{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:55:04Z","timestamp":1788432904761,"version":"build-2803163510"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["03629"],"award-info":[{"award-number":["03629"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000034","name":"Institute of Neurosciences, Mental Health and Addiction","doi-asserted-by":"publisher","award":["388239"],"award-info":[{"award-number":["388239"]}],"id":[{"id":"10.13039\/501100000034","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s00213-019-05373-2","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T06:03:01Z","timestamp":1573452181000},"page":"375-384","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Acute naloxone-precipitated morphine withdrawal elicits nausea-like somatic behaviors in rats in a manner suppressed by N-oleoylglycine"],"prefix":"10.1007","volume":"237","author":[{"given":"Erin M","family":"Rock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha M","family":"Ayoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl L","family":"Limebeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia","family":"Gene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiri L","family":"Wills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieka V","family":"DeVuono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Smoum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Di Marzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aron H","family":"Lichtman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Mechoulam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3494-9754","authenticated-orcid":false,"given":"Linda A","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,11]]},"reference":[{"key":"5373_CR1","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1126\/science.1145590","volume":"26","author":"M Contreras","year":"2007","unstructured":"Contreras M, Ceric F, Torrealba F (2007) Inactivation of the interoceptive insula disrupts drug craving and malaise induced by lithium. Science 26:655\u2013658. https:\/\/doi.org\/10.1126\/science.1145590","journal-title":"Science"},{"key":"5373_CR2","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.neuropharm.2018.03.020","volume":"148","author":"G Donvito","year":"2019","unstructured":"Donvito G, Piscitelli F, Muldoon P, Jackson A, Vitale RM, D\u2019Aniello E et al (2019) N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice. Neuropharmacology 148:320\u2013331. https:\/\/doi.org\/10.1016\/j.neuropharm.2018.03.020","journal-title":"Neuropharmacology"},{"key":"5373_CR3","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/0024-3205(82)90043-1","volume":"31","author":"RM Eisenberg","year":"1982","unstructured":"Eisenberg RM (1982) Further studies on the acute dependence produced by morphine in opiate naive rats. Life Sci 31:1531\u20131540. https:\/\/doi.org\/10.1016\/0024-3205(82)90043-1","journal-title":"Life Sci"},{"key":"5373_CR4","first-page":"44","volume":"201","author":"VF Gellert","year":"1977","unstructured":"Gellert VF, Sparber SB (1977) A comparison of the effects of naloxone upon body weight loss and suppression of fixed-ratio operant behavior in morphine-dependent rats. J Pharmacol ExpTher 201:44\u201354","journal-title":"J Pharmacol ExpTher"},{"key":"5373_CR5","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/0006-8993(78)90568-1","volume":"143","author":"HJ Grill","year":"1978","unstructured":"Grill HJ, Norgren R (1978) The taste reactivity test: 1 Mimetic responses to gustatory stimuli in neurologically normal rats. Brain Res 143:263\u2013279. https:\/\/doi.org\/10.1016\/0006-8993(78)90568-1","journal-title":"Brain Res"},{"key":"5373_CR6","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/0091-3057(90)90421-D","volume":"36","author":"SJ Heishman","year":"1990","unstructured":"Heishman SJ, Stitzer ML, Bigelow GE, Liebson IA (1990) Acute opioid physical dependence in humans: effect of naloxone at 6 and 24 hours postmorphine. Pharmacol Biochem Behav 36:393\u2013399. https:\/\/doi.org\/10.1016\/0091-3057(90)90421-D","journal-title":"Pharmacol Biochem Behav"},{"key":"5373_CR7","unstructured":"Jaffee JH, Martin WR (1990) Opioid analgesics and antagonists. In: Gilman