{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:54:16Z","timestamp":1787910856365,"version":"build-2784847793"},"reference-count":120,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s00213-019-05248-6","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T18:47:51Z","timestamp":1556650071000},"page":"1433-1443","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Gut microbiota and bipolar disorder: a review of mechanisms and potential targets for adjunctive therapy"],"prefix":"10.1007","volume":"236","author":[{"given":"Shakuntla","family":"Gondalia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Parkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Con","family":"Stough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Scholey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,4,30]]},"reference":[{"key":"5248_CR1","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.nut.2015.09.003","volume":"32","author":"G Akkasheh","year":"2016","unstructured":"Akkasheh G, Kashani-Poor Z, Tajabadi-Ebrahimi M et al (2016) Clinical and metabolic response to probiotic administration in patients with major depressive disorder: a randomized, double-blind, placebo-controlled trial. Nutrition 32:315\u2013320. \nhttps:\/\/doi.org\/10.1016\/j.nut.2015.09.003","journal-title":"Nutrition"},{"key":"5248_CR2","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1016\/j.jff.2015.05.018","volume":"18","author":"N Alshikh","year":"2015","unstructured":"Alshikh N, de Camargo AC, Shahidi F (2015) Phenolics of selected lentil cultivars: Antioxidant activities and inhibition of low-density lipoprotein and DNA damage. J Funct Foods 18:1022\u20131038","journal-title":"J Funct Foods"},{"key":"5248_CR3","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s00418-013-1081-1","volume":"139","author":"E Asan","year":"2013","unstructured":"Asan E, Steinke M, Lesch K-P (2013) Serotonergic innervation of the amygdala: targets, receptors, and implications for stress and anxiety. Histochem Cell Biol 139:785\u2013813. \nhttps:\/\/doi.org\/10.1007\/s00418-013-1081-1","journal-title":"Histochem Cell Biol"},{"key":"5248_CR4","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/j.1749-6632.1997.tb52359.x","volume":"836","author":"M \u00c5sberg","year":"1997","unstructured":"\u00c5sberg M (1997) Neurotransmitters and suicidal behavior. Ann N Y Acad Sci 836:158\u2013181","journal-title":"Ann N Y Acad Sci"},{"key":"5248_CR5","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jad.2013.12.042","volume":"157","author":"IG Barbosa","year":"2014","unstructured":"Barbosa IG, Morato IB, de Miranda AS, Bauer ME, Soares JC, Teixeira AL (2014) A preliminary report of increased plasma levels of IL-33 in bipolar disorder: further evidence of pro-inflammatory status. J Affect Disord 157:41\u201344","journal-title":"J Affect Disord"},{"issue":"2","key":"5248_CR6","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/j.1365-2672.2012.05344.x","volume":"113","author":"E. Barrett","year":"2012","unstructured":"Barrett E, Ross RP, O'Toole PW, Fitzgerald GF, Stanton C (2012) \u00ce\u00b3-Aminobutyric acid production by culturable bacteria from the human intestine. J Appl Microbiol 113 (2):411\u2013417","journal-title":"Journal of Applied Microbiology"},{"key":"5248_CR7","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1001\/jamapsychiatry.2013.1111","volume":"70","author":"ME Benros","year":"2013","unstructured":"Benros ME, Waltoft BL, Nordentoft M, \u00d8stergaard SD, Eaton WW, Krogh J, Mortensen PB (2013) Autoimmune diseases and severe infections as risk factors for mood disorders: a nationwide study. JAMA Psychiatry 70:812\u2013820","journal-title":"JAMA Psychiatry"},{"key":"5248_CR8","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/sj.ejcn.1602546","volume":"61","author":"D Benton","year":"2007","unstructured":"Benton D, Williams C, Brown A (2007) Impact of consuming a milk drink containing a probiotic on mood and cognition. Eur J Clin Nutr 61:355","journal-title":"Eur J Clin Nutr"},{"key":"5248_CR9","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1111\/j.1365-2982.2011.01796.x","volume":"23","author":"P Bercik","year":"2011","unstructured":"Bercik P, Park A, Sinclair D et al (2011) The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut\u2013brain communication. Neurogastroenterol Motil 23:1132\u20131139","journal-title":"Neurogastroenterol Motil"},{"key":"5248_CR10","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.neubiorev.2010.10.001","volume":"35","author":"M Berk","year":"2011","unstructured":"Berk M, Kapczinski F, Andreazza A et al (2011) Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev 35:804\u2013817","journal-title":"Neurosci Biobehav Rev"},{"key":"5248_CR11","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1097\/PSY.0b013e3181f61863","volume":"72","author":"MA Beydoun","year":"2010","unstructured":"Beydoun MA, Shroff MR, Beydoun HA, Zonderman AB (2010) Serum folate, vitamin B-12 and homocysteine and their association with depressive symptoms among US adults. Psychosom Med 72:862\u2013873","journal-title":"Psychosom Med"},{"key":"5248_CR12","doi-asserted-by":"publisher","first-page":"S95","DOI":"10.1079\/BJN2002634","volume":"88","author":"A Bomba","year":"2002","unstructured":"Bomba A, Nemcova R, Gancarcikova S, Herich R, Guba P, Mudronova D (2002) Improvement of the probiotic effect of micro-organisms by their combination with maltodextrins, fructo-oligosaccharides and polyunsaturated fatty acids. Br J Nutr 88:S95\u2013S99","journal-title":"Br J Nutr"},{"key":"5248_CR13","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.jad.2004.01.007","volume":"82","author":"F Boufidou","year":"2004","unstructured":"Boufidou F, Nikolaou C, Alevizos B, Liappas IA, Christodoulou GN (2004) Cytokine production in bipolar affective disorder patients under lithium treatment. J Affect Disord 