{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:17:07Z","timestamp":1763018227276,"version":"3.37.3"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Dobberke Foundation","award":["UPS\/BP\/4151 2016-27"],"award-info":[{"award-number":["UPS\/BP\/4151 2016-27"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Rationale<\/jats:title>\n<jats:p>Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (SCN) is known to be modulated by serotonin and it is therefore assumed that SSRIs may affect circadian rhythms. However, effects of perinatal SSRI treatment on circadian system functioning in the offspring are largely unknown.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>Our aim was to investigate the effects of perinatal exposure to the SSRI fluoxetine (FLX) on circadian behavior, affective behavior, and 5-HT<jats:sub>1A<\/jats:sub> receptor sensitivity in female rats. In addition, we studied the expression of clock genes and the 5-HT<jats:sub>1A<\/jats:sub> receptor in the SCN, as they are potentially involved in underlying mechanisms contributing to changes in circadian rhythms.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Perinatal FLX exposure shortened the free-running tau in response to the 5-HT<jats:sub>1A\/7<\/jats:sub> agonist 8-OH-DPAT. However, FLX exposure did not alter anxiety, stress coping, and 5-HT<jats:sub>1A<\/jats:sub> receptor sensitivity. No differences were found in 5-HT<jats:sub>1A<\/jats:sub> receptor and clock genes Per1, Per2, Cry1, and Cry2 SCN gene expression.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Perinatal FLX exposure altered the response to a phase-shifting challenge in female rats, whether this may pose health risks remains to be investigated.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00213-020-05556-2","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T21:02:26Z","timestamp":1591995746000},"page":"2555-2568","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Perinatal fluoxetine exposure disrupts the circadian response to a phase-shifting challenge in female rats"],"prefix":"10.1007","volume":"237","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-2542","authenticated-orcid":false,"given":"Danielle J.","family":"Houwing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolien","family":"de Waard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anouschka S.","family":"Ramsteijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Woelders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sietse F.","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma J.","family":"Wams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelien D. A.","family":"Olivier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"key":"5556_CR1","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1021\/cn3002174","volume":"4","author":"SC Altieri","year":"2013","unstructured":"Altieri SC, Garcia-Garcia AL, Leonardo ED, Andrews AM (2013) Rethinking 5-HT1A receptors: emerging modes of inhibitory feedback of relevance to emotion-related behavior. ACS Chem Neurosci 4:72\u201383. https:\/\/doi.org\/10.1021\/cn3002174","journal-title":"ACS Chem Neurosci"},{"key":"5556_CR2","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1038\/npp.2014.331","volume":"40","author":"SC Altieri","year":"2015","unstructured":"Altieri SC, Yang H, O\u2019Brien HJ et al (2015) Perinatal vs genetic programming of serotonin states associated with anxiety. Neuropsychopharmacology 40:1456\u20131470. https:\/\/doi.org\/10.1038\/npp.2014.331","journal-title":"Neuropsychopharmacology"},{"issue":"80","key":"5556_CR3","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1126\/science.1101678","volume":"306","author":"MS Ansorge","year":"2004","unstructured":"Ansorge MS, Zhou M, Lira