{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:38:47Z","timestamp":1790393927825,"version":"4.1.0"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s00213-019-05443-5","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T01:02:45Z","timestamp":1578358965000},"page":"1131-1145","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Catecholaminergic and opioidergic system mediated effects of reboxetine on diabetic neuropathic pain"],"prefix":"10.1007","volume":"237","author":[{"given":"Nazl\u0131","family":"Turan Y\u00fccel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcr Devrim","family":"Can","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dcmide","family":"Demir \u00d6zkay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,7]]},"reference":[{"issue":"9","key":"5443_CR1","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1007\/s11892-014-0528-7","volume":"14","author":"L Ang","year":"2014","unstructured":"Ang L, Jaiswal M, Martin C, Pop-Busui R (2014) Glucose control and diabetic neuropathy: lessons from recent large clinical trials. Curr Diab Rep 14(9):528","journal-title":"Curr Diab Rep"},{"issue":"9","key":"5443_CR2","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1111\/j.1468-1331.2010.02999.x","volume":"17","author":"N Attal","year":"2010","unstructured":"Attal N, Cruccu G, Baron R, Haanp\u00e4\u00e4 M, Hansson P, Jensen TS, Nurmikko T, European Federation of Neurological Societies (2010) EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision. Eur J Neurol 17(9):1113\u20131e88","journal-title":"Eur J Neurol"},{"issue":"6","key":"5443_CR3","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/fcp.12224","volume":"30","author":"TH Ayd\u0131n","year":"2016","unstructured":"Ayd\u0131n TH, Can \u00d6D, Demir \u00d6zkay \u00dc, Turan N (2016) Effect of subacute agomelatine treatment on painful diabetic neuropathy: involvement of catecholaminergic mechanisms. Fundam Clin Pharmacol 30(6):549\u2013567","journal-title":"Fundam Clin Pharmacol"},{"key":"5443_CR4","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.nurt.2009.07.009","volume":"6","author":"K Bannister","year":"2009","unstructured":"Bannister K, Bee LA, Dickenson AH (2009) Preclinical and early clinical investigations related to monoaminergic pain modulation. Neurotherapeutics 6:703\u2013712","journal-title":"Neurotherapeutics"},{"issue":"8","key":"5443_CR5","doi-asserted-by":"publisher","first-page":"E2072","DOI":"10.3390\/molecules23082072","volume":"23","author":"MB Barbaros","year":"2018","unstructured":"Barbaros MB, Can \u00d6D, \u00dc\u00e7el U\u0130, Turan Y\u00fccel N, Demir \u00d6zkay \u00dc (2018) Antihyperalgesic activity of atomoxetine on diabetes-induced neuropathic pain: contribution of noradrenergic and dopaminergic systems. Molecules 23(8):E2072","journal-title":"Molecules"},{"issue":"2","key":"5443_CR6","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.1526-4637.2006.00179.x","volume":"8","author":"AM Barrett","year":"2007","unstructured":"Barrett AM, Lucero MA, Le T, Robinson RL, Dworkin RH, Chappell AS (2007) Epidemiology, public health burden, and treatment of diabetic peripheral neuropathic pain: a review. Pain Med 8(2):50\u201362","journal-title":"Pain Med"},{"issue":"3","key":"5443_CR7","doi-asserted-by":"publisher","first-page":"182","DOI":"10.2174\/157488909789104794","volume":"4","author":"M Barrot","year":"2009","unstructured":"Barrot M, Yalcin I, Choucair-Jaafar N, Benbouzid M, Freund-Mercier MJ (2009) From antidepressant drugs to beta-mimetics: preclinical insights on potential new treatments for neuropathic pain. Recent Pat CNS Drug Discov 4(3):182\u2013189","journal-title":"Recent Pat CNS Drug Discov"},{"issue":"3","key":"5443_CR8","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/S0893-133X(00)00112-3","volume":"23","author":"JC B\u00e9\u00efque","year":"2000","unstructured":"B\u00e9\u00efque JC, Blier P, de Montigny C, Debonnel G (2000) Potentiation by (\u2212)Pindolol of the activation of postsynaptic 