{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:06:06Z","timestamp":1792649166720,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32 DA007238"],"award-info":[{"award-number":["T32 DA007238"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s00213-018-5146-7","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T21:26:48Z","timestamp":1545168408000},"page":"2857-2866","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Minocycline does not affect experimental pain or addiction-related outcomes in opioid maintained patients"],"prefix":"10.1007","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0444-6432","authenticated-orcid":false,"given":"Caroline A.","family":"Arout","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Ross","family":"MacLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Compton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Sofuoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"5146_CR1","doi-asserted-by":"crossref","unstructured":"Akg\u0171n E, Lunzer MM, Portoghese P (2018) Combined glia inhibition and opioid receptor agonism afford highly potent analgesics without tolerance ACS chemical neuroscience","DOI":"10.1021\/acschemneuro.8b00323"},{"key":"5146_CR2","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1139\/cjpp-2015-0209","volume":"94","author":"R Arezoomandan","year":"2015","unstructured":"Arezoomandan R, Haghparast A (2015) Administration of the glial cell modulator, minocycline, in the nucleus accumbens attenuated the maintenance and reinstatement of morphine-seeking behavior. Can J Physiol Pharmacol 94:257\u2013264","journal-title":"Can J Physiol Pharmacol"},{"key":"5146_CR3","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s40263-015-0255-x","volume":"29","author":"CA Arout","year":"2015","unstructured":"Arout CA, Edens E, Petrakis IL, Sofuoglu M (2015) Targeting opioid-induced hyperalgesia in clinical treatment: neurobiological considerations. CNS drugs 29:465\u2013486","journal-title":"CNS drugs"},{"key":"5146_CR4","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.drugalcdep.2017.08.003","volume":"180","author":"RK Bachtell","year":"2017","unstructured":"Bachtell RK, Jones JD, Heinzerling KG, Beardsley PM, Comer SD (2017) Glial and neuroinflammatory targets for treating substance use disorders. Drug Alcohol Depend 180:156\u2013170","journal-title":"Drug Alcohol Depend"},{"key":"5146_CR5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.neubiorev.2016.11.008","volume":"73","author":"A Baldacchino","year":"2017","unstructured":"Baldacchino A, Armanyous M, Balfour D, Humphris G, Matthews K (2017) Neuropsychological functioning and chronic methadone use: a systematic review and meta-analysis. Neurosci Biobehav Rev 73:23\u201338","journal-title":"Neurosci Biobehav Rev"},{"key":"5146_CR6","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.jpain.2010.02.019","volume":"11","author":"CR Chapman","year":"2010","unstructured":"Chapman CR, Lipschitz DL, Angst MS, Chou R, Denisco RC, Donaldson GW, Fine PG, Foley KM, Gallagher RM, Gilson AM, Haddox JD, Horn SD, Inturrisi CE, Jick SS, Lipman AG, Loeser JD, Noble M, Porter L, Rowbotham MC, Schoelles KM, Turk DC, Volinn E, von Korff MR, Webster LR, Weisner CM (2010) Opioid pharmacotherapy for chronic non-cancer pain in the United States: a research guideline for developing an evidence-base. J Pain 11:807\u2013829","journal-title":"J Pain"},{"key":"5146_CR7","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jpain.2005.08.001","volume":"7","author":"LF Chu","year":"2006","unstructured":"Chu LF, Clark DJ, Angst MS (2006) Opioid tolerance and hyperalgesia in chronic pain patients after one month of oral morphine therapy: a preliminary prospective study. J Pain 7:43\u201348","journal-title":"J Pain"},{"key":"5146_CR8","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/0885-3924(94)90203-8","volume":"9","author":"MA Compton","year":"1994","unstructured":"Compton MA (1994) Cold-pressor pain tolerance in opiate and cocaine abusers: correlates of drug type and use status. J Pain Symptom Manag 9:462\u2013473","journal-title":"J Pain Symptom Manag"},{"key":"5146_CR9","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.drugalcdep.2010.01.006","volume":"109","author":"P Compton","year":"2010","unstructured":"Compton P, Kehoe P, Sinha K, Torrington MA, Ling W (2010) Gabapentin improves cold-pressor pain responses in methadone-maintained patients. Drug Alcohol Depend 109:213\u2013219","journal-title":"Drug Alcohol Depend"},{"key":"5146_CR10","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.jpain.2012.01.001","volume":"13","author":"P Compton","year":"2012","unstructured":"Compton P, Canamar CP, Hillhouse M, Ling W (2012) Hyperalgesia in heroin dependent patients and