{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:16:14Z","timestamp":1786979774657,"version":"build-2736575974"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T00:00:00Z","timestamp":1578700800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T00:00:00Z","timestamp":1578700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100009670","name":"National Alliance for Research on Schizophrenia and Depression","doi-asserted-by":"publisher","award":["Independent Investigator Award"],"award-info":[{"award-number":["Independent Investigator Award"]}],"id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006932","name":"International Mental Health Research Organization","doi-asserted-by":"publisher","award":["Rising Star Depression Research Award"],"award-info":[{"award-number":["Rising Star Depression Research Award"]}],"id":[{"id":"10.13039\/100006932","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM07839"],"award-info":[{"award-number":["T32 GM07839"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32 DA07255"],"award-info":[{"award-number":["T32 DA07255"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s00213-019-05397-8","type":"journal-article","created":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T08:02:57Z","timestamp":1578729777000},"page":"627-638","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Ketamine induces immediate and delayed alterations of OCD-like behavior"],"prefix":"10.1007","volume":"237","author":[{"given":"Summer L.","family":"Thompson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda C.","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Iourinets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie C.","family":"Dulawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,11]]},"reference":[{"issue":"5","key":"5397_CR1","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/npp.2011.308","volume":"37","author":"Susanne E Ahmari","year":"2012","unstructured":"Ahmari SE, Risbrough VB, Geyer MA, Simpson HB (2012) Impaired sensorimotor gating in unmedicated adults with obsessive-compulsive disorder. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol 37:1216\u20131223.","journal-title":"Neuropsychopharmacology"},{"key":"5397_CR2","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders (DSM-5\u00ae). American Psychiatric Pub","DOI":"10.1176\/appi.books.9780890425596"},{"issue":"7354","key":"5397_CR3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nature10130","volume":"475","author":"Anita E. Autry","year":"2011","unstructured":"Autry AE, Adachi M, Nosyreva E et al (2011) NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature 475:91\u201395.","journal-title":"Nature"},{"issue":"3","key":"5397_CR4","first-page":"411","volume":"66","author":"M. A. Babyak","year":"2004","unstructured":"Babyak MA (2004) What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models. Psychosom Med 66:411\u2013 421.","journal-title":"Psychosomatic Medicine"},{"key":"5397_CR5","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0006-3223(99)00230-9","volume":"47","author":"RM Berman","year":"2000","unstructured":"Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH (2000) Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 47:351\u2013354","journal-title":"Biol Psychiatry"},{"issue":"11","key":"5397_CR6","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.biopsych.2012.05.028","volume":"72","author":"Michael H. Bloch","year":"2012","unstructured":"Bloch MH, Wasylink S, Landeros-Weisenberger A et al (2012) Effects of ketamine in treatment-refractory obsessive-compulsive disorder. Biol Psychiatry 72:964\u2013970.","journal-title":"Biological Psychiatry"},{"issue":"1-3","key":"5397_CR7","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.schres.2012.01.024","volume":"136","author":"Ming-Huan Chan","year":"2012","unstructured":"Chan