5-HT(1A) receptors induced by venlafaxine. Neuropsychopharmacology 23(3):294\u2013306","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"5443_CR9","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.ejpain.2008.01.010","volume":"12","author":"M Benbouzid","year":"2008","unstructured":"Benbouzid M, Choucair-Jaafar N, Yalcin I, Waltisperger E, Muller A, Freund-Mercier MJ, Barrot M (2008a) Chronic but not acute, tricyclic antidepressant treatment alleviates neuropathic allodynia after sciatic nerve cuffing in mice. Eur J Pain 12(8):1008\u20131017","journal-title":"Eur J Pain"},{"issue":"6","key":"5443_CR10","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.biopsych.2007.06.016","volume":"63","author":"M Benbouzid","year":"2008","unstructured":"Benbouzid M, Gav\u00e9riaux-Ruff C, Yalcin I, Waltisperger E, Tessier LH, Muller A, Kieffer BL, Freund-Mercier MJ, Barrot M (2008b) Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia. Biol Psychiatry 63(6):633\u2013636","journal-title":"Biol Psychiatry"},{"issue":"7","key":"5443_CR11","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.ejpain.2009.11.014","volume":"14","author":"Y Bohren","year":"2010","unstructured":"Bohren Y, Karavelic D, Tessier LH, Yalcin I, Gav\u00e9riaux-Ruff C, Kieffer BL, Freund-Mercier MJ, Barrot M (2010) Mu-opioid receptors are not necessary for nortriptyline treatment of neuropathic allodynia. Eur J Pain 14(7):700\u2013704","journal-title":"Eur J Pain"},{"key":"5443_CR12","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.nbd.2013.08.012","volume":"60","author":"Y Bohren","year":"2013","unstructured":"Bohren Y, Tessier LH, Megat S, Petitjean H, Hugel S, Daniel D, Kremer M, Fournel S, Hein L, Schlichter R, Freund-Mercier MJ, Yalcin I, Barrot M (2013) Antidepressants suppress neuropathic pain by a peripheral \u03b22-adrenoceptor mediated anti-TNF\u03b1 mechanism. Neurobiol Dis 60:39\u201350","journal-title":"Neurobiol Dis"},{"key":"5443_CR13","doi-asserted-by":"publisher","first-page":"h5842","DOI":"10.1136\/bmj.h5842","volume":"351","author":"R Braithwaite","year":"2015","unstructured":"Braithwaite R (2015) Reboxetine has no antidepressant effect at all. BMJ 351:h5842","journal-title":"BMJ"},{"key":"5443_CR14","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.neulet.2015.12.059","volume":"614","author":"S Castany","year":"2016","unstructured":"Castany S, Carcol\u00e9 M, Le\u00e1nez S, Pol O (2016) The antinociceptive effects of a \u03b4-opioid receptor agonist in mice with painful diabetic neuropathy: involvement of heme oxygenase 1. Neurosci Lett 614:49\u201354","journal-title":"Neurosci Lett"},{"issue":"1\u20132","key":"5443_CR15","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1159\/000345035","volume":"91","author":"K Cegielska-Perun","year":"2013","unstructured":"Cegielska-Perun K, Bujalska-Zadro\u017cny M, Tatarkiewicz J, G\u0105si\u0144ska E, Makulska-Nowak HE (2013) Venlafaxine and neuropathic pain. Pharmacology 91(1\u20132):69\u201376","journal-title":"Pharmacology"},{"issue":"2","key":"5443_CR16","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.pharep.2013.09.003","volume":"66","author":"K Cegielski-Perun","year":"2014","unstructured":"Cegielski-Perun K, Bujalska-Zadro\u017cny M, Gasi\u0144ska E, Makulska-Nowak HE (2014) Enhancement of antinociceptive effect of morphine by antidepressants in diabetic neuropathic pain model. Pharmacol Rep 66(2):228\u2013234","journal-title":"Pharmacol Rep"},{"issue":"5","key":"5443_CR17","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1111\/ejn.14093","volume":"48","author":"RA Ceredig","year":"2018","unstructured":"Ceredig RA, Pierre F, Doridot S, Alduntzin U, Salvat E, Yalcin I, Gaveriaux-Ruff C, Barrot M, Massotte D (2018) Peripheral delta opioid receptors mediate duloxetine antiallodynic effect in a mouse model of neuropathic pain. Eur J Neurosci 48(5):2231\u20132246","journal-title":"Eur J Neurosci"},{"key":"5443_CR18","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.neulet.2017.04.017","volume":"649","author":"M