{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:00:35Z","timestamp":1791612035432,"version":"4.3.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004045","name":"Karadeniz Teknik \u00dcniversitesi","doi-asserted-by":"publisher","award":["TTU-2016-5451"],"award-info":[{"award-number":["TTU-2016-5451"]}],"id":[{"id":"10.13039\/501100004045","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1007\/s00213-018-5154-7","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T19:55:28Z","timestamp":1546545328000},"page":"1717-1728","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Anti-inflammatory and antinociceptive activities of glucagon-like peptides: evaluation of their actions on serotonergic, nitrergic, and opioidergic systems"],"prefix":"10.1007","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8224-4006","authenticated-orcid":false,"given":"Duygun Alt\u0131nta\u015f","family":"Aykan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Kesim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beyza","family":"Ayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015feg\u00fcl","family":"Kurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"issue":"2\u20133","key":"5154_CR1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0378-8741(02)00295-7","volume":"84","author":"B Adzu","year":"2003","unstructured":"Adzu B, Amos S, Kapu SD, Gamaniel KS (2003) Anti-inflammatory and antinociceptive effects of Sphaeranthus senegalensis. J Ethnopharmacol 84(2\u20133):169\u2013173","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"5154_CR2","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1210\/en.2014-1829","volume":"156","author":"K Austin","year":"2015","unstructured":"Austin K, Imam NA, Pintar JE, Brubaker PL (2015) IGF binding protein-4 is required for the growth effects of glucagon-like peptide-2 in murine intestine. Endocrinology 156(2):429\u2013436","journal-title":"Endocrinology"},{"key":"5154_CR3","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.brainres.2015.06.043","volume":"1622","author":"SH Avila-Rojas","year":"2015","unstructured":"Avila-Rojas SH, Vel\u00e1zquez-Lagunas I, Salinas-Abarca AB, Barrag\u00e1n-Iglesias P, Pineda-Farias JB, Granados-Soto V (2015) Role of spinal 5-HT5A, and 5-HT1A\/1B\/1D, receptors in neuropathic pain induced by spinal nerve ligation in rats. Brain Res 1622:377\u2013385","journal-title":"Brain Res"},{"issue":"6","key":"5154_CR4","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1053\/j.gastro.2007.03.054","volume":"132","author":"LL Baggio","year":"2007","unstructured":"Baggio LL, Drucker DJ (2007) Biology of incretins: GLP -1 and GIP. Gastroenterology 132(6):2131\u20132157","journal-title":"Gastroenterology"},{"key":"5154_CR5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.neuroscience.2011.12.041","volume":"211","author":"M Barrot","year":"2012","unstructured":"Barrot M (2012) Tests and models of nociception and pain in rodents. Neuroscience 211:39\u201350. \n                    https:\/\/doi.org\/10.1016\/j.neuroscience.2011.12.041","journal-title":"Neuroscience"},{"issue":"1","key":"5154_CR6","first-page":"190","volume":"222","author":"LS Brady","year":"1982","unstructured":"Brady LS, Holtzman SG (1982) Analgesic effects of intraventricular morphine and enkephalins in nondependent and morphine-dependent rats. J Pharmacol Exp Ther 222(1):190\u2013197","journal-title":"J Pharmacol Exp Ther"},{"issue":"1\u20133","key":"5154_CR7","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.regpep.2004.04.014","volume":"121","author":"K Bulut","year":"2004","unstructured":"Bulut K, Meier JJ, Ansorge N, Felderbauer P, Schmitz F, Hoffmann P, Schmidt WE, Gallwitz B (2004) Glucagon-like peptide 2 improves intestinal wound healing through induction of epithelial cell migration in vitro-evidence for a TGF--beta-mediated effect. Regul Pept 121(1\u20133):137\u2013143","journal-title":"Regul Pept"},{"issue":"2\u20133","key":"5154_CR8","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ejphar.2007.08.044","volume":"578","author":"K Bulut","year":"2008","unstructured":"Bulut K, Pennartz C, Felderbauer P, Meier JJ, Banasch M, Bulut D, Schmitz F, Schmidt