and of patients with heart disease. Acta Med Scand 53:17","journal-title":"Acta Med Scand"},{"key":"4784_CR15","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.pnpbp.2013.10.020","volume":"51","author":"E Germano","year":"2014","unstructured":"Germano E et al (2014) ECG parameters in children and adolescents treated with aripiprazole and risperidone. Prog Neuro-Psychopharmacol Biol Psychiatry 51:23\u201327. https:\/\/doi.org\/10.1016\/j.pnpbp.2013.10.020","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"3","key":"4784_CR16","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/j.1540-8167.2006.00408.x","volume":"17","author":"I Goldenberg","year":"2006","unstructured":"Goldenberg I, Moss AJ, Zareba W (2006) QT interval: how to measure it and what is \u201cnormal\u201d. J Cardiovasc Electrophysiol 17(3):333\u2013336. https:\/\/doi.org\/10.1111\/j.1540-8167.2006.00408.x","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"3","key":"4784_CR17","doi-asserted-by":"publisher","first-page":"109","DOI":"10.4103\/2229-3485.83221","volume":"2","author":"SK Gupta","year":"2011","unstructured":"Gupta SK (2011) Intention-to-treat concept: a review. Perspect Clin Res 2(3):109\u2013112. https:\/\/doi.org\/10.4103\/2229-3485.83221","journal-title":"Perspect Clin Res"},{"issue":"11","key":"4784_CR18","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.2165\/00003495-200262110-00006","volume":"62","author":"PM Haddad","year":"2002","unstructured":"Haddad PM, Anderson IM (2002) Antipsychotic-related QTc prolongation, torsade de pointes and sudden death. Drugs 62(11):1649\u20131671. https:\/\/doi.org\/10.2165\/00003495-200262110-00006","journal-title":"Drugs"},{"key":"4784_CR19","doi-asserted-by":"crossref","unstructured":"Halfdanarson O et al. (2017) International trends in antipsychotic use: a study in 16 countries, 2005\u20132014 Eur Neuropsychopharmacol","DOI":"10.1016\/j.euroneuro.2017.07.001"},{"key":"4784_CR20","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.ahj.2005.02.007","volume":"150","author":"CH Hennekens","year":"2005","unstructured":"Hennekens CH, Hennekens AR, Hollar D, Casey DE (2005) Schizophrenia and increased risks of cardiovascular disease. Am Heart J 150:1115\u20131121","journal-title":"Am Heart J"},{"issue":"6","key":"4784_CR21","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1136\/hrt.71.6.508","volume":"71","author":"PD Higham","year":"1994","unstructured":"Higham PD, Campbell RW (1994) QT dispersion. Br Heart J 71(6):508\u2013510. https:\/\/doi.org\/10.1136\/hrt.71.6.508","journal-title":"Br Heart J"},{"key":"4784_CR22","first-page":"3","volume":"3","author":"M Hodges","year":"1997","unstructured":"Hodges M (1997) Rate correction of the QT interval. Card Electrophysiol Rev 3:3","journal-title":"Card Electrophysiol Rev"},{"issue":"1","key":"4784_CR23","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jaac.2014.10.002","volume":"54","author":"KG Jensen","year":"2015","unstructured":"Jensen KG, Juul K, Fink-Jensen A, Correll CU, Pagsberg AK (2015) Corrected QT changes during antipsychotic treatment of children and adolescents: a systematic review and meta-analysis of clinical trials. J Am Acad Child Adolesc Psychiatry 54(1):25\u201336. https:\/\/doi.org\/10.1016\/j.jaac.2014.10.002","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"4784_CR24","doi-asserted-by":"publisher","unstructured":"Jensen KG, Correll CU, Rud\u00e5 D, Klauber DG, Stentebjerg-Olesen M, Fagerlund B, Jepsen JRM, Fink-Jensen A, Pagsberg AK (2017) Pretreatment cardiometabolic status in youth with early-onset psychosis: baseline results from the TEA trial. J Clin Psychiatry 78(8):e1035\u2013e1046. https:\/\/doi.org\/10.4088\/JCP.15m10479","DOI":"10.4088\/JCP.15m10479"},{"issue":"7","key":"4784_CR25","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1097\/00004583-199707000-00021","volume":"36","author":"J Kaufman","year":"1997","unstructured":"Kaufman J et al (1997) Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36(7):980\u2013988. https:\/\/doi.org\/10.1097\/00004583-199707000-00021","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"2","key":"4784_CR26","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","volume":"13","author":"SR