AG, Rall TW, Nies AS, Taylor P (eds) The pharmacological basis of therapeutics (8th ed), Pergamon, New York pp 485-521"},{"key":"5373_CR8","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/0009-9236(95)90152-3","volume":"57","author":"HL June","year":"1995","unstructured":"June HL, Stitzer ML, Cone E (1995) Acute physical dependence: time course and relation to human plasma morphine concentrations. Clin Pharmacol Ther 57:270\u2013280. https:\/\/doi.org\/10.1016\/0009-9236(95)90152-3","journal-title":"Clin Pharmacol Ther"},{"key":"5373_CR9","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.1055\/s-0029-1216356","volume":"42","author":"GF Koob","year":"2009","unstructured":"Koob GF (2009) Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory. Pharmacopsychiatry 42:S32\u2013S41. https:\/\/doi.org\/10.1055\/s-0029-1216356","journal-title":"Pharmacopsychiatry"},{"key":"5373_CR10","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1007\/BF00441954","volume":"98","author":"GF Koob","year":"1989","unstructured":"Koob GF, Wall TL, Bloom FE (1989) Nucleus accumbens as a substrate for the aversive stimulus effects of opiate withdrawal. Psychopharmacology 98:530\u2013534","journal-title":"Psychopharmacology"},{"key":"5373_CR11","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/j.1476-5381.2010.00885.x","volume":"161","author":"CL Limebeer","year":"2010","unstructured":"Limebeer CL, Vemuri VK, Bedard H, Lang ST, Ossenkopp KP, Makriyannis A et al (2010) Inverse agonism of cannabinoid CB1 receptors potentiates LiCl-induced nausea in the conditioned gaping model in rats. Br J Pharmacol 161:336\u2013349. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.00885.x","journal-title":"Br J Pharmacol"},{"key":"5373_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-22218-8","volume-title":"Neurobiological mechanisms of opiate withdrawal","author":"R Maldonado","year":"1996","unstructured":"Maldonado R, Stinus L, Koob GF (1996) Neurobiological mechanisms of opiate withdrawal. R.G. Landes Company, Austin"},{"key":"5373_CR13","first-page":"385","volume":"146","author":"WR Martin","year":"1964","unstructured":"Martin WR, Eades CG (1964) A comparison between acute and chronic physical dependence in the chronic spinal dog. J Pharmacol Exp Ther 146:385\u2013394","journal-title":"J Pharmacol Exp Ther"},{"key":"5373_CR14","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/0091-3057(91)90349-7","volume":"40","author":"BR Martin","year":"1991","unstructured":"Martin BR, Compton DR, Thomas BF, Prescott WR, Little PJ, Razdan RK et al (1991) Behavioral, biochemical, and molecular modeling evaluations of cannabinoid analogs. Pharmacol Biochem Behav 40:471\u2013478. https:\/\/doi.org\/10.1016\/0091-3057(91)90349-7","journal-title":"Pharmacol Biochem Behav"},{"key":"5373_CR15","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/S0091-3057(97)00313-4","volume":"58","author":"RV McDonald","year":"1997","unstructured":"McDonald RV, Parker LA, Siegel S (1997) Conditioned sucrose aversions produced by naloxone-precipitated withdrawal from acutely administered morphine. Pharmacol Biochem Behav 58:1003\u20131008. https:\/\/doi.org\/10.1016\/S0091-3057(97)00313-4","journal-title":"Pharmacol Biochem Behav"},{"key":"5373_CR16","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/0031-9384(92)90368-C","volume":"52","author":"C Meachum","year":"1992","unstructured":"Meachum C, Bernstein IL (1992) Behavioral conditioned responses to contextual andodor stimuli paired with LiCl administration. Physiol Behav 52:895\u2013899. https:\/\/doi.org\/10.1016\/0031-9384(92)90368-C","journal-title":"Physiol Behav"},{"key":"5373_CR17","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.ejphar.2013.09.070","volume":"722","author":"LA Parker","year":"2014","unstructured":"Parker LA (2014) Conditioned flavor avoidance and conditioned gaping: rat models of conditioned nausea. Eur J Pharmacol 722:122\u2013133. https:\/\/doi.org\/10.1016\/j.ejphar.2013.09.070","journal-title":"Eur J Pharmacol"},{"key":"5373_CR18","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0091-3057(01)00724-9","volume":"72","author":"LA Parker","year":"2002","unstructured":"Parker LA, Cyr JA, Santi AN, Burton