the effects of opioid substitution therapy. J Pain 13:401\u2013409","journal-title":"J Pain"},{"key":"5146_CR11","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.bbi.2007.07.014","volume":"22","author":"Y Cui","year":"2008","unstructured":"Cui Y, Liao XX, Liu W, Guo RX, Wu ZZ, Zhao CM, Chen PX, Feng JQ (2008) A novel role of minocycline: attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia. Brain Behav Immun 22:114\u2013123. \n                    https:\/\/doi.org\/10.1016\/j.bbi.2007.07.014","journal-title":"Brain Behav Immun"},{"key":"5146_CR12","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jhsa.2016.12.011","volume":"42","author":"CM Curtin","year":"2017","unstructured":"Curtin CM, Kenney D, Suarez P, Hentz VR, Hernandez-Boussard T, Mackey S, Carroll IR (2017) A double-blind placebo randomized controlled trial of minocycline to reduce pain after carpal tunnel and trigger finger release. J Hand Surg 42:166\u2013174. \n                    https:\/\/doi.org\/10.1016\/j.jhsa.2016.12.011","journal-title":"J Hand Surg"},{"issue":"8","key":"5146_CR13","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/s41583-018-0028-x","volume":"19","author":"E Darcq","year":"2018","unstructured":"Darcq E, Kieffer BL (2018) Opioid receptors: drivers to addiction? Nat Rev Neurosci 19(8):499\u2013514. \n                    https:\/\/doi.org\/10.1038\/s41583-018-0028-x","journal-title":"Nat Rev Neurosci"},{"key":"5146_CR14","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0304-3959(00)00391-2","volume":"90","author":"M Doverty","year":"2001","unstructured":"Doverty M, White JM, Somogyi AA, Bochner F, Ali R, Ling W (2001) Hyperalgesic responses in methadone maintenance patients. Pain 90:91\u201396","journal-title":"Pain"},{"key":"5146_CR15","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1007\/s10865-015-9675-9","volume":"39","author":"EL Garland","year":"2016","unstructured":"Garland EL, Brown SM, Howard MO (2016) Thought suppression as a mediator of the association between depressed mood and prescription opioid craving among chronic pain patients. J Behav Med 39:128\u2013138","journal-title":"J Behav Med"},{"key":"5146_CR16","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3109\/00952998709001515","volume":"13","author":"L Handelsman","year":"1987","unstructured":"Handelsman L, Cochrane KJ, Aronson MJ, Ness R, Rubinstein KJ, Kanof PD (1987) Two new rating scales for opiate withdrawal. Am J Drug Alcohol Abuse 13:293\u2013308","journal-title":"Am J Drug Alcohol Abuse"},{"key":"5146_CR17","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s00213-015-4169-6","volume":"233","author":"Y Hou","year":"2016","unstructured":"Hou Y, Xie G, Liu X, Li G, Jia C, Xu J, Wang B (2016) Minocycline protects against lipopolysaccharide-induced cognitive impairment in mice. Psychopharmacology 233:905\u2013916","journal-title":"Psychopharmacology"},{"key":"5146_CR18","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/j.bbi.2008.07.008","volume":"22","author":"MR Hutchinson","year":"2008","unstructured":"Hutchinson MR, Northcutt AL, Chao LW, Kearney JJ, Zhang Y, Berkelhammer DL, Loram LC, Rozeske RR, Bland ST, Maier SF, Gleeson TT, Watkins LR (2008) Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia. Brain Behav Immun 22:1248\u20131256","journal-title":"Brain Behav Immun"},{"key":"5146_CR19","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.bbi.2009.08.004","volume":"24","author":"MR Hutchinson","year":"2010","unstructured":"Hutchinson MR et al (2010) Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain, Behav Immun 24:83\u201395","journal-title":"Brain, Behav Immun"},{"key":"5146_CR20","first-page":"1","volume":"25","author":"W-J Jin","year":"2014","unstructured":"Jin W-J, Feng S-W, Feng Z, Lu S-M, Qi T, Qian Y-N (2014) Minocycline improves postoperative cognitive impairment in aged mice by inhibiting astrocytic activation. Neuroreport 25:1\u20136","journal-title":"Neuroreport"},{"key":"5146_CR21","doi-asserted-by":"publisher","first-page":"e40461","DOI":"10.1371\/journal.pone.0040461","volume":"7","author":"TA Kato","year":"2012","unstructured":"Kato TA, Watabe M, Tsuboi S, Ishikawa K, Hashiya K, Monji A, Utsumi H, Kanba S (2012) Minocycline modulates human social decision-making: possible impact of microglia on personality-oriented social behaviors. PLoS One 7:e40461","journal-title":"PLoS One"},{"key":"5146_CR22","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1097\/00002508-200409000-00005","volume":"20","author":"S Keller","year":"2004","unstructured":"Keller S, Bann CM, Dodd SL, Schein J, Mendoza TR, Cleeland CS (2004) Validity of the brief pain inventory for use in documenting the outcomes of patients with noncancer pain. Clin J Pain 20:309\u2013318","journal-title":"Clin