Chen","year":"2017","unstructured":"Chen M, Hoshino H, Saito S, Yang Y, Obata H (2017) Spinal dopaminergic involvement in the antihyperalgesic effect of antidepressants in a rat model of neuropathic pain. Neurosci Lett 649:16\u2013123","journal-title":"Neurosci Lett"},{"key":"5443_CR19","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.brainres.2013.12.016","volume":"1546","author":"N Choucair-Jaafar","year":"2014","unstructured":"Choucair-Jaafar N, Salvat E, Freund-Mercier MJ, Barrot M (2014) The antiallodynic action of nortriptyline and terbutaline is mediated by \u03b2(2) adrenoceptors and \u03b4 opioid receptors in the ob\/ob model of diabetic polyneuropathy. Brain Res 1546:18\u201326","journal-title":"Brain Res"},{"key":"5443_CR20","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/BF00455973","volume":"10","author":"H Corrodi","year":"1966","unstructured":"Corrodi H, Hanson LC (1966) Central effects of an inhibitor of tyrosine hydroxylation. Psychopharmacologia 10:116\u2013125","journal-title":"Psychopharmacologia"},{"issue":"1","key":"5443_CR21","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1097\/YCO.0b013e32835a4206","volume":"26","author":"M Deuschle","year":"2013","unstructured":"Deuschle M (2013) Effects of antidepressants on glucose metabolism and diabetes mellitus type 2 in adults. Curr Opin Psychiatry 26(1):60\u201365","journal-title":"Curr Opin Psychiatry"},{"issue":"1","key":"5443_CR22","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1002\/jnr.21815","volume":"87","author":"L Di Cesare Mannelli","year":"2009","unstructured":"Di Cesare Mannelli L, Ghelardini C, Calvani M, Nicolai R, Mosconi L, Toscano A, Pacini A, Bartolini A (2009) Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: a role for the nicotinic receptor. J Neurosci Res 87(1):200\u2013207","journal-title":"J Neurosci Res"},{"key":"5443_CR23","first-page":"269","volume":"99","author":"A Dierich","year":"2004","unstructured":"Dierich A, Kieffer BL (2004) Knockout mouse models in pain research. Methods Mol Med 99:269\u2013299","journal-title":"Methods Mol Med"},{"issue":"3 Suppl","key":"5443_CR24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4065\/mcp.2009.0649","volume":"85","author":"RH Dworkin","year":"2010","unstructured":"Dworkin RH, O\u2019Connor AB, Audette J, Baron R, Gourlay GK, Haanp\u00e4\u00e4 ML, Kent JL, Krane EJ, Lebel AA, Levy RM, Mackey SC, Mayer J, Miaskowski C, Raja SN, Rice AS, Schmader KE, Stacey B, Stanos S, Treede RD, Turk DC, Walco GA, Wells CD (2010) Recommendations for the pharmacological management of neuropathic pain: an overview and literat\u00fcre update. Mayo Clin Proc 85(3 Suppl):3\u201314","journal-title":"Mayo Clin Proc"},{"key":"5443_CR25","doi-asserted-by":"publisher","first-page":"c4737","DOI":"10.1136\/bmj.c4737","volume":"341","author":"D Eyding","year":"2010","unstructured":"Eyding D, Lelgemann M, Grouven U, H\u00e4rter M, Kromp M, Kaiser T, Kerekes MF, Gerken M, Wieseler B (2010) Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials. BMJ 341:c4737","journal-title":"BMJ"},{"issue":"2","key":"5443_CR26","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","volume":"14","author":"NB Finnerup","year":"2015","unstructured":"Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, Gilron I, Haanp\u00e4\u00e4 M, Hansson P, Jensen TS, Kamerman PR, Lund K, Moore A, Raja SN, Rice AS, Rowbotham M, Sena E, Siddall P, Smith BH, Wallace M (2015) Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol 14(2):162\u2013173","journal-title":"Lancet Neurol"},{"issue":"21","key":"5443_CR27","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1016\/S0024-3205(99)00134-4","volume":"64","author":"LJ Forman","year":"1999","unstructured":"Forman LJ (1999) NMDA receptor antagonism produces antinociception which is partially mediated by brain opioids and dopamine. Life Sci 64(21):1877\u20131887","journal-title":"Life Sci"},{"issue":"2","key":"5443_CR28","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.neuroscience.2007.08.002","volume":"149","author":"AJ Fulford","year":"2007","unstructured":"Fulford AJ, Marsden CA (2007) An intact dopaminergic system is required for context-conditioned release of 5-HT in the nucleus accumbens of postweaning isolation-reared rats. Neuroscience 149(2):392\u2013400","journal-title":"Neuroscience"},{"key":"5443_CR29","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1054\/npep.2002.0900","volume":"36","author":"C Gaveriaux-Ruff","year":"2002","unstructured":"Gaveriaux-Ruff C, Kieffer BL (2002) Opioid receptor genes inactivated in mice: the highlights. Neuropeptides 36:62\u201371","journal-title":"Neuropeptides"},{"key":"5443_CR30","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1016\/j.pain.2014.04.011","volume":"155","author":"JE Hartung","year":"2014","unstructured":"Hartung JE, Ciszek BP, Nackley AG (2014) \u03b22-and \u03b23-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. Pain 155:1346\u20131355","journal-title":"Pain"},{"issue":"2","key":"5443_CR31","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1097\/01.j.pain.0000460313.73358.31","volume":"156","author":"S Hughes","year":"2015","unstructured":"Hughes S, Hickey L, Donaldson LF, Lumb BM, Pickering AE (2015) Intrathecal reboxetine suppresses evoked and ongoing neuropathic pain behaviours by restoring spinal noradrenergic inhibitory tone. Pain 156(2):328\u2013334","journal-title":"Pain"},{"issue":"3","key":"5443_CR32","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.pharep.2014.12.006","volume":"67","author":"IE Ju\u00e1rez-Rojop","year":"2015","unstructured":"Ju\u00e1rez-Rojop IE, Morales-Hern\u00e1ndez PE, Tovilla-Z\u00e1rate CA, Berm\u00fadez-Oca\u00f1a DY, Torres-Lopez JE, Ble-Castillo JL, D\u00edaz-Zagoya JC, Granados-Soto V (2015) Celecoxib reduces hyperalgesia and tactile allodynia in diabetic rats. Pharmacol Rep 67(3):545\u2013552","journal-title":"Pharmacol Rep"},{"issue":"6","key":"5443_CR33","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1111\/j.1472-8206.2005.00373.x","volume":"19","author":"R Khanam","year":"2005","unstructured":"Khanam R, Pillai KK (2005) Lack of hypo\/hyperglycemic effects of reboxetine in diabetic and non-diabetic rats. Fundam Clin Pharmacol 19(6):657\u2013659","journal-title":"Fundam Clin Pharmacol"},{"issue":"1","key":"5443_CR34","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.neulet.2012.08.008","volume":"529","author":"M Kimura","year":"2012","unstructured":"Kimura M, Saito S, Obata H (2012) Dexmedetomidine decreases hyperalgesia in neuropathic pain by increasing acetylcholine in the spinal cord. Neurosci Lett 529(1):70\u201374","journal-title":"Neurosci Lett"},{"issue":"5","key":"5443_CR35","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1176\/appi.psy.46.5.379","volume":"46","author":"HV Krell","year":"2005","unstructured":"Krell HV, Leuchter AF, Cook IA, Abrams M (2005) Evaluation of reboxetine, a noradrenergic antidepressant, for the treatment of fibromyalgia and chronic low back pain. Psychosomatics 46(5):379\u2013384","journal-title":"Psychosomatics"},{"key":"5443_CR36","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.neuroscience.2016.06.057","volume":"338","author":"M Kremer","year":"2016","unstructured":"Kremer M, Salvat E, Muller A, Yalcin I, Barrot M (2016) Antidepressants and gabapentinoids in neuropathic pain: mechanistic insights. Neuroscience 338:183\u2013206","journal-title":"Neuroscience"},{"issue":"46","key":"5443_CR37","doi-asserted-by":"publisher","first-page":"9934","DOI":"10.1523\/JNEUROSCI.1004-18.2018","volume":"38","author":"M Kremer","year":"2018","unstructured":"Kremer M, Yalcin I, Goumon Y, Wurtz X, Nexon L, Daniel D, Megat S, Ceredig RA, Ernst C, Turecki G, Chavant V, Th\u00e9roux JF, Lacaud A, Joganah LE, Lelievre V, Massotte D, Lutz PE, Gilsbach R, Salvat E, Barrot M (2018) A dual noradrenergic mechanism for the relief of neuropathic allodynia by the antidepressant drugs duloxetine and amitriptyline. J Neurosci 38(46):9934\u20139954","journal-title":"J