{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:09:59Z","timestamp":1792782599879,"version":"4.5.0"},"reference-count":221,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T00:00:00Z","timestamp":1521072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stockholm Centre for Psychiatry Research"},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["523-2013-2982"],"award-info":[{"award-number":["523-2013-2982"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Birgitta and Sten Westerberg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1007\/s00213-018-4872-1","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T10:28:25Z","timestamp":1521109705000},"page":"1317-1334","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["The 5-HT1B receptor - a potential target for antidepressant treatment"],"prefix":"10.1007","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8495-8125","authenticated-orcid":false,"given":"Mikael","family":"Tiger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Varn\u00e4s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiro","family":"Okubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Lundberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,15]]},"reference":[{"key":"4872_CR1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1046\/j.1471-4159.2001.00550.x","volume":"79","author":"A Adell","year":"2001","unstructured":"Adell A, Celada P, Artigas F (2001) The role of 5-HT1B receptors in the regulation of serotonin cell firing and release in the rat brain. J Neurochem 79:172\u2013182","journal-title":"J Neurochem"},{"key":"4872_CR2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0026-895X(25)08798-X","volume":"41","author":"N Adham","year":"1992","unstructured":"Adham N, Romanienko P, Hartig P, Weinshank RL, Branchek T (1992) The rat 5-hydroxytryptamine1B receptor is the species homologue of the human 5-hydroxytryptamine1D beta receptor. Mol Pharmacol 41:1\u20137","journal-title":"Mol Pharmacol"},{"key":"4872_CR3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.pharmthera.2006.08.004","volume":"113","author":"KD Alex","year":"2007","unstructured":"Alex KD, Pehek EA (2007) Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol Ther 113:296\u2013320","journal-title":"Pharmacol Ther"},{"key":"4872_CR4","first-page":"131","volume":"33","author":"H Anisman","year":"2008","unstructured":"Anisman H, Du L, Palkovits M, Faludi G, Kovacs GG, Szontagh-Kishazi P, Merali Z, Poulter MO (2008) Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjects. J Psychiatry Neurosci 33:131\u2013141","journal-title":"J Psychiatry Neurosci"},{"key":"4872_CR5","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/1097-4547(20000701)61:1<82::AID-JNR10>3.0.CO;2-E","volume":"61","author":"JP Anthony","year":"2000","unstructured":"Anthony JP, Sexton TJ, Neumaier JF (2000) Antidepressant-induced regulation of 5-HT(1b) mRNA in rat dorsal raphe nucleus reverses rapidly after drug discontinuation. J Neurosci Res 61:82\u201387","journal-title":"J Neurosci Res"},{"key":"4872_CR6","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1023\/A:1007672008297","volume":"25","author":"E Bagdy","year":"2000","unstructured":"Bagdy E, Kiraly I, Harsing LG Jr (2000) Reciprocal innervation between serotonergic and GABAergic neurons in raphe nuclei of the rat. Neurochem Res 25:1465\u20131473","journal-title":"Neurochem Res"},{"key":"4872_CR7","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0028-3908(99)00010-6","volume":"38","author":"NM Barnes","year":"1999","unstructured":"Barnes NM, Sharp T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38:1083\u20131152","journal-title":"Neuropharmacology"},{"key":"4872_CR8","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.physbeh.2007.11.006","volume":"93","author":"AJ Bechtholt","year":"2008","unstructured":"Bechtholt AJ, Smith K, Gaughan S, Lucki I (2008) Sucrose intake and fasting glucose levels in 5-HT(1A) and 5-HT(1B) receptor mutant mice. Physiol Behav 93:659\u2013665","journal-title":"Physiol Behav"},{"key":"4872_CR9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1056\/NEJMra073096","volume":"358","author":"RH Belmaker","year":"2008","unstructured":"Belmaker RH, Agam G (2008) Major depressive disorder. N Engl J Med 358:55\u201368","journal-title":"N Engl J Med"},{"key":"4872_CR10","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s12888-014-0276-x","volume":"14","author":"A Berhan","year":"2014","unstructured":"Berhan A, Barker A (2014) Vortioxetine in the treatment of adult patients with major depressive disorder: a meta-analysis of randomized double-blind controlled trials. BMC Psychiatry 14:276","journal-title":"BMC Psychiatry"},{"key":"4872_CR11","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s002100000357","volume":"363","author":"HJ Bidmon","year":"2001","unstructured":"Bidmon HJ, Schleicher A, Wicke K, Gross G, Zilles K (2001) Localisation of mRNA for h5-HT1B and h5-HT1D receptors in human dorsal raphe. Naunyn Schmiedeberg's Arch Pharmacol 363:364\u2013368","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"4872_CR12","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/BF00168834","volume":"337","author":"P Blier","year":"1988","unstructured":"Blier P, Chaput Y, de Montigny C (1988) Long-term 5-HT reuptake blockade, but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: an electrophysiological study in the rat brain. Naunyn Schmiedeberg's Arch Pharmacol 337:246\u2013254","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"4872_CR13","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0165-6147(94)90315-8","volume":"15","author":"P Blier","year":"1994","unstructured":"Blier P, de Montigny C (1994) Current advances and trends in the treatment of depression. Trends Pharmacol Sci 15:220\u2013226","journal-title":"Trends Pharmacol Sci"},{"key":"4872_CR14","first-page":"225","volume":"5","author":"P Bonaventure","year":"1997","unstructured":"Bonaventure P, Schotte A, Cras P, Leysen JE (1997) Autoradiographic mapping of 5-HT1B- and 5-HT1D receptors in human brain using [3H]alniditan, a new radioligand. Receptors Channels 5:225\u2013230","journal-title":"Receptors Channels"},{"key":"4872_CR15","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0306-4522(97)00302-3","volume":"82","author":"P Bonaventure","year":"1998","unstructured":"Bonaventure P, Voorn P, Luyten WH, Jurzak M, Schotte A, Leysen JE (1998) Detailed mapping of serotonin 5-HT1B and 5-HT1D receptor messenger RNA and ligand binding sites in guinea-pig brain and trigeminal ganglion: clues for function. Neuroscience 82:469\u2013484","journal-title":"Neuroscience"},{"key":"4872_CR16","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0306-4522(94)90164-3","volume":"58","author":"U Boschert","year":"1994","unstructured":"Boschert U, Amara DA, Segu L, Hen R (1994) The mouse 5-hydroxytryptamine1B receptor is localized predominantly on axon terminals. Neuroscience 58:167\u2013182","journal-title":"Neuroscience"},{"key":"4872_CR17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s002130000529","volume":"152","author":"ML Boshuisen","year":"2000","unstructured":"Boshuisen ML, den Boer JA (2000) Zolmitriptan (a 5-HT1B\/1D receptor agonist with central action) does not increase symptoms in obsessive compulsive disorder. Psychopharmacology 152:74\u201379","journal-title":"Psychopharmacology"},{"key":"4872_CR18","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1523\/JNEUROSCI.19-08-03204.1999","volume":"19","author":"B Boutrel","year":"1999","unstructured":"Boutrel B, Franc B, Hen R, Hamon M, Adrien J (1999) Key role of 5-HT1B receptors in the regulation of paradoxical sleep as evidenced in 5-HT1B knock-out mice. J Neurosci 19:3204\u20133212","journal-title":"J Neurosci"},{"key":"4872_CR19","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0006-3223(00)01018-0","volume":"49","author":"JA Bouwknecht","year":"2001","unstructured":"Bouwknecht JA, Hijzen TH, van der Gugten J, Maes RA, Hen R, Olivier B (2001) Absence of 5-HT(1B) receptors is associated with impaired impulse control in male 5-HT(1B) knockout mice. Biol Psychiatry 49:557\u2013568","journal-title":"Biol Psychiatry"},{"key":"4872_CR20","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1152\/jn.00770.2004","volume":"93","author":"JR Bramley","year":"2005","unstructured":"Bramley JR, Sollars PJ, Pickard GE, Dudek FE (2005) 5-HT1B receptor-mediated presynaptic inhibition of GABA release in the suprachiasmatic nucleus. J Neurophysiol 93:3157\u20133164","journal-title":"J Neurophysiol"},{"key":"4872_CR21","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1476-5381.1985.tb09451.x","volume":"86","author":"MP Brazell","year":"1985","unstructured":"Brazell MP, Marsden CA, Nisbet AP, Routledge C (1985) The 5-HT1 receptor agonist RU-24969 decreases 5-hydroxytryptamine (5-HT) release and metabolism in the rat frontal cortex in vitro and in vivo. Br J Pharmacol 86:209\u2013216","journal-title":"Br J Pharmacol"},{"key":"4872_CR22","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0028-3908(94)90067-1","volume":"33","author":"AT Bruinvels","year":"1994","unstructured":"Bruinvels AT, Landwehrmeyer B, Gustafson EL, Durkin MM, Mengod G, Branchek TA, Hoyer D, Palacios JM (1994) Localization of 5-HT1B, 5-HT1D alpha, 5-HT1E and 5-HT1F receptor messenger RNA in rodent and primate brain. Neuropharmacology 33:367\u2013386","journal-title":"Neuropharmacology"},{"key":"4872_CR23","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/BF00166939","volume":"347","author":"AT Bruinvels","year":"1993","unstructured":"Bruinvels AT, Palacios JM, Hoyer D (1993) Autoradiographic characterisation and localisation of 5-HT1D compared to 5-HT1B binding sites in rat brain. Naunyn Schmiedeberg's Arch Pharmacol 347:569\u2013582","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"4872_CR24","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1037\/0735-7044.113.3.587","volume":"113","author":"D Brunner","year":"1999","unstructured":"Brunner D, Buhot MC, Hen R, Hofer M (1999) Anxiety, motor activation, and maternal-infant interactions in 5HT1B knockout mice. Behav Neurosci 113:587\u2013601","journal-title":"Behav Neurosci"},{"key":"4872_CR25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF00168629","volume":"353","author":"M Buhlen","year":"1996","unstructured":"Buhlen M, Fink K, Boing C, Gothert M (1996) Evidence for presynaptic location of inhibitory 5-HT1D beta-like autoreceptors in the guinea-pig brain cortex. Naunyn Schmiedeberg's Arch Pharmacol 353:281\u2013289","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"4872_CR26","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3109\/07853890008998828","volume":"32","author":"MC Buhot","year":"2000","unstructured":"Buhot MC, Martin S, Segu L (2000) Role of serotonin in memory impairment. Ann Med 