{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:33:20Z","timestamp":1792679600994,"version":"4.5.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:00:00Z","timestamp":1596844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:00:00Z","timestamp":1596844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R15DA046926"],"award-info":[{"award-number":["R15DA046926"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s00213-020-05631-8","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T20:02:27Z","timestamp":1596916947000},"page":"3519-3527","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The adenosine A(2A) receptor agonist CGS 21680 alleviates auditory sensorimotor gating deficits and increases in accumbal CREB in rats neonatally treated with quinpirole"],"prefix":"10.1007","volume":"237","author":[{"given":"Russell W.","family":"Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep G.","family":"Bhide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Drew","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren D.","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,8]]},"reference":[{"key":"5631_CR1","doi-asserted-by":"crossref","unstructured":"Adler LE, Freedman R, Ross RG, Olincy A, Waldo MC (1999) Elementary phenotypes in the neurobiological and genetic study of schizophrenia. Biol Psychiatry 46:8\u201318","DOI":"10.1016\/S0006-3223(99)00085-2"},{"key":"5631_CR2","doi-asserted-by":"crossref","first-page":"11435","DOI":"10.1073\/pnas.172091899","volume":"99","author":"M Barrot","year":"2002","unstructured":"Barrot M, Olivier JD, Perrotti LI, DiLeone RJ, Berton O, Eisch AJ, Impey S, Storm DR, Neve RL, Yin JC, Zachariou V, Nestler EJ (2002) CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc Natl Acad Sci U S A 99:11435\u201311440","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5631_CR3","doi-asserted-by":"crossref","first-page":"8357","DOI":"10.1073\/pnas.0500587102","volume":"102","author":"M Barrot","year":"2005","unstructured":"Barrot M, Wallace-Black D, Bolanos CA, Graham D, Perrotti LI, Neve RL, Chambliss H, Yin JC, Nestler EJ (2005) Regulation of anxiety and initiation of sexual anxiety by CREB in the nucleus accumbens. Proc Natl Acad Sci U S A 102:8357\u20138362","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5631_CR4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pneurobio.2013.10.005","volume":"112","author":"MR Bennett","year":"2014","unstructured":"Bennett MR, Lagopoulos J (2014) Stress and trauma: BDNF control of dendritic-spine formation and regression. Prog Neurobiol 112:80\u201399","journal-title":"Prog Neurobiol"},{"key":"5631_CR5","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.biopsych.2010.08.032","volume":"69","author":"AK Berger","year":"2011","unstructured":"Berger AK, Green T, Siegel SJ, Nestler EJ, Hammer RP Jr (2011) cAMP response element binding protein phosphorylation in nucleus accumbens underlies sustained recovery of sensorimotor gating following repeated D2-like receptor agonist treatment in rats. Biol Psychiatry 69:288\u2013294","journal-title":"Biol Psychiatry"},{"key":"5631_CR6","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.biopsych.2005.11.003","volume":"59","author":"JA Blendy","year":"2006","unstructured":"Blendy JA (2006) The role of CREB in depression and antidepressant treatment. Biol Psychiatry 59:1144\u20131150","journal-title":"Biol Psychiatry"},{"key":"5631_CR7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.coph.2007.09.002","volume":"8","author":"D Boison","year":"2008","unstructured":"Boison D (2008) Adenosine as a neuromodulator in neurological diseases. Curr Opin Pharmacol 8:2\u20137","journal-title":"Curr Opin Pharmacol"},{"key":"5631_CR8","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/cdd.2009.131","volume":"17","author":"D Boison","year":"2010","unstructured":"Boison