Neurosci"},{"issue":"4","key":"5443_CR38","doi-asserted-by":"publisher","first-page":"407","DOI":"10.4196\/kjpp.2016.20.4.407","volume":"20","author":"JH Lee","year":"2016","unstructured":"Lee JH, Go D, Kim W, Lee G, Bae H, Quan FS, Kim SK (2016) Involvement of spinal muscarinic and serotonergic receptors in the anti-allodynic effect of electroacupuncture in rats with oxaliplatin-induced neuropathic pain. Korean J Physiol Pharmacol 20(4):407\u2013414","journal-title":"Korean J Physiol Pharmacol"},{"issue":"2","key":"5443_CR39","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","volume":"51","author":"S Lenzen","year":"2008","unstructured":"Lenzen S (2008) The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 51(2):216\u2013226","journal-title":"Diabetologia"},{"issue":"1\u20132","key":"5443_CR40","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0304-3959(98)00037-2","volume":"76","author":"M Malcangio","year":"1998","unstructured":"Malcangio M, Tomlinson DR (1998) A pharmacologic analysis of mechanical hyperalgesia in streptozotocin\/diabetic rats. Pain 76(1\u20132):151\u2013157","journal-title":"Pain"},{"issue":"19","key":"5443_CR41","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1056\/NEJM199205073261904","volume":"326","author":"MB Max","year":"1992","unstructured":"Max MB, Lynch SA, Muir J, Shoaf SE, Smoller B, Dubner R (1992) Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy. N Engl J Med 326(19):1250\u20131256","journal-title":"N Engl J Med"},{"issue":"7","key":"5443_CR42","doi-asserted-by":"publisher","first-page":"e0180998","DOI":"10.1371\/journal.pone.0180998","volume":"12","author":"C McDonnell","year":"2017","unstructured":"McDonnell C, Le\u00e1nez S, Pol O (2017) The induction of the transcription factor Nrf2 enhances the antinociceptive effects of delta-opioid receptors in diabetic mice. PLoS One 12(7):e0180998","journal-title":"PLoS One"},{"key":"5443_CR43","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1146\/annurev.neuro.23.1.777","volume":"23","author":"JS Mogil","year":"2000","unstructured":"Mogil JS, Yu L, Basbaum AI (2000) Pain genes?: natural variation and transgenic mutants. Annu Rev Neurosci 23:777\u2013811","journal-title":"Annu Rev Neurosci"},{"key":"5443_CR44","unstructured":"Niknia S, Kaeidi A, Hajizadeh MR, Mirzaei MR, Khoshdel A, Hajializadeh Z, Fahmidehkar MA, Mahmoodi M (2018) Neuroprotective and antihyperalgesic effects of orexin-a in rats with painful diabetic neuropathy. Neuropeptides (18):30111\u201330112"},{"issue":"2","key":"5443_CR45","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1177\/026988119300700205","volume":"7","author":"K Njung\u2019e","year":"1993","unstructured":"Njung\u2019e K, Critchley MA, Handley SL (1993) Effects of beta-adrenoceptor ligands in the elevated X-maze \u2018anxiety\u2019 model and antagonism of the \u2018anxiogenic\u2019 response to 8-OH-DPAT. J Psychopharmacol 7(2):173\u2013180","journal-title":"J Psychopharmacol"},{"issue":"11","key":"5443_CR46","doi-asserted-by":"publisher","first-page":"E2483","DOI":"10.3390\/ijms18112483","volume":"18","author":"H Obata","year":"2017","unstructured":"Obata H (2017) Analgesic mechanisms of antidepressants for neuropathic pain. Int J Mol Sci 18(11):E2483","journal-title":"Int J Mol Sci"},{"key":"5443_CR47","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.pbb.2007.08.001","volume":"88","author":"A Onal","year":"2007","unstructured":"Onal A, Parlar A, Ulker S (2007) Milnacipran attenuates hyperalgesia and potentiates antihyperalgesic effect of tramadol in rats with mononeuropathic pain. Pharmacol Biochem Behav 88:171\u2013178","journal-title":"Pharmacol Biochem Behav"},{"issue":"2","key":"5443_CR48","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.jep.2010.10.046","volume":"133","author":"KW Ong","year":"2011","unstructured":"Ong KW, Hsu A, Song L, Huang D, Tan BK (2011) Polyphenols-rich Vernonia amygdalina shows anti-diabetic effects in streptozotocin-induced diabetic rats. J Ethnopharmacol 