{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:42:38Z","timestamp":1773679358468,"version":"3.50.1"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T00:00:00Z","timestamp":1552608000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T00:00:00Z","timestamp":1552608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R21-DA039301"],"award-info":[{"award-number":["R21-DA039301"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["K01-DA035974"],"award-info":[{"award-number":["K01-DA035974"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s00213-019-05211-5","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T18:17:22Z","timestamp":1552673842000},"page":"2143-2153","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of chronic cocaine self-administration and N-acetylcysteine on learning, cognitive flexibility, and reinstatement in nonhuman primates"],"prefix":"10.1007","volume":"236","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4597-9801","authenticated-orcid":false,"given":"Brian D.","family":"Kangas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel J.","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Kohut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc J.","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,3,15]]},"reference":[{"key":"5211_CR1","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0376-8716(03)00092-9","volume":"71","author":"E Aharonovich","year":"2003","unstructured":"Aharonovich E, Nunes E, Hasin D (2003) Cognitive impairment, retention and abstinence among cocaine abusers in cognitive-behavioral treatment. Drug Alcohol Depend 71:207\u2013211","journal-title":"Drug Alcohol Depend"},{"key":"5211_CR2","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.drugalcdep.2005.08.003","volume":"81","author":"E Aharonovich","year":"2006","unstructured":"Aharonovich E, Hasin DS, Brooks AC, Liu X, Bisaga A, Nunes EV (2006) Cognitive deficits predict low treatment retention in cocaine dependent patients. Drug Alcohol Depend 81:313\u2013322","journal-title":"Drug Alcohol Depend"},{"key":"5211_CR3","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/npp.2010.226","volume":"36","author":"SL Amen","year":"2011","unstructured":"Amen SL, Piacentine LB, Ahmad ME, Li SJ, Mantsch JR, Risinger RC, Baker DA (2011) Repeated N-acetyl cysteine reduces cocaine seeking in rodents and craving in cocaine-dependent humans. Neuropsychopharmacology 36:871\u2013878","journal-title":"Neuropsychopharmacology"},{"key":"5211_CR4","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/nn1069","volume":"6","author":"DA Baker","year":"2003","unstructured":"Baker DA, McFarland K, Lake RW, Shen H, Tang XC, Toda S, Kalivas PW (2003) Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci 6:743\u2013749","journal-title":"Nat Neurosci"},{"key":"5211_CR5","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.pbb.2011.12.018","volume":"101","author":"RM Bauzo","year":"2012","unstructured":"Bauzo RM, Kimmel HL, Howell LL (2012) The cystine-glutamate transporter enhancer N-acetyl-L-cysteine attenuates cocaine-induced changes in striatal dopamine but not self-administration in squirrel monkeys. Pharmacol Biochem Behav 101:288\u2013296","journal-title":"Pharmacol Biochem Behav"},{"key":"5211_CR6","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1111\/j.1369-1600.2011.00428.x","volume":"17","author":"OM Ben-Shahar","year":"2012","unstructured":"Ben-Shahar OM, Szumlinski KK, Lominac KD, Cohen A, Gordon E, Ploense KL, DeMartini J, Bernstein N, Rudy NM, Nabhan AN, Sacramento A, Pagano K, Carosso GA, Woodward N (2012) Extended access to cocaine self-administration results in reduced glutamate function within the medial prefrontal cortex. Addict Biol 17:746\u2013757","journal-title":"Addict