D, Chen JF, Fredholm BB (2010) Adenosine signalling and function in glial cells. Cell Death Differ 17:1071\u20131082","journal-title":"Cell Death Differ"},{"key":"5631_CR9","doi-asserted-by":"crossref","unstructured":"Brown RW, Maple AM, Perna MK, Sheppard AB, Cope ZA, Kostrzewa RM (2012) Schizophrenia and substance abuse comorbidity: nicotine addiction and the neonatal quinpirole model. Dev Neurosci 34:140\u201351","DOI":"10.1159\/000338830"},{"key":"5631_CR10","doi-asserted-by":"crossref","unstructured":"Carlezon Jr, WA, Thome J, Olson VG, Lane-Ladd SB, Brodkin ES, Hiroi N, Duman RS, Neve RL, Nestler EJ. (1998) Regulation of cocaine reward by CREB Science, 282:2272\u20132275","DOI":"10.1126\/science.282.5397.2272"},{"key":"5631_CR11","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.tins.2005.06.005","volume":"28","author":"WA Carlezon Jr","year":"2005","unstructured":"Carlezon WA Jr, Duman RS, Nestler EJ (2005) The many faces of CREB. Trends Neurosci 28:436\u2013445","journal-title":"Trends Neurosci"},{"key":"5631_CR12","doi-asserted-by":"crossref","unstructured":"Chouinard G, Samaha AN, Chouinard VA, Peretti CS, Kanahara N, Takase M, Iyo M (2017) Antipsychotic-Induced Dopamine Supersensitivity Psychosis: Pharmacology, Criteria, and Therapy. Psychother Psychosom 86:189\u2013219","DOI":"10.1159\/000477313"},{"key":"5631_CR13","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1038\/sj.npp.1300483","volume":"29","author":"KE Culm","year":"2004","unstructured":"Culm KE, Lugo-Escobar N, Hope BT, Hammer RP Jr (2004) Repeated quinpirole treatment increases cAMP-dependent protein kinase activity and CREB phosphorylation in nucleus accumbens and reverses quinpirole-induced sensorimotor gating deficits in rats. Neuropsychopharmacology. 29:1823\u20131830","journal-title":"Neuropsychopharmacology."},{"key":"5631_CR14","doi-asserted-by":"crossref","unstructured":"Dinieri JA, Nemeth CL, Parsegian A, Carle T, Gurevich VV, Gurevich E, Neve RL, Nestler EJ, Carlezon WA Jr (2009) Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens. J Neurosci 29:1855\u20139","DOI":"10.1523\/JNEUROSCI.5104-08.2009"},{"key":"5631_CR15","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1345\/aph.18215","volume":"33","author":"DA Dixon","year":"1999","unstructured":"Dixon DA, Fenix LA, Kim DM, Raffa RB (1999) Indirect modulation of dopamine D2 receptors as potential pharmacotherapy for schizophrenia: I. Adenosine agonists. Ann Pharmacother 33:480\u2013488","journal-title":"Ann Pharmacother"},{"key":"5631_CR16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1017\/S109285290001004X","volume":"10","author":"D Eilam","year":"2005","unstructured":"Eilam D, Szechtman H (2005) Psychostimulant-induced behavior as an animal model of obsessive-compulsive disorder: an ethological approach to the form of compulsive rituals. CNS Spectr 10:191\u2013202","journal-title":"CNS Spectr"},{"key":"5631_CR17","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2174\/092986712803414231","volume":"19","author":"M Filip","year":"2012","unstructured":"Filip M, Zaniewska M, Frankowska M, Wydra K, Fuxe K (2012) The importance of the adenosine A(2A) receptor-dopamine D(2) receptor interaction in drug addiction. Curr Med Chem 19:317\u2013355","journal-title":"Curr Med Chem"},{"key":"5631_CR18","first-page":"527","volume":"53","author":"BB Fredholm","year":"2001","unstructured":"Fredholm BB, Jacobson KA, Klotz KN, Linden J (2001) International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53:527\u2013552","journal-title":"Pharmacol Rev"},{"key":"5631_CR19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.31887\/DCNS.2006.8.1\/mgeyer","volume":"8","author":"MA Geyer","year":"2006","unstructured":"Geyer MA (2006) Are cross-species measures of sensorimotor gating useful for the discovery of procognitive cotreatments