J Pain"},{"key":"5146_CR23","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.pain.2006.06.028","volume":"126","author":"M Koltzenburg","year":"2006","unstructured":"Koltzenburg M, Pokorny R, Gasser UE, Richarz U (2006) Differential sensitivity of three experimental pain models in detecting the analgesic effects of transdermal fentanyl and buprenorphine. Pain 126:165\u2013174. \n                    https:\/\/doi.org\/10.1016\/j.pain.2006.06.028","journal-title":"Pain"},{"key":"5146_CR24","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.mehy.2012.08.021","volume":"79","author":"Q Li","year":"2012","unstructured":"Li Q (2012) Antagonists of toll like receptor 4 maybe a new strategy to counteract opioid-induced hyperalgesia and opioid tolerance. Med Hypotheses 79:754\u2013756","journal-title":"Med Hypotheses"},{"key":"5146_CR25","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.drugalcdep.2016.02.047","volume":"162","author":"MO Martel","year":"2016","unstructured":"Martel MO, Finan PH, McHugh RK, Issa M, Edwards RR, Jamison RN, Wasan AD (2016) Day-to-day pain symptoms are only weakly associated with opioid craving among patients with chronic pain prescribed opioid therapy. Drug Alcohol Depend 162:130\u2013136","journal-title":"Drug Alcohol Depend"},{"key":"5146_CR26","unstructured":"McNair D, Lorr M, Droppleman L (1992) POMS Manual\u2013Profile of Mood Questionnaire San Diego: Edits"},{"key":"5146_CR27","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/0304-3959(87)91074-8","volume":"30","author":"R Melzack","year":"1987","unstructured":"Melzack R (1987) The short-form McGill pain questionnaire. Pain 30:191\u2013197","journal-title":"Pain"},{"key":"5146_CR28","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.ejphar.2007.01.013","volume":"560","author":"J Mika","year":"2007","unstructured":"Mika J, Osikowicz M, Makuch W, Przewlocka B (2007) Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain. Eur J Pharmacol 560:142\u2013149","journal-title":"Eur J Pharmacol"},{"key":"5146_CR29","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.tins.2007.07.007","volume":"30","author":"JM Pocock","year":"2007","unstructured":"Pocock JM, Kettenmann H (2007) Neurotransmitter receptors on microglia. Trends Neurosci 30:527\u2013535. \n                    https:\/\/doi.org\/10.1016\/j.tins.2007.07.007","journal-title":"Trends Neurosci"},{"key":"5146_CR30","unstructured":"Rezapour T, DeVito EE, Sofuoglu M, Ekhtiari H (2016) Perspectives on neurocognitive rehabilitation as an adjunct treatment for addictive disorders: from cognitive improvement to relapse prevention. In: Progress in brain research, vol 224. Elsevier, pp 345\u2013369"},{"key":"5146_CR31","first-page":"S105","volume":"11","author":"M Ricardo Buenaventura","year":"2008","unstructured":"Ricardo Buenaventura M, Rajive Adlaka M, Nalini Sehgal M (2008) Opioid complications and side effects. Pain Phys 11:S105\u2013S120","journal-title":"Pain Phys"},{"key":"5146_CR32","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S0028-3932(97)00015-8","volume":"35","author":"IH Robertson","year":"1997","unstructured":"Robertson IH, Manly T, Andrade J, Baddeley BT, Yiend J (1997) Oops!': performance correlates of everyday attentional failures in traumatic brain injured and normal subjects. Neuropsychologia 35:747\u2013758","journal-title":"Neuropsychologia"},{"key":"5146_CR33","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.jpain.2017.03.009","volume":"18","author":"MS Samour","year":"2017","unstructured":"Samour MS, Nagi SS, Shortland PJ, Mahns DA (2017) Minocycline prevents muscular pain hypersensitivity and cutaneous allodynia produced by repeated intramuscular injections of hypertonic saline in healthy human participants. J Pain 18:994\u20131005. \n                    https:\/\/doi.org\/10.1016\/j.jpain.2017.03.009","journal-title":"J Pain"},{"key":"5146_CR34","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.tins.2013.12.001","volume":"37","author":"AM Smith","year":"2014","unstructured":"Smith AM, Dragunow M (2014) The human side of microglia. Trends Neurosci 37:125\u2013135","journal-title":"Trends Neurosci"},{"key":"5146_CR35","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.pbb.2008.11.004","volume":"92","author":"M Sofuoglu","year":"2009","unstructured":"Sofuoglu M, Waters AJ, Mooney M, O'malley SS (2009) Minocycline reduced craving for cigarettes but did not affect smoking or intravenous nicotine responses in humans. Pharmacol Biochem Behav 92:135\u2013140","journal-title":"Pharmacol Biochem Behav"},{"key":"5146_CR36","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00213-010-2014-5","volume":"213","author":"M Sofuoglu","year":"2011","unstructured":"Sofuoglu M, Mooney M, Kosten T, Waters