{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:16:14Z","timestamp":1786979774071,"version":"build-2736575974"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100007136","name":"Secretar\u00eda de Estado de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SAF2016-75347R"],"award-info":[{"award-number":["SAF2016-75347R"]}],"id":[{"id":"10.13039\/501100007136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Servicios Sociales e Igualdad","doi-asserted-by":"publisher","award":["2014I020"],"award-info":[{"award-number":["2014I020"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003751","name":"Ministerio de Sanidad, Servicios Sociales e Igualdad","doi-asserted-by":"publisher","award":["2016I004"],"award-info":[{"award-number":["2016I004"]}],"id":[{"id":"10.13039\/501100003751","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00213-018-5052-z","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T22:56:18Z","timestamp":1538607378000},"page":"925-938","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effects of MDPV on dopamine transporter regulation in male rats. Comparison with cocaine"],"prefix":"10.1007","volume":"236","author":[{"given":"Raul","family":"Lopez-Arnau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Duart-Castells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Aster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Camarasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Escubedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6627-4501","authenticated-orcid":false,"given":"David","family":"Pubill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,10,4]]},"reference":[{"key":"5052_CR1","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.neuropharm.2013.04.003","volume":"71","author":"SM Aarde","year":"2013","unstructured":"Aarde SM, Huang PK, Creehan KM, Dickerson TJ, Taffe MA (2013) The novel recreational drug 3,4-methylenedioxypyrovalerone (MDPV) is a potent psychomotor stimulant: self-administration and locomotor activity in rats. Neuropharmacology 71:130\u2013140. \n                    https:\/\/doi.org\/10.1016\/j.neuropharm.2013.04.003","journal-title":"Neuropharmacology"},{"key":"5052_CR2","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1111\/j.1460-9568.2009.06907.x","volume":"30","author":"V Aliane","year":"2009","unstructured":"Aliane V, P\u00e9rez S, Nieoullon A, Deniau JM, Kemel ML (2009) Cocaine-induced stereotypy is linked to an imbalance between the medial prefrontal and sensorimotor circuits of the basal ganglia. Eur J Neurosci 30:1269\u20131279. \n                    https:\/\/doi.org\/10.1111\/j.1460-9568.2009.06907.x","journal-title":"Eur J Neurosci"},{"key":"5052_CR3","doi-asserted-by":"publisher","unstructured":"Alvarez J-C, Fabresse N, Larabi IA (2017) Prevalence and surveillance of synthetic cathinones use by hair analysis: an update review. Curr Pharm Des 23:5487\u20135495. \n                    https:\/\/doi.org\/10.2174\/1381612823666170704124156","DOI":"10.2174\/1381612823666170704124156"},{"key":"5052_CR4","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.chemosphere.2016.10.107","volume":"168","author":"R Bade","year":"2017","unstructured":"Bade R, Bijlsma L, Sancho JV et al (2017) Liquid chromatography-tandem mass spectrometry determination of synthetic cathinones and phenethylamines in influent wastewater of eight European cities. Chemosphere 168:1032\u20131041. \n                    https:\/\/doi.org\/10.1016\/j.chemosphere.2016.10.107","journal-title":"Chemosphere"},{"key":"5052_CR5","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/npp.2012.204","volume":"38","author":"MH Baumann","year":"2013","unstructured":"Baumann MH, Partilla JS, Lehner KR, Thorndike EB, Hoffman AF, Holy M, Rothman RB, Goldberg SR, Lupica CR, Sitte HH, Brandt SD, Tella SR, Cozzi NV, Schindler CW (2013) Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive \u2018Bath Salts\u2019 products. Neuropsychopharmacology 38:552\u2013562. \n                    