Kay","year":"1987","unstructured":"Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13(2):261\u2013276. https:\/\/doi.org\/10.1093\/schbul\/13.2.261","journal-title":"Schizophr Bull"},{"issue":"1","key":"4784_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0014-2999(02)02074-5","volume":"450","author":"S Kongsamut","year":"2002","unstructured":"Kongsamut S, Kang J, Chen XL, Roehr J, Rampe D (2002) A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs. Eur J Pharmacol 450(1):37\u201341. https:\/\/doi.org\/10.1016\/S0014-2999(02)02074-5","journal-title":"Eur J Pharmacol"},{"issue":"9896","key":"4784_CR28","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/S0140-6736(13)60733-3","volume":"382","author":"S Leucht","year":"2013","unstructured":"Leucht S, Cipriani A, Spineli L, Mavridis D, \u00d6rey D, Richter F, Samara M, Barbui C, Engel RR, Geddes JR, Kissling W, Stapf MP, L\u00e4ssig B, Salanti G, Davis JM (2013) Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet (Lond, Engl) 382(9896):951\u2013962. https:\/\/doi.org\/10.1016\/S0140-6736(13)60733-3","journal-title":"Lancet (Lond, Engl)"},{"key":"4784_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0447.1987.tb10566.x","volume":"334","author":"O Lingjaerde","year":"1987","unstructured":"Lingjaerde O, Ahlfors UG, Bech P, Dencker SJ, Elgen K (1987) The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatr Scand Suppl 334:1\u2013100","journal-title":"Acta Psychiatr Scand Suppl"},{"key":"4784_CR30","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1111\/j.1540-8159.1996.tb03191.x","volume":"19","author":"M Malik","year":"1996","unstructured":"Malik M (1996) If Dr. Bazett had had a computer .... Pace 19:1635\u20131639","journal-title":"Pace"},{"issue":"2-3","key":"4784_CR31","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0920-9964(03)00050-1","volume":"61","author":"SR Marder","year":"2003","unstructured":"Marder SR, McQuade RD, Stock E, Kaplita S, Marcus R, Safferman AZ, Saha A, Ali M, Iwamoto T (2003) Aripiprazole in the treatment of schizophrenia: safety and tolerability in short-term, placebo-controlled trials. Schizophr Res 61(2-3):123\u2013136. https:\/\/doi.org\/10.1016\/S0920-9964(03)00050-1","journal-title":"Schizophr Res"},{"key":"4784_CR32","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/09540260500071798","volume":"17","author":"J Meyer","year":"2005","unstructured":"Meyer J, Koro CE, L\u2019Italien GJ (2005) The metabolic syndrome and schizophrenia: a review. Int Rev Psychiatry 17:173\u2013180","journal-title":"Int Rev Psychiatry"},{"key":"4784_CR33","doi-asserted-by":"crossref","unstructured":"Michels G, Kochanek M, Pfister R (2015) Life-threatening cardiac arrhythmias due to drug-induced QT prolongation: a retrospective study over 6\u00a0years from a medical intensive care unit Med Klin Intensivmed Notfmed","DOI":"10.1007\/s00063-015-0071-6"},{"issue":"1 Suppl","key":"4784_CR34","first-page":"I140","volume":"85","author":"AJ Moss","year":"1992","unstructured":"Moss AJ, Robinson J (1992) Clinical features of the idiopathic long QT syndrome. Circulation 85(1 Suppl):I140\u2013I144","journal-title":"Circulation"},{"issue":"2","key":"4784_CR35","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1089\/cap.2007.0061","volume":"17","author":"E Nahshoni","year":"2007","unstructured":"Nahshoni E, Spitzer S, Berant M, Shoval G, Zalsman G, Weizman A (2007) QT interval and dispersion in very young children treated with antipsychotic drugs: a retrospective chart review. J child adolesc psychopharmacol 17(2):187\u2013194. https:\/\/doi.org\/10.1089\/cap.2007.0061","journal-title":"J child adolesc psychopharmacol"},{"issue":"1","key":"4784_CR36","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/sj.mp.4002066","volume":"13","author":"HA Nasrallah","year":"2008","unstructured":"Nasrallah HA (2008) Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles. Mol Psychiatry 13(1):27\u201335. https:\/\/doi.org\/10.1038\/sj.mp.4002066","journal-title":"Mol Psychiatry"},{"issue":"2","key":"4784_CR37","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1R387","volume":"47","author":"S