{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:00:14Z","timestamp":1790650814198,"version":"4.1.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s00213-018-4835-6","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T16:10:05Z","timestamp":1517501405000},"page":"1191-1198","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Brain-derived neurotrophic factor as a biomarker for cognitive recovery in acute schizophrenia: 12-week results from a prospective longitudinal study"],"prefix":"10.1007","volume":"235","author":[{"given":"Yi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4071-1627","authenticated-orcid":false,"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,1]]},"reference":[{"key":"4835_CR1","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1177\/1073858410395147","volume":"18","author":"F Adriano","year":"2012","unstructured":"Adriano F, Caltagirone C, Spalletta G (2012) Hippocampal volume reduction in first-episode and chronic schizophrenia: a review and meta-analysis. Neuroscientist 18:180\u2013200","journal-title":"Neuroscientist"},{"key":"4835_CR2","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/sj.mp.4001637","volume":"10","author":"F Angelucci","year":"2005","unstructured":"Angelucci F, Brene S, Mathe AA (2005) BDNF in schizophrenia, depression and corresponding animal models. Mol Psychiatry 10:345\u2013352","journal-title":"Mol Psychiatry"},{"key":"4835_CR3","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/jnr.10440","volume":"71","author":"O Bai","year":"2003","unstructured":"Bai O, Chlan-Fourney J, Bowen R, Keegan D, Li XM (2003) Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs. J Neurosci Res 71:127\u2013131","journal-title":"J Neurosci Res"},{"issue":"3-4","key":"4835_CR4","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1515\/REVNEURO.2007.18.3-4.253","volume":"18","author":"T Bast","year":"2007","unstructured":"Bast T (2007) Toward an integrative perspective on hippocampal function: from the rapid encoding of experience to adaptive behavior. Rev Neurosci 18(3-4):253\u2013281","journal-title":"Rev Neurosci"},{"issue":"3","key":"4835_CR5","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.conb.2011.01.003","volume":"21","author":"T Bast","year":"2011","unstructured":"Bast T (2011) The hippocampal learning-behavior translation and the functional significance of hippocampal dysfunction in schizophrenia. Curr Opin Neurobiol 21(3):492\u2013501. \n                    https:\/\/doi.org\/10.1016\/j.conb.2011.01.003","journal-title":"Curr Opin Neurobiol"},{"issue":"5","key":"4835_CR6","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1093\/schbul\/sbu198","volume":"41","author":"E Bora","year":"2015","unstructured":"Bora E, Pantelis C (2015) Meta-analysis of cognitive impairment in first-episode bipolar disorder: comparison with first-episode schizophrenia and healthy controls. Schizophr Bull 41(5):1095\u20131104. \n                    https:\/\/doi.org\/10.1093\/schbul\/sbu198","journal-title":"Schizophr Bull"},{"key":"4835_CR7","first-page":"1247","volume":"11","author":"J Cai","year":"2015","unstructured":"Cai J, Zhu Y, Zhang W, Wang Y, Zhang C (2015) Comprehensive family therapy: an effective approach for cognitive rehabilitation in schizophrenia. Neuropsychiatr Dis Treat 11:1247\u20131253","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"8","key":"4835_CR8","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1176\/appi.ajp.2011.10081209","volume":"168","author":"RE Carrion","year":"2011","unstructured":"Carrion RE, Goldberg TE, McLaughlin D, Auther AM, Correll CU, Cornblatt BA (2011) Impact of neurocognition on social and role functioning in individuals at clinical high risk for psychosis. Am J Psychiatry 168(8):806\u2013813. \n                    https:\/\/doi.org\/10.1176\/appi.ajp.2011.10081209","journal-title":"Am