https:\/\/doi.org\/10.1038\/npp.2012.204","journal-title":"Neuropsychopharmacology"},{"key":"5052_CR6","first-page":"1316","volume":"290","author":"BP Bowman","year":"1999","unstructured":"Bowman BP, Vaughan SR, Walker QD et al (1999) Effects of sex and gonadectomy on cocaine metabolism in the rat. J Pharmacol Exp Ther 290:1316\u20131323","journal-title":"J Pharmacol Exp Ther"},{"key":"5052_CR7","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1177\/0269881116645300","volume":"30","author":"M Buenrostro-J\u00e1uregui","year":"2016","unstructured":"Buenrostro-J\u00e1uregui M, Ciudad-Roberts A, Moreno J, Mu\u00f1oz-Villegas P, L\u00f3pez-Arnau R, Pubill D, Escubedo E, Camarasa J (2016) Changes in CREB and deltaFosB are associated with the behavioural sensitization induced by methylenedioxypyrovalerone. J Psychopharmacol 30:707\u2013712. \n                    https:\/\/doi.org\/10.1177\/0269881116645300","journal-title":"J Psychopharmacol"},{"key":"5052_CR8","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s00213-013-2967-2","volume":"227","author":"K Cameron","year":"2013","unstructured":"Cameron K, Kolanos R, Verkariya R, de Felice L, Glennon RA (2013) Mephedrone and methylenedioxypyrovalerone (MDPV), major constituents of \u201cbath salts,\u201d produce opposite effects at the human dopamine transporter. Psychopharmacology 227:493\u2013499. \n                    https:\/\/doi.org\/10.1007\/s00213-013-2967-2","journal-title":"Psychopharmacology"},{"key":"5052_CR9","doi-asserted-by":"publisher","first-page":"40442","DOI":"10.1074\/jbc.M501969200","volume":"280","author":"MA Cervinski","year":"2005","unstructured":"Cervinski MA, Foster JD, Vaughan RA (2005) Psychoactive substrates stimulate dopamine transporter phosphorylation and down-regulation by cocaine-sensitive and protein kinase C-dependent mechanisms. J Biol Chem 280:40442\u201340449. \n                    https:\/\/doi.org\/10.1074\/jbc.M501969200","journal-title":"J Biol Chem"},{"key":"5052_CR10","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.neuropharm.2006.05.032","volume":"51","author":"C Chipana","year":"2006","unstructured":"Chipana C, Camarasa J, Pubill D, Escubedo E (2006) Protection against MDMA-induced dopaminergic neurotoxicity in mice by methyllycaconitine: involvement of nicotinic receptors. Neuropharmacology 51:885\u2013895. \n                    https:\/\/doi.org\/10.1016\/j.neuropharm.2006.05.032","journal-title":"Neuropharmacology"},{"key":"5052_CR11","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.neuint.2007.07.016","volume":"52","author":"C Chipana","year":"2008","unstructured":"Chipana C, Garc\u00eda-Rat\u00e9s S, Camarasa J, Pubill D, Escubedo E (2008) Different oxidative profile and nicotinic receptor interaction of amphetamine and 3,4-methylenedioxy-methamphetamine. Neurochem Int 52:401\u2013410. \n                    https:\/\/doi.org\/10.1016\/j.neuint.2007.07.016","journal-title":"Neurochem Int"},{"key":"5052_CR12","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.neuropharm.2018.04.031","volume":"137","author":"LM Colon-Perez","year":"2018","unstructured":"Colon-Perez LM, Pino JA, Saha K, Pompilus M, Kaplitz S, Choudhury N, Jagnarine DA, Geste JR, Levin BA, Wilks I, Setlow B, Bruijnzeel AW, Khoshbouei H, Torres GE, Febo M (2018) Functional connectivity, behavioral and dopaminergic alterations 24 hours following acute exposure to synthetic bath salt drug methylenedioxypyrovalerone. Neuropharmacology 137:178\u2013193. \n                    https:\/\/doi.org\/10.1016\/j.neuropharm.2018.04.031","journal-title":"Neuropharmacology"},{"key":"5052_CR13","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/BF00422974","volume":"39","author":"I Creese","year":"1974","unstructured":"Creese I, Iversen SD (1974) The role of forebrain dopamine systems in amphetamine induced stereotyped behavior in the rat. Psychopharmacologia 39:345\u2013357","journal-title":"Psychopharmacologia"},{"key":"5052_CR14","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1006\/bbrc.2002.6384","volume":"290","author":"LC Daws","year":"2002","unstructured":"Daws LC, Callaghan PD, Mor\u00f3n JA, Kahlig KM, Shippenberg TS, Javitch JA, Galli A (2002) Cocaine increases dopamine uptake and cell surface expression of dopamine transporters. Biochem Biophys Res Commun 290:1545\u20131550. \n                    https:\/\/doi.org\/10.1006\/bbrc.2002.6384","journal-title":"Biochem Biophys Res Commun"},{"key":"5052_CR15","unstructured":"Duart-Castells L, Buenrostro-Ja\u0301uregui M, Mu\u00f1oz-Villegas P et al (2017) Repeated exposure of adolescent mice to 3,4-methylenedioxypyrovalerone activates transcriptional mechanisms that persist until adulthood and are similar to those activated by cocaine. Poster communication at Neuroscience 2017 Meeting. \n                    http:\/\/www.abstractsonline.com\/pp8\/index.html#!\/4376\/presentation\/29714\n                    \n                  . Accessed Date: October 1 2018."},{"key":"5052_CR16","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1124\/jpet.105.089748","volume":"315","author":"E Escubedo","year":"2005","unstructured":"Escubedo E, Chipana C, P\u00e9rez-S\u00e1nchez M et al (2005) Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptors. J Pharmacol Exp Ther 315:658\u2013667. \n                    https:\/\/doi.org\/10.1124\/jpet.105.089748","journal-title":"J Pharmacol Exp Ther"},{"key":"5052_CR17","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/0006-8993(92)90252-5","volume":"578","author":"GM Farfel","year":"1992","unstructured":"Farfel GM, Kleven MS, Woolverton WL, Seiden LS, Perry BD (1992) Effects of repeated injections of cocaine on catecholamine receptor binding sites, dopamine transporter binding sites and behavior in rhesus monkey. Brain Res 578:235\u2013243","journal-title":"Brain Res"},{"key":"5052_CR18","first-page":"834","volume":"282","author":"AE Fleckenstein","year":"1997","unstructured":"Fleckenstein AE, Metzger RR, Wilkins DG et al (1997) Rapid and reversible effects of methamphetamine on dopamine transporters. J Pharmacol Exp Ther 282:834\u2013838","journal-title":"J Pharmacol Exp Ther"},{"key":"5052_CR19","doi-asserted-by":"publisher","unstructured":"Garcia-Rat\u00e9s S, Camarasa J, Escubedo E, Pubill David (2007) Methamphetamine and 3,4-methylenedioxymethamphetamine interact with central nicotinic receptors and induce their up-regulation. Toxicol Appl Pharmacol 223(3):195\u2013205. \n                    https:\/\/doi.org\/10.1016\/j.taap.2007.05.015","DOI":"10.1016\/j.taap.2007.05.015"},{"key":"5052_CR20","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1097\/FBP.0b013e328364166d","volume":"24","author":"MB Gatch","year":"2013","unstructured":"Gatch MB, Taylor CM, Forster MJ (2013) Locomotor stimulant and discriminative stimulus effects of \u201cbath salt\u201d cathinones. Behav Pharmacol 24:437\u2013447. \n                    https:\/\/doi.org\/10.1097\/FBP.0b013e328364166d","journal-title":"Behav Pharmacol"},{"key":"5052_CR21","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/syn.10223","volume":"49","author":"CT Giambalvo","year":"2003","unstructured":"Giambalvo CT (2003) Differential effects of amphetamine transport vs. dopamine reverse transport on particulate PKC activity in striatal synaptoneurosomes. Synapse 49:125\u2013133. \n                    https:\/\/doi.org\/10.1002\/syn.10223","journal-title":"Synapse"},{"key":"5052_CR22","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1073\/pnas.73.7.2424","volume":"73","author":"LA Greene","year":"1976","unstructured":"Greene LA, Tischler AS (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci U S A 73:2424\u20132428","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5052_CR23","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1097\/FBP.0000000000000006","volume":"24","author":"RA Gregg","year":"2013","unstructured":"Gregg RA, Tallarida CS, Reitz AB, Rawls SM (2013) Mephedrone interactions with cocaine: prior exposure to the \u2018bath salt\u2019 constituent enhances cocaine-induced locomotor activation in rats. Behav Pharmacol 24:684\u2013688. \n                    