82:309\u2013313","journal-title":"J Affect Disord"},{"key":"5248_CR14","doi-asserted-by":"publisher","first-page":"16050","DOI":"10.1073\/pnas.1102999108","volume":"108","author":"JA Bravo","year":"2011","unstructured":"Bravo JA, Forsythe P, Chew MV et al (2011) Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci 108:16050\u201316055","journal-title":"Proc Natl Acad Sci"},{"key":"5248_CR15","doi-asserted-by":"publisher","first-page":"1046s","DOI":"10.1093\/ajcn\/69.5.1046s","volume":"69","author":"JJ Cebra","year":"1999","unstructured":"Cebra JJ (1999) Influences of microbiota on intestinal immune system development. Am J Clin Nutr 69:1046s\u20131051s. \nhttps:\/\/doi.org\/10.1093\/ajcn\/69.5.1046s","journal-title":"Am J Clin Nutr"},{"key":"5248_CR16","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/nrgastro.2014.40","volume":"11","author":"SM Collins","year":"2014","unstructured":"Collins SM (2014) A role for the gut microbiota in IBS. Nat Rev Gastroenterol Hepatol 11:497\u2013505. \nhttps:\/\/doi.org\/10.1038\/nrgastro.2014.40","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"5248_CR17","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/nrn3346","volume":"13","author":"JF Cryan","year":"2012","unstructured":"Cryan JF, Dinan TG (2012) Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13:701\u2013712. \nhttps:\/\/doi.org\/10.1038\/nrn3346","journal-title":"Nat Rev Neurosci"},{"key":"5248_CR18","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/s00406-007-0797-0","volume":"258","author":"AB Cunha","year":"2008","unstructured":"Cunha AB, Andreazza AC, Gomes FA, Frey BN, Da Silveira LE, Gon\u00e7alves CA, Kapczinski F (2008) Investigation of serum high-sensitive C-reactive protein levels across all mood states in bipolar disorder. Eur Arch Psychiatry Clin Neurosci 258:300\u2013304","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"5","key":"5248_CR19","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1007\/s00213-018-5006-5","volume":"236","author":"Sofia Cussotto","year":"2018","unstructured":"Cussotto S, Strain CR, Fouhy F et al (2018) Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function. Psychopharmacology. \nhttps:\/\/doi.org\/10.1007\/s00213-018-5006-5","journal-title":"Psychopharmacology"},{"issue":"02","key":"5248_CR20","doi-asserted-by":"publisher","first-page":"142","DOI":"10.4088\/JCP.14r09007","volume":"76","author":"Aroldo A. Darg\u00e9l","year":"2015","unstructured":"Darg\u00e9l AA, Godin O, Kapczinski F, Kupfer DJ, Leboyer M (2015) C-reactive protein alterations in bipolar disorder: a meta-analysis. J Clin Psychiatry: 76(2):142\u2013150","journal-title":"The Journal of Clinical Psychiatry"},{"key":"5248_CR21","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1177\/070674371205700205","volume":"57","author":"KM Davison","year":"2012","unstructured":"Davison KM, Kaplan BJ (2012) Nutrient intakes are correlated with overall psychiatric functioning in adults with mood disorders. Can J Psychiatry 57:85\u201392","journal-title":"Can J Psychiatry"},{"key":"5248_CR22","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1371\/journal.pcbi.0040004","volume":"4","author":"P Dayan","year":"2008","unstructured":"Dayan P, Huys QJ (2008) Serotonin, inhibition, and negative mood. PLoS Comput Biol 4:e4. \nhttps:\/\/doi.org\/10.1371\/journal.pcbi.0040004","journal-title":"PLoS Comput Biol"},{"key":"5248_CR23","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1016\/j.pnpbp.2007.02.018","volume":"31","author":"F Dickerson","year":"2007","unstructured":"Dickerson F, Stallings C, Origoni A, Boronow J, Yolken R (2007) Elevated serum levels of C-reactive protein are associated with mania symptoms in outpatients with bipolar disorder. Prog Neuro-Psychopharmacol Biol Psychiatry 31:952\u2013955","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"5248_CR24","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/acps.12451","volume":"132","author":"F Dickerson","year":"2015","unstructured":"Dickerson F, Katsafanas E, Schweinfurth L et al (2015) Immune alterations in acute bipolar depression. Acta Psychiatr Scand 132:204\u2013210","journal-title":"Acta Psychiatr Scand"},{"key":"5248_CR25","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1111\/bdi.12652","volume":"20","author":"F Dickerson","year":"2018","unstructured":"Dickerson F, Adamos M, Katsafanas E et al (2018) Adjunctive probiotic microorganisms to prevent rehospitalization in patients with acute mania: a randomized controlled trial. Bipolar Disord 20:614\u2013621. \nhttps:\/\/doi.org\/10.1111\/bdi.12652","journal-title":"Bipolar Disord"},{"key":"5248_CR26","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1586\/ern.09.144","volume":"10","author":"RC Drexhage","year":"2010","unstructured":"Drexhage RC, Knijff EM, Padmos RC, Heul-Nieuwenhuijzen L, Beumer W, Versnel MA, Drexhage HA (2010) The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder. Expert Rev Neurother 10:59\u201376","journal-title":"Expert Rev Neurother"},{"key":"5248_CR27","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/S0091-3057(02)01024-9","volume":"74","author":"CG Engeland","year":"2003","unstructured":"Engeland CG, Kavaliers M, Ossenkopp K-P (2003) Sex differences in the effects of muramyl dipeptide and lipopolysaccharide on locomotor activity and the development of behavioral tolerance in rats. Pharmacol Biochem Behav 74:433\u2013447","journal-title":"Pharmacol Biochem Behav"},{"key":"5248_CR28","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jpsychires.2016.12.007","volume":"87","author":"SJ Evans","year":"2017","unstructured":"Evans SJ, Bassis CM, Hein R, Assari S, Flowers SA, Kelly MB, Young VB, Ellingrod VE, McInnis MG (2017) The gut microbiome composition associates with bipolar disorder and illness severity. J Psychiatr Res 87:23\u201329. \nhttps:\/\/doi.org\/10.1016\/j.jpsychires.2016.12.007","journal-title":"J Psychiatr