{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T16:29:40Z","timestamp":1742401780752,"version":"3.37.3"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/1577"],"award-info":[{"award-number":["PI19\/1577"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Psychopharmacology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s00213-020-05704-8","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T07:03:45Z","timestamp":1610003025000},"page":"551-557","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic deletion of dopamine D1 receptors increases the sensitivity to cannabinoid CB1 receptor antagonist-precipitated withdrawal when compared with wild-type littermates: studies in female mice repeatedly exposed to the Spice cannabinoid HU-210"],"prefix":"10.1007","volume":"238","author":[{"given":"Antonia","family":"Serrano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Vadas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belen","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ainhoa","family":"Bilbao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelia","family":"Granado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Javier","family":"Pavon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosario","family":"Moratalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4516-5795","authenticated-orcid":false,"given":"Fernando","family":"Rodr\u00edguez de Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"5704_CR1","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1056\/NEJMoa1610300","volume":"376","author":"AJ Adams","year":"2017","unstructured":"Adams AJ, Banister SD, Irizarry L, Trecki J, Schwartz M, Gerona R (2017) \"zombie\" outbreak caused by the synthetic cannabinoid AMB-FUBINACA in New York. N Engl J Med 376:235\u2013242","journal-title":"N Engl J Med"},{"key":"5704_CR2","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/S0301-0082(98)00087-2","volume":"58","author":"A Ameri","year":"1999","unstructured":"Ameri A (1999) The effects of cannabinoids on the brain. Prog Neurobiol 58:315\u2013348","journal-title":"Prog Neurobiol"},{"key":"5704_CR3","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1097\/01.yco.0000218592.00689.e5","volume":"19","author":"AJ Budney","year":"2006","unstructured":"Budney AJ, Hughes JR (2006) The cannabis withdrawal syndrome. Curr Opin Psychiatry 19:233\u2013238","journal-title":"Curr Opin Psychiatry"},{"key":"5704_CR4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.drugalcdep.2014.08.005","volume":"144","author":"MS Castaneto","year":"2014","unstructured":"Castaneto MS, Gorelick DA, Desrosiers NA, Hartman RL, Pirard S, Huestis MA (2014) Synthetic cannabinoids: epidemiology, pharmacodynamics, and clinical implications. Drug Alcohol Depend 144:12\u201341","journal-title":"Drug Alcohol Depend"},{"key":"5704_CR5","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/S0028-3908(03)00113-8","volume":"44","author":"F Chaperon","year":"2003","unstructured":"Chaperon F, Tricklebank MD, Unger L, Neijt HC (2003) Evidence for regulation of body temperature in rats by dopamine D2 receptor and possible influence of D1 but not D3 and D4 receptors. Neuropharmacology 44:1047\u20131053","journal-title":"Neuropharmacology"},{"key":"5704_CR6","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/j.1476-5381.1978.tb08466.x","volume":"62","author":"B Cox","year":"1978","unstructured":"Cox B, Lee TF (1978) Is acetylcholine involved in a dopamine receptor mediated hypothermia in mice and rats? Br J Pharmacol 62:339\u2013347","journal-title":"Br J Pharmacol"},{"key":"5704_CR7","volume-title":"Health and social responses to drug problems: a European guide","author":"EMCDDA","year":"2017","unstructured":"EMCDDA (2017) Health and social responses to drug problems: a European guide. Publications Office of the EU, Luxembourg"},{"key":"5704_CR8","unstructured":"EMCDDA (2020) https:\/\/www.emcdda.europa.eu\/publications\/drug-profiles\/synthetic-cannabinoids_en"},{"key":"5704_CR9","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.brainresbull.2005.08.023","volume":"68","author":"ED Festa","year":"2006","unstructured":"Festa ED, Jenab S, Weiner J, Nazarian A, Niyomchai T, Russo SJ, Kemen LM, Akhavan A, Wu HB, Quinones-Jenab V (2006) Cocaine-induced sex differences in D1 receptor activation and binding levels after acute cocaine administration. Brain Res Bull 68:277\u2013284","journal-title":"Brain Res Bull"},{"key":"5704_CR10","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0014-2999(97)01442-8","volume":"341","author":"GL