32:210\u2013221","journal-title":"Ann Med"},{"key":"4872_CR27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0006-8993(95)01092-0","volume":"704","author":"JC Cassel","year":"1995","unstructured":"Cassel JC, Jeltsch H, Neufang B, Lauth D, Szabo B, Jackisch R (1995) Downregulation of muscarinic- and 5-HT1B-mediated modulation of [3H]acetylcholine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts of septal origin. Brain Res 704:153\u2013166","journal-title":"Brain Res"},{"key":"4872_CR28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0091-3057(00)00389-0","volume":"67","author":"N Castanon","year":"2000","unstructured":"Castanon N, Scearce-Levie K, Lucas JJ, Rocha B, Hen R (2000) Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists. Pharmacol Biochem Behav 67:559\u2013566","journal-title":"Pharmacol Biochem Behav"},{"key":"4872_CR29","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s002130050841","volume":"141","author":"F Chaouloff","year":"1999","unstructured":"Chaouloff F, Courvoisier H, Moisan MP, Mormede P (1999) GR 127935 reduces basal locomotor activity and prevents RU 24969-, but not D-amphetamine-induced hyperlocomotion, in the Wistar-Kyoto hyperactive (WKHA) rat. Psychopharmacology 141:326\u2013331","journal-title":"Psychopharmacology"},{"key":"4872_CR30","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/j.1476-5381.1993.tb14010.x","volume":"110","author":"SC Cheetham","year":"1993","unstructured":"Cheetham SC, Heal DJ (1993) Evidence that RU 24969-induced locomotor activity in C57\/B1\/6 mice is specifically mediated by the 5-HT1B receptor. Br J Pharmacol 110:1621\u20131629","journal-title":"Br J Pharmacol"},{"key":"4872_CR31","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.neuroscience.2007.11.003","volume":"151","author":"L Chen","year":"2008","unstructured":"Chen L, Yung KK, Chan YS, Yung WH (2008) 5-HT excites globus pallidus neurons by multiple receptor mechanisms. Neuroscience 151:439\u2013451","journal-title":"Neuroscience"},{"key":"4872_CR32","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1124\/mol.111.071092","volume":"79","author":"L Chen","year":"2011","unstructured":"Chen L, Zhou W, Chen PC, Gaisina I, Yang S, Li X (2011) Glycogen synthase kinase-3beta is a functional modulator of serotonin-1B receptors. Mol Pharmacol 79:974\u2013986","journal-title":"Mol Pharmacol"},{"key":"4872_CR33","first-page":"541","volume":"33","author":"F Chenu","year":"2008","unstructured":"Chenu F, David DJ, Leroux-Nicollet I, Le Maitre E, Gardier AM, Bourin M (2008) Serotonin1B heteroreceptor activation induces an antidepressant-like effect in mice with an alteration of the serotonergic system. J Psychiatry Neurosci 33:541\u2013550","journal-title":"J Psychiatry Neurosci"},{"key":"4872_CR34","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1211\/0022357055399","volume":"57","author":"E Chojnacka-Wojcik","year":"2005","unstructured":"Chojnacka-Wojcik E, Klodzinska A, Tatarczynska E (2005) The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action. J Pharm Pharmacol 57:253\u2013257","journal-title":"J Pharm Pharmacol"},{"key":"4872_CR35","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1523\/JNEUROSCI.22-11-04550.2002","volume":"22","author":"MS Clark","year":"2002","unstructured":"Clark MS, Sexton TJ, McClain M, Root D, Kohen R, Neumaier JF (2002) Overexpression of 5-HT1B receptor in dorsal raphe nucleus using herpes simplex virus gene transfer increases anxiety behavior after inescapable stress. J Neurosci 22:4550\u20134562","journal-title":"J Neurosci"},{"key":"4872_CR36","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1017\/S003329179700634X","volume":"28","author":"AJ Cleare","year":"1998","unstructured":"Cleare AJ, Murray RM, Sherwood RA, O'Keane V (1998) Abnormal 5-HT1D receptor function in major depression: a neuropharmacological challenge study using sumatriptan. Psychol Med 28:295\u2013300","journal-title":"Psychol Med"},{"key":"4872_CR37","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0006-8993(95)01297-4","volume":"709","author":"Y Clement","year":"1996","unstructured":"Clement Y, Kia KH, Daval G, Verge D (1996) An autoradiographic study of serotonergic receptors in a murine genetic model of anxiety-related behaviors. Brain Res 709:229\u2013242","journal-title":"Brain Res"},{"issue":"1-2","key":"4872_CR38","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0006-8993(98)00316-3","volume":"795","author":"Val\u00e9rie Compan","year":"1998","unstructured":"Compan V, Segu L, Buhot MC, Daszuta A (1998) Differential effects of serotonin (5-HT) lesions and synthesis blockade on neuropeptide-Y immunoreactivity and 5-HT1A, 5-HT1B\/1D and 5-HT2A\/2C receptor binding sites in the rat cerebral cortex. Brain Res 795:264\u201376","journal-title":"Brain Research"},{"key":"4872_CR39","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/ng0996-98","volume":"14","author":"JC Crabbe","year":"1996","unstructured":"Crabbe JC, Phillips TJ, Feller DJ, Hen R, Wenger CD, Lessov CN, Schafer GL (1996) Elevated alcohol consumption in null mutant mice lacking 5-HT1B serotonin receptors. Nat Genet 14:98\u2013101","journal-title":"Nat Genet"},{"key":"4872_CR40","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1586\/14737175.2014.947965","volume":"14","author":"G Curran","year":"2014","unstructured":"Curran G, Ravindran A (2014) Lithium for bipolar disorder: a review of the recent literature. Expert Rev Neurother 14:1079\u20131098","journal-title":"Expert Rev Neurother"},{"key":"4872_CR41","doi-asserted-by":"crossref","unstructured":"da Cunha-Bang S, Hjordt LV, Perfalk E, Beliveau V, Bock C, Lehel S, Thomsen C, Sestoft D, Svarer C, Knudsen GM (2016) Serotonin 1B receptor binding is associated with trait anger and level of psychopathy in violent offenders. Biol Psychiatry","DOI":"10.1016\/j.biopsych.2016.02.030"},{"key":"4872_CR42","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s002130000588","volume":"153","author":"DJ David","year":"2001","unstructured":"David DJ, Bourin M, Hascoet M, Colombel MC, Baker GB, Jolliet P (2001) Comparison of antidepressant activity in 4- and 40-week-old male mice in the forced swimming test: involvement of 5-HT1A and 5-HT1B receptors in old mice. Psychopharmacology 153:443\u2013449","journal-title":"Psychopharmacology"},{"key":"4872_CR43","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1111\/j.1476-5381.1995.tb13321.x","volume":"114","author":"C Davidson","year":"1995","unstructured":"Davidson C, Stamford JA (1995) Evidence that 5-hydroxytryptamine release in rat dorsal raphe nucleus is controlled by 5-HT1A, 5-HT1B and 5-HT1D autoreceptors. Br J Pharmacol 114:1107\u20131109","journal-title":"Br J Pharmacol"},{"key":"4872_CR44","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.neuropharm.2006.01.010","volume":"50","author":"LA Dawson","year":"2006","unstructured":"Dawson LA, Hughes ZA, Starr KR, Storey JD, Bettelini L, Bacchi F, Arban R, Poffe A, Melotto S, Hagan JJ, Price GW (2006) Characterisation of the selective 5-HT1B receptor antagonist SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2\u2032-met hyl-4\u2032-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): in vivo neurochemical and behavioural evidence of anxiolytic\/antidepressant activity. Neuropharmacology 50:975\u2013983","journal-title":"Neuropharmacology"},{"key":"4872_CR45","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s002130100778","volume":"157","author":"RM Almeida de","year":"2001","unstructured":"de Almeida RM, Nikulina EM, Faccidomo S, Fish EW, Miczek KA (2001) Zolmitriptan\u2014a 5-HT1B\/D agonist, alcohol, and aggression in mice. Psychopharmacology 157:131\u2013141","journal-title":"Psychopharmacology"},{"key":"4872_CR46","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0014-2999(03)02154-X","volume":"476","author":"L Groote De","year":"2003","unstructured":"De Groote L, Olivier B, Westenberg HG (2003) Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice. Eur J Pharmacol 476:71\u201377","journal-title":"Eur J Pharmacol"},{"key":"4872_CR47","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1177\/0269881112472560","volume":"27","author":"MG Rezende de","year":"2013","unstructured":"de Rezende MG, Garcia-Leal C, Graeff FG, Del-Ben CM (2013) The 5-HT1D\/1B receptor agonist sumatriptan enhances fear of simulated speaking and reduces plasma levels of prolactin. J Psychopharmacol 27:1124\u20131133","journal-title":"J Psychopharmacol"},{"key":"4872_CR48","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1073\/pnas.89.12.5522","volume":"89","author":"L Demchyshyn","year":"1992","unstructured":"Demchyshyn L, Sunahara RK, Miller K, Teitler M, Hoffman BJ, Kennedy JL, Seeman P, Van Tol HH, Niznik HB (1992) A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6. Proc Natl Acad Sci U S A 89:5522\u20135526","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4872_CR49","doi-asserted-by":"crossref","first-page":"43411","DOI":"10.1074\/jbc.M408078200","volume":"279","author":"AB Deora","year":"2004","unstructured":"Deora AB, Kreitzer G, Jacovina AT, Hajjar KA (2004) An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface. J Biol Chem 279:43411\u201343418","journal-title":"J Biol Chem"},{"key":"4872_CR50","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1586\/14737175.2014.987131","volume":"14","author":"A Dhir","year":"2014","unstructured":"Dhir A, Sarvaiya J (2014) The efficacy of vortioxetine for the treatment of major depressive disorder. Expert Rev Neurother 14:1349\u20131363","journal-title":"Expert Rev Neurother"},{"key":"4872_CR51","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1176\/appi.ajp.159.10.1783","volume":"159","author":"D Bella Di","year":"2002","unstructured":"Di Bella D, Cavallini MC, Bellodi L (2002) No association between obsessive-compulsive disorder and the 5-HT(1Dbeta) receptor gene. Am J Psychiatry 159:1783\u20131785","journal-title":"Am J Psychiatry"},{"key":"4872_CR52","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1152\/jn.00831.2014","volume":"113","author":"S Ding","year":"2015","unstructured":"Ding S, Li L, Zhou FM (2015) Robust presynaptic serotonin 5-HT(1B) receptor inhibition of the striatonigral output and its sensitization by chronic fluoxetine treatment. J Neurophysiol 113:3397\u20133409","journal-title":"J Neurophysiol"},{"key":"4872_CR53","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0028-3908(91)90050-L","volume":"30","author":"E Edwards","year":"1991","unstructured":"Edwards E, Harkins K, Wright G, Henn FA (1991) 5-HT1b receptors in an animal model of depression. Neuropharmacology 30:101\u2013105","journal-title":"Neuropharmacology"},{"key":"4872_CR54","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.neuropharm.2011.01.046","volume":"61","author":"M Egeland","year":"2011","unstructured":"Egeland