J Psychiatry"},{"issue":"9","key":"4835_CR9","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1101\/lm.025304.111","volume":"19","author":"DA Caruana","year":"2012","unstructured":"Caruana DA, Alexander GM, Dudek SM (2012) New insights into the regulation of synaptic plasticity from an unexpected place: hippocampal area CA2. Learn Mem 19(9):391\u2013400. \n                    https:\/\/doi.org\/10.1101\/lm.025304.111","journal-title":"Learn Mem"},{"issue":"09","key":"4835_CR10","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1017\/S0033291712002838","volume":"43","author":"WC Chang","year":"2013","unstructured":"Chang WC, Hui CLM, Tang JYM, Wong GHY, Chan SKW, Lee EHM, Chen EYH (2013) Impacts of duration of untreated psychosis on cognition and negative symptoms in first-episode schizophrenia: a 3-year prospective follow-up study. Psychol Med 43(09):1883\u20131893. \n                    https:\/\/doi.org\/10.1017\/S0033291712002838","journal-title":"Psychol Med"},{"issue":"15","key":"4835_CR11","first-page":"2752","volume":"125","author":"XS Chen","year":"2012","unstructured":"Chen XS, Zhang C, Xu YF, Zhang MD, Lou FY, Chen C, Tang J (2012) Neonatal ventral hippocampal lesion as a valid model of schizophrenia: evidence from sensory gating study. Chin Med J 125(15):2752\u20132754","journal-title":"Chin Med J"},{"issue":"5","key":"4835_CR12","doi-asserted-by":"publisher","first-page":"850","DOI":"10.5114\/aoms.2011.25561","volume":"7","author":"Y Cheng","year":"2011","unstructured":"Cheng Y, Wu W, Wang J, Feng W, Wu X, Li C (2011) Reliability and validity of the repeatable battery for the assessment of neuropsychological status in community-dwelling elderly. Arch Med Sci 7(5):850\u2013857. \n                    https:\/\/doi.org\/10.5114\/aoms.2011.25561","journal-title":"Arch Med Sci"},{"issue":"3","key":"4835_CR13","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.apnu.2014.01.003","volume":"28","author":"J Dang","year":"2014","unstructured":"Dang J, Zhang J, Guo Z, Lu W, Cai J, Shi Z, Zhang C (2014) A pilot study of iPad-assisted cognitive training for schizophrenia. Arch Psychiatr Nurs 28(3):197\u2013199. \n                    https:\/\/doi.org\/10.1016\/j.apnu.2014.01.003","journal-title":"Arch Psychiatr Nurs"},{"issue":"3","key":"4835_CR14","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1093\/schbul\/sbn187","volume":"35","author":"SH Fatemi","year":"2009","unstructured":"Fatemi SH, Folsom TD (2009) The neurodevelopmental hypothesis of schizophrenia, revisited. Schizophr Bull 35(3):528\u2013548. \n                    https:\/\/doi.org\/10.1093\/schbul\/sbn187","journal-title":"Schizophr Bull"},{"issue":"Suppl 2","key":"4835_CR15","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1016\/0924-977X(96)00010-7","volume":"6","author":"B Gallhofer","year":"1996","unstructured":"Gallhofer B, Bauer U, Lis S, Krieger S, Gruppe H (1996) Cognitive dysfunction in schizophrenia: comparison of treatment with atypical antipsychotic agents and conventional neuroleptic drugs. Eur Neuropsychopharmacol 6(Suppl 2):S13\u2013S20","journal-title":"Eur Neuropsychopharmacol"},{"issue":"9","key":"4835_CR16","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1038\/mp.2010.88","volume":"16","author":"MJ Green","year":"2011","unstructured":"Green MJ, Matheson SL, Shepherd A, Weickert CS, Carr VJ (2011) Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis. Mol Psychiatry 16(9):960\u2013972. \n                    https:\/\/doi.org\/10.1038\/mp.2010.88","journal-title":"Mol Psychiatry"},{"issue":"4","key":"4835_CR17","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1080\/13803390802251386","volume":"31","author":"PD Harvey","year":"2009","unstructured":"Harvey PD, Keefe RSE, Patterson TL, Heaton RK, Bowie CR (2009) Abbreviated neuropsychological assessment in schizophrenia: prediction of different aspects of outcome. J Clin Exp Neuropsychol 31(4):462\u2013471. \n                    https:\/\/doi.org\/10.1080\/13803390802251386","journal-title":"J Clin Exp Neuropsychol"},{"key":"4835_CR18","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.pscychresns.2017.03.014","volume":"263","author":"SV Kalmady","year":"2017","unstructured":"Kalmady SV, Shivakumar V, Arasappa R, Subramaniam A, Gautham S, Venkatasubramanian G, Gangadhar BN (2017) Clinical correlates of hippocampus volume and shape in antipsychotic-naive schizophrenia. Psychiatry Res 263:93\u2013102","journal-title":"Psychiatry Res"},{"key":"4835_CR19","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","volume":"13","author":"SR Kay","year":"1987","unstructured":"Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13:261\u2013276","journal-title":"Schizophr Bull"},{"key":"4835_CR20","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1097\/JCP.0b013e3181855cd6","volume":"28","author":"MI Krakowski","year":"2008","unstructured":"Krakowski MI, Czobor P, Nolan KA (2008) Atypical antipsychotics, neurocognitive deficits, and aggression in schizophrenic patients. J Clin Psychopharmacol 28:485\u2013493","journal-title":"J Clin Psychopharmacol"},{"issue":"1","key":"4835_CR21","doi-asserted-by":"publisher","first-page":"CR44","DOI":"10.12659\/MSM.882202","volume":"18","author":"K Kucharska-Pietura","year":"2012","unstructured":"Kucharska-Pietura K, Tylec A, Czernikiewicz A, Mortimer A (2012) Attentional and emotional functioning in schizophrenia patients treated with conventional and atypical antipsychotic drugs. Med Sci Monit 18(1):CR44\u2013CR49","journal-title":"Med Sci Monit"},{"issue":"5","key":"4835_CR22","first-page":"580","volume":"9","author":"SD Kuipers","year":"2006","unstructured":"Kuipers SD, Bramham CR (2006) Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapy. Curr Opin Drug Discov Dev 9(5):580\u2013586","journal-title":"Curr Opin Drug Discov Dev"},{"key":"4835_CR23","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.neuropharm.2013.04.005","volume":"76 Pt C","author":"G Leal","year":"2014","unstructured":"Leal G, Comprido D, Duarte CB (2014) BDNF-induced local protein synthesis and synaptic plasticity. Neuropharmacology 76 Pt C:639\u2013656","journal-title":"Neuropharmacology"},{"key":"4835_CR24","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.brainres.2014.10.019","volume":"1621","author":"G Leal","year":"2015","unstructured":"Leal G, Afonso PM, Salazar IL, Duarte CB (2015) Regulation of hippocampal synaptic plasticity by BDNF. Brain Res 1621:82\u2013101. \n                    https:\/\/doi.org\/10.1016\/j.brainres.2014.10.019","journal-title":"Brain Res"},{"issue":"8","key":"4835_CR25","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1097\/NMD.0000000000000463","volume":"204","author":"J Lee","year":"2016","unstructured":"Lee J, Nurjono M, Lee TS (2016) Levels of serum brain-derived neurotrophic factor in schizophrenia. J Nerv Ment Dis 204(8):636\u2013639. \n                    https:\/\/doi.org\/10.1097\/NMD.0000000000000463","journal-title":"J Nerv Ment Dis"},{"issue":"5","key":"4835_CR26","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.biopsych.2013.07.026","volume":"75","author":"TA Lett","year":"2014","unstructured":"Lett TA, Voineskos AN, Kennedy JL, Levine B, Daskalakis ZJ (2014) Treating working memory deficits in schizophrenia: a review of the neurobiology. Biol Psychiatry 75(5):361\u2013370. \n                    https:\/\/doi.org\/10.1016\/j.biopsych.2013.07.026","journal-title":"Biol Psychiatry"},{"issue":"01","key":"4835_CR27","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1192\/bjp.bp.113.134064","volume":"205","author":"ZZ Li","year":"2014","unstructured":"Li ZZ, Zhang C, Fan JB, Yuan CM, Huang J, Chen J, Yi ZH, Wang ZW, Hong W, Wang