A et al (2004) Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 306(80):879\u2013881. https:\/\/doi.org\/10.1126\/science.1101678","journal-title":"Science"},{"key":"5556_CR4","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1523\/JNEUROSCI.3973-07.2008","volume":"28","author":"MS Ansorge","year":"2008","unstructured":"Ansorge MS, Morelli E, Gingrich JA (2008) Inhibition of serotonin but not norepinephrine transport during development produces delayed, persistent perturbations of emotional behaviors in mice. J Neurosci 28:199\u2013207. https:\/\/doi.org\/10.1523\/JNEUROSCI.3973-07.2008","journal-title":"J Neurosci"},{"key":"5556_CR5","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1097\/FBP.0000000000000303","volume":"1","author":"R Avitsur","year":"2017","unstructured":"Avitsur R (2017) Prenatal fluoxetine modifies the behavioral and hormonal responses to stress in male mice. Behav Pharmacol 1:345\u2013355. https:\/\/doi.org\/10.1097\/FBP.0000000000000303","journal-title":"Behav Pharmacol"},{"key":"5556_CR6","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/dev.21385","volume":"58","author":"F Boulle","year":"2016","unstructured":"Boulle F, Pawluski JL, Homberg JR, Machiels B, Kroeze Y, Kumar N, Steinbusch HWM, Kenis G, van den Hove DLA (2016a) Prenatal stress and early-life exposure to fluoxetine have enduring effects on anxiety and hippocampal BDNF gene expression in adult male offspring. Dev Psychobiol 58:427\u2013438. https:\/\/doi.org\/10.1002\/dev.21385","journal-title":"Dev Psychobiol"},{"key":"5556_CR7","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.yhbeh.2016.01.017","volume":"80","author":"F Boulle","year":"2016","unstructured":"Boulle F, Pawluski JL, Homberg JR, Machiels B, Kroeze Y, Kumar N, Steinbusch HWM, Kenis G, van den Hove DLA (2016b) Developmental fluoxetine exposure increases behavioral despair and alters epigenetic regulation of the hippocampal BDNF gene in adult female offspring. Horm Behav 80:47\u201357. https:\/\/doi.org\/10.1016\/j.yhbeh.2016.01.017","journal-title":"Horm Behav"},{"key":"5556_CR8","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1093\/ije\/dyv030","volume":"44","author":"RE Brandlistuen","year":"2015","unstructured":"Brandlistuen RE, Ystrom E, Eberhard-Gran M, Nulman I, Koren G, Nordeng H (2015) Behavioural effects of fetal antidepressant exposure in a Norwegian cohort of discordant siblings. Int J Epidemiol 44:1397\u20131407. https:\/\/doi.org\/10.1093\/ije\/dyv030","journal-title":"Int J Epidemiol"},{"key":"5556_CR9","doi-asserted-by":"publisher","first-page":"544.e1","DOI":"10.1016\/j.ajog.2007.01.033","volume":"196","author":"WO Cooper","year":"2007","unstructured":"Cooper WO, Willy ME, Pont SJ, Ray WA (2007) Increasing use of antidepressants in pregnancy. Am J Obstet Gynecol 196:544.e1\u2013544.e5. https:\/\/doi.org\/10.1016\/j.ajog.2007.01.033","journal-title":"Am J Obstet Gynecol"},{"key":"5556_CR10","doi-asserted-by":"publisher","first-page":"5351","DOI":"10.1523\/jneurosci.21-14-05351.2001","volume":"21","author":"EJ Ehlen","year":"2001","unstructured":"Ehlen EJ, Grossman GH, David Glass J (2001) In vivo resetting of the hamster circadian clock by 5-HT7 receptors in the suprachiasmatic nucleus. J Neurosci 21:5351\u20135357. https:\/\/doi.org\/10.1523\/jneurosci.21-14-05351.2001","journal-title":"J Neurosci"},{"key":"5556_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fncel.2017.00222","volume":"11","author":"S El Aidy","year":"2017","unstructured":"El Aidy S, Ramsteijn AS, Dini-Andreote F et al (2017) Serotonin transporter genotype modulates the gut microbiota composition in young rats, an effect augmented by early life stress. Front Cell Neurosci 11:1\u201312. https:\/\/doi.org\/10.3389\/fncel.2017.00222","journal-title":"Front