for schizophrenia? Dialogues Clin Neurosci 8:9\u201316","journal-title":"Dialogues Clin Neurosci"},{"key":"5631_CR20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s002130100811","volume":"156","author":"MA Geyer","year":"2001","unstructured":"Geyer MA, Krebs-Thomson K, Braff DL, Swerdlow NR (2001) Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology 156:117\u2013154","journal-title":"Psychopharmacology"},{"issue":"1","key":"5631_CR21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/0269881119885917","volume":"34","author":"WD Gill","year":"2020","unstructured":"Gill WD, Shelton HW, Burgess KC, Brown RW (2020) Effects of an adenosine A(2A) agonist on the rewarding associative properties of nicotine and neural plasticity in a rodent model of schizophrenia. J Psychopharmacol 34(1):137\u2013144","journal-title":"J Psychopharmacol"},{"key":"5631_CR22","doi-asserted-by":"crossref","unstructured":"Gogos A, Kusljic S, Thwaites SJ, van den Buuse M (2017) Sex differences in psychotomimetic-induced behaviours in rats. Behav Brain Res (Pt A):322, 157\u2013166","DOI":"10.1016\/j.bbr.2017.01.028"},{"key":"5631_CR23","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1016\/S0028-3908(00)00024-1","volume":"39","author":"K Go\u0142embiowska","year":"2000","unstructured":"Go\u0142embiowska K, Zylewska A (2000) Effect of adenosine kinase, adenosine deaminase and transport inhibitors on striatal dopamine and stereotypy after methamphetamine administration. Neuropharmacology 39:2124\u20132132","journal-title":"Neuropharmacology"},{"issue":"10","key":"5631_CR24","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.biopsych.2008.06.016","volume":"64","author":"SL Gourley","year":"2008","unstructured":"Gourley SL, Kiraly DD, Howell JL, Olausson P, Taylor JR (2008) Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosterone. Biol Psychiatry 64(10):884\u2013890","journal-title":"Biol Psychiatry"},{"key":"5631_CR25","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s12640-010-9154-6","volume":"18","author":"AA Grace","year":"2010","unstructured":"Grace AA (2010) Dopamine system dysregulation by the ventral subiculum as the common pathophysiological basis for schizophrenia psychosis, psychostimulant abuse, and stress. Neurotox Res 18:367\u2013376","journal-title":"Neurotox Res"},{"key":"5631_CR26","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1097\/00001756-199704140-00038","volume":"8","author":"W Hauber","year":"1997","unstructured":"Hauber W, Koch M (1997) Adenosine A2a receptors in the nucleus accumbens modulate prepulse inhibition of the startle response. Neuroreport. 8:1515\u20131518","journal-title":"Neuroreport."},{"key":"5631_CR27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0304-3940(92)90905-M","volume":"141","author":"CA Janusz","year":"1992","unstructured":"Janusz CA, Berman RF (1992) The A2-selective adenosine analog, CGS 21680, depresses locomotor activity but does not block amygdala kindled seizures in rats. Neurosci Lett 141:247\u2013250","journal-title":"Neurosci Lett"},{"key":"5631_CR28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.neuropharm.2014.03.002","volume":"81","author":"J Jastrz\u0119bska","year":"2014","unstructured":"Jastrz\u0119bska J, Nowak E, Smaga I, Bystrowska B, Frankowska M, Bader M, Filip M, Fuxe K (2014) Adenosine (A)(2A)receptor modulation of nicotine-induced locomotor sensitization. A pharmacological and transgenic approach. Neuropharmacology 81:318\u2013326","journal-title":"Neuropharmacology"},{"key":"5631_CR29","unstructured":"Javitt DC, Freedman R (2015) Sensory processing dysfunction in the personal experience and neuronal machinery of schizophrenia. Am J Psychiatry:17217\u201317231"},{"key":"5631_CR30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/B978-0-7020-5307-8.00007-7","volume":"62","author":"M Koch","year":"2013","unstructured":"Koch