Y, Lu WH, Guan YT, Wu ZG, Su YS, Cao L, Hu YY, Hao Y, Liu MY, Yu SY, Cui DH, Xu L, Song YY, Fang YR (2014) Brain-derived neurotrophic factor levels and bipolar disorder in patients in their first depressive episode: 3-year prospective longitudinal study. Br J Psychiatry 205(01):29\u201335. \n                    https:\/\/doi.org\/10.1192\/bjp.bp.113.134064","journal-title":"Br J Psychiatry"},{"issue":"3","key":"4835_CR28","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s12031-012-9750-4","volume":"47","author":"WH Lu","year":"2012","unstructured":"Lu WH, Zhang C, Yi ZH, Li ZZ, Wu ZG, Fang YR (2012) Association between BDNF Val66Met polymorphism and cognitive performance in antipsychotic-naive patients with schizophrenia. J Mol Neurosci 47(3):505\u2013510. \n                    https:\/\/doi.org\/10.1007\/s12031-012-9750-4","journal-title":"J Mol Neurosci"},{"issue":"3","key":"4835_CR29","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.pbb.2011.02.009","volume":"98","author":"O Mutlu","year":"2011","unstructured":"Mutlu O, Ulak G, Celikyurt IK, Akar FY, Erden F (2011) Effects of olanzapine, sertindole and clozapine on learning and memory in the Morris water maze test in naive and MK-801-treated mice. Pharmacol Biochem Behav 98(3):398\u2013404. \n                    https:\/\/doi.org\/10.1016\/j.pbb.2011.02.009","journal-title":"Pharmacol Biochem Behav"},{"issue":"4","key":"4835_CR30","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.neures.2011.08.010","volume":"71","author":"SW Park","year":"2011","unstructured":"Park SW, Phuong VT, Lee CH, Lee JG, Seo MK, Cho HY, Fang ZH, Lee BJ, Kim YH (2011) Effects of antipsychotic drugs on BDNF, GSK-3beta, and beta-catenin expression in rats subjected to immobilization stress. Neurosci Res 71(4):335\u2013340. \n                    https:\/\/doi.org\/10.1016\/j.neures.2011.08.010","journal-title":"Neurosci Res"},{"issue":"1-2","key":"4835_CR31","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jneuroim.2009.11.010","volume":"219","author":"PJ Pistell","year":"2010","unstructured":"Pistell PJ, Morrison CD, Gupta S, Knight AG, Keller JN, Ingram DK, Bruce-Keller AJ (2010) Cognitive impairment following high fat diet consumption is associated with brain inflammation. J Neuroimmunol 219(1-2):25\u201332. \n                    https:\/\/doi.org\/10.1016\/j.jneuroim.2009.11.010","journal-title":"J Neuroimmunol"},{"issue":"1","key":"4835_CR32","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/35049004","volume":"2","author":"MM Poo","year":"2001","unstructured":"Poo MM (2001) Neurotrophins as synaptic modulators. Nat Rev Neurosci 2(1):24\u201332. \n                    https:\/\/doi.org\/10.1038\/35049004","journal-title":"Nat Rev Neurosci"},{"key":"4835_CR33","first-page":"1206","volume":"22","author":"XY Qin","year":"2017","unstructured":"Qin XY, Wu HT, Cao C, Loh YP, Cheng Y (2017) A meta-analysis of peripheral blood nerve growth factor levels in patients with schizophrenia. Mol Psychiatry 22:1206\u20131212","journal-title":"Mol Psychiatry"},{"issue":"3","key":"4835_CR34","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1076\/jcen.20.3.310.823","volume":"20","author":"C Randolph","year":"1998","unstructured":"Randolph C, Tierney MC, Mohr E, Chase TN (1998) The repeatable battery for the assessment of neuropsychological status (RBANS): preliminary clinical validity. J Clin Exp Neuropsychol 20(3):310\u2013319. \n                    https:\/\/doi.org\/10.1076\/jcen.20.3.310.823","journal-title":"J Clin Exp Neuropsychol"},{"issue":"4","key":"4835_CR35","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.yfrne.2006.09.004","volume":"27","author":"HE Scharfman","year":"2006","unstructured":"Scharfman HE, MacLusky NJ (2006) Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: complexity of steroid hormone-growth factor interactions