133(2):598\u2013607","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"5443_CR49","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1527-3458.2003.tb00258.x","volume":"9","author":"ME Page","year":"2003","unstructured":"Page ME (2003) The promises and pitfalls of reboxetine. CNS Drug Rev 9(4):327\u2013342","journal-title":"CNS Drug Rev"},{"key":"5443_CR50","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.lfs.2018.10.059","volume":"214","author":"U Pecikoza","year":"2018","unstructured":"Pecikoza U, Micov A, Tomi\u0107 M, Stepanovi\u0107-Petrovi\u0107 R (2018) Eslicarbazepine acetate reduces trigeminal nociception: possible role of adrenergic, cholinergic and opioid receptors. Life Sci 214:167\u2013175","journal-title":"Life Sci"},{"issue":"4","key":"5443_CR51","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00213-005-0120-6","volume":"182","author":"LH Pedersen","year":"2005","unstructured":"Pedersen LH, Nielsen AN, Blackburn-Munro G (2005) Anti-nociception is selectively enhanced by parallel inhibition of multiple subtypes of monoamine transporters in rat models of persistent and neuropathic pain. Psychopharmacology 182(4):551\u2013561","journal-title":"Psychopharmacology"},{"key":"5443_CR52","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.ejphar.2013.01.067","volume":"716","author":"A Pertovaara","year":"2013","unstructured":"Pertovaara A (2013) The noradrenergic pain regulation system: a potential target for pain therapy. Eur J Pharmacol 716:2\u20137","journal-title":"Eur J Pharmacol"},{"key":"5443_CR53","unstructured":"Pitsikas N, Boultadakis A, Georgiadou G, Tarantilis PA, Sakellaridis N (2008) Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety. Phytomed 15(12):1135\u20131139"},{"issue":"10","key":"5443_CR54","doi-asserted-by":"publisher","first-page":"3208","DOI":"10.2337\/dc13-0012","volume":"36","author":"R Pop-Busui","year":"2013","unstructured":"Pop-Busui R, Lu J, Brooks MM, Albert S, Althouse AD, Escobedo J, Green J, Palumbo P, Perkins BA, Whitehouse F, Jones TL, BARI 2D Study Group (2013) Impact of glycemic control strategies on the progression of diabetic peripheral neuropathy in the bypass angioplasty revascularization investigation 2 diabetes (BARI 2D) cohort. Diabetes Care 36(10):3208\u20133215","journal-title":"Diabetes Care"},{"issue":"1","key":"5443_CR55","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1097\/00131746-200401000-00006","volume":"10","author":"SH Preskorn","year":"2004","unstructured":"Preskorn SH (2004) Reboxetine: a norepinephrine selective reuptake pump inhibitor. J Psychiatr Pract 10(1):57\u201363","journal-title":"J Psychiatr Pract"},{"issue":"1","key":"5443_CR56","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s12576-018-0620-x","volume":"69","author":"B Rasoulian","year":"2018","unstructured":"Rasoulian B, Hajializadeh Z, Esmaeili-Mahani S, Rashidipour M, Fatemi I, Kaeidi A (2018) Neuroprotective and antinociceptive effects of rosemary (Rosmarinus officinalis L.) extract in rats with painful diabetic neuropathy. J Physiol Sci 69(1):57\u201364","journal-title":"J Physiol Sci"},{"key":"5443_CR57","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/164_2016_18","volume":"247","author":"A Saitoh","year":"2018","unstructured":"Saitoh A, Nagase H (2018) Delta opioid receptor (dor) ligands and pharmacology: development of indolo- and quinolinomorphinan derivatives based on the message-address concept. Handb Exp Pharmacol 247:3\u201319","journal-title":"Handb Exp Pharmacol"},{"issue":"10","key":"5443_CR58","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.euroneuro.2009.06.004","volume":"19","author":"S Schreiber","year":"2009","unstructured":"Schreiber S, Frishtick R, Volis I, Rubovitch V, Pick CG, Weizman R (2009) The antinociceptive properties of reboxetine in acute pain. Eur Neuropsychopharmacol 19(10):735\u2013739","journal-title":"Eur Neuropsychopharmacol"},{"issue":"3","key":"5443_CR59","doi-asserted-by":"publisher","first-page":"432","DOI":"10.4239\/wjd.v6.i3.432","volume":"6","author":"AK