Res"},{"key":"5248_CR29","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00406-014-0502-z","volume":"264","author":"G Fond","year":"2014","unstructured":"Fond G, Loundou A, Hamdani N, Boukouaci W, Dargel A, Oliveira J, Roger M, Tamouza R, Leboyer M, Boyer L (2014) Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis. Eur Arch Psychiatry Clin Neurosci 264:651\u2013660","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"5248_CR30","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1192\/bjp.188.1.46","volume":"188","author":"S Frangou","year":"2006","unstructured":"Frangou S, Lewis M, McCrone P (2006) Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled study. Br J Psychiatry 188:46\u201350","journal-title":"Br J Psychiatry"},{"key":"5248_CR31","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3892\/etm.2013.1101","volume":"6","author":"J Gao","year":"2013","unstructured":"Gao J (2013) Correlation between anxiety-depression status and cytokines in diarrhea-predominant irritable bowel syndrome. Exp Ther Med 6:93\u201396","journal-title":"Exp Ther Med"},{"key":"5248_CR32","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1111\/j.1365-2036.2009.03942.x","volume":"29","author":"S Garud","year":"2009","unstructured":"Garud S, Leffler D, Dennis M et al (2009) Interaction between psychiatric and autoimmune disorders in coeliac disease patients in the Northeastern United States. Aliment Pharmacol Ther 29:898\u2013905","journal-title":"Aliment Pharmacol Ther"},{"key":"5248_CR33","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/S0140-6736(13)60857-0","volume":"381","author":"JR Geddes","year":"2013","unstructured":"Geddes JR, Miklowitz DJ (2013) Treatment of bipolar disorder. Lancet 381:1672\u20131682","journal-title":"Lancet"},{"key":"5248_CR34","unstructured":"Gerner RH, Post RM, Bunney WE (1976) A dopaminergic mechanism in mania. Am J Psychiatry 133(10):1177\u20131180"},{"key":"5248_CR35","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jbtep.2014.07.005","volume":"46","author":"A Gershon","year":"2015","unstructured":"Gershon A, Eidelman P (2015) Inter-episode affective intensity and instability: predictors of depression and functional impairment in bipolar disorder. J Behav Ther Exp Psychiatry 46:14\u201318","journal-title":"J Behav Ther Exp Psychiatry"},{"key":"5248_CR36","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1176\/ajp.152.11.1635","volume":"152","author":"MJ Gitlin","year":"1995","unstructured":"Gitlin MJ, Swendsen J, Heller TL, Hammen C (1995) Relapse and impairment in bipolar disorder. Am J Psychiatry 152:1635","journal-title":"Am J Psychiatry"},{"key":"5248_CR37","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.bbi.2007.08.009","volume":"22","author":"LE Goehler","year":"2008","unstructured":"Goehler LE, Park SM, Opitz N, Lyte M, Gaykema RP (2008) Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: possible anatomical substrates for viscerosensory modulation of exploratory behavior. Brain Behav Immun 22:354\u2013366","journal-title":"Brain Behav Immun"},{"key":"5248_CR38","first-page":"1078, 1090","volume":"70","author":"BI Goldstein","year":"2009","unstructured":"Goldstein BI, Kemp DE, Soczynska JK, McIntyre RS (2009) Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature. J Clin Psychiatry 70:1078, 1090","journal-title":"J Clin Psychiatry"},{"key":"5248_CR39","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1089\/cap.2011.0009","volume":"21","author":"BI Goldstein","year":"2011","unstructured":"Goldstein BI, Collinger KA, Lotrich F, Marsland AL, Gill M-K, Axelson DA, Birmaher B (2011) Preliminary findings regarding proinflammatory markers and brain-derived neurotrophic factor among adolescents with bipolar spectrum disorders. J Child Adolesc Psychopharmacol 21:479\u2013484","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"5248_CR40","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1126\/science.aad2571","volume":"351","author":"M Gomez de Ag\u00fcero","year":"2016","unstructured":"Gomez de Ag\u00fcero M, Ganal-Vonarburg SC, Fuhrer T et al (2016) The maternal microbiota drives early postnatal innate immune development. Science 351:1296\u20131302. \nhttps:\/\/doi.org\/10.1126\/science.aad2571","journal-title":"Science"},{"key":"5248_CR41","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/j.1399-5618.2010.00799.x","volume":"12","author":"BL Gracious","year":"2010","unstructured":"Gracious BL, Chirieac MC, Costescu S, Finucane TL, Youngstrom EA, Hibbeln JR (2010) Randomized, placebo-controlled trial of flax oil in pediatric bipolar disorder. Bipolar Disord 12:142\u2013154","journal-title":"Bipolar Disord"},{"key":"5248_CR42","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s11920-013-0387-y","volume":"15","author":"N Hamdani","year":"2013","unstructured":"Hamdani N, Doukhan R, Kurtlucan O, Tamouza R, Leboyer M (2013) Immunity, inflammation, and bipolar disorder: diagnostic and therapeutic implications. Curr Psychiatry Rep 15:387","journal-title":"Curr Psychiatry Rep"},{"key":"5248_CR43","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1177\/0004867415595873","volume":"49","author":"N Hamdani","year":"2015","unstructured":"Hamdani N, Boukouaci W, Hallouche MR, Charron D, Krishnamoorthy R, Leboyer M, Tamouza R (2015) Resolution of a manic episode treated with activated charcoal: Evidence for a brain\u2013gut axis in bipolar disorder. Aust N Z J Psychiatry 49:1221\u20131223","journal-title":"Aust N Z J Psychiatry"},{"key":"5248_CR44","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1016\/j.jpsychires.2011.08.003","volume":"45","author":"S Hope","year":"2011","unstructured":"Hope S, Dieset I, Agartz I et al (2011) Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia. J Psychiatr Res 45:1608\u20131616","journal-title":"J Psychiatr Res"},{"key":"5248_CR45","doi-asserted-by":"publisher","first-page":"501","DOI":"10.5114\/aoms.2011.23418","volume":"7","author":"NA