M, Warner-Schmidt J, Greengard P, Svenningsson P (2011) Co-expression of serotonin 5-HT(1B) and 5-HT(4) receptors in p11 containing cells in cerebral cortex, hippocampus, caudate-putamen and cerebellum. Neuropharmacology 61:442\u2013450","journal-title":"Neuropharmacology"},{"key":"4872_CR55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00633189","volume":"332","author":"G Engel","year":"1986","unstructured":"Engel G, Gothert M, Hoyer D, Schlicker E, Hillenbrand K (1986) Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Naunyn Schmiedeberg's Arch Pharmacol 332:1\u20137","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"4872_CR56","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1038\/npp.2008.7","volume":"33","author":"S Faccidomo","year":"2008","unstructured":"Faccidomo S, Bannai M, Miczek KA (2008) Escalated aggression after alcohol drinking in male mice: dorsal raphe and prefrontal cortex serotonin and 5-HT(1B) receptors. Neuropsychopharmacology 33:2888\u20132899","journal-title":"Neuropsychopharmacology"},{"key":"4872_CR57","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00213-011-2629-1","volume":"222","author":"S Faccidomo","year":"2012","unstructured":"Faccidomo S, Quadros IM, Takahashi A, Fish EW, Miczek KA (2012) Infralimbic and dorsal raphe microinjection of the 5-HT(1B) receptor agonist CP-93,129: attenuation of aggressive behavior in CFW male mice. Psychopharmacology 222:117\u2013128","journal-title":"Psychopharmacology"},{"key":"4872_CR58","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0166-2236(96)40002-9","volume":"19","author":"L Farde","year":"1996","unstructured":"Farde L (1996) The advantage of using positron emission tomography in drug research. Trends Neurosci 19:211\u2013214","journal-title":"Trends Neurosci"},{"key":"4872_CR59","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/0304-3940(96)12637-9","volume":"209","author":"TJ Feuerstein","year":"1996","unstructured":"Feuerstein TJ, Huring H, van Velthoven V, Lucking CH, Landwehrmeyer GB (1996) 5-HT1D-like receptors inhibit the release of endogenously formed [3H]GABA in human, but not in rabbit, neocortex. Neurosci Lett 209:210\u2013214","journal-title":"Neurosci Lett"},{"key":"4872_CR60","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/PL00005484","volume":"146","author":"EW Fish","year":"1999","unstructured":"Fish EW, Faccidomo S, Miczek KA (1999) Aggression heightened by alcohol or social instigation in mice: reduction by the 5-HT(1B) receptor agonist CP-94,253. Psychopharmacology 146:391\u2013399","journal-title":"Psychopharmacology"},{"key":"4872_CR61","doi-asserted-by":"crossref","first-page":"712","DOI":"10.4088\/JCP.v61n1002","volume":"61","author":"AJ Gelenberg","year":"2000","unstructured":"Gelenberg AJ, Chesen CL (2000) How fast are antidepressants? J Clin Psychiatry 61:712\u2013721","journal-title":"J Clin Psychiatry"},{"key":"4872_CR62","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.1093\/emboj\/cdf469","volume":"21","author":"C Girard","year":"2002","unstructured":"Girard C, Tinel N, Terrenoire C, Romey G, Lazdunski M, Borsotto M (2002) p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK-1. EMBO J 21:4439\u20134448","journal-title":"EMBO J"},{"key":"4872_CR63","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.tins.2006.12.002","volume":"30","author":"F Giuliano","year":"2007","unstructured":"Giuliano F (2007) 5-Hydroxytryptamine in premature ejaculation: opportunities for therapeutic intervention. Trends Neurosci 30:79\u201384","journal-title":"Trends Neurosci"},{"key":"4872_CR64","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000079970","volume":"50","author":"R Gross-Isseroff","year":"2004","unstructured":"Gross-Isseroff R, Cohen R, Sasson Y, Voet H, Zohar J (2004) Serotonergic dissection of obsessive compulsive symptoms: a challenge study with m-chlorophenylpiperazine and sumatriptan. Neuropsychobiology 50:200\u2013205","journal-title":"Neuropsychobiology"},{"key":"4872_CR65","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.neuroscience.2009.11.071","volume":"165","author":"JD Guo","year":"2010","unstructured":"Guo JD, Rainnie DG (2010) Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis. Neuroscience 165:1390\u20131401","journal-title":"Neuroscience"},{"key":"4872_CR66","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0006-8993(02)03193-1","volume":"952","author":"E Gur","year":"2002","unstructured":"Gur E, Dremencov E, Garcia F, Van de Kar LD, Lerer B, Newman ME (2002) Functional effects of chronic electroconvulsive shock on serotonergic 5-HT(1A) and 5-HT(1B) receptor activity in rat hippocampus and hypothalamus. Brain Res 952:52\u201360","journal-title":"Brain Res"},{"key":"4872_CR67","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1097\/00001756-200009110-00019","volume":"11","author":"E Gur","year":"2000","unstructured":"Gur E, Lerer B, Dremencov E, Newman ME (2000) Chronic repetitive transcranial magnetic stimulation induces subsensitivity of presynaptic serotonergic autoreceptor activity in rat brain. Neuroreport 11:2925\u20132929","journal-title":"Neuroreport"},{"key":"4872_CR68","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/syn.21608","volume":"66","author":"CE Hagan","year":"2012","unstructured":"Hagan CE, McDevitt RA, Liu Y, Furay AR, Neumaier JF (2012) 5-HT(1B) autoreceptor regulation of serotonin transporter activity in synaptosomes. Synapse 66:1024\u20131034","journal-title":"Synapse"},{"key":"4872_CR69","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0014-2999(97)01055-8","volume":"331","author":"JJ Hagan","year":"1997","unstructured":"Hagan JJ, Slade PD, Gaster L, Jeffrey P, Hatcher JP, Middlemiss DN (1997) Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig. Eur J Pharmacol 331:169\u2013174","journal-title":"Eur J Pharmacol"},{"key":"4872_CR70","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s10865-012-9452-y","volume":"36","author":"C Hakulinen","year":"2013","unstructured":"Hakulinen C, Jokela M, Hintsanen M, Merjonen P, Pulkki-Raback L, Seppala I, Lyytikainen LP, Lehtimaki T, Kahonen M, Viikari J, Raitakari OT, Keltikangas-Jarvinen L (2013) Serotonin receptor 1B genotype and hostility, anger and aggressive behavior through the lifespan: the Young Finns study. J Behav Med 36:583\u2013590","journal-title":"J Behav Med"},{"key":"4872_CR71","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0006-8993(96)01131-6","volume":"745","author":"H Hall","year":"1997","unstructured":"Hall H, Lundkvist C, Halldin C, Farde L, Pike VW, McCarron JA, Fletcher A, Cliffe IA, Barf T, Wikstrom H, Sedvall G (1997) Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [3H]WAY-100635 and [11C]way-100635. Brain Res 745:96\u2013108","journal-title":"Brain Res"},{"key":"4872_CR72","first-page":"139","volume":"45","author":"C Halldin","year":"2001","unstructured":"Halldin C, Gulyas B, Langer O, Farde L (2001) Brain radioligands\u2014state of the art and new trends. Q J Nucl Med 45:139\u2013152","journal-title":"Q J Nucl Med"},{"key":"4872_CR73","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0022-3565(25)39320-1","volume":"243","author":"MW Hamblin","year":"1987","unstructured":"Hamblin MW, Ariani K, Adriaenssens PI, Ciaranello RD (1987) [3H]dihydroergotamine as a high-affinity, slowly dissociating radioligand for 5-HT1B binding sites in rat brain membranes: evidence for guanine nucleotide regulation of agonist affinity states. J Pharmacol Exp Ther 243:989\u20131001","journal-title":"J Pharmacol Exp Ther"},{"key":"4872_CR74","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/0006-291X(92)90654-4","volume":"184","author":"MW Hamblin","year":"1992","unstructured":"Hamblin MW, Metcalf MA, McGuffin RW, Karpells S (1992) Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity. Biochem Biophys Res Commun 184:752\u2013759","journal-title":"Biochem Biophys Res Commun"},{"key":"4872_CR75","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1152\/jn.01143.2007","volume":"99","author":"K Hashimoto","year":"2008","unstructured":"Hashimoto K, Kita H (2008) Serotonin activates presynaptic and postsynaptic receptors in rat globus pallidus. J Neurophysiol 99:1723\u20131732","journal-title":"J Neurophysiol"},{"key":"4872_CR76","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.neuroscience.2008.10.016","volume":"158","author":"R Hiroi","year":"2009","unstructured":"Hiroi R, Neumaier JF (2009) Estrogen decreases 5-HT1B autoreceptor mRNA in selective subregion of rat dorsal raphe nucleus: inverse association between gene expression and anxiety behavior in the open field. Neuroscience 158:456\u2013464","journal-title":"Neuroscience"},{"key":"4872_CR77","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0014-2999(91)90177-R","volume":"209","author":"S Hjorth","year":"1991","unstructured":"Hjorth S, Tao R (1991) The putative 5-HT1B receptor agonist CP-93,129 suppresses rat hippocampal 5-HT release in vivo: comparison with RU 24969. Eur J Pharmacol 209:249\u2013252","journal-title":"Eur J Pharmacol"},{"key":"4872_CR78","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00213-015-4086-8","volume":"233","author":"EV Ho","year":"2016","unstructured":"Ho EV, Thompson SL, Katzka WR, Sharifi MF, Knowles JA, Dulawa SC (2016) Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation. Psychopharmacology 233:57\u201370","journal-title":"Psychopharmacology"},{"key":"4872_CR79","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.alcohol.2006.04.003","volume":"38","author":"BJ Hoplight","year":"2006","unstructured":"Hoplight BJ, Sandygren NA, Neumaier JF (2006) Increased expression of 5-HT1B receptors in rat nucleus accumbens via virally mediated gene transfer increases voluntary alcohol consumption. Alcohol 38:73\u201379","journal-title":"Alcohol"},{"key":"4872_CR80","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.physbeh.2005.02.016","volume":"84","author":"BJ Hoplight","year":"2005","unstructured":"Hoplight BJ, Vincow ES, Neumaier JF (2005) The effects of SB 224289 on anxiety and cocaine-related behaviors in a novel object task. Physiol Behav 84:707\u2013714","journal-title":"Physiol Behav"},{"key":"4872_CR81","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195313048.001.0001","volume-title":"The loss of sadness\u2014how psychiatry transformed normal sorrow into depressive disorder","author":"A Horwitz","year":"2007","unstructured":"Horwitz A, Wakefield J (2007) The loss of sadness\u2014how psychiatry transformed normal sorrow into depressive disorder. Oxford University Press, Oxford"},{"key":"4872_CR82","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0091-3057(01)00746-8","volume":"71","author":"D Hoyer","year":"2002","unstructured":"Hoyer D, Hannon JP, Martin GR (2002) Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 71:533\u2013554","journal-title":"Pharmacol Biochem