Schreiber","year":"2015","unstructured":"Schreiber AK, Nones CFM, Reis RC, Chichorro JG, Cunha JM (2015) Diabetic neuropathic pain: physiopathology and treatment. World J Diabetes 6(3):432\u2013444","journal-title":"World J Diabetes"},{"issue":"2","key":"5443_CR60","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s00115-001-1226-7","volume":"73","author":"P Sch\u00fcler","year":"2002","unstructured":"Sch\u00fcler P, Seibel K, Chevts V, Schaffler K (2002) Analgesic effect of the selective noradrenaline reuptake inhibitor reboxetine. Nervenarzt 73(2):149\u2013154","journal-title":"Nervenarzt"},{"issue":"4","key":"5443_CR61","first-page":"e255","volume":"163","author":"G Sepede","year":"2012","unstructured":"Sepede G, Corbo M, Fiori F, Martinotti G (2012) Reboxetine in clinical practice: a review. Clin Ter 163(4):e255\u2013e262","journal-title":"Clin Ter"},{"key":"5443_CR62","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.phrs.2013.12.005","volume":"80","author":"R Singh","year":"2014","unstructured":"Singh R, Kishore L, Kaur N (2014) Diabetic peripheral neuropathy: current perspective and future directions. Pharm Res 80:21\u201335","journal-title":"Pharm Res"},{"key":"5443_CR63","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1007\/s11916-009-0035-8","volume":"13","author":"BK Taylor","year":"2009","unstructured":"Taylor BK (2009) Spinal inhibitory neurotransmission in neuropathic pain. Curr Pain Headache Rep 13:208\u2013214","journal-title":"Curr Pain Headache Rep"},{"issue":"6","key":"5443_CR64","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1097\/j.pain.0000000000000494","volume":"157","author":"AM Taylor","year":"2016","unstructured":"Taylor AM, Becker S, Schweinhardt P, Cahill C (2016) Mesolimbic dopamine signaling in acute and chronic pain: implications for motivation, analgesia, and addiction. Pain 157(6):1194\u20131198","journal-title":"Pain"},{"issue":"9","key":"5443_CR65","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1177\/0748233712463779","volume":"30","author":"VR Thiagarajan","year":"2014","unstructured":"Thiagarajan VR, Shanmugam P, Krishnan UM, Muthuraman A (2014) Ameliorative effect of Vernonia cinerea in vincristine-induced painful neuropathy in rats. Toxicol Ind Health 30(9):794\u2013805","journal-title":"Toxicol Ind Health"},{"key":"5443_CR66","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ejphar.2015.02.048","volume":"756","author":"U\u0130 \u00dc\u00e7el","year":"2015","unstructured":"\u00dc\u00e7el U\u0130, Can \u00d6D, Demir \u00d6zkay \u00dc, \u00d6zt\u00fcrk Y (2015) Antihyperalgesic and antiallodynic effects of mianserin on diabetic neuropathic pain: a study on mechanism of action. Eur J Pharmacol 756:92\u2013106","journal-title":"Eur J Pharmacol"},{"key":"5443_CR67","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2147\/DMSO.S24825","volume":"6","author":"AI Vinik","year":"2013","unstructured":"Vinik AI, Casellini CM (2013) Guidelines in the management of diabetic nerve pain: clinical utility of pregabalin. Diabetes Metab Syndr Obes 6:57\u201378","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"6","key":"5443_CR68","doi-asserted-by":"publisher","first-page":"284","DOI":"10.9740\/mhc.2015.11.284","volume":"5","author":"M Webster","year":"2015","unstructured":"Webster M (2015) Pharmacologic basis for the use of selective norepinephrine reuptake inhibitors for the treatment of neuropathic pain conditions. Ment Health Clin 5(6):284\u2013288","journal-title":"Ment Health Clin"},{"issue":"8","key":"5443_CR69","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1177\/0269881113492027","volume":"27","author":"E Whiskey","year":"2013","unstructured":"Whiskey E, Taylor D (2013) A review of the adverse effects and safety of noradrenergic antidepressants. J Psychopharmacol 27(8):732\u2013739","journal-title":"J Psychopharmacol"},{"key":"5443_CR70","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/BF00495547","volume":"304","author":"E Widerlov","year":"1978","unstructured":"Widerlov