https:\/\/doi.org\/10.1097\/FBP.0000000000000006","journal-title":"Behav Pharmacol"},{"key":"5052_CR24","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.neuropharm.2016.04.014","volume":"108","author":"RA Gregg","year":"2016","unstructured":"Gregg RA, Hicks C, Nayak SU, Tallarida CS, Nucero P, Smith GR, Reitz AB, Rawls SM (2016) Synthetic cathinone MDPV downregulates glutamate transporter subtype I (GLT-1) and produces rewarding and locomotor-activating effects that are reduced by a GLT-1 activator. Neuropharmacology 108:111\u2013119. \n                    https:\/\/doi.org\/10.1016\/j.neuropharm.2016.04.014","journal-title":"Neuropharmacology"},{"key":"5052_CR25","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/BF02098505","volume":"68","author":"N Haberland","year":"1987","unstructured":"Haberland N, Hetey L (1987) Studies in postmortem dopamine uptake. II Alterations of the synaptosomal catecholamine uptake in postmortem brain regions in schizophrenia. J Neural Transm 68:303\u2013313","journal-title":"J Neural Transm"},{"key":"5052_CR26","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1124\/jpet.300.3.1093","volume":"300","author":"JP Hansen","year":"2002","unstructured":"Hansen JP, Riddle EL, Sandoval V et al (2002) Methylenedioxymethamphetamine decreases plasmalemmal and vesicular dopamine transport: mechanisms and implications for neurotoxicity. J Pharmacol Exp Ther 300:1093\u20131100","journal-title":"J Pharmacol Exp Ther"},{"key":"5052_CR27","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0006-8993(00)02094-1","volume":"863","author":"HM Haughey","year":"2000","unstructured":"Haughey HM, Brown JM, Wilkins DG, Hanson GR, Fleckenstein AE (2000) Differential effects of methamphetamine on Na(+)\/Cl(\u2212)-dependent transporters. Brain Res 863:59\u201365","journal-title":"Brain Res"},{"key":"5052_CR28","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/0006-8993(90)90797-F","volume":"531","author":"S Izenwasser","year":"1990","unstructured":"Izenwasser S, Cox BM (1990) Daily cocaine treatment produces a persistent reduction of [3H]dopamine uptake in vitro in rat nucleus accumbens but not in striatum. Brain Res 531:338\u2013341","journal-title":"Brain Res"},{"key":"5052_CR29","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1080\/02791072.2014.962717","volume":"46","author":"PS Johnson","year":"2014","unstructured":"Johnson PS, Johnson MW (2014) Investigation \u201cbath salts\u201d use patterns within an online sample of users in the United States. J Psychoactive Drugs 46:369\u2013378. \n                    https:\/\/doi.org\/10.1080\/02791072.2014.962717","journal-title":"J Psychoactive Drugs"},{"key":"5052_CR30","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.neuropharm.2005.08.018","volume":"49","author":"LA Johnson","year":"2005","unstructured":"Johnson LA, Furman CA, Zhang M et al (2005) Rapid delivery of the dopamine transporter to the plasmalemmal membrane upon amphetamine stimulation. Neuropharmacology 49:750\u2013758. \n                    https:\/\/doi.org\/10.1016\/j.neuropharm.2005.08.018","journal-title":"Neuropharmacology"},{"key":"5052_CR31","doi-asserted-by":"publisher","first-page":"e17757","DOI":"10.1371\/journal.pone.0017757","volume":"6","author":"MP Kashyap","year":"2011","unstructured":"Kashyap MP, Singh AK, Kumar V, Tripathi VK, Srivastava RK, Agrawal M, Khanna VK, Yadav S, Jain SK, Pant AB (2011) Monocrotophos induced apoptosis in PC12 cells: role of xenobiotic metabolizing cytochrome P450s. PLoS One 6:e17757. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0017757","journal-title":"PLoS One"},{"key":"5052_CR32","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1111\/1556-4029.12202","volume":"58","author":"K Kesha","year":"2013","unstructured":"Kesha K, Boggs CL, Ripple MG, Allan CH, Levine B, Jufer-Phipps R, Doyon S, Chi PL, Fowler DR (2013) Methylenedioxypyrovalerone (\u201cbath salts\u201d), related death: case report and review of the literature. J Forensic Sci 58:1654\u20131659. \n                    https:\/\/doi.org\/10.1111\/1556-4029.12202","journal-title":"J Forensic Sci"},{"key":"5052_CR33","first-page":"181","volume":"286","author":"B Kittner","year":"1987","unstructured":"Kittner B, Br\u00e4utigam M, Herken H (1987) PC12 cells: a model system for studying drug effects on dopamine synthesis and release. Arch Int Pharmacodyn Ther 286:181\u2013194","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"5052_CR34","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1021\/cn4001236","volume":"4","author":"R Kolanos","year":"2013","unstructured":"Kolanos R, Solis E, Sakloth F et al (2013) \u201cDeconstruction\u201d of the abused synthetic cathinone methylenedioxypyrovalerone (MDPV) and an examination of effects at the human dopamine transporter. ACS Chem Neurosci 4:1524\u20131529. \n                    https:\/\/doi.org\/10.1021\/cn4001236","journal-title":"ACS Chem Neurosci"},{"key":"5052_CR35","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/S0006-8993(96)01384-4","volume":"750","author":"SR Letchworth","year":"1997","unstructured":"Letchworth SR, Daunais JB, Hedgecock AA, Porrino LJ (1997) Effects of chronic cocaine administration on dopamine transporter mRNA and protein in the rat. Brain Res 750:214\u2013222","journal-title":"Brain Res"},{"key":"5052_CR36","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1176\/ajp.156.2.238","volume":"156","author":"KY Little","year":"1999","unstructured":"Little KY, Zhang L, Desmond T et al (1999) Striatal dopaminergic abnormalities in human cocaine users. Am J Psychiatry 156:238\u2013245. \n                    https:\/\/doi.org\/10.1176\/ajp.156.2.238","journal-title":"Am J Psychiatry"},{"key":"5052_CR37","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1124\/mol.61.2.436","volume":"61","author":"KY Little","year":"2002","unstructured":"Little KY, Elmer LW, Zhong H et al (2002) Cocaine induction of dopamine transporter trafficking to the plasma membrane. Mol Pharmacol 61:436\u2013445","journal-title":"Mol Pharmacol"},{"key":"5052_CR38","doi-asserted-by":"publisher","first-page":"22168","DOI":"10.1074\/jbc.M301845200","volume":"278","author":"MK Loder","year":"2003","unstructured":"Loder MK, Melikian HE (2003) The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines. J Biol Chem 278:22168\u201322174. \n                    https:\/\/doi.org\/10.1074\/jbc.M301845200","journal-title":"J Biol Chem"},{"key":"5052_CR39","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1111\/ejn.13357","volume":"45","author":"KM Lohr","year":"2017","unstructured":"Lohr KM, Masoud ST, Salahpour A, Miller GW (2017) Membrane transporters as mediators of synaptic dopamine dynamics: implications for disease. Eur J Neurosci 45:20\u201333. \n                    https:\/\/doi.org\/10.1111\/ejn.13357","journal-title":"Eur J Neurosci"},{"key":"5052_CR40","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1111\/bph.13771","volume":"174","author":"R L\u00f3pez-Arnau","year":"2017","unstructured":"L\u00f3pez-Arnau R, Luj\u00e1n MA, Duart-Castells L, Pubill D, Camarasa J, Valverde O, Escubedo E (2017) Exposure of adolescent mice to 3,4-methylenedioxypyrovalerone increases the psychostimulant, rewarding and reinforcing effects of cocaine in adulthood. Br J Pharmacol 174:1161\u20131173. \n                    https:\/\/doi.org\/10.1111\/bph.13771","journal-title":"Br J Pharmacol"},{"key":"5052_CR41","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1046\/j.1471-4159.2002.00820.x","volume":"81","author":"DC Mash","year":"2002","unstructured":"Mash DC, Pablo J, Ouyang Q, Hearn WL, Izenwasser S (2002) Dopamine transport function is elevated in cocaine users. J Neurochem 81:292\u2013300","journal-title":"J Neurochem"},{"key":"5052_CR42","unstructured":"NIDA (2018) Synthetic Cathinones (\"Bath Salts\"). \n                    https:\/\/www.drugabuse.gov\/publications\/drugfacts\/synthetic-cathinones-bath-salts\n                    \n                  . Accessed October 1 2018"},{"key":"5052_CR43","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1177\/0269881115598415","volume":"29","author":"J