Ismail","year":"2011","unstructured":"Ismail NA, Ragab SH, ElBaky AA, Shoeib AR, Alhosary Y, Fekry D (2011) Frequency of Firmicutes and Bacteroidetes in gut microbiota in obese and normal weight Egyptian children and adults. Arch Med Sci 7:501","journal-title":"Arch Med Sci"},{"key":"5248_CR46","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1176\/appi.ajp.2009.09060881","volume":"167","author":"FN Jacka","year":"2010","unstructured":"Jacka FN, Pasco JA, Mykletun A et al (2010) Association of Western and traditional diets with depression and anxiety in women. Am J Psychiatr 167:305\u2013311","journal-title":"Am J Psychiatr"},{"key":"5248_CR47","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.jad.2010.09.004","volume":"129","author":"FN Jacka","year":"2011","unstructured":"Jacka FN, Pasco JA, Mykletun A, Williams LJ, Nicholson GC, Kotowicz MA, Berk M (2011) Diet quality in bipolar disorder in a population-based sample of women. J Affect Disord 129:332\u2013337","journal-title":"J Affect Disord"},{"key":"5248_CR48","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12916-017-0791-y","volume":"15","author":"FN Jacka","year":"2017","unstructured":"Jacka FN, O\u2019Neil A, Opie R et al (2017) A randomised controlled trial of dietary improvement for adults with major depression (the \u2018SMILES\u2019 trial). BMC Med 15:23","journal-title":"BMC Med"},{"key":"5248_CR49","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1017\/S0033291700009132","volume":"16","author":"D Jacobs","year":"1986","unstructured":"Jacobs D, Silverstone T (1986) Dextroamphetamine-induced arousal in human subjects as a model for mania. Psychol Med 16:323\u2013329","journal-title":"Psychol Med"},{"key":"5248_CR50","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jpsychires.2010.05.015","volume":"45","author":"F Kapczinski","year":"2011","unstructured":"Kapczinski F, Dal-Pizzol F, Teixeira AL et al (2011) Peripheral biomarkers and illness activity in bipolar disorder. J Psychiatr Res 45:156\u2013161","journal-title":"J Psychiatr Res"},{"key":"5248_CR51","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jad.2007.02.018","volume":"104","author":"Y-K Kim","year":"2007","unstructured":"Kim Y-K, Jung H-G, Myint A-M, Kim H, Park S-H (2007) Imbalance between pro-inflammatory and anti-inflammatory cytokines in bipolar disorder. J Affect Disord 104:91\u201395","journal-title":"J Affect Disord"},{"key":"5248_CR52","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/acps.12671","volume":"135","author":"O K\u00f6hler","year":"2017","unstructured":"K\u00f6hler O, Petersen L, Mors O, Mortensen P, Yolken R, Gasse C, Benros M (2017) Infections and exposure to anti-infective agents and the risk of severe mental disorders: a nationwide study. Acta Psychiatr Scand 135:97\u2013105","journal-title":"Acta Psychiatr Scand"},{"key":"5248_CR53","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1111\/jdv.14460","volume":"31","author":"J Koo","year":"2017","unstructured":"Koo J, Marangell LB, Nakamura M, Armstrong A, Jeon C, Bhutani T, Wu JJ (2017) Depression and suicidality in psoriasis: review of the literature including the cytokine theory of depression. J Eur Acad Dermatol Venereol 31:1999\u20132009. \nhttps:\/\/doi.org\/10.1111\/jdv.14460","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"5248_CR54","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cgh.2011.08.015","volume":"10","author":"U Ladabaum","year":"2012","unstructured":"Ladabaum U, Boyd E, Zhao WK, Mannalithara A, Sharabidze A, Singh G, Chung E, Levin TR (2012) Diagnosis, comorbidities, and management of irritable bowel syndrome in patients in a large health maintenance organization. Clin Gastroenterol Hepatol 10:37\u201345","journal-title":"Clin Gastroenterol Hepatol"},{"key":"5248_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jad.2011.12.049","volume":"141","author":"M Leboyer","year":"2012","unstructured":"Leboyer M, Soreca I, Scott J, Frye M, Henry C, Tamouza R, Kupfer DJ (2012) Can bipolar disorder be viewed as a multi-system inflammatory disease? J Affect Disord 141:1\u201310","journal-title":"J Affect Disord"},{"key":"5248_CR56","doi-asserted-by":"publisher","first-page":"e0133283","DOI":"10.1371\/journal.pone.0133283","volume":"10","author":"Y-T Lee","year":"2015","unstructured":"Lee Y-T, Hu L-Y, Shen C-C et al (2015) Risk of psychiatric disorders following irritable bowel syndrome: a nationwide population-based cohort study. PLoS One 10:e0133283","journal-title":"PLoS One"},{"key":"5248_CR57","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.encep.2015.06.008","volume":"43","author":"T Legendre","year":"2017","unstructured":"Legendre T, Boudebesse C, Henry C, Etain B (2017) Antibiomania: think of the manic syndrome secondary to antibiotic therapy. Encephale 43:183\u2013186","journal-title":"Encephale"},{"key":"5248_CR58","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.neubiorev.2011.12.005","volume":"36","author":"B Leonard","year":"2012","unstructured":"Leonard B, Maes M (2012) Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neurosci Biobehav Rev 36:764\u2013785","journal-title":"Neurosci Biobehav Rev"},{"key":"5248_CR59","doi-asserted-by":"publisher","first-page":"e0118209","DOI":"10.1371\/journal.pone.0118209","volume":"10","author":"C-J Liu","year":"2015","unstructured":"Liu C-J, Hu L-Y, Yeh C-M, Hu Y-W, Chen P-M, Chen T-J, Lu T (2015) Irritable brain caused by irritable bowel? A nationwide analysis for irritable bowel syndrome and risk of bipolar disorder. PLoS One 10:e0118209","journal-title":"PLoS One"},{"key":"5248_CR60","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1089\/acm.2015.0125","volume":"21","author":"AL Lopresti","year":"2015","unstructured":"Lopresti AL, Jacka FN (2015) Diet and bipolar disorder: a review of its relationship and potential therapeutic