Cell Neurosci"},{"key":"5556_CR12","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1001\/archgenpsychiatry.2011.2333","volume":"69","author":"H El Marroun","year":"2012","unstructured":"El Marroun H, Jaddoe VWV, Hudziak JJ et al (2012) Maternal use of selective serotonin reuptake inhibitors, fetal growth, and risk of adverse birth outcomes. Arch Gen Psychiatry 69:706\u2013714. https:\/\/doi.org\/10.1001\/archgenpsychiatry.2011.2333","journal-title":"Arch Gen Psychiatry"},{"key":"5556_CR13","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0014-2999(92)90662-N","volume":"210","author":"A Fern\u00e1ndez-Guasti","year":"1992","unstructured":"Fern\u00e1ndez-Guasti A, Escalante AL, Ahlenius S, Hillegaart V, Larsson K (1992) Stimulation of 5-HT1A and 5-HT1B receptors in brain regions and its effects on male rat sexual behaviour. Eur J Pharmacol 210:121\u2013129. https:\/\/doi.org\/10.1016\/0014-2999(92)90662-N","journal-title":"Eur J Pharmacol"},{"key":"5556_CR14","first-page":"1029","volume":"46","author":"MC Frink","year":"1996","unstructured":"Frink MC, Hennies HH, Englberger W, Haurand M, Wilffert B (1996) Influence of tramadol on neurotransmitter systems of the rat brain. Arzneimittel-Forschung 46:1029\u20131036","journal-title":"Arzneimittel-Forschung"},{"key":"5556_CR15","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.celrep.2017.01.021","volume":"18","author":"AL Garcia-Garcia","year":"2017","unstructured":"Garcia-Garcia AL, Meng Q, Canetta S, Gardier AM, Guiard BP, Kellendonk C, Dranovsky A, Leonardo ED (2017) Serotonin signaling through prefrontal cortex 5-HT1A receptors during adolescence can determine baseline mood-related behaviors. Cell Rep 18:1144\u20131156. https:\/\/doi.org\/10.1016\/j.celrep.2017.01.021","journal-title":"Cell Rep"},{"key":"5556_CR16","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1038\/nrn1256","volume":"4","author":"P Gaspar","year":"2003","unstructured":"Gaspar P, Cases O, Maroteaux L (2003) The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 4:1002\u20131012. https:\/\/doi.org\/10.1038\/nrn1256","journal-title":"Nat Rev Neurosci"},{"key":"5556_CR17","doi-asserted-by":"publisher","unstructured":"Gaynes BN, Gavin N, Meltzer-Brody S, Lohr KN, Swinson T, Gartlehner G, Brody S, Miller WC (2005) Perinatal depression: prevalence, screening accuracy, and screening outcomes. Evid Rep Technol Assess (Summ):1\u20138. https:\/\/doi.org\/10.1037\/e439372005-001","DOI":"10.1037\/e439372005-001"},{"key":"5556_CR18","doi-asserted-by":"publisher","first-page":"623","DOI":"10.2165\/00023210-200519070-00004","volume":"19","author":"S Gentile","year":"2005","unstructured":"Gentile S (2005) SSRIs in pregnancy and lactation. CNS Drugs 19:623\u2013633. https:\/\/doi.org\/10.2165\/00023210-200519070-00004","journal-title":"CNS Drugs"},{"key":"5556_CR19","first-page":"33","volume":"54","author":"MU Gillette","year":"1999","unstructured":"Gillette MU, Tischkau SA (1999) Suprachiasmatic nucleus: the brain\u2019s circadian clock. Recent Prog Horm Res 54:33\u201359","journal-title":"Recent Prog Horm Res"},{"key":"5556_CR20","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.earlhumdev.2012.12.012","volume":"89","author":"GE Hanley","year":"2013","unstructured":"Hanley GE, Brain U, Oberlander TF (2013) Infant developmental outcomes following prenatal exposure to antidepressants, and maternal depressed mood and positive affect. Early Hum Dev 89:519\u2013524. https:\/\/doi.org\/10.1016\/j.earlhumdev.2012.12.012","journal-title":"Early Hum Dev"},{"key":"5556_CR21","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/pr.2015.77","volume":"78","author":"GE Hanley","year":"2015","unstructured":"Hanley GE, Brain U, Oberlander TF (2015) Prenatal exposure to serotonin reuptake inhibitor