Novellas","year":"2015","unstructured":"Novellas J, L\u00f3pez-Arnau R, Carb\u00f3 ML et al (2015) Concentrations of MDPV in rat striatum correlate with the psychostimulant effect. J Psychopharmacol 29:1209\u20131918. \n                    https:\/\/doi.org\/10.1177\/0269881115598415","journal-title":"J Psychopharmacol"},{"key":"5052_CR44","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/j.1476-5381.2009.00522.x","volume":"159","author":"I Peraile","year":"2010","unstructured":"Peraile I, Torres E, Mayado A, Izco M, Lopez-Jimenez A, Lopez-Moreno JA, Colado MI, O'Shea E (2010) Dopamine transporter down-regulation following repeated cocaine: implications for 3,4-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice. Br J Pharmacol 159:201\u2013211. \n                    https:\/\/doi.org\/10.1111\/j.1476-5381.2009.00522.x","journal-title":"Br J Pharmacol"},{"key":"5052_CR45","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/S0165-0173(97)00021-0","volume":"25","author":"RC Pierce","year":"1997","unstructured":"Pierce RC, Kalivas PW (1997) A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Res Brain Res Rev 25:192\u2013216","journal-title":"Brain Res Brain Res Rev"},{"key":"5052_CR46","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s00213-012-2679-z","volume":"223","author":"LM Pritchard","year":"2012","unstructured":"Pritchard LM, Hensleigh E, Lynch S (2012) Altered locomotor and stereotyped responses to acute methamphetamine in adolescent, maternally separated rats. Psychopharmacology 223:27\u201335. \n                    https:\/\/doi.org\/10.1007\/s00213-012-2679-z","journal-title":"Psychopharmacology"},{"key":"5052_CR47","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.taap.2004.08.008","volume":"204","author":"D Pubill","year":"2005","unstructured":"Pubill D, Chipana C, Camins A, Pall\u00e0s M, Camarasa J, Escubedo E (2005) Free radical production induced by methamphetamine in rat striatal synaptosomes. Toxicol Appl Pharmacol 204:57\u201368. \n                    https:\/\/doi.org\/10.1016\/j.taap.2004.08.008","journal-title":"Toxicol Appl Pharmacol"},{"key":"5052_CR48","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.pharmthera.2010.09.009","volume":"129","author":"S Ramamoorthy","year":"2011","unstructured":"Ramamoorthy S, Shippenberg TS, Jayanthi LD (2011) Regulation of monoamine transporters: role of transporter phosphorylation. Pharmacol Ther 129:220\u2013238. \n                    https:\/\/doi.org\/10.1016\/j.pharmthera.2010.09.009","journal-title":"Pharmacol Ther"},{"key":"5052_CR49","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"S Reagan-Shaw","year":"2008","unstructured":"Reagan-Shaw S, Nihal M, Ahmad N (2008) Dose translation from animal to human studies revisited. FASEB J 22:659\u2013661. \n                    https:\/\/doi.org\/10.1096\/fj.07-9574LSF","journal-title":"FASEB J"},{"key":"5052_CR50","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1126\/science.2820058","volume":"237","author":"MC Ritz","year":"1987","unstructured":"Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ (1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 237:1219\u20131223","journal-title":"Science"},{"key":"5052_CR51","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0165-0173(93)90013-P","volume":"18","author":"TE Robinson","year":"1993","unstructured":"Robinson TE, Berridge KC (1993) The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 18:247\u2013291","journal-title":"Brain Res Brain Res Rev"},{"key":"5052_CR52","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1124\/jpet.107.130534","volume":"325","author":"DJ Samuvel","year":"2008","unstructured":"Samuvel DJ, Jayanthi LD, Manohar S, Kaliyaperumal K, See RE, Ramamoorthy S (2008) Dysregulation of dopamine transporter trafficking and function after abstinence from cocaine self-administration in rats: evidence for differential regulation in caudate putamen and nucleus accumbens. J Pharmacol Exp Ther 325:293\u2013301. \n                    