Biol"},{"key":"5211_CR7","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.tips.2013.01.001","volume":"34","author":"M Berk","year":"2013","unstructured":"Berk M, Malhi GS, Gray LJ, Dean OM (2013) The promise of N-acetylcysteine in neuropsychiatry. Trends Pharmacol Sci 34:167\u2013177","journal-title":"Trends Pharmacol Sci"},{"key":"5211_CR8","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.neuropharm.2018.03.021","volume":"135","author":"S Charntikov","year":"2018","unstructured":"Charntikov S, Pittenger ST, Pudiak CM, Bevins RA (2018) The effect of N-acetylcysteine or bupropion on methamphetamine self-administration and methamphetamine-triggered reinstatement of female rats. Neuropharmacology 135:487\u2013495","journal-title":"Neuropharmacology"},{"key":"5211_CR9","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1037\/a0023766","volume":"125","author":"Y Chudasama","year":"2011","unstructured":"Chudasama Y (2011) Animal models of prefrontal-executive function. Behav Neurosci 125:327\u2013343","journal-title":"Behav Neurosci"},{"key":"5211_CR10","doi-asserted-by":"publisher","first-page":"59","DOI":"10.4324\/9780203311875_chapter_3","volume-title":"The cognitive neuroscience of social behavior","author":"A Easton","year":"2005","unstructured":"Easton A (2005) Behavioural flexibility, social learning, and the frontal cortex. In: Easton A, Emery NJ (eds) The cognitive neuroscience of social behavior. Psychology Press, New York, pp 59\u201380"},{"key":"5211_CR11","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.bbr.2014.02.044","volume":"266","author":"M Frankowska","year":"2014","unstructured":"Frankowska M, Jastrz\u0119bska J, Nowak E, Bia\u0142ko M, Przegali\u0144ski E, Filip M (2014) The effects of N-acetylcysteine on cocaine reward and seeking behaviors in a rat model of depression. Behav Brain Res 266:108\u2013118","journal-title":"Behav Brain Res"},{"key":"5211_CR12","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.biopsych.2012.05.001","volume":"72","author":"RW Gould","year":"2012","unstructured":"Gould RW, Gage HD, Nader MA (2012) Effects of chronic cocaine self-administration on cognition and cerebral glucose utilization in rhesus monkeys. Biol Psychiatry 72:856\u2013863","journal-title":"Biol Psychiatry"},{"key":"5211_CR13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0149-2918(00)88479-9","volume":"22","author":"EM Grandjean","year":"2000","unstructured":"Grandjean EM, Berthet P, Ruffmann R, Leuenberger P (2000) Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebocontrolled clinical trials. Clin Ther 22:209\u2013221","journal-title":"Clin Ther"},{"key":"5211_CR14","doi-asserted-by":"publisher","first-page":"5843","DOI":"10.1523\/JNEUROSCI.0029-12.2012","volume":"32","author":"SM Groman","year":"2012","unstructured":"Groman SM, Lee B, Seu E, James AS, Feiler K, Mandelkern MA, London ED, Jentsch JD (2012) Dysregulation of D2-mediated dopamine transmission in monkeys after chronic escalating methamphetamine exposure. J Neurosci 32:5843\u20135852","journal-title":"J Neurosci"},{"key":"5211_CR15","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s00213-013-3159-9","volume":"229","author":"SM Groman","year":"2013","unstructured":"Groman SM, Morales AM, Lee B, London ED, Jentsch JD (2013) Methamphetamine-induced increases in putamen gray matter associate with inhibitory control. Psychopharmacology 229:527\u2013538","journal-title":"Psychopharmacology"},{"key":"5211_CR16","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1080\/00498254.2016.1187777","volume":"47","author":"FT Hagos","year":"2017","unstructured":"Hagos FT, Daood MJ, Ocque JA, Nolin TD, Bayir H, Poloyac SM, Kochanek PM, Clark RS, Empey PE (2017) Probenecid, an organic anion transporter 1 and 3 inhibitor, increases plasma and brain exposure of