M-H, Chiu P-H, Lin C-Y, Chen H-H (2012) Inhibition of glycogen synthase kinase-3 attenuates psychotomimetic effects of ketamine. Schizophr Res 136:96\u2013103.","journal-title":"Schizophrenia Research"},{"issue":"1","key":"5397_CR8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00213-008-1103-1","volume":"198","author":"Ming-Huan Chan","year":"2008","unstructured":"Chan M-H, Chiu P-H, Sou J-H, Chen H-H (2008) Attenuation of ketamine-evoked behavioral responses by mGluR5 positive modulators in mice. Psychopharmacology 198:141\u2013148.","journal-title":"Psychopharmacology"},{"key":"5397_CR9","first-page":"104","volume":"31","author":"HK Chaturvedi","year":"1999","unstructured":"Chaturvedi HK, Dinesh C, Bapna JS (1999) Effect of NMDA receptor antagonists in forced swimming test and its modification by antidepressants. Indian J Pharm 31:104","journal-title":"Indian J Pharm"},{"key":"5397_CR10","doi-asserted-by":"crossref","unstructured":"Choi I-S, Cho J-H, An C-H et al (2012) 5-HT(1B) receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons. Br J Pharmacol 167:356\u2013367.","DOI":"10.1111\/j.1476-5381.2012.01964.x"},{"issue":"11","key":"5397_CR11","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.biopsych.2011.11.006","volume":"71","author":"Golam M.I. Chowdhury","year":"2012","unstructured":"Chowdhury GMI, Behar KL, Cho W, Thomas MA, Rothman DL, Sanacora G (2012) 1H-[13C]-Nuclear magnetic resonance spectroscopy measures of ketamine\u2019s effect on amino acid neurotransmitter metabolism. Biol Psychiatry 71:1022\u20131025.","journal-title":"Biological Psychiatry"},{"issue":"1","key":"5397_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3758\/s13415-018-00653-4","volume":"19","author":"Geoffrey de Brouwer","year":"2018","unstructured":"de Brouwer G, Fick A, Harvey BH, Wolmarans DW (2018) A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: mapping the way forward. Cogn Affect Behav Neurosci 19:1\u201339.","journal-title":"Cognitive, Affective, & Behavioral Neuroscience"},{"key":"5397_CR13","doi-asserted-by":"crossref","unstructured":"de Oliveira L, Spiazzi CM, Bortolin T et al (2009) Different sub-anesthetic doses of ketamine increase oxidative stress in the brain of rats. Prog Neuro- Psychopharmacol Biol Psychiatry 33:1003\u20131008.","DOI":"10.1016\/j.pnpbp.2009.05.010"},{"key":"5397_CR14","doi-asserted-by":"crossref","unstructured":"Dold M, Aigner M, Lanzenberger R, Kasper S (2015) Antipsychotic augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: an update meta-analysis of double-blind, randomized, placebo-controlled trials. Int J Neuropsychopharmacol Off Sci J Coll Int Neuropsychopharmacol CINP.","DOI":"10.1093\/ijnp\/pyv047"},{"issue":"7","key":"5397_CR15","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s00213-013-3315-2","volume":"231","author":"T. N. Douma","year":"2013","unstructured":"Douma TN, Millan MJ, Boulay D, Griebel G, Verdouw PM, Westphal KG, Olivier B, Groenink L (2014) CRF1 receptor antagonists do not reverse pharmacological disruption of prepulse inhibition in rodents. Psychopharmacology 231:1289\u20131303.","journal-title":"Psychopharmacology"},{"key":"5397_CR16","doi-asserted-by":"crossref","unstructured":"du Jardin KG, Liebenberg N, Cajina M, M\u00fcller HK, Elfving B, Sanchez C, Wegener G (2017) S-Ketamine mediates its acute and sustained antidepressant-like activity through a 5-HT1B receptor dependent mechanism in a genetic rat model of depression. Front Pharmacol 8:978.","DOI":"10.3389\/fphar.2017.00978"},{"issue":"6","key":"5397_CR17","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1001\/jamapsychiatry.2014.62","volume":"71","author":"Adriana Feder","year":"2014","unstructured":"Feder A, Parides MK, Murrough JW, Perez AM, Morgan JE, Saxena S, Kirkwood K, aan het Rot M, Lapidus KA, Wan LB, Iosifescu D, Charney DS (2014) Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. JAMA Psychiatry 71:681\u2013688.","journal-title":"JAMA Psychiatry"},{"issue":"08","key":"5397_CR18","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1017\/S1461145711001829","volume":"15","author":"Naomi A. Fineberg","year":"2012","unstructured":"Fineberg NA, Brown A, Reghunandanan S, Pampaloni I (2012) Evidence-based pharmacotherapy of obsessive-compulsive disorder. Int J Neuropsychopharmacol Off Sci J Coll Int Neuropsychopharmacol CINP 15:1173\u20131191.","journal-title":"The International Journal of Neuropsychopharmacology"},{"key":"5397_CR19","unstructured":"Fisher RA (1934) IV: Tests of goodness of fit, independence and homogeneity; WITH TABLE OF X2. In: Statistical Methods for Research Workers, 5th edn. Oliver and Boyd, pp 103\u2013105"},{"key":"5397_CR20","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jpsychires.2018.02.006","volume":"100","author":"Daiane B. Fraga","year":"2018","unstructured":"Fraga DB, Olescowicz G, Moretti M, Siteneski A, Tavares MK, Azevedo D, Colla ARS, Rodrigues ALS (2018) Anxiolytic effects of ascorbic acid and ketamine in mice. J Psychiatr Res 100:16\u201323.","journal-title":"Journal of Psychiatric Research"},{"key":"5397_CR21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neuroscience.2015.01.008","volume":"290","author":"A. Franceschelli","year":"2015","unstructured":"Franceschelli A, Sens J, Herchick S et al (2015) Sex differences in the rapid and the sustained antidepressant-like effects of ketamine in stress-na\u00efve and \u201cdepressed\u201d mice exposed to chronic mild stress. Neuroscience 290:49\u201360.","journal-title":"Neuroscience"},{"issue":"3","key":"5397_CR22","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.drudis.2016.01.016","volume":"21","author":"Danielle M. Gerhard","year":"2016","unstructured":"Gerhard DM, Wohleb ES, Duman RS (2016) Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity. Drug Discov Today 21:454\u2013464.","journal-title":"Drug Discovery Today"},{"issue":"4","key":"5397_CR23","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1177\/0269881109104845","volume":"24","author":"M. Ghasemi","year":"2009","unstructured":"Ghasemi M, Raza M, Dehpour AR (2010) NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test. J Psychopharmacol Oxf Engl 24:585\u2013594.","journal-title":"Journal of Psychopharmacology"},{"issue":"23","key":"5397_CR24","doi-asserted-by":"crossref","first-page":"8649","DOI":"10.1073\/pnas.1323920111","volume":"111","author":"E. S. Gideons","year":"2014","unstructured":"Gideons ES, Kavalali ET, Monteggia LM (2014) Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses. Proc Natl Acad Sci U S A 111:8649\u20138654.","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"5397_CR25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1001\/archpsyc.1995.03950130053006","volume":"52","author":"JH Greist","year":"1995","unstructured":"Greist JH, Jefferson JW, Kobak KA, Katzelnick DJ, Serlin RC (1995) Efficacy and tolerability of serotonin transport inhibitors in obsessive-compulsive disorder. A meta-analysis. Arch Gen Psychiatry 52:53\u201360","journal-title":"Arch Gen Psychiatry"},{"issue":"3","key":"5397_CR26","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000079970","volume":"50","author":"Ruth Gross-Isseroff","year":"2004","unstructured":"Gross-Isseroff R, Cohen R, Sasson Y, Voet H, Zohar J (2004) Serotonergic dissection of obsessive compulsive symptoms: a challenge study with mchlorophenylpiperazine and sumatriptan. Neuropsychobiology 50:200\u2013205.","journal-title":"Neuropsychobiology"},{"key":"5397_CR27","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neuropharm.2017.09.013","volume":"126","author":"Ji-Dong Guo","year":"2017","unstructured":"Guo J-D, O\u2019Flaherty BM, Rainnie DG (2017) Serotonin gating of cortical and thalamic