Behav"},{"key":"4872_CR83","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.biopsych.2009.12.028","volume":"67","author":"J Hu","year":"2010","unstructured":"Hu J, Henry S, Gallezot JD, Ropchan J, Neumaier JF, Potenza MN, Sinha R, Krystal JH, Huang Y, Ding YS, Carson RE, Neumeister A (2010) Serotonin 1B receptor imaging in alcohol dependence. Biol Psychiatry 67:800\u2013803","journal-title":"Biol Psychiatry"},{"key":"4872_CR84","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.euroneuro.2006.12.002","volume":"17","author":"XJ Hu","year":"2007","unstructured":"Hu XJ, Wang FH, Stenfors C, Ogren SO, Kehr J (2007) Effects of the 5-HT1B receptor antagonist NAS-181 on extracellular levels of acetylcholine, glutamate and GABA in the frontal cortex and ventral hippocampus of awake rats: a microdialysis study. Eur Neuropsychopharmacol 17:580\u2013586","journal-title":"Eur Neuropsychopharmacol"},{"key":"4872_CR85","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0893-133X(99)00030-5","volume":"21","author":"YY Huang","year":"1999","unstructured":"Huang YY, Grailhe R, Arango V, Hen R, Mann JJ (1999) Relationship of psychopathology to the human serotonin1B genotype and receptor binding kinetics in postmortem brain tissue. Neuropsychopharmacology 21:238\u2013246","journal-title":"Neuropsychopharmacology"},{"key":"4872_CR86","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.npp.1300000","volume":"28","author":"YY Huang","year":"2003","unstructured":"Huang YY, Oquendo MA, Friedman JM, Greenhill LL, Brodsky B, Malone KM, Khait V, Mann JJ (2003) Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism. Neuropsychopharmacology 28:163\u2013169","journal-title":"Neuropsychopharmacology"},{"key":"4872_CR87","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1124\/jpet.102.045468","volume":"304","author":"TJ Hudzik","year":"2003","unstructured":"Hudzik TJ, Yanek M, Porrey T, Evenden J, Paronis C, Mastrangelo M, Ryan C, Ross S, Stenfors C (2003) Behavioral pharmacology of AR-A000002, a novel, selective 5-hydroxytryptamine(1B) antagonist. J Pharmacol Exp Ther 304:1072\u20131084","journal-title":"J Pharmacol Exp Ther"},{"key":"4872_CR88","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.1992.72.1.165","volume":"72","author":"BL Jacobs","year":"1992","unstructured":"Jacobs BL, Azmitia EC (1992) Structure and function of the brain serotonin system. Physiol Rev 72:165\u2013229","journal-title":"Physiol Rev"},{"key":"4872_CR89","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0165-1781(02)00136-1","volume":"111","author":"D Januel","year":"2002","unstructured":"Januel D, Massot O, Poirier MF, Olie JP, Fillion G (2002) Interaction of lithium with 5-HT(1B) receptors in depressed unipolar patients treated with clomipramine and lithium versus clomipramine and placebo: preliminary results. Psychiatry Res 111:117\u2013124","journal-title":"Psychiatry Res"},{"key":"4872_CR90","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.1016\/S0021-9258(18)42612-9","volume":"267","author":"H Jin","year":"1992","unstructured":"Jin H, Oksenberg D, Ashkenazi A, Peroutka SJ, Duncan AM, Rozmahel R, Yang Y, Mengod G, Palacios JM, O'Dowd BF (1992) Characterization of the human 5-hydroxytryptamine1B receptor. J Biol Chem 267:5735\u20135738","journal-title":"J Biol Chem"},{"key":"4872_CR91","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1523\/JNEUROSCI.12-05-02000.1992","volume":"12","author":"SW Johnson","year":"1992","unstructured":"Johnson SW, Mercuri NB, North RA (1992) 5-Hydroxytryptamine1B receptors block the GABAB synaptic potential in rat dopamine neurons. J Neurosci 12:2000\u20132006","journal-title":"J Neurosci"},{"key":"4872_CR92","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/sj.npp.1300664","volume":"30","author":"MD Jones","year":"2005","unstructured":"Jones MD, Lucki I (2005) Sex differences in the regulation of serotonergic transmission and behavior in 5-HT receptor knockout mice. Neuropsychopharmacology 30:1039\u20131047","journal-title":"Neuropsychopharmacology"},{"key":"4872_CR93","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0091-3057(03)00152-7","volume":"75","author":"KJ Kaiyala","year":"2003","unstructured":"Kaiyala KJ, Vincow ES, Sexton TJ, Neumaier JF (2003) 5-HT1B receptor mRNA levels in dorsal raphe nucleus: inverse association with anxiety behavior in the elevated plus maze. Pharmacol Biochem Behav 75:769\u2013776","journal-title":"Pharmacol Biochem Behav"},{"key":"4872_CR94","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000209861","volume":"59","author":"SJ Kim","year":"2009","unstructured":"Kim SJ, Namkoong K, Kang JI, Kim CH (2009) Association of a 5-HT1Dbeta receptor gene polymorphism with obsessive-compulsive disorder in Korean male subjects. Neuropsychobiology 59:96\u201399","journal-title":"Neuropsychobiology"},{"key":"4872_CR95","doi-asserted-by":"crossref","unstructured":"Klein AK, Brito MA, Akhavan S, Flanagan DR, Le N, Ohana T, Patil AS, Purvis EM, Provenzano C, Wei A, Zhou L, Ettenberg A (2016) Attenuation of the anxiogenic effects of cocaine by 5-HT1B autoreceptor stimulation in the bed nucleus of the stria terminalis of rats. Psychopharmacology (Berl)","DOI":"10.1007\/s00213-016-4479-3"},{"key":"4872_CR96","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0022-3565(24)29477-5","volume":"298","author":"DA Knobelman","year":"2001","unstructured":"Knobelman DA, Hen R, Lucki I (2001) Genetic regulation of extracellular serotonin by 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) autoreceptors in different brain regions of the mouse. J Pharmacol Exp Ther 298:1083\u20131091","journal-title":"J Pharmacol Exp Ther"},{"key":"4872_CR97","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1046\/j.1471-4159.1995.65062671.x","volume":"65","author":"X Langlois","year":"1995","unstructured":"Langlois X, Gerard C, Darmon M, Chauveau J, Hamon M, el Mestikawy S (1995) Immunolabeling of central serotonin 5-HT1D beta receptors in the rat, mouse, and guinea pig with a specific anti-peptide antiserum. J Neurochem 65:2671\u20132681","journal-title":"J Neurochem"},{"key":"4872_CR98","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0140-6736(69)91140-4","volume":"1","author":"IP Lapin","year":"1969","unstructured":"Lapin IP, Oxenkrug GF (1969) Intensification of the central serotoninergic processes as a possible determinant of the thymoleptic effect. Lancet 1:132\u2013136","journal-title":"Lancet"},{"key":"4872_CR99","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1001\/archpsyc.55.11.989","volume":"55","author":"J Lappalainen","year":"1998","unstructured":"Lappalainen J, Long JC, Eggert M, Ozaki N, Robin RW, Brown GL, Naukkarinen H, Virkkunen M, Linnoila M, Goldman D (1998) Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. Arch Gen Psychiatry 55:989\u2013994","journal-title":"Arch Gen Psychiatry"},{"key":"4872_CR100","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1038\/mp.2015.132","volume":"20","author":"KW Lee","year":"2015","unstructured":"Lee KW, Westin L, Kim J, Chang JC, Oh YS, Amreen B, Gresack J, Flajolet M, Kim D, Aperia A, Kim Y, Greengard P (2015) Alteration by p11 of mGluR5 localization regulates depression-like behaviors. Mol Psychiatry 20:1546\u20131556","journal-title":"Mol Psychiatry"},{"key":"4872_CR101","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.pharmthera.2004.10.012","volume":"105","author":"AG Leenders","year":"2005","unstructured":"Leenders AG, Sheng ZH (2005) Modulation of neurotransmitter release by the second messenger-activated protein kinases: implications for presynaptic plasticity. Pharmacol Ther 105:69\u201384","journal-title":"Pharmacol Ther"},{"key":"4872_CR102","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0014-5793(92)80379-U","volume":"296","author":"FO Levy","year":"1992","unstructured":"Levy FO, Gudermann T, Birnbaumer M, Kaumann AJ, Birnbaumer L (1992a) Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. FEBS Lett 296:201\u2013206","journal-title":"FEBS Lett"},{"key":"4872_CR103","doi-asserted-by":"crossref","first-page":"7553","DOI":"10.1016\/S0021-9258(18)42552-5","volume":"267","author":"FO Levy","year":"1992","unstructured":"Levy FO, Gudermann T, Perez-Reyes E, Birnbaumer M, Kaumann AJ, Birnbaumer L (1992b) Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype. J Biol Chem 267:7553\u20137562","journal-title":"J Biol Chem"},{"key":"4872_CR104","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1017\/S1461145711001453","volume":"15","author":"T Lifschytz","year":"2012","unstructured":"Lifschytz T, Broner EC, Zozulinsky P, Slonimsky A, Eitan R, Greenbaum L, Lerer B (2012) Relationship between Rgs2 gene expression level and anxiety and depression-like behaviour in a mutant mouse model: serotonergic involvement. Int J Neuropsychopharmacol 15:1307\u20131318","journal-title":"Int J Neuropsychopharmacol"},{"key":"4872_CR105","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jneumeth.2004.03.028","volume":"140","author":"T Lifschytz","year":"2004","unstructured":"Lifschytz T, Gur E, Lerer B, Newman ME (2004) Effects of triiodothyronine and fluoxetine on 5-HT1A and 5-HT1B autoreceptor activity in rat brain: regional differences. J Neurosci Methods 140:133\u2013139","journal-title":"J Neurosci Methods"},{"key":"4872_CR106","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF00179039","volume":"343","author":"N Limberger","year":"1991","unstructured":"Limberger N, Deicher R, Starke K (1991) Species differences in presynaptic serotonin autoreceptors: mainly 5-HT1B but possibly in addition 5-HT1D in the rat, 5-HT1D in the rabbit and guinea-pig brain cortex. Naunyn Schmiedeberg's Arch Pharmacol 343:353\u2013364","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"4872_CR107","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0091-3057(01)00712-2","volume":"71","author":"D Lin","year":"2002","unstructured":"Lin D, Parsons LH (2002) Anxiogenic-like effect of serotonin (1B) receptor stimulation in the rat elevated plus-maze. Pharmacol Biochem Behav 71:581\u2013587","journal-title":"Pharmacol Biochem Behav"},{"key":"4872_CR108","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.biopsych.2003.09.017","volume":"55","author":"AL Lopez-Figueroa","year":"2004","unstructured":"Lopez-Figueroa AL, Norton CS, Lopez-Figueroa MO, Armellini-Dodel D, Burke S, Akil H, Lopez JF, Watson SJ (2004) Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia. Biol Psychiatry 55:225\u2013233","journal-title":"Biol Psychiatry"},{"key":"4872_CR109","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1046\/j.1471-4159.2001.00083.x","volume":"76","author":"I Malagie","year":"2001","unstructured":"Malagie I, Trillat AC, Bourin M, Jacquot C, Hen R, Gardier AM (2001) 5-HT1B autoreceptors limit the effects of selective serotonin re-uptake inhibitors in mouse hippocampus