{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:55:06Z","timestamp":1785495306791,"version":"3.56.0"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002790","name":"Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["206686"],"award-info":[{"award-number":["206686"]}],"id":[{"id":"10.13039\/501100002790","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s00213-020-05573-1","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T08:02:36Z","timestamp":1593417756000},"page":"2795-2808","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The mTORC1 inhibitor rapamycin and the mTORC1\/2 inhibitor AZD2014 impair the consolidation and persistence of contextual fear memory"],"prefix":"10.1007","volume":"237","author":[{"given":"Phillip E.","family":"MacCallum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Blundell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,29]]},"reference":[{"issue":"2","key":"5573_CR1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0959-4388(00)00194-X","volume":"11","author":"T Abel","year":"2001","unstructured":"Abel T, Lattal KM (2001) Molecular mechanisms of memory acquisition, consolidation and retrieval. Curr Opin Neurobiol 11(2):180\u2013187","journal-title":"Curr Opin Neurobiol"},{"issue":"4","key":"5573_CR2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4161\/bioa.26497","volume":"3","author":"N Angliker","year":"2013","unstructured":"Angliker N, Ruegg MA (2013) In vivo evidence for mTORC2-mediated actin cytoskeleton rearrangement in neurons. Bioarchitecture 3(4):113\u2013118","journal-title":"Bioarchitecture"},{"key":"5573_CR3","first-page":"29","volume-title":"Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity","author":"MD Antion","year":"2008","unstructured":"Antion MD, Merhav M, Hoeffer CA, Reis G, Kozma SC, Thomas G, Schuman EM, Rosenblum K, Klann E (2008) Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity. Learning & Memory (Cold Spring Harbor, N.Y.), 15(1), 29\u201338"},{"issue":"7","key":"5573_CR4","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/gerona\/glw090","volume":"71","author":"SI Arriola Apelo","year":"2016","unstructured":"Arriola Apelo SI, Lamming DW (2016) Rapamycin: an InhibiTOR of aging emerges from the soil of Easter Island. J Gerontol A Biol Sci Med Sci 71(7):841\u2013849","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"1","key":"5573_CR5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/acel.12405","volume":"15","author":"SI Arriola Apelo","year":"2016","unstructured":"Arriola Apelo SI, Neuman JC, Baar EL, Syed FA, Cummings NE, Brar HK, Pumper CP, Kimple ME, Lamming DW (2016) Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system. Aging Cell 15(1):28\u201338","journal-title":"Aging Cell"},{"key":"5573_CR6","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/msb.2009.38","volume":"5","author":"N Aslam","year":"2009","unstructured":"Aslam N, Kubota Y, Wells D, Shouval HZ (2009) Translational switch for long-term maintenance of synaptic plasticity. Mol Syst Biol 5:284","journal-title":"Mol Syst Biol"},{"issue":"37","key":"5573_CR7","doi-asserted-by":"crossref","first-page":"12854","DOI":"10.1523\/JNEUROSCI.2024-12.2012","volume":"32","author":"AH Babayan","year":"2012","unstructured":"Babayan AH, Kramar EA, Barrett RM, Jafari M, Haettig J, Chen LY, Rex CS, Lauterborn JC, Wood MA, Gall CM, Lynch G (2012) Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation. J Neurosci 32(37):12854\u201312861","journal-title":"J Neurosci"},{"key":"5573_CR8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0079-6123(07)00004-0","volume":"169","author":"JL Banko","year":"2008","unstructured":"Banko JL, Klann E (2008) Cap-dependent translation initiation and memory. Prog Brain Res 169:59\u201380","journal-title":"Prog Brain Res"},{"issue":"15","key":"5573_CR9","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1158\/1078-0432.CCR-14-2422","volume":"21","author":"B Basu","year":"2015","unstructured":"Basu B, Dean E, Puglisi M, Greystoke A, Ong M, Burke W, Cavallin M, Bigley G, Womack C, Harrington EA, Green S, Oelmann E, de Bono JS, Ranson M, Banerji U (2015) First-in-human pharmacokinetic and pharmacodynamic study of the dual m-TORC 1\/2 inhibitor AZD2014. Clin Cancer Res 21(15):3412\u20133419","journal-title":"Clin Cancer