in the adult CNS. Front Neuroendocrinol 27(4):415\u2013435. \n                    https:\/\/doi.org\/10.1016\/j.yfrne.2006.09.004","journal-title":"Front Neuroendocrinol"},{"key":"4835_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuropharm.2016.11.012","volume":"114","author":"WS Song","year":"2017","unstructured":"Song WS, Cha JH, Yoon SH, Cho YS, Park KY, Kim MH (2017) The atypical antipsychotic olanzapine disturbs depotentiation by modulating mAChRs and impairs reversal learning. Neuropharmacology 114:1\u201311. \n                    https:\/\/doi.org\/10.1016\/j.neuropharm.2016.11.012","journal-title":"Neuropharmacology"},{"key":"4835_CR37","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.neuroimage.2014.05.057","volume":"99","author":"K Subramaniam","year":"2014","unstructured":"Subramaniam K, Luks TL, Garrett C, Chung C, Fisher M, Nagarajan S, Vinogradov S (2014) Intensive cognitive training in schizophrenia enhances working memory and associated prefrontal cortical efficiency in a manner that drives long-term functional gains. NeuroImage 99:281\u2013292. \n                    https:\/\/doi.org\/10.1016\/j.neuroimage.2014.05.057","journal-title":"NeuroImage"},{"issue":"02","key":"4835_CR38","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1017\/S1355617709090225","volume":"15","author":"RJ Thoma","year":"2009","unstructured":"Thoma RJ, Monnig M, Hanlon FM, Miller GA, Petropoulos H, Mayer AR, Yeo R, Euler M, Lysne P, Moses SN, Canive JM (2009) Hippocampus volume and episodic memory in schizophrenia. J Int Neuropsychol Soc 15(02):182\u2013195. \n                    https:\/\/doi.org\/10.1017\/S1355617709090225","journal-title":"J Int Neuropsychol Soc"},{"issue":"4","key":"4835_CR39","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s12017-011-8159-5","volume":"13","author":"A Tsai","year":"2011","unstructured":"Tsai A, Liou YJ, Hong CJ, Wu CL, Tsai SJ, Bai YM (2011) Association study of brain-derived neurotrophic factor gene polymorphisms and body weight change in schizophrenic patients under long-term atypical antipsychotic treatment. NeuroMolecular Med 13(4):328\u2013333. \n                    https:\/\/doi.org\/10.1007\/s12017-011-8159-5","journal-title":"NeuroMolecular Med"},{"issue":"3","key":"4835_CR40","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/wps.20252","volume":"14","author":"D Vancampfort","year":"2015","unstructured":"Vancampfort D, Stubbs B, Mitchell AJ, De Hert M, Wampers M, Ward PB, Rosenbaum S, Correll CU (2015) Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta-analysis. World Psychiatry 14(3):339\u2013347. \n                    https:\/\/doi.org\/10.1002\/wps.20252","journal-title":"World Psychiatry"},{"issue":"6","key":"4835_CR41","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.biopsych.2009.02.017","volume":"66","author":"S Vinogradov","year":"2009","unstructured":"Vinogradov S, Fisher M, Holland C, Shelly W, Wolkowitz O, Mellon SH (2009) Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia? Biol Psychiatry 66(6):549\u2013553. \n                    https:\/\/doi.org\/10.1016\/j.biopsych.2009.02.017","journal-title":"Biol Psychiatry"},{"issue":"1-3","key":"4835_CR42","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.schres.2012.12.021","volume":"144","author":"CH Wang","year":"2013","unstructured":"Wang CH, Li Y, Yang J, Su LY, Geng YG, Li H, Wang JK, Mu JL (2013) A randomized controlled trial of olanzapine improving memory deficits in Han Chinese patients with first-episode schizophrenia. Schizophr Res 144(1-3):129\u2013135. \n                    https:\/\/doi.org\/10.1016\/j.schres.2012.12.021","journal-title":"Schizophr Res"},{"key":"4835_CR43","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.2147\/NDT.S118160","volume":"12","author":"P Wang","year":"2016","unstructured":"Wang P, Cai J, Ni J, Zhang