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All procedures performed in studies involving animals (mice) were in accordance with the ethical standards of the Central Animal Facility at the University of Buenos Aires (animal protocol #50-2015, and #67-2015). Principles of mice care of the Central Animal Facility (University of Buenos Aires) were in accordance with the National Institutes of Health guide (NIH Publications, No. 8023, revised 1978) for the care and use of Laboratory animals, ARRIVE guidelines and CONICET (2003), and approved by its authorities using OLAW\/ARENA directives (NIH, Bethesda, MD, USA). The experiments in this study complied with the current laws of Argentina. 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