Res"},{"issue":"2","key":"5573_CR10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.neuron.2006.11.025","volume":"53","author":"P Bekinschtein","year":"2007","unstructured":"Bekinschtein P, Cammarota M, Igaz LM, Bevilaqua LR, Izquierdo I, Medina JH (2007a) Persistence of long-term memory storage requires a late protein synthesis- and BDNF- dependent phase in the hippocampus. Neuron 53(2):261\u2013277","journal-title":"Neuron"},{"issue":"2","key":"5573_CR11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.nlm.2006.08.007","volume":"87","author":"P Bekinschtein","year":"2007","unstructured":"Bekinschtein P, Katche C, Slipczuk LN, Igaz LM, Cammarota M, Izquierdo I, Medina JH (2007b) mTOR signaling in the hippocampus is necessary for memory formation. Neurobiol Learn Mem 87(2):303\u2013307","journal-title":"Neurobiol Learn Mem"},{"issue":"7","key":"5573_CR12","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1073\/pnas.0711863105","volume":"105","author":"P Bekinschtein","year":"2008","unstructured":"Bekinschtein P, Cammarota M, Katche C, Slipczuk L, Rossato JI, Goldin A, Izquierdo I, Medina JH (2008) BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci U S A 105(7):2711\u20132716","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3\u20134","key":"5573_CR13","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s12640-010-9155-5","volume":"18","author":"P Bekinschtein","year":"2010","unstructured":"Bekinschtein P, Katche C, Slipczuk L, Gonzalez C, Dorman G, Cammarota M, Izquierdo I, Medina JH (2010) Persistence of long-term memory storage: new insights into its molecular signatures in the hippocampus and related structures. Neurotox Res 18(3\u20134):377\u2013385","journal-title":"Neurotox Res"},{"issue":"4","key":"5573_CR14","doi-asserted-by":"crossref","first-page":"e0176599","DOI":"10.1371\/journal.pone.0176599","volume":"12","author":"A Benavides-Serrato","year":"2017","unstructured":"Benavides-Serrato A, Lee J, Holmes B, Landon KA, Bashir T, Jung ME, Lichtenstein A, Gera J (2017) Specific blockade of rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma. PLoS One 12(4):e0176599","journal-title":"PLoS One"},{"issue":"2","key":"5573_CR15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.neuron.2012.07.022","volume":"76","author":"A Bhattacharya","year":"2012","unstructured":"Bhattacharya A, Kaphzan H, Alvarez-Dieppa AC, Murphy JP, Pierre P, Klann E (2012) Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice. Neuron 76(2):325\u2013337","journal-title":"Neuron"},{"issue":"1","key":"5573_CR16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.nlm.2007.12.004","volume":"90","author":"J Blundell","year":"2008","unstructured":"Blundell J, Kouser M, Powell CM (2008) Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation. Neurobiol Learn Mem 90(1):28\u201335","journal-title":"Neurobiol Learn Mem"},{"issue":"1","key":"5573_CR17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1067\/mcp.2001.112513","volume":"69","author":"Y Bottiger","year":"2001","unstructured":"Bottiger Y, Sawe J, Brattstrom C, Tollemar J, Burke JT, Hass G et al (2001) Pharmacokinetic interaction between single oral doses of diltiazem and sirolimus in healthy volunteers. Clin Pharmacol Ther 69(1):32\u201340","journal-title":"Clin Pharmacol Ther"},{"issue":"4\u20135","key":"5573_CR18","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1101\/lm.5.4.365","volume":"5","author":"R Bourtchouladze","year":"1998","unstructured":"Bourtchouladze R, Berman AN, Lapidus GK, Kandel ER (1998) Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA. Learn Mem 5(4\u20135):365\u2013374","journal-title":"Learn Mem"},{"key":"5573_CR19","doi-asserted-by":"crossref","first-page":"9560","DOI":"10.1523\/JNEUROSCI.2397-06.2006","volume":"26","author":"W Cai","year":"2006","unstructured":"Cai W, Blundell J, Han J, Greene RW, Powell CM (2006) Post-reactivation glucocorticoids impair recall of established fear memory. J Neurosci 26:9560\u20139566","journal-title":"J Neurosci"},{"issue":"45","key":"5573_CR20","doi-asserted-by":"crossref","first-page":"17414","DOI":"10.1073\/pnas.0809136105","volume":"105","author":"AY Choo","year":"2008","unstructured":"Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J (2008) Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. PNAS 