N-acetylcysteine. Xenobiotica 47:346\u2013353","journal-title":"Xenobiotica"},{"key":"5211_CR17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.neulet.2017.08.013","volume":"657","author":"AY Hakami","year":"2017","unstructured":"Hakami AY, Sari Y (2017) \u03b2-Lactamase inhibitor, clavulanic acid, attenuates ethanol intake and increases glial glutamate transporters expression in alcohol preferring rats. Neurosci Lett 657:140\u2013145","journal-title":"Neurosci Lett"},{"issue":"18","key":"5211_CR18","first-page":"30743","volume":"S0166-4328","author":"AY Hakami","year":"2018","unstructured":"Hakami AY, Alshehri FS, Sari Y (2018) \u03b2-lactams modulate astroglial glutamate transporters and attenuate dependence to CP 55,940, a CB1 receptor agonist, in rat model. Behav Brain Res S0166-4328(18):30743\u201330745","journal-title":"Behav Brain Res"},{"key":"5211_CR19","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1152\/ajplegacy.1969.217.1.24","volume":"217","author":"JA Herd","year":"1969","unstructured":"Herd JA, Morse WH, Kelleher RT, Jones LG (1969) Arterial hypertension in the squirrel monkey during behavioral experiments. Am J Phys 217:24\u201329","journal-title":"Am J Phys"},{"key":"5211_CR20","doi-asserted-by":"publisher","unstructured":"Hodebourg R, Murray JE, Fouyssac M, Puaud M, Everitt BJ, Belin D (2018) Heroin seeking becomes dependent on dorsal striatal dopaminergic mechanisms and can be decreased by N-acetylcysteine. Eur J Neurosci. https:\/\/doi.org\/10.1111\/ejn.13894","DOI":"10.1111\/ejn.13894"},{"key":"5211_CR21","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s00213-011-2579-7","volume":"219","author":"A Izquierdo","year":"2012","unstructured":"Izquierdo A, Jentsch JD (2012) Reversal learning as a measure of impulsive and compulsive behavior in addictions. Psychopharmacology 219:607\u2013620","journal-title":"Psychopharmacology"},{"key":"5211_CR22","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.1007\/s00213-016-4388-5","volume":"233","author":"J Jastrz\u0119bska","year":"2016","unstructured":"Jastrz\u0119bska J, Frankowska M, Filip M, Atlas D (2016) N-acetylcysteine amide (AD4) reduces cocaine-induced reinstatement. Psychopharmacology 233:3437\u20133448","journal-title":"Psychopharmacology"},{"key":"5211_CR23","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0893-133X(01)00355-4","volume":"26","author":"JD Jentsch","year":"2002","unstructured":"Jentsch JD, Olausson P, De La Garza R 2nd, Taylor JR (2002) Impairments of reversal learning and response perseveration after repeated, intermittent cocaine administrations to monkeys. Neuropsychopharmacology 26:183\u2013190","journal-title":"Neuropsychopharmacology"},{"key":"5211_CR24","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1001\/jamapsychiatry.2013.2295","volume":"70","author":"BA Johnson","year":"2013","unstructured":"Johnson BA, Ait-Daoud N, Wang XQ, Penberthy JK, Javors MA, Seneviratne C, Liu L (2013) Topiramate for the treatment of cocaine addiction: a randomized clinical trial. JAMA Psychiatry 70:1338\u20131346","journal-title":"JAMA Psychiatry"},{"key":"5211_CR25","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1038\/mp.2011.46","volume":"16","author":"PW Kalivas","year":"2011","unstructured":"Kalivas PW, Volkow ND (2011) New medications for drug addiction hiding in glutamatergic neuroplasticity. Mol Psychiatry 16:974\u2013986","journal-title":"Mol Psychiatry"},{"key":"5211_CR26","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.jneumeth.2012.06.028","volume":"209","author":"BD Kangas","year":"2012","unstructured":"Kangas BD, Bergman J (2012) A novel touch-sensitive apparatus for behavioral studies in unrestrained squirrel monkeys. J Neurosci Methods 209:331\u2013336","journal-title":"J Neurosci