Nelson","year":"2013","unstructured":"Nelson S, Leung JG (2013) Torsades de pointes after administration of low-dose aripiprazole. Ann Pharmacother 47(2):e11. https:\/\/doi.org\/10.1345\/aph.1R387","journal-title":"Ann Pharmacother"},{"issue":"6","key":"4784_CR38","doi-asserted-by":"publisher","first-page":"473","DOI":"10.2165\/11587800-000000000-00000","volume":"25","author":"J Nielsen","year":"2011","unstructured":"Nielsen J, Graff C, Kanters JK, Toft E, Taylor D, Meyer JM (2011) Assessing QT interval prolongation and its associated risks with antipsychotics. CNS Drugs 25(6):473\u2013490. https:\/\/doi.org\/10.2165\/11587800-000000000-00000","journal-title":"CNS Drugs"},{"issue":"1","key":"4784_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055176","volume":"8","author":"M Nordentoft","year":"2013","unstructured":"Nordentoft M, Wahlbeck K, H\u00e4llgren J, Westman J, \u00d6sby U, Alinaghizadeh H, Gissler M, Laursen TM (2013) Excess mortality, causes of death and life expectancy in 270,770 patients with recent onset of mental disorders in Denmark, Finland and Sweden. PLoS One 8(1):e55176. https:\/\/doi.org\/10.1371\/journal.pone.0055176","journal-title":"PLoS One"},{"issue":"1","key":"4784_CR40","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1161\/01.CIR.101.1.61","volume":"101","author":"PM Okin","year":"2000","unstructured":"Okin PM, Devereux RB, Howard BV, Fabsitz RR, Lee ET, Welty TK (2000) Assessment of QT interval and QT dispersion for prediction of all-cause and cardiovascular mortality in American Indians: the Strong Heart Study. Circulation 101(1):61\u201366. https:\/\/doi.org\/10.1161\/01.CIR.101.1.61","journal-title":"Circulation"},{"key":"4784_CR41","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1001\/archgenpsychiatry.2012.647","volume":"69","author":"M Olfson","year":"2012","unstructured":"Olfson M, Blanco C, Liu SM, Wang S, Correll CU (2012) National trends in the office-based treatment of children, adolescents, and adults with antipsychotics. Arch Gen Psychiatry 69:1247\u20131256","journal-title":"Arch Gen Psychiatry"},{"key":"4784_CR42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0920-9964(99)00191-7","volume":"45","author":"U Osby","year":"2000","unstructured":"Osby U, Correia N, Brandt L, Ekbom A, Sparen P (2000) Mortality and causes of death in schizophrenia in Stockholm county. Sweden Schizophr Res 45:21\u201328","journal-title":"Sweden Schizophr Res"},{"issue":"1","key":"4784_CR43","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/1471-244X-14-199","volume":"14","author":"AK Pagsberg","year":"2014","unstructured":"Pagsberg AK, Jeppesen P, Klauber DG, Jensen KG, Rud\u00e5 D, Stentebjerg-Olesen M, Jantzen P, Rasmussen S, Saldeen EAS, Lauritsen MBG, Bilenberg N, Stenstr\u00f8m AD, Pedersen J, Nyvang L, Madsen S, Lauritsen MB, Vernal DL, Thomsen PH, Paludan J, Werge TM, Winge K, Juul K, Gluud C, Skoog M, Wetterslev J, Jepsen JRM, Correll CU, Fink-Jensen A, Fagerlund B (2014) Quetiapine versus aripiprazole in children and adolescents with psychosis\u2014protocol for the randomised, blinded clinical Tolerability and Efficacy of Antipsychotics (TEA) trial. BMC Psychiatry 14(1):199. https:\/\/doi.org\/10.1186\/1471-244X-14-199","journal-title":"BMC Psychiatry"},{"issue":"8","key":"4784_CR44","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/S2215-0366(17)30166-9","volume":"4","author":"AK Pagsberg","year":"2017","unstructured":"Pagsberg AK, Jeppesen P, Klauber DG, Jensen KG, Rud\u00e5 D, Stentebjerg-Olesen M, Jantzen P, Rasmussen S, Saldeen EAS, Lauritsen MBG, Bilenberg N, Stenstr\u00f8m AD, Nyvang L, Madsen S, Werge TM, Lange T, Gluud C, Skoog M, Winkel P, Jepsen JRM, Fagerlund B, Correll CU, Fink-Jensen A (2017) Quetiapine extended release versus aripiprazole in children and adolescents with first-episode psychosis: the multicentre, double-blind, randomised tolerability and efficacy of antipsychotics (TEA) trial. Lancet Psychiatry 4(8):605\u2013618. https:\/\/doi.org\/10.1016\/S2215-0366(17)30166-9","journal-title":"Lancet Psychiatry"},{"key":"4784_CR45","first-page":"124","volume":"19","author":"C