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The approaches several recent publications on the topic have taken to analyze such mechanisms have some pitfalls and limitations. Based on the rich literature on mechanisms and mediation analysis in psychological science, I comment on five particular issues: (1) Separating mediating and moderating factors, (2) problems inherent in using cross-sectional data, (3) statistical methods in mediation analysis, (4) assumptions and limitations inherent in traditional mediation analysis, and (5) criteria beyond mediation to establish a mechanism. Suggested practices for future research on the psychological mechanisms through which drugs have their effects are presented.<\/jats:p>","DOI":"10.1007\/s00213-020-05703-9","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T05:03:09Z","timestamp":1604552589000},"page":"3799-3802","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Uncovering psychological mechanisms mediating the effects of drugs: some issues and comments using the example of psychedelic drugs"],"prefix":"10.1007","volume":"237","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0480-9806","authenticated-orcid":false,"given":"Samuli","family":"Kangaslampi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"issue":"4","key":"5703_CR1","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1037\/a0018933","volume":"98","author":"JG Bullock","year":"2010","unstructured":"Bullock JG, Green DP, Ha SE (2010) Yes, but what\u2019s the mechanism? 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