antidepressants and childhood behavior. Pediatr Res 78:174\u2013180. https:\/\/doi.org\/10.1038\/pr.2015.77","journal-title":"Pediatr Res"},{"key":"5556_CR22","doi-asserted-by":"publisher","first-page":"49.e1","DOI":"10.1016\/j.ajog.2012.04.028","volume":"207","author":"RM Hayes","year":"2012","unstructured":"Hayes RM, Wu P, Shelton RC et al (2012) Maternal antidepressant use and adverse outcomes: a cohort study of 228,876 pregnancies. Am J Obstet Gynecol 207:49.e1\u201349.e9. https:\/\/doi.org\/10.1016\/j.ajog.2012.04.028","journal-title":"Am J Obstet Gynecol"},{"key":"5556_CR23","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/S0009-9236(02)17634-X","volume":"73","author":"T Heikkinen","year":"2003","unstructured":"Heikkinen T, Ekblad U, Palo P, Laine K (2003) Pharmacokinetics of fluoxetine and norfluoxetine in pregnancy and lactation. Clin Pharmacol Ther 73:330\u2013337. https:\/\/doi.org\/10.1016\/S0009-9236(02)17634-X","journal-title":"Clin Pharmacol Ther"},{"key":"5556_CR24","doi-asserted-by":"publisher","first-page":"5867","DOI":"10.1523\/jneurosci.20-15-05867.2000","volume":"20","author":"K Horikawa","year":"2000","unstructured":"Horikawa K, Yokota SI, Fuji K, Akiyama M, Moriya T, Okamura H, Shibata S (2000) Nonphotic entrainment by 5-HT(1a\/7) receptor agonists accompanied by reduced Per1 and Per2 mRNA levels in the suprachiasmatic nuclei. J Neurosci 20:5867\u20135873. https:\/\/doi.org\/10.1523\/jneurosci.20-15-05867.2000","journal-title":"J Neurosci"},{"key":"5556_CR25","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.bbr.2018.08.031","volume":"356","author":"DJ Houwing","year":"2019","unstructured":"Houwing DJ, Ramsteijn AS, Riemersma IW, Olivier JDA (2019a) Maternal separation induces anhedonia in female heterozygous serotonin transporter knockout rats. Behav Brain Res 356:204\u2013207. https:\/\/doi.org\/10.1016\/j.bbr.2018.08.031","journal-title":"Behav Brain Res"},{"key":"5556_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnins.2019.00229","volume":"13","author":"DJ Houwing","year":"2019","unstructured":"Houwing DJ, Staal L, Swart JM, Ramsteijn AS, W\u00f6hr M, de Boer SF, Olivier JDA (2019b) Subjecting dams to early life stress and perinatal fluoxetine treatment differentially alters social behavior in young and adult rat offspring. Front Neurosci 13:1\u201315. https:\/\/doi.org\/10.3389\/fnins.2019.00229","journal-title":"Front Neurosci"},{"key":"5556_CR27","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.euroneuro.2008.09.002","volume":"19","author":"NN Karpova","year":"2009","unstructured":"Karpova NN, Lindholm J, Pruunsild P, Timmusk T, Castr\u00e9n E (2009) Long-lasting behavioural and molecular alterations induced by early postnatal fluoxetine exposure are restored by chronic fluoxetine treatment in adult mice. Eur Neuropsychopharmacol 19:97\u2013108. https:\/\/doi.org\/10.1016\/j.euroneuro.2008.09.002","journal-title":"Eur Neuropsychopharmacol"},{"key":"5556_CR28","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s00213-012-2861-3","volume":"225","author":"V Kiryanova","year":"2013","unstructured":"Kiryanova V, Smith VM, Dyck RH, Antle MC (2013) The effects of perinatal fluoxetine treatment on the circadian system of the adult mouse. Psychopharmacology 225:743\u2013751. https:\/\/doi.org\/10.1007\/s00213-012-2861-3","journal-title":"Psychopharmacology"},{"key":"5556_CR29","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s00213-016-4515-3","volume":"234","author":"V Kiryanova","year":"2017","unstructured":"Kiryanova V, Smith VM, Dyck RH, Antle MC (2017) Circadian behavior of adult mice exposed to stress and fluoxetine during development. Psychopharmacology 