A, Hashimoto K (2011) Minocycline attenuates subjective rewarding effects of dextroamphetamine in humans. Psychopharmacology 213:61\u201368","journal-title":"Psychopharmacology"},{"key":"5146_CR37","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.neuropharm.2012.06.021","volume":"64","author":"M Sofuoglu","year":"2013","unstructured":"Sofuoglu M, DeVito EE, Waters AJ, Carroll KM (2013) Cognitive enhancement as a treatment for drug addictions. Neuropharmacology 64:452\u2013463","journal-title":"Neuropharmacology"},{"key":"5146_CR38","doi-asserted-by":"crossref","unstructured":"Stone AA, Shiffman S (1994) Ecological momentary assessment (EMA) in behavorial medicine Annals of Behavioral Medicine","DOI":"10.1093\/abm\/16.3.199"},{"issue":"13","key":"5146_CR39","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1037\/h0070037","volume":"3","author":"EL Thorndike","year":"1919","unstructured":"Thorndike EL (1919) A standardized group examination of intelligence independent of language. J Appl Psychol 3(13):13\u201332","journal-title":"J Appl Psychol"},{"key":"5146_CR40","doi-asserted-by":"publisher","first-page":"13879","DOI":"10.1523\/JNEUROSCI.2711-15.2015","volume":"35","author":"T Trang","year":"2015","unstructured":"Trang T, Al-Hasani R, Salvemini D, Salter MW, Gutstein H, Cahill CM (2015) Pain and poppies: the good, the bad, and the ugly of opioid analgesics. J Neurosci 35:13879\u201313888","journal-title":"J Neurosci"},{"key":"5146_CR41","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1097\/aln.0000000000000508","volume":"122","author":"P Vanelderen","year":"2015","unstructured":"Vanelderen P, van Zundert J, Kozicz T, Puylaert M, de Vooght P, Mestrum R, Heylen R, Roubos E, Vissers K (2015) Effect of minocycline on lumbar radicular neuropathic pain: a randomized, placebo-controlled, double-blind clinical trial with amitriptyline as a comparator. Anesthesiology 122:399\u2013406. \n                    https:\/\/doi.org\/10.1097\/aln.0000000000000508","journal-title":"Anesthesiology"},{"key":"5146_CR42","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1186\/s12974-017-0998-z","volume":"14","author":"M Wadhwa","year":"2017","unstructured":"Wadhwa M, Prabhakar A, Ray K, Roy K, Kumari P, Jha PK, Kishore K, Kumar S, Panjwani U (2017) Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep deprivation. J Neuroinflammation 14:222","journal-title":"J Neuroinflammation"},{"key":"5146_CR43","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00213-011-2509-8","volume":"220","author":"M Watabe","year":"2012","unstructured":"Watabe M, Kato TA, Monji A, Horikawa H, Kanba S (2012) Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction? Psychopharmacology 220:551\u2013557","journal-title":"Psychopharmacology"},{"key":"5146_CR44","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.tips.2009.08.002","volume":"30","author":"LR Watkins","year":"2009","unstructured":"Watkins LR, Hutchinson MR, Rice KC, Maier SF (2009) The \"toll\" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends Pharmacol Sci 30:581\u2013591. \n                    https:\/\/doi.org\/10.1016\/j.tips.2009.08.002","journal-title":"Trends Pharmacol Sci"},{"key":"5146_CR45","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/1440-1681.12316","volume":"42","author":"X Zhang","year":"2015","unstructured":"Zhang X, Wang J, Yu T, Du D, Jiang W (2015) Minocycline can delay the development of morphine tolerance, but cannot reverse existing tolerance in the maintenance period of neuropathic pain in rats. Clin Exp Pharmacol Physiol 42:94\u2013101","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"5146_CR46","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.pnpbp.2018.04.004","volume":"85","author":"L Zhang","year":"2018","unstructured":"Zhang L, Zheng H, Wu R, Zhu F, Kosten TR, Zhang XY, Zhao J (2018) Minocycline adjunctive treatment to risperidone for negative symptoms in schizophrenia: association with pro-inflammatory cytokine levels. Prog Neuro-Psychopharmacol Biol Psychiatry 85:69\u201376. \n                    https:\/\/doi.org\/10.1016\/j.pnpbp.2018.04.004","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-018-5146-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-018-5146-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-018-5146-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T09:20:12Z","timestamp":1589620812000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-018-5146-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,18]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["5146"],"URL":"https:\/\/doi.org\/10.1007\/s00213-018-5146-7","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,18]]},"assertion":[{"value":"31 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}