and frontal cortex. J Neurochem 76:865\u2013871","journal-title":"J Neurochem"},{"key":"4872_CR110","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1073\/pnas.89.7.3020","volume":"89","author":"L Maroteaux","year":"1992","unstructured":"Maroteaux L, Saudou F, Amlaiky N, Boschert U, Plassat JL, Hen R (1992) Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A 89:3020\u20133024","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4872_CR111","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1476-5381.1992.tb14306.x","volume":"106","author":"KF Martin","year":"1992","unstructured":"Martin KF, Hannon S, Phillips I, Heal DJ (1992) Opposing roles for 5-HT1B and 5-HT3 receptors in the control of 5-HT release in rat hippocampus in vivo. Br J Pharmacol 106:139\u2013142","journal-title":"Br J Pharmacol"},{"key":"4872_CR112","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/gbb.12128","volume":"13","author":"S Mas","year":"2014","unstructured":"Mas S, Pagerols M, Gasso P, Ortiz A, Rodriguez N, Morer A, Plana MT, Lafuente A, Lazaro L (2014) Role of GAD2 and HTR1B genes in early-onset obsessive-compulsive disorder: results from transmission disequilibrium study. Genes Brain Behav 13:409\u2013417","journal-title":"Genes Brain Behav"},{"key":"4872_CR113","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S0893-133X(99)00042-1","volume":"21","author":"O Massot","year":"1999","unstructured":"Massot O, Rousselle JC, Fillion MP, Januel D, Plantefol M, Fillion G (1999) 5-HT1B receptors: a novel target for lithium. Possible involvement in mood disorders. Neuropsychopharmacology 21:530\u2013541","journal-title":"Neuropsychopharmacology"},{"key":"4872_CR114","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.biopsych.2013.11.022","volume":"76","author":"D Matuskey","year":"2014","unstructured":"Matuskey D, Bhagwagar Z, Planeta B, Pittman B, Gallezot JD, Chen J, Wanyiri J, Najafzadeh S, Ropchan J, Geha P, Huang Y, Potenza MN, Neumeister A, Carson RE, Malison RT (2014) Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans. Biol Psychiatry 76:816\u2013822","journal-title":"Biol Psychiatry"},{"key":"4872_CR115","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1021\/jm9811054","volume":"43","author":"L Matzen","year":"2000","unstructured":"Matzen L, van Amsterdam C, Rautenberg W, Greiner HE, Harting J, Seyfried CA, Bottcher H (2000) 5-HT reuptake inhibitors with 5-HT(1B\/1D) antagonistic activity: a new approach toward efficient antidepressants. J Med Chem 43:1149\u20131157","journal-title":"J Med Chem"},{"key":"4872_CR116","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0014-2999(86)90443-7","volume":"129","author":"G Maura","year":"1986","unstructured":"Maura G, Raiteri M (1986) Cholinergic terminals in rat hippocampus possess 5-HT1B receptors mediating inhibition of acetylcholine release. Eur J Pharmacol 129:333\u2013337","journal-title":"Eur J Pharmacol"},{"key":"4872_CR117","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0014-2999(99)00125-9","volume":"370","author":"S Maurel","year":"1999","unstructured":"Maurel S, De Vry J, Schreiber R (1999) 5-HT receptor ligands differentially affect operant oral self-administration of ethanol in the rat. Eur J Pharmacol 370:217\u2013223","journal-title":"Eur J Pharmacol"},{"key":"4872_CR118","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1176\/jnp.9.3.471","volume":"9","author":"HS Mayberg","year":"1997","unstructured":"Mayberg HS (1997) Limbic-cortical dysregulation: a proposed model of depression. J Neuropsychiatry Clin Neurosci 9:471\u2013481","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"4872_CR119","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0022-3565(24)29479-9","volume":"298","author":"AJ Mayorga","year":"2001","unstructured":"Mayorga AJ, Dalvi A, Page ME, Zimov-Levinson S, Hen R, Lucki I (2001) Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice. J Pharmacol Exp Ther 298:1101\u20131107","journal-title":"J Pharmacol Exp Ther"},{"key":"4872_CR120","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0741-8329(96)00117-6","volume":"14","author":"WJ McBride","year":"1997","unstructured":"McBride WJ, Chernet E, Russell RN, Wong DT, Guan XM, Lumeng L, Li TK (1997) Regional CNS densities of monoamine receptors in alcohol-naive alcohol-preferring P and -nonpreferring NP rats. Alcohol 14:141\u2013148","journal-title":"Alcohol"},{"key":"4872_CR121","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/0006-2952(92)90092-W","volume":"44","author":"MA Metcalf","year":"1992","unstructured":"Metcalf MA, McGuffin RW, Hamblin MW (1992) Conversion of the human 5-HT1D beta serotonin receptor to the rat 5-HT1B ligand-binding phenotype by Thr355Asn site directed mutagenesis. Biochem Pharmacol 44:1917\u20131920","journal-title":"Biochem Pharmacol"},{"key":"4872_CR122","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0014-2999(84)90173-0","volume":"101","author":"DN Middlemiss","year":"1984","unstructured":"Middlemiss DN (1984) Stereoselective blockade at [3H]5-HT binding sites and at the 5-HT autoreceptor by propranolol. Eur J Pharmacol 101:289\u2013293","journal-title":"Eur J Pharmacol"},{"key":"4872_CR123","unstructured":"Middlemiss DN, Hutson PH (1990) The 5-HT1B receptors. Ann N Y Acad Sci 600:132\u2013147 discussion 347-48"},{"key":"4872_CR124","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/S1734-1140(11)70695-8","volume":"63","author":"J Miszkiel","year":"2011","unstructured":"Miszkiel J, Filip M, Przegalinski E (2011) Role of serotonin 5-HT1B receptors in psychostimulant addiction. Pharmacol Rep 63:1310\u20131315","journal-title":"Pharmacol Rep"},{"key":"4872_CR125","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neuint.2013.11.004","volume":"73","author":"S Montanez","year":"2014","unstructured":"Montanez S, Munn JL, Owens WA, Horton RE, Daws LC (2014) 5-HT1B receptor modulation of the serotonin transporter in vivo: studies using KO mice. Neurochem Int 73:127\u2013131","journal-title":"Neurochem Int"},{"key":"4872_CR126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(00)00581-1","volume":"404","author":"C Moret","year":"2000","unstructured":"Moret C, Briley M (2000) The possible role of 5-HT(1B\/D) receptors in psychiatric disorders and their potential as a target for therapy. Eur J Pharmacol 404:1\u201312","journal-title":"Eur J Pharmacol"},{"key":"4872_CR127","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1176\/appi.ajp.157.7.1160","volume":"157","author":"E Mundo","year":"2000","unstructured":"Mundo E, Richter MA, Sam F, Macciardi F, Kennedy JL (2000) Is the 5-HT(1Dbeta) receptor gene implicated in the pathogenesis of obsessive-compulsive disorder? Am J Psychiatry 157:1160\u20131161","journal-title":"Am J Psychiatry"},{"key":"4872_CR128","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1001\/archgenpsychiatry.2011.91","volume":"68","author":"JW Murrough","year":"2011","unstructured":"Murrough JW, Czermak C, Henry S, Nabulsi N, Gallezot JD, Gueorguieva R, Planeta-Wilson B, Krystal JH, Neumaier JF, Huang Y, Ding YS, Carson RE, Neumeister A (2011a) The effect of early trauma exposure on serotonin type 1B receptor expression revealed by reduced selective radioligand binding. Arch Gen Psychiatry 68:892\u2013900","journal-title":"Arch Gen Psychiatry"},{"key":"4872_CR129","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00213-010-1881-0","volume":"213","author":"JW Murrough","year":"2011","unstructured":"Murrough JW, Henry S, Hu J, Gallezot JD, Planeta-Wilson B, Neumaier JF, Neumeister A (2011b) Reduced ventral striatal\/ventral pallidal serotonin1B receptor binding potential in major depressive disorder. Psychopharmacology 213:547\u2013553","journal-title":"Psychopharmacology"},{"key":"4872_CR130","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.biopsych.2011.02.020","volume":"69","author":"JW Murrough","year":"2011","unstructured":"Murrough JW, Neumeister A (2011) The serotonin 1B receptor: a new target for depression therapeutics? Biol Psychiatry 69:714\u2013715","journal-title":"Biol Psychiatry"},{"key":"4872_CR131","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.pbb.2013.09.009","volume":"112","author":"SG Nair","year":"2013","unstructured":"Nair SG, Furay AR, Liu Y, Neumaier JF (2013) Differential effect of viral overexpression of nucleus accumbens shell 5-HT1B receptors on stress- and cocaine priming-induced reinstatement of cocaine seeking. Pharmacol Biochem Behav 112:89\u201395","journal-title":"Pharmacol Biochem Behav"},{"key":"4872_CR132","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.neuron.2015.03.041","volume":"86","author":"KM Nautiyal","year":"2015","unstructured":"Nautiyal KM, Tanaka KF, Barr MM, Tritschler L, Le Dantec Y, David DJ, Gardier AM, Blanco C, Hen R, Ahmari SE (2015) Distinct circuits underlie the effects of 5-HT1B receptors on aggression and impulsivity. Neuron 86:813\u2013826","journal-title":"Neuron"},{"key":"4872_CR133","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1038\/npp.2016.109","volume":"41","author":"KM Nautiyal","year":"2016","unstructured":"Nautiyal KM, Tritschler L, Ahmari SE, David DJ, Gardier AM, Hen R (2016) A lack of serotonin 1B autoreceptors results in decreased anxiety and depression-related behaviors. Neuropsychopharmacology 41:2941\u20132950","journal-title":"Neuropsychopharmacology"},{"issue":"Pt B","key":"4872_CR134","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuropharm.2013.08.014","volume":"76","author":"JL Neisewander","year":"2014","unstructured":"Neisewander JL, Cheung TH, Pentkowski NS (2014) Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development. Neuropharmacology 76(Pt B):301\u2013319","journal-title":"Neuropharmacology"},{"key":"4872_CR135","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jad.2014.05.053","volume":"168","author":"JC Nelson","year":"2014","unstructured":"Nelson JC, Baumann P, Delucchi K, Joffe R, Katona C (2014) A systematic review and meta-analysis of lithium augmentation of tricyclic and second generation antidepressants in major depression. J Affect Disord 168:269\u2013275","journal-title":"J Affect Disord"},{"key":"4872_CR136","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0006-3223(01)01371-3","volume":"51","author":"JF Neumaier","year":"2002","unstructured":"Neumaier JF, Edwards E, Plotsky PM (2002) 5-HT(1B) mrna regulation in two animal models of altered stress reactivity. Biol Psychiatry 51:902\u2013908","journal-title":"Biol Psychiatry"},{"key":"4872_CR137","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1471-4159.2009.06313.x","volume":"111","author":"JF Neumaier","year":"2009","unstructured":"Neumaier JF, McDevitt RA, Polis IY, Parsons LH (2009) Acquisition of and withdrawal from cocaine self-administration regulates 5-HT mRNA expression in rat striatum. J Neurochem 111:217\u2013227","journal-title":"J