105(45):17414\u201317419","journal-title":"PNAS"},{"key":"5573_CR21","volume-title":"Methods of behavior analysis in neuroscience","author":"P Curzon","year":"2009","unstructured":"Curzon P, Rustay NR, Browman KE (2009) Cued and contextual fear conditioning for rodents. In: Buccafusco JJ (ed) Methods of behavior analysis in neuroscience, 2nd edn. Taylor & Francis Group, Boca Raton","edition":"2"},{"issue":"31","key":"5573_CR22","doi-asserted-by":"crossref","first-page":"8048","DOI":"10.1523\/JNEUROSCI.0671-06.2006","volume":"26","author":"PK Dash","year":"2006","unstructured":"Dash PK, Orsi SA, Moore AN (2006) Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-mammalian target of rapamycin pathway. J Neurosci 26(31):8048\u20138056","journal-title":"J Neurosci"},{"issue":"3","key":"5573_CR23","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1037\/0033-2909.96.3.518","volume":"96","author":"HP Davis","year":"1984","unstructured":"Davis HP, Squire LR (1984) Protein synthesis and memory: a review. Psychol Bull 96(3):518\u2013559","journal-title":"Psychol Bull"},{"key":"5573_CR24","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.brainres.2008.07.123","volume":"1236","author":"B Desgranges","year":"2008","unstructured":"Desgranges B, L\u00e9vy F, Ferreira G (2008) Anisomycin infusion in amygdala impairs consolidation of odor aversion memory. Brain Res 1236:166\u2013175. https:\/\/doi.org\/10.1016\/j.brainres.2008.07.123","journal-title":"Brain Res"},{"issue":"5","key":"5573_CR25","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/epi.13345","volume":"57","author":"CM Drion","year":"2016","unstructured":"Drion CM, Borm LE, Kooijman L, Aronica E, Wadman WJ, Hartog AF, van Vliet EA, Gorter JA (2016) Effects of rapamycin and curcumin treatment on the development of epilepsy after electrically induced status epilepticus in rats. Epilepsia 57(5):688\u2013697","journal-title":"Epilepsia"},{"issue":"2","key":"5573_CR26","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1371\/journal.pbio.1000038","volume":"7","author":"ME Feldman","year":"2009","unstructured":"Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D et al (2009) Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 7(2):e38","journal-title":"PLoS Biol"},{"issue":"3768","key":"5573_CR27","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1126\/science.155.3768.1377","volume":"155","author":"LB Flexner","year":"1967","unstructured":"Flexner LB, Flexner JB, Roberts RB (1967) Memory in mice analyzed with antibiotics. Antibiotics are useful to study stages of memory and to indicate molecular events which sustain memory. Science 155(3768):1377\u20131383","journal-title":"Science"},{"issue":"3","key":"5573_CR28","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1006\/nlme.1995.1034","volume":"63","author":"FM Freeman","year":"1995","unstructured":"Freeman FM, Rose SP, Scholey AB (1995) Two time windows of Anisomycin-induced amnesia for passive avoidance training in the day-old chick. Neurobiol Learn Mem 63(3):291\u2013295. https:\/\/doi.org\/10.1006\/nlme.1995.1034","journal-title":"Neurobiol Learn Mem"},{"key":"5573_CR29","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.neuroscience.2011.03.023","volume":"182","author":"GM Gafford","year":"2011","unstructured":"Gafford GM, Parsons RG, Helmstetter FJ (2011) Consolidation and reconsolidation of contextual fear memory requires mammalian target of rapamycin-dependent translation in the dorsal hippocampus. Neuroscience 182:98\u2013104","journal-title":"Neuroscience"},{"issue":"11","key":"5573_CR30","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1101\/lm.1908310","volume":"17","author":"EM Glover","year":"2010","unstructured":"Glover EM, Ressler KJ, Davis M (2010) Differing effects of systemically administered rapamycin on consolidation and reconsolidation of context vs. cued fear memories. Learn Mem 17(11):577\u2013581","journal-title":"Learn Mem"},{"key":"5573_CR31","doi-asserted-by":"publisher","unstructured":"Grechsch G, Matthies H (1980) Two sensitive periods for the amnesic effect of anisomycin. Pharmacology, Biochemistry, and Behavior, 12(5):663\u20135. https:\/\/doi.org\/10.1016\/0091-3057(80)90145-8","DOI":"10.1016\/0091-3057(80)90145-8"},{"issue":"11","key":"5573_CR32","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1158\/1535-7163.MCT-15-0365","volume":"14","author":"SM