glutamate inputs onto principal neurons of the basolateral amygdala. Neuropharmacology 126:224\u2013232.","journal-title":"Neuropharmacology"},{"issue":"1","key":"5397_CR28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2202-7-25","volume":"7","author":"Tamaki Hayase","year":"2006","unstructured":"Hayase T, Yamamoto Y, Yamamoto K (2006) Behavioral effects of ketamine and toxic interactions with psychostimulants. BMC Neurosci 7:25.","journal-title":"BMC Neuroscience"},{"key":"5397_CR29","unstructured":"Ho EV, Thompson SL, Katzka WR, Sharifi MF, Knowles JA, Dulawa SC (2016) Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive 10.1007\/s00213-019-05397-8 Ho EV, Thompson SL, Katzka WR, Sharifi MF, Knowles JA, Dulawa SC (2016) Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation. Psychopharmacology 233:57\u201370."},{"issue":"11","key":"5397_CR30","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1007\/s00213-016-4256-3","volume":"233","author":"Kristina Holubova","year":"2016","unstructured":"Holubova K, Kleteckova L, Skurlova M, Ricny J, Stuchlik A, Vales K (2016) Rapamycin blocks the antidepressant effect of ketamine in task-dependent manner. Psychopharmacology 233:2077\u20132097.","journal-title":"Psychopharmacology"},{"key":"5397_CR31","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.pnpbp.2013.04.006","volume":"45","author":"Yue Hou","year":"2013","unstructured":"Hou Y, Zhang H, Xie G, Cao X, Zhao Y, Liu Y, Mao Z, Yang J, Wu C (2013) Neuronal injury, but not microglia activation, is associated with ketamine-induced experimental schizophrenic model in mice. Prog Neuro-Psychopharmacol Biol Psychiatry 45:107\u2013116.","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"issue":"3","key":"5397_CR32","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.brainresbull.2006.01.010","volume":"69","author":"Gabor Imre","year":"2006","unstructured":"Imre G, Fokkema DS, Boer JAD, Ter Horst GJ (2006) Dose\u2013response characteristics of ketamine effect on locomotion, cognitive function and central neuronal activity. Brain Res Bull 69:338\u2013345.","journal-title":"Brain Research Bulletin"},{"issue":"05","key":"5397_CR33","doi-asserted-by":"crossref","first-page":"e605","DOI":"10.4088\/JCP.14r09758","volume":"77","author":"Yasmin Issari","year":"2016","unstructured":"Issaria Y, Jakubovski E, Bartley CA et al (2016) Early onset of response with selective serotonin reuptake inhibitors in obsessive-compulsive disorder: a metaanalysis. J Clin Psychiatry 77:e605\u2013e611.","journal-title":"The Journal of Clinical Psychiatry"},{"key":"5397_CR34","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1191\/1471082X03st053oa","volume":"3","author":"R Kieschnick","year":"2003","unstructured":"Kieschnick R, McCullough BD (2003) Regression analysis of variates observed on (0, 1): percentages, proportions and fractions. Stat Model Int J 3:193\u2013213. https:\/\/doi.org\/10.1191\/1471082X03st053oa","journal-title":"Stat Model Int J"},{"key":"5397_CR35","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0924-977X(01)00082-7","volume":"11","author":"LM Koran","year":"2001","unstructured":"Koran LM, Pallanti S, Quercioli L (2001) Sumatriptan, 5-HT(1D) receptors and obsessive-compulsive disorder. Eur Neuropsychopharmacol J Eur Coll Neuropsychopharmacol 11:169\u2013172","journal-title":"Eur Neuropsychopharmacol J Eur Coll Neuropsychopharmacol"},{"issue":"8","key":"5397_CR36","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.biopsych.2010.12.015","volume":"69","author":"Nanxin Li","year":"2011","unstructured":"Li N, Liu R-J, Dwyer JM, Banasr M, Lee B, Son H, Li XY, Aghajanian G, Duman RS (2011) Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatry 69:754\u2013761.","journal-title":"Biological Psychiatry"},{"issue":"27","key":"5397_CR37","doi-asserted-by":"crossref","first-page":"7815","DOI":"10.1002\/anie.201503312","volume":"54","author":"Xue