Neurochem"},{"key":"4872_CR138","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S0006-3223(96)00114-X","volume":"41","author":"JF Neumaier","year":"1997","unstructured":"Neumaier JF, Petty F, Kramer GL, Szot P, Hamblin MW (1997) Learned helplessness increases 5-hydroxytryptamine1B receptor mRNA levels in the rat dorsal raphe nucleus. Biol Psychiatry 41:668\u2013674","journal-title":"Biol Psychiatry"},{"key":"4872_CR139","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0893-133X(96)00095-4","volume":"15","author":"JF Neumaier","year":"1996","unstructured":"Neumaier JF, Root DC, Hamblin MW (1996) Chronic fluoxetine reduces serotonin transporter mRNA and 5-HT1B mRNA in a sequential manner in the rat dorsal raphe nucleus. Neuropsychopharmacology 15:515\u2013522","journal-title":"Neuropsychopharmacology"},{"key":"4872_CR140","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuint.2008.12.011","volume":"54","author":"K Nishi","year":"2009","unstructured":"Nishi K, Kanemaru K, Diksic M (2009) A genetic rat model of depression, flinders sensitive line, has a lower density of 5-HT(1A) receptors, but a higher density of 5-HT(1B) receptors, compared to control rats. Neurochem Int 54:299\u2013307","journal-title":"Neurochem Int"},{"key":"4872_CR141","doi-asserted-by":"crossref","unstructured":"Nord M, Finnema SJ, Halldin C, Farde L (2013) Effect of a single dose of escitalopram on serotonin concentration in the non-human and human primate brain. Int J Neuropsychopharmacol:1\u201310","DOI":"10.1017\/S1461145712001617"},{"key":"4872_CR142","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.pbb.2014.09.022","volume":"126","author":"M Nowicki","year":"2014","unstructured":"Nowicki M, Tran S, Muraleetharan A, Markovic S, Gerlai R (2014) Serotonin antagonists induce anxiolytic and anxiogenic-like behavior in zebrafish in a receptor-subtype dependent manner. Pharmacol Biochem Behav 126:170\u2013180","journal-title":"Pharmacol Biochem Behav"},{"issue":"Suppl 1","key":"4872_CR143","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00004850-200206001-00002","volume":"17","author":"DJ Nutt","year":"2002","unstructured":"Nutt DJ (2002) The neuropharmacology of serotonin and noradrenaline in depression. Int Clin Psychopharmacol 17(Suppl 1):S1\u201312","journal-title":"Int Clin Psychopharmacol"},{"key":"4872_CR144","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0006-8993(94)91889-9","volume":"640","author":"JJ O'Connor","year":"1994","unstructured":"O'Connor JJ, Kruk ZL (1994) Effects of 21 days treatment with fluoxetine on stimulated endogenous 5-hydroxytryptamine overflow in the rat dorsal raphe and suprachiasmatic nucleus studied using fast cyclic voltammetry in vitro. Brain Res 640:328\u2013335","journal-title":"Brain Res"},{"key":"4872_CR145","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1124\/jpet.104.069278","volume":"311","author":"LE O'Dell","year":"2004","unstructured":"O'Dell LE, Parsons LH (2004) Serotonin1B receptors in the ventral tegmental area modulate cocaine-induced increases in nucleus accumbens dopamine levels. J Pharmacol Exp Ther 311:711\u2013719","journal-title":"J Pharmacol Exp Ther"},{"key":"4872_CR146","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/0091-3057(95)02047-0","volume":"53","author":"MF O'Neill","year":"1996","unstructured":"O'Neill MF, Fernandez AG, Palacios JM (1996) GR 127935 blocks the locomotor and antidepressant-like effects of RU 24969 and the action of antidepressants in the mouse tail suspension test. Pharmacol Biochem Behav 53:535\u2013539","journal-title":"Pharmacol Biochem Behav"},{"key":"4872_CR147","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/360161a0","volume":"360","author":"D Oksenberg","year":"1992","unstructured":"Oksenberg D, Marsters SA, O'Dowd BF, Jin H, Havlik S, Peroutka SJ, Ashkenazi A (1992) A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors. Nature 360:161\u2013163","journal-title":"Nature"},{"key":"4872_CR148","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nature00781","volume":"417","author":"K Okuse","year":"2002","unstructured":"Okuse K, Malik-Hall M, Baker MD, Poon WY, Kong H, Chao MV, Wood JN (2002) Annexin II light chain regulates sensory neuron-specific sodium channel expression. Nature 417:653\u2013656","journal-title":"Nature"},{"issue":"Suppl 2","key":"4872_CR149","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1055\/s-2007-979624","volume":"28","author":"B Olivier","year":"1995","unstructured":"Olivier B, Mos J, van Oorschot R, Hen R (1995) Serotonin receptors and animal models of aggressive behavior. Pharmacopsychiatry 28(Suppl 2):80\u201390","journal-title":"Pharmacopsychiatry"},{"issue":"6","key":"4872_CR150","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1600-0447.2011.01744.x","volume":"124","author":"SD Ostergaard","year":"2011","unstructured":"Ostergaard SD, Jensen SO, Bech P (2011) The heterogeneity of the depressive syndrome: when numbers get serious. Acta Psychiatr Scand 124(6):495\u2013496","journal-title":"Acta Psychiatr Scand"},{"key":"4872_CR151","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1471-4159.1993.tb05865.x","volume":"60","author":"EM Parker","year":"1993","unstructured":"Parker EM, Grisel DA, Iben LG, Shapiro RA (1993) A single amino acid difference accounts for the pharmacological distinctions between the rat and human 5-hydroxytryptamine1B receptors. J Neurochem 60:380\u2013383","journal-title":"J Neurochem"},{"key":"4872_CR152","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/med.20245","volume":"33","author":"LM Paterson","year":"2013","unstructured":"Paterson LM, Kornum BR, Nutt DJ, Pike VW, Knudsen GM (2013) 5-HT radioligands for human brain imaging with PET and SPECT. Med Res Rev 33:54\u2013111","journal-title":"Med Res Rev"},{"key":"4872_CR153","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.neulet.2010.09.024","volume":"485","author":"CJ Peddie","year":"2010","unstructured":"Peddie CJ, Davies HA, Colyer FM, Stewart MG, Rodriguez JJ (2010) A subpopulation of serotonin 1B receptors colocalize with the AMPA receptor subunit GluR2 in the hippocampal dentate gyrus. Neurosci Lett 485:251\u2013255","journal-title":"Neurosci Lett"},{"key":"4872_CR154","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.biopsych.2012.03.024","volume":"72","author":"NS Pentkowski","year":"2012","unstructured":"Pentkowski NS, Cheung TH, Toy WA, Adams MD, Neumaier JF, Neisewander JL (2012) Protracted withdrawal from cocaine self-administration flips the switch on 5-HT(1B) receptor modulation of cocaine abuse-related behaviors. Biol Psychiatry 72:396\u2013404","journal-title":"Biol Psychiatry"},{"key":"4872_CR155","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.brainres.2003.10.059","volume":"998","author":"D Peruzzi","year":"2004","unstructured":"Peruzzi D, Dut A (2004) GABA, serotonin and serotonin receptors in the rat inferior colliculus. Brain Res 998:247\u2013250","journal-title":"Brain Res"},{"key":"4872_CR156","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jad.2016.02.021","volume":"196","author":"C Pittenger","year":"2016","unstructured":"Pittenger C, Adams TG Jr, Gallezot JD, Crowley MJ, Nabulsi N, James R, Gao H, Kichuk SA, Simpson R, Billingslea E, Hannestad J, Bloch M, Mayes L, Bhagwagar Z, Carson RE (2016) OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding. J Affect Disord 196:87\u201396","journal-title":"J Affect Disord"},{"key":"4872_CR157","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/15622975.2011.598559","volume":"14","author":"MN Potenza","year":"2013","unstructured":"Potenza MN, Walderhaug E, Henry S, Gallezot JD, Planeta-Wilson B, Ropchan J, Neumeister A (2013) Serotonin 1B receptor imaging in pathological gambling. World J Biol Psychiatry 14:139\u2013145","journal-title":"World J Biol Psychiatry"},{"key":"4872_CR158","first-page":"312","volume":"10","author":"LH Price","year":"1990","unstructured":"Price LH, Charney DS, Delgado PL, Heninger GR (1990) Fenfluramine augmentation in tricyclic-refractory. depression J Clin Psychopharmacol 10:312\u2013317","journal-title":"depression J Clin Psychopharmacol"},{"key":"4872_CR159","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2174\/157488611798918737","volume":"6","author":"M Raja","year":"2011","unstructured":"Raja M (2011) Lithium and kidney, 60 years later. Curr Drug Saf 6:291\u2013303","journal-title":"Curr Drug Saf"},{"key":"4872_CR160","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0166-4328(96)00119-2","volume":"73","author":"S Ramboz","year":"1996","unstructured":"Ramboz S, Saudou F, Amara DA, Belzung C, Segu L, Misslin R, Buhot MC, Hen R (1996) 5-HT1B receptor knock out--behavioral consequences. Behav Brain Res 73:305\u2013312","journal-title":"Behav Brain Res"},{"key":"4872_CR161","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s002130050846","volume":"141","author":"JP Redrobe","year":"1999","unstructured":"Redrobe JP, Bourin M (1999) Evidence of the activity of lithium on 5-HT1B receptors in the mouse forced swimming test: comparison with carbamazepine and sodium valproate. Psychopharmacology 141:370\u2013377","journal-title":"Psychopharmacology"},{"key":"4872_CR162","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0014-2999(96)00772-8","volume":"318","author":"JP Redrobe","year":"1996","unstructured":"Redrobe JP, Mac Sweeney CP, Bourin M (1996) The role of 5-HT1A and 5-HT1B receptors in antidepressant drug actions in the mouse forced swimming test. Eur J Pharmacol 318:213\u2013220","journal-title":"Eur J Pharmacol"},{"key":"4872_CR163","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.pbb.2007.07.016","volume":"88","author":"A Rex","year":"2008","unstructured":"Rex A, Voigt JP, Wicke KM, Fink H (2008) In vivo\/ex vivo and behavioural study on central effects of 5-HT1B\/1D and 5-HT1A antagonists in guinea pigs. Pharmacol Biochem Behav 88:196\u2013204","journal-title":"Pharmacol Biochem Behav"},{"key":"4872_CR164","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0278-5846(01)00167-1","volume":"25","author":"O Rilke","year":"2001","unstructured":"Rilke O, Will K, Jahkel M, Oehler J (2001) Behavioral and neurochemical effects of anpirtoline and citalopram in isolated and group housed mice. Prog Neuro-Psychopharmacol Biol Psychiatry 25:1125\u20131144","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"4872_CR165","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1527-3458.2001.tb00209.x","volume":"7","author":"C Roberts","year":"2001","unstructured":"Roberts C, Watson J, Price GW, Middlemiss DN (2001) SB-236057-A: a selective 5-HT1B receptor inverse agonist. CNS Drug Rev 7:433\u2013444","journal-title":"CNS Drug Rev"},{"key":"4872_CR166","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/30259","volume":"393","author":"BA Rocha","year":"1998","unstructured":"Rocha