Guichard","year":"2015","unstructured":"Guichard SM, Curwen J, Bihani T, D'Cruz CM, Yates JW, Grondine M et al (2015) AZD2014, an inhibitor of mTORC1 and mTORC2, is highly effective in ER+ breast cancer when administered using intermittent or continuous schedules. Mol Cancer Ther 14(11):2508\u20132518","journal-title":"Mol Cancer Ther"},{"issue":"3","key":"5573_CR33","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.nlm.2007.09.010","volume":"89","author":"PJ Hernandez","year":"2008","unstructured":"Hernandez PJ, Abel T (2008) The role of protein synthesis in memory consolidation: progress amid decades of debate. Neurobiol Learn Mem 89(3):293\u2013311","journal-title":"Neurobiol Learn Mem"},{"issue":"5","key":"5573_CR34","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.neuron.2008.09.037","volume":"60","author":"CA Hoeffer","year":"2008","unstructured":"Hoeffer CA, Tang W, Wong H, Santillan A, Patterson RJ, Martinez LA, Tejada-Simon MV, Paylor R, Hamilton SL, Klann E (2008) Removal of FKBP12 enhances mTOR-raptor interactions, LTP, memory, and perseverative\/repetitive behavior. Neuron 60(5):832\u2013845","journal-title":"Neuron"},{"issue":"6","key":"5573_CR35","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/00007691-199212000-00007","volume":"14","author":"N Honcharik","year":"1992","unstructured":"Honcharik N, Fryer J, Yatscoff R (1992) Pharmacokinetics of rapamycin: single-dose studies in the rabbit. Ther Drug Monit 14(6):475\u2013478","journal-title":"Ther Drug Monit"},{"issue":"4","key":"5573_CR36","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nn.3351","volume":"16","author":"W Huang","year":"2013","unstructured":"Huang W, Zhu PJ, Zhang S, Zhou H, Stoica L, Galiano M, Krnjevi\u0107 K, Roman G, Costa-Mattioli M (2013) mTORC2 controls actin polymerization required for consolidation of long-term memory. Nat Neurosci 16(4):441\u2013448","journal-title":"Nat Neurosci"},{"issue":"27","key":"5573_CR37","doi-asserted-by":"crossref","first-page":"9034","DOI":"10.1523\/JNEUROSCI.0878-14.2014","volume":"34","author":"TN Huynh","year":"2014","unstructured":"Huynh TN, Santini E, Klann E (2014) Requirement of mammalian target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence. J Neurosci 34(27):9034\u20139039","journal-title":"J Neurosci"},{"issue":"6","key":"5573_CR38","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/mp.2017.99","volume":"23","author":"TN Huynh","year":"2018","unstructured":"Huynh TN, Santini E, Mojica E, Fink AE, Hall BS, Fetcho RN, Grosenick L, Deisseroth K, LeDoux JE, Liston C, Klann E (2018) Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory. Mol Psychiatry 23(6):1394\u20131401","journal-title":"Mol Psychiatry"},{"key":"5573_CR39","doi-asserted-by":"publisher","unstructured":"Izquierdo I, McGaugh JL (2000) Behavioural pharmacology and its contribution to the molecular basis of memory consolidation. Behav Pharmacol 11(7\u20138):517\u2013534. https:\/\/doi.org\/10.1097\/00008877-200011000-00001","DOI":"10.1097\/00008877-200011000-00001"},{"issue":"9","key":"5573_CR40","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tins.2006.07.005","volume":"29","author":"I Izquierdo","year":"2006","unstructured":"Izquierdo I, Bevilaqua LR, Rossato JI, Bonini JS, Medina JH, Cammarota M (2006) Different molecular cascades in different sites of the brain control memory consolidation. Trends Neurosci 29(9):496\u2013505","journal-title":"Trends Neurosci"},{"key":"5573_CR41","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejphar.2016.05.013","volume":"784","author":"MH James","year":"2016","unstructured":"James MH, Quinn RK, Ong LK, Levi EM, Smith DW, Dickson PW, Dayas CV (2016) Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum. Eur J Pharmacol 784:147\u2013154","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"5573_CR42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.nlm.2011.10.002","volume":"97","author":"PF Jobim","year":"2012","unstructured":"Jobim PF, Pedroso TR, Christoff RR, Werenicz A, Maurmann N, Reolon GK et al (2012a) Inhibition of mTOR by rapamycin in the amygdala or hippocampus impairs formation and reconsolidation of inhibitory avoidance memory. Neurobiol Learn Mem 