mechanisms of action. J Altern Complement Med 21:733\u2013739","journal-title":"J Altern Complement Med"},{"issue":"8","key":"5248_CR61","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1002\/bies.201100024","volume":"33","author":"Mark Lyte","year":"2011","unstructured":"Lyte M (2011) Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics. BioEssays 33(8):574\u2013581","journal-title":"BioEssays"},{"key":"5248_CR62","first-page":"287","volume":"29","author":"M Maes","year":"2008","unstructured":"Maes M (2008) The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression. Neuro Endocrinol Lett 29:287\u2013291","journal-title":"Neuro Endocrinol Lett"},{"key":"5248_CR63","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/j.1600-0447.2011.01794.x","volume":"125","author":"P Magalhaes","year":"2012","unstructured":"Magalhaes P, Kapczinski F, Nierenberg A, Deckersbach T, Weisinger D, Dodd S, Berk M (2012) Illness burden and medical comorbidity in the Systematic Treatment Enhancement Program for Bipolar Disorder. Acta Psychiatr Scand 125:303\u2013308","journal-title":"Acta Psychiatr Scand"},{"key":"5248_CR64","first-page":"117","volume":"29","author":"M Mass","year":"2008","unstructured":"Mass M, Kubera M, Leunis J-C (2008) The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuroendocrinol Lett 29:117\u2013124","journal-title":"Neuroendocrinol Lett"},{"key":"5248_CR65","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1172\/JCI76304","volume":"125","author":"EA Mayer","year":"2015","unstructured":"Mayer EA, Tillisch K, Gupta A (2015) Gut\/brain axis and the microbiota. J Clin Invest 125:926\u2013938. \nhttps:\/\/doi.org\/10.1172\/JCI76304","journal-title":"J Clin Invest"},{"key":"5248_CR66","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1080\/07315724.2015.1080527","volume":"34","author":"RK McNamara","year":"2015","unstructured":"McNamara RK (2015) Mitigation of inflammation-induced mood dysregulation by long-chain omega-3 fatty acids. J Am Coll Nutr 34:48\u201355","journal-title":"J Am Coll Nutr"},{"key":"5248_CR67","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/S0361-9230(01)00523-8","volume":"55","author":"JH Meador-Woodruff","year":"2001","unstructured":"Meador-Woodruff JH, Hogg AJ Jr, Smith RE (2001) Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder. Brain Res Bull 55:631\u2013640","journal-title":"Brain Res Bull"},{"issue":"4","key":"5248_CR68","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/S0306-4522(02)00123-9","volume":"112","author":"R Molteni","year":"2002","unstructured":"Molteni R, Barnard RJ, Ying Z, Roberts CK, Gomez-Pinilla F (2002) A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience 112(4):803\u2013814","journal-title":"Neuroscience"},{"key":"5248_CR69","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.schres.2004.02.016","volume":"71","author":"HT Mueller","year":"2004","unstructured":"Mueller HT, Meador-Woodruff JH (2004) NR3A NMDA receptor subunit mRNA expression in schizophrenia, depression and bipolar disorder. Schizophr Res 71:361\u2013370","journal-title":"Schizophr Res"},{"key":"5248_CR70","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jad.2012.06.010","volume":"144","author":"K Munkholm","year":"2013","unstructured":"Munkholm K, Vinberg M, Kessing LV (2013) Cytokines in bipolar disorder: a systematic review and meta-analysis. J Affect Disord 144:16\u201327","journal-title":"J Affect Disord"},{"key":"5248_CR71","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1097\/JCP.0b013e318266854c","volume":"32","author":"BL Murphy","year":"2012","unstructured":"Murphy BL, Stoll AL, Harris PQ, Ravichandran C, Babb SM, Carlezon WA Jr, Cohen BM (2012) Omega-3 fatty acid treatment, with or without cytidine, fails to show therapeutic properties in bipolar disorder: a double-blind, randomized add-on clinical trial. J Clin Psychopharmacol 32:699\u2013703","journal-title":"J Clin Psychopharmacol"},{"key":"5248_CR72","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jad.2006.12.008","volume":"102","author":"AM Myint","year":"2007","unstructured":"Myint AM, Kim Y-K, Verkerk R, Park SH, Scharp\u00e9 S, Steinbusch HWM, Leonard BE (2007) Tryptophan breakdown pathway in bipolar mania. J Affect Disord 102:65\u201372. \nhttps:\/\/doi.org\/10.1016\/j.jad.2006.12.008","journal-title":"J Affect Disord"},{"key":"5248_CR73","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/1471-230X-10-88","volume":"10","author":"A Mykletun","year":"2010","unstructured":"Mykletun A, Jacka F, Williams L et al (2010) Prevalence of mood and anxiety disorder in self reported irritable bowel syndrome (IBS). An epidemiological population based study of women. BMC Gastroenterol 10:88","journal-title":"BMC Gastroenterol"},{"key":"5248_CR74","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1093\/schbul\/sbt200","volume":"40","author":"PR Nielsen","year":"2013","unstructured":"Nielsen PR, Benros ME, Mortensen PB (2013) Hospital contacts with infection and risk of schizophrenia: a population-based cohort study with linkage of Danish national registers. Schizophr Bull 40:1526\u20131532","journal-title":"Schizophr Bull"},{"key":"5248_CR75","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.bbr.2014.07.027","volume":"277","author":"SM O\u2019Mahony","year":"2015","unstructured":"O\u2019Mahony SM, Clarke G, Borre YE, Dinan TG, Cryan JF (2015) Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res 277:32\u201348. \nhttps:\/\/doi.org\/10.1016\/j.bbr.2014.07.027","journal-title":"Behav Brain Res"},{"key":"5248_CR76","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/1471-244X-13-114","volume":"13","author":"A O\u2019Neil","year":"2013","unstructured":"O\u2019Neil A, Berk M, Itsiopoulos C et al (2013) A randomised, controlled trial of a dietary intervention for adults with major depression (the \u201cSMILES\u201d trial): study protocol. BMC Psychiatry 