Li","year":"2015","unstructured":"Li X, Martinez-Lozano Sinues P, Dallmann R et al (2015) Drug pharmacokinetics determined by real-time analysis of mouse breath. Angew Chem Int Ed 54:7815\u20137818.","journal-title":"Angewandte Chemie International Edition"},{"key":"5397_CR38","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0306-4522(02)00652-8","volume":"117","author":"DS Lorrain","year":"2003","unstructured":"Lorrain DS, Baccei CS, Bristow LJ, Anderson JJ, Varney MA (2003) Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268. Neuroscience 117:697\u2013706","journal-title":"Neuroscience"},{"key":"5397_CR39","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.pnpbp.2018.05.019","volume":"86","author":"Cheng Wei Lu","year":"2018","unstructured":"Lu CW, Lin TY, Huang SK, Wang SJ (2018) 5-HT1B receptor agonist CGS12066 presynaptically inhibits glutamate release in rat hippocampus. Prog Neuro- Psychopharmacol Biol Psychiatry 86:122\u2013130.","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"key":"5397_CR40","doi-asserted-by":"crossref","unstructured":"Maeng S, Zarate CA, Du J et al (2008) Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole- 4-propionic acid receptors. Biol Psychiatry 63:349\u2013352.","DOI":"10.1016\/j.biopsych.2007.05.028"},{"issue":"8","key":"5397_CR41","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1038\/npp.2017.19","volume":"42","author":"Josephine C McGowan","year":"2017","unstructured":"McGowan JC, LaGamma CT, Lim SC, Tsitsiklis M, Neria Y, Brachman RA, Denny CA (2017) Prophylactic ketamine attenuates learned fear. Neuropsychopharmacology 42:1577\u20131589.","journal-title":"Neuropsychopharmacology"},{"key":"5397_CR42","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1523\/JNEUROSCI.17-08-02921.1997","volume":"17","author":"B Moghaddam","year":"1997","unstructured":"Moghaddam B, Adams B, Verma A, Daly D (1997) Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci 17:2921\u20132927","journal-title":"J Neurosci"},{"key":"5397_CR43","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/00004850-199206001-00003","volume":"7","author":"S. A. Montgomery","year":"1992","unstructured":"Montgomery SA, Manceaux A (1992) Fluvoxamine in the treatment of obsessive compulsive disorder. Int Clin Psychopharmacol:5\u201310","journal-title":"International Clinical Psychopharmacology"},{"key":"5397_CR44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0014-2999(87)90253-6","volume":"139","author":"C Oberlander","year":"1987","unstructured":"Oberlander C, Demassey Y, Verdu A, van de Velde D, Bardelay C (1987) Tolerance to the serotonin 5-HT1 agonist RU 24969 and effects on dopaminergic behaviour. Eur J Pharmacol 139:205\u2013214","journal-title":"Eur J Pharmacol"},{"key":"5397_CR45","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuropharm.2018.08.017","volume":"141","author":"Andrea Ossato","year":"2018","unstructured":"Ossato A, Bilel S, Gregori A, Talarico A, Trapella C, Gaudio RM, de-Giorgio F, Tagliaro F, Neri M, Fattore L, Marti M (2018) Neurological, sensorimotor and cardiorespiratory alterations induced by methoxetamine, ketamine and phencyclidine in mice. Neuropharmacology 141:167\u2013180.","journal-title":"Neuropharmacology"},{"key":"5397_CR46","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/BF02244547","volume":"104","author":"MP Paulus","year":"1991","unstructured":"Paulus MP, Geyer MA (1991a) A temporal and spatial scaling hypothesis for the behavioral effects of psychostimulants. Psychopharmacology 104:6\u201316","journal-title":"Psychopharmacology"},{"issue":"6","key":"5397_CR47","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/0278-5846(91)90018-V","volume":"15","author":"Martin P. Paulus","year":"1991","unstructured":"Paulus MP, Geyer MA (1991b) A scaling approach