97(1):105\u2013112","journal-title":"Neurobiol Learn Mem"},{"issue":"1","key":"5573_CR43","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bbr.2011.12.004","volume":"228","author":"PF Jobim","year":"2012","unstructured":"Jobim PF, Pedroso TR, Werenicz A, Christoff RR, Maurmann N, Reolon GK et al (2012b) Impairment of object recognition memory by rapamycin inhibition of mTOR in the amygdala or hippocampus around the time of learning or reactivation. Behav Brain Res 228(1):151\u2013158","journal-title":"Behav Brain Res"},{"issue":"8","key":"5573_CR44","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.neo.2019.05.003","volume":"21","author":"AT Jones","year":"2019","unstructured":"Jones AT, Yang J, Narov K, Henske EP, Sampson JR, Shen MH (2019) Allosteric and ATP-competitive inhibitors of mTOR effectively suppress tumor progression-associated epithelial-mesenchymal transition in the kidneys of Tsc2+\/\u2212 mice. Neoplasia (New York, NY) 21(8):731\u2013739","journal-title":"Neoplasia (New York, NY)"},{"issue":"1","key":"5573_CR45","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/neuonc\/not139","volume":"16","author":"J Kahn","year":"2014","unstructured":"Kahn J, Hayman TJ, Jamal M, Rath BH, Kramp T, Camphausen K, Tofilon PJ (2014) The mTORC1\/mTORC2 inhibitor AZD2014 enhances the radiosensitivity of glioblastoma stem-like cells. Neuro Oncol 16(1):29\u201337","journal-title":"Neuro Oncol"},{"issue":"3","key":"5573_CR46","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0092-8674(04)00115-1","volume":"116","author":"RJ Kelleher 3rd","year":"2004","unstructured":"Kelleher RJ 3rd, Govindarajan A, Jung HY, Kang H, Tonegawa S (2004) Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell 116(3):467\u2013479","journal-title":"Cell"},{"issue":"5","key":"5573_CR47","doi-asserted-by":"crossref","first-page":"10.1101","DOI":"10.1101\/cshperspect.a025924","volume":"6","author":"DW Lamming","year":"2016","unstructured":"Lamming DW (2016) Inhibition of the mechanistic target of rapamycin (mTOR)-rapamycin and beyond. Cold Spring Harb Perspect Med 6(5):10.1101","journal-title":"Cold Spring Harb Perspect Med"},{"key":"5573_CR48","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.nlm.2016.11.006","volume":"137","author":"D Lana","year":"2017","unstructured":"Lana D, Di Russo J, Mello T, Wenk GL, Giovannini MG (2017) Rapamycin inhibits mTOR\/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory. Neurobiol Learn Mem 137:15\u201326","journal-title":"Neurobiol Learn Mem"},{"issue":"13","key":"5573_CR49","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1073\/pnas.0306546101","volume":"101","author":"KM Lattal","year":"2004","unstructured":"Lattal KM, Abel T (2004) Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time. PNAS 101(13):4667\u20134672","journal-title":"PNAS"},{"issue":"8","key":"5573_CR50","doi-asserted-by":"publisher","first-page":"1926","DOI":"10.1523\/JNEUROSCI.2966-17","volume":"38","author":"BPP Lay","year":"2018","unstructured":"Lay BPP, Westbrook RF, Glanzman DL, Holmes NM (2018) Commonalities and differences in the substrates underlying consolidation of first- and second-order conditioned fear. J Neurosci 38(8):1926\u20131941. https:\/\/doi.org\/10.1523\/JNEUROSCI.2966-17","journal-title":"J Neurosci"},{"key":"5573_CR51","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.nlm.2013.08.014","volume":"112","author":"PE MacCallum","year":"2014","unstructured":"MacCallum PE, Hebert M, Adamec RE, Blundell J (2014) Systemic inhibition of mTOR kinase via rapamycin disrupts consolidation and reconsolidation of auditory fear memory. Neurobiol Learn Mem 112:176\u2013185","journal-title":"Neurobiol Learn Mem"},{"key":"5573_CR52","doi-asserted-by":"publisher","unstructured":"Martinez-Moreno A, Rodriguez-Duran LF, Escobar ML (2011) Late rrotein synthesis-dependent phases in CTA long-term Memory: BDNF Requirement. Front Behav Neurosci 5:61. https:\/\/doi.org\/10.3389\/fnbeh.2011.00061. eCollection 2011","DOI":"10.3389\/fnbeh.2011.00061"},{"issue":"5451","key":"5573_CR53","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1126\/science.287.5451.248","volume":"287","author":"JL McGaugh","year":"2000","unstructured":"McGaugh JL (2000) Memory--a century of consolidation. Science. 