234:793\u2013804. https:\/\/doi.org\/10.1007\/s00213-016-4515-3","journal-title":"Psychopharmacology"},{"key":"5556_CR30","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1002\/dneu.22185","volume":"74","author":"MC Ko","year":"2014","unstructured":"Ko MC, Lee LJH, Li Y, Lee LJ (2014) Long-term consequences of neonatal fluoxetine exposure in adult rats. Dev Neurobiol 74:1038\u20131051. https:\/\/doi.org\/10.1002\/dneu.22185","journal-title":"Dev Neurobiol"},{"key":"5556_CR31","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0092-8674(00)81014-4","volume":"98","author":"K Kume","year":"1999","unstructured":"Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM (1999) mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98:193\u2013205. https:\/\/doi.org\/10.1016\/S0092-8674(00)81014-4","journal-title":"Cell"},{"key":"5556_CR32","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/BF00176767","volume":"352","author":"E Le Poul","year":"1995","unstructured":"Le Poul E, Laaris N, Doucet E et al (1995) In rats treated with fluoxetine or paroxetine. Naunyn Schmiedeberg's Arch Pharmacol 352:141\u2013148","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"5556_CR33","doi-asserted-by":"crossref","unstructured":"Lesch KP, W M, H A, et al (1992) Psychopharmacology in panic disorder *. 111\u2013117","DOI":"10.1007\/BF02253597"},{"key":"5556_CR34","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1159\/000103097","volume":"80","author":"SFS Lisboa","year":"2007","unstructured":"Lisboa SFS, Oliveira PE, Costa LC, Ven\u00e2ncio EJ, Moreira EG (2007) Behavioral evaluation of male and female mice pups exposed to fluoxetine during pregnancy and lactation. Pharmacology 80:49\u201356. https:\/\/doi.org\/10.1159\/000103097","journal-title":"Pharmacology"},{"key":"5556_CR35","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.jaac.2016.02.013","volume":"55","author":"H Malm","year":"2016","unstructured":"Malm H, Brown AS, Gissler M, Gyllenberg D, Hinkka-Yli-Salom\u00e4ki S, McKeague IW, Weissman M, Wickramaratne P, Artama M, Gingrich JA, Sourander A (2016) Gestational exposure to selective serotonin reuptake inhibitors and offspring psychiatric disorders: a National Register-Based Study. J Am Acad Child Adolesc Psychiatry 55:359\u2013366. https:\/\/doi.org\/10.1016\/j.jaac.2016.02.013","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"5556_CR36","doi-asserted-by":"crossref","unstructured":"Marek GJ (2010) Electrophysiology of serotonin receptors. Elsevier B.V","DOI":"10.1016\/S1569-7339(10)70077-1"},{"key":"5556_CR37","doi-asserted-by":"publisher","first-page":"3201","DOI":"10.1007\/s00213-018-5019-0","volume":"235","author":"EM McGlashan","year":"2018","unstructured":"McGlashan EM, Nandam LS, Vidafar P et al (2018) The SSRI citalopram increases the sensitivity of the human circadian system to light in an acute dose. Psychopharmacology 235:3201\u20133209. https:\/\/doi.org\/10.1007\/s00213-018-5019-0","journal-title":"Psychopharmacology"},{"key":"5556_CR38","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1113\/jphysiol.1992.sp019147","volume":"450","author":"M Medanic","year":"1992","unstructured":"Medanic M, Gillette MU (1992) Serotonin regulates the phase of the rat suprachiasmatic circadian pacemaker in vitro only during the subjective day. J Physiol 450:629\u2013642. https:\/\/doi.org\/10.1113\/jphysiol.1992.sp019147","journal-title":"J Physiol"},{"key":"5556_CR39","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1097\/AOG.0b013e3181f60b0a.Depressive","volume":"116","author":"JL Melville","year":"2010","unstructured":"Melville JL, Gavin A, Guo YG et al (2010) Depressive disorders during pregnancy: prevalence and risk factors in a large urban sample. Obstet Gynecol 116:1064\u20131070. https:\/\/doi.org\/10.1097\/AOG.0b013e3181f60b0a.Depressive","journal-title":"Obstet