{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:14:00Z","timestamp":1773382440618,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R56 DA036635"],"award-info":[{"award-number":["R56 DA036635"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2 TR000116-04"],"award-info":[{"award-number":["KL2 TR000116-04"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001998"],"award-info":[{"award-number":["UL1TR001998"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s00213-020-05702-w","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T23:02:36Z","timestamp":1604962956000},"page":"539-549","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Acute administration of oxycodone, alcohol, and their combination on simulated driving\u2014preliminary outcomes in healthy adults"],"prefix":"10.1007","volume":"238","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1450-2621","authenticated-orcid":false,"given":"Shanna","family":"Babalonis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion A.","family":"Coe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Nuzzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle R.","family":"Lofwall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Sloan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura C.","family":"Fanucchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon L.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,9]]},"reference":[{"key":"5702_CR1","unstructured":"American Pain Society. Pain management and dosing guide. 2016. http:\/\/americanpainsociety.org\/uploads\/education\/PAMI_Pain_Mangement_and_Dosing_Guide_02282017.pdf"},{"issue":"1-2","key":"5702_CR2","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.drugalcdep.2012.09.018","volume":"129","author":"S Babalonis","year":"2013","unstructured":"Babalonis S, Lofwall MR, Nuzzo PA, Siegel AJ, Walsh SL (2013) Abuse liability and reinforcing efficacy of oral tramadol in humans. Drug Alcohol Depend 129(1-2):116\u2013124","journal-title":"Drug Alcohol Depend"},{"issue":"12","key":"5702_CR3","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1002\/jcph.557","volume":"55","author":"S Babalonis","year":"2015","unstructured":"Babalonis S, Hampson AJ, Lofwall MR, Nuzzo PA, Walsh SL (2015) Quinine as a potential tracer for medication adherence: a pharmacokinetic and pharmacodynamic assessment of quinine alone and in combination with oxycodone in humans. J Clin Pharmacol 55(12):1332\u20131343","journal-title":"J Clin Pharmacol"},{"key":"5702_CR4","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1016\/j.sbspro.2012.06.1259","volume":"48","author":"IM Bernhoft","year":"2012","unstructured":"Bernhoft IM, Hels T, Lyckegaard A, Houwing S, Verstraete AG (2012) Prevalence and risk of injury in Europe by driving with alcohol, illicit drugs and medicines. Procedia Soc Behav Sci 48:2907\u20132916","journal-title":"Procedia Soc Behav Sci"},{"key":"5702_CR5","volume-title":"Results of the 2013\u20132014 National Roadside Survey of alcohol and drug use by drivers. Traffic Safety Facts Research Note. Report No. DOT HS 812 118","author":"A Berning","year":"2015","unstructured":"Berning A, Compton R, Wochinger K (2015) Results of the 2013\u20132014 National Roadside Survey of alcohol and drug use by drivers. Traffic Safety Facts Research Note. Report No. DOT HS 812 118. National Highway Traffic Safety Administration, Washington, DC"},{"key":"5702_CR6","doi-asserted-by":"publisher","first-page":"S97","DOI":"10.1080\/15389588.2017.1378814","volume":"19","author":"TL Brown","year":"2018","unstructured":"Brown TL, Milavetz G, Gaffney G, Spurgin A (2018) Evaluating drugged driving: effects of exemplar pain and anxiety medications. Traffic Inj Prev 19:S97\u2013S103","journal-title":"Traffic Inj Prev"},{"key":"5702_CR7","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.aap.2017.10.004","volume":"109","author":"S Chihuri","year":"2017","unstructured":"Chihuri S, Li G (2017a) Use of prescription opioids and motor vehicle crashes: a meta analysis. Accid Anal Prev 109:123\u2013131","journal-title":"Accid Anal Prev"},{"key":"5702_CR8","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.2105\/AJPH.2017.303902","volume":"107","author":"S Chihuri","year":"2017","unstructured":"Chihuri S, Li G (2017b) Trends