WE, Hoffmann P (2008) Glucagon like peptide-2 induces intestinal restitution through VEGF release from subepithelial myofibroblasts. Eur J Pharmacol 578(2\u20133):279\u2013285","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"5154_CR9","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/bph.12895","volume":"172","author":"H Fan","year":"2015","unstructured":"Fan H, Gong N, Li TF, Ma AN, Wu XY, Wang MW, Wang YX (2015) The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating \u03b2-endorphin release from spinal microglia. Br J Pharmacol 172(1):64\u201379","journal-title":"Br J Pharmacol"},{"issue":"15","key":"5154_CR10","doi-asserted-by":"publisher","first-page":"5322","DOI":"10.1523\/JNEUROSCI.4703-13.2014","volume":"34","author":"N Gong","year":"2014","unstructured":"Gong N, Xiao Q, Zhu B, Zhang CY, Wang YC, Fan H, Ma AN, Wang YX (2014) Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity. J Neurosci 34(15):5322\u20135334. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.4703-13.2014","journal-title":"J Neurosci"},{"issue":"3","key":"5154_CR11","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.jep.2009.05.012","volume":"124","author":"V Hajhashemi","year":"2009","unstructured":"Hajhashemi V, Sajjadi SE, Heshmati M (2009) Anti-inflammatory and analgesic properties of Heracleum persicum essential oil and hydroalcoholic extract in animal models. J Ethnopharmacol 124(3):475\u2013480","journal-title":"J Ethnopharmacol"},{"key":"5154_CR12","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ejphar.2017.07.015","volume":"812","author":"DBR Insuela","year":"2017","unstructured":"Insuela DBR, Carvalho VF (2017) Glucagon and glucagon-like peptide-1 as novel anti-inflammatory and immunomodulatory compounds. Eur J Pharmacol 812:64\u201372. \n                    https:\/\/doi.org\/10.1016\/j.ejphar.2017.07.015","journal-title":"Eur J Pharmacol"},{"key":"5154_CR13","doi-asserted-by":"publisher","unstructured":"Ismail NI, Ming-Tatt L, Lajis N, Akhtar MN, Akira A, Perimal EK, Israf DA, Sulaiman MR (2016) Antinociceptive effect of 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in mice models of induced nociception. Molecules 21(8). doi: \n                    https:\/\/doi.org\/10.3390\/molecules21081077","DOI":"10.3390\/molecules21081077"},{"issue":"1","key":"5154_CR14","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.bbr.2009.06.020","volume":"204","author":"T Iwai","year":"2009","unstructured":"Iwai T, Hayashi Y, Narita S, Kasuya Y, Jin K, Tsugane M, Oka J (2009) Antidepressant-like effects of glucagon-like peptide-2 in mice occur via monoamine pathways. Behav Brain Res 204(1):235\u2013240","journal-title":"Behav Brain Res"},{"issue":"1","key":"5154_CR15","doi-asserted-by":"publisher","first-page":"26","DOI":"10.4103\/2229-516X.198516","volume":"7","author":"UA Kagal","year":"2017","unstructured":"Kagal UA, Angadi NB, Matule SM (2017) Effect of dipeptidyl peptidase 4 inhibitors on acute and subacute models of inflammation in male Wistar rats: an experimental study. Int J Appl Basic Med Res 7(1):26\u201331","journal-title":"Int J Appl Basic Med Res"},{"issue":"2","key":"5154_CR16","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1111\/j.1476-5381.1994.tb13108.x","volume":"112","author":"A Kawabata","year":"1994","unstructured":"Kawabata A, Manabe S, Manabe Y, Takagi H (1994) Effect of topical injection of L-arginine on formalin-induced nosiception in the mouse: a dual role of peripherally formed NO in pain modulation. Br J Pharmacol 112(2):547\u2013550","journal-title":"Br J Pharmacol"},{"key":"5154_CR17","doi-asserted-by":"publisher","first-page":"11412","DOI":"10.1523\/JNEUROSCI.3600-07.2007","volume":"27","author":"LJ Macpherson","year":"2007","unstructured":"Macpherson LJ, Xiao B, Kwan KY, Petrus MJ, Dubin AE, Hwang S, Cravatt B, Corey DP, Patapoutian A (2007) An ion channel essential for sensing chemical damage. J Neurosci 27:11412\u201311415","journal-title":"J Neurosci"},{"issue":"1\u20133","key":"5154_CR18","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.pain.2006.06.014","volume":"126","author":"A Miranda","year":"2006","unstructured":"Miranda A, Peles S, McLean