PD (2002) The aversive properties of acute morphine dependence persist 48 h after a single exposure to morphine: evaluation by taste and place conditioning. Pharmacol Biochem Behav 72:87\u201392. https:\/\/doi.org\/10.1016\/S0091-3057(01)00724-9","journal-title":"Pharmacol Biochem Behav"},{"key":"5373_CR19","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3758\/BF03199972","volume":"12","author":"LA Parker","year":"1984","unstructured":"Parker LA, Hills K, Jensen K (1984) Behavioral CRs elicited by a lithium- or an amphetamine-paired contextual test chamber. Anim Learn Behav 12:307\u2013315. https:\/\/doi.org\/10.3758\/BF03199972","journal-title":"Anim Learn Behav"},{"key":"5373_CR20","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/S0091-3057(98)00104-X","volume":"61","author":"LA Parker","year":"1998","unstructured":"Parker LA, Joshi A (1998) Naloxone-precipitated morphine withdrawal induced place aversions: effect of naloxone at 24 hours postmorphine. Pharmacol Biochem Behav 61:331\u2013333. https:\/\/doi.org\/10.1016\/S0091-3057(98)00104-X","journal-title":"Pharmacol Biochem Behav"},{"key":"5373_CR21","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1007\/s00213-003-1571-2","volume":"171","author":"LA Parker","year":"2004","unstructured":"Parker LA, Kwiatkowska M, Burton P, Mechoulam R (2004) Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew). Psychopharmacology 171:156\u2013161. https:\/\/doi.org\/10.1007\/s00213-003-1571-2","journal-title":"Psychopharmacology"},{"key":"5373_CR22","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s00213-016-4277-y","volume":"232","author":"LA Parker","year":"2014","unstructured":"Parker LA, Niphakis MJ, Downey R, Limebeer CL, Rock EM, Sticht MA, Morris H, Abdullah R, Lichtman AH, Cravatt BF (2014) A new MAGL inhibitor, MJN110, reduces acute and anticipatory nausea in rats and vomiting in Suncus murinus. Psychopharmacology 232:583\u2013593. https:\/\/doi.org\/10.1007\/s00213-016-4277-y","journal-title":"Psychopharmacology"},{"key":"5373_CR23","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/0091-3057(92)90373-n","volume":"41","author":"LA Parker","year":"1992","unstructured":"Parker LA, Rennie M (1992) Naltrexone-induced aversions: Assessment by the placeConditioning, taste reactivity and taste avoidance paradigms. Pharmacol Biochem Behav 41:559\u2013565. https:\/\/doi.org\/10.1016\/0091-3057(92)90373-n","journal-title":"Pharmacol Biochem Behav"},{"key":"5373_CR24","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1007\/s00213-019-05237-9","volume":"236","author":"GN Petrie","year":"2019","unstructured":"Petrie GN, Wills KL, Piscitelli F, Smoum R, Limebeer CL, Rock EM et al (2019) Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague-Dawley rats. Psychopharmacology 236:2623\u20132633. https:\/\/doi.org\/10.1007\/s00213-019-05237-9","journal-title":"Psychopharmacology"},{"key":"5373_CR25","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1124\/jpet.111.181370","volume":"339","author":"D Ramesh","year":"2011","unstructured":"Ramesh D, Ross GR, Schlosburg JE, Owens R, Abdullah R, Kinsey SG et al (2011) Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice. J Pharmacol Exp Ther 339:173\u2013185. https:\/\/doi.org\/10.1124\/jpet.111.181370","journal-title":"J Pharmacol Exp Ther"},{"issue":"20","key":"5373_CR26","doi-asserted-by":"publisher","first-page":"3841","DOI":"10.1007\/s00213-015-4050-7","volume":"232","author":"Erin M. Rock","year":"2015","unstructured":"Rock EM, Limebeer CL, Ward JM, Cohen A, Grove K, Niphakis MJ, Cravatt BF, Parker LA. (2015).Fatty acid amide hydrolase (FAAH) inhibition interferes with acute nausea by a PPAR\u03b1 mechanism and anticipatory nausea by a CB1 receptor mechanism in a double dissociation. Psychopharmacology, 232: 3841-3848. https:\/\/doi.org\/10.1007\/s00213-015-4050-7","journal-title":"Psychopharmacology"},{"key":"5373_CR27","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1111\/bph.13980","volume":"174","author":"EM Rock","year":"2017","unstructured":"Rock EM, Moreno-Sanz G, Limebeer CL, Petrie G, Angelini R, Piomelli D et al (2017) Suppression of acute and anticipatory nausea by peripherally restricted FAAH inhibitor in animal models: role of PPARa and CB1 receptors. Br J Pharmacol 174:3837\u20133847. https:\/\/doi.org\/10.1111\/bph.13980","journal-title":"Br J Pharmacol"},{"key":"5373_CR28","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.neuropharm.2019.05.031","volume":"155","author":"EM Rock","year":"2019","unstructured":"Rock EM, Limebeer CL, Aliasi-Sanai L, Parker LA (2019) The ventral pallidum as a critical region regulating fatty acid amide hydrolase inhibition of nausea-induced conditioned gaping in male Sprague-Dawley rats. Neuropharmacology 155:142\u2013149. https:\/\/doi.org\/10.1016\/j.neuropharm.2019.05.031","journal-title":"Neuropharmacology"},{"key":"5373_CR29","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/sj.npp.1300782","volume":"31","author":"JR Shoblock","year":"2006","unstructured":"Shoblock JR, Maidment NT (2006) Constitutively active mu opioid receptors mediate the enhanced conditioned aversvie effect of naloxone in morphine-dependent mice. Neuropsychopharmacology 31:171\u2013177. https:\/\/doi.org\/10.1038\/sj.npp.1300782","journal-title":"Neuropsychopharmacology"},{"key":"5373_CR30","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.neuropharm.2015.10.039","volume":"102","author":"MA Sticht","year":"2016","unstructured":"Sticht MA, Limebeer CL, Rafla BR, Abdullah RA, Poklis JL, Ho W, Niphakis MJ, Cravatt BF, Sharkey KA, Lichtman AH, Parker LA (2016) Endocannabinoid regulation of nausea is mediated by 2-arachidonolyglycerol (2-AG) in the rat visceral insular cortex. Neuropharmacology 102:92\u2013102. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.10.039","journal-title":"Neuropharmacology"},{"key":"5373_CR31","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/0306-4522(90)90106-E","volume":"37","author":"L Stinus","year":"1990","unstructured":"Stinus L, Le Moal M, Koob GF (1990) Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal. Neuroscience 37:767\u2013773. https:\/\/doi.org\/10.1016\/0306-4522(90)90106-E","journal-title":"Neuroscience"},{"key":"5373_CR32","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.physbeh.2011.10.017","volume":"105","author":"KJ Tuerke","year":"2012","unstructured":"Tuerke KJ, Winters BD, Parker LA (2012) Ondansetron interferes with unconditioned lying-on belly and acquisition of conditioned gaping induced by LiCl as models of nausea-induced behaviors in rats. Physiol Behav 105:856\u2013860. https:\/\/doi.org\/10.1016\/j.physbeh.2011.10.017","journal-title":"Physiol Behav"},{"key":"5373_CR33","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1038\/npp.2015.356","volume":"41","author":"KL Wills","year":"2016","unstructured":"Wills KL, Petrie GN, Millett G, Limebeer CL, Rock EM, Niphakis MJ et al (2016) Double dissociation of monoacylglycerol lipase inhibition and CB1 antagonism in the central amygdala, basolateral amygdala, and the interoceptive insular cortex on the affective properties of acute naloxone-precipitated morphine withdrawal in rats. Neuropsychopharmacology 41:1865\u20131873. https:\/\/doi.org\/10.1038\/npp.2015.356","journal-title":"Neuropsychopharmacology"},{"key":"5373_CR34","doi-asserted-by":"publisher","first-page":"4291","DOI":"10.1007\/s00213-014-3575-5","volume":"231","author":"KL Wills","year":"2014","unstructured":"Wills KL, Vemuri K, Kalmar A, Lee A, Limebeer CL, Makriyannis A et al (2014) CB1 antagonism: interference with affective properties of acute naloxone-precipitated morphine withdrawal in rats. Psychopharmacology 231:4291\u20134300. https:\/\/doi.org\/10.1007\/s00213-014-3575-5","journal-title":"Psychopharmacology"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-019-05373-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-019-05373-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-019-05373-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:10:32Z","timestamp":1604967032000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-019-05373-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,11]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["5373"],"URL":"https:\/\/doi.org\/10.1007\/s00213-019-05373-2","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,11]]},"assertion":[{"value":"17 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}