in prescription opioids detected in fatally injured drivers in 6 US states: 1995-2015. Am J Public Health 107:1487\u20131492","journal-title":"Am J Public Health"},{"key":"5702_CR9","doi-asserted-by":"publisher","first-page":"e188081","DOI":"10.1001\/jamanetworkopen.2018.8081","volume":"2","author":"S Chihuri","year":"2019","unstructured":"Chihuri S, Li G (2019) Use of prescription opioids and initiation of fatal 2-vehicle crashes. JAMA Netw Open 2:e188081","journal-title":"JAMA Netw Open"},{"key":"5702_CR10","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.amepre.2019.02.025","volume":"57","author":"MB Esser","year":"2019","unstructured":"Esser MB, Guy GP Jr, Zhang K, Brewer RD (2019) Binge drinking and prescription opioid misuse in the US, 2012\u20132014. Am J Prev Med 57:197\u2013208","journal-title":"Am J Prev Med"},{"key":"5702_CR11","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1177\/0269216317746583","volume":"32","author":"DH Ferreira","year":"2018","unstructured":"Ferreira DH, Boland JW, Phillips JL, Lam L, Currow DC (2018) The impact of therapeutic opioid agonists on driving-related psychomotor skills assessed by a driving simulator or an on-road driving task: a systematic review. Palliat Med 32:786\u2013803","journal-title":"Palliat Med"},{"key":"5702_CR12","first-page":"371","volume":"133","author":"HF Fraser","year":"1961","unstructured":"Fraser HF, Van Horn GD, Martin WR, Wolbach AB, Isbell H (1961) Methods for evaluating addiction liability. (A) \u201cAttitude\u201d of opiate addicts toward opiate-like drugs. (B) A short-term \u201cdirect\u201d addiction test. J Pharmacol Exp Ther 133:371\u2013387","journal-title":"J Pharmacol Exp Ther"},{"key":"5702_CR13","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0885-3924(99)00158-X","volume":"19","author":"T Galski","year":"2000","unstructured":"Galski T, Williams JB, Ehle HT (2000) Effects of opioids on driving ability. J Pain Symptom Manage 19:200\u2013208","journal-title":"J Pain Symptom Manage"},{"key":"5702_CR14","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1097\/JCP.0000000000001101","volume":"39","author":"AC Hayley","year":"2019","unstructured":"Hayley AC, Downey LA, Green M, Shiferaw B, Kenneally M, Keane M, Adams M, Shehabi Y (2019) Driving simulator performance after administration of analgesic doses of ketamine with dexmedetomidine or fentanyl. J Clin Psychopharmacol 39:446\u2013454","journal-title":"J Clin Psychopharmacol"},{"key":"5702_CR15","volume-title":"Drug-impaired driving: marijuana and opioids raise critical issues for states","author":"J Hedlund","year":"2018","unstructured":"Hedlund J, Macek K (2018) Drug-impaired driving: marijuana and opioids raise critical issues for states. Governor\u2019s Highway Safety Association, Washington, DC https:\/\/www.ghsa.org\/resources\/DUID18"},{"key":"5702_CR16","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.aap.2017.03.001","volume":"102","author":"C Irwin","year":"2017","unstructured":"Irwin C, Iudakhina E, Desbrow B, McCartney D (2017) Effects of acute alcohol consumption on measures of simulated driving: a systematic review and meta-analysis. Accid Anal Prev 102:248\u2013266","journal-title":"Accid Anal Prev"},{"key":"5702_CR17","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.aap.2016.01.001","volume":"89","author":"S Jongen","year":"2016","unstructured":"Jongen S, Vuurman EF, Ramaekers JG, Vermeeren A (2016) The sensitivity of laboratory tests assessing driving related skills to dose-related impairment of alcohol: a literature review. Accid Anal Prev 89:31\u201348","journal-title":"Accid Anal Prev"},{"key":"5702_CR18","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1001\/archgenpsychiatry.2011.26","volume":"68","author":"AC King","year":"2011","unstructured":"King AC, de Wit H, McNamara PJ, Cao D (2011) Rewarding, stimulant, and sedative alcohol responses and relationship to future binge drinking. Arch Gen Psychiatry 68:389\u2013399","journal-title":"Arch Gen Psychiatry"},{"key":"5702_CR19","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.biopsych.2013.08.001","volume":"75","author":"AC King","year":"2014","unstructured":"King AC, McNamara PJ, Hasin DS, Cao D (2014) Alcohol challenge responses predict future alcohol use disorder symptoms: a 