PG, Sengupta JN (2006) Effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia. Pain 126(1\u20133):54\u201363","journal-title":"Pain"},{"key":"5154_CR19","doi-asserted-by":"publisher","unstructured":"Nerup N, Ambrus R, Lindhe J, Achiam MP, Jeppesen PB, Svendsen LB (2017) The effect of glucagon-like peptide-1 and glucagon-like peptide-2 on microcirculation: a systematic review. Microcirculation. \n                    https:\/\/doi.org\/10.1111\/micc.12367","DOI":"10.1111\/micc.12367"},{"key":"5154_CR20","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.bbr.2017.01.004","volume":"321","author":"C Palleria","year":"2017","unstructured":"Palleria C, Leo A, Andreozzi F, Citraro R, Iannone M, Spiga R, Sesti G, Constanti A, De Sarro G, Arturi F, Russo E (2017) Liraglutide prevents cognitive decline in a rat model of streptozotocin-induced diabetes independently from its peripheral metabolic effects. Behav Brain Res 321:157\u2013169. \n                    https:\/\/doi.org\/10.1016\/j.bbr.2017.01.004","journal-title":"Behav Brain Res"},{"issue":"5","key":"5154_CR21","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1021\/acschemneuro.6b00414","volume":"8","author":"MS Shajib","year":"2017","unstructured":"Shajib MS, Baranov A, Khan WI (2017) Diverse effects of gut-derived serotonin in intestinal inflammation. ACS Chem Neurosci 8(5):920\u2013931","journal-title":"ACS Chem Neurosci"},{"issue":"3","key":"5154_CR22","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/0304-3959(89)90222-4","volume":"38","author":"M Shibata","year":"1989","unstructured":"Shibata M, Ohkubo T, Takahashi H, Inoki R (1989) Modified formalin test: characteristic biphasic pain response. Pain 38(3):347\u2013352","journal-title":"Pain"},{"issue":"1","key":"5154_CR23","doi-asserted-by":"publisher","first-page":"G211","DOI":"10.1152\/ajpgi.00530.2006","volume":"293","author":"DL Sigalet","year":"2007","unstructured":"Sigalet DL, Wallace LE, Holst JJ, Martin GR, Kaji T, Tanaka H, Sharkey KA (2007) Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2. Am J Physiol Gastrointest Liver Physiol 293(1):G211\u2013G221","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"2","key":"5154_CR24","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s11916-006-0020-4","volume":"10","author":"C Sommer","year":"2006","unstructured":"Sommer C (2006) Is serotonin hyperalgesic or analgesic? Curr Pain Headache Rep 10(2):101\u2013106 Review","journal-title":"Curr Pain Headache Rep"},{"issue":"1","key":"5154_CR25","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/0304-3959(92)90003-T","volume":"51","author":"A Tj\u00f8lsen","year":"1992","unstructured":"Tj\u00f8lsen A, Berge OG, Hunskaar S, Rosland JH, Hole K (1992) The formalin test: an evaluation of the method. Pain 51(1):5\u201317","journal-title":"Pain"},{"key":"5154_CR26","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/bs.pmbts.2015.07.010","volume":"135","author":"E Trefts","year":"2015","unstructured":"Trefts E, Williams AS, Wasserman DH (2015) Exercise and the regulation of hepatic metabolism. Prog Mol Biol Transl Sci 135:203\u2013225. \n                    https:\/\/doi.org\/10.1016\/bs.pmbts.2015.07.010\n                    \n                   Review","journal-title":"Prog Mol Biol Transl Sci"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-018-5154-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-018-5154-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-018-5154-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T19:04:54Z","timestamp":1578078294000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-018-5154-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,4]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["5154"],"URL":"https:\/\/doi.org\/10.1007\/s00213-018-5154-7","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,4]]},"assertion":[{"value":"28 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was carried out at Karadeniz Technical University Medical Faculty, Medical Pharmacology Department. Local ethics committee approved the study (Ethics Committee File No: 2015\/44, Approval date: 15\/12\/2015).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}