Methods"},{"key":"5211_CR27","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s10071-013-0654-7","volume":"17","author":"BD Kangas","year":"2014","unstructured":"Kangas BD, Bergman J (2014) Repeated acquisition and discrimination reversal in the squirrel monkey (Saimiri sciureus). Anim Cogn 17:221\u2013228","journal-title":"Anim Cogn"},{"key":"5211_CR28","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/s00213-015-4107-7","volume":"233","author":"BD Kangas","year":"2016","unstructured":"Kangas BD, Bergman J (2016) Effects of self-administered methamphetamine on discrimination learning and reversal in nonhuman primates. Psychopharmacology 233:373\u2013380","journal-title":"Psychopharmacology"},{"key":"5211_CR29","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1097\/FBP.0000000000000356","volume":"28","author":"BD Kangas","year":"2017","unstructured":"Kangas BD, Bergman J (2017) Touchscreen technology in the study of cognition-related behavior. Behav Pharmacol 28:623\u2013629","journal-title":"Behav Pharmacol"},{"key":"5211_CR30","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1124\/jpet.115.228189","volume":"357","author":"BD Kangas","year":"2016","unstructured":"Kangas BD, Leonard MZ, Shukla VG, Alapafuja SO, Nikas SP, Makriyannis A, Bergman J (2016) Comparisons of \u03949-tetrahydrocannabinol and anandamide on a battery of cognition-related behavior in nonhuman primates. J Pharmacol Exp Ther 357:125\u2013133","journal-title":"J Pharmacol Exp Ther"},{"key":"5211_CR31","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.neuroscience.2008.06.010","volume":"155","author":"KS Kau","year":"2008","unstructured":"Kau KS, Madayag A, Mantsch JR, Grier MD, Abdulhameed O, Baker DA (2008) Blunted cysteine-glutamate antiporter function in the nucleus accumbens promotes cocaine induced drug seeking. Neuroscience 155:530\u2013537","journal-title":"Neuroscience"},{"key":"5211_CR32","first-page":"1","volume":"60","author":"RT Kelleher","year":"1968","unstructured":"Kelleher RT, Morse WH (1968) Determinants of the specificity of behavioral effects of drugs. Ergeb Physiol Biol Chem Exp Pharmakol 60:1\u201356","journal-title":"Ergeb Physiol Biol Chem Exp Pharmakol"},{"key":"5211_CR33","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s00726-015-2117-8","volume":"48","author":"J Kim","year":"2016","unstructured":"Kim J, John J, Langford D, Walker E, Ward S, Rawls SM (2016) Clavulanic acid enhances glutamate transporter subtype I (GLT-1) expression and decreases reinforcing efficacy of cocaine in mice. Amino Acids 48:689\u2013696","journal-title":"Amino Acids"},{"key":"5211_CR34","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.biopsych.2009.07.018","volume":"67","author":"LA Knackstedt","year":"2010","unstructured":"Knackstedt LA, Melendez RI, Kalivas PW (2010) Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking. Biol Psychiatry 67:81\u201384","journal-title":"Biol Psychiatry"},{"key":"5211_CR35","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/adb.12061","volume":"19","author":"LA Knackstedt","year":"2014","unstructured":"Knackstedt LA, Trantham-Davidson HL, Schwendt M (2014) The role of ventral and dorsal striatum mGluR5 in relapse to cocaine-seeking and extinction learning. Addict Biol 19:87\u2013101","journal-title":"Addict Biol"},{"key":"5211_CR36","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/0166-2236(91)90141-G","volume":"14","author":"MJ Kuhar","year":"1991","unstructured":"Kuhar MJ, Ritz MC, Boja JW (1991) The dopamine hypothesis of the reinforcing properties of cocaine. Trends Neurosci 14:299\u2013302","journal-title":"Trends Neurosci"},{"key":"5211_CR37","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1016\/j.biopsych.2011.10.024","volume":"71","author":"YM Kupchik","year":"2012","unstructured":"Kupchik YM, Moussawi K, Tang