6-year prospective study. Biol Psychiatry 75:798\u2013806","journal-title":"Biol Psychiatry"},{"issue":"e38","key":"5702_CR20","first-page":"1","volume":"5","author":"AC King","year":"2019","unstructured":"King AC, Cao D, de Wit H, O\u2019Connor SJ, Hasin DS (2019) The role of alcohol response phenotypes in the risk for alcohol use disorder. Br J Psych 5(e38):1\u20133","journal-title":"Br J Psych"},{"key":"5702_CR21","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s00213-013-3147-0","volume":"230","author":"MG Kirkpatrick","year":"2013","unstructured":"Kirkpatrick MG, de Wit H (2013) In the company of others: social factors alter acute alcohol effects. Psychopharmacology (Berl) 230:215\u2013226","journal-title":"Psychopharmacology (Berl)"},{"key":"5702_CR22","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.ejpain.2004.05.010","volume":"9","author":"HG Kress","year":"2005","unstructured":"Kress HG, Kraft B (2005) Opioid medication and driving ability. Eur J Pain 9:141\u2013144","journal-title":"Eur J Pain"},{"key":"5702_CR23","volume-title":"Drug and alcohol crash risk: a case-control study (Report No. DOT HS 812 355)","author":"JH Lacey","year":"2016","unstructured":"Lacey JH, Kelley-Baker T, Berning A, Romano E, Ramirez A, Yao J, Moore C, Brainard K, Carr K, Pell K, Compton R (2016) Drug and alcohol crash risk: a case-control study (Report No. DOT HS 812 355). National Highway Traffic Safety Administration, Washington, DC"},{"key":"5702_CR24","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.drugalcdep.2003.08.002","volume":"72","author":"MG Lenne","year":"2003","unstructured":"Lenne MG, Dietze P, Rumbold GR, Redman JR, Triggs TJ (2003) The effects of the opioid pharmacotherapies methadone, LAAM and buprenorphine, alone and in combination with alcohol, on simulated driving. Drug Alcohol Depend 72:271\u2013278","journal-title":"Drug Alcohol Depend"},{"key":"5702_CR25","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1002\/cpt1974154368","volume":"15","author":"M Linnoila","year":"1974","unstructured":"Linnoila M, Hakkinen S (1974) Effects of diazepam and codeine, alone and in combination with alcohol, on simulated driving. Clin Pharmacol Ther 15:368\u2013373","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"5702_CR26","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/j.1530-0277.1993.tb00739.x","volume":"17","author":"CS Martin","year":"1993","unstructured":"Martin CS, Earleywine M, Musty RE, Perrine MW, Swift RM (1993) Development and validation of the biphasic alcohol effects scale. Alcohol Clin Exp Res 17(1):140\u2013146","journal-title":"Alcohol Clin Exp Res"},{"key":"5702_CR27","doi-asserted-by":"publisher","first-page":"817","DOI":"10.2147\/DDDT.S77978","volume":"9","author":"L Miceli","year":"2015","unstructured":"Miceli L, Bednarova R, Rizzardo A, Samogin V, Della Rocca G (2015) Development of a test for recording both visual and auditory reaction times, potentially useful for future studies in patients on opioids therapy. Drug Des Devel Ther 9:817","journal-title":"Drug Des Devel Ther"},{"key":"5702_CR28","volume-title":"Alcohol-impaired driving: 2018 data (Traffic Safety Facts. Report No. DOT HS 812 864)","author":"National Center for Statistics and Analysis","year":"2019","unstructured":"National Center for Statistics and Analysis (2019) Alcohol-impaired driving: 2018 data (Traffic Safety Facts. Report No. DOT HS 812 864). National Highway Traffic Safety Administration, Washington, DC"},{"key":"5702_CR29","unstructured":"National Survey on Drug Use and Health, Center for Behavioral Health Statistics and Quality. Results from the 2018 National Survey on Drug Use and Health: detailed tables. Rockville (MD): SAMHSA; 2019. https:\/\/www.samhsa.gov\/data\/report\/2018-nsduh-detailed-tables"},{"key":"5702_CR30","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.ejpain.2010.09.008","volume":"15","author":"HK Nilsen","year":"2011","unstructured":"Nilsen HK, Landro NI, Kaasa S, Jenssen GD, Fayers P, Borchgrevink PC (2011) Driving functions in a video simulator in chronic non-malignant pain patients using and not using codeine. Eur J Pain 15:409\u2013415","journal-title":"Eur J Pain"},{"key":"5702_CR31","first-page":"9","volume":"25","author":"CR Rush","year":"2001","unstructured":"Rush