287(5451):248\u2013251. https:\/\/doi.org\/10.1126\/science.287.5451.248","journal-title":"Science."},{"issue":"1","key":"5573_CR54","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/s0006-8993(97)01528-x","volume":"789","author":"N Meiri","year":"1998","unstructured":"Meiri N, Rosenblum K (1998) Lateral ventricle injection of the protein synthesis inhibitor Anisomycin impairs long-term memory in a spatial memory task. Brain Res 789(1):48\u201355. https:\/\/doi.org\/10.1016\/s0006-8993(97)01528-x","journal-title":"Brain Res"},{"issue":"7","key":"5573_CR55","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1101\/lm.598307","volume":"14","author":"MH Milekic","year":"2007","unstructured":"Milekic MH, Pollonini G, Alberini CM (2007) Temporal requirement of C\/EBPbeta in the amygdala following reactivation but not acquisition of inhibitory avoidance. Learn Mem 14(7):504\u2013511. https:\/\/doi.org\/10.1101\/lm.598307","journal-title":"Learn Mem"},{"issue":"12","key":"5573_CR56","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.18632\/aging.101346","volume":"9","author":"ER Murray","year":"2017","unstructured":"Murray ER, Cameron AJM (2017) Towards specific inhibition of mTORC2. Aging 9(12):2461\u20132462","journal-title":"Aging"},{"issue":"3","key":"5573_CR57","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.nlm.2007.10.002","volume":"89","author":"JC Myskiw","year":"2008","unstructured":"Myskiw JC, Rossato JI, Bevilaqua LR, Medina JH, Izquierdo I, Cammarota M (2008) On the participation of mTOR in recognition memory. Neurobiol Learn Mem 89(3):338\u2013351","journal-title":"Neurobiol Learn Mem"},{"issue":"2","key":"5573_CR58","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/jnc.12725","volume":"130","author":"J Neasta","year":"2014","unstructured":"Neasta J, Barak S, Hamida SB, Ron D (2014) mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse. J Neurochem 130(2):172\u2013184","journal-title":"J Neurochem"},{"issue":"50","key":"5573_CR59","doi-asserted-by":"crossref","first-page":"12977","DOI":"10.1523\/JNEUROSCI.4209-06.2006","volume":"26","author":"RG Parsons","year":"2006","unstructured":"Parsons RG, Gafford GM, Helmstetter FJ (2006) Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons. J Neurosci 26(50):12977\u201312983","journal-title":"J Neurosci"},{"issue":"2","key":"5573_CR60","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1042\/BJ20101024","volume":"431","author":"LR Pearce","year":"2010","unstructured":"Pearce LR, Alton GR, Richter DT, Kath JC, Lingardo L, Chapman J, Hwang C, Alessi DR (2010) Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J 431(2):245\u2013255","journal-title":"Biochem J"},{"key":"5573_CR61","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.brainresbull.2014.10.009","volume":"109","author":"RR Pena","year":"2014","unstructured":"Pena RR, Pereira-Caixeta AR, Moraes MF, Pereira GS (2014) Anisomycin administered in the olfactory bulb and dorsal hippocampus impaired social recognition memory consolidation in different time-points. Brain Res Bull 109:151\u2013157","journal-title":"Brain Res Bull"},{"issue":"3","key":"5573_CR62","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.eururo.2015.08.035","volume":"69","author":"T Powles","year":"2016","unstructured":"Powles T, Wheater M, Din O, Geldart T, Boleti E, Stockdale A, Sundar S, Robinson A, Ahmed I, Wimalasingham A, Burke W, Sarker SJ, Hussain S, Ralph C (2016) A randomised phase 2 study of AZD2014 versus everolimus in patients with VEGF-refractory metastatic clear cell renal cancer. Eur Urol 69(3):450\u2013456","journal-title":"Eur Urol"},{"issue":"6","key":"5573_CR63","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1101\/lm.6.6.600","volume":"6","author":"J Quevedo","year":"1999","unstructured":"Quevedo J, Vianna MR, Roesler R, de Paris F, Izquierdo I, Rose SP (1999) Two time windows of anisomycin-induced amnesia for inhibitory avoidance training in rats: protection from amnesia by pretraining but not pre-exposure to the task apparatus. Learn Mem 6(6):600\u2013607","journal-title":"Learn Mem"},{"key":"5573_CR64","volume-title":"Neural plasticity and memory: from genes to brain imaging","author":"CJ Rodriguez-Ortiz","year":"2007","unstructured":"Rodriguez-Ortiz CJ, Bermudez-Rattoni F (2007) Memory reconsolidation or updating consolidation? In: Bermudez-Rattoni