https:\/\/doi.org\/10.1124\/jpet.107.130534","journal-title":"J Pharmacol Exp Ther"},{"key":"5052_CR53","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1523\/JNEUROSCI.21-04-01413.2001","volume":"21","author":"V Sandoval","year":"2001","unstructured":"Sandoval V, Riddle EL, Ugarte YV, Hanson GR, Fleckenstein AE (2001) Methamphetamine-induced rapid and reversible changes in dopamine transporter function: an in vitro model. J Neurosci 21:1413\u20131419","journal-title":"J Neurosci"},{"key":"5052_CR54","doi-asserted-by":"publisher","first-page":"6850","DOI":"10.1073\/pnas.110035297","volume":"97","author":"C Saunders","year":"2000","unstructured":"Saunders C, Ferrer JV, Shi L, Chen J, Merrill G, Lamb ME, Leeb-Lundberg LMF, Carvelli L, Javitch JA, Galli A (2000) Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. Proc Natl Acad Sci U S A 97:6850\u20136855. \n                    https:\/\/doi.org\/10.1073\/pnas.110035297","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5052_CR55","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1111\/j.1749-6632.2009.05148.x","volume":"1187","author":"KC Schmitt","year":"2010","unstructured":"Schmitt KC, Reith MEA (2010) Regulation of the dopamine transporter: aspects relevant to psychostimulant drugs of abuse. Ann N Y Acad Sci 1187:316\u2013340. \n                    https:\/\/doi.org\/10.1111\/j.1749-6632.2009.05148.x","journal-title":"Ann N Y Acad Sci"},{"key":"5052_CR56","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1080\/15563650.2017.1353094","volume":"56","author":"S Schmoll","year":"2017","unstructured":"Schmoll S, Romanek K, Stich R, Bekka E, Stenzel J, Geith S, Eyer F, Rabe C (2017) An internet-based survey of 96 German-speaking users of \u201cbath salts\u201d: frequent complications, risky sexual behavior, violence, and delinquency. Clin Toxicol 56:219\u2013222. \n                    https:\/\/doi.org\/10.1080\/15563650.2017.1353094","journal-title":"Clin Toxicol"},{"key":"5052_CR57","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jchemneu.2017.01.004","volume":"83\u201384","author":"A Shekar","year":"2017","unstructured":"Shekar A, Aguilar JI, Galli G, Cozzi NV, Brandt SD, Ruoho AE, Baumann MH, Matthies HJG, Galli A (2017) Atypical dopamine efflux caused by 3,4-methylenedioxypyrovalerone (MDPV) via the human dopamine transporter. J Chem Neuroanat 83\u201384:69\u201374. \n                    https:\/\/doi.org\/10.1016\/j.jchemneu.2017.01.004","journal-title":"J Chem Neuroanat"},{"key":"5052_CR58","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1111\/j.1476-5381.2012.02145.x","volume":"168","author":"L Simmler","year":"2013","unstructured":"Simmler L, Buser T, Donzelli M, Schramm Y, Dieu LH, Huwyler J, Chaboz S, Hoener MC, Liechti ME (2013) Pharmacological characterization of designer cathinones in vitro. Br J Pharmacol 168:458\u2013470. \n                    https:\/\/doi.org\/10.1111\/j.1476-5381.2012.02145.x","journal-title":"Br J Pharmacol"},{"key":"5052_CR59","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1590\/1414-431X20143627","volume":"47","author":"MF Souza","year":"2014","unstructured":"Souza MF, Couto-Pereira NS, Freese L, Costa PA, Caletti G, Bisognin KM, Nin MS, Gomez R, Barros HMT (2014) Behavioral effects of endogenous or exogenous estradiol and progesterone on cocaine sensitization in female rats. Brazilian J Med Biol Res = Rev Bras Pesqui medicas e Biol 47:505\u2013514","journal-title":"Brazilian J Med Biol Res = Rev Bras Pesqui medicas e Biol"},{"key":"5052_CR60","first-page":"1678","volume":"271","author":"JK Staley","year":"1994","unstructured":"Staley JK, Hearn WL, Ruttenber AJ et al (1994) High affinity cocaine recognition sites on the dopamine transporter are elevated in fatal cocaine overdose victims. J Pharmacol Exp Ther 271:1678\u20131685","journal-title":"J Pharmacol Exp Ther"},{"key":"5052_CR61","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S0166-2236(03)00063-8","volume":"26","author":"D Sulzer","year":"2003","unstructured":"Sulzer D, Galli A (2003) Dopamine transport currents are