CR (2001) Pretreatment with hydromorphone, a mu-opioid agonist, does not alter the acute behavioral and physiological effects of ethanol in humans. Alcohol Clin Exp Res 25:9\u201317","journal-title":"Alcohol Clin Exp Res"},{"key":"5702_CR32","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/hup.2394","volume":"29","author":"B Setnik","year":"2014","unstructured":"Setnik B, Sokolowska M, Johnson F, Oldenhof J, Romach M (2014) Evaluation of the safety, pharmacodynamic, and pharmacokinetic effects following oral coadministration of immediate-release morphine with ethanol in healthy male participants. Hum Psychopharmacol 29:251\u2013265","journal-title":"Hum Psychopharmacol"},{"key":"5702_CR33","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1080\/15389588.2017.1326595","volume":"18","author":"MC Strand","year":"2017","unstructured":"Strand MC, Arnestad M, Fjeld B, Morland J (2017) Acute impairing effects of morphine related to driving: a systematic review of experimental studies to define blood morphine concentrations related to impairment in opioid-naive subjects. Traffic Inj Prev 18:788\u2013794","journal-title":"Traffic Inj Prev"},{"key":"5702_CR34","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1111\/bcp.13818","volume":"85","author":"MC Strand","year":"2019","unstructured":"Strand MC, Vindenes V, Gjerde H, Morland JG, Ramaekers JG (2019) A clinical trial on the acute effects of methadone and buprenorphine on actual driving and cognitive function of healthy volunteers. Br J Clin Pharmacol 85:442\u2013453","journal-title":"Br J Clin Pharmacol"},{"key":"5702_CR35","doi-asserted-by":"publisher","first-page":"e202361","DOI":"10.1001\/jamanetworkopen.2020.2361","volume":"3","author":"ME Tori","year":"2020","unstructured":"Tori ME, Larochelle MR, Naimi TS (2020) Alcohol or benzodiazepine co-involvement with opioid overdose deaths in the United States, 1999-2017. JAMA Netw Open 3:e202361","journal-title":"JAMA Netw Open"},{"key":"5702_CR36","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.drugalcdep.2008.05.007","volume":"98","author":"SL Walsh","year":"2008","unstructured":"Walsh SL, Nuzzo PA, Lofwall MR, Holtman JR Jr (2008) The relative abuse liability of oral oxycodone, hydrocodone and hydromorphone assessed in prescription opioid abusers. Drug Alcohol Depend 98:191\u2013202","journal-title":"Drug Alcohol Depend"},{"key":"5702_CR37","doi-asserted-by":"publisher","first-page":"107630","DOI":"10.1016\/j.drugalcdep.2019.107630","volume":"205","author":"AK Yadav","year":"2019","unstructured":"Yadav AK, Velaga NR (2019) Laboratory analysis of driving behavior and self-perceived physiological impairment at 0.03%, 0.05% and 0.08% blood alcohol concentrations. Drug Alcohol Depend 205:107630","journal-title":"Drug Alcohol Depend"},{"key":"5702_CR38","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s00213-011-2349-6","volume":"218","author":"JP Zacny","year":"2011","unstructured":"Zacny JP, Gutierrez S (2011) Subjective, psychomotor, and physiological effects of oxycodone alone and in combination with ethanol in healthy volunteers. Psychopharmacology (Berl) 218:471\u2013481","journal-title":"Psychopharmacology (Berl)"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-020-05702-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-020-05702-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-020-05702-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T10:25:44Z","timestamp":1611397544000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-020-05702-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,9]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["5702"],"URL":"https:\/\/doi.org\/10.1007\/s00213-020-05702-w","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"value":"0033-3158","type":"print"},{"value":"1432-2072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,9]]},"assertion":[{"value":"26 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All participants provided sober, written informed consent prior to participation and were paid for their participation. The study was approved by the University of Kentucky Institutional Review Board and was conducted in accordance with the Helsinki guidelines for ethical research.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}