F (ed) Neural plasticity and memory: from genes to brain imaging. Boca Raton, Taylor & Francis Group"},{"issue":"1","key":"5573_CR65","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1101\/lm.422607","volume":"14","author":"JI Rossato","year":"2007","unstructured":"Rossato JI, Bevilaqua LR, Myskiw JC, Medina JH, Izquierdo I, Cammarota M (2007) On the role of hippocampal protein synthesis in the consolidation and reconsolidation of object recognition memory. Learn Mem 14(1):36\u201346","journal-title":"Learn Mem"},{"issue":"6238","key":"5573_CR66","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1126\/science.aaa5542","volume":"348","author":"TJ Ryan","year":"2015","unstructured":"Ryan TJ, Roy DS, Pignatelli M, Arons A, Tonegawa S (2015) Memory. Engram cells retain memory under retrograde amnesia. Science 348(6238):1007\u20131013. https:\/\/doi.org\/10.1126\/science.aaa5542","journal-title":"Science"},{"issue":"45","key":"5573_CR67","doi-asserted-by":"crossref","first-page":"11818","DOI":"10.1073\/pnas.1716173114","volume":"114","author":"DM Sabatini","year":"2017","unstructured":"Sabatini DM (2017) Twenty-five years of mTOR: uncovering the link from nutrients to growth. PNAS 114(45):11818\u201311825","journal-title":"PNAS"},{"issue":"2","key":"5573_CR68","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.molcel.2006.03.029","volume":"22","author":"DD Sarbassov","year":"2006","unstructured":"Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, Markhard AL, Sabatini DM (2006) Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt\/PKB. Mol Cell 22(2):159\u2013168","journal-title":"Mol Cell"},{"issue":"2","key":"5573_CR69","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cell.2017.03.035","volume":"169","author":"RA Saxton","year":"2017","unstructured":"Saxton RA, Sabatini DM (2017) mTOR signaling in growth, metabolism, and disease. Cell 169(2):361\u2013371","journal-title":"Cell"},{"issue":"2","key":"5573_CR70","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.molcel.2010.09.026","volume":"40","author":"S Sengupta","year":"2010","unstructured":"Sengupta S, Peterson TR, Sabatini DM (2010) Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 40(2):310\u2013322","journal-title":"Mol Cell"},{"issue":"6","key":"5573_CR71","doi-asserted-by":"crossref","first-page":"e6007","DOI":"10.1371\/journal.pone.0006007","volume":"4","author":"L Slipczuk","year":"2009","unstructured":"Slipczuk L, Bekinschtein P, Katche C, Cammarota M, Izquierdo I, Medina JH (2009) BDNF activates mTOR to regulate GluR1 expression required for memory formation. PLoS One 4(6):e6007","journal-title":"PLoS One"},{"key":"5573_CR72","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(07)00001-5","volume":"169","author":"WS Sossin","year":"2008","unstructured":"Sossin WS (2008) Molecular memory traces. Prog Brain Res 169:3\u201325","journal-title":"Prog Brain Res"},{"issue":"9","key":"5573_CR73","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1073\/pnas.1014715108","volume":"108","author":"L Stoica","year":"2011","unstructured":"Stoica L, Zhu PJ, Huang W, Zhou H, Kozma SC, Costa-Mattioli M (2011) Selective pharmacogenetic inhibition of mammalian target of rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage. PNAS 108(9):3791\u20133796","journal-title":"PNAS"},{"issue":"10","key":"5573_CR74","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1101\/lm.1067808","volume":"15","author":"L Sui","year":"2008","unstructured":"Sui L, Wang J, Li BM (2008) Role of the phosphoinositide 3-kinase-akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex. Learn Mem 15(10):762\u2013776","journal-title":"Learn Mem"},{"key":"5573_CR75","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbr.2019.02.014","volume":"364","author":"T Sun","year":"2019","unstructured":"Sun T, Liu Z, Liu M, Guo Y, Sun H, Zhao J, Lan Z, Lian B, Zhang J (2019) Hippocampus-specific rictor knockdown inhibited 17beta-estradiol induced neuronal plasticity and spatial memory improvement in ovariectomized mice. Behav Brain Res 364:50\u201361","journal-title":"Behav Brain Res"},{"issue":"4","key":"5573_CR76","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF00685908","volume":"33","author":"JG Supko","year":"1994","unstructured":"Supko JG, Malspeis L (1994) Dose-dependent