Gynecol"},{"key":"5556_CR40","doi-asserted-by":"crossref","unstructured":"Morin LP (2013) Neuroanatomy of the extended circadian rhythm system","DOI":"10.1016\/j.expneurol.2012.06.026"},{"key":"5556_CR41","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1192\/bjp.bp.107.041186","volume":"193","author":"JR Nash","year":"2008","unstructured":"Nash JR, Sargent PA, Rabiner EA, Hood SD, Argyropoulos SV, Potokar JP, Grasby PM, Nutt DJ (2008) Serotonin 5-HT1A receptor binding in people with panic disorder: positron emission tomography study. Br J Psychiatry 193:229\u2013234. https:\/\/doi.org\/10.1192\/bjp.bp.107.041186","journal-title":"Br J Psychiatry"},{"key":"5556_CR42","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2217\/npy.11.12","volume":"1","author":"A Newman-Tancredi","year":"2011","unstructured":"Newman-Tancredi A (2011) Biased agonism at serotonin 5-HT1A receptors: preferential postsynaptic activity for improved therapy of CNS disorders. Neuropsychiatry (London) 1:149\u2013164. https:\/\/doi.org\/10.2217\/npy.11.12","journal-title":"Neuropsychiatry (London)"},{"key":"5556_CR43","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.lfs.2008.03.024","volume":"82","author":"K Nomura","year":"2008","unstructured":"Nomura K, Castanon-Cervantes O, Davidson A, Fukuhara C (2008) Selective serotonin reuptake inhibitors and raft inhibitors shorten the period of Period1-driven circadian bioluminescence rhythms in rat-1 fibroblasts. Life Sci 82:1169\u20131174. https:\/\/doi.org\/10.1016\/j.lfs.2008.03.024","journal-title":"Life Sci"},{"key":"5556_CR44","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1371\/journal.pone.0002782","volume":"3","author":"CW Noorlander","year":"2008","unstructured":"Noorlander CW, Ververs FFT, Nikkels PGJ, van Echteld CJA, Visser GHA, Smidt MP (2008) Modulation of serotonin transporter function during fetal development causes dilated heart cardiomyopathy and lifelong behavioral abnormalities. PLoS One 3:2\u201311. https:\/\/doi.org\/10.1371\/journal.pone.0002782","journal-title":"PLoS One"},{"key":"5556_CR45","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1001\/archpedi.161.1.22","volume":"161","author":"TF Oberlander","year":"2007","unstructured":"Oberlander TF, Reebye P, Misri S, Papsdorf M, Kim J, Grunau RE (2007) Externalizing and attentional behaviors in children of depressed mothers treated with a selective serotonin reuptake inhibitor antidepressant during pregnancy. Arch Pediatr Adolesc Med 161:22\u201329. https:\/\/doi.org\/10.1001\/archpedi.161.1.22","journal-title":"Arch Pediatr Adolesc Med"},{"key":"5556_CR46","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0014-2999(97)01482-9","volume":"342","author":"B Olivier","year":"1998","unstructured":"Olivier B, Zethof TJJ, Ronken E, Van Der Heyden JAM (1998) Anxiolytic effects of flesinoxan in the stress-induced hyperthermia paradigm in singly-housed mice are 5-HT(1A) receptor mediated. Eur J Pharmacol 342:177\u2013182. https:\/\/doi.org\/10.1016\/S0014-2999(97)01482-9","journal-title":"Eur J Pharmacol"},{"key":"5556_CR47","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1097\/00008877-200111000-00004","volume":"12","author":"B Olivier","year":"2001","unstructured":"Olivier B, Pattij T, Wood SJ, Oosting R, Sarnyai Z, Toth M (2001) The 5-HT1A receptor knockout mouse and anxiety. Behav Pharmacol 12:439\u2013450. https:\/\/doi.org\/10.1097\/00008877-200111000-00004","journal-title":"Behav Pharmacol"},{"key":"5556_CR48","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.ejphar.2008.06.008","volume":"590","author":"JDA Olivier","year":"2008","unstructured":"Olivier JDA, Cools AR, Olivier B, Homberg JR, Cuppen E, Ellenbroek BA (2008) Stress-induced hyperthermia and basal body temperature are mediated by different 5-HT1A receptor populations: a study in SERT knockout rats. Eur J Pharmacol 590:190\u2013197. https:\/\/doi.org\/10.1016\/j.ejphar.2008.06.008","journal-title":"Eur J Pharmacol"},{"key":"5556_CR49","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s00213-011-2299-z","volume":"217","author":"JDA Olivier","year":"2011","unstructured":"Olivier JDA, Vall\u00e8s A, van Heesch F, Afrasiab-Middelman A, Roelofs JJPM, Jonkers M, Peeters EJ, Korte-Bouws GAH, Dederen JP, Kiliaan AJ, Martens GJ, Schubert D, Homberg JR (2011) Fluoxetine administration to pregnant rats increases anxiety-related behavior in the offspring. Psychopharmacology 217:419\u2013432. https:\/\/doi.org\/10.1007\/s00213-011-2299-z","journal-title":"Psychopharmacology"},{"key":"5556_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fncel.2013.00073","volume":"7","author":"JDA Olivier","year":"2013","unstructured":"Olivier JDA, \u00c5kerud H, Kaihola H, Pawluski JL, Skalkidou A, H\u00f6gberg U, Sundstr\u00f6m-Poromaa I (2013) The effects of maternal depression and maternal selective serotonin reuptake inhibitor exposure on offspring. Front Cell Neurosci 7:1\u201315. https:\/\/doi.org\/10.3389\/fncel.2013.00073","journal-title":"Front Cell Neurosci"},{"key":"5556_CR51","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.neuroscience.2012.06.034","volume":"220","author":"JL Pawluski","year":"2012","unstructured":"Pawluski JL, Rayen I, Niessen NA, Kristensen S, van Donkelaar EL, Balthazart J, Steinbusch HW, Charlier TD (2012) Developmental fluoxetine exposure differentially alters central and peripheral measures of the HPA system in adolescent male and female offspring. Neuroscience 220:131\u2013141. https:\/\/doi.org\/10.1016\/j.neuroscience.2012.06.034","journal-title":"Neuroscience"},{"key":"5556_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4088\/pcc.13r01554","volume":"16","author":"KA Pierz","year":"2014","unstructured":"Pierz KA, Thase ME (2014) A review of Vilazodone, serotonin, and major depressive disorder. Prim Care Companion CNS Disord 16:1\u20138. https:\/\/doi.org\/10.4088\/pcc.13r01554","journal-title":"Prim Care Companion CNS Disord"},{"key":"5556_CR53","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/S0006-8993(02)04206-3","volume":"966","author":"RA Prosser","year":"2003","unstructured":"Prosser RA (2003) Serotonin phase-shifts the mouse suprachiasmatic circadian clock in vitro. Brain Res 966:110\u2013115. https:\/\/doi.org\/10.1016\/S0006-8993(02)04206-3","journal-title":"Brain Res"},{"key":"5556_CR54","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.neuroscience.2006.06.014","volume":"142","author":"RA Prosser","year":"2006","unstructured":"Prosser RA, Lee HM, Wehner A (2006) Serotonergic pre-treatments block in vitro serotonergic phase shifts of the mouse suprachiasmatic nucleus circadian clock. Neuroscience 142:547\u2013555. https:\/\/doi.org\/10.1016\/j.neuroscience.2006.06.014","journal-title":"Neuroscience"},{"key":"5556_CR55","doi-asserted-by":"publisher","first-page":"12379","DOI":"10.1523\/jneurosci.1020-13.2014","volume":"34","author":"TJ Rebello","year":"2014","unstructured":"Rebello TJ, Yu Q, Goodfellow NM, Caffrey Cagliostro MK, Teissier A, Morelli E, Demireva EY, Chemiakine A, Rosoklija GB, Dwork AJ, Lambe EK, Gingrich JA, Ansorge MS (2014) Postnatal day 2 to 11 constitutes a 5-HT-sensitive period impacting adult mPFC function. J Neurosci 34:12379\u201312393. https:\/\/doi.org\/10.1523\/jneurosci.1020-13.2014","journal-title":"J Neurosci"},{"key":"5556_CR56","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1076\/brhm.30.2.178.1422","volume":"30","author":"T Ruf","year":"1999","unstructured":"Ruf T (1999) The Lomb-Scargle periodogram in biological rhythm research: analysis of incomplete and unequally spaced time-series. Biol