BA, Scearce-Levie K, Lucas JJ, Hiroi N, Castanon N, Crabbe JC, Nestler EJ, Hen R (1998) Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. Nature 393:175\u2013178","journal-title":"Nature"},{"key":"4872_CR167","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1038\/sj.bjp.0704827","volume":"136","author":"G Rodriguez-Manzo","year":"2002","unstructured":"Rodriguez-Manzo G, Lopez-Rubalcava C, Hen R, Fernandez-Guasti A (2002) Participation of 5-HT(1B) receptors in the inhibitory actions of serotonin on masculine sexual behaviour of mice: pharmacological analysis in 5-HT(1B) receptor knockout mice. Br J Pharmacol 136:1127\u20131134","journal-title":"Br J Pharmacol"},{"key":"4872_CR168","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0091-3057(01)00669-4","volume":"71","author":"RB Rothman","year":"2002","unstructured":"Rothman RB, Baumann MH (2002) Serotonin releasing agents. Neurochemical, therapeutic and adverse effects. Pharmacol Biochem Behav 71:825\u2013836","journal-title":"Pharmacol Biochem Behav"},{"key":"4872_CR169","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.2174\/138945009789735192","volume":"10","author":"BM Ruf","year":"2009","unstructured":"Ruf BM, Bhagwagar Z (2009) The 5-HT1B receptor: a novel target for the pathophysiology of depression. Curr Drug Targets 10:1118\u20131138","journal-title":"Curr Drug Targets"},{"key":"4872_CR170","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.brainresbull.2006.04.004","volume":"70","author":"S Rutz","year":"2006","unstructured":"Rutz S, Riegert C, Rothmaier AK, Buhot MC, Cassel JC, Jackisch R (2006) Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice. Brain Res Bull 70:81\u201393","journal-title":"Brain Res Bull"},{"key":"4872_CR171","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.pharmthera.2014.07.001","volume":"145","author":"C Sanchez","year":"2015","unstructured":"Sanchez C, Asin KE, Artigas F (2015) Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data. Pharmacol Ther 145:43\u201357","journal-title":"Pharmacol Ther"},{"key":"4872_CR172","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.neubiorev.2004.08.008","volume":"28","author":"Y Sari","year":"2004","unstructured":"Sari Y (2004) Serotonin1B receptors: from protein to physiological function and behavior. Neurosci Biobehav Rev 28:565\u2013582","journal-title":"Neurosci Biobehav Rev"},{"key":"4872_CR173","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0306-4522(98)00256-5","volume":"88","author":"Y Sari","year":"1999","unstructured":"Sari Y, Miquel MC, Brisorgueil MJ, Ruiz G, Doucet E, Hamon M, Verge D (1999) Cellular and subcellular localization of 5-hydroxytryptamine1B receptors in the rat central nervous system: immunocytochemical, autoradiographic and lesion studies. Neuroscience 88:899\u2013915","journal-title":"Neuroscience"},{"key":"4872_CR174","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1126\/science.8091214","volume":"265","author":"F Saudou","year":"1994","unstructured":"Saudou F, Amara DA, Dierich A, LeMeur M, Ramboz S, Segu L, Buhot MC, Hen R (1994) Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science 265:1875\u20131878","journal-title":"Science"},{"key":"4872_CR175","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0197-0186(94)90150-3","volume":"25","author":"F Saudou","year":"1994","unstructured":"Saudou F, Hen R (1994) 5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates. Neurochem Int 25:503\u2013532","journal-title":"Neurochem Int"},{"key":"4872_CR176","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pneurobio.2009.01.009","volume":"88","author":"J Savitz","year":"2009","unstructured":"Savitz J, Lucki I, Drevets WC (2009) 5-HT(1A) receptor function in major depressive disorder. Prog Neurobiol 88:17\u201331","journal-title":"Prog Neurobiol"},{"key":"4872_CR177","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0193-953X(05)70181-7","volume":"23","author":"S Saxena","year":"2000","unstructured":"Saxena S, Rauch SL (2000) Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr Clin North Am 23:563\u2013586","journal-title":"Psychiatr Clin North Am"},{"key":"4872_CR178","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/PL00005057","volume":"356","author":"E Schlicker","year":"1997","unstructured":"Schlicker E, Fink K, Molderings GJ, Price GW, Duckworth M, Gaster L, Middlemiss DN, Zentner J, Likungu J, Gothert M (1997) Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors. Naunyn Schmiedeberg's Arch Pharmacol 356:321\u2013327","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"4872_CR179","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1476-5381.1989.tb11815.x","volume":"96","author":"T Sharp","year":"1989","unstructured":"Sharp T, Bramwell SR, Grahame-Smith DG (1989) 5-HT1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. Br J Pharmacol 96:283\u2013290","journal-title":"Br J Pharmacol"},{"key":"4872_CR180","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.neuroscience.2007.12.001","volume":"151","author":"KZ Shen","year":"2008","unstructured":"Shen KZ, Johnson SW (2008) 5-HT inhibits synaptic transmission in rat subthalamic nucleus neurons in vitro. Neuroscience 151:1029\u20131033","journal-title":"Neuroscience"},{"key":"4872_CR181","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.neulet.2013.11.034","volume":"559","author":"SS Shrestha","year":"2014","unstructured":"Shrestha SS, Pine DS, Luckenbaugh DA, Varnas K, Henter ID, Innis RB, Mathe AA, Svenningsson P (2014) Antidepressant effects on serotonin 1A\/1B receptors in the rat brain using a gene x environment model. Neurosci Lett 559:163\u2013168","journal-title":"Neurosci Lett"},{"key":"4872_CR182","doi-asserted-by":"crossref","first-page":"559","DOI":"10.2174\/1568026023393903","volume":"2","author":"A Slassi","year":"2002","unstructured":"Slassi A (2002) Recent advances in 5-HT1B\/1D receptor antagonists and agonists and their potential therapeutic applications. Curr Top Med Chem 2:559\u2013574","journal-title":"Curr Top Med Chem"},{"key":"4872_CR183","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.neulet.2011.09.058","volume":"504","author":"J Solati","year":"2011","unstructured":"Solati J, Salari AA, Bakhtiari A (2011) 5HT(1A) and 5HT(1B) receptors of medial prefrontal cortex modulate anxiogenic-like behaviors in rats. Neurosci Lett 504:325\u2013329","journal-title":"Neurosci Lett"},{"key":"4872_CR184","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1460-9568.1990.tb00026.x","volume":"2","author":"C Sotelo","year":"1990","unstructured":"Sotelo C, Cholley B, El Mestikawy S, Gozlan H, Hamon M (1990) Direct Immunohistochemical evidence of the existence of 5-HT1A autoreceptors on serotoninergic neurons in the midbrain raphe nuclei. Eur J Neurosci 2:1144\u20131154","journal-title":"Eur J Neurosci"},{"key":"4872_CR185","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/syn.890010103","volume":"1","author":"JS Sprouse","year":"1987","unstructured":"Sprouse JS, Aghajanian GK (1987) Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse 1:3\u20139","journal-title":"Synapse"},{"key":"4872_CR186","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S0960-9822(02)70790-2","volume":"6","author":"V Stambolic","year":"1996","unstructured":"Stambolic V, Ruel L, Woodgett JR (1996) Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol 6:1664\u20131668","journal-title":"Curr Biol"},{"key":"4872_CR187","doi-asserted-by":"crossref","first-page":"7566","DOI":"10.1523\/JNEUROSCI.16-23-07566.1996","volume":"16","author":"IM Stanford","year":"1996","unstructured":"Stanford IM, Lacey MG (1996) Differential actions of serotonin, mediated by 5-HT1B and 5-HT2C receptors, on GABA-mediated synaptic input to rat substantia nigra pars reticulata neurons in vitro. J Neurosci 16:7566\u20137573","journal-title":"J Neurosci"},{"key":"4872_CR188","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0028-3908(94)90069-8","volume":"33","author":"SJ Starkey","year":"1994","unstructured":"Starkey SJ, Skingle M (1994) 5-HT1D as well as 5-HT1A autoreceptors modulate 5-HT release in the guinea-pig dorsal raphe nucleus. Neuropharmacology 33:393\u2013402","journal-title":"Neuropharmacology"},{"key":"4872_CR189","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2006.11.009","volume":"101","author":"JD Steele","year":"2007","unstructured":"Steele JD, Currie J, Lawrie SM, Reid I (2007) Prefrontal cortical functional abnormality in major depressive disorder: a stereotactic meta-analysis. J Affect Disord 101:1\u201311","journal-title":"J Affect Disord"},{"key":"4872_CR190","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.pscychresns.2011.11.001","volume":"202","author":"M Storvik","year":"2012","unstructured":"Storvik M, Hakkinen M, Tupala E, Tiihonen J (2012) Whole-hemisphere autoradiography of 5-HT(1) B receptor densities in postmortem alcoholic brains. Psychiatry Res 202:264\u2013270","journal-title":"Psychiatry Res"},{"key":"4872_CR191","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0006-3223(01)01366-X","volume":"51","author":"HF Sun","year":"2002","unstructured":"Sun HF, Chang YT, Fann CS, Chang CJ, Chen YH, Hsu YP, Yu WY, Cheng AT (2002) Association study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han. Biol Psychiatry 51:896\u2013901","journal-title":"Biol Psychiatry"},{"key":"4872_CR192","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/mp.2014.13","volume":"19","author":"P Svenningsson","year":"2014","unstructured":"Svenningsson P, Berg L, Matthews D, Ionescu DF, Richards EM, Niciu MJ, Malinger A, Toups M, Manji H, Trivedi MH, Zarate CA Jr, Greengard P (2014) Preliminary evidence that early reduction in p11 levels in natural killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram. Mol Psychiatry 19:962\u2013964","journal-title":"Mol Psychiatry"},{"key":"4872_CR193","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.1117571","volume":"311","author":"P Svenningsson","year":"2006","unstructured":"Svenningsson P, Chergui K, Rachleff I, Flajolet M, Zhang X, El Yacoubi M, Vaugeois JM, Nomikos GG, Greengard P (2006) Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 311:77\u201380","journal-title":"Science"},{"key":"4872_CR194","first-page":"615","volume":"54","author":"E Tatarczynska","year":"2002","unstructured":"Tatarczynska E, Klodzinska A, Chojnacka-Wojcik E (2002) Effects of combined administration of 5-HT1A and\/or 5-HT1B receptor antagonists and paroxetine or fluoxetine in the forced swimming test in rats. Pol J Pharmacol 54:615\u2013623","journal-title":"Pol J Pharmacol"},{"key":"4872_CR195","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejphar.2004.01.008","volume":"487","author":"E Tatarczynska","year":"2004","unstructured":"Tatarczynska E, Klodzinska A, Stachowicz K, Chojnacka-Wojcik E (2004a) Effect of combined administration of 5-HT1A or 