to find order parameters quantifying the effects of dopaminergic agents on unconditioned motor activity in rats. Prog Neuro-Psychopharmacol Biol Psychiatry 15:903\u2013919.","journal-title":"Progress in Neuro-Psychopharmacology and Biological Psychiatry"},{"issue":"4","key":"5397_CR48","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s12640-017-9759-0","volume":"32","author":"Piotr Popik","year":"2017","unstructured":"Popik P, Ho\u0142uj M, Kos T, Nowak G, Librowski T, Sa\u0142at K (2017) Comparison of the psychopharmacological effects of tiletamine and ketamine in rodents. Neurotox Res 32:544\u2013554.","journal-title":"Neurotoxicity Research"},{"issue":"3","key":"5397_CR49","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00213-008-1158-z","volume":"198","author":"Piotr Popik","year":"2008","unstructured":"Popik P, Kos T, Sowa-Ku\u0107ma M, Nowak G (2008) Lack of persistent effects of ketamine in rodent models of depression. Psychopharmacology 198:421\u2013430.","journal-title":"Psychopharmacology"},{"key":"5397_CR50","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pbb.2016.12.014","volume":"153","author":"Kennett D. Radford","year":"2017","unstructured":"Radford KD, Park TY, Lee BH et al (2017) Dose-response characteristics of intravenous ketamine on dissociative stereotypy, locomotion, sensorimotor gating, and nociception in male Sprague-Dawley rats. Pharmacol Biochem Behav 153:130\u2013140.","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"3","key":"5397_CR51","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/sj.npp.1301057","volume":"32","author":"Florence Razoux","year":"2006","unstructured":"Razoux F, Garcia R, L\u00e9na I (2007) Ketamine, at a dose that disrupts motor behavior and latent inhibition, enhances prefrontal cortex synaptic efficacy and glutamate release in the nucleus accumbens. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol 32:719\u2013727.","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"5397_CR52","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/FBP.0000000000000266","volume":"28","author":"Louise K. Refsgaard","year":"2017","unstructured":"Refsgaard LK, Pickering DS, Andreasen JT (2017) Investigation of antidepressant-like and anxiolytic-like actions and cognitive and motor side effects of four Nmethyl-D-aspartate receptor antagonists in mice. Behav Pharmacol 28:37\u201347.","journal-title":"Behavioural Pharmacology"},{"issue":"12","key":"5397_CR53","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1038\/npp.2013.150","volume":"38","author":"Carolyn I Rodriguez","year":"2013","unstructured":"Rodriguez CI, Kegeles LS, Levinson A, Feng T, Marcus SM, Vermes D, Flood P, Simpson HB (2013) Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: proof-of-concept. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol 38:2475\u20132483. 10.1007\/s00213-019-05397-8 obsessive-compulsive disorder: proof-of-concept. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol 38:2475\u20132483.","journal-title":"Neuropsychopharmacology"},{"issue":"03","key":"5397_CR54","doi-asserted-by":"crossref","first-page":"408","DOI":"10.4088\/JCP.15l10138","volume":"77","author":"Carolyn I. Rodriguez","year":"2016","unstructured":"Rodriguez CI, Wheaton M, Zwerling J et al (2016) Can exposure-based CBT extend the effects of intravenous ketamine in obsessive-compulsive disorder? an open-label trial. J Clin Psychiatry 77:408\u2013409.","journal-title":"The Journal of Clinical Psychiatry"},{"issue":"1","key":"5397_CR55","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/mp.2008.94","volume":"15","author":"A M Ruscio","year":"2008","unstructured":"Ruscio AM, Stein DJ, Chiu WT, Kessler RC (2010) The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry 15:53\u201363.","journal-title":"Molecular