Rhythm Res 30:178\u2013201. https:\/\/doi.org\/10.1076\/brhm.30.2.178.1422","journal-title":"Biol Rhythm Res"},{"key":"5556_CR57","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.pneurobio.2009.01.009","volume":"88","author":"J Savitz","year":"2009","unstructured":"Savitz J, Lucki I, Drevets WC (2009) 5-HT1A receptor function in major depressive disorder. Prog Neurobiol 88:17\u201331. https:\/\/doi.org\/10.1016\/j.pneurobio.2009.01.009","journal-title":"Prog Neurobiol"},{"key":"5556_CR58","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/S0092-8674(00)80494-8","volume":"91","author":"Y Shigeyoshi","year":"1997","unstructured":"Shigeyoshi Y, Taguchi K, Yamamoto S, Takekida S, Yan L, Tei H, Moriya T, Shibata S, Loros JJ, Dunlap JC, Okamura H (1997) Light-induced resetting of a mammalian circadian clock is associated with rapid induction of the mPer1 transcript. Cell 91:1043\u20131053. https:\/\/doi.org\/10.1016\/S0092-8674(00)80494-8","journal-title":"Cell"},{"key":"5556_CR59","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.brainresbull.2018.09.007","volume":"142","author":"AS Silva","year":"2018","unstructured":"Silva AS, Toffoli LV, Estrada VB, Ver\u00edssimo LF, Francis-Oliveira J, Moreira EG, Gomes MV, Pelosi GG (2018) Maternal exposure to fluoxetine during gestation and lactation induces long lasting changes in the DNA methylation profile of offspring\u2019s brain and affects the social interaction of rat. Brain Res Bull 142:409\u2013413. https:\/\/doi.org\/10.1016\/j.brainresbull.2018.09.007","journal-title":"Brain Res Bull"},{"key":"5556_CR60","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.neuroscience.2008.09.030","volume":"157","author":"VM Smith","year":"2008","unstructured":"Smith VM, Sterniczuk R, Phillips CI, Antle MC (2008) Altered photic and non-photic phase shifts in 5-HT1A receptor knockout mice. Neuroscience 157:513\u2013523. https:\/\/doi.org\/10.1016\/j.neuroscience.2008.09.030","journal-title":"Neuroscience"},{"key":"5556_CR61","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1080\/07420528.2016.1184678","volume":"33","author":"MH Smolensky","year":"2016","unstructured":"Smolensky MH, Hermida RC, Reinberg A, Sackett-Lundeen L, Portaluppi F (2016) Circadian disruption: new clinical perspective of disease pathology and basis for chronotherapeutic intervention. Chronobiol Int 33:1101\u20131119. https:\/\/doi.org\/10.1080\/07420528.2016.1184678","journal-title":"Chronobiol Int"},{"key":"5556_CR62","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.psychres.2017.03.010","volume":"252","author":"LM Swanson","year":"2017","unstructured":"Swanson LM, Burgess HJ, Huntley ED, Bertram H, Mooney A, Zollars J, Dopp R, Hoffmann R, Armitage R, Todd Arnedt J (2017) Relationships between circadian measures, depression, and response to antidepressant treatment: a preliminary investigation. Psychiatry Res 252:262\u2013269. https:\/\/doi.org\/10.1016\/j.psychres.2017.03.010","journal-title":"Psychiatry Res"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-020-05556-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-020-05556-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-020-05556-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T23:13:32Z","timestamp":1623453212000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-020-05556-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,12]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["5556"],"URL":"https:\/\/doi.org\/10.1007\/s00213-020-05556-2","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"type":"print","value":"0033-3158"},{"type":"electronic","value":"1432-2072"}],"subject":[],"published":{"date-parts":[[2020,6,12]]},"assertion":[{"value":"23 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}