pharmacokinetics of rapamycin-28-N,N-dimethylglycinate in the mouse. Cancer Chemother Pharmacol 33(4):325\u2013330","journal-title":"Cancer Chemother Pharmacol"},{"issue":"5","key":"5573_CR77","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1158\/2159-8290.CD-17-0699","volume":"8","author":"JLF Teh","year":"2018","unstructured":"Teh JLF, Cheng PF, Purwin TJ, Nikbakht N, Patel P, Chervoneva I, Ertel A, Fortina PM, Kleiber I, HooKim K, Davies MA, Kwong LN, Levesque MP, Dummer R, Aplin AE (2018) In vivo E2F reporting reveals efficacious schedules of MEK1\/2-CDK4\/6 targeting and mTOR-S6 resistance mechanisms. Cancer Discov 8(5):568\u2013581","journal-title":"Cancer Discov"},{"issue":"12","key":"5573_CR78","doi-asserted-by":"crossref","first-page":"8023","DOI":"10.1074\/jbc.M900301200","volume":"284","author":"CC Thoreen","year":"2009","unstructured":"Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, Reichling LJ, Sim T, Sabatini DM, Gray NS (2009) An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 284(12):8023\u20138032","journal-title":"J Biol Chem"},{"key":"5573_CR79","doi-asserted-by":"publisher","unstructured":"Wanisch K, Wotjak CT, Engelmann M (2008) Long-lasting second stage of recognition memory consolidation in mice. Behav Brain Res 186(2):191\u2013196. https:\/\/doi.org\/10.1016\/j.bbr.2007.08.008","DOI":"10.1016\/j.bbr.2007.08.008"},{"issue":"7","key":"5573_CR80","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1158\/0008-5472.CAN-17-2388","volume":"78","author":"TA Werfel","year":"2018","unstructured":"Werfel TA, Wang S, Jackson MA, Kavanaugh TE, Joly MM, Lee LH, Hicks DJ, Sanchez V, Ericsson PG, Kilchrist KV, Dimobi SC, Sarett SM, Brantley-Sieders DM, Cook RS, Duvall CL (2018) Selective mTORC2 inhibitor therapeutically blocks breast cancer cell growth and survival. Cancer Res 78(7):1845\u20131858","journal-title":"Cancer Res"},{"issue":"15","key":"5573_CR81","doi-asserted-by":"crossref","first-page":"6232","DOI":"10.1158\/0008-5472.CAN-09-0299","volume":"69","author":"K Yu","year":"2009","unstructured":"Yu K, Toral-Barza L, Shi C, Zhang WG, Lucas J, Shor B, Kim J, Verheijen J, Curran K, Malwitz DJ, Cole DC, Ellingboe J, Ayral-Kaloustian S, Mansour TS, Gibbons JJ, Abraham RT, Nowak P, Zask A (2009) Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. Cancer Res 69(15):6232\u20136240","journal-title":"Cancer Res"},{"issue":"1","key":"5573_CR82","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1038\/s41467-019-12436-7","volume":"10","author":"B Zhao","year":"2019","unstructured":"Zhao B, Sun J, Zhang X, Mo H, Niu Y, Li Q, Wang L, Zhong Y (2019) Long-term memory is formed immediately without the need for protein synthesis-dependent consolidation in drosophila. Nat Commun 10(1):4550","journal-title":"Nat Commun"},{"issue":"11","key":"5573_CR83","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.1158\/1535-7163.MCT-14-0144","volume":"13","author":"H Zhong","year":"2014","unstructured":"Zhong H, Fazenbaker C, Breen S, Chen C, Huang J, Morehouse C, Yao Y, Hollingsworth RE (2014) MEDI-573, alone or in combination with mammalian target of rapamycin inhibitors, targets the insulin-like growth factor pathway in sarcomas. Mol Cancer Ther 13(11):2662\u20132673","journal-title":"Mol Cancer Ther"},{"issue":"6","key":"5573_CR84","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41593-018-0156-7","volume":"21","author":"PJ Zhu","year":"2018","unstructured":"Zhu PJ, Chen CJ, Mays J, Stoica L, Costa-Mattioli M (2018) mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors. Nat Neurosci 21(6):799\u2013802","journal-title":"Nat Neurosci"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-020-05573-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-020-05573-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-020-05573-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T18:55:37Z","timestamp":1667156137000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-020-05573-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,29]]},"references-count":84,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["5573"],"URL":"https:\/\/doi.org\/10.1007\/s00213-020-05573-1","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,29]]},"assertion":[{"value":"26 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}