promoted from curiosity to physiology. Trends Neurosci 26:173\u2013176. \n                    https:\/\/doi.org\/10.1016\/S0166-2236(03)00063-8","journal-title":"Trends Neurosci"},{"key":"5052_CR62","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/nrn1008","volume":"4","author":"GE Torres","year":"2003","unstructured":"Torres GE, Gainetdinov RR, Caron MG (2003) Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci 4:13\u201325. \n                    https:\/\/doi.org\/10.1038\/nrn1008","journal-title":"Nat Rev Neurosci"},{"key":"5052_CR63","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1093\/cercor\/10.5.488","volume":"10","author":"TM Tzschentke","year":"2000","unstructured":"Tzschentke TM, Schmidt WJ (2000) Differential effects of discrete subarea-specific lesions of the rat medial prefrontal cortex on amphetamine- and cocaine-induced behavioural sensitization. Cereb Cortex 10:488\u2013498","journal-title":"Cereb Cortex"},{"key":"5052_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4303\/jdar\/235967","volume":"235967","author":"LR Watterson","year":"2016","unstructured":"Watterson LR, Kufahl PR, Taylor SB, Nemirovsky NE, Olive MF (2016) Sensitization to the motor stimulant effects of 3,4-methylenedioxypyrovalerone (MDPV) and cross-sensitization to methamphetamine in rats. J Drug Alcohol Res 235967:1\u201310. \n                    https:\/\/doi.org\/10.4303\/jdar\/235967","journal-title":"J Drug Alcohol Res"},{"key":"5052_CR65","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.1523\/JNEUROSCI.16-10-03507.1996","volume":"16","author":"JM Wilson","year":"1996","unstructured":"Wilson JM, Kish SJ (1996) The vesicular monoamine transporter, in contrast to the dopamine transporter, is not altered by chronic cocaine self-administration in the rat. J Neurosci 16:3507\u20133510","journal-title":"J Neurosci"},{"key":"5052_CR66","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.1111\/1556-4029.12260","volume":"58","author":"TH Wright","year":"2013","unstructured":"Wright TH, Cline-Parhamovich K, Lajoie D, Parsons L, Dunn M, Ferslew KE (2013) Deaths involving methylenedioxypyrovalerone (MDPV) in upper East Tennessee. J Forensic Sci 58:1558\u20131562. \n                    https:\/\/doi.org\/10.1111\/1556-4029.12260","journal-title":"J Forensic Sci"},{"key":"5052_CR67","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.semcdb.2009.01.004","volume":"20","author":"NR Zahniser","year":"2009","unstructured":"Zahniser NR, Sorkin A (2009) Trafficking of dopamine transporters in psychostimulant actions. Semin Cell Dev Biol 20:411\u2013417. \n                    https:\/\/doi.org\/10.1016\/j.semcdb.2009.01.004","journal-title":"Semin Cell Dev Biol"},{"key":"5052_CR68","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/dta.1365","volume":"5","author":"D Zuba","year":"2013","unstructured":"Zuba D, Byrska B (2013) Prevalence and co-existence of active components of \u2018legal highs. Drug Test Anal 5:420\u2013429. \n                    https:\/\/doi.org\/10.1002\/dta.1365","journal-title":"Drug Test Anal"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-018-5052-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-018-5052-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-018-5052-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T19:13:55Z","timestamp":1570130035000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-018-5052-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,4]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["5052"],"URL":"https:\/\/doi.org\/10.1007\/s00213-018-5052-z","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,4]]},"assertion":[{"value":"30 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The experimental protocols concerning the use of animals in this work were approved by the Animal Ethics Committee of the University of Barcelona under supervision of the Autonomous Government of Catalonia, following the guidelines of the European Communities Council (86\/609\/EEC).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}