Gessa","year":"1998","unstructured":"Gessa GL, Melis M, Muntoni AL, Diana M (1998) Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors. Eur J Pharmacol 341:39\u201344","journal-title":"Eur J Pharmacol"},{"key":"5704_CR11","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1038\/sj.bjp.0702228","volume":"125","author":"DM Hutcheson","year":"1998","unstructured":"Hutcheson DM, Tzavara ET, Smadja C, Valjent E, Roques BP, Hanoune J, Maldonado R (1998) Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9-tetrahydrocannabinol. Br J Pharmacol 125:1567\u20131577","journal-title":"Br J Pharmacol"},{"key":"5704_CR12","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0306-4522(03)00070-8","volume":"119","author":"MD Julian","year":"2003","unstructured":"Julian MD, Martin AB, Cuellar B, Rodriguez De Fonseca F, Navarro M, Moratalla R, Garcia- Segura LM (2003) Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal ganglia. Neuroscience 119:309\u2013318","journal-title":"Neuroscience"},{"key":"5704_CR13","doi-asserted-by":"publisher","first-page":"10516","DOI":"10.1038\/s41598-017-10447-2","volume":"7","author":"O Malyshevskaya","year":"2017","unstructured":"Malyshevskaya O, Aritake K, Kaushik MK, Uchiyama N, Cherasse Y, Kikura-Hanajiri R, Urade Y (2017) Natural ((9)-THC) and synthetic (JWH-018) cannabinoids induce seizures by acting through the cannabinoid CB1 receptor. Sci Rep 7:10516","journal-title":"Sci Rep"},{"key":"5704_CR14","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1038\/sj.npp.1301558","volume":"33","author":"AB Martin","year":"2008","unstructured":"Martin AB, Fernandez-Espejo E, Ferrer B, Gorriti MA, Bilbao A, Navarro M, Rodriguez de Fonseca F, Moratalla R (2008) Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors. Neuropsychopharmacology 33:1667\u20131679","journal-title":"Neuropsychopharmacology"},{"key":"5704_CR15","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0014-2999(97)01560-4","volume":"344","author":"JL Mart\u00edn-Calder\u00f3n","year":"1998","unstructured":"Mart\u00edn-Calder\u00f3n JL, Mu\u00f1oz RM, Villan\u00faa MA, del Arco I, Moreno JL, de Fonseca FR, Navarro M (1998) Characterization of the acute endocrine actions of (\u2212)-11-hydroxy-delta8-tetrahydrocannabinol-dimethylheptyl (HU-210), a potent synthetic cannabinoid in rats. Eur J Pharmacol 344:77\u201386","journal-title":"Eur J Pharmacol"},{"key":"5704_CR16","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1037\/pha0000027","volume":"23","author":"JA Marusich","year":"2015","unstructured":"Marusich JA, Craft RM, Lefever TW, Wiley JL (2015) The impact of gonadal hormones on cannabinoid dependence. Exp Clin Psychopharmacol 23:206\u2013216","journal-title":"Exp Clin Psychopharmacol"},{"key":"5704_CR17","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0091-3057(00)00231-8","volume":"66","author":"F Nava","year":"2000","unstructured":"Nava F, Carta G, Gessa GL (2000) Permissive role of dopamine D(2) receptors in the hypothermia induced by delta(9)-tetrahydrocannabinol in rats. Pharmacol Biochem Behav 66:183\u2013187","journal-title":"Pharmacol Biochem Behav"},{"key":"5704_CR18","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1527-3458.2001.tb00192.x","volume":"7","author":"A Ottani","year":"2001","unstructured":"Ottani A, Giuliani D (2001) Hu 210: a potent tool for investigations of the cannabinoid system. CNS Drug Rev 7:131\u2013145","journal-title":"CNS Drug Rev"},{"key":"5704_CR19","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0028-3908(94)00133-D","volume":"34","author":"H Ovadia","year":"1995","unstructured":"Ovadia H, Wohlman A, Mechoulam R, Weidenfeld J (1995) Characterization of the hypothermic effect of the synthetic cannabinoid HU-210 in the rat. Relation to the adrenergic system and endogenous pyrogens. Neuropharmacology 34:175\u2013180","journal-title":"Neuropharmacology"},{"key":"5704_CR20","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/0014-5793(94)00773-X","volume":"350","author":"M Rinaldi-Carmona","year":"1994","unstructured":"Rinaldi-Carmona M, Barth F, Heaulme M, Shire D, Calandra B, Congy C, Martinez S, Maruani J, Neliat G, Caput D et al (1994) SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 350:240\u2013244","journal-title":"FEBS Lett"},{"key":"5704_CR21","first-page":"56","volume":"276","author":"F Rodriguez de Fonseca","year":"1996","unstructured":"Rodriguez de Fonseca F, Rubio P, Menzaghi F, Merlo-Pich E, Rivier J, Koob GF, Navarro M (1996) Corticotropin-releasing factor (CRF) antagonist [D-Phe12,Nle21,38,C alpha MeLeu37]CRF attenuates the acute actions of the highly potent cannabinoid receptor agonist HU-210 on defensive-withdrawal behavior in rats. J Pharmacol Exp Ther 276:56\u201364","journal-title":"J Pharmacol Exp Ther"},{"key":"5704_CR22","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1126\/science.276.5321.2050","volume":"276","author":"F Rodr\u00edguez de Fonseca","year":"1997","unstructured":"Rodr\u00edguez de Fonseca F, Carrera MR, Navarro M, Koob GF, Weiss F (1997) Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal. Science. 