M (2013) Clinical relevance of animal models of schizophrenia. Suppl Clin Neurophysiol 62:113\u2013120","journal-title":"Suppl Clin Neurophysiol"},{"key":"5631_CR31","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1124\/jpet.118.247981","volume":"366","author":"RM Kostrzewa","year":"2018","unstructured":"Kostrzewa RM, Wydra K, Filip M, Crawford CA, McDougall SA, Brown RW, Borroto-Escuela DO, Fuxe K, Gainetdinov RR (2018) Dopamine D(2) receptor supersensitivity as a spectrum of neurotoxicity and status in psychiatric disorders. J Pharmacol Exp Ther 366:519\u2013526","journal-title":"J Pharmacol Exp Ther"},{"key":"5631_CR32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchemneu.2017.10.005","volume":"88","author":"P Kowia\u0144ski","year":"2018","unstructured":"Kowia\u0144ski P, Lietzau G, Steliga A, Czuba E, Ludkiewicz B, Wa\u015bkow M, Spodnik JH, Mory\u015b J (2018) Nicotine-induced CREB and DeltaFosB activity is modified by caffeine in the brain reward system of the rat. J Chem Neuroanat 88:1\u201312","journal-title":"J Chem Neuroanat"},{"key":"5631_CR33","doi-asserted-by":"crossref","first-page":"112053","DOI":"10.1016\/j.bbr.2019.112053","volume":"372","author":"Q Lu","year":"2019","unstructured":"Lu Q, Mouri A, Yang Y, Kunisawa K, Teshigawara T, Hirakawa M, Mori Y, Yamamoto Y, Libo Z, Nabeshima T, Saito K (2019) Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression. Behav Brain Res 372:112053","journal-title":"Behav Brain Res"},{"key":"5631_CR34","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0301-0511(03)00074-7","volume":"63","author":"K Ludewig","year":"2003","unstructured":"Ludewig K, Ludewig S, Seitz A, Obrist M, Geyer MA, Vollenweider FX (2003) The acoustic startle reflex and its modulation: effects of age and gender in humans. Biol Psychol 63:311\u2013323","journal-title":"Biol Psychol"},{"key":"5631_CR35","doi-asserted-by":"crossref","unstructured":"M\u00e4ki P, Veijola J, Jones PB, Murray GK, Koponen H, Tienari P, Miettunen J, Tanskanen P, Wahlberg KE, Koskinen J, Lauronen E, Isohanni M (2005) Predictors of schizophrenia--a review. Br Med Bull 73\u201374:1\u201315","DOI":"10.1093\/bmb\/ldh046"},{"key":"5631_CR36","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1111\/j.1460-9568.2007.05860.x","volume":"26","author":"AM Maple","year":"2007","unstructured":"Maple AM, Perna MK, Parlaman JP, Stanwood GD, Brown RW (2007) Ontogenetic quinpirole treatment produces long-lasting decreases in the expression of Rgs9, but increases Rgs17 in the striatum, nucleus accumbens and frontal cortex. Eur J Neurosci 26:2532\u20132538","journal-title":"Eur J Neurosci"},{"key":"5631_CR37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.pbb.2015.08.011","volume":"137","author":"AM Maple","year":"2015","unstructured":"Maple AM, Smith KJ, Perna MK, Brown RW (2015) Neonatal quinpirole treatment produces prepulse inhibition deficits in adult male and female rats. Pharmacol Biochem Behav 137:93\u2013100","journal-title":"Pharmacol Biochem Behav"},{"key":"5631_CR38","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0091-3057(93)90146-K","volume":"45","author":"GE Martin","year":"1993","unstructured":"Martin GE, Rossi DJ, Jarvis MF (1993) Adenosine agonists reduce conditioned avoidance responding in the rat. Pharmacol Biochem Behav 45:951\u2013958","journal-title":"Pharmacol Biochem Behav"},{"key":"5631_CR39","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bbr.2017.04.057","volume":"331","author":"AS Monte","year":"2017","unstructured":"Monte AS, Mello BSF, Borella VCM, da Silva AT, da Silva FER, Sousa FCF, de Oliveira ACP, Gama CS, Seeman MV, Vasconcelos SMM, Lucena DF, Mac\u00eado D (2017) Two-hit model of schizophrenia induced by neonatal immune activation and peripubertal stress in rats: study of sex differences and brain oxidative alterations. Behav