XC, Wang X, Kalivas BC, Kolokithas R, Ogburn KB, Kalivas PW (2012) The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine. Biol Psychiatry 71:978\u2013986","journal-title":"Biol Psychiatry"},{"key":"5211_CR38","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1176\/ajp.2007.164.7.1115","volume":"164","author":"SD LaRowe","year":"2007","unstructured":"LaRowe SD, Myrick H, Hedden S, Mardikian P, Saladin M, McRae A, Brady K, Kalivas PW, Malcolm R (2007) Is cocaine desire reduced by N-acetylcysteine? Am J Psychiatry 164:1115\u20131117","journal-title":"Am J Psychiatry"},{"key":"5211_CR39","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1521-0391.2013.12034.x","volume":"22","author":"SD LaRowe","year":"2013","unstructured":"LaRowe SD, Kalivas PW, Nicholas JS, Randall PK, Mardikian PN, Malcolm RJ (2013) A double-blind placebo-controlled trial of N-acetylcysteine in the treatment of cocaine dependence. Am J Addict 22:443\u2013452","journal-title":"Am J Addict"},{"key":"5211_CR40","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.drugalcdep.2017.05.039","volume":"178","author":"B Levi Bolin","year":"2017","unstructured":"Levi Bolin B, Alcorn JL 3rd, Lile JA, Rush CR, Rayapati AO, Hays LR, Stoops WW (2017) N-acetylcysteine reduces cocaine-cue attentional bias and differentially alters cocaine self-administration based on dosing order. Drug Alcohol Depend 178:452\u2013460","journal-title":"Drug Alcohol Depend"},{"key":"5211_CR41","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1093\/cercor\/bhm236","volume":"18","author":"S Liu","year":"2008","unstructured":"Liu S, Heitz RP, Sampson AR, Zhang W, Bradberry CW (2008) Evidence of temporal cortical dysfunction in rhesus monkeys following chronic cocaine self-administration. Cereb Cortex 18:2109\u20132116","journal-title":"Cereb Cortex"},{"key":"5211_CR42","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/s00213-011-2292-6","volume":"217","author":"X Liu","year":"2011","unstructured":"Liu X, Jensen JE, Gillis TE, Zuo CS, Prescot AP, Brimson M, Cayetano K, Renshaw PF, Kaufman MJ (2011) Chronic cocaine exposure induces putamen glutamate and glutamine metabolite abnormalities in squirrel monkeys. Psychopharmacology 217:367\u2013375","journal-title":"Psychopharmacology"},{"key":"5211_CR43","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1037\/h0082753","volume":"22","author":"NJ Mackintosh","year":"1968","unstructured":"Mackintosh NJ, McGonigle B, Holgate V, Vanderver V (1968) Factors underlying improvement in serial reversal learning. Can J Psychol 22:85\u201395","journal-title":"Can J Psychol"},{"key":"5211_CR44","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.pnpbp.2006.10.001","volume":"31","author":"PN Mardikian","year":"2007","unstructured":"Mardikian PN, LaRowe SD, Hedden S, Kalivas PW, Malcolm RJ (2007) An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: a pilot study. Prog Neuro-Psychopharmacol Biol Psychiatry 31:389\u2013394","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"5211_CR45","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.biopsych.2013.06.026","volume":"75","author":"D Martinez","year":"2014","unstructured":"Martinez D, Slifstein M, Nabulsi N, Grassetti A, Urban NB, Perez A, Liu F, Lin SF, Ropchan J, Mao X, Kegeles LS, Shungu DC, Carson RE, Huang Y (2014) Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [11C]ABP688 and magnetic resonance spectroscopy. Biol Psychiatry 75:165\u2013171","journal-title":"Biol Psychiatry"},{"key":"5211_CR46","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s40263-014-0142-x","volume":"28","author":"EA McClure","year":"2014","unstructured":"McClure EA, Gipson CD, Malcolm RJ, Kalivas PW, Gray KM (2014) Potential role of N-acetylcysteine in the management of substance use disorders. CNS Drugs 