276:2050\u20132054","journal-title":"Science."},{"key":"5704_CR23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/BF03033228","volume":"3","author":"F Rodriguez De Fonseca","year":"2001","unstructured":"Rodriguez De Fonseca F, Gorriti MA, Bilbao A, Escuredo L, Garcia-Segura LM, Piomelli D, Navarro M (2001) Role of the endogenous cannabinoid system as a modulator of dopamine transmission: implications for Parkinson's disease and schizophrenia. Neurotox Res 3:23\u201335","journal-title":"Neurotox Res"},{"key":"5704_CR24","first-page":"813","volume":"285","author":"T Rubino","year":"1998","unstructured":"Rubino T, Patrini G, Massi P, Fuzio D, Vigano D, Giagnoni G, Parolaro D (1998) Cannabinoid- precipitated withdrawal: a time-course study of the behavioral aspect and its correlation with cannabinoid receptors and G protein expression. J Pharmacol Exp Ther 285:813\u2013819","journal-title":"J Pharmacol Exp Ther"},{"key":"5704_CR25","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1111\/j.1460-9568.2004.03682.x","volume":"20","author":"G Soria","year":"2004","unstructured":"Soria G, Castane A, Berrendero F, Ledent C, Parmentier M, Maldonado R, Valverde O (2004) Adenosine A2A receptors are involved in physical dependence and place conditioning induced by THC. Eur J Neurosci 20:2203\u20132213","journal-title":"Eur J Neurosci"},{"key":"5704_CR26","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.ejphar.2003.08.101","volume":"480","author":"M van der Stelt","year":"2003","unstructured":"van der Stelt M, Di Marzo V (2003) The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders. Eur J Pharmacol 480:133\u2013150","journal-title":"Eur J Pharmacol"},{"key":"5704_CR27","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.drugalcdep.2018.05.029","volume":"191","author":"KR Trexler","year":"2018","unstructured":"Trexler KR, Nass SR, Crowe MS, Gross JD, Jones MS, McKitrick AW, Siderovski DP, Kinsey SG (2018) Novel behavioral assays of spontaneous and precipitated THC withdrawal in mice. Drug Alcohol Depend 191:14\u201324","journal-title":"Drug Alcohol Depend"},{"key":"5704_CR28","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.pbb.2014.06.007","volume":"124","author":"AA Wakley","year":"2014","unstructured":"Wakley AA, McBride AA, Vaughn LK, Craft RM (2014) Cyclic ovarian hormone modulation of supraspinal Delta9-tetrahydrocannabinol-induced antinociception and cannabinoid receptor binding in the female rat. Pharmacol Biochem Behav 124:269\u2013277","journal-title":"Pharmacol Biochem Behav"},{"key":"5704_CR29","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/0092-8674(94)90557-6","volume":"79","author":"M Xu","year":"1994","unstructured":"Xu M, Moratalla R, Gold LH, Hiroi N, Koob GF, Graybiel AM, Tonegawa S (1994) Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell 79:729\u2013742","journal-title":"Cell"},{"key":"5704_CR30","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.neuroscience.2016.06.043","volume":"332","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Guo J, Guo A, Li Y (2016) Nicotine-induced acute hyperactivity is mediated by dopaminergic system in a sexually dimorphic manner. Neuroscience 332:149\u2013159","journal-title":"Neuroscience"}],"container-title":["Psychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-020-05704-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00213-020-05704-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00213-020-05704-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T10:27:03Z","timestamp":1611397623000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00213-020-05704-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,7]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["5704"],"URL":"https:\/\/doi.org\/10.1007\/s00213-020-05704-8","relation":{},"ISSN":["0033-3158","1432-2072"],"issn-type":[{"type":"print","value":"0033-3158"},{"type":"electronic","value":"1432-2072"}],"subject":[],"published":{"date-parts":[[2021,1,7]]},"assertion":[{"value":"12 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}