Psychiatry"},{"key":"5397_CR56","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.neuropharm.2015.07.037","volume":"99","author":"Kinga Sa\u0142at","year":"2015","unstructured":"Sa\u0142at K, Siwek A, Starowicz G et al (2015) Antidepressant-like effects of ketamine, norketamine and dehydronorketamine in forced swim test: Role of activity at NMDA receptor. Neuropharmacology 99:301\u2013307.","journal-title":"Neuropharmacology"},{"issue":"5","key":"5397_CR57","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.biopsych.2008.09.026","volume":"65","author":"Nancy A. Shanahan","year":"2009","unstructured":"Shanahan NA, Holick Pierz KA, Masten VL, Waeber C, Ansorge M, Gingrich JA, Geyer MA, Hen R, Dulawa SC (2009) Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice. Biol Psychiatry 65:401\u2013408.","journal-title":"Biological Psychiatry"},{"issue":"11","key":"5397_CR58","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.biopsych.2011.07.032","volume":"70","author":"Nancy A. Shanahan","year":"2011","unstructured":"Shanahan NA, Velez LP, Masten VL, Dulawa SC (2011) Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice. Biol Psychiatry 70:1039\u20131048.","journal-title":"Biological Psychiatry"},{"issue":"1","key":"5397_CR59","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1037\/1082-989X.11.1.54","volume":"11","author":"Michael Smithson","year":"2006","unstructured":"Smithson M, Verkuilen J (2006) A better lemon squeezer? Maximum-likelihood regression with beta-distributed dependent variables. Psychol Methods 11:54\u201371.","journal-title":"Psychological Methods"},{"issue":"2","key":"5397_CR60","first-page":"ENEURO.0116-15.","volume":"3","author":"Amelie Soumier","year":"2016","unstructured":"Soumier A, Carter RM, Schoenfeld TJ, Cameron HA (2016) New hippocampal neurons mature rapidly in response to ketamine but are not required for its acute antidepressant effects on neophagia in rats. eNeuro 3:.","journal-title":"eneuro"},{"key":"5397_CR61","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0278-5846(99)00051-2","volume":"23","author":"DJ Stein","year":"1999","unstructured":"Stein DJ, Van Heerden B, Wessels CJ et al (1999) Single photon emission computed tomography of the brain with Tc-99 m HMPAO during sumatriptan challenge in obsessive-compulsive disorder: investigating the functional role of the serotonin auto-receptor. Prog Neuro-Psychopharmacol Biol Psychiatry 23:1079\u20131099","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"3","key":"5397_CR62","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.psc.2014.05.004","volume":"37","author":"Emily R. Stern","year":"2014","unstructured":"Stern ER, Taylor SF (2014) Cognitive neuroscience of obsessive-compulsive disorder. Psychiatr Clin North Am 37:337\u2013352.","journal-title":"Psychiatric Clinics of North America"},{"key":"5397_CR63","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.neuroscience.2018.11.053","volume":"398","author":"Connor Thelen","year":"2019","unstructured":"Thelen C, Flaherty E, Saurine J, Sens J, Mohamed S, Pitychoutis PM (2019) Sex differences in the temporal neuromolecular and synaptogenic effects of the rapidacting antidepressant drug ketamine in the mouse brain. Neuroscience 398:182\u2013192.","journal-title":"Neuroscience"},{"issue":"2","key":"5397_CR64","doi-asserted-by":"crossref","first-page":"e0211239","DOI":"10.1371\/journal.pone.0211239","volume":"14","author":"Summer L. Thompson","year":"2019","unstructured":"Thompson SL, Dulawa SC (2019) Dissecting the roles of \u03b2-arrestin2 and GSK-3 signaling in 5-HT1BR-mediated perseverative behavior and prepulse inhibition deficits in mice. PLoS One 14:e0211239.","journal-title":"PLOS ONE"},{"key":"5397_CR65","unstructured":"Thompson SL, Dulawa SC (2017) Pharmacological and behavioral rodent models of OCD. In: Pittenger C (ed) Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment. Oxford