28:95\u2013106","journal-title":"CNS Drugs"},{"key":"5211_CR47","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0740-5472(01)00202-1","volume":"21","author":"FG Moeller","year":"2001","unstructured":"Moeller FG, Dougherty DM, Barratt ES, Schmitz JM, Swann AC, Grabowski J (2001) The impact of impulsivity on cocaine use and retention in treatment. J Subst Abus Treat 21:193\u2013198","journal-title":"J Subst Abus Treat"},{"key":"5211_CR48","doi-asserted-by":"publisher","first-page":"6389","DOI":"10.1523\/JNEUROSCI.1007-05.2005","volume":"25","author":"MM Moran","year":"2005","unstructured":"Moran MM, McFarland K, Melendez RI, Kalivas PW, Seamans JK (2005) Cystine\/glutamate exchange regulatesmetabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. J Neurosci 25:6389\u20136393","journal-title":"J Neurosci"},{"key":"5211_CR49","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1073\/pnas.1011265108","volume":"108","author":"K Moussawi","year":"2011","unstructured":"Moussawi K, Zhou W, Shen H, Reichel CM, See RE, Carr DB, Kalivas PW (2011) Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse. Proc Natl Acad Sci U S A 108:385\u2013390","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5211_CR50","unstructured":"National Institute on Drug Abuse (NIDA); National Institutes of Health; U.S. Department of Health and Human Services. Cocaine: Drug Facts, July 2018. www.drugabuse.gov\/publications\/drugfacts\/cocaine ; accessed 18 Nov 2018"},{"key":"5211_CR51","volume-title":"Guide for the care and use of laboratory animals: eighth edition","author":"National Research Council","year":"2011","unstructured":"National Research Council (2011) Guide for the care and use of laboratory animals: eighth edition. National Academy Press, Washington DC"},{"key":"5211_CR52","doi-asserted-by":"publisher","first-page":"4926","DOI":"10.1523\/JNEUROSCI.5426-10.2011","volume":"31","author":"JN Porter","year":"2011","unstructured":"Porter JN, Olsen AS, Gurnsey K, Dugan BP, Jedema HP, Bradberry CW (2011) Chronic cocaine self-administration in rhesus monkeys: impact on associative learning, cognitive control, and working memory. J Neurosci 31:4926\u20134934","journal-title":"J Neurosci"},{"key":"5211_CR53","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00213-012-2903-x","volume":"226","author":"JN Porter","year":"2013","unstructured":"Porter JN, Gurnsey K, Jedema HP, Bradberry CW (2013) Latent vulnerability in cognitive performance following chronic cocaine self-administration in rhesus monkeys. Psychopharmacology 226:139\u2013146","journal-title":"Psychopharmacology"},{"key":"5211_CR54","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1097\/ADM.0000000000000066","volume":"8","author":"S Potvin","year":"2014","unstructured":"Potvin S, Stavro K, Rizkallah E, Pelletier J (2014) Cocaine and cognition: a systematic quantitative review. J Addict Med 8:368\u2013376","journal-title":"J Addict Med"},{"key":"5211_CR55","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1111\/acer.13842","volume":"42","author":"ME Quintanilla","year":"2018","unstructured":"Quintanilla ME, Morales P, Ezquer F, Ezquer M, Herrera-Marschitz M, Israel Y (2018) Commonality of ethanol and nicotine reinforcement and relapse in Wistar-derived UChB rats: inhibition by N-acetylcysteine. Alcohol Clin Exp Res 42:1988\u20131999","journal-title":"Alcohol Clin Exp Res"},{"key":"5211_CR56","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00213-012-2837-3","volume":"225","author":"AM Ramirez-Ni\u00f1o","year":"2013","unstructured":"Ramirez-Ni\u00f1o AM, D'Souza MS, Markou A (2013) N-acetylcysteine decreased nicotine self-administration and cue-induced reinstatement of nicotine seeking in rats: comparison with the effects of N-acetylcysteine on food responding and food seeking. Psychopharmacology 