13:114","journal-title":"BMC Psychiatry"},{"issue":"1","key":"5248_CR77","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/bdi.12682","volume":"21","author":"Annamaria Painold","year":"2018","unstructured":"Painold A, M\u00f6rkl S, Kashofer K et al (2018) A step ahead: exploring the gut microbiota in inpatients with bipolar disorder during a depressive episode. Bipolar Disord. \nhttps:\/\/doi.org\/10.1111\/bdi.12682","journal-title":"Bipolar Disorders"},{"key":"5248_CR78","doi-asserted-by":"publisher","first-page":"12323","DOI":"10.3390\/ijms150712323","volume":"15","author":"L Parkinson","year":"2014","unstructured":"Parkinson L, Keast R (2014) Oleocanthal, a phenolic derived from virgin olive oil: a review of the beneficial effects on inflammatory disease. Int J Mol Sci 15:12323\u201312334","journal-title":"Int J Mol Sci"},{"key":"5248_CR79","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1176\/appi.ajp.163.2.217","volume":"163","author":"RH Perlis","year":"2006","unstructured":"Perlis RH, Ostacher MJ, Patel JK et al (2006) Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatr 163:217\u2013224","journal-title":"Am J Psychiatr"},{"key":"5248_CR80","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1053\/j.gastro.2017.05.003","volume":"153","author":"MI Pinto-Sanchez","year":"2017","unstructured":"Pinto-Sanchez MI, Hall GB, Ghajar K et al (2017) Probiotic Bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: a pilot study in patients with irritable bowel syndrome. Gastroenterology 153:448\u2013459 e448. \nhttps:\/\/doi.org\/10.1053\/j.gastro.2017.05.003","journal-title":"Gastroenterology"},{"key":"5248_CR81","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/bdi.12087","volume":"15","author":"M Pompili","year":"2013","unstructured":"Pompili M, Gonda X, Serafini G et al (2013) Epidemiology of suicide in bipolar disorders: a systematic review of the literature. Bipolar Disord 15:457\u2013490","journal-title":"Bipolar Disord"},{"key":"5248_CR82","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.jpsychires.2006.09.009","volume":"41","author":"RM Post","year":"2007","unstructured":"Post RM (2007) Role of BDNF in bipolar and unipolar disorder: clinical and theoretical implications. J Psychiatr Res 41:979\u2013990","journal-title":"J Psychiatr Res"},{"key":"5248_CR83","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1007\/s00394-014-0652-9","volume":"53","author":"C Rahe","year":"2014","unstructured":"Rahe C, Unrath M, Berger K (2014) Dietary patterns and the risk of depression in adults: a systematic review of observational studies. Eur J Nutr 53:997\u20131013","journal-title":"Eur J Nutr"},{"key":"5248_CR84","doi-asserted-by":"publisher","first-page":"881","DOI":"10.3945\/jn.113.189407","volume":"144","author":"J Reedy","year":"2014","unstructured":"Reedy J, Krebs-Smith SM, Miller PE, Liese AD, Kahle LL, Park Y, Subar AF (2014) Higher diet quality is associated with decreased risk of all-cause, cardiovascular disease, and cancer mortality among older adults. J Nutr 144:881\u2013889","journal-title":"J Nutr"},{"key":"5248_CR85","doi-asserted-by":"publisher","unstructured":"Reininghaus EZ, Wetzlmair LC, Fellendorf FT et al (2018) The impact of probiotic supplements on cognitive parameters in euthymic individuals with bipolar disorder: a pilot study. Neuropsychobiology:1\u20138. \nhttps:\/\/doi.org\/10.1159\/000492537","DOI":"10.1159\/000492537"},{"key":"5248_CR86","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1177\/0004867416686694","volume":"51","author":"AR Romijn","year":"2017","unstructured":"Romijn AR, Rucklidge JJ, Kuijer RG, Frampton C (2017) A double-blind, randomized, placebo-controlled trial of Lactobacillus helveticus and Bifidobacterium longum for the symptoms of depression. Aust N Z J Psychiatry 51:810\u2013821. \nhttps:\/\/doi.org\/10.1177\/0004867416686694","journal-title":"Aust N Z J Psychiatry"},{"issue":"8","key":"5248_CR87","doi-asserted-by":"publisher","first-page":"e1002533","DOI":"10.1371\/journal.pbio.1002533","volume":"14","author":"Ron Sender","year":"2016","unstructured":"Ron Sender, Shai Fuchs, Ron Milo, (2016) Revised estimates for the number of human and bacteria cells in the body. PLOS Biology 14 (8):e1002533","journal-title":"PLOS Biology"},{"key":"5248_CR88","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1111\/j.1758-2229.2010.00177.x","volume":"2","author":"E Rosenberg","year":"2010","unstructured":"Rosenberg E, Sharon G, Atad I, Zilber-Rosenberg I (2010) The evolution of animals and plants via symbiosis with microorganisms. Environ Microbiol Rep 2:500\u2013506. \nhttps:\/\/doi.org\/10.1111\/j.1758-2229.2010.00177.x","journal-title":"Environ Microbiol Rep"},{"key":"5248_CR89","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/bdi.12373","volume":"18","author":"JD Rosenblat","year":"2016","unstructured":"Rosenblat JD, Kakar R, Berk M et al (2016) Anti-inflammatory agents in the treatment of bipolar depression: a systematic review and meta-analysis. Bipolar Disord 18:89\u2013101. \nhttps:\/\/doi.org\/10.1111\/bdi.12373","journal-title":"Bipolar Disord"},{"key":"5248_CR90","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1176\/ps.2009.60.2.147","volume":"60","author":"B Roshanaei-Moghaddam","year":"2009","unstructured":"Roshanaei-Moghaddam B, Katon W (2009) Premature mortality from general medical illnesses among persons with bipolar disorder: a review. Psychiatr Serv 60:147\u2013156","journal-title":"Psychiatr Serv"},{"key":"5248_CR91","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nri2515","volume":"9","author":"JL Round","year":"2009","unstructured":"Round JL, Mazmanian SK (2009) The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 9:313\u2013323. \nhttps:\/\/doi.org\/10.1038\/nri2515","journal-title":"Nat Rev Immunol"},{"key":"5248_CR92","first-page":"1","volume":"1","author":"GS Sachs","year":"2000","unstructured":"Sachs