5-HT1B\/1D receptor antagonists and antidepressants in the forced swimming test. Eur J Pharmacol 487:133\u2013142","journal-title":"Eur J Pharmacol"},{"key":"4872_CR196","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00008877-200412000-00001","volume":"15","author":"E Tatarczynska","year":"2004","unstructured":"Tatarczynska E, Klodzinska A, Stachowicz K, Chojnacka-Wojcik E (2004b) Effects of a selective 5-HT1B receptor agonist and antagonists in animal models of anxiety and depression. Behav Pharmacol 15:523\u2013534","journal-title":"Behav Pharmacol"},{"key":"4872_CR197","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pscychresns.2016.04.016","volume":"253","author":"M Tiger","year":"2016","unstructured":"Tiger M, Farde L, Ruck C, Varrone A, Forsberg A, Lindefors N, Halldin C, Lundberg J (2016) Low serotonin1B receptor binding potential in the anterior cingulate cortex in drug-free patients with recurrent major depressive disorder. Psychiatry Res 253:36\u201342","journal-title":"Psychiatry Res"},{"key":"4872_CR198","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.pscychresns.2014.05.011","volume":"223","author":"M Tiger","year":"2014","unstructured":"Tiger M, Ruck C, Forsberg A, Varrone A, Lindefors N, Halldin C, Farde L, Lundberg J (2014) Reduced 5-HT1B receptor binding in the dorsal brain stem after cognitive behavioural therapy of major depressive disorder. Psychiatry Res 223:164\u2013170","journal-title":"Psychiatry Res"},{"key":"4872_CR199","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0091-3057(00)00232-X","volume":"66","author":"DM Tomkins","year":"2000","unstructured":"Tomkins DM, O'Neill MF (2000) Effect of 5-HT(1B) receptor ligands on self-administration of ethanol in an operant procedure in rats. Pharmacol Biochem Behav 66:129\u2013136","journal-title":"Pharmacol Biochem Behav"},{"issue":"1 The Neurophar","key":"4872_CR200","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1749-6632.1990.tb16870.x","volume":"600","author":"ISTVAN T\u00d6RK","year":"1990","unstructured":"Tork I (1990) Anatomy of the serotonergic system. Ann N Y Acad Sci 600:9\u201334 discussion 34-5","journal-title":"Annals of the New York Academy of Sciences"},{"key":"4872_CR201","first-page":"1139","volume":"192","author":"AC Trillat","year":"1998","unstructured":"Trillat AC, Malagie I, Bourin M, Jacquot C, Hen R, Gardier AM (1998) Homozygote mice deficient in serotonin 5-HT1B receptor and antidepressant effect of selective serotonin reuptake inhibitors. C R Seances Soc Biol Fil 192:1139\u20131147","journal-title":"C R Seances Soc Biol Fil"},{"key":"4872_CR202","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1093\/emboj\/cdg162","volume":"22","author":"SF Graaf van de","year":"2003","unstructured":"van de Graaf SF, Hoenderop JG, Gkika D, Lamers D, Prenen J, Rescher U, Gerke V, Staub O, Nilius B, Bindels RJ (2003) Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex. EMBO J 22:1478\u20131487","journal-title":"EMBO J"},{"key":"4872_CR203","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0006-8993(01)02823-2","volume":"915","author":"K Varnas","year":"2001","unstructured":"Varnas K, Hall H, Bonaventure P, Sedvall G (2001) Autoradiographic mapping of 5-HT(1B) and 5-HT(1D) receptors in the post mortem human brain using [(3)H]GR 125743. Brain Res 915:47\u201357","journal-title":"Brain Res"},{"key":"4872_CR204","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/hbm.20035","volume":"22","author":"K Varnas","year":"2004","unstructured":"Varnas K, Halldin C, Hall H (2004) Autoradiographic distribution of serotonin transporters and receptor subtypes in human brain. Hum Brain Mapp 22:246\u2013260","journal-title":"Hum Brain Mapp"},{"key":"4872_CR205","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/syn.20128","volume":"56","author":"K Varnas","year":"2005","unstructured":"Varnas K, Hurd YL, Hall H (2005) Regional expression of 5-HT1B receptor mRNA in the human brain. Synapse 56:21\u201328","journal-title":"Synapse"},{"key":"4872_CR206","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/jcbfm.2010.55","volume":"31","author":"K Varnas","year":"2011","unstructured":"Varnas K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Soderstrom J, Farde L (2011) Quantitative analysis of [11C]AZ10419369 binding to 5-HT1B receptors in human brain. J Cereb Blood Flow Metab 31:113\u2013123","journal-title":"J Cereb Blood Flow Metab"},{"key":"4872_CR207","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1523\/JNEUROSCI.5343-08.2009","volume":"29","author":"JL Warner-Schmidt","year":"2009","unstructured":"Warner-Schmidt JL, Flajolet M, Maller A, Chen EY, Qi H, Svenningsson P, Greengard P (2009) Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation. J Neurosci 29:1937\u20131946","journal-title":"J Neurosci"},{"key":"4872_CR208","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1073\/pnas.89.8.3630","volume":"89","author":"RL Weinshank","year":"1992","unstructured":"Weinshank RL, Zgombick JM, Macchi MJ, Branchek TA, Hartig PR (1992) Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. Proc Natl Acad Sci U S A 89:3630\u20133634","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4872_CR209","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.euroneuro.2017.02.011","volume":"27","author":"ER Veldman","year":"2017","unstructured":"Veldman ER, Svedberg MM, Svenningsson P, Lundberg J (2017) Distribution and levels of 5-HT1B receptors in anterior cingulate cortex of patients with bipolar disorder, major depressive disorder and schizophrenia\u2014an autoradiography study. Eur Neuropsychopharmacol 27:504\u2013514","journal-title":"Eur Neuropsychopharmacol"},{"key":"4872_CR210","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1192\/bjp.178.5.454","volume":"178","author":"R Whale","year":"2001","unstructured":"Whale R, Clifford EM, Bhagwagar Z, Cowen PJ (2001) Decreased sensitivity of 5-HT(1D) receptors in melancholic depression. Br J Psychiatry 178:454\u2013457","journal-title":"Br J Psychiatry"},{"key":"4872_CR211","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0140-6736(13)61611-6","volume":"382","author":"HA Whiteford","year":"2013","unstructured":"Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE, Charlson FJ, Norman RE, Flaxman AD, Johns N, Burstein R, Murray CJ, Vos T (2013) Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet 382:1575\u20131586","journal-title":"Lancet"},{"key":"4872_CR212","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/YPG.0b013e32832a506e","volume":"19","author":"SM Villafuerte","year":"2009","unstructured":"Villafuerte SM, Vallabhaneni K, Sliwerska E, McMahon FJ, Young EA, Burmeister M (2009) SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A. Psychiatr Genet 19:281\u2013291","journal-title":"Psychiatr Genet"},{"key":"4872_CR213","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1073\/pnas.1524183113","volume":"113","author":"MS Virk","year":"2016","unstructured":"Virk MS, Sagi Y, Medrihan L, Leung J, Kaplitt MG, Greengard P (2016) Opposing roles for serotonin in cholinergic neurons of the ventral and dorsal striatum. Proc Natl Acad Sci U S A 113:734\u2013739","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4872_CR214","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00213-013-2985-0","volume":"227","author":"NS Woehrle","year":"2013","unstructured":"Woehrle NS, Klenotich SJ, Jamnia N, Ho EV, Dulawa SC (2013) Effects of chronic fluoxetine treatment on serotonin 1B receptor-induced deficits in delayed alternation. Psychopharmacology 227:545\u2013551","journal-title":"Psychopharmacology"},{"key":"4872_CR215","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbr.2014.08.065","volume":"277","author":"JP Voigt","year":"2015","unstructured":"Voigt JP, Fink H (2015) Serotonin controlling feeding and satiety. Behav Brain Res 277:14\u201331","journal-title":"Behav Brain Res"},{"key":"4872_CR216","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1002\/j.1460-2075.1991.tb04977.x","volume":"10","author":"MM Voigt","year":"1991","unstructured":"Voigt MM, Laurie DJ, Seeburg PH, Bach A (1991) Molecular cloning and characterization of a rat brain cDNA encoding a 5-hydroxytryptamine1B receptor. EMBO J 10:4017\u20134023","journal-title":"EMBO J"},{"key":"4872_CR217","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2013.112","volume":"4","author":"H Yamanaka","year":"2014","unstructured":"Yamanaka H, Yokoyama C, Mizuma H, Kurai S, Finnema SJ, Halldin C, Doi H, Onoe H (2014) A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques. Transl Psychiatry 4:e342","journal-title":"Transl Psychiatry"},{"key":"4872_CR218","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.brainres.2004.06.053","volume":"1021","author":"QS Yan","year":"2004","unstructured":"Yan QS, Zheng SZ, Yan SE (2004) Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis. Brain Res 1021:82\u201391","journal-title":"Brain Res"},{"key":"4872_CR219","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1124\/jpet.110.174433","volume":"339","author":"M Zhang","year":"2011","unstructured":"Zhang M, Zhou D, Wang Y, Maier DL, Widzowski DV, Sobotka-Briner CD, Brockel BJ, Potts WM, Shenvi AB, Bernstein PR, Pierson ME (2011) Preclinical pharmacology and pharmacokinetics of AZD3783, a selective 5-hydroxytryptamine 1B receptor antagonist. J Pharmacol Exp Ther 339:567\u2013578","journal-title":"J Pharmacol Exp Ther"},{"key":"4872_CR220","doi-asserted-by":"crossref","first-page":"52S","DOI":"10.1016\/S0893-133X(99)00047-0","volume":"21","author":"X Zhuang","year":"1999","unstructured":"Zhuang X, Gross C, Santarelli L, Compan V, Trillat AC, Hen R (1999) Altered emotional states in knockout mice lacking 5-HT1A or 5-HT1B receptors. Neuropsychopharmacology 21:52S\u201360S","journal-title":"Neuropsychopharmacology"},{"key":"4872_CR221","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/jlcr.3001","volume":"56","author":"L Zimmer","year":"2013","unstructured":"Zimmer L, Le Bars D (2013) Current status of positron emission tomography radiotracers for serotonin receptors in humans. J Labelled Comp Radiopharm 56:105\u2013113","journal-title":"J Labelled Comp Radiopharm"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-018-4872-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-018-4872-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-018-4872-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T16:35:10Z","timestamp":1751474110000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-018-4872-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,15]]},"references-count":221,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["4872"],"URL":"https:\/\/doi.org\/10.1007\/s00213-018-4872-1","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,15]]},"assertion":[{"value":"26 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}