225:473\u2013482","journal-title":"Psychopharmacology"},{"key":"5211_CR57","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1124\/jpet.111.179317","volume":"337","author":"CM Reichel","year":"2011","unstructured":"Reichel CM, Moussawi K, Do PH, Kalivas PW, See RE (2011) Chronic N-acetylcysteine during abstinence or extinction after cocaine self-administration produces enduring reductions in drug seeking. J Pharmacol Exp Ther 337:487\u2013493","journal-title":"J Pharmacol Exp Ther"},{"key":"5211_CR58","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1111\/adb.12127","volume":"20","author":"KJ Reissner","year":"2015","unstructured":"Reissner KJ, Gipson CD, Tran PK, Knackstedt LA, Scofield MD, Kalivas PW (2015) Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Addict Biol 20:316\u2013323","journal-title":"Addict Biol"},{"key":"5211_CR59","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1164\/ajrccm.156.2.9611013","volume":"156","author":"JE Repine","year":"1997","unstructured":"Repine JE, Bast A, Lankhorst I (1997) Oxidative stress in chronic obstructive pulmonary disease. Oxidative Stress Study Group. Am J Resp Crit Care Med 156:341\u2013357","journal-title":"Am J Resp Crit Care Med"},{"key":"5211_CR60","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1126\/science.2820058","volume":"237","author":"MC Ritz","year":"1987","unstructured":"Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ (1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 237:1219\u20131223","journal-title":"Science"},{"key":"5211_CR61","doi-asserted-by":"publisher","first-page":"4117","DOI":"10.1016\/j.bbagen.2013.04.016","volume":"1830","author":"Y Samuni","year":"2013","unstructured":"Samuni Y, Goldstein S, Dean OM, Berk M (2013) The chemistry and biological activities of N-acetylcysteine. Biochim Biophys Acta 1830:4117\u20134129","journal-title":"Biochim Biophys Acta"},{"key":"5211_CR62","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1038\/npp.2012.66","volume":"37","author":"L Schmaal","year":"2012","unstructured":"Schmaal L, Veltman DJ, Nederveen A, van den Brink W, Goudriaan AE (2012) N-acetylcysteine normalizes glutamate levels in cocaine-dependent patients: a randomized crossover magnetic resonance spectroscopy study. Neuropsychopharmacology 37:2143\u20132152","journal-title":"Neuropsychopharmacology"},{"key":"5211_CR63","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.neubiorev.2017.04.013","volume":"78","author":"DR Skvarc","year":"2017","unstructured":"Skvarc DR, Dean OM, Byrne LK, Gray L, Lane S, Lewis M, Fernandes BS, Berk M, Marriott A (2017) The effect of N-acetylcysteine (NAC) on human cognition\u2014a systematic review. Neurosci Biobehav Rev 78:44\u201356","journal-title":"Neurosci Biobehav Rev"},{"key":"5211_CR64","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1016\/j.neubiorev.2013.07.003","volume":"37","author":"DB Spronk","year":"2013","unstructured":"Spronk DB, van Wel JH, Ramaekers JG, Verkes RJ (2013) Characterizing the cognitive effects of cocaine: a comprehensive review. Neurosci Biobehav Rev 37:1838\u20131859","journal-title":"Neurosci Biobehav Rev"},{"key":"5211_CR65","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.jsat.2009.03.009","volume":"37","author":"TH Turner","year":"2009","unstructured":"Turner TH, LaRowe S, Horner MD, Herron J, Malcolm R (2009) Measures of cognitive functioning as predictors of treatment outcome for cocaine dependence. J Subst Abus Treat 37:328\u2013334","journal-title":"J Subst Abus Treat"},{"key":"5211_CR66","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.drugalcdep.2011.09.025","volume":"122","author":"A Verdejo-Garc\u00eda","year":"2012","unstructured":"Verdejo-Garc\u00eda A, Betanzos-Espinosa P, Lozano OM, Vergara-Moragues E, Gonz\u00e1lez-Saiz