GS, Printz DJ, Kahn DA, Carpenter D, Docherty JP (2000) The expert consensus guideline series: medication treatment of bipolar disorder. Postgrad Med 1:1\u2013104","journal-title":"Postgrad Med"},{"key":"5248_CR93","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.chom.2015.04.011","volume":"17","author":"TR Sampson","year":"2015","unstructured":"Sampson TR, Mazmanian SK (2015) Control of brain development, function, and behavior by the microbiome. Cell Host Microbe 17:565\u2013576. \nhttps:\/\/doi.org\/10.1016\/j.chom.2015.04.011","journal-title":"Cell Host Microbe"},{"key":"5248_CR94","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1001\/archgenpsychiatry.2009.129","volume":"66","author":"A S\u00e1nchez-Villegas","year":"2009","unstructured":"S\u00e1nchez-Villegas A, Delgado-Rodr\u00edguez M, Alonso A, Schlatter J, Lahortiga F, Majem LS, Mart\u00ednez-Gonz\u00e1lez MA (2009) Association of the Mediterranean dietary pattern with the incidence of depression: the Seguimiento Universidad de Navarra\/University of Navarra follow-up (SUN) cohort. Arch Gen Psychiatry 66:1090\u20131098","journal-title":"Arch Gen Psychiatry"},{"key":"5248_CR95","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1179\/1476830511Y.0000000011","volume":"14","author":"A S\u00e1nchez-Villegas","year":"2011","unstructured":"S\u00e1nchez-Villegas A, Galbete C, Martinez-Gonz\u00e1lez M\u00c1 et al (2011) The effect of the Mediterranean diet on plasma brain-derived neurotrophic factor (BDNF) levels: the PREDIMED-NAVARRA randomized trial. Nutr Neurosci 14:195\u2013201","journal-title":"Nutr Neurosci"},{"key":"5248_CR96","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s40168-017-0297-z","volume":"5","author":"MK Saraf","year":"2017","unstructured":"Saraf MK, Piccolo BD, Bowlin AK, Mercer KE, LeRoith T, Chintapalli SV, Shankar K, Badger TM, Yeruva L (2017) Formula diet driven microbiota shifts tryptophan metabolism from serotonin to tryptamine in neonatal porcine colon. Microbiome 5:77. \nhttps:\/\/doi.org\/10.1186\/s40168-017-0297-z","journal-title":"Microbiome"},{"key":"5248_CR97","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S2215-0366(14)00051-0","volume":"2","author":"J Sarris","year":"2015","unstructured":"Sarris J, Logan AC, Akbaraly TN et al (2015a) Nutritional medicine as mainstream in psychiatry. Lancet Psychiatry 2:271\u2013274","journal-title":"Lancet Psychiatry"},{"key":"5248_CR98","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1002\/wps.20223","volume":"14","author":"J Sarris","year":"2015","unstructured":"Sarris J, Logan AC, Akbaraly TN et al (2015b) International Society for Nutritional Psychiatry Research consensus position statement: nutritional medicine in modern psychiatry. World Psychiatry 14:370\u2013371","journal-title":"World Psychiatry"},{"key":"5248_CR99","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1007\/s00213-014-3810-0","volume":"232","author":"K Schmidt","year":"2015","unstructured":"Schmidt K, Cowen PJ, Harmer CJ, Tzortzis G, Errington S, Burnet PW (2015) Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology 232:1793\u20131801. \nhttps:\/\/doi.org\/10.1007\/s00213-014-3810-0","journal-title":"Psychopharmacology"},{"key":"5248_CR100","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1017\/S0029665117004025","volume":"77","author":"A Scholey","year":"2018","unstructured":"Scholey A (2018) Nutrients for neurocognition in health and disease: measures, methodologies and mechanisms. Proc Nutr Soc 77:73\u201383","journal-title":"Proc Nutr Soc"},{"key":"5248_CR101","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.bbi.2017.02.004","volume":"65","author":"KA Scott","year":"2017","unstructured":"Scott KA, Ida M, Peterson VL et al (2017) Revisiting Metchnikoff: age-related alterations in microbiota-gut-brain axis in the mouse. Brain Behav Immun 65:20\u201332","journal-title":"Brain Behav Immun"},{"issue":"8","key":"5248_CR102","doi-asserted-by":"publisher","first-page":"e1002533","DOI":"10.1371\/journal.pbio.1002533","volume":"14","author":"Ron Sender","year":"2016","unstructured":"Sender R, Fuchs S, Milo R (2016) Revised estimates for the number of human and bacteria cells in the body. PLOS Biology 14(8): e1002533","journal-title":"PLOS Biology"},{"key":"5248_CR103","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.schres.2013.05.018","volume":"148","author":"EG Severance","year":"2013","unstructured":"Severance EG, Gressitt KL, Stallings CR et al (2013) Discordant patterns of bacterial translocation markers and implications for innate immune imbalances in schizophrenia. Schizophr Res 148:130\u2013137","journal-title":"Schizophr Res"},{"key":"5248_CR104","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.schres.2014.06.027","volume":"176","author":"EG Severance","year":"2016","unstructured":"Severance EG, Yolken RH, Eaton WW (2016) Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling. Schizophr Res 176:23\u201335","journal-title":"Schizophr Res"},{"key":"5248_CR105","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1002\/ibd.20903","volume":"15","author":"H Sokol","year":"2009","unstructured":"Sokol H, Seksik P, Furet JP et al (2009) Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis 15:1183\u20131189. \nhttps:\/\/doi.org\/10.1002\/ibd.20903","journal-title":"Inflamm Bowel Dis"},{"key":"5248_CR106","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.bbi.2015.04.003","volume":"48","author":"L Steenbergen","year":"2015","unstructured":"Steenbergen L, Sellaro R, van Hemert S, Bosch JA, Colzato LS (2015) A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain Behav Immun 48:258\u2013264","journal-title":"Brain Behav Immun"},{"key":"5248_CR107","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1113\/jphysiol.2004.063388","volume":"558","author":"N Sudo","year":"2004","unstructured":"Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu XN, Kubo C, Koga Y (2004) Postnatal microbial colonization programs the hypothalamic\u2013pituitary\u2013adrenal system for stress response in mice. J Physiol 558:263\u2013275","journal-title":"J Physiol"},{"issue":"2","key":"5248_CR108","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1039\/C8FO02096E","volume":"10","author":"Ye Sun","year":"2019","unstructured":"Sun Y, Geng W, Pan Y, Wang J, Xiao P, Wang Y (2019) Supplementation with Lactobacillus kefiranofaciens ZW3 from Tibetan Kefir improves depression-like behavior in stressed mice by modulating the gut microbiota. Food Funct. \nhttps:\/\/doi.org\/10.1039\/C8FO02096E","journal-title":"Food & Function"},{"issue":"4","key":"5248_CR109","doi-asserted-by":"publisher","first-page":"288","DOI":"10.4088\/JCP.v63n0404","volume":"63","author":"Trisha Suppes","year":"2002","unstructured":"Suppes T, Dennehy EB, Swann AC et al (2002) Report of the Texas Consensus Conference Panel on medication treatment of bipolar disorder 2000. J Clin Psychiatry 63(4):288\u2013299. \nhttps:\/\/doi.org\/10.4088\/JCP.v63n0404","journal-title":"The Journal of Clinical Psychiatry"},{"key":"5248_CR110","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/ibd.20330","volume":"14","author":"A Swidsinski","year":"2008","unstructured":"Swidsinski A, Loening-Baucke V, Vaneechoutte M, Doerffel Y (2008) Active Crohn\u2019s disease and ulcerative colitis can be specifically diagnosed and monitored based on the biostructure of the fecal flora. Inflamm Bowel Dis 14:147\u2013161. \nhttps:\/\/doi.org\/10.1002\/ibd.20330","journal-title":"Inflamm Bowel Dis"},{"key":"5248_CR111","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1159\/000341309","volume":"82","author":"LG Sylvia","year":"2013","unstructured":"Sylvia LG, Peters AT, Deckersbach T, Nierenberg AA (2013) Nutrient-based therapies for bipolar disorder: a systematic review. Psychother Psychosom 82:10\u201319","journal-title":"Psychother Psychosom"},{"key":"5248_CR112","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1128\/IAI.9.3.591-598.1974","volume":"9","author":"GW Tannock","year":"1974","unstructured":"Tannock GW, Savage DC (1974) Influences of dietary and environmental stress on microbial populations in the murine gastrointestinal tract. Infect Immun 9:591\u2013598","journal-title":"Infect Immun"},{"issue":"33","key":"5248_CR113","doi-asserted-by":"publisher","first-page":"e4617","DOI":"10.1097\/MD.0000000000004617","volume":"95","author":"Ping-Tao Tseng","year":"2016","unstructured":"Tseng P-T, Zeng B-S, Chen Y-W, Wu M-K, Wu C-K, Lin P-Y (2016) A meta-analysis and systematic review of the comorbidity between irritable bowel syndrome and bipolar disorder. Medicine (Baltimore) 95(33):e4617. \nhttps:\/\/doi.org\/10.1097\/MD.0000000000004617","journal-title":"Medicine"},{"key":"5248_CR114","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/nature05414","volume":"444","author":"PJ Turnbaugh","year":"2006","unstructured":"Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444:1027","journal-title":"Nature"},{"key":"5248_CR115","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1002\/ibd.20873","volume":"15","author":"JR Walker","year":"2009","unstructured":"Walker JR, Graff LA, Bernstein CN (2009) Depression and anxiety in inflammatory bowel disease: a review of comorbidity and management. Inflamm Bowel Dis 15:1105\u20131118. \nhttps:\/\/doi.org\/10.1002\/ibd.20873","journal-title":"Inflamm Bowel Dis"},{"key":"5248_CR116","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1053\/j.gastro.2014.09.001","volume":"147","author":"DS Weinberg","year":"2014","unstructured":"Weinberg DS, Smalley W, Heidelbaugh JJ, Sultan S, Association AG (2014) American Gastroenterological Association Institute guideline on the pharmacological management of irritable bowel syndrome. Gastroenterology 147:1146","journal-title":"Gastroenterology"},{"key":"5248_CR117","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1002\/hep.20632","volume":"41","author":"R Wiest","year":"2005","unstructured":"Wiest R, Garcia-Tsao G (2005) Bacterial translocation (BT) in cirrhosis. Hepatology 41:422\u2013433","journal-title":"Hepatology"},{"key":"5248_CR118","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.euroneuro.2006.11.006","volume":"17","author":"J Wozniak","year":"2007","unstructured":"Wozniak J, Biederman J, Mick E, Waxmonsky J, Hantsoo L, Best C, Cluette-Brown JE, Laposata M (2007) Omega-3 fatty acid monotherapy for pediatric bipolar disorder: a prospective open-label trial. Eur Neuropsychopharmacol 17:440\u2013447","journal-title":"Eur Neuropsychopharmacol"},{"key":"5248_CR119","first-page":"13","volume":"66","author":"LN Yatham","year":"2005","unstructured":"Yatham LN (2005) Diagnosis and management of patients with bipolar II disorder. J Clin Psychiatry 66:13\u201317","journal-title":"J Clin Psychiatry"},{"key":"5248_CR120","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1111\/bdi.12416","volume":"18","author":"R Yolken","year":"2016","unstructured":"Yolken R, Adamos M, Katsafanas E et al (2016) Individuals hospitalized with acute mania have increased exposure to antimicrobial medications. Bipolar Disord 18:404\u2013409","journal-title":"Bipolar Disord"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-019-05248-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-019-05248-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-019-05248-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T23:08:41Z","timestamp":1588115321000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-019-05248-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,30]]},"references-count":120,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["5248"],"URL":"https:\/\/doi.org\/10.1007\/s00213-019-05248-6","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,30]]},"assertion":[{"value":"29 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}