Brain Res 331:30\u201337","journal-title":"Behav Brain Res"},{"key":"5631_CR40","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/dev.21366","volume":"58","author":"LM Moran","year":"2016","unstructured":"Moran LM, Hord LL, Booze RM, Harrod SB, Mactutus CF (2016) The role of sensory modality in prepulse inhibition: an ontogenetic study. Dev Psychobiol 58:211\u2013222","journal-title":"Dev Psychobiol"},{"key":"5631_CR41","doi-asserted-by":"crossref","unstructured":"Nestler EJ (2015) Role of the Brain's Reward Circuitry in Depression: Transcriptional Mechanisms. Int Rev Neurobiol. 124:151\u201370","DOI":"10.1016\/bs.irn.2015.07.003"},{"key":"5631_CR42","doi-asserted-by":"crossref","unstructured":"Nestler EJ, Carlezon WA Jr (2006) The mesolimbic dopamine reward circuit in depression. Biol Psychiatry 59:1151\u20139","DOI":"10.1016\/j.biopsych.2005.09.018"},{"key":"5631_CR43","first-page":"994","volume":"20","author":"GA Ordway","year":"2017","unstructured":"Ordway GA, Szebeni A, Hernandez LJ, Crawford JD, Szebeni K, Chandley MJ, Burgess KC, Miller C, Bakkalbasi E, Brown RW (2017) Antidepressant-like actions of inhibitors of poly(ADP-ribose) polymerase in rodent models. Int J Neuropsychopharmacol 20:994\u20131004","journal-title":"Int J Neuropsychopharmacol"},{"key":"5631_CR44","doi-asserted-by":"crossref","unstructured":"Ren X, Rizavi HS, Khan MA, Bhaumik R, Dwivedi Y, Pandey GN (2014) Alteration of cyclic-AMP response element binding protein in the postmortem brain of subjects with bipolar disorder and schizophrenia. J Affect Disord. 152\u2013154:326\u201333","DOI":"10.1016\/j.jad.2013.09.033"},{"key":"5631_CR45","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1007\/s12035-017-0696-y","volume":"55","author":"K Sahlholm","year":"2018","unstructured":"Sahlholm K, G\u00f3mez-Soler M, Valle-Le\u00f3n M, L\u00f3pez-Cano M, Taura JJ, Ciruela F, Fern\u00e1ndez-Due\u00f1as V (2018) Antipsychotic-like efficacy of dopamine D(2) receptor-biased ligands is dependent on adenosine A(2A) receptor expression. Mol Neurobiol 55:4952\u20134958","journal-title":"Mol Neurobiol"},{"key":"5631_CR46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2010.07080.x","volume":"116","author":"K Sakamoto","year":"2011","unstructured":"Sakamoto K, Karelina K, Obrietan K (2011) CREB: a multifaceted regulator of neuronal plasticity and protection. J Neurochem 116:1\u20139","journal-title":"J Neurochem"},{"key":"5631_CR47","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1523\/JNEUROSCI.18-05-01848.1998","volume":"18","author":"DW Self","year":"1998","unstructured":"Self DW, Genova LM, Hope BT, Barnhart WJ, Spencer JJ, Nestler EJ (1998) Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. J Neurosci 18:1848\u20131859","journal-title":"J Neurosci"},{"issue":"2\u20133","key":"5631_CR48","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s002130100777","volume":"156","author":"TL Sills","year":"2001","unstructured":"Sills TL, Azampanah A, Fletcher PJ (2001) The adenosine A2A agonist CGS 21680 reverses the reduction in prepulse inhibition of the acoustic startle response induced by phencyclidine, but not by apomorphine and amphetamine. Psychopharmacology 156(2\u20133):187\u2013193","journal-title":"Psychopharmacology"},{"key":"5631_CR49","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s00213-006-0595-9","volume":"191","author":"H Sotoyama","year":"2007","unstructured":"Sotoyama H, Namba H, Takei N, Nawa H (2007) Neonatal exposure to epidermal growth factor induces dopamine D2-like receptor supersensitivity in adult sensorimotor gating. Psychopharmacology 191:783\u2013792","journal-title":"Psychopharmacology"},{"key":"5631_CR50","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0006-8993(92)90670-5","volume":"571","author":"S Subramaniam","year":"1992","unstructured":"Subramaniam S, Lucki I, McGonigle P (1992) Effects of chronic treatment with selective agonists on the subtypes of dopamine receptors. Brain Res 571:313\u2013322","journal-title":"Brain Res"},{"key":"5631_CR51","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1126\/science.1089681","volume":"302","author":"P Svenningsson","year":"2003","unstructured":"Svenningsson P, Tzavara ET, Carruthers R, Rachleff I, Wattler S, Nehls M, McKinzie DL, Fienberg AA, Nomikos GG, Greengard P (2003) Diverse psychotomimetics act through a common signaling pathway. Science. 