University Press, pp 385\u2013400"},{"key":"5397_CR66","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neuropharm.2018.10.039","volume":"144","author":"Cristina Luz Tosta","year":"2019","unstructured":"Tosta CL, Silote GP, Fracalossi MP, Sartim AG, Andreatini R, Joca SRL, Beijamini V (2019) S-ketamine reduces marble burying behaviour: involvement of ventromedial orbitofrontal cortex and AMPA receptors. Neuropharmacology 144:233\u2013243.","journal-title":"Neuropharmacology"},{"key":"5397_CR67","doi-asserted-by":"crossref","unstructured":"Veale D, Miles S, Smallcombe N, Ghezai H, Goldacre B, Hodsoll J (2014) Atypical antipsychotic augmentation in SSRI treatment refractory obsessivecompulsive disorder: a systematic review and meta-analysis. BMC Psychiatry 14:317.","DOI":"10.1186\/s12888-014-0317-5"},{"issue":"1-2","key":"5397_CR68","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0006-8993(91)90178-X","volume":"554","author":"S.Y. Wu","year":"1991","unstructured":"Wu SY, Wang MY, Dun NJ (1991) Serotonin via presynaptic 5-HT1 receptors attenuates synaptic transmission to immature rat motoneurons in vitro. Brain Res 554:111\u2013121.","journal-title":"Brain Research"},{"issue":"1","key":"5397_CR69","doi-asserted-by":"crossref","first-page":"e342","DOI":"10.1038\/tp.2013.112","volume":"4","author":"H Yamanaka","year":"2014","unstructured":"Yamanaka H, Yokoyama C, Mizuma H, Kurai S, Finnema SJ, Halldin C, Doi H, Onoe H (2014) A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques. Transl Psychiatry 4:e342.","journal-title":"Translational Psychiatry"},{"key":"5397_CR70","doi-asserted-by":"crossref","unstructured":"Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI, Alkondon M, Yuan P, Pribut HJ, Singh NS, Dossou KS, Fang Y, Huang XP, Mayo CL, Wainer IW, Albuquerque EX, Thompson SM, Thomas CJ, Zarate CA Jr, Gould TD (2016) NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature 533:481\u2013486.","DOI":"10.1038\/nature17998"},{"issue":"1","key":"5397_CR71","first-page":"ENEURO.0285-16.","volume":"4","author":"Panos Zanos","year":"2017","unstructured":"Zanos P, Nelson ME, Highland JN, et al (2017) A negative allosteric modulator for \u03b15 subunit-containing GABA receptors exerts a rapid and persistent antidepressant-like action without the side effects of the NMDA receptor antagonist ketamine in mice. eNeuro 4:.","journal-title":"eneuro"},{"issue":"1","key":"5397_CR72","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1124\/jpet.115.225664","volume":"355","author":"Panos Zanos","year":"2015","unstructured":"Zanos P, Piantadosi SC, Wu H-Q et al (2015) The prodrug 4-chlorokynurenine causes ketamine-like antidepressant effects, but not side effects, by NMDA\/GlycineB-Site Inhibition. J Pharmacol Exp Ther 355:76\u201385.","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"8","key":"5397_CR73","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1001\/archpsyc.63.8.856","volume":"63","author":"Carlos A. Zarate","year":"2006","unstructured":"Zarate CA, Singh JB, Carlson PJ et al (2006) A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 63:856\u2013864.","journal-title":"Archives of General Psychiatry"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-019-05397-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-019-05397-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-019-05397-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T20:27:55Z","timestamp":1610224075000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-019-05397-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,11]]},"references-count":73,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["5397"],"URL":"https:\/\/doi.org\/10.1007\/s00213-019-05397-8","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,11]]},"assertion":[{"value":"31 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}