J, Tang W, Zhang C (2016) The NCAN gene: schizophrenia susceptibility and cognitive dysfunction. Neuropsychiatr Dis Treat 12:2875\u20132883. \n                    https:\/\/doi.org\/10.2147\/NDT.S118160","journal-title":"Neuropsychiatr Dis Treat"},{"key":"4835_CR44","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.brainres.2011.08.037","volume":"1417","author":"Z Yi","year":"2011","unstructured":"Yi Z, Zhang C, Wu Z, Hong W, Li Z, Fang Y, Yu S (2011) Lack of effect of brain derived neurotrophic factor (BDNF) Val66Met polymorphism on early onset schizophrenia in Chinese Han population. Brain Res 1417:146\u2013150. \n                    https:\/\/doi.org\/10.1016\/j.brainres.2011.08.037","journal-title":"Brain Res"},{"issue":"8","key":"4835_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042676","volume":"7","author":"T Yoshida","year":"2012","unstructured":"Yoshida T, Ishikawa M, Niitsu T, Nakazato M, Watanabe H, Shiraishi T, Shiina A, Hashimoto T, Kanahara N, Hasegawa T, Enohara M, Kimura A, Iyo M, Hashimoto K (2012) Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder. PLoS One 7(8):e42676. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0042676","journal-title":"PLoS One"},{"issue":"1","key":"4835_CR46","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.pnpbp.2012.05.014","volume":"39","author":"GC Zai","year":"2012","unstructured":"Zai GC, Zai CC, Chowdhury NI, Tiwari AK, Souza RP, Lieberman JA, Meltzer HY, Potkin SG, Muller DJ, Kennedy JL (2012) The role of brain-derived neurotrophic factor (BDNF) gene variants in antipsychotic response and antipsychotic-induced weight gain. Prog Neuro-Psychopharmacol Biol Psychiatry 39(1):96\u2013101. \n                    https:\/\/doi.org\/10.1016\/j.pnpbp.2012.05.014","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"12","key":"4835_CR47","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.jpsychires.2006.08.007","volume":"41","author":"XY Zhang","year":"2007","unstructured":"Zhang XY, Tan YL, Zhou DF, Cao LY, Wu GY, Xu Q, Shen Y, Haile CN, Kosten TA, Kosten TR (2007) Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics. J Psychiatr Res 41(12):997\u20131004. \n                    https:\/\/doi.org\/10.1016\/j.jpsychires.2006.08.007","journal-title":"J Psychiatr Res"},{"issue":"9","key":"4835_CR48","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1038\/sj.npp.1301619","volume":"33","author":"XY Zhang","year":"2008","unstructured":"Zhang XY, Zhou DF, Wu GY, Cao LY, Tan YL, Haile CN, Li J, Lu L, Kosten TA, Kosten TR (2008) BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia. Neuropsychopharmacology 33(9):2200\u20132205. \n                    https:\/\/doi.org\/10.1038\/sj.npp.1301619","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"4835_CR49","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1007\/s12031-010-9458-2","volume":"43","author":"C Zhang","year":"2011","unstructured":"Zhang C, Li Z, Shao Y, Xie B, Du Y, Fang Y, Yu S (2011) Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population. J Mol Neurosci 43(3):406\u2013411. \n                    https:\/\/doi.org\/10.1007\/s12031-010-9458-2","journal-title":"J Mol Neurosci"},{"issue":"2","key":"4835_CR50","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00213-012-2643-y","volume":"222","author":"XY Zhang","year":"2012","unstructured":"Zhang XY, Liang J, Chen DC, Xiu MH, Yang FD, Kosten TA, Kosten TR (2012) Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia. Psychopharmacology 222(2):277\u2013284. \n                    https:\/\/doi.org\/10.1007\/s00213-012-2643-y","journal-title":"Psychopharmacology"},{"issue":"8","key":"4835_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072652","volume":"8","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Chen M, Wu Z, Chen J, Yu S, Fang Y, Zhang C (2013) Association study of Val66Met polymorphism in brain-derived neurotrophic factor gene with clozapine-induced metabolic syndrome: preliminary results. PLoS One 8(8):e72652. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0072652","journal-title":"PLoS One"},{"key":"4835_CR52","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.pnpbp.2013.12.010","volume":"50","author":"C Zhang","year":"2014","unstructured":"Zhang C, Cai J, Zhang JT, Li ZZ, Guo ZW, Zhang X, Lu WH, Zhang Y, Yuan AH, Yu SY, Fang YR (2014a) Genetic modulation of working memory deficits by ankyrin 3 gene in schizophrenia. Prog Neuro-Psychopharmacol Biol Psychiatry 50:110\u2013115. \n                    https:\/\/doi.org\/10.1016\/j.pnpbp.2013.12.010","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"2-3","key":"4835_CR53","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.schres.2014.07.054","volume":"159","author":"C Zhang","year":"2014","unstructured":"Zhang C, Fang YR, Xu L (2014b) Glutamate receptor 1 phosphorylation at serine 845 contributes to the therapeutic effect of olanzapine on schizophrenia-like cognitive impairments. Schizophr Res 159(2-3):376\u2013384. \n                    https:\/\/doi.org\/10.1016\/j.schres.2014.07.054","journal-title":"Schizophr Res"},{"key":"4835_CR54","doi-asserted-by":"publisher","first-page":"e1460","DOI":"10.4088\/JCP.15m10047","volume":"77","author":"C Zhang","year":"2016","unstructured":"Zhang C, Chen MJ, Wu GJ, Wang ZW, Rao SZ, Zhang Y, Yi ZH, Yang WM, Gao KM, Song LS (2016) Effectiveness of antipsychotic drugs for 24-month maintenance treatment in first-episode schizophrenia: evidence from a community-based \"real-world\" study. J Clin Psychiatry 77:e1460\u2013e1466","journal-title":"J Clin Psychiatry"},{"key":"4835_CR55","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.psyneuen.2017.04.014","volume":"81","author":"C Zhang","year":"2017","unstructured":"Zhang C, Fang X, Yao P, Mao Y, Cai J, Zhang Y, Chen M, Fan W, Tang W, Song L (2017) Metabolic adverse effects of olanzapine on cognitive dysfunction: a possible relationship between BDNF and TNF-alpha. Psychoneuroendocrinology 81:138\u2013143. \n                    https:\/\/doi.org\/10.1016\/j.psyneuen.2017.04.014","journal-title":"Psychoneuroendocrinology"},{"issue":"7","key":"4835_CR56","doi-asserted-by":"publisher","first-page":"5573","DOI":"10.1007\/s12035-016-0098-6","volume":"54","author":"G Zhao","year":"2017","unstructured":"Zhao G, Zhang C, Chen J, Su Y, Zhou R, Wang F, Xia W, Huang J, Wang Z, Hu Y, Cao L, Guo X, Yuan C, Wang Y, Yi Z, Lu W, Wu Y, Wu Z, Hong W, Peng D, Fang Y (2017) Ratio of mBDNF to proBDNF for differential diagnosis of major depressive disorder and bipolar depression. Mol Neurobiol 54(7):5573\u20135582. \n                    https:\/\/doi.org\/10.1007\/s12035-016-0098-6","journal-title":"Mol Neurobiol"},{"key":"4835_CR57","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/jhg.2014.94","volume":"60","author":"Y Zhu","year":"2015","unstructured":"Zhu Y, Wang Z, Ni J, Zhang Y, Chen M, Cai J, Li X, Zhang W, Zhang C (2015) Genetic variant in NDUFS1 gene is associated with schizophrenia and negative symptoms in Han Chinese. J Hum Genet 60:11\u201316","journal-title":"J Hum Genet"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-018-4835-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-018-4835-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-018-4835-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T21:25:26Z","timestamp":1548969926000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-018-4835-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,1]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["4835"],"URL":"https:\/\/doi.org\/10.1007\/s00213-018-4835-6","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,1]]},"assertion":[{"value":"11 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}