F, Fern\u00e1ndez-Calder\u00f3n F, Bilbao-Acedos I, P\u00e9rez-Garc\u00eda M (2012) Self-regulation and treatment retention in cocaine dependent individuals: a longitudinal study. Drug Alcohol Depend 122:142\u2013148","journal-title":"Drug Alcohol Depend"},{"key":"5211_CR67","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.jsat.2012.12.005","volume":"44","author":"T Winhusen","year":"2013","unstructured":"Winhusen T, Lewis D, Adinoff B, Brigham G, Kropp F, Donovan DM, Seamans CL, Hodgkins CC, Dicenzo JC, Botero CL, Jones DR, Somoza E (2013a) Impulsivity is associated with treatment non-completion in cocaine- and methamphetamine-dependent patients but differs in nature as a function of stimulant-dependence diagnosis. J Subst Abus Treat 44:541\u2013547","journal-title":"J Subst Abus Treat"},{"key":"5211_CR68","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.drugalcdep.2012.06.017","volume":"127","author":"TM Winhusen","year":"2013","unstructured":"Winhusen TM, Somoza EC, Lewis DF, Kropp FB, Horigian VE, Adinoff B (2013b) Frontal systems deficits in stimulant-dependent patients: evidence of pre-illness dysfunction and relationship to treatment response. Drug Alcohol Depend 127:94\u2013100","journal-title":"Drug Alcohol Depend"},{"key":"5211_CR69","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1124\/pr.112.007054","volume":"66","author":"S Wood","year":"2013","unstructured":"Wood S, Sage JR, Shuman T, Anagnostaras SG (2013) Psychostimulants and cognition: a continuum of behavioral and cognitive activation. Pharmacol Rev 66:193\u2013221","journal-title":"Pharmacol Rev"},{"key":"5211_CR70","first-page":"127","volume":"18","author":"WL Woolverton","year":"1978","unstructured":"Woolverton WL, Schuster CR (1978) Behavioral tolerance to cocaine. NIDA Res Monogr 18:127\u2013141","journal-title":"NIDA Res Monogr"},{"key":"5211_CR71","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.pscychresns.2009.05.004","volume":"174","author":"S Yang","year":"2009","unstructured":"Yang S, Salmeron BJ, Ross TJ, Xi ZX, Stein EA, Yang Y (2009) Lower glutamate levels in rostral anterior cingulate of chronic cocaine users\u2014A (1)H-MRS study using TE-averaged PRESS at 3 T with an optimized quantification strategy. Psychiatry Res 174:171\u2013176","journal-title":"Psychiatry Res"},{"key":"5211_CR72","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.biopsych.2007.06.008","volume":"63","author":"W Zhou","year":"2008","unstructured":"Zhou W, Kalivas PW (2008) N-acetylcysteine reduces extinction responding and induces enduring reductions in cue- and heroin-induced drug-seeking. Biol Psychiatry 63:338\u2013340","journal-title":"Biol Psychiatry"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-019-05211-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-019-05211-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-019-05211-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:02:24Z","timestamp":1606780944000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-019-05211-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,15]]},"references-count":72,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["5211"],"URL":"https:\/\/doi.org\/10.1007\/s00213-019-05211-5","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,15]]},"assertion":[{"value":"6 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The protocol for the present studies was approved by the Institutional Animal Care and Use Committee at McLean Hospital in a facility licensed by the US Department of Agriculture and in accordance with guidelines provided by the Committee on Care and Use of Laboratory Animals of the Institute of Laboratory Animals Resources, Commission on Life Sciences (National Research Council).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}