Panagiotopoulos","year":"2010","unstructured":"Panagiotopoulos C, Ronsley R, Elbe D, Davidson J, Smith DH (2010) First do no harm: promoting an evidence-based approach to atypical antipsychotic use in children and adolescents. J Can Acad Child Adolesc Psychiatry 19:124\u2013137","journal-title":"J Can Acad Child Adolesc Psychiatry"},{"issue":"6","key":"4784_CR46","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1097\/CRD.0b013e3181c07592","volume":"17","author":"U Patel","year":"2009","unstructured":"Patel U, Pavri BB (2009) Short QT syndrome: a review. Cardiol Rev 17(6):300\u2013303. https:\/\/doi.org\/10.1097\/CRD.0b013e3181c07592","journal-title":"Cardiol Rev"},{"key":"4784_CR47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.schres.2009.03.025","volume":"111","author":"JK Patel","year":"2009","unstructured":"Patel JK, Buckley PF, Woolson S, Hamer RM, McEvoy JP, Perkins DO, Lieberman JA (2009) Metabolic profiles of second-generation antipsychotics in early psychosis: findings from the CAFE study. Schizophr Res 111:9\u201316","journal-title":"Schizophr Res"},{"issue":"18","key":"4784_CR48","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1007\/s00213-015-4024-9","volume":"232","author":"C Polcwiartek","year":"2015","unstructured":"Polcwiartek C, Sneider B, Graff C, Taylor D, Meyer J, Kanters JK, Nielsen J (2015) The cardiac safety of aripiprazole treatment in patients at high risk for torsade: a systematic review with a meta-analytic approach. Psychopharmacology 232(18):3297\u20133308. https:\/\/doi.org\/10.1007\/s00213-015-4024-9","journal-title":"Psychopharmacology"},{"key":"4784_CR49","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/MED.0b013e32833de61c","volume":"17","author":"P Pramyothin","year":"2010","unstructured":"Pramyothin P, Khaodhiar L (2010) Metabolic syndrome with the atypical antipsychotics. Curr Opin Endocrinol Diabetes Obes 17:460\u2013466","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"4784_CR50","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/YCO.0b013e32833f46c9","volume":"23","author":"TJ Raedler","year":"2010","unstructured":"Raedler TJ (2010) Cardiovascular aspects of antipsychotics. Curr Opin Psychiatry 23:574\u2013581","journal-title":"Curr Opin Psychiatry"},{"issue":"10","key":"4784_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164309","volume":"11","author":"S Sasaoka","year":"2016","unstructured":"Sasaoka S, Matsui T, Hane Y, Abe J, Ueda N, Motooka Y, Hatahira H, Fukuda A, Naganuma M, Hasegawa S, Kinosada Y, Nakamura M (2016) Time-to-onset analysis of drug-induced long QT syndrome based on a spontaneous reporting system for adverse drug events. PLoS One 11(10):e0164309. https:\/\/doi.org\/10.1371\/journal.pone.0164309","journal-title":"PLoS One"},{"issue":"1","key":"4784_CR52","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jelectrocard.2004.09.001","volume":"38","author":"RR Shah","year":"2005","unstructured":"Shah RR (2005) Drug-induced QT dispersion: does it predict the risk of torsade de pointes? J Electrocardiol 38(1):10\u201318. https:\/\/doi.org\/10.1016\/j.jelectrocard.2004.09.001","journal-title":"J Electrocardiol"},{"issue":"3","key":"4784_CR53","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/j.1600-0447.2008.01334.x","volume":"119","author":"SM Stahl","year":"2009","unstructured":"Stahl SM, Mignon L, Meyer JM (2009) Which comes first: atypical antipsychotic treatment or cardiometabolic risk? Acta Psychiatr Scand 119(3):171\u2013179. https:\/\/doi.org\/10.1111\/j.1600-0447.2008.01334.x","journal-title":"Acta Psychiatr Scand"},{"issue":"3","key":"4784_CR54","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s11845-013-0925-y","volume":"182","author":"M Stuhec","year":"2013","unstructured":"Stuhec M, Svab V (2013) Atomoxetine-induced life-threatening long QT syndrome. Ir J Med Sci 182(3):535\u2013537. https:\/\/doi.org\/10.1007\/s11845-013-0925-y","journal-title":"Ir J Med Sci"},{"issue":"2","key":"4784_CR55","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1034\/j.1600-0447.2003.02078.x","volume":"107","author":"DM Taylor","year":"2003","unstructured":"Taylor DM (2003) Antipsychotics and QT prolongation. Acta Psychiatr Scand 107(2):85\u201395. https:\/\/doi.org\/10.1034\/j.1600-0447.2003.02078.x","journal-title":"Acta Psychiatr Scand"},{"issue":"18","key":"4784_CR56","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.2174\/138161206777585102","volume":"12","author":"D Thomas","year":"2006","unstructured":"Thomas D, Karle CA, Kiehn J (2006) The cardiac hERG\/IKr potassium channel as pharmacological target: structure, function, regulation, and clinical applications. Curr Pharm Des 12(18):2271\u20132283. https:\/\/doi.org\/10.2174\/138161206777585102","journal-title":"Curr Pharm Des"},{"issue":"1","key":"4784_CR57","doi-asserted-by":"publisher","first-page":"35","DOI":"10.2165\/00002018-200528010-00003","volume":"28","author":"K Titier","year":"2005","unstructured":"Titier K, Girodet PO, Verdoux H, Molimard M, B\u00e9gaud B, Haverkamp W, Lader M, Moore N (2005) Atypical antipsychotics: from potassium channels to torsade de pointes and sudden death. Drug Saf 28(1):35\u201351. https:\/\/doi.org\/10.2165\/00002018-200528010-00003","journal-title":"Drug Saf"},{"issue":"6","key":"4784_CR58","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1017\/S1047951100005588","volume":"9","author":"E Vialle","year":"1999","unstructured":"Vialle E, Albalkhi R, Zimmerman M, Friedli B (1999) Normal values of signal-averaged electrocardiographic parameters and QT dispersion in infants and children. Cardiol Young 9(6):556\u2013561","journal-title":"Cardiol Young"},{"issue":"12","key":"4784_CR59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163619","volume":"11","author":"J Vicente","year":"2016","unstructured":"Vicente J, Johannesen L, Hosseini M, Mason JW, Sager PT, Pueyo E, Strauss DG (2016) Electrocardiographic biomarkers for detection of drug-induced late sodium current block. PLoS One 11(12):e0163619. https:\/\/doi.org\/10.1371\/journal.pone.0163619","journal-title":"PLoS One"},{"issue":"1","key":"4784_CR60","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1046\/j.1540-8167.2005.03520.x","volume":"16","author":"JF Wernicke","year":"2005","unstructured":"Wernicke JF, Faries D, Breitung R, Girod D (2005) QT correction methods in children and adolescents. J Cardiovasc Electrophysiol 16(1):76\u201381. https:\/\/doi.org\/10.1046\/j.1540-8167.2005.03520.x","journal-title":"J Cardiovasc Electrophysiol"},{"key":"4784_CR61","unstructured":"WHO (1992) ICD-10: the ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. World Health Organization"},{"issue":"Suppl","key":"4784_CR62","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1054\/jelc.2001.28863","volume":"34","author":"W Zareba","year":"2001","unstructured":"Zareba W, Moss AJ (2001) Long QT syndrome in children. J Electrocardiol 34(Suppl):167\u2013171","journal-title":"J Electrocardiol"},{"key":"4784_CR63","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1399-5448.2007.00271.x","volume":"8","author":"P Zimmet","year":"2007","unstructured":"Zimmet P et al (2007) The metabolic syndrome in children and adolescents\u2014an IDF consensus report. Pediatr Diabetes 8:299\u2013306","journal-title":"Pediatr Diabetes"},{"key":"4784_CR64","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00399-012-0232-8","volume":"23","author":"S Zumhagen","year":"2012","unstructured":"Zumhagen S, Stallmeyer B, Friedrich C, Eckardt L, Seebohm G, Schulze-Bahr E (2012) Inherited long QT syndrome: clinical manifestation, genetic diagnostics, and therapy. Herzschrittmacherther Elektrophysiol 23:211\u2013219","journal-title":"Herzschrittmacherther Elektrophysiol"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-017-4784-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-017-4784-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-017-4784-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T05:29:28Z","timestamp":1719638968000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-017-4784-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,29]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["4784"],"URL":"https:\/\/doi.org\/10.1007\/s00213-017-4784-5","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,29]]}}}