E, Lewander T (1978) Inhibition of the in vivo biosynthesis and changes of catecholamine levels in rat brain after a-methyl-ptyrosine; time-and dose\u2013response relationships. Naunyn Schmiedeberg's Arch Pharmacol 304:111\u2013123","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"issue":"3","key":"5443_CR71","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.nbd.2008.11.003","volume":"33","author":"I Yalcin","year":"2009","unstructured":"Yalcin I, Tessier LH, Petit-Demouli\u00e8re N, Doridot S, Hein L, Freund-Mercier MJ, Barrot M (2009a) Beta2-adrenoceptors are essential for desipramine, venlafaxine or reboxetine action in neuropathic pain. Neurobiol Dis 33(3):386\u2013394","journal-title":"Neurobiol Dis"},{"issue":"2","key":"5443_CR72","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/ana.21542","volume":"65","author":"I Yalcin","year":"2009","unstructured":"Yalcin I, Choucair-Jaafar N, Benbouzid M, Tessier LH, Muller A, Hein L, Freund-Mercier MJ, Barrot M (2009b) Beta(2)-adrenoceptors are critical for antidepressant treatment of neuropathic pain. Ann Neurol 65(2):218\u2013225","journal-title":"Ann Neurol"},{"issue":"1","key":"5443_CR73","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.expneurol.2009.10.008","volume":"221","author":"I Yalcin","year":"2010","unstructured":"Yalcin I, Tessier LH, Petit-Demouli\u00e8re N, Waltisperger E, Hein L, Freund-Mercier MJ, Barrot M (2010) Chronic treatment with agonists of beta(2)-adrenergic receptors in neuropathic pain. Exp Neurol 221(1):115\u2013121","journal-title":"Exp Neurol"},{"key":"5443_CR74","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1097\/01.j.pain.0000460343.46847.58","volume":"156","author":"D Yarnitsky","year":"2015","unstructured":"Yarnitsky D (2015) Role of endogenous pain modulation in chronic pain mechanisms and treatment. Pain 156:24\u201331","journal-title":"Pain"},{"key":"5443_CR75","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.bbi.2018.06.017","volume":"73","author":"X Zhang","year":"2018","unstructured":"Zhang X, Hartung JE, Bortsov AV, Kim S, O\u2019Buckley SC, Kozlowski J, Nackley AG (2018) Sustained stimulation of \u03b22- and \u03b23-adrenergic receptors leads to persistent functional pain and neuroinflammation. Brain Behav Immun 73:520\u2013532","journal-title":"Brain Behav Immun"},{"key":"5443_CR76","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.expneurol.2013.07.004","volume":"248","author":"JX Zhu","year":"2013","unstructured":"Zhu JX, Xu FY, Xu WJ, Zhao Y, Qu CL, Tang JS, Barry DM, Du JQ, Huo FQ (2013) The role of adrenoceptor in mediating noradrenaline action in the ventrolateralorbital cortex on allodynia following spared nerve injury. Exp Neurol 248:381\u2013386","journal-title":"Exp Neurol"},{"key":"5443_CR77","doi-asserted-by":"publisher","first-page":"16109","DOI":"10.1038\/srep16109","volume":"5","author":"L Zhu","year":"2015","unstructured":"Zhu L, Zhao L, Qu R, Zhu HY, Wang Y, Jiang X, Xu GY (2015) Adrenergic stimulation sensitizes TRPV1 through upregulation of cystathionine \u03b2-synthetase in a rat model of visceral hypersensitivity. Sci Rep 5:16109","journal-title":"Sci Rep"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-019-05443-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-019-05443-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-019-05443-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T19:26:57Z","timestamp":1609874817000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-019-05443-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,7]]},"references-count":77,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["5443"],"URL":"https:\/\/doi.org\/10.1007\/s00213-019-05443-5","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,7]]},"assertion":[{"value":"22 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The experimental protocol was approved by the Animal Experiments Local Ethics Committee of Anadolu University.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}