302:1412\u20131415","journal-title":"Science."},{"key":"5631_CR52","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1177\/0269881116661075","volume":"30","author":"NR Swerdlow","year":"2016","unstructured":"Swerdlow NR, Braff DL, Geyer MA (2016) Sensorimotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next. J Psychopharmacol 30:1072\u20131081","journal-title":"J Psychopharmacol"},{"key":"5631_CR53","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fpsyg.2016.00206","volume":"7","author":"JP Vargas","year":"2016","unstructured":"Vargas JP, D\u00edaz E, Portavella M, L\u00f3pez JC (2016) Animal models of maladaptive traits: disorders in sensorimotor gating and attentional quantifiable responses as possible endophenotypes. Front Psychol 7:206","journal-title":"Front Psychol"},{"key":"5631_CR54","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.brainres.2004.11.013","volume":"1032","author":"CL Walters","year":"2005","unstructured":"Walters CL, Godfrey M, Li X, Blendy JA (2005) Alterations in morphine-induced reward, locomotor activity, and thermoregulation in CREB-deficient mice. Brain Res 1032:193\u2013199","journal-title":"Brain Res"},{"key":"5631_CR55","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00213-003-1439-5","volume":"168","author":"J Wardas","year":"2003","unstructured":"Wardas J, Konieczny J, Pietraszek M (2003) Influence of CGS 21680, a selective adenosine A(2A) agonist, on the phencyclidine-induced sensorimotor gating deficit and motor behaviour in rats. Psychopharmacology 168:299\u2013306","journal-title":"Psychopharmacology"},{"key":"5631_CR56","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1212\/01.WNL.0000095221.30476.8A","volume":"61","author":"SM Weiss","year":"2003","unstructured":"Weiss SM, Whawell E, Upton R, Dourish CT (2003) Potential for antipsychotic and psychotomimetic effects of A2A receptor modulation. Neurology 61:S88\u2013S93","journal-title":"Neurology"},{"key":"5631_CR57","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.neuropharm.2004.01.008","volume":"46","author":"K Wirkner","year":"2004","unstructured":"Wirkner K, Gerevich Z, Krause T, G\u00fcnther A, K\u00f6les L, Schneider D, N\u00f6renberg W, Illes P (2004) Adenosine A2A receptor-induced inhibition of NMDA and GABAA receptor-mediated synaptic currents in a subpopulation of rat striatal neurons. Neuropharmacology 46:994\u20131007","journal-title":"Neuropharmacology"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-020-05631-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00213-020-05631-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-020-05631-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T23:11:52Z","timestamp":1628377912000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00213-020-05631-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,8]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["5631"],"URL":"https:\/\/doi.org\/10.1007\/s00213-020-05631